CLUSTAL W (1.83) multiple sequence alignment mek-2_Cele MSS---------GKRRNPLGLSLPPTVNEQ------------------------------ Dsor1_Dmel MSKN-------K-LNLVLPPVNTEATVAAA-----TV----------------------- MAP2K1_Mmus MPK----------KKPT--PIQLNPAP-DG------------------------------ MAP2K2_Mmus MLA---------RRKPVLPALTINPTIAEG------------------------------ MAP2K1_Hsap MPK----------KKPT--PIQLNPAP-DG------------------------------ MAP2K2_Hsap MLA---------RRKPVLPALTINPTIAEG------------------------------ MEK_Spur MSKT-------PGKNKNLLNLTIMPIQSES------------------------------ CC1G_02205_Ccin MTDLFVQASGPLRTKRNFKGLALSAEPPSPPPPG-------------------GKKRPPP CC1G_03368_Ccin MATP-------IRKKRNFKALQLNVGDPQPASPSSTEPDPISIRTAPTAVGPRLKKKPPP AqueK243_Aque MAEK--------RKKPKPSPLSLQSSVETL------------------------------ GK083_Glam MK-----------RRP--MALTLDASTASA------------------------------ * . : mek-2_Cele --------------S-------------------------E-SGEATA-EEATATVPL-E Dsor1_Dmel ------------A-PT----PP----------FKTPSGTDTHSLLGKP-K--TSIDAL-T MAP2K1_Mmus --------------S------------------------AV-NGTSSA-E--TNLEAL-Q MAP2K2_Mmus --------------P------------------------SP-TSEGAS-E--ANLVDL-Q MAP2K1_Hsap --------------S------------------------AV-NGTSSA-E--TNLEAL-Q MAP2K2_Hsap --------------P------------------------SP-TSEGAS-E--ANLVDL-Q MEK_Spur --------------NG----GG----------QKAQSATTA-TEKSTS-G--IKVDAL-T CC1G_02205_Ccin LGAAMALGG---G-PA----PL----GGLPLLDDLPGESPA-TG-----RHSAMQATL-S CC1G_03368_Ccin MTLAAPKINSVGNVVASVDPPEDSGSGNFLVVSNGPNSAPL-TGTNINVRRNTLHATL-S AqueK243_Aque --------------D------------------------SP-D--GSI-P--DKVPDPSK GK083_Glam --------------DG---------------------GVED-VQKGGS-G--TQYIKI-T mek-2_Cele EQLKKLGLTEPQTQRL--SEFLQVKEG---IKELSEDMLQTEGELGHGNGGVVNKCVHRK Dsor1_Dmel ETLEGLDMGDTERKRI--KMFLSQKEK---IGELSDEDLEKLGELGSGNGGVVMKVRHTH MAP2K1_Mmus KKLEELELDEQQRKRL--EAFLTQKQK---VGELKDDDFEKISELGAGNGGVVFKVSHKP MAP2K2_Mmus KKLEELDLDEQQRKRL--EAFLTQKAK---VGELKDDDFERISELGAGNGGVVTKARHRP MAP2K1_Hsap KKLEELELDEQQRKRL--EAFLTQKQK---VGELKDDDFEKISELGAGNGGVVFKVSHKP MAP2K2_Hsap KKLEELELDEQQKKRL--EAFLTQKAK---VGELKDDDFERISELGAGNGGVVTKVQHRP MEK_Spur KKLDNLDLDEPQRKRL--EEFMVDKRKIMEIGEFCNDDFEVLKELGAGNGGVVTKVKHKM CC1G_02205_Ccin DKLAKLEL----------------KKR---IKDLKNDDLKKLSDLGQGNGGSVEKVEHLP CC1G_03368_Ccin TTLANLDM---------------NKET---KLELRNEDLVDIHDLGQGNGGSVKKVEHTP AqueK243_Aque PSAAPEPMTEQQALQM--KTFLGQKEEFLTHGELKDNQFERLSELGHGNGGVVLKVMHKP GK083_Glam DSGSLNTLHESLQISAHGITKTSSPEH---ILNVQESDLEVVKPLGAGAFGTVNLVKVKT : :. :. : ** * * * mek-2_Cele TGVIMARKLVHLEIKPSVRQQIVKELAV--LHKCNSPFIVGFYGAFVDNNDI-SICMEYM Dsor1_Dmel THLIMARKLIHLEVKPAIKKQILRELKV--LHECNFPHIVGFYGAFYSDGEI-SICMEYM MAP2K1_Mmus SGLVMARKLIHLEIKPAIRNQIIRELQV--LHECNSPYIVGFYGAFYSDGEI-SICMEHM MAP2K2_Mmus SGLIMARKLIHLEIKPAVRNQIIRELQV--LHECNSPYIVGFYGAFYSDGEI-SICMEHM MAP2K1_Hsap SGLVMARKLIHLEIKPAIRNQIIRELQV--LHECNSPYIVGFYGAFYSDGEI-SICMEHM MAP2K2_Hsap SGLIMARKLIHLEIKPAIRNQIIRELQV--LHECNSPYIVGFYGAFYSDGEI-SICMEHM MEK_Spur SGMVMARKLIKLEIKPAIRNQIIRELKV--LHECNSPYIVGFFGAYYSDGEI-CICMENM CC1G_02205_Ccin TGTIMAKKSVLIDAKSSVRKQILRELDI--MHECQSDYIISCFGSFLAEPNI-CICMEFM CC1G_03368_Ccin TKMIMAKKTVLIDAKPSVRKQILRELHI--MHDCRSDYIISFYGAFLADNNI-CICMEFM AqueK243_Aque SGIIMARKMILLDIKPTVRNQIMRELKV--LHDCNASYIVGFFGSFHVNNEI-SILMQHM GK083_Glam TGQLCAMKEIRISDEEQTQKNIYREIKASISLSCN-PYMVKTYNIYSHPGSILHILLEFC : : * * : :. : :::* :*: .*. .:: :. : .* * :: mek-2_Cele DGLSLDIVLKKV--GRLPEKFVGRISVAVVRGLTYLKDEIKILHRDVKPSNMLVNSNGEI Dsor1_Dmel DGGSLDLILKRA--GRIPESILGRITLAVLKGLSYLRDNHAIIHRDVKPSNILVNSSGEI MAP2K1_Mmus DGGSLDQVLKKA--GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI MAP2K2_Mmus DGGSLDQVLKEA--KRIPEDILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEI MAP2K1_Hsap DGGSLDQVLKKA--GRIPEQILGKVSIAVIKGLTYLREKHKIMHRDVKPSNILVNSRGEI MAP2K2_Hsap DGGSLDQVLKEA--KRIPEEILGKVSIAVLRGLAYLREKHQIMHRDVKPSNILVNSRGEI MEK_Spur DGGSLDQVMKSAPKGRIPENILGKVTVAVLRGLIYLRDVHDIMHRDVKPSNILVNSRGEI CC1G_02205_Ccin DKGSFDGIYKKL--GPLQVEVVGMVALSVLEGLTYLYDVHRIMHRDIKPSNILFNSQGQI CC1G_03368_Ccin DKGSLDGIYKKI--GAIDIDIVGKIALAVLEGLTYLYDVHRIIHRDIKPSNILCNSRGQI AqueK243_Aque DGGSLDLVLN-T--GRIPVDMIGQITVAVLNGLKYLRDTHHIIHRDVKPSNILVNSEGEI GK083_Glam KYGSSQDMLKKLKTGKLTENALAVFIIDTLRGLAYLHDNCKIIHRDIKSANILIDEHGYC . * : : : : . :. . : .:.** ** : *:***:*.:*:* :. * mek-2_Cele KLCDFGVSGMLID----SMANSFVGTRSYMAPERLT--GSHYTISSDIWSFGLSLVELLI Dsor1_Dmel KICDFGVSGQLID----SMANSFVGTRSYMSPERLQ--GTHYSVQSDIWSLGLSLVEMAI MAP2K1_Mmus KLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ--GTHYSVQSDIWSMGLSLVEMAV MAP2K2_Mmus KLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ--GTHYSVQSDIWSMGLSLVELAI MAP2K1_Hsap KLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ--GTHYSVQSDIWSMGLSLVEMAV MAP2K2_Hsap KLCDFGVSGQLID----SMANSFVGTRSYMAPERLQ--GTHYSVQSDIWSMGLSLVELAV MEK_Spur KLCDFGVSGQLID----SMANSFVGTRSYMSPERLQ--GTHYTVQSDIWSLGLSLVEMAI CC1G_02205_Ccin KLCDFGVSGEVIN----SIANTFVGTSVYMSPERIQSHGDGYSVKSDVWSLGMSLVELAL CC1G_03368_Ccin KICDFGVSGELIN----SIADTFVGTSTYMSPERIQ--GAQYTVKSDVWSLGISLIELAL AqueK243_Aque KLCDFGVSGQLIN----SMANSFVGTRSYMAPERLQ--GEVYSVLSDIWSLGVSLIEMAI GK083_Glam KLADFGVASSVLPNDDEAAMKTFVGSLSYMSPERIQ--NQPYSYVSDVWSMGLTYVELLT *:.****:. :: : .:***: **:***: . *: **:**:*:: :*: mek-2_Cele GRYPVPAPSQAEYATMFNVAENEIELADSLE-EPNY-----H------------------ Dsor1_Dmel GMYPIPPPNTATLESIFADNAEES--GQ-------------------------------- MAP2K1_Mmus GRYPIPPPDAKELELLFGCHV----EGDAAETPPRP-----R------------------ MAP2K2_Mmus GRYPIPPPDAKELEASFGRPVVDGADGEPHSVSPRP-----R------------------ MAP2K1_Hsap GRYPIPPPDAKELELMFGCQV----EGDAAETPPRP-----R------------------ MAP2K2_Hsap GRYPIPPPDAKELEAIFGRPVVDGEEGEPHSISPRP-----R------------------ MEK_Spur GRYPIPAPDETALANLFGYELQA---GETKN-IRKT-----R------------------ CC1G_02205_Ccin GAFPFTDPPDDDDDDL-SDLEG--DS---SSPSPSDAQ-HQRTPTHRDSFLLSKKTAKRA CC1G_03368_Ccin GRFPFSQSDSDESDDEFSDASD--YEGT-LSPQPAGSVSLADLP--------------PP AqueK243_Aque GSYPIPAPPKEQLDEEMRNPP----AG---SLPPRR------------------------ GK083_Glam GSYPYDNV---------------------------------------------------- * :* mek-2_Cele PP-----------SNPASMAIFEMLDYIVNGPPPTL-PK-RFFTDEVIGFVSKCLRKLPS Dsor1_Dmel -----------PTDEPRAMAIFELLDYIVNEPPPKL-EH-KIFSTEFKDFVDICLKKQPD MAP2K1_Mmus TPGRPLS-SY-GMDSRPPMAIFELLDYIVNEPPPKL-PS-GVFSLEFQDFVNKCLIKNPA MAP2K2_Mmus PPGRPISVGH-GMDSRPAMAIFELLDYIVNEPPPKL-PS-GVFSSDFQEFVNKCLIKNPA MAP2K1_Hsap TPGRPLS-SY-GMDSRPPMAIFELLDYIVNEPPPKL-PS-GVFSLEFQDFVNKCLIKNPA MAP2K2_Hsap PPGRPVS-GH-GMDSRPAMAIFELLDYIVNEPPPKL-PN-GVFTPDFQEFVNKCLIKNPA MEK_Spur -----VG-GV-FSDSPRPMAIFELLNYIVEEHPPRL-PS-RAFSEEFVDFVDVCLIKNPN CC1G_02205_Ccin SKRRSKL-TYNPDGQLSTMSIFELIHQIVQEPSPRL-PS-DKFPADAVDLVDICLLKNPE CC1G_03368_Ccin KPRRQKN-AN-GNGSTTKKDKRKSKGHIVNEPAPRLTPE-GRYPKAAESFIDACLLKDPD AqueK243_Aque ---NPYA-SH-A--NAIRMPVFELLQMIFTDDPPRL-PD-EYFDDKFKSFVALCLQKDVK GK083_Glam ------------------NSFWDAMNVIVNGAPPLL-KEDAGYSPGLCDLVNAMLEKDPS . *. .* * : :: * * mek-2_Cele ERATLKSLTA--DVFFTQYADHDDQGE----FAVFVKGTINLPK-----------LNP Dsor1_Dmel ERADLKTLLS--HPWIRKAE--LEEVD----ISGWVCKTMDLP-P-STPK--RNTSPN MAP2K1_Mmus ERADLKQLMV--HAFIKRSD--AEEVD----FAGWLCSTIGLNQP-STPT---HAASI MAP2K2_Mmus ERADLKLLMN--HAFIKRSE--GEEVD----FAGWLCRTLRLKQP-STPT----RTAV MAP2K1_Hsap ERADLKQLMV--HAFIKRSD--AEEVD----FAGWLCSTIGLNQP-STPT---HAAGV MAP2K2_Hsap ERADLKMLTN--HTFIKRSE--VEEVD----FAGWLCKTLRLNQP-GTPT----RTAV MEK_Spur ERADLKKLKV--HTFAIMSE--EARVD----FAGWICATMGMSPP-HNDTVKPLQTAV CC1G_02205_Ccin ERQTPKALLVRNHPWIVAIR--ESDFD----IQAFA-------------------ATV CC1G_03368_Ccin ARQTPKDLLK--HEWIENAR--MSSVD----VEAWA-------------------NTF AqueK243_Aque KRGTLSALLE--HKFVEESS--KAKVD----FASWVKRTIDANALIGTP-----TSIT GK083_Glam KRMTAAQLLK--LPFCKKYL--AKEEDLRKLFVKWVQDN-----------------LK * * : : . :