CLUSTAL W (1.83) multiple sequence alignment JNK3_Hsap MSLHFLYYCSEPT---LDVK---------------------------------------- JNK2_Hsap M----------------------------------------------------------- JNK1_Hsap M----------------------------------------------------------- bsk_Dmel M----------------------------------------------------------- JNK3_Mmus MSLHFLYYCSEPT---LDVK---------------------------------------- JNK2_Mmus M----------------------------------------------------------- JNK1_Mmus M----------------------------------------------------------- jnk-1_Cele MEERLSTTSSYPSHPGRSVEEDHNTLLASSSISSIIRGTRGHLNNFIESVGNWLVPSSSG C49C3.10_Cele MQT--------------------------------------------------------- T07A9.3_Cele MEVDLPV----------------------------------------------------- Y51B9A.9_Cele M----------------------------------------------------------- ZC416.4_Cele MNLP-------------------------------------------------------- JNK_Spur MCEFDLHV-----QPIRSRQ-----------------------------------MAGT- AqueK127_Aque M----------------------------------------------------------- * JNK3_Hsap -------IAFCQGFDKQVDVSYIAKHYN----------MSKSKVDNQFYSVEV------G JNK2_Hsap ---------------------------------------SDSKCDSQFYSVQV------A JNK1_Hsap ---------------------------------------SRSKRDNNFYSVEI------G bsk_Dmel ---------------------------------------TTA--QHQHYTVEV------G JNK3_Mmus -------IAFCQGFDKHVDVSSIAKHYN----------MSKSKVDNQFYSVEV------G JNK2_Mmus ---------------------------------------SDSKSDGQFYSVQV------A JNK1_Mmus ---------------------------------------SRSKRDNNFYSVEI------G jnk-1_Cele RDDDAVSLDSCQSVYS-----PVRHHINSGTGGGILMEPSSIHVPENYYSVTI------G C49C3.10_Cele -----------------------------------------------YHEFQQ-----PN T07A9.3_Cele ---------------------------------------HNEYDASRFHQVTIRDPIAGA Y51B9A.9_Cele -----------------------------------------------FRQ-EI-----LN ZC416.4_Cele ---------------------------------------------SKFHQVTITDPIAGA JNK_Spur ------KLNHHQ-----------PNHHQ----------FNYHQLNSQFYHVTV------G AqueK127_Aque ---------------------------------------A------DFYTTQV------G . JNK3_Hsap DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP--FQNQTHAKRAYREL JNK2_Hsap DSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP--FQNQTHAKRAYREL JNK1_Hsap DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP--FQNQTHAKRAYREL bsk_Dmel DTNFTIHSRYINLRPIGSGAQGIVCAAYDTITQQNVAIKKLSRP--FQNVTHAKRAYREF JNK3_Mmus DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRP--FQNQTHAKRAYREL JNK2_Mmus DSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRP--FQNQTHAKRAYREL JNK1_Mmus DSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRP--FQNQTHAKRAYREL jnk-1_Cele EAQMVVLKRYQNLRLIGSGAQGIVCSAFDTVRNEQVAIKKLSRP--FQNVTHAKRAYREL C49C3.10_Cele GTFFTVPVRYVNVQPFQFD-KPFVVHAFDQVLGRPVVIKKVMLPDSLHDRQPWRRAQREL T07A9.3_Cele DSTFTIPTRYVNLSFLNAGAQGTVVMADDLVTTQRVAIKKMQQP--FVMTMSAKRAYREF Y51B9A.9_Cele EVLFIVPNRYVDLLPSQFG-NAMEVIAFDQISERRVVIKKVVLPENFDNWQHWRRAQREL ZC416.4_Cele GITFTIPTRYVNLKFLNVGAQGIVVMADDLVTTQRVAIKKMQQP--FLLTMSARRAYREF JNK_Spur DTHFQILKRYKNLKSVGSGAQGLVVAAYDVLTNQSVAIKKLSRP--FQNVTHAKRAYREY AqueK127_Aque DTLFTIPRRYQDLKPLGHGAQGVVCSAKDSVRGERIAIKKLVKP--FQNETYAKRAFREL : : ** :: . : * * : :.:**: * : :** ** JNK3_Hsap VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYL JNK2_Hsap VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH---MELDHERMSYL JNK1_Hsap VLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ---MELDHERMSYL bsk_Dmel KLMKLVNHKNIIGLLNAFTPQRNLEEFQDVYLVMELMDANLCQVIQ---MDLDHDRMSYL JNK3_Mmus VLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQ---MELDHERMSYL JNK2_Mmus VLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIH---MELDHERMSYL JNK1_Mmus VLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQ---MELDHERMSYL jnk-1_Cele KLMSLVNHKNIIGILNCFTPQKKLDEFNDLYIVMELMDANLCQVIQ---MDLDHERLSYL C49C3.10_Cele NCMLNIEDDNVVKMYSTFTPAENPLKMTEFYIVREYMHGTMKNLSASTFNEGGHRTVKSI T07A9.3_Cele ILLTTIKHPNIIRLLNAFTPDTSLSTFREVYLVMELMTHNLHEVIH--RLRLDHKTLSFF Y51B9A.9_Cele FCTLHIQEENFVKMYSIYTWVETVEEMREFYTVREYMDWNLRNFILSTPEKLDHKVIKSI ZC416.4_Cele ILLTTLKHPNIIRLLNAFTPDTSLSSFQEVYLVMEFMTHNLHEVIH--RLRLDHETLSFL JNK_Spur ILMKLCNHKNIIGLLNVFTPQRTFDDFADIYLVMELMDASLVQVVQ---MDLDHERISYL AqueK127_Aque KLMKMVNHKNVIGLLNLFSPAHSIEDFEDVYIVMELMDANLCRVIG---IELDHDRMSYL :. *.: : . :: . : :.* * * * .: .. .* :. : JNK3_Hsap LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--GTSFMMTPYVVTR JNK2_Hsap LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--CTNFMMTPYVVTR JNK1_Hsap LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--GTSFMMTPYVVTR bsk_Dmel LYQMLCGIKHLHSAGIIHRDLKPSNIVVKADCTLKILDFGLARTA--GTTFMMTPYVVTR JNK3_Mmus LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--GTSFMMTPYVVTR JNK2_Mmus LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--CTNFMMTPYVVTR JNK1_Mmus LYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTA--GTSFMMTPYVVTR jnk-1_Cele LYQMLCGIRHLHSAGIIHRDLKPSNIVVRSDCTLKILDFGLARTA--IEAFMMTPYVVTR C49C3.10_Cele FFDICRGVQYLHAMRISHRDLKPENILMNQEGDVKLCDFGHSNKE--D-PTSNTPYIVQR T07A9.3_Cele VYQSLCAIKHLHNSGVIHRDLKPSNIVVNDRCVLKVLDFGLARKKNVDTSMRMSDYVVTR Y51B9A.9_Cele FFDVCLAVQYMHSIRVGHRDLKPENVLINYEAIAKISGFAHANRE--D-PFVNTPYIVQR ZC416.4_Cele VYQSLCAIKHLHNLGFIHRDLKPSNIVVNERCVLKVLDFGLARRR--NVDMRMSDYVGTR JNK_Spur LYQMLCGIKHLHSAGIIHRDLKPSNIVVKTDCSLKILDFGLARTA--STSFMMTPYVVTR AqueK127_Aque LYQLLCGIKHLHSAGIIHRDLKPSNIVVKEDCSLKILDFGLARAA--DKAFMMTPYVVTR .:: .::::* . ******.*:::. *: .*. :. : *: * JNK3_Hsap YYRAPEVILGM--GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE JNK2_Hsap YYRAPEVILGM--GYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE JNK1_Hsap YYRAPEVILGM--GYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPE bsk_Dmel YYRAPEVILGM--GYTENVDIWSVGCIMGEMIRGGVLFPGTDHIDQWNKIIEQLGTPSPS JNK3_Mmus YYRAPEVILGM--GYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPE JNK2_Mmus YYRAPEVILGM--GYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAE JNK1_Mmus YYRAPEVILGM--GYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPE jnk-1_Cele YYRAPEVILGM--GYKENVDVWSIGCIFGELIRGRVLFPGGDHIDQWTRIIEQLGTPDRS C49C3.10_Cele FYRAPEIICETTDNNKTNVDIWSLGCILAELLTGHVLFRGKDHIDQFILMVQFLGNAGPS T07A9.3_Cele YYRAPEVILGL--PYSEKVDIWSVGCIFAEMINHTVLFPGKDRIDQWTKIYSVLGTPDDH Y51B9A.9_Cele FYRAPEILCETMDNNKPSVDIWSLGCILAELLTGKILFTGQTQIDQFFQIVRFLGNPDLS ZC416.4_Cele YYRAPEVILGL--NYSEKVDIWSVGCILAEMINHTVLFPGKDIRDQWTQISSVLRTPDDH JNK_Spur YYRAPEVILGM--GYKENVDIWSIGCIFGEMIRGQVMFPGSDHIDQWNKIADLLGTPTDI AqueK127_Aque YYRAPEVIVGM--KYKENVDIWSVGCIFAEIVRGDILLPGRDYIDQWNKVTQILGTPPQE :*****:: . .**:**:***:.*:: ::: * **: : * .. JNK3_Hsap FMKKLQPTVRNYVE--NRPK--YA-GLTFPKLFPDSLFPA-DSE--HNKLKASQARDLLS JNK2_Hsap FMKKLQPTVRNYVE--NRPK--YP-GIKFEELFPDWIFPS-ESE--RDKIKTSQARDLLS JNK1_Hsap FMKKLQPTVRTYVE--NRPK--YA-GYSFEKLFPDVLFPA-DSE--HNKLKASQARDLLS bsk_Dmel FMQRLQPTVRNYVE--NRPR--YT-GYSFDRLFPDGLFPN-DNN-QNSRRKASDARNLLS JNK3_Mmus FMKKLQPTVRNYVE--NRPK--YA-GLTFPKLFPDSLFPA-DSE--HNKLKASQARDLLS JNK2_Mmus FMKKLQPTVRNYVE--NRPK--YP-GIKFEELFPDWIFPS-ESE--RDKIKTSQARDLLS JNK1_Mmus FMKKLQPTVRTYVE--NRPK--YA-GYSFEKLFPDVLFPA-DSE--HNKLKASQARDLLS jnk-1_Cele FLERLQPTVRNYVE--NRPR--YQ-ATPFEVLFSDNMFPM-TAD--SSRLTGAQARDLLS C49C3.10_Cele FYSQMNEHARNFLLRYNLDQ--YQAPINFYSRFPDTVFQG-VLQ--FEPKECDMSRDLLF T07A9.3_Cele FISQLGQSAAMYVR--SLPR--HQ-ARAFSEIVPDTNFLP-ETENPRVHLTPHVARDLLF Y51B9A.9_Cele FYMQMPDSARTFFL--GLPMNQYQKPTNIHEHFPNSLFLD-TMI--SEPIDCDLARDLLF ZC416.4_Cele FINQLEPIGAVYVR--SLPQ--HL-ARAFNEIVPDSNFLP-ETENPKDHLTLHMARDLLF JNK_Spur FLSRLQPMVKQYVE--NRTK--CP-GYSFEMLFPDELFYQAESSTEKTKLCVAQARNLLS AqueK127_Aque FFKQLQPSVRMYCE--SQPR--HK-GKSWNELFPDDVFPN-DSK--EDAHKTRLAVDLLT * :: : . ..: * : :** JNK3_Hsap KMLVIDPAKRISVDDALQHPYIN-VWYDPA----EVEAPPPQ-IYDKQLD---------- JNK2_Hsap KMLVIDPDKRISVDEALRHPYIT-VWYDPA----EAEAPPPQ-IYDAQLE---------- JNK1_Hsap KMLVIDASKRISVDEALQHPYIN-VWYDPS----EAEAPPPK-IPDKQLD---------- bsk_Dmel KMLVIDPEQRISVDEALKHEYIN-VWYDAE----EVDAPAPE-PYDHSVD---------- JNK3_Mmus KMLVIDPAKRISVDDALQHPYIN-VWYDPA----EVEAPPPQ-IYDKQLD---------- JNK2_Mmus KMLVIDPDKRISVDEALRHPYIT-VWYDPA----EAEAPPPQ-IYDAQLE---------- JNK1_Mmus KMLVIDASKRISVDEALQHPYIN-VWYDPS----EAEAPPPK-IPDKQLD---------- jnk-1_Cele RMLVIDPERRISVDDALRHPYVN-VWFDEI----EVYAPPPL-PYDHNMD---------- C49C3.10_Cele RMLVINPDDRLNIQMVLSHPYLREIWGEIV---AEDVIPEPQ-PPNELLRF--------- T07A9.3_Cele NMLKINPEERYSVEDALNHPYVK-LWFKDD----EVNAPASENRYDQEI----------- Y51B9A.9_Cele RMLVINPDDRIDIQKILVHPYLEEVWSNIVIDNKIEEKYPPI-ALRRF------------ ZC416.4_Cele NMLKINPEERYSVEDALNHPYTM-----DD----EVNAPASE-IPDDEVN---------- JNK_Spur KMLIVDPEQRISVDEALQHPYIN-VWFDPG----EVYGPPPI-PYDHSIDDGGDHILEEW AqueK127_Aque KMLQIEPTRRVTVDEALKHPYVS-IWYDPS----EADAPPPP-KYDHCLD---------- .** ::. * :: * * * . JNK3_Hsap -------------ERE-HTIEEWKELIYKEVMNS-----------EEKTKNGV------- JNK2_Hsap -------------ERE-HAIEEWKELIYKEVMDW-----------EERSKNGV------- JNK1_Hsap -------------ERE-HTIEEWKELIYKEVMDL-----------EERTKNGV------- bsk_Dmel -------------ERE-HTVEQWKELIYEEVMDY-----------EAHNTNN-------- JNK3_Mmus -------------ERE-HTIEEWKELIYKEVMNS-----------EEKTKNGV------- JNK2_Mmus -------------ERE-HAIEEWKELIYKEVMDW-----------EERSKNGV------- JNK1_Mmus -------------ERE-HTIEEWKELIYKEVMDL-----------EERTKNGV------- jnk-1_Cele -------------V-E-QNVDSWREHIFRELTDY-----------ARTH----------- C49C3.10_Cele -----------FDFQPYSSPLDMREEIFQKIKNF-----------GNQYN---------- T07A9.3_Cele ------------DFAD-KTLIEWKELIFNEVQRY-----------QADHD---------- Y51B9A.9_Cele -----------FEFQAFSPPRQMKDEIFSTLTEF-----------GQQYN---------- ZC416.4_Cele ------------DIDD-WTLIEWKRLIFNEVQGY-----------QTDHD---------- JNK_Spur KDGTSHPIEEEKDERE-HTLEQWKDEREHTLEQWKGKLHYSYSESREHFDMFMLVFQAFE AqueK127_Aque -------------EKN-IPLAQWKKLIYEEVISF-----------DERR----------- . : : JNK3_Hsap -----------VKGQPSPSGAAV-NSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASA JNK2_Hsap -----------VKDQPSD--AAV-SSNATPSQSSSINDISSMSTEQTLASDTDSSLDAST JNK1_Hsap -----------IRGQPSPLGAAVINGSQHPSSSSSVNDVSSMSTDPTLASDTDSSLEAAA bsk_Dmel ------------------------------------------------------------ JNK3_Mmus -----------VKGQPSPSGAAV-NSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASA JNK2_Mmus ------------KDQPSD--AAV-SSKATPSQSSSINDISSMSTEHTLASDTDSSLDAST JNK1_Mmus -----------IRGQPSPLA---------------------------------------- jnk-1_Cele ------------------------------------------------------------ C49C3.10_Cele --------------------------------------I---------M----------- T07A9.3_Cele ------------------------------------------------------------ Y51B9A.9_Cele --------------------------------------I---------F----------- ZC416.4_Cele ------------------------------------------------------------ JNK_Spur HNSSYWIIILAIANTPKWSGVV-RLFN---VILSHLQDLHASSVRCMDVARTHFMYYACA AqueK127_Aque ------------------------------------------------------------ JNK3_Hsap -GPLGCCR JNK2_Hsap -GPLEGCR JNK1_Hsap -GPLGCCR bsk_Dmel -----RTR JNK3_Mmus -GPLGCCR JNK2_Mmus -GPLEGCR JNK1_Mmus ----QVQQ jnk-1_Cele ----DIYS C49C3.10_Cele ---NESKN T07A9.3_Cele ----IFTG Y51B9A.9_Cele ---NNSRN ZC416.4_Cele ----IFNE JNK_Spur IYVSESLF AqueK127_Aque ----DAKR