CLUSTAL W (1.83) multiple sequence alignment IRAKg_e-1_Smoe MAFCN-VA-------LFILILPV---AVLASE-------IEKGSSIQ-TGESLKADEILI IRAKg_d-2_Smoe MFLMF-LA-------FRILLFCCLCYIILTSVAADG---GSPGTTIIVRGEDP--QTWIT IRAKg_r-1_Smoe MK------L-----LTLMLLLSS---IYYSRVL-AD---FLRGSTVTT-G-----S-PWR IRAKg_d-1_Smoe MLLMF-LA-------FRILLFCCLCYVILTSVAADG---GSPGTTIIVRGEDP--QTWIT IRAKg_f_Smoe MPLLL-LF-------LAAALV-V-----LAN-GKSS---LQVGDVLAV-N-----Q-FLV IRAKg_e-2_Smoe ------------------------------------------------------------ IRAKg_o_Smoe MSETTFMKL-----LTLMLLLSS---TYYSRVL-AD---FLRGSTVTT-G-----S-PWR IRAKg_v_Smoe MVAVS-SFF-------FGVLT----CSIGAAEAQQQARKHGPGSN------------STQ IRAKg_s_Smoe ------------------------------------------------------------ IRAKg_q_Smoe ------------------------------------------------------------ IRAKg_a-1_Smoe MVDAL-LSS-------AIAILW-ISCSLPSSLAQDQ---FASGQTIAT-A-----GAAAS IRAKg_a-2_Smoe MVDAL-LSS-------AIAILW-ISSSLPSSLAQDQ---FASGQTIAT-A-----GAATS IRAKg_g_Smoe M----------------------------------------------------------- IRAKg_u-2_Smoe MAAKL-VT-------LVLLVL-L---V-LNC---EG---IGLGDKLGA-R-----QPPWM IRAKg_p_Smoe MSETTFMKL-----HTLMLLLSS---TYYSRVL-AD---FLRGSTVTT-G-----S-PWR IRAKg_b_Smoe MLSMF-LA-------FRILLLCCLCYVILTSVATDG---GSPGTTINVRGEDP--QTWIT IRAKg_n-2_Smoe MFLY-----------FRILMLC---SFILTFVAADG---GSPGTTTIVRGEDL--QPWIT IRAKg_k-1_Smoe MASQI-VVMVTAKIMALLQFLF-LS-LLPLALAYDR---MPLGSSLLT-T-----ES-LI IRAKg_n-1_Smoe M----------------------------------------------------------- IRAKg_h_Smoe MLSMF-LA-------FRILLLCCLCYVILTSVATDG---GSPGTTINVRGEDP--QTWIT IRAKg_k-2_Smoe MASQI-VVMVTAKIMALLQFLF-LS-LLPLALAYDR---MPLGSSLLT-T-----ES-LI IRAKg_r-2_Smoe MK------L-----LTLMLLLSS---IYYSRVL-AD---FLRGSTVTT-G-----S-PWR IRAKg_m-1_Smoe MAL-----------AFLLLVAFA---IACS--A-ME---IEIGSSLKL-G-----S-QWN IRAKg_u-1_Smoe MAAKL-VT-------LVLLVL-L---V-LNC---KG---IGLGDKLGA-G-----QPPWM IRAKg_c_Smoe MPLLL-LF-------LASALV-V-----LAN-GKSS---LQVGDVLAV-N-----Q-FLV IRAKg_o-1_Smoe MAKAL-SL-------VLIATLSS---V-LSS---RA---VQLGEKLSA-G-----NPPWI IRAKg_m-2_Smoe MAL-----------AFLLLVAFA---IACS--A-ME---IEIGSSLKL-G-----S-QWN IRAKg_o-2_Smoe MAKAL-SL-------VLIATLSS---V-LSS---RA---VQLGEKLSA-G-----NPPWI IRAKg_e-1_Smoe SPGKNFGFGFVNDTG-APGKLNVAIRVR-SV-ET----IIWTA-TAL------------K IRAKg_d-2_Smoe SPNATFSAGFSHINH-TFPLYSFSIWYTKMP-NT----VVWSA-MSN---DT---GGFPI IRAKg_r-1_Smoe SPGGTFGFGFVMST----RNFNLAIWYDIDPKKT----VIWMA-MAN---------GQLI IRAKg_d-1_Smoe SPNATFSAGFGHLNP-TSPLYSFSIWYTKMP-NT----VVWSA-MSN---DT---GGFPI IRAKg_f_Smoe SPDNTFELGFVDDE--ASGKFTLVIRFHHINLKT----IVWTA-PAA----------PSV IRAKg_e-2_Smoe ------------------------------------------------------------ IRAKg_o_Smoe SPEGTFGFGFVMPESSRTRNFNLAIWYDIDPKKT----VVWMA-MAN---------GQLV IRAKg_v_Smoe VPNG-------------------------------------DKDGLP------------A IRAKg_s_Smoe ------------------------------------------------------------ IRAKg_q_Smoe ------------------------------------------------------------ IRAKg_a-1_Smoe ISSGSFSLGFAPSP-RSPGEFELGIWYRADSQQV----LVWDT-AA-------------P IRAKg_a-2_Smoe VSSGSFSLGFAPSP-RSPGEFELGIWYRADPQQV----LVWDT-AA-------------P IRAKg_g_Smoe ------------------------------------------------------------ IRAKg_u-2_Smoe SLNNTFAFGFHTSDG-IGELFTLAIWHQS-T-GT----VVWEA-TEALIKNGSTTEKPKI IRAKg_p_Smoe SPGGTFGFGFVMPETSSTRNFNLAIWYDIDPKKT----VVWMA-MAN---------GQLV IRAKg_b_Smoe SPNATFSTGFSHLNP-KSPLYSFSIWYTKMP-NT----VVWSA-MSN---DT---GGFPI IRAKg_n-2_Smoe SLKATFCAGFRHLDS-KSSLYSFSIWYTKMP-NT----VIWSA-MSN---DT---GGSPI IRAKg_k-1_Smoe SANGRVKLEFFSPTGGNSSDLYLGISFNTRTREFMEFIPIWIA-NRD------------T IRAKg_n-1_Smoe ------------------------------P-NT----VIWSA-MSN---DT---GGSPI IRAKg_h_Smoe SPNATFSTGFSHLNP-KSPLYSFSIWYTKMP-NT----VVWSA-MSN---DT---GGFPI IRAKg_k-2_Smoe SANGRVKLEFFSPTGGNSSDLYLGISFNTTTREIMEFIPIWIA-NRD------------T IRAKg_r-2_Smoe SPGGTFGLGFVMPESSSTRNFNLAIWYDIDPKKT----VIWMA-MAN---------GLLV IRAKg_m-1_Smoe SSGGTFSLGFHLMD----EAYNLAIWYQIDP-EE----IVWMA-TTD---N-----GQFV IRAKg_u-1_Smoe SLNSTFAFGFHTSDG-IGELFTLAIWHQR-T-GT----VVWEA-TEALIKNGSTTEKPKI IRAKg_c_Smoe SPDNTFELGFVDDE--ASGKFTLVIRFHHINLKT----IVWTA-PGA----------PSV IRAKg_o-1_Smoe SRGNTFAFGFYSTT---SGMSTLAIWYQS-T-GT----VVWEA-TLD---NGAST-KERV IRAKg_m-2_Smoe SSGGTFSLGFRLMD----EAYNLAIWYQIDP-EE----IVWMA-TTD---N-----GQFV IRAKg_o-2_Smoe SRGNTFAFGFYSTT---SGMSTLAIWYQS-T-GT----VVWEA-TLD---NGAST-KERV IRAKg_e-1_Smoe GVTANAQLVLNEAQGLFVLDNGVAQVIVSCK---SSNCSGVRLDMQDDGNLVLKHS---- IRAKg_d-2_Smoe GLIKGDQLVFQIDGRLVLTSNA-AGIIWGTS---TSTLGVIKALLQENGNLQLLTS---- IRAKg_r-1_Smoe QVSENAKLELKAEGGLSVTDGSSV-PLWQTN---PGQCCAESAALLENGNLVVLGK---- IRAKg_d-1_Smoe GLIKGDQLVFQTDGRLVLTSNA-AGIIWGTS---TSTLAVTKALLQENGNLQLLTS---- IRAKg_f_Smoe AFTANARLQLTAQG-LFVSDGAQ--LITI--AN---VPSVASAELQDNGNFVVISS---- IRAKg_e-2_Smoe --------------------------------------------MQDDGNLVLKHS---- IRAKg_o_Smoe QVSENAKLELKAEGGLSVTDGSSSAPLWQTN---PGQCCAESASLLENGNLVVLGK---- IRAKg_v_Smoe ASIAAGVLSLIVVGGLLL------------------------------------------ IRAKg_s_Smoe ------------------------------------------------------------ IRAKg_q_Smoe ------------------------------------------------------------ IRAKg_a-1_Smoe ASRAGAILQLSSDGSLAVRDGAS-TTSWT--SG-A--TGASSGQLQESGNLALRNS---- IRAKg_a-2_Smoe ASRPGAILELSSDGSLAVRDGAS-ITSWT--SG-A--TGASSGQLQESGNLALRNS---- IRAKg_g_Smoe ------------------------------------------------------------ IRAKg_u-2_Smoe KVGKTGELELKETG-LIVTDK--SMTVWLVR---CENCSIATASLEETGNFVLLDR---- IRAKg_p_Smoe QVSENAKLELKAKGGLSVTDGSSSVPFWQTN---PGQCCAESAALLENGNLVVLQK---- IRAKg_b_Smoe GLIKGDQLVFQTDGRLVLTSNA-AGIIWGTS---TSTLGVTKALLQENANLQLLTS---- IRAKg_n-2_Smoe GLIKCDQLAFQTDGRLILTSKA-AGIVWGTS---TTTLSVTKALLQENGNLELLAS---- IRAKg_k-1_Smoe PVTSNASLLLTSKGELQIIDRGS--IIWSGAPS-SSNSGITQAVLLDSGNFVLTDNSFDP IRAKg_n-1_Smoe GLIKGDQLAFQTDGRLILTSNA-AGIVWGTS---TTTLSVTKALLQENGNLELLAS---- IRAKg_h_Smoe GLIKGDQLVFQTDGRLVLTSNA-AGIIWGTS---TSTLGVTKALLQENGNLQLLTS---- IRAKg_k-2_Smoe PVTSNASLLLTSKGELQIIDRGS--IIWSGAPS-SSNSGITQAVLLDSGNFVLTDNAFDP IRAKg_r-2_Smoe QVSENAKLELKAEGGLSVTDGSSSVPLWQTN---PGQCCAESATLLENGNLVVLGK---- IRAKg_m-1_Smoe HASGSAQLQLRSDGGLVIIDRAS--ILWRTN---SGQ--AKGASLLETGNLVVYGE---- IRAKg_u-1_Smoe KVGKTGELELKETG-LIVTDK--SMTVWLVR---CENCSIATASLEETGNFVLLDR---- IRAKg_c_Smoe AFTANARLQLTAQG-LFVSDGAQ--LITI--AN---VPSVASAELQDNGNFVVISS---- IRAKg_o-1_Smoe SVSRNGVLELTATG-LVVTDA--SKPVWTSNLRCNNRCSVTVASLEENGNLVLLG----- IRAKg_m-2_Smoe HASGSAQLQLRSDGGLVIIDRAS--ILWRTN---SGQ--AKGASLLETGNLVVYGE---- IRAKg_o-2_Smoe SVSRNGVLELTATG-LVVTDA--SKPVWTSNLRCNNRCSVTVASLEENGNLVLLG----- IRAKg_e-1_Smoe ---NNSVLWQSFNLPTDTLLQDQVFK-------GRQALIS--GRYSLQMTDVSAQLIFLA IRAKg_d-2_Smoe ---NGVPVWQSFERPTDTLLPYQQLI-------GNTRLVSSNRKYDLRMDVSRVALYS-- IRAKg_r-1_Smoe ---DKKVAWQSFDSPTNNLLPEQQLRTQGNPSLGYMRLISQSGAYQLVLNSGQVLLKNL- IRAKg_d-1_Smoe ---NGVPVWQSFERPTDTLLPYQQLI-------GNTRLVSSNRKYDLRMDVSRVALYS-- IRAKg_f_Smoe ---SG--SWQSFDVPTDTLLTGQLIQ-------GNKDIL-RSGSFSLYLNQNSIGLKSY- IRAKg_e-2_Smoe ---NNSVLWQSFDLPTDTLLQDQVFK-------GRQALIS--GRYSLQMTDVSAQLIFLA IRAKg_o_Smoe ---DKKVAWQSFDSPTNNLLPEQQLRTQGNPSLGYTRLISQSGAYQLVLNSGQVLLKNL- IRAKg_v_Smoe ------------------------------------------------------------ IRAKg_s_Smoe ------------------------------------------------------------ IRAKg_q_Smoe ------------------------------------------------------------ IRAKg_a-1_Smoe ---SGQVVWSSFDHPSSTLLPGQFLPRGRNLT-------SRAGGYTLTMDQSGNLTLRW- IRAKg_a-2_Smoe ---SGQVVWSSFDHPSSTLLPGQFLSRGRNLT-------SRAGGYSLAMDQSGNLTLRW- IRAKg_g_Smoe ------------------------------------------------------------ IRAKg_u-2_Smoe ---SSDRIWQSFDFPTDTLLPGQELR-------GNTSLVA--GKYRLSMNRRGIELYF-- IRAKg_p_Smoe ---DKKVAWQSFDSPTNNLLPEQQLRTQGNPSLGYTRLISQSGAYQLVLNSGQVLLKNL- IRAKg_b_Smoe ---NGVPVWQSFDRPTDTILPDQQLI-------GNAQLVSNNRKYDLQMDGSRVALYS-- IRAKg_n-2_Smoe ---NGVPAWQSFDRPTDTILPDQQLI-------GITQLVSNNRKYFLQMDGSKVALYY-- IRAKg_k-1_Smoe RDDNAAYPWQSFDHPADAWVPRMKVSLRTNLTAWISKVSPARGRFVMTMRTSNEFVISP- IRAKg_n-1_Smoe ---NGVPAWQSFDRPTDTILPDQQLI-------GITQLVSNNRKYFLQMDGSKVAFYY-- IRAKg_h_Smoe ---NGVPVWQSFDRPTDTILPDQQLI-------GNAQLVSNNQKYDLQMDGSRVALYS-- IRAKg_k-2_Smoe RDDNATYPWQSFDHPADAWVPRMKMFLGANLTAWKSSVSPASGRFVMTMRTSNEFVIST- IRAKg_r-2_Smoe ---DKKVVWQSFDSPTDNLLPEQQLRTQGNPSLGYTRLISQSGAYQLVLNSGQVLLKNL- IRAKg_m-1_Smoe ---NEQFAWKSFDVPTTTILPEQQFHTET--VSDTKILFSQSRNYALQLNRGQVFLRNN- IRAKg_u-1_Smoe ---SSDRIWQSFDFPTDTLLPGQELR-------GNTSLVA--GKYRLSMNRRGIELYF-- IRAKg_c_Smoe ---SG--SWQSFDVPTDTLLTGQLIQ-------GNKDIL-RSGSFSLYLNQNSIGLKSY- IRAKg_o-1_Smoe ---NGTRLWQSFDSPTDTILPEQDLV-------GNMTLVS--GKYRLSMNKSSVGLYF-- IRAKg_m-2_Smoe ---NEQFAWKSFDVPTTTILPEQQFHTET--VSDTKILFSQSRNYALQLNRGQVFLRNN- IRAKg_o-2_Smoe ---NGTRLWQSFDSPTDTILPEQDLV-------GNMTLVS--GKYRLSMNKSSVGLYF-- IRAKg_e-1_Smoe APELKNLTSYWTIPQ-NLPSSSTGS-----------------NNSTSQSSRLVMNSSGIV IRAKg_d-2_Smoe -RG-YWLEPYWQIAN-DNCSSSA--------------------L---SPPRLNISTSGML IRAKg_r-1_Smoe --KLEIPQKYWSIAN-PTLNSTMTCLDDETGEHVLNNNACQPDRSLKFPAVMNLSSQGVL IRAKg_d-1_Smoe -QG-YWLEPYWKIAN-DNHSDSA--------------------V---SPPRLNFSTSGML IRAKg_f_Smoe AVPESNSQSYWDVQR-SPTSSNN-----------------------A--STLVMNSTGIL IRAKg_e-2_Smoe APELKNLTSYWTIPQ-NLPSSSTGS-----------------NNSTSQSSRLVMNSSGIV IRAKg_o_Smoe --KLEIPQKYWSIAN-PTLNSTMTCLDDETGEHVLNNNACQPDRSLKFPAVLNLS---VL IRAKg_v_Smoe ------------------------------------------------------------ IRAKg_s_Smoe ------------------------------------------------------------ IRAKg_q_Smoe ------------------------------------------------------------ IRAKg_a-1_Smoe -----RSAQYWSSDT-DGSGNSS-----------------------I-PTNAVVDVNGVL IRAKg_a-2_Smoe -----GSAQYWSSDT-DGNGNSS-----------------------I-PTNAVVDVNGVL IRAKg_g_Smoe ------------------------------------------------------------ IRAKg_u-2_Smoe -QDY-LNHSYWGIIN-KQLNTSE--------------------STMTSTPKFTFSIDGHL IRAKg_p_Smoe --KLEVPQKYWSIAN-PTLNSTMTCLDDETGE---------------------------- IRAKg_b_Smoe -QG-YWLEPYWTIKN-DNQSNSA--------------------V---SPPRLNFSTTGML IRAKg_n-2_Smoe -QG-YWLEPYWRIEN-ENQSNSA--------------------NS-VVSPRLNFSTSGML IRAKg_k-1_Smoe --TNDTSREYWTSGAWNGKIFSL-----------------------V-PQ-MTDNYLYTF IRAKg_n-1_Smoe -QG-YWLEPYWRIEN-ENQSNSA--------------------NS-VVSPRLNFST---- IRAKg_h_Smoe -QG-YWLEPYWTIKN-DNQSNSA--------------------V---SPPRLNFSTTGML IRAKg_k-2_Smoe --TNDTSREYWTSGAWNGKIFSL-----------------------V-PQ-MTDNYLYTF IRAKg_r-2_Smoe --KLEIPQKYWSIAN-PTLNSTMTCLDDETGEHVLNNNACQPDRSLKFPAVLNLSSQGVL IRAKg_m-1_Smoe NKKFVIPQRYWYIAN-PAVNSSQTCLIDDTGEQVNSNIQCQTDGSLRFPAVLNLSSDGVL IRAKg_u-1_Smoe -QDY-LNQSYWGIIN-KQLNTSE--------------------STMTSTPKFTFSIDGHL IRAKg_c_Smoe AVPESNSQSYWDVQR-SPTSSNN-----------------------A--STLVMNSTGIL IRAKg_o-1_Smoe -DGFSANESYWSVLN-KDLDVTM--------------------K--NSIPRLTFNRNGSL IRAKg_m-2_Smoe NKKFVIPQRYWYIAN-PAVNSSQTCLIDDTGEQVNSNIQCQTDGSLRFPAVLNLSSDGVL IRAKg_o-2_Smoe -DGFSANESYWSVLN-KDLDVTM--------------------K--NSIPRLTFNRNGSL IRAKg_e-1_Smoe TFTDASNVS----------NY-QYSLDFTFANTRVMRMLKLEPSGNLRIYGLSTDN--SS IRAKg_d-2_Smoe SFFDGNGSSWKNPDKVYDTAQ-RYALDY--PEIGLTRRLTLDDDGNLRIYTLDEIK--NR IRAKg_r-1_Smoe SFYDATGKSWASG---SMSSQ-DYALDY--DDANVLRRLTLDDDGNLRIYSFGPKNKSGS IRAKg_d-1_Smoe SFFDGNGSSWKNPDKVYDTAQ-RYALDY--PEIGLTRRLTLDDDGNLRIYTLDEIK--NR IRAKg_f_Smoe TFTDGQGPWYIN---REQNSY-FYVLDF--GTPKVARRLTLERNGTLRVYSLTQDN--SS IRAKg_e-2_Smoe TFTDASNVS----------NY-QYSLDFTFANTRVMRMLKLEPSGNLRIYSLSTDN--SS IRAKg_o_Smoe SFYDATGKSWASG---SMSSQ-DYALDY--DDANVLRKLMLDKR---------------- IRAKg_v_Smoe ------------------------------------------------------------ IRAKg_s_Smoe ------------------------------------------------------------ IRAKg_q_Smoe ------------------------------------------------------------ IRAKg_a-1_Smoe NLNA-----------TSTVRQ-FFPEDY--G-PGQSRRLTLDDDGNLRLYTLI--E--AV IRAKg_a-2_Smoe NLNA-----------TSTVRQ-FFPEDY--G-PGQSRRLTLDDDGNLRLYTLI--E--AV IRAKg_g_Smoe ------------------------------------------------------------ IRAKg_u-2_Smoe AFFDANGSSWYRY--KFDNAQ-KYPIDL--GDTSVTRRLTLEKNGTLRSYSCGSRE--KR IRAKg_p_Smoe -------------------------------------------------HDL--EE--QE IRAKg_b_Smoe SFFDGNGSSWKNPDKVYDTAQ-RYALDY--PKVGLTRRLTLDDDGNLRIYTLDEIK--KR IRAKg_n-2_Smoe SFFDGSGSSWKNPVKVYDTAQ-RYALDY--PKVGLTRRLTVDDDGNLRIYTLDEIN--KR IRAKg_k-1_Smoe IFNA-----------TNPPSFTWFE-----K-SFQHSIFRLGHDGRIEVKQLDG-N--GN IRAKg_n-1_Smoe SFFDGSGSSWKNPVKVYDTAQ-RYALDY--PKVGLTRRLTVDDDGNLRIYTLDEIN--KR IRAKg_h_Smoe SFFDGNGSSWKNPDKVYDTAQ-RYALDY--PKVGLTRRLTLDDDGNLRIYTLDEIK--KR IRAKg_k-2_Smoe IFNA-----------TNPPSFTWFE-----K-SFQHSIFRLGHDGRIEVKQLDG-N--GN IRAKg_r-2_Smoe SFYDATGKSWASG---SMSSQ-DYALDY--DDANVLRRLTLDDDGNLRIYSFGPKNKSGS IRAKg_m-1_Smoe SYYDATGIA-------TENSH-KYALDY--GISNVLRRLKLDDDGNLRMYSFSNDT--RS IRAKg_u-1_Smoe AFFDANGSSWYRY--KFDNAQ-KYPIDL--GDTSVIRRLTLEKNGMLRSYSCGSGE--KR IRAKg_c_Smoe TFTDGQGPWYIN---REQNSY-FYVLDF--GTPKVARRLTLERNGTLRVYSLTQDN--SS IRAKg_o-1_Smoe EFFDANGSSWYRY--KYDNAQ-RYPIDY--GNSSVLRRLTLEKNGTLRSYSTYGER--SL IRAKg_m-2_Smoe SYYDATGIG-------TENSH-KYALDY--GISNVLRRLKLDDDGNLRMYSFSNDT--RS IRAKg_o-2_Smoe EFFDANGSSWYRY--KYDNAQ-RYPIDY--GNSSVLRRLTLEKNGTLRSYSTYGER--SL IRAKg_e-1_Smoe WNIVWQAMLLE--CQIHGVCGPFGLCTYAPR---------STCVCPPGFHFIDPQDHH-- IRAKg_d-2_Smoe WLITWQAVLLE--CDIFGKCGRFGICTYRPT---------ATCICPPGFHPTNASDPS-- IRAKg_r-1_Smoe WSVVWQAVMLE--CDIFGTCGPFALCTYRPT---------KICSCPPGFHRVDPNDES-- IRAKg_d-1_Smoe WLITWQAVLLE--CDIFGKCGRFGICTYRPT---------ATCICPPGFHPTNASDPS-- IRAKg_f_Smoe WNIVWQALTAD--CKVFGMCGPFGICTYRPG---------LVCTCPPGFHFVDPGDHS-- IRAKg_e-2_Smoe WNIVWQAMLLE--CQIHGVCGPFGLCTYAPR---------STCVCPPGFHFIDPQDHH-- IRAKg_o_Smoe W----------------------------------------------------------- IRAKg_v_Smoe ------------------------------------------------------------ IRAKg_s_Smoe ------------------------------------------------------------ IRAKg_q_Smoe ------------------------------------------------------------ IRAKg_a-1_Smoe WSARWQAVSDQ--CQVYNYCGNYGICSYRAVPSQAPVAYRTVCDCPTGLGFVDPSRR--- IRAKg_a-2_Smoe WSARWQAVSDQ--CQVYNYCGNYGICSYRAVASQAPLVYRTVCDCPTGLGFVDPSRR--- IRAKg_g_Smoe ------------------------------------------------------------ IRAKg_u-2_Smoe WRVVWQSALLE--CEVFGTCGAFGLCGYKPR---------KSCSCPPGFYAVDSSE-S-- IRAKg_p_Smoe WLLEHRLASRHARVRRPGTCGPFALCTYRPT---------KTCSCPPGFHRVDPNDES-- IRAKg_b_Smoe WIITWQAVLLE--CDIFGKCGRFGICAYRPT---------ATCICPPGFHPTNASDPS-- IRAKg_n-2_Smoe WIITWQAVLLE--CNIFGKCGRFGICTYRPT---------ATCTCPPGFHPTNASDSS-- IRAKg_k-1_Smoe WYTPWAVPANI--CDVTSLCGSNSVCSSSLN---------PPCSCPTGSSPSNDTNWRT- IRAKg_n-1_Smoe WIITWQAVLLE--CNIFGKCGRFGICTYRPT---------ATCTCPLGFHPTNASDSS-- IRAKg_h_Smoe WIITWQAVLLE--CDIFGKCGRFGICAYRPT---------ATCICPPGFHPTNASDPS-- IRAKg_k-2_Smoe WYTPWAVPANI--CDVTSLCGSNSVCSSSLN---------PPCSCPTGSSPSNDTNWRT- IRAKg_r-2_Smoe WSVVWQAVMLE--CDIFGTCGPFALCTYRPT---------KICSCPPGFHRVDPNDES-- IRAKg_m-1_Smoe WSIVWQALMQE--CDVFGACGAFGLCTYRPK---------KTCSCPPGFHRVDPIDDS-- IRAKg_u-1_Smoe WRVVWQSALLE--CEIFGTCGAFGLCGYKPR---------KSCSCPPGFHAVDSSE-S-- IRAKg_c_Smoe WNIVWQALTAD--CKVFGMCGPFGICTYRPG---------LVCTCPPGFHFVDPGDHS-- IRAKg_o-1_Smoe WRVVWQSLLLE--CDVFGTCGNFGLCKYQPR---------KSCVCPPGFHTVRDRSSGQL IRAKg_m-2_Smoe WSIVWQALMQE--CDVFGACGAFGLCTYRPK---------KTCSCPPGFHRVDPIDDS-- IRAKg_o-2_Smoe WRVVWQSLLLE--CDVFGTCGNFGLCKYQPR---------KSCVCPPGFHTVRDRSSGQL IRAKg_e-1_Smoe ----QGCTYDVPLQLSCNGSSN-----HHDWVRVDRASYNGNDYVKD--LSPTSLEGCRR IRAKg_d-2_Smoe ----QDCVYNTPLT-KCPAGQNSTDPRNFKMIQLVRTDFQYNDYNSHPLPNPSSQEDCIQ IRAKg_r-1_Smoe ----KGCDYDIPLG-ACQNSPN-----SVKLVQVNRADYYFNDYNFD--SSIKSLEKCKD IRAKg_d-1_Smoe ----QDCVYNTPLT-KCPTGQNSTDPRNFKMIQLVRTDFQYNDYNSHPLPNPSSQEDCIQ IRAKg_f_Smoe ----KGCEYNVPLK-SCNGSD-------NRWVRLERTDYTYNDKTY---ISVISLEDCKS IRAKg_e-2_Smoe ----QGCTYDVPLQLSCNGSSN-----HHDWVRVDRASYDGNDYVKD--LSPTSLEGCRR IRAKg_o_Smoe ------------------------------------------------------------ IRAKg_v_Smoe ------------------------------------------------------------ IRAKg_s_Smoe ------------------------------------------------------------ IRAKg_q_Smoe ------------------------------------------------------------ IRAKg_a-1_Smoe ---NAGCTNTGNVASDCATESN-------QLIATNSTAWLDSGS---TVTSNSNSEQCTS IRAKg_a-2_Smoe ---NAGCTNTGNVASDCATESN-------QLIATNFTAWLESGS---TVTSNSNSEQCTS IRAKg_g_Smoe ------------------------------------------------------------ IRAKg_u-2_Smoe ----AGCVRKFPLS--CSSGNATS--SASKMVEVQRAMYVGNLLQQL-SKDPISLEQCKV IRAKg_p_Smoe ----KGCDYDIPLG-GCQNSSN-----SVKLVQVNRADYYFNDYNFD--SAIKSLEKCKD IRAKg_b_Smoe ----QDCAYNTPLT-ECPTGQNSTDPRNFKMIQLVRTDFQYNDYNSHPLPSPSSQEDCIQ IRAKg_n-2_Smoe ----QDCAYNTPLA-KCPTGQNSTDPRNFKLIQLVRTDFKYNDYNSDPLPTPSSQEDCIQ IRAKg_k-1_Smoe EDWAEGCTALSSQ-ARRS------------------------------------------ IRAKg_n-1_Smoe ----QDCAYNTPLA-KCPTGQNSTDPRNFKLIQLVRTDFKYNDYNSDPLPTPSSQEDCIQ IRAKg_h_Smoe ----QDCAYNTPLT-KCPTGQNSTDPRNFKMIQLVRTDFQYNDYNSHPLPSPSSQEDCIQ IRAKg_k-2_Smoe EDWAEGCTALSSQ-ARRS------------------------------------------ IRAKg_r-2_Smoe ----KGCDYDIPLG-ACQNSPN-----SVKLVQVNRADYYFNDYNFD--SSIKSLEKCKD IRAKg_m-1_Smoe ----QGCDYNVPMD--CEH--------PTKLVLATRADYYYSDYRFD--AAVTTLEQCKA IRAKg_u-1_Smoe ----AGCVRNFPLS--CSSGNATS--SASKMVEVQRAMYVGNLLQQL-SKDPISLEQCKV IRAKg_c_Smoe ----KGCEYNVPLK-SCNGSD-------NRWVRLERTDYTYNDKTY---ISVISLEDCKS IRAKg_o-1_Smoe DGDFPGCSYNFPLN--CS---------NSKMVELARADFLGSGYIVG-LNSSMSLEQCKK IRAKg_m-2_Smoe ----QGCDYNVPMD--CEH--------PTKLVLATRADYYYSDYRFD--AAVTTLEQCKA IRAKg_o-2_Smoe DGDFPGCSYNFPLN--CS---------NSKMVELARADFLGSGYIVG-LNSSMSLEQCKK IRAKg_e-1_Smoe RCDRDCGCLGFVYRV-DRHGTCYTKGPAPG-----VIYNGFQIPSDEMAPSLVFLKVSTA IRAKg_d-2_Smoe RCLRECECLGAAFQM-GGAGICWLKGLDPS-----GLFNGKQSVD---VDNVFFLKVSAK IRAKg_r-1_Smoe TCMQDCKCLAAAYKY-DGTGLCFLKGNS-N-----KLYNGKQTLN---EMNMVFMKLSSL IRAKg_d-1_Smoe RCLRECECLGAAFQM-GGAGICWLKGLDPS-----GLFNGKQSVD---VDNVFFLKVSAK IRAKg_f_Smoe LCKENCGCLGIAYRA-DGSGQCFLKGPDSTRGPKQVIYNGFQIAS---GPNLFFLKVSAS IRAKg_e-2_Smoe RCDRDCGCLGFVYRV-DRHGTCYTKGSAPG-----VIYNGFQIPSDEMAPSLVFLKVSTA IRAKg_o_Smoe ------------------------------------------------------------ IRAKg_v_Smoe ------------------------------------------------VAALIFIKQRFL IRAKg_s_Smoe ------------------------------------------------------------ IRAKg_q_Smoe ------------------------------------------------------------ IRAKg_a-1_Smoe NCRGDSSCFGCLVPN-DGSGHCVQFRST--------SMSGYSSPS---IQSTAFLKVCTS IRAKg_a-2_Smoe NCRGDSSCFGCLVPN-DGSGHCVQFRST--------SMSGYSSPS---IRSTAFLKVCTS IRAKg_g_Smoe ------------------------------------------------------------ IRAKg_u-2_Smoe SCLKDCRCLGATYML-AGTKRCSLLGGEDG-----RLFNGVQAME---RASIALLKVSAL IRAKg_p_Smoe TCMQDCKCLAAAYKY-DGTGLCFLKGSS-N-----KLYNGKQTLN---EINMVFMKLSSL IRAKg_b_Smoe RCLRECECLGAAFQM-GGAGICWLKGLDPS-----GLFNGKQSVD---VDNVFFLKVSAK IRAKg_n-2_Smoe RCLRECECLGAAFQM-AGAGICWLKGLDPS-----GLFNGKQSLD---VDNVFFLKLSAK IRAKg_k-1_Smoe ------------------------------------------------------------ IRAKg_n-1_Smoe RCLRECECLGAAFQM-AGAGICWLKGLDPS-----GLFNGKQSLD---VDNVFFLKLSAK IRAKg_h_Smoe RCLRECECLGAAFQM-GGAGICWLKGLDPS------------------------------ IRAKg_k-2_Smoe ------------------------------------------------------------ IRAKg_r-2_Smoe TCMQDCKCLAAAYKY-DGTGLCFLKGNS-N-----KLYNGKQTLN---EMNMVFMKLSSL IRAKg_m-1_Smoe NCLKDCQCLAAAYKAQDGDSLCFLKGGQ-D-----RLYNGMQSFD---KPNLVYMKVSIN IRAKg_u-1_Smoe SCLKDCRCLGATYML-AGTKRCSLLGGEDG-----RLFNGVQAME---RTSIALLKVSAL IRAKg_c_Smoe ICKENCGCLGIAYRA-DGSGQCFLKGPDSTRGPKQVIYNGFQIAS---GQNLFFLKISAS IRAKg_o-1_Smoe LCLDDCQCVGAAYTL-DGSGQCRLRKGG-S-----TPYNIVQSPQ---KASIALIKLSAS IRAKg_m-2_Smoe NCLKDCQCLAAAYKAQDGDSLCFLKGGQ-D-----RLYNGMQSFD---KPNLVYMKVSIN IRAKg_o-2_Smoe LCLDDCQCVGAAYTL-DGSGQCRLRKGG-S-----TPYNIVQSPQ---KASIALIKLSAS IRAKg_e-1_Smoe SRVQPEA-P---LNELFSTIVNATNVKSYAELKQVREAF----KLVIPAAIAAAELLLFL IRAKg_d-2_Smoe DPGQSPD------ANVYVTNANATVVPGFQWLVLHRPFFR--DGPRIALFITTLVLMVFL IRAKg_r-1_Smoe DTSAADD-QH----DPFLADANATVSDQAMPKINKRTVYLSRHLQSIILSVAIVEFGLFA IRAKg_d-1_Smoe DPGQNG--------------------------------------PRIALFITTLVLMVFL IRAKg_f_Smoe DTSVPAEDDHSLNQLLYVTDMDATNNVETLFV--KEVEVP--IKHKLAVALAIAELLVFL IRAKg_e-2_Smoe SSFQPEA-P---LNQLFSTIVNATNVKSYAELKQVREAF----KLVIPAAIAAAELLLFL IRAKg_o_Smoe ------------------------------------------------------------ IRAKg_v_Smoe DPRAKA------------------------------------------------------ IRAKg_s_Smoe ------------------------------------------------------------ IRAKg_q_Smoe ------------------------------------------------------------ IRAKg_a-1_Smoe AANSPPT-S--VS---------------------SEPR-SSNQGRAIGIAVGVTVAALVL IRAKg_a-2_Smoe AANSPPT-S--VL---------------------SEPG-SSNQGRAIGIAVGVTVAALVL IRAKg_g_Smoe ------------------------------------------------------------ IRAKg_u-2_Smoe DPLTTSF-SE----DVFVTVLDAYTPSLPD-SLRNWSYFS-DAGHRLVFAIAIGELASFL IRAKg_p_Smoe DTSAADD-QH----DPFLADANATVSDQVMRKINKWTVYLSR--HPIILSVAIVELGLFA IRAKg_b_Smoe DPGQSPD------ANIYVTNANATVVPGFQWLVLHRSFFR--DTPRVALFITTLVLMVFL IRAKg_n-2_Smoe DPGKSPD------ANIYVTNANATVVPGFQWLVIHRPFFR--DAPRVALFITTLVLVVFL IRAKg_k-1_Smoe ----------------------------------------SSKNSGVAIGVGAGIVLLLL IRAKg_n-1_Smoe DPGQSPD------ANIYVTNANATVVPGFQWLVIHRPFFR--DAPRVALFITTLVLVVFL IRAKg_h_Smoe ------------------------------------------------------------ IRAKg_k-2_Smoe ----------------------------------------SSKNSGVAIGVGAGIVLLLL IRAKg_r-2_Smoe DTSAADD-QH----DPFLADANATVSDQVMPKINKRTVYLSRHLQSIILSVAIVEFGLFA IRAKg_m-1_Smoe DKLAADD-HY----DYFMSNTNATLSNIFTAH-HKE-SYLSMHLHSVVIAIATAELVAFA IRAKg_u-1_Smoe DPLTTSF-SE----D------------------------------VLVFAIAIGELASFL IRAKg_c_Smoe DTSVPAEDDHSLNQLLYVTDMDATNNMETLFV--KEVEVP--IKHKLAVALAIAELVVFL IRAKg_o-1_Smoe DTRAQAD-PN-DMKNLFVTSMNASDLYQADSRKSSGTKFF-TASRALVFGVAVGEFVILC IRAKg_m-2_Smoe DKLAADD-HY----DYFMSNTNATLSNIFTAH-HKE-SYLSMHLHSVVIAIATAELVAFA IRAKg_o-2_Smoe DTRAQAD-PN-DMKNLFVTSMNASDLYQADSRKSSGTKFF-TASRALVFGVAVGEFVILC IRAKg_e-1_Smoe AAGVIWWLYTE--K-RIKRLSQ----------ALDQVDGVVTKFTYHQLEVATGNFKDKL IRAKg_d-2_Smoe LVTCFMGLCWIISA-RVRNNIM----------DL-DFGSGPAIFTYQQLQNFTDNFYDRL IRAKg_r-1_Smoe TGAAIVAAVWKKTS-RKKWEEM----------TA-EIEGLPTKFTYRQLQDATDNFRDEL IRAKg_d-1_Smoe LVTCFMGLCWIISA-RARNNMM----------DL-DFGSGPAIFTYQQLQNFTDNFYDRL IRAKg_f_Smoe ICGAVYGHHVKEKV---RHIRQ----------QM-EFEGGTTRFTYHQLEIATNFFKDKL IRAKg_e-2_Smoe AAGVIWWLYTE--K-RIKRLSQ----------ALDQVDGVVTKFTYHQLELATGNFKDKL IRAKg_o_Smoe ------------------------------------------------------------ IRAKg_v_Smoe -------------------STTA------ASIISAPGSPQLVQFSFKAIVATTRNFSDKI IRAKg_s_Smoe ------------------------------------------------------------ IRAKg_q_Smoe ------------------------------------------------------------ IRAKg_a-1_Smoe AELAVGWAVYRRRY-SRRVQEAA------RHAILDYASGAPMRFTYKELQNATYNFQTRI IRAKg_a-2_Smoe AELAVGWAVYRRRY-SRRVQEAA------RHAILDYASGAPMRFTYKELQNATYNFQTRI IRAKg_g_Smoe ------------------------------------------------------------ IRAKg_u-2_Smoe CIALSAWFCWRRSL-RGMWKKA----------AK-DH-RGPTWFSYEQLEVATNHFSCKL IRAKg_p_Smoe TGAAVVAAVWTKTS-RRKWEEM----------TG-EIEGLPTKFTYRQLQDATDNFRNEL IRAKg_b_Smoe LVTCFLGLSWIIST-RARNNIM----------DL-DFGSGPARFTYQQLQNFTDNFCDKL IRAKg_n-2_Smoe LV---VGLCWTISA-RARNNMM----------DL-DFSSGPARFTYQQLQTFTDNFCDKL IRAKg_k-1_Smoe AGL-AAFVIARRRRKAKRVSSSSGSSKSDQRSIYNFVDGELANFTFKQLHAATDGFKKRL IRAKg_n-1_Smoe LV---VGLCWTISA-RARNNMM----------DL-DFSSGPARFTYQQLQTFTDNFCDKL IRAKg_h_Smoe ----------------ARNNIM----------DL-DFGSGPARFTYQQLQNFTDNFCDKL IRAKg_k-2_Smoe AGL-AAFVIARRRRKAKRVSSSSGSSKSDQRSIYNFVEGELANFTFKQLHAATDGFKKRL IRAKg_r-2_Smoe TGAAIVAAVWKKTS-RKKWEEM----------TA-EIEGLPTKFTYRQLQDATDNFRDEL IRAKg_m-1_Smoe AIGVAMFSMWKRRS-RKEWEAL----------TA-EIEGSPTKFTYKQLQEATNNFEETL IRAKg_u-1_Smoe CIALSAWFCWRRSL-REMWKKA----------AK-DH-RGPTWFSYEQLEVATNHFSCKL IRAKg_c_Smoe ICGAVYGHHVKEKV---RHIKQ----------QM-EVEGGATRFTYHQLEIATNFFKDKL IRAKg_o-1_Smoe CVVIATSMCWRRSN-KKMWNKH----------AG-DH-HGPTRFSYEQLEIATGNFRHKL IRAKg_m-2_Smoe AIGVAMFSMWKRRS-RKEWEAL----------TA-EIEGSPTKFTYKQLQEATNNFEETL IRAKg_o-2_Smoe CVVIATSMWWRRSN-KKMWNKH----------AG-DH-HGPTRFSYEQLEIATGNFRHKL IRAKg_e-1_Smoe GAGAFGTVYKGVL--ADGTSLVAVKSLMM-ATHAEKQFKAEVATLGKIHHINLVRMLGYC IRAKg_d-2_Smoe GSGGFGTVYKGRL--PNG-TLVAVKELEM-AMQADKQFQAEVKTLGKIHHINLVRLLGYC IRAKg_r-1_Smoe GSGGFGSVYRGNI--PEKGGIVAVKKITT-VNQAKKQFKAEVSTIGRVHHVNLVRLLGYC IRAKg_d-1_Smoe GSGGFGTVYKGRL--PNG-TLVAVKELEM-AMQADKQFQAEVKTLGKIHHINLVRLLGYC IRAKg_f_Smoe GTGGFGTVFKGLL--PDG-IIVAVKNIEM-EIQAEKQFQAEVTTLGNIHHINLVRLLGYS IRAKg_e-2_Smoe GAGAFGTVYKGVL--ADGTSLVAVKSLMM-ATHAEKQFKAEVATLGKIHHINLVRMLGYC IRAKg_o_Smoe -----------------------------------QSQDAEVSTIGRVHHVNLVRLLGYC IRAKg_v_Smoe GAGILGSVYKGVF--PDSETVVAVKKLEI-N-TSDRDFRNCVSEIGFLSHDSLVQLHGFC IRAKg_s_Smoe -----------------------------------------VTTLGRVHHVNLVKLLGYC IRAKg_q_Smoe ---------------------------------------ARNTTLGRVHHVNLVKLLGYC IRAKg_a-1_Smoe GEGGFGPVYKGSLALPVSKTAIAVKKLEG-IFQGEKEFRTEVATIGSTHHMNLMRLVGFC IRAKg_a-2_Smoe GEGGFGPVYKGSIALPVSKTAIAVKKLEG-IFQGEKEFRTEVATIGSTHHMNLMRLVGFC IRAKg_g_Smoe ----------------------------------------EDATLGKIHHISLVRMLGYC IRAKg_u-2_Smoe GAGGFGSVYKGVL--PDM-TVVAVKTLEGAASHGEKQFKAEVATLGRVHHVNLVKLLGYC IRAKg_p_Smoe GSGGFESVYRGNI--PEKGGIVAVKKITT-VNQAEKQCKAEVSTIGRVHHVNLVRLLGYC IRAKg_b_Smoe GSGGFGTVYKGRL--PNG-TLVAVKELEM-AMQADKQFQAEVKTLGKIHHINLVRLLGYC IRAKg_n-2_Smoe GSGGFGTVYKGRL--LNG-TLVAVKELEM-AMQADKQFQTEVETLGKIHHINLVRLLGYC IRAKg_k-1_Smoe GSGGFGEVFKGSI--Q--GQAVAVKRLIK------------------------------- IRAKg_n-1_Smoe GSGGFGTVYKGRL--LNG-TLVAVKELQM-AMQADKQFQTEVETLGKIHHINLVRLLGYC IRAKg_h_Smoe GSGGFGTVYKGRL--PNG-TLVAVKELEI-AMQADKQFQAEVKTLGKIHHINLVRLLG-- IRAKg_k-2_Smoe GSGGFGEVFKGSI--Q--GQAVAVKRLIK------------------------------- IRAKg_r-2_Smoe GSGGFGSVYRGNI--PEKGGIVAVKKITT-VNQAKKQFKAEVSTIGRVHHVNLVRLLGYC IRAKg_m-1_Smoe GSGGYGTVYRGEI--PEKGGIVAVKVIKA-VTHAEKQFKAEVNTIGKVHHVNLVRLLGYC IRAKg_u-1_Smoe GAGGFGSVYKGVL--PDM-TVVAVKTLEGAASHGEKQFKAEVATLGRVHHVNLVKLLGYC IRAKg_c_Smoe GTGGFGTVFKGLL--PDG-IIVAVKNIEM-EIQAEKQFQAEVTTLGKIHHINLVRLLGYC IRAKg_o-1_Smoe GSGGFGSVYKGVL--PDK-TVVAVKTLEV-ATHGENQFKAEVATLGTIHHVNLVKLLGYC IRAKg_m-2_Smoe GSGGYGTVYRGEI--PEKGGIVAVKVIKA-VTHAEKQFKAEVNTIGKVHHVNLVRLLGYC IRAKg_o-2_Smoe GSGGFGSVYKGVL--PDK-TVVAVKTLEV-ATHGENQFKAEVATLGTIHHVNLVKLLGYC IRAKg_e-1_Smoe AEGS--HRLLVYEYMENSSLEKVLS-QV--------------PKTLCEWKTRLAIALGIS IRAKg_d-2_Smoe YEDN--RKLLVYEYMPNGSLEKLLFLND--------------TEHFCGWASRFNIALGIA IRAKg_r-1_Smoe AEGD--HHLLVYEFMPNGSLDHHLSASSSF---------AASQEIFSTWETRHSIALGIA IRAKg_d-1_Smoe YEDN--RKLLVYEYMPNSSLEKLLFLND--------------TEHFCGWASRFNIALGIA IRAKg_f_Smoe GQSR--K----------------------------------------------------- IRAKg_e-2_Smoe AEGS--HRLLVYEYMANSSLEKVLS-QV--------------PQTLCEWKTRLAIALGIS IRAKg_o_Smoe AEGG--CHLLVYEFMPNGSLDHHLSASSSF---------AASQEIFSTWETQHSIALGIA IRAKg_v_Smoe ADCGPDNKMLVYEFLSNGSLDKLLFED--------------SEDNRLDWKFRFDTALSIA IRAKg_s_Smoe AEGS--HRLLVYEFLSNGSLDQDLST---------------------KLVCRFSIALGVA IRAKg_q_Smoe AEGS--HRLLVYEFLSNGSLDQECID---------------------LWGTRFSIALGVA IRAKg_a-1_Smoe AEGA-ATRLLVYEFLPNGSLDRFLFQPLAPGEDED--DSYQEARPSLDWPTRFKIALGTA IRAKg_a-2_Smoe AEGA-ETRLLVYEFLPNGSLDRFLFQPLAPGEDED--DSYQGARPSLDWPTRFKIALGTA IRAKg_g_Smoe AEGS--HRLLVYEYMANSLQVDEASSQI--------------PQTLCKWKTRLAIALSIS IRAKg_u-2_Smoe AEGS--HRLLVYEFLSNGSLDQECID---------------------LWGTRYSIALGVA IRAKg_p_Smoe AEGD--RHLLVYQFMTNGSLDHHLSASSSS---------AASQEIFSTSETQHSIALGIA IRAKg_b_Smoe YEDN--RKLLVYEYMPNGSLDKLLFL--------------------DSWASRFNIALGIA IRAKg_n-2_Smoe YEDN--RKLLVYEYMPNGSLEKLLFLDD--------------AKHFCSWANRFSIALGIA IRAKg_k-1_Smoe -----LQRLLVYEFIERGSLDRTLFNRD------------AENSVVLSWSQRFGIALGTA IRAKg_n-1_Smoe YEDN--RKLLVYEYMPNGSLEKLLFLDD--------------AKHFCSWASRFSIALGIA IRAKg_h_Smoe ------------------------------------------------WASRFNIALGIA IRAKg_k-2_Smoe -----LQRLLVYEFVERGSLDRTLFNRD------------AENSVVLSWSQRFGIALGTA IRAKg_r-2_Smoe AEGD--HHLLVYEFMPNGSLDHHLSASSSF---------AASQEIFSTWETRHSIALGIA IRAKg_m-1_Smoe VEGV--HRLLVYEFMPNGSLDNYLSSNS--------------GSSDSSWQTRFSIALGIA IRAKg_u-1_Smoe AEGS--HRLLVYEFLSNGSLDQECSD---------------------LWGTRYSIALGVA IRAKg_c_Smoe AEGS--HRLLVYEYMQNGSLEKSIISNE------------DIDESLCDWKTRFSIAVGIA IRAKg_o-1_Smoe VEGS--HRVLVYEYMTNGSLDKVLTSIRAPWKTRYCHRKSQSPKVKLTLLFRYSIAMGIA IRAKg_m-2_Smoe VEGV--HRLLVYEFMPNGSLDNYLSSNS--------------GSSDSSWQTRFSIALGIA IRAKg_o-2_Smoe VEGS--HRVLVYEYMTNGSLDKVLTSIRAPWKTRYCHRKSQSPKVKLTLLFRYSIAMGIA IRAKg_e-1_Smoe RGITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRESSANVTTARGTRGY IRAKg_d-2_Smoe RGITYLHDECQECILHCDIKPQNILLDESFIPKVADFGLAKLMKRERELSVTTVRGTRGY IRAKg_r-1_Smoe KGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKE-SMSITTVQGTRGY IRAKg_d-1_Smoe RGITYLHDECQECILHCDIKPQNILLDESFIPKVADFGLAKLMKRERALSVTTVRGTRGY IRAKg_f_Smoe -----------------------------------------NHKRDHGARNSRIHGTG-- IRAKg_e-2_Smoe RGITYLHEQCQECIIHCDIKPQNILLDDNFRPKVSDFGLAKLMKRESSANVTTARGTRGY IRAKg_o_Smoe KGLTYLHEKCGERIVHCDIKPQNVLLDESSGQRCPTLGW--------------------- IRAKg_v_Smoe RGVAHLHQQ-QVPVIHGNLKTENILLDKNFQPKISDTGLGLLVDRRKIKTALSSGRVHGY IRAKg_s_Smoe KRITYLHKECYDCILR-DIKPQNILLHENFCPKVSDFGLAKLIDKERALDVTTIRGTRGY IRAKg_q_Smoe KGITYLHE-CYDCILR-DIKPQNILLDENFCPKVLDFGLAKLIDKERALDVTTIRGTRGY IRAKg_a-1_Smoe RALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGNARNLTTVRGTRGY IRAKg_a-2_Smoe RALAYLHEECREPIVHCDLKPENILLDDSFAPKVSDFGLARLIDEGNARNLTTVRGTRGY IRAKg_g_Smoe RGITYLHQQCQECIIHCDVKPQNILFDDNFHPKVSDFGLAKLMKRESSANVTTARDTRGY IRAKg_u-2_Smoe KGITYLHEECYDCVLHCDIKPQNVLLDENFCPKVSDFGLAKLIDKERALDVTTIRGTRGY IRAKg_p_Smoe KGLTYLLWRAHRPLRYQATK------RAAGRPKVADFGLARMMRKE-SMSVTTVQGTRGY IRAKg_b_Smoe RGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSVTTVRGTRGY IRAKg_n-2_Smoe RGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSVTTVRGTRGY IRAKg_k-1_Smoe KGLAYLHEDCRHRIIHCDIKPENILLDAEMKPKIADFGLAKLLGREFSRVVTSMRGTRGY IRAKg_n-1_Smoe RGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALSVTTVRGTRGY IRAKg_h_Smoe RGITYLHDECQECILHCDIKPQNILLDESFCPKVADFGLAKLMKRERALK---------- IRAKg_k-2_Smoe KGLAYLHEDCRHRIIHCDIKPENILLDAEMKPKIADFGLAKLLGREFSRVVTSMRGTRGY IRAKg_r-2_Smoe KGLTYLHEKCGERIVHCDIKPQNVLLNESFRPKVSDFGLARMMTKE-SMSITTVQGTRGY IRAKg_m-1_Smoe KGIAYLHEECQECIIHCDIKPQNILLDDQMSPKIADFGLAKLTKREHSMSVTTVRGTRGY IRAKg_u-1_Smoe KGITYLHEECYDCILHCDIKPQNVLLDENFCPKVSDFGLAKLTDKERALDVTTIRGTRGY IRAKg_c_Smoe RGITYLHEQCQECIVHCDIKPQNILLDEKFCPKVSDFGLAKLASRERTINVTTVQGTRGY IRAKg_o-1_Smoe RGITYLHEECYECILHCDIKPQNILLDQNLCPKVADFGLAKLTKREMALNVTTIRGTRGY IRAKg_m-2_Smoe KGIAYLHEECQECIIHCDIKPQNILLDDQMSPKIADFGLAKLTKREHSMSVTTVRGTRGY IRAKg_o-2_Smoe RGITYLHEECYECILHCDIKPQNILLDQNLCPKVADFGLAKLTKKEMALNVTTIRGTRGY IRAKg_e-1_Smoe MAPEWISNVAITPKVDVYSFGMVLLELMSGRDKFMFTP-SAMNS----------GRWYFP IRAKg_d-2_Smoe LAPEWISNLPITTKVDVYSFGMVLLEIISGREKYLMTI-SAINS--------ENNRWCLS IRAKg_r-1_Smoe LAPEWLESQSITPKADVYSFGMLLLDILGGKRKALMEL-GSGDREYENAPLPPPREWYFP IRAKg_d-1_Smoe LAPEWISDLPITTKADVYSFGMVLLEIISGREKYLMTI-SAINS--------ENNRWCLS IRAKg_f_Smoe ----------MGPQRHHYSKGGRV------------------------------QLWH-- IRAKg_e-2_Smoe MAPEWISNVAITPKVDVYSFGMVLLELMSGRDKFMFTP-SAMNS----------GRWYFP IRAKg_o_Smoe ------------------------------------------------------------ IRAKg_v_Smoe FSPEWIADSPLTTKTDVYGFGMILLEIIGGRRILDLS----QKS----------EQWNFV IRAKg_s_Smoe MAPEWVGDRPITSKVDVYIYGMVLLELLSGNDKSRI-------S----------QNRYFP IRAKg_q_Smoe MAPVWVGDRPITSKVDVYSYGMVLLELLSGNDKSRI-------G----------QNRYFP IRAKg_a-1_Smoe MAPEWLANMPITAKSDVYSYGMVLLELVGGRRNFDTC--RAVPR----------GMQRYP IRAKg_a-2_Smoe MAPEWLANMPITAKSDVYSYGMVVLELVGGRRNFDTC--RAVPR----------GMQRYP IRAKg_g_Smoe MAPEWISMVAIAPKVDVYSFGMVLLG--SGRDKFMFF----------------------- IRAKg_u-2_Smoe MAPEWVGDRPITSKVDVYSYGMVLLELLSGNDKSRI-------G----------QNRYFP IRAKg_p_Smoe LAPEWLESQSITPKANVYSFGMLLLDILSGKRKALMEL-GSGDKEYE------------- IRAKg_b_Smoe LAPEWISNLPITTKVDVYSFGMVLLEIISGREKYLMTI-SAINS--------ENNRWCLS IRAKg_n-2_Smoe LAPEWISNLPITTKVDVYSFGMVLLEIISGREKYIMTI-SAINS--------ENSRWCLS IRAKg_k-1_Smoe LAPEWLSNMPITPKADVYSYGMTLLEIISGRRNIDF-----RND----------QIFFYP IRAKg_n-1_Smoe LAPEWISNLPITTKVDVYSFGMVLLEIISGREKYIMTI-SAINS--------ENSRWCLS IRAKg_h_Smoe -----------------------------------------------------NNRWCLS IRAKg_k-2_Smoe LAPEWLSNMPITPKADVYSYGMTLLEIISGRRNIDF-----RND----------QIFFYP IRAKg_r-2_Smoe LAPEWLESQSITPKADVYSFGMLLLDILGGKRKALMEL-GSGDKEYENAPLPPPREWYFP IRAKg_m-1_Smoe LAPEWLDGLSVTPKIDVYSFGMLLFDILSGTNKMIFNE-LAGTS-FE------SFPSGME IRAKg_u-1_Smoe MAPEWVGDRPITSKVDVYSYGMVLLELLSGNDKSRI-------G----------QNRYFP IRAKg_c_Smoe MAPEWVRNVTITPKVDVYSYGMVLFELLSGGKIIPVDGAPATNS----------ERGHFP IRAKg_o-1_Smoe LAPEWISNRPITTKVDVYSYGMVLLELLSGHDKSRS-------G----------QNTSFS IRAKg_m-2_Smoe LAPEWLDGLSVTPKIDVYSFGMLLFDILSGTNKMIFNE-LAGTS-FE------SFPSGME IRAKg_o-2_Smoe LAPEWISNRPITTKVDVYSYGMVLLELLSGHDKSRS-------G----------QNTYFS IRAKg_e-1_Smoe VWAFEQCATGNMKST-ADPRMA-ETIDWEQFEMALRVAFWCIQPEPESRPSMSKVVQMLE IRAKg_d-2_Smoe DWAYNMYQAGDLESI-IDKKLVREDVDLVQFKRLLKVALWCIQHDANARPSMGKVVQMME IRAKg_r-1_Smoe IYAFHKYMTSELESV-ADPNLASGSVDWEQFETALKIALSCIHQDPGSRPAMSRVVQILE IRAKg_d-1_Smoe DWAYNMYQAGDLESI-VDKKLVREEVDLVQFKRLLKVALWCIQHDANARPSMGKVVQMME IRAKg_f_Smoe --------------------------------GPLRAAEWRKNNSSRWRSCHE------- IRAKg_e-2_Smoe VWAFEQCATGNMKST-ADPRMA-ETIDWEQFEMALRVAFWCIQPEPESRPSMSRVVQMLE IRAKg_o_Smoe ------------------------------------------------------------ IRAKg_v_Smoe DWVSKQVKAGNYVGV-ADPRLS--SIDLEQLRRGIDVAVWCIQDDAKSRPSIAKVVEELE IRAKg_s_Smoe VWAFQKYVAGEQVELDASKRHLDHPLELVPL----------------------------- IRAKg_q_Smoe VWAFQKYVAGERVELDASKRHLDHPLELVPLQ----VFKPRVR---NGVDSSRPVVKMLE IRAKg_a-1_Smoe AYLYRELEAGRLEGA-VDERMYRADVDGVQLERVVKVAFWCIQDVASARPVMSKVVQMLE IRAKg_a-2_Smoe AYLYRELEAGRLEGA-VDERMYRADVDGVQLERVVKAAFWCIQDVASARPVMSKVVQMLE IRAKg_g_Smoe ------------------------------------------------------------ IRAKg_u-2_Smoe VWAFQKYVAGELHAI-ADPGLKN--LEWNEFERMIKVAFWCIQLDARSRPSMSRVVQMLE IRAKg_p_Smoe ------------------------------------------------------------ IRAKg_b_Smoe DWAYNMYQAGDLESI-VDKKLVQEEVNVVQFKRLLKVALWCIQHDANARPSMGKVVQMME IRAKg_n-2_Smoe DWAYNMYQAGDMESI-VDKKLVGEEVDFMQFKRLLKVALWCIQHDAHARPSMGKVVQMME IRAKg_k-1_Smoe LWAAEQVCNGEFSKL-PDDRLD--EWDEEELRRAARTAIWCVQDEEINRPSMKTVVQMLE IRAKg_n-1_Smoe DWAYNMYQAGDMESI-VDKKLVGEEVDFVQFKRLLKVALWCIQHDAHARPSMGKVVQMME IRAKg_h_Smoe DWAYNMYQAGDLESI-VDKKLVQEEVNVVQFKRLLKVALWCIQHDANARPSMGKVVQMME IRAKg_k-2_Smoe LWAAEQVCNGEFAKL-PDDRLD--EWDEEELRRAARTAIWCVQDEEINRPSMKTVVQMLE IRAKg_r-2_Smoe IYAFHKYMTSELESV-ADPTLASGSVDWGQFETALKIALSCIHQDPGSRPAMSRVVQILE IRAKg_m-1_Smoe D-YFQKYIASELQCI-ADPKMEMAETDWPQFKLLLKVALWCIQQNPSSRPSMSRIVQLLE IRAKg_u-1_Smoe VWAFQKYVAGELHAI-ADPGLKS--LEWNEFERMIKVAFWCIQLDARSRPSMSRVVQMLE IRAKg_c_Smoe IWAFQHYVAGSVSSI-ADTKMA-EKIDMVQFNMVLRVAFWCVQPDASLRPNMSKVVEMLE IRAKg_o-1_Smoe VWAFQKYMAGEFESI-VDPKLVT-SVEWSQFERMLKTAFWCIQLDANLRPSMSRVIQMLE IRAKg_m-2_Smoe D-YFQKYIASELQCI-ADPKMEMAETDWPQFKLLLKVALWCIQQNPSSRPSMSRIVQLLE IRAKg_o-2_Smoe VWAFQKYMAGEFESI-VDPKPVT-SVEWSQFERMLKTAFWCIQLDANLRPSMSRVIQMLE IRAKg_e-1_Smoe EN-APVPAPPLPRIFEDGGSGGVSR---------ELS---------VMYPSESGR IRAKg_d-2_Smoe DT-IQVPEPLSPNLSSEIAL-DPSM---------VPSL--------EVGSLTNGR IRAKg_r-1_Smoe GK-AEAPPPPFPDAGENDL-----------------F---------VALQTSTIC IRAKg_d-1_Smoe DT-VQVPEPLSPNLSSEIAL-DPS-----------------------VGSLTNGR IRAKg_f_Smoe -----LGTRAFS---------------------------------------NLGF IRAKg_e-2_Smoe EN-APVPAPPLPRIFEDGGS-GVSR---------ELS---------VMYPSESGR IRAKg_o_Smoe -----------------------------------------------------RG IRAKg_v_Smoe KVLV-IEATPARKKR-S------------------YGQ----------LQEIEAS IRAKg_s_Smoe ----QVF---KPR--S-----------------------------AMAWTAPGRA IRAKg_q_Smoe QPDLEVAVPPFPTPASEKVLSGNSP---------SFLP-------PLSQSVIDPG IRAKg_a-1_Smoe GNLA-VLLPPPPKVAMDSSASSS-GSATAASSSTAFSISSQSSGTSSAPHSLIGR IRAKg_a-2_Smoe GNLA-VLLPPPPKVAMDSSAASSSGSATATSSSTAFSISSQSSGTSSAPHSLIGR IRAKg_g_Smoe ---------------------------------------------------PSHE IRAKg_u-2_Smoe EPDLEVAVPPFPTPASEEVVSGNSP---------SFLP-------PLSQSVIDPR IRAKg_p_Smoe -N-APLPPP---------------------------------------GECSTSK IRAKg_b_Smoe DI-VQVPEPSSPNPSFEIAL-DPS-----------------------MDPSGSLR IRAKg_n-2_Smoe DT-VQFPEPSSPNSSFSIGL-DPSM---------DYSE-------DTIGSLTNGR IRAKg_k-1_Smoe GSATDFPDPVKPSS-FEMW------------------L----------EFQEQSG IRAKg_n-1_Smoe DT-VQFPEPSSPNSSFSIGL-DPSM---------DYSE-------DTVGSLTNGR IRAKg_h_Smoe DI-VQVPEPSSPNPSFEIAL-DPS-----------------------MDPSGSLR IRAKg_k-2_Smoe GRATDFPDPVKPSS-FEIW------------------L----------EFQEQSA IRAKg_r-2_Smoe GK-AEAPPPPFPDAGENDL-----------------F---------VALQTSTIC IRAKg_m-1_Smoe HN-DPE----------------------------------------NKIFDQDLC IRAKg_u-1_Smoe EPDLEVAVPPFPTPASEEVVSGNSP---------SFLP-------PLSQSVIDPR IRAKg_c_Smoe EN-VPVPEPPFP---------------------------------------RMIE IRAKg_o-1_Smoe DNSSEVAVPPFPTPLDHEAGTGNSS---------S-IP-------LETQSFLEAR IRAKg_m-2_Smoe HN-DPE----------------------------------------NKIFDQDLC IRAKg_o-2_Smoe DNSSELAVPPFPTPLDHEAGTGNSS---------S-IP-------LETQSFLEAR