CLUSTAL W (1.83) multiple sequence alignment sek-1_Cele M-----------E-RKGRERKLPGMKI----V-MP-TPVETPTMNLEDRCLIKLTNESEE lic_Dmel M-----------S-KR--HRL-TPFTI----AKEP-EAAIVPPRNLDSRATIQIGDRT-- MAP2K3_Mmus MESPAASPPASLPQTKGKSKRKKDLRISC-VSKPP-VSNPTPPRNLDSRTFITIGDRN-- MAP2K6_Mmus M-----------SQSKGK-KRNPGLKIPKEAFEQP-QTSSTPPRDLDSKACISIGNQN-- MAP2K6_Hsap M-----------SQSKGK-KRNPGLKIPKEAFEQP-QTSSTPPRDLDSKACISIGNQN-- MAP2K3_Hsap MESPASSQPASMPQSKGKSKRKKDLRISC-MSKPP-APNPTPPRNLDSRTFITIGDRN-- MEK3_Spur M-----------A-TKGK-KKFGGVKFKFDAEEAPKREEKKPPGGLDNKATLTVNGHE-- * : : . : * *. .*:.: : : .. sek-1_Cele IEIAATDLVVLEELGKGGYGIVEKMQHRQSGIIMAVKRIKSSINDQSQKQMLNELDACRR lic_Dmel FDIDADSLEKICDLGRGAYGIVDKMRHKQTDTVLAVKRIPMTVNIREQHRLVMDLDISMR MAP2K3_Mmus FEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNTQEQKRLLMDLDINMR MAP2K6_Mmus FEVKADDLEPIVELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDVSMR MAP2K6_Hsap FEVKADDLEPIMELGRGAYGVVEKMRHVPSGQIMAVKRIRATVNSQEQKRLLMDLDISMR MAP2K3_Hsap FEVEADDLVTISELGRGAYGVVEKVRHAQSGTIMAVKRIRATVNSQEQKRLLMDLDINMR MEK3_Spur FQVYARDMIVIENLGRGAYGIVDKTRHEPTESIMAVKKMRAQVNSTEDKRILMDMDVAMR ::: * .: : :**:*.**:*:* :* : ::***:: :* .::::: ::* * sek-1_Cele SDCCPQMVRFYGAMFREGDVWICMEVMDTSLDKFYRHAYK-IGKHIPEPFIGKMALSVIE lic_Dmel SSDCPYTVHFYGAMYREGDVWICMEVMSTSLDKFYPKVFL-HDLRMEESVLGKIAMSVVS MAP2K3_Mmus TVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLE-KNMKIPEDILGEIAVSIVR MAP2K6_Mmus TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID-KGQTIPEDILGKIAVSIVK MAP2K6_Hsap TVDCPFTVTFYGALFREGDVWICMELMDTSLDKFYKQVID-KGQTIPEDILGKIAVSIVK MAP2K3_Hsap TVDCFYTVTFYGALFREGDVWICMELMDTSLDKFYRKVLD-KNMTIPEDILGEIAVSIVR MEK3_Spur SSDCVYTVEFYGALFQEGDVWICMEVMDTCLDKLYKNKLKPQKIFVPENILSRISFSIVS : * * ****:::*********:*.*.***:* : : * .:..::.*:: sek-1_Cele GLNFMKEQLNLIHRDVKPSNILLNRHGQVKICDFGISGHLTNSMAKTVQAGCKPYMPPER lic_Dmel ALHYLHAQLKVIHRDVKPSNILINRAGQVKICDFGISGYLVDSIAKTIDAGCKPYMAPER MAP2K3_Mmus ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPER MAP2K6_Mmus ALEHLHSKLSVIHRDVKPSNVLINTLGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER MAP2K6_Hsap ALEHLHSKLSVIHRDVKPSNVLINALGQVKMCDFGISGYLVDSVAKTIDAGCKPYMAPER MAP2K3_Hsap ALEHLHSKLSVIHRDVKPSNVLINKEGHVKMCDFGISGYLVDSVAKTMDAGCKPYMAPER MEK3_Spur ALKYLQTRLKVIHRDVKPSNVLANHNGKIKLCDFGISGQLVNSMAKTQDAGSRQYMAPER .*..:: :*.:*********:* * *::*:******* *.:*:*** :**.: **.*** sek-1_Cele IDGET-KSAYDVRADVWSLGITIIEIAVGTHPYANWKTPFEQLKQVVKEPPPKLPMESGF lic_Dmel IDPQGNPAQYDIRSDVWSLGIGMIEMATGRYPYDNWRTPFEQLRQVVEDSPPRLPEG-TF MAP2K3_Mmus INPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPAD-QF MAP2K6_Mmus INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KF MAP2K6_Hsap INPELNQKGYSVKSDIWSLGITMIELAILRFPYDSWGTPFQQLKQVVEEPSPQLPAD-KF MAP2K3_Hsap INPELNQKGYNVKSDVWSLGITMIEMAILRFPYESWGTPFQQLKQVVEEPSPQLPAD-RF MEK3_Spur IDPDMSAKGYDVKSDVWSFGITMIEIATNAYPYERWHDMFQQLTQVVKGTSPALPKE-KF *: : *.:::*:**:** :**:* .** * *:** ***: ..* ** * sek-1_Cele SVDCQYFVKRCLEKDYNERPKYPELLAMPFMEQARNEKQFSMARFINEVRFAAIKKTIFL lic_Dmel SPEFEDFIAVCLQKEYMARPNYEQLLKHSFIVEHLQ-RNTDISEFVARILDLPD----AQ MAP2K3_Mmus SPEFVDFTSQCLRKNPAERMSYLELMEHPFFTLHKT-KKTDIAAFVKEILGE-------- MAP2K6_Mmus SADFVDFTSQCLKKNSKERPTYPELMQHPFFTVHES-KAADVASFVKLILG--------- MAP2K6_Hsap SAEFVDFTSQCLKKNSKERPTYPELMQHPFFTLHES-KGTDVASFVKLILG--------- MAP2K3_Hsap SPEFVDFTAQCLRKNPAERMSYLELMEHPFFTLHKT-KKTDIAAFVKEILGE-------- MEK3_Spur SEDIQDFINKCLKKNCTERPSYTRLLEHEFIKQHADIGDDDVASFISPIIGDT------- * : * **.*: * .* .*: *: .:: *: : sek-1_Cele LKN lic_Dmel PAQ MAP2K3_Mmus -DS MAP2K6_Mmus --D MAP2K6_Hsap --D MAP2K3_Hsap -DS MEK3_Spur NSS .