CLUSTAL W (1.83) multiple sequence alignment LIMK1_Hsap MRLTLLCCTWREERMG---------EEGSELPVCASCGQRIY---DGQYLQALNADWHAD LIMK2_Hsap M---------------------------------------------GSYLSVPAYFTSRD LIMK1_Dmel MHHQQRLRAN-GGRGGTGLGAGSGPVSGGHSPLCAHCRGQLLPHPEEPIVMALGQQWHCD LIMK2_Mmus M---------------------------------------------GSYLSVPAYFTSRD LIMK1_Mmus MRLTLLCCTWREERMG---------EEGSELPVCASCGQRIY---DGQYLQALNADWHAD LIMK_Spur MS---------------------------------------------------------- AqueK481_Aque M----------------------------------------------------GRMWHLE * LIMK1_Hsap CFRCCDCSASLSHQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAG-ELKYHPE LIMK2_Hsap LFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMT-GPFMVAG-EFKYHPE LIMK1_Dmel CFRCSVCEGHLHNWYFEREGLLYCREDYYGRFGDACQQCMAVIT-GPVMVAG-EHKFHPE LIMK2_Mmus PFRCSECQESLTNWYYEKDGKLYCHKDYWAKFGEFCHGCSLLMT-GPAMVAG-EFKYHPE LIMK1_Mmus CFRCCECSVSLSHQYYEKDGQLFCKKDYWARYGESCHGCSEHITKGLVMVAG-ELKYHPE LIMK_Spur -----------------------CADIFFRS----------------------------- AqueK481_Aque CFRCTVCHVTLPECYYEEDGLSYCKDDFFKRLSHKCHQCSDYIT-GPTMAVGFSRMYHPE * . :: LIMK1_Hsap CFICLTCGTFIGDGDTYTLVEHSKLYCGHCYYQT-VVTPVIEQILPDSPGSHLPHTVTLV LIMK2_Hsap CFACMSCKVIIEDGDAYALVQHATLYCGKCHNEV-VLAPMFERLSTESVQEQLPYSVTLI LIMK1_Dmel CFCCTACGSFIGEGESYALVERSKLYCGQCYGKR-SCQPADAKARITTAGKP-MHSIRLV LIMK2_Mmus CFACMSCKVIIEDGDAYALVQHATLYCGKCHNEV-VLAPMFERLSTESVQDQLPYSVTLI LIMK1_Mmus CFICLACGNFIGDGDTYTLVEHSKLYCGQCYYQT-VVTPVIEQILPDSPGSHLPHTVTLV LIMK_Spur ------------------------------------------------------------ AqueK481_Aque CFHCTVCETTLGEKDIYCLLNTKDILCNDCSISDSCINGMISPVKTNSG-RTVYVSIQQI LIMK1_Hsap SI-------------PASS-HGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVD------- LIMK2_Hsap SM-------------PATT-EGRRGFSVSVESA------CSNYATTVQVKEVN------- LIMK1_Dmel EI-------------PKDATPGLRVDGVALDDG------C----PTVRITDLFCNFFLWL LIMK2_Mmus SM-------------PATT-ECRRGFSVTVESA------SSNYATTVQVKEVN------- LIMK1_Mmus SI-------------PASA-HGKRGLSVSIDPPHGPPGCGTEHSHTVRVQGVD------- LIMK_Spur ------------------------------------------------------------ AqueK481_Aque KVTLQRRVRFRLDGLPPAEG-EKKRLSIKDFTPPQLPNPNQKTSYKKKVLKIE------- LIMK1_Hsap ----------PGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLE LIMK2_Hsap ----------RMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIE LIMK1_Dmel TSMAEQCCGAPYRI-DVNLTNLHIGDRILEVNGTPVSDSSVEQIDKLIRSNEKMLQLTVE LIMK2_Mmus ----------RMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAIKQTSQTLQLLIE LIMK1_Mmus ----------PGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEIDLLIQETSRLLQLTLE LIMK_Spur ----------------------------------------------------------QS AqueK481_Aque ----------KLPRS-LIGTPLKSGDIIMEINEIPIINQNQEEINNLMEVYDDCLYLMIE . LIMK1_Hsap HDPHDTLGHGLG----------------PETSPLSSP----------AYTPSGEAGSSAR LIMK2_Hsap HDPVSQRLDQLRLEA----RLAPHMQNAGHPHALS-T----------LDTKENLEGT-LR LIMK1_Dmel HDPVQVCRSCSQAD------IQRAMSASTLILPLSTSASSVEVGRERLYKTPGEQGTKAR LIMK2_Mmus HDPVPQRLDQLRLDA----RLPPHMQSTGHTLMLS-T----------LDTKENQEGT-LR LIMK1_Mmus HDPHDSLGHGPV----------------SDPSPLSSP----------VHTPSGQAASSAR LIMK_Spur HDP----------------------------STGSKV----------MHASSCNWGERRN AqueK481_Aque RNSNQSHDKGSSNHLVSQNSTSSELDVTSEIHSVSSPAHH--------KPPLGEAADS-N ::. * . . LIMK1_Hsap QKPVLRSC--SIDRSPGAG-SL--------------------------GSPASQRKDLGR LIMK2_Hsap RRSLRRSN--SISKSPGPS-SP--------------------------KEPLLFSRDISR LIMK1_Dmel K--LRQATNASTTIPPAAG-ATAMTQLKEKERCSSLSKLLDEQHQAQQHSAHPQLYDLSR LIMK2_Mmus RRSLRRSN--SISKSPGPS-SP--------------------------KEPLLLSRDISR LIMK1_Mmus QKPVLRSC--SIDTSPGTS-SL--------------------------ASPASQRKDLGR LIMK_Spur N-------------YPVMC-SP--------------------------T------SPLSR AqueK481_Aque TL--HV--NGSLPAVPENSQSSQTSSYKPKLRP-SLS---------SSG-LSNPDYDLDL * : :. LIMK1_Hsap SESLRVVC---------------------------------RPHRIFRPSDLIHGEVLGK LIMK2_Hsap SESLRCSS--------------------------------SYSQQIFRPCDLIHGEVLGK LIMK1_Dmel TQSCRVVQ---------------------------------KPQRIFRATDLVIGEKLGE LIMK2_Mmus SESLRCSS--------------------------------SYSQQIFRPCDLIHGEVLGK LIMK1_Mmus SESLRVVC---------------------------------RPHRIFRPSDLIHGEVLGK LIMK_Spur TQSYRVS----------------------------------KNQRIFRPADLIKGEVLGQ AqueK481_Aque TKSLNVPSNPVPVSHGTAAIPVPRLVRSRRAQSVPVIDGRAGYTSCFRLHDLIIGEVLGH ::* . ** **: ** **. LIMK1_Hsap GCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYK-D LIMK2_Hsap GFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYK-D LIMK1_Dmel GFFGKVFKVTHRQSGEVMVLKELHRADEEAQRNFIKEVAVLRLLDHRHVLKFIGVLYK-D LIMK2_Mmus GFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYK-D LIMK1_Mmus GCFGQAIKVTHRETGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYK-D LIMK_Spur GFFGKAVKVTHRYTGEVMVIKELVRYSDSAQRDFLKEVKVLRSLDHYHVLKFIGVLYR-D AqueK481_Aque GFYGNVIKVTHRYTEQVMVMKEMRNCTEEAKKTFRKEVAVLKRLHHPNLLKFIGILYQED * :*:..****: : :***:**: . :.::: * .** *:: *.* ::*****:**: * LIMK1_Hsap KRLNFITEYIKGGTLRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNC LIMK2_Hsap KKLNLLTEYIEGGTLKDFLRSMD-PFPWQQKVRFAKGIASGMAYLHSMCIIHRDLNSHNC LIMK1_Dmel KKLHMVTEYVAGGCLKELIHDPAQVLPWPQRVRLARDIACGMSYLHSMNIIHRDLNSMNC LIMK2_Mmus KKLNLLTEYIEGGTLKDFLRSVD-PFPWQQKVRFAKGISSGMAYLHSMCIIHRDLNSHNC LIMK1_Mmus KRLNFITEYIKGGTLRGIIKNMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNC LIMK_Spur KRLNLVTEFVGGGTLENIISDLDKPFPWLQRINAARDIASGMSYLHSMGIIHRDLNSNNC AqueK481_Aque KLLTLITEFIGGGTLRKRIKKKDVPFPWKLRIQIALDISAGM------------------ * * ::**:: ** *. : . ** :: * .*:.** LIMK1_Hsap LVRENKNVVVADFGLARLMVDEKTQ----------------------PEGLRSLKKPDRK LIMK2_Hsap LIKLDKTVVVADFGLSRLIVEERKR----------------APMEKATTKKRTLRKNDRK LIMK1_Dmel LVREDRSVIVADFGLARSVDAPRLPSGNMTPGGYGSGANSDAPMSPSGT-LRRSKSRQRR LIMK2_Mmus LIKLDKTVVVADFGLSRLIVEERKR----------------PPVEKATTKKRTLRKSDRK LIMK1_Mmus LVRENRNVVVADFGLARLMIDEKNQ----------------------SEDLRSLKKPDRK LIMK_Spur LVRDDGSVVVADFGLARVFIDENDSR---------------CPNSFGP-GRDKHQPAGRK AqueK481_Aque ----NSRAVVADFGLARVFYPL----------------------DFSN-D--KSKKRNNR : .:******:* . : .: LIMK1_Hsap KRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVR LIMK2_Hsap KRYTVVGNPYWMAPEMLNGKSYDETVDIFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVK LIMK1_Dmel QRYTVVGNPYWMAPEMMKGLKYDEKLDVFSFGIMLCEIIGRVEADPDFMPRNSDFSLNQQ LIMK2_Mmus KRYTVVGNPYWMAPEMLNGKSYDETVDVFSFGIVLCEIIGQVYADPDCLPRTLDFGLNVK LIMK1_Mmus KRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLCEIIGRVNADPDYLPRTMDFGLNVR LIMK_Spur KRYTMVGTAFWMAPEMLKGKDYNERVDVFSFGIVMCELIGRVSACPDDLPRSGDFGLDEV AqueK481_Aque SRMTVVGSPYWMAPEMLKGQDYDETVDIFSFGIVLCEIISRVKSDPDELPRLNSFGLDEL .* *:**..:******::* .*:* :*:*****::**:*.:* : ** :** .*.*: LIMK1_Hsap GFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFV---------------------KLEHW LIMK2_Hsap LFWEKFVPTDCPPAFFPLAAICCRLEPESRAPPGAAGEGPGCADDEGPVRRQGKVTIKYD LIMK1_Dmel EFREKFC-AQCPEPFVKVAFVCCDLNPDMRPCFE---------------------TLHVW LIMK2_Mmus LFWEKFVPTDCPPAFFPLAAICCKLEPESRPAFS---------------------KLEDS LIMK1_Mmus GFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFV---------------------KLEQW LIMK_Spur PFMAQCC-DTCPKTFHQIMLMCVRMDSDERPSFD---------------------ELDQR AqueK481_Aque KFREM--RGDCPLLFYNLAVQCTSLNPEERPLFL---------------------DIRKG * ** * : * ::.: *. : LIMK1_Hsap LETLRMHLAG-HLPLGPQL----------------------------------------- LIMK2_Hsap PKELRKHL-NLEEWILEQLT---------------------------------------- LIMK1_Dmel LQRLADDLAADRVPPERLLHEIETFQEWYASSEDALSPTSQRSLNNLDELVKSAVDSEIS LIMK2_Mmus FEALSLFLGELAIPLPAEL----------------------------------------- LIMK1_Mmus LETLRMHLSG-HLPLGPQL----------------------------------------- LIMK_Spur LSSFSLHFER-LSPRAKDL----------------------------------------- AqueK481_Aque LSHYINLIES-NSPLPDNL----------------------------------------- . : * LIMK1_Hsap ------------------------------------------------------------ LIMK2_Hsap -------------------------------RLYD------------------------- LIMK1_Dmel PVEKEKENMVIKPQDIPKSPHLGKDFSPSGERLRDSMRARRRQRFLGAQEERRNLTPDTE LIMK2_Mmus ------------------------------------------------------------ LIMK1_Mmus ------------------------------------------------------------ LIMK_Spur ------------------------------------------------------------ AqueK481_Aque ------------------------------------------------------------ LIMK1_Hsap ------------------------------------------------------------ LIMK2_Hsap ------------------------------------------------------------ LIMK1_Dmel SKERALKKALKKCRPFGERGYLVDLRAGAELQLEDVRDLNTYSDVDSSCDTSLNYHDVNN LIMK2_Mmus ------------------------------------------------------------ LIMK1_Mmus ------------------------------------------------------------ LIMK_Spur ------------------------------------------------------------ AqueK481_Aque ------------------------------------------------------------ LIMK1_Hsap ------------------------------------------------------------ LIMK2_Hsap ---------------------------CQEEEISELEID--------------------- LIMK1_Dmel LPAAQEDENTVKPGKEELLEESTNKPSNQESQHHRLAIDDMRTRLNQCRSKFEHLEEASR LIMK2_Mmus ------------------------------------------------------------ LIMK1_Mmus ------------------------------------------------------------ LIMK_Spur ------------------------------------------------------------ AqueK481_Aque ------------------------------------------------------------ LIMK1_Hsap ------------------------------------------------------------ LIMK2_Hsap --------------------------V--------------------------------- LIMK1_Dmel RNFNQSQHSMKNFFKTPPVALKMFQRLEHEAAALNGGNNCPPPPPRTQRINQTPIFGRKN LIMK2_Mmus ------------------------------------------------------------ LIMK1_Mmus ------------------------------------------------------------ LIMK_Spur ------------------------------------------------------------ AqueK481_Aque ------------------------------------------------------------ LIMK1_Hsap ------------------------------------------------------------ LIMK2_Hsap -------------DELLDMESDD------------------------------------- LIMK1_Dmel PPVAIVGQKLQHAESLEDLASSGVAKQLATPAPKRSKATATTKGGQSSNPPLFLPPSLNI LIMK2_Mmus ------------------------------------------------------------ LIMK1_Mmus ------------------------------------------------------------ LIMK_Spur ------------------------------------------------------------ AqueK481_Aque ------------------------------------------------------------ LIMK1_Hsap -------------------------------EQL-------------------------- LIMK2_Hsap -------------------------AWASRVKEL-------------------------- LIMK1_Dmel SVALNSNGNVTTTTNTNSSCPPSASDWLPKKHKLTLPLPSAQQQRTSSNHRLPMCNNKGK LIMK2_Mmus -------------------------------EDL-------------------------- LIMK1_Mmus -------------------------------EQL-------------------------- LIMK_Spur -------------------------------ESY-------------------------- AqueK481_Aque -------------------------------YDL-------------------------- . LIMK1_Hsap ------------------------------D-------R--------------------- LIMK2_Hsap ---------------LVDCYKPTEAFISGLL-------D--------------------- LIMK1_Dmel TLKPLPSRTGSQGIPASNCVSPTRSSRPGSPTKHLAQRHTAATAQRLTNAAATHQQQHQQ LIMK2_Mmus ------------------------------D-------H--------------------- LIMK1_Mmus ------------------------------E-------R--------------------- LIMK_Spur ------------------------------H----------------------------- AqueK481_Aque ------------------------------L-------D--------------------- LIMK1_Hsap ------------------------------------------------------------ LIMK2_Hsap ------------------------------------------------------------ LIMK1_Dmel QSSKTTRLNILSPEKVHRLGARLTDQKQKMREEAAATASSVGGAGCAAGTAAGSLNGHRT LIMK2_Mmus ------------------------------------------------------------ LIMK1_Mmus ------------------------------------------------------------ LIMK_Spur ------------------------------------------------------------ AqueK481_Aque ------------------------------------------------------------ LIMK1_Hsap ---------GFWETYRRGESGLP--AHPEVPD LIMK2_Hsap ---------KIRA-----MQKL----STPQKK LIMK1_Dmel IGSSGTPNSAVGERRRRAAPSPPVRTHFNTRC LIMK2_Mmus ---------TVSM-----EYGL----TRDSPP LIMK1_Mmus ---------GFWETYRRGESSLP--AHPEVPD LIMK_Spur -------------------ISPT--EDPPPKT AqueK481_Aque --------------------DHN--QHELDTV