CLUSTAL W (1.83) multiple sequence alignment KSR2_Hsap MDEENMTKSEEQ-----------------QPLSLQKAL-QQCELVQNMIDLSISNLEGLR KSR1_Hsap MDRAALRAAAMGEKKEGGGGGDAAAAEGGAGAAASRAL-QQCGQLQKLIDISIGSLRGLR ksr-1_Cele MMQTQVASRAGY---------------SNLP----Q--F-GAGIAQDIKTQAINNLKECL KSR1_Spur LLMEKVQ----------------------------------------------------- KSR2_Spur MQPKEHIALIM--------------EQLQK------------------------------ KSR1_Mmus MDRAALRAAAMGEKKEGGGGG--AAADGGAGAAVSRAL-QQCGQLQKLIDISIGSLRGLR KSR2_Mmus MDEENMTKSEEQ-----------------QPLSLQKAL-QQCELVQNMIDLSISNLEGLR ksr_Dmel MSSNNNAPASAPDT----GST-----NANDPISGSLSVDSNLVIIQDMIDLSANHLEGLR AqueK675_Aque MSTRRDILSL-------------------------------------------------- AqueK676_Aque MSATTATAVYSSSI----GQ---TQDDKKDLFSVTK--G-KMKVQQRMIDLTARELESTR : KSR2_Hsap TKCA-----TSNDLT---QKEIRTLESKLVKYFSRQLSCKKKVALQE------------- KSR1_Hsap TKCA-----VSNDLT---QQEIRTLEAKLVRYICKQRQCKLSVAPGE------------- ksr-1_Cele KLTT-----INRFLTSSYEEDAKSVERKIFSAVY---QMTK-IGLID------------- KSR1_Spur ------------------------------------------------------------ KSR2_Spur ------------------------------------------------------------ KSR1_Mmus TKCS-----VSNDLT---QQEIRTLEAKLVKYICKQQQSKLSVTPSD------------- KSR2_Mmus TKCA-----ASNDLT---QKEIRTLESKLVKYFSRQLSCKKKVALQE------------- ksr_Dmel TQCA-----ISSTLT---QQEIRCLESKLVRYFSELLLAKMR--LNE------------- AqueK675_Aque --------------------------------LH---HQQK------------------- AqueK676_Aque VSSQSIPSDGSSDAL---KENIVLVENKLMKLFSRQLMHKH-ICLKELINAGGVSHFDFE KSR2_Hsap -RNAEL-----DGFPQLRHWFRIVDVRKEVLEEIS--PGQLSLEDLLEMTDEQVCETVEK KSR1_Hsap -RTPEL-----NSYPRFSDWLYTFNVRPEVVQEI---PRDLTLDALLEMNEAKVKETLRR ksr-1_Cele REKREI-----NA-----IWFTFVGLSAQNIRHLEI-CSITDFNALFSITNQELRSLADR KSR1_Spur -----------------------------------------NLSHLIKHGESEIRTIMKI KSR2_Spur ------------------------------------------------------------ KSR1_Mmus -RTAEL-----NSYPRFSDWLYIFNVRPEVVQEI---PQELTLDALLEMDEAKAKEMLRR KSR2_Mmus -RNAEL-----DGFPQLRHWFRIVDVRKEVLEEIS--PDQLSLEDLLEMTDEQVCETVEK ksr_Dmel -RIPANGLVPHTTGNELRQWLRVVGLSQGTLTACL--ARLTTLEQSLRLSDEEIRQLLAD AqueK675_Aque ------------------------------------------------------------ AqueK676_Aque QTNDEL-----DSLISFKMFLTVTGLEELSVKSLSSEKEKLSVDRLFQMTPQELQYLFSR KSR2_Hsap YGAN--REECARLNASLSCLRNVHMS--GGNLS-KQ-DWTIQWPTTETG----------- KSR1_Hsap CGAS--GDECGRLQYALTCLRKVTGL--GGEH--KE-D--SSWSSLDARRESGSGPSTDT ksr-1_Cele GRLD--VETKRKLLQSTVILQNHWNA---------------------------------- KSR1_Spur CGCE--EKEITRLLDAVKNLKKTFNA--NYP--SKDRSLEDGAKSPDAV---SMGNSIET KSR2_Spur ------------------------------------------------------------ KSR1_Mmus WGAS--TEECSRLQQALTCLRKVTGL--GGEH--KM-D--SGWSSTDARDS-SLGPPMDM KSR2_Mmus YGAN--QEECARLNASLSCLRNVHKS--GGNLS-KQ-DWIIQWPTTEPG----------- ksr_Dmel SPSQREEEELRRLTRAMQNLRKCMESLESGTAASNNDPEQWHWDSWDRPTHIHRGSV--G AqueK675_Aque ------------------------------------------------------------ AqueK676_Aque LEIT--ARDCHKLVSLLDLMSLYYEKWE---KG--EN---PPPGLYDVRRNSSSGR-LNS KSR2_Hsap ----------KENNPVCPPEPTPWIRT-HLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVD KSR1_Hsap L---------SAASLPWPPGSSQLGRAGNSAQGPRS------------------------ ksr-1_Cele ---YHSR---T----------S----SG-STDEPSG------------------------ KSR1_Spur V----------------------IDLSRSRSNSPS------------------------- KSR2_Spur ------------------------------------------------------------ KSR1_Mmus L--------------------SSLGRAGASTQGPRS------------------------ KSR2_Mmus ----------QESNPVCPPEPSPWIRT-HLSQSPRVQTKCPQHFCPTSPTPGTPVYTQVD ksr_Dmel N----------------------IGLGNNSTASPRTHHRQ--HGVK-----GKN-----S AqueK675_Aque ----------T---------------RGTDQSSPVN------------------------ AqueK676_Aque LTSLESRKDSTSSHTISPPAGN----HGSRSSTPLT------------------------ KSR2_Hsap RLTVDAYPGLCPP-P--PLESGHRSLPPSPRQRHAVRTPPRTPN---------------- KSR1_Hsap -ISVSALPASDSPTP--SFSEGL-SDTCIPLHA-SGRLTPRAL----------------- ksr-1_Cele ----QSTPAIVTPSP--KF-----NVPSLSV-T-SA----------------------KM KSR1_Spur ---VSSSP--EQKRP--S-IDSL-SSDLS-EVP-SVPITPPPFN-------------NKI KSR2_Spur ------------------------------------------------------------ KSR1_Mmus -ISVSALPASDSPVP--GLSEGL-SDSCIPLHT-SGRLTPRAL----------------- KSR2_Mmus RLTVDAYPNLCPPPP--PLESGHRSLPPSPRQRHVVRTPPRTPN---------------- ksr_Dmel ALANSTNFKSGRQSP--SATEEL-NSTQG-SQL-TLTLTPSPPN-------------S-- AqueK675_Aque ----VAVPSITVSSP--RS-----------R-S-NS----------------------RN AqueK676_Aque ----PLTPSST-QSPFQGLVHQN-STPSIPTHS-VPYDNIRSTSSCGCGGHALSESSGQH KSR2_Hsap -------------------------------IVT-T-VTPP--------GTPPMRKKNKL KSR1_Hsap --------------------------------HS-F-ITPP--------TTPQLRRHTKL ksr-1_Cele IQS---------------------------SSMG-F-ATTP--------KSP-------- KSR1_Spur --F---------------------------KLPP-M-PTPP--------HTPTFNKRVK- KSR2_Spur ------------------------------------------------------------ KSR1_Mmus --------------------------------HS-F-ITPP--------TTPQLRRHAKL KSR2_Mmus -------------------------------IVT-T-VTPP--------GTPPMRRKNKL ksr_Dmel -----------------------------------P-FTPSSGLSSSLNGTPQ---RSR- AqueK675_Aque AVI---------------------------GGNG-Y-PQPP--------ASP-------- AqueK676_Aque LSSSMSSLGSDLGLHVAHSNETTHLPTASNQSHDVYQTTPP--------APPTYSSSLRA KSR2_Hsap K----PP--GTPPPSSRKLIHLIPG--------------------FTALHRSKSH-EFQL KSR1_Hsap K----PP--RTPPPPSRKVFQLLPS--------------------FPTLTRSKSH-ESQL ksr-1_Cele ------------------------------------------------------------ KSR1_Spur ---------GKTPPLTRKTNLPLPA--------------------QSNWNSD-NHLNKRS KSR2_Spur ------------------------------------------------------------ KSR1_Mmus K----PP--RTPPPPSRKVFQLLPS--------------------FPTLTRSKSH-ESQL KSR2_Mmus K----PP--GTPPPSSRKLIHLIPG--------------------FTALHRSKSH-EFQL ksr_Dmel ---------G-TPPPARKHQTLLSQ----------------------------SH-VQ-- AqueK675_Aque ------------------------------------------------------------ AqueK676_Aque KKKIGHTRSHSNPPLAN---LIMPEAVPENSVPEYRSPSPPYYNGHAPPTRTGSH-PSII KSR2_Hsap GHRVDEAHTPKA-KK--KSKPL--------------------------NLKIHSSVGSCE KSR1_Hsap GNRIDDVSS--------------------------------------------------- ksr-1_Cele ------------------------------------------------------------ KSR1_Spur GPGYDSATLGRI-QV--RSRDQ--------------------------HTRRYSDDQSVM KSR2_Spur ------------------------------------------------------------ KSR1_Mmus GNRIDDVTP--------------------------------------------------- KSR2_Mmus GNRVDEANTPKA-KK--KSKPL--------------------------NLKIHSGVGSCE ksr_Dmel ---VDGEQLARN-RL--PTD---------------------------------------- AqueK675_Aque ------------------------------------------------------------ AqueK676_Aque HNSIANSNQSLANSTSTKSHPQVRRLMAGNYNFSRSISTDLGDVQPDPPLRSNSEASSVQ KSR2_Hsap N--------------------IPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVH-TEANF KSR1_Hsap ------------------------------------------------------------ ksr-1_Cele ------------------------------------------------------------ KSR1_Spur ------------------------RLSSPCRSEERLTDIGVP--------PK-------- KSR2_Spur ------------------------------------------------------------ KSR1_Mmus ------------------------------------------------------------ KSR2_Mmus N--------------------IPAQQRSPLLSERSLRSFFVGHGPFLPSTPPVH-TEANF ksr_Dmel --------------------------PSPDSHSSTSSDIFVD--------PNTNASSGGS AqueK675_Aque ------------------------------------------------------------ AqueK676_Aque SASPRQRRLSKEVGTSTSMVDLPLIQCSVEQSEFPSSSVKSHSVPRLAN-LTINTTTG-- KSR2_Hsap SANTLSVPRWSPQIPR-----RDLGNSIKHRFSTK---YWM-SQTCTVCGKGML----F- KSR1_Hsap --MRFDLSHGSPQMVR-----RDIGLSVTHRFSTK---SWL-SQVCHVCQKSMI----F- ksr-1_Cele ------------KTSS-----R-LVHAIPHKWHRSTKFRFSGDAVCHFCQRPLGFGFLNA KSR1_Spur -QGKL-VPPKSPRATH----RSNMIHAIKHRFSKK---TSMKPQSCDYCHEKIVI---LQ KSR2_Spur ----------------------TLLLRAKHCYTRQ---LVSPAKRCDFCKKSMFV----M KSR1_Mmus --MKFELPHGSPQLVR-----RDIGLSVTHRFSTK---SWL-SQVCNVCQKSMI----F- KSR2_Mmus SANTLSVPRWSPQIPR-----RDLGNSIKHRFSTK---YWM-SQTCTVCGKGML----F- ksr_Dmel SSNVL-MVPCSPGVGH-----VGMGHAIKHRFTKA---LGF-MATCTLCQKQVF----HR AqueK675_Aque -----------------------LLHWSTG------------------------------ AqueK676_Aque DHNSTSVP-TSPRIPTNYNPTGVMGHKIDHRFINH---IFFGVQECDYCKKSMVV----S : KSR2_Hsap GLKCKNCKLKCHNKCTKEA---PPCHLLIIHRGDPARLVRT------------------- KSR1_Hsap GVKCKHCRLKCHNKCTKEA---PACRISFLP---LTRLRRT------------------- ksr-1_Cele WEKCRSCKWKVHTQCKGRV--GDSCGLTPDHL-RFLF-D------------------KLI KSR1_Spur RYKCKDCKYICHSNCKFHAEKVPSCGLPRKYE-EIFRETIN------------------- KSR2_Spur TLRCKDCRVRCHRRCAQQA--ANLCELAAKHNLTTGPESRNVVPTCHAALAEASRRHQSA KSR1_Mmus GVKCKHCRLKCHNKCTKEA---PACRITFLP---LARLRRT------------------- KSR2_Mmus GLKCKNCKLKCHNKCTKEA---PPCHLLIIHRGDPARLVRT------------------- ksr_Dmel WMKCTDCKYICHKSCAPHV--PPSCGLPREYV-DEFRHIKE------------------- AqueK675_Aque ------------------------------------------------------------ AqueK676_Aque GYRCRYCKSKFHKNCSKLA--PPICGLPKYFL-NYARQHFMMSP-SHESVYQVNKTGHLT KSR2_Hsap ---ESVPCDINNPLRKPPR---------YSDLHISQTL-PKT---------NKINKD--- KSR1_Hsap ---ESVPSDINNPVDR------------AAEPHF-GTL-PKA---------L-TKKE--- ksr-1_Cele QE-N------NGGM--------------WKDP---QSV-PGS----------R--SM--- KSR1_Spur ---SA-------------R---------TDPPTV------------------------VN KSR2_Spur NS-TPVPTHRRKSSTESFRE---------IETHQ-STFSVRRSTTRQRLSTTTVPKD--- KSR1_Mmus ---ESVPSDINNPVDR------------AAEPHF-GTL-PKA---------L-TKKE--- KSR2_Mmus ---ESVPCDINNPVRKPAR---------YSDLHISQTL-PKT---------NKINKD--- ksr_Dmel ---QGG------------Y---------ASLPHVHGAA-KGS---------PLVKKSTLG AqueK675_Aque ---------------------------------------RR------------------- AqueK676_Aque SSGEYGSCNTPTPSSEQLREETFFIHDLNREPSK-NQFSPVT----------STKRP--- KSR2_Hsap HIPVPY----QPDSSSNP-S---------------------------------------- KSR1_Hsap HPPAMN----HLDSSSNP-S---------------------------------------- ksr-1_Cele NEPAFQ----FPDTAIDSSS---------------------------------------- KSR1_Spur --VASS----TGDSSSNP-S---------------------------------------- KSR2_Spur HSLGRVSRSTLSSQSSNRSSVSGYYSQESDASLLSECDTPKEI-----------SVFDSF KSR1_Mmus HPPAM-----NLDSSSNP-S---------------------------------------- KSR2_Mmus HIPVPY----QPDSSSNP-S---------------------------------------- ksr_Dmel KPLHQQ----HGDSSSPS-S---------------------------------------- AqueK675_Aque --VWS-----EPGGSSGLS----------------------------------------- AqueK676_Aque HPPAPS----SPAHDHAPFSSSHS-TSRLEVPQL--------FLPGVRSHSNYRHPHHHR KSR2_Hsap ---STTSSTPSSPAP---P--LP------PSATP--PSP-LHPSPQCTRQ-QKNFNLPAS KSR1_Hsap ---STTSSTPSSPAP---F--P-------TSSNP--SSATTPPNPSPGQR-DSRFNFPAA ksr-1_Cele ---STNSSAPSTPAL---P--AG------ISGNV--SSL-TAPY----R-SERKFLFPDT KSR1_Spur ---STTSSTPSSPAP---F--IS------TSGIPLPSPSPALPSPSPRMM-VPQFKFPPD KSR2_Spur GPGDVTSPIPSSSRSRRHEAWA---------ATK--PAP-TSTY----M-D-------CP KSR1_Mmus ---STTSSTPSSPAP---F--L-------TSSNP--SSATTPPNPSPGQR-DSRFSFPAA KSR2_Mmus ---STTSSTPSSPAP---P--LP------PSATP--PSP-LHPSPQCPRQ-KKNFNLPAS ksr_Dmel ---SCTSSTPSSPAL---F--QQRERELDQAGSS--SSANLLPTPSLGKHQPSQFNFPNV AqueK675_Aque ---ASS---------------LL------VDSGR--SSL-TS-Y----G-SQESLLFTS- AqueK676_Aque VPPHSTSSSPSTSSQ---SSPCL------TPMSP--RSP-LDPP----V-E-------YS . . KSR2_Hsap HY--YKYK-------------QQ-FIF-PD------------------------------ KSR1_Hsap YF--IHHR-------------QQ-FIF-PV-----------PSAGHCWKCL--------L ksr-1_Cele ENYSVHNR-------------LP-IL-------------VISEGDHPTTTE--------I KSR1_Spur VS--DDV--------------SE------------------------------------- KSR2_Spur ------------------------------------------------AHGNCESGAETN KSR1_Mmus YF--IHHR-------------QQ-FIF-PD------------------------------ KSR2_Mmus HY--YKYK-------------QQ-FIF-PD------------------------------ ksr_Dmel TV--TSSGGSGGVSLISNEPVPEQFPTAPATANGGLDSLVSSSNGHM-SS---------- AqueK675_Aque ------------------------------------------------------------ AqueK676_Aque GFNSL-HR-------------SI-AI-------------VLSTDDNTSSTDEEGDGP--- KSR2_Hsap -----------VVPVPETPTRA------------------------------PQVIL--- KSR1_Hsap IAESLKENAFNISAFAHA---A------------------------------P---L--- ksr-1_Cele QQETENH------NKSAAA----------------------------------------- KSR1_Spur ---FLDN---N-----------------------------------------ENV-T--- KSR2_Spur LMMSLDGG-S--LVATWPQ----------------------------------------- KSR1_Mmus -----------ISACSQA---A------------------------------P---L--- KSR2_Mmus -----------VVPVPETPTRA------------------------------PQVIL--- ksr_Dmel ---LIGS---QTSNASTAATLTG-----------------------------SLV-N--- AqueK675_Aque ------------------------------------------------------------ AqueK676_Aque DGEFYEGS-E--GFTSDSS---NSSFNEVGLVGPAHNRGLKLPSRGIAAQSLPNLLMAER KSR2_Hsap -----------------------------HPVTSNPI-----------LEG--N--PLLQ KSR1_Hsap -----------------------------PEAADGTR-----------LDD--Q--PKAD ksr-1_Cele -----------------------------S--MSGNI------------ESE-GT----- KSR1_Spur -----------------------------STSSDRT--------------------ITVD KSR2_Spur -------------------------DRKCN--C----------------------CPHI- KSR1_Mmus -----------------------------SSTADSTR-----------LDD--Q--PKTD KSR2_Mmus -----------------------------HPVTSNTI-----------LEG--N--PLLQ ksr_Dmel -----------------------------STTTTSTCSFFPRKLSTAGVDKR-TP-FTSE AqueK675_Aque ------------------------------------------------------P----- AqueK676_Aque RQSRGGGANGEGLYATSEDNLQSWYDRKPS--LSGTI---STA------DSKTSTLVGS- KSR2_Hsap I--E-VEP-TSENEEVHDEAEE-SEDDFEEMNLSLLS----AR---S-FPRKASQTSIFL KSR1_Hsap VLEA-HEAEAEEPEAGKSEAED-DEDEVDDLPSSRRP----WR---GPISRKASQTSVYL ksr-1_Cele IVAN-HED-STGSQEVDSEAAP-SQEAVDKFNKRADGGFTWERHAWNMSTIRGPNAQASW KSR1_Spur SHDT-HDP-FTDSERTLPEQVE-PVDEVSDPE---PN----------ILLATRKNSQKLL KSR2_Spur -PENNCNS-NDQMVS----------DWTEEYRR-------------S--SLHYEAQKEGL KSR1_Mmus VLGV-HEAEAEEPEAGKSEAEDDEEDEVDDLPSSRRP----WR---GPISRKASQTSVYL KSR2_Mmus I--E-VEP-TSENEESHNEAEE-SEDEFEEMNLSLLS----AR---S-FPRKASQTSIFL ksr_Dmel YTDT-HKS--NDSDKTVSLSGS-ASTDSDRTPVRVDS----TE---DGDSGQWRQNSISL AqueK675_Aque LATD-SDV-FSDCYTDDEEEEE-EEDEIEEVPL-------------SVY------LQGKW AqueK676_Aque IMEG-SDD-DDDSYA-DSEGVG-SSGGLDEPEV-------------N--KYRIRHRNSVV . . . KSR2_Hsap QEWDIPFEQLEIG---ELIGKGRFGQVYHGRWHGEVAIRLIDIERDN--EDQLKAFKREV KSR1_Hsap QEWDIPFEQVELG---EPIGQGRWGRVHRGRWHGEVAIRLLEMDGHN--QDHLKLFKKEV ksr-1_Cele NEVTIQFETIEFDKQAPIIGRGRFGKVLRGFHYGDVAVKVYTMEHISDASKKAEEFKLEV KSR1_Spur SEWDIPFEQLEIL---DLIGTGRFGAVH-------------------------------- KSR2_Spur SEWTIPHANLKYG---RCIEKGKLGSTYKGHWHGEVLIQTR---YSKS--TDINDFLDEV KSR1_Mmus QEWDIPFEQVELG---EPIGQGRWGRVHRGRWHGEVAIRLLEMDGHN--QDHLKLFKKEV KSR2_Mmus QEWDIPFEQLEIG---ELIGKGRFGQVYHGRWHGEVAIRLIDIERDN--EDQLKAFKREV ksr_Dmel KEWDIPYGDLLLL---ERIGQGRFGTVHRALWHGDVAVKLLNEDYLQD-EHMLETFRSEV AqueK675_Aque KEWMVGSEEIQLY---GEAASSCKETVQKGYWHGNVWVHQRTIK--RQ--EDVRSFANEV AqueK676_Aque DEWIIPYNDLKLL---EKLGSGPVAEVYKGYWHGEVAVKRFVLPNATP--KQINKFREEV .* : : . . KSR2_Hsap MAYRQTRHENVVLFMGACMSPP---HLAIITSLCKG-RTLYSVVRDAKIVLDVNKTRQIA KSR1_Hsap MNYRQTRHENVVLFMGACMNPP---HLAIITSFCKG-RTLHSFVRDPKTSLDINKTRQIA ksr-1_Cele SAYKNTRHDNIALFLGYFMSDG---QYGMVMSLSKGSQSLYTLLHVVREKLDLATTRKIA KSR1_Spur -------------------------------NLCKG-QTLYTHIHLRKDRFNINRTIQIA KSR2_Spur AMLSKIRHENIALFMGACVEPG---NLAVVNSIHKG-PSLYHHLHVQRRKLQTSSKMDIA KSR1_Mmus MNYRQTRHENVVLFMGACMNPP---HLAIITSFCKG-RTLHSFVRDPKTSLDINKTRQIA KSR2_Mmus MAYRQTRHENVVLFMGACMSPP---HLAIITSLCKG-RTLYSVVRDAKIVLDVNKTRQIA ksr_Dmel ANFKNTRHENLVLFMGACMNPP---YLAIVTSLCKG-NTLYTYIHQRREKFAMNRTLLIA AqueK675_Aque NTLCCIRHENIQLFMGVCLDLPAGDTFGIIMSEVKG-DTLYNHIHKLGHNFTTPSKLKIL AqueK676_Aque AVLKKIRHENLALFMGVCLTTP---NLAIITSYCKG-YTLYKLLHYWSEAFSLERLANIG . ** :*: :: : * KSR2_Hsap QEIVKGMGYLHAKGILHKDLKSKNVFYDN----GKVVIT-DFGLFSISGVLQAGR--RED KSR1_Hsap QEIIKGMGYLHAKGIVHKDLKSKNVFYDN----GKVVIT-DFGLFGISGVVREGR--REN ksr-1_Cele QQICQAVSYLHTKKILHKDLRSKNILLESK---NKVVIT-DFGILSMKRLAHPKQ-K--S KSR1_Spur TQITQGMSYLHHKGIVHKDLKSKNIFIEN----GKVVLT-DFALFSIGRLSKQKT--RKD KSR2_Spur RQIGQAMGYLQAKGIIVGHLSSRCVYLESK---VKLSVT-RVDTS---DV--TCQ--RAS KSR1_Mmus QEIIKGMGYLHAKGIVHKDLKSKNVFYDN----GKVVIT-DFGLFGISGVVREER--REN KSR2_Mmus QEIVKGMGYLHAKGILHKDLKSKNVFYDN----GKVVIT-DFGLFSISGVLQAGR--RDD ksr_Dmel QQIAQGMGYLHAREIIHKDLRTKNIFIEN----GKVIIT-DFGLFSSTKLLYC-----DM AqueK675_Aque RQISEGMEYLHAKGIQHGGLSSKLVTINH----R-VCISLSFHN------------T--N AqueK676_Aque RQIAQAMGYLHARGIIHKGLNTKNIFLEKRDQKEKVIIT-DMGLSSLSSLLYDNTTSKGG :* :.: **: : * * :: : : : :: . KSR2_Hsap KLRIQNGWLCHLAPEIIRQLSPDTE---EDKLPF--SKHSDVFALGTIWYELHAREWPFK KSR1_Hsap QLKLSHDWLCYLAPEIVREMTPGKD---EDQLPF--SKAADVYAFGTVWYELQARDWPLK ksr-1_Cele GYLTSKFWTNYIAPELAMAMRTEYDEYECDDFPF--SENSDVYAFGCVWFEMLTGALPYA KSR1_Spur SLVIPDGWLCYLAPELITSLKINTDGTQDMELPF--SEKSDVYSFGTIWYELLAGEWPFH KSR2_Spur HACLPRGKLQYLAPELLAKARVVPPE-FITGNEQ--THSTDVYAFGTILFEIIAGRWPLQ KSR1_Mmus QLKLSHDWLCYLAPEIVREMIPGRD---EDQLPF--SKAADVYAFGTVWYELQARDWPFK KSR2_Mmus KLRIQNGWLCHLAPEIIRQLSPDTE---EDKLPF--SKHSDVFALGTIWYELHAREWPFK ksr_Dmel GLGVPHNWLCYLAPELIRALQPEKPR--GECLEF--TPYSDVYSFGTVWYELICGEFTFK AqueK675_Aque NRQLEGCDLPYLTPEEIRSITQLSNGYLFLPTKP--TPSTDIFAFGTIAYELTTLKLPFL AqueK676_Aque VVTFPRAQLYSLAPEIIRKISPTPVV-QIDQEPYSYNYATDVYAFGTILYELITKRFPFS ::** . :*::::* : :*: . KSR2_Hsap TQP------AEAIIWQMGT--GMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDM KSR1_Hsap NQA------AEASIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDM ksr-1_Cele GEL------PHQILFAKTQ--GIRPVLPNVKCTQELKELLVSCWNTAPQDRPTLTDINLK KSR1_Spur KQP------VETVIWQVGK--GLKQPLNHLQASRDVKEILMMCWSYSPDSRPIFQHIKKT KSR2_Spur YAC------SESVIYQTCS--GRRDDFRNVTCSSTMKNLIQECWSQNPNERPSFQDIVKE KSR1_Mmus HQP------AEALIWQIGSGEGVRRVLASVSLGKEVGEILSACWAFDLQERPSFSLLMDM KSR2_Mmus TQP------AEAIIWQMGT--GMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDM ksr_Dmel DQP------AESIIWQVGR--GMKQSLANLQSGRDVKDLLMLCWTYEKEHRPQFARLLSL AqueK675_Aque NQS------LLDLIWSVGN--NGHQSLKLLP-RSCFRSVIHRCWSHT--RRTTFKDILSS AqueK676_Aque TDSLGFAYEFEVVIFLVGH--GHRQPFKG-ETPKKLKDIVWECWSHQPQDRPPFSDLQER :: . : : . .:: ** *. : : KSR2_Hsap LEKLPK----RNRRLSHPGHFWKSAE------------------------L KSR1_Hsap LEKLPK----LNRRLSHPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM ksr-1_Cele LTALPKKP-RVNRSPSFPVMM-KSYE----------------------STF KSR1_Spur ILRLPKKK-GLHRSPSHPLHLSRSAE----------------------SVL KSR2_Spur LKKNVSL-GNMKHSLSEPDNLNRLGTG---------------------LFR KSR1_Mmus LERLPK----LNRRLSHPGHFWKSADINSSKVMPRFERFGLGTLESGNPKM KSR2_Mmus LEKLPK----RNRRLSHPGHFWKSA-------------------------E ksr_Dmel LEHLPKK--RLARSPSHPVNLSRSAE----------------------SVF AqueK675_Aque IQDNTSFPPTRFSSTSLPLSS-QHCT----------------------LRQ AqueK676_Aque LARLCRKHTPITRSPSHPINLSKSVDN--------------------LLHI : * * :