CLUSTAL W (1.83) multiple sequence alignment mkk-4_Cele MVQEDDEN---------------------------------------------------- VZC374L.1_Cele MDHGDDQD---------------------------------------------------- ZC449.6_Cele MCPRNHYVIT-GGG----------------------GFLGAHLIAALQKNGDRTKCIVVD Mkk4_Dmel MAERPKNLFATGSSRSRNPPDQLSLNNLSIRHPPSSTSSTSS--------GSTSSG--SS MAP2K4_Mmus MAAPSPSGGG--------------------------GSGGGG--------G--TPGPIGP MAP2K4_Hsap MAAPSPSGGG--------------------------GSGGGS--------GSGTPGPVGS MKK4_Spur MALANRDRDA--------------------------EAGRGR--------LSL------- AqueK244_Aque MPAKDRFKHL------------------KANV-PSL------------------------ AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque MHIDVKKPR----------PPRMLFNN---RTP-STPSNSGV--------FSV------- mkk-4_Cele ------------------------------------------------------------ VZC374L.1_Cele ------------------------------------------------------------ ZC449.6_Cele PNPRLSHFSAIDFDKSLVEYEKAQKHREYVYAFNVTGTKFLIEKCKFFGVPRFIYSSSIA Mkk4_Dmel S----------------------------------------------------------- MAP2K4_Mmus P----------------------------------------------------------- MAP2K4_Hsap P----------------------------------------------------------- MKK4_Spur ------------------------------------------------------------ AqueK244_Aque ------------------------------------------------------------ AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque ------------------------------------------------------------ mkk-4_Cele ------------------------------------------------------------ VZC374L.1_Cele ------------------------------------------------------------ ZC449.6_Cele VVFVGKPIYNCDESEPYPLKSEYLDIYSSSKAEAEAFVRSQSTIQFKTTCLRFRAIYGPQ Mkk4_Dmel ------------------------------------------------------------ MAP2K4_Mmus ------------------------------------------------------------ MAP2K4_Hsap ------------------------------------------------------------ MKK4_Spur ------------------------------------------------------------ AqueK244_Aque ------------------------------------------------------------ AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque ------------------------------------------------------------ mkk-4_Cele ---------------------------------------LRNSMSLRP------------ VZC374L.1_Cele ---------------------------------------FP--MFARP------------ ZC449.6_Cele DVTVAEKVVQMVRKNLFMVKISRHGRESVSNMSSGENCGLALH-LANQELSKKEGSHGEV Mkk4_Dmel ----------------------SSQHNHVTRC-FGAQQ----P-QQTP------------ MAP2K4_Mmus ----------------------ASGHPAVSSM-QGKRKALKLN-FANP------------ MAP2K4_Hsap ----------------------APGHPAVSSM-QGKRKALKLN-FANP------------ MKK4_Spur --------------------------------------KLKIH-TSTP------------ AqueK244_Aque ---------------------------------------------VLP------------ AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque ------------------------------------------------------------ mkk-4_Cele ------------------------------------------------------------ VZC374L.1_Cele ------------------------------------------------------------ ZC449.6_Cele YFITDGETVGQYSVWSPLIKALGKTPPHHFVSCLLVSTFVSLSSYLCYKIFNSSPPMTRF Mkk4_Dmel ------------------------------------------------------------ MAP2K4_Mmus ------------------------------------------------------------ MAP2K4_Hsap ------------------------------------------------------------ MKK4_Spur ------------------------------------------------------------ AqueK244_Aque ------------------------------------------------------------ AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque ------------------------------------------------------------ mkk-4_Cele ------------------------------------------------------------ VZC374L.1_Cele ------------------------------------------------------------ ZC449.6_Cele ELEVLITDNTYSIEKARRELGYCPEQNLFEKTVEYYRLKAKPKLHQSENSKNHMTMEVVL Mkk4_Dmel ------------------------------------------------------------ MAP2K4_Mmus ------------------------------------------------------------ MAP2K4_Hsap ------------------------------------------------------------ MKK4_Spur ------------------------------------------------------------ AqueK244_Aque ------------------------------------------------------------ AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque ------------------------------------------------------------ mkk-4_Cele ------------------------------------------------------------ VZC374L.1_Cele ------------------------------------------------------------ ZC449.6_Cele FLSISEIFKDESYFLLLNFRLTCLFQLFPYPQIMQSLSSMLSPLNTNNTVYSDDVRPRSQ Mkk4_Dmel ------------------------------------------------------------ MAP2K4_Mmus ------------------------------------------------------------ MAP2K4_Hsap ------------------------------------------------------------ MKK4_Spur ------------------------------------------------------------ AqueK244_Aque ------------------------------------------------------------ AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque ------------------------------------------------------------ mkk-4_Cele ------------------------------TS-LSTRPT--------------------- VZC374L.1_Cele ------------------------------VF-LANRPT--------------------- ZC449.6_Cele ETTSTNFQTPLTITIPPIEYDIPACQFNQQPLLTSKSPELDALVKLNKEIGNQYTYQMFD Mkk4_Dmel ------------------------------PVASSQVPP--------------------- MAP2K4_Mmus ------------------------------PVKSTARFT--------------------- MAP2K4_Hsap ------------------------------PFKSTARFT--------------------- MKK4_Spur ------------------------------NL-LEKQPE--------------------- AqueK244_Aque ------------------------------AKKTSPLPP--------------------- AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque ---------------------------------TTPTPT--------------------- mkk-4_Cele ------------------------------------------------------------ VZC374L.1_Cele ------------------------------------------------------------ ZC449.6_Cele VEKASNSNHHLGFQNDPRMAYDKIIYTSTNKLGCNDFYYQCAYGEPKTDRMAIRHKLDND Mkk4_Dmel ------------------------------------------------------------ MAP2K4_Mmus ------------------------------------------------------------ MAP2K4_Hsap ------------------------------------------------------------ MKK4_Spur ------------------------------------------------------------ AqueK244_Aque ------------------------------------------------------------ AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque ------------------------------------------------------------ mkk-4_Cele ---------------------------------SLSVNGNEKTLPEES------------ VZC374L.1_Cele ---------------------------------LESLSSNDGSVAEEN------------ ZC449.6_Cele DIEPAAKRHCAGELDYSRFGNERKVLTKFVTFSLPPK-SSYSDMPHETKKNSLKRNYPDR Mkk4_Dmel ---------------------------------VPAASSSSAADRHRE------------ MAP2K4_Mmus ---------------------------------LNPN-TTGVQNPHIE------------ MAP2K4_Hsap ---------------------------------LNPN-PTGVQNPHIE------------ MKK4_Spur ---------------------------------INNG--PSQEREQLN------------ AqueK244_Aque ---------------------------------IVDL--PD------------------- AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque ---------------------------------TPASSLSSATPVTAE------------ mkk-4_Cele ------------------------------------------------------------ VZC374L.1_Cele ------------------------------------------------------------ ZC449.6_Cele DDDQLHKETEGVLTNVVSILKTQENQDVAPSFTDQSTLLSIKEIEAVGALSDGQVRRMSS Mkk4_Dmel ------------------------------------------------------------ MAP2K4_Mmus ------------------------------------------------------------ MAP2K4_Hsap ------------------------------------------------------------ MKK4_Spur ------------------------------------------------------------ AqueK244_Aque ------------------------------------------------------------ AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque ------------------------------------------------------------ mkk-4_Cele ------------------------------------------------------------ VZC374L.1_Cele ------------------------------------------------------------ ZC449.6_Cele SRVHANRVASDRGNIPSLMNTPVNNDEISRFFFYTPHILSFCFSKTFEDYEIYHTSFFCS Mkk4_Dmel ------------------------------------------------------------ MAP2K4_Mmus ------------------------------------------------------------ MAP2K4_Hsap ------------------------------------------------------------ MKK4_Spur ------------------------------------------------------------ AqueK244_Aque ------------------------------------------------------------ AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque ------------------------------------------------------------ mkk-4_Cele ------------------------------------------------------VLRS-- VZC374L.1_Cele ------------------------------------------------------PLRS-- ZC449.6_Cele TSSRKRQLQQPAMPDANGHTYAFAPPRNRHNLAKLNLSGMRNPEPDLTNEDNMNSLDYVK Mkk4_Dmel ------------------------------------------------------RIRQ-- MAP2K4_Mmus ------------------------------------------------------RLRTHS MAP2K4_Hsap ------------------------------------------------------RLRTHS MKK4_Spur ------------------------------------------------------SMRSRS AqueK244_Aque ------------------------------------------------------------ AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque ------------------------------------------------------IL-PVN mkk-4_Cele -LSTGTLKYPD-DEHLYTFSSANLQDLGAIGNGNFGTVYKMRHKETGKLIAVKRIRCNN- VZC374L.1_Cele -MSTGILKFPD-DAHLYPFNHTNLRHLSQVGAGYYGTVHKMQHNESGRLIAVKKIRYN-- ZC449.6_Cele KYLSNTLVLPPN-DRIHEFERDHLQELELLGNGSFGVVRKMLHRPSNVEMAVKQISLINN Mkk4_Dmel -QACGKLQFGEGGANTHTFTSDDLEDEGEIGRGAFGAVNKMTFKKLDKVMAVKRIRSTV- MAP2K4_Mmus IESSGKLKISP--EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTV- MAP2K4_Hsap IESSGKLKISP--EQHWDFTAEDLKDLGEIGRGAYGSVNKMVHKPSGQIMAVKRIRSTV- MKK4_Spur MESIGKLSISP--DETYEFTSADLEDMGEIGRGAFGSVNKMWHKQSQSIMAVKRIRSTV- AqueK244_Aque ---ATTIQI-D--DKSVKLSKTELYDVSEIGRGQFGQVNKMTHMVTGKVMAVKRIRVTP- AqueK245_Aque ----------------FELSVDDLDVEEELGRGQYGQVNRMKHKPTGKIMAVKRIRATP- AqueK246_Aque F-EVDKLHIG---DEVYTCGNDDLQDIGSIGEGHFGVVSKMNHTTAKHIMAVKKIPMK-- .* :* * :* * :* . :***:* mkk-4_Cele -IG---HREQIRLLREHDTIVKSEKGPNIVKFYGAIFSEGDCWICMELMDISMDLLYKRV VZC374L.1_Cele --N---ICDQTRLLKEHDTHMKSENVPNIVKFFGACFSEGDCWICMELMDISIDFLYKRV ZC449.6_Cele GPDDAFNKSMQRFRLEVEATKAASNCDEIVRYYGITFNEGVAWMCMELMDLSLDKLYMIA Mkk4_Dmel --D---EKEQKQLLMDLEVVMKSNECIYIVQFYGALFKEGDCWICMELMDTSLDKFYKYI MAP2K4_Mmus --D---EKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYV MAP2K4_Hsap --D---EKEQKQLLMDLDVVMRSSDCPYIVQFYGALFREGDCWICMELMSTSFDKFYKYV MKK4_Spur --D---EKDQKQLLMDLDVVKRSANCVYIIKFFGALFKEGDCWICMELMDSSLDKFYRFV AqueK244_Aque --D---QAKSKSLLMEWKVPKNSVECPYTILFYGAFFCENDVWICMELMDRSLEELYHLV AqueK245_Aque --D---QAENKRLLMDYNVAMRSIDCPFTITFYGALFREGDVWICMELMDKSLDKLYQLV AqueK246_Aque --D---LRTSGGNVLELDVIKKVKECPFIVHFYGCLLREGHVWICMELLDSSMAQVSEIV . : .. . : ::* : *. *:****:. *: . mkk-4_Cele YMVKNSRLNENVVGHITVCTVDALDYLKKELKIIHRDVKPSNILVDGTGAVKLCDFGICG VZC374L.1_Cele YSVKKSRLNENIIGHITVCIVDALDYLKRKLNRIHRDVKPSNILINAAGDVKLCDFGICG ZC449.6_Cele HDIQKVEIPEQILGAVAVATIRALEHLKTTHHIIHRDIKPSNILLDRHGCVKLCDFGICG Mkk4_Dmel YEKQQRHIPESILAKITVATVNALNYLKEELKIIHRDVKPSNILLHRRGDIKLCDFGISG MAP2K4_Mmus YSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISG MAP2K4_Hsap YSVLDDVIPEEILGKITLATVKALNHLKENLKIIHRDIKPSNILLDRSGNIKLCDFGISG MKK4_Spur HEVQNTYIPENIMGKVAYATVKALNYLKETLKIIHRDVKPSNILLDRGGNIKLCDFGISG AqueK244_Aque YDKLKESIPEL--------TLKALTYLHDKLNVMHRDVKPSNILINQNGEIKLCDFGIAG AqueK245_Aque YKKLNEKIPEVIVGKMADSTLKALTYLHDELQVMHRDVKPSNILINKKGEIKLCDFGIAG AqueK246_Aque YNKMNERIPEDILGKMTVAVINALHFLQKELKIIHRDVKPSNILVSKVGEFKLCDFGISG : . : * : ** .*: : :***:******: * .*******.* mkk-4_Cele QLEESFAKTHDAGCQPYLAPERITS---SDKYDVRSDVWSLGITLYEIATGKFPYQ--EW VZC374L.1_Cele DLVGSYAITVEAGCVQYLAPERIEN---MDKYDIRSDVWSLGITLYEIATGVYPYR--GW ZC449.6_Cele YLQNSVAQSVDVGCRPYMAPERLAPN--GDGYDIKSEVWSLGITMVEVANGKYPYD--GF Mkk4_Dmel QLVDSIAKTKDAGCRPYMAPERIDPER-AKGYDVRSDVWSLGITLMEVATGNFPYR--KW MAP2K4_Mmus QLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYP--KW MAP2K4_Hsap QLVDSIAKTRDAGCRPYMAPERIDPSASRQGYDVRSDVWSLGITLYELATGRFPYP--KW MKK4_Spur QLVDSIARTMDAGCKPYMAPERIDPFQSRPGYDIRSDVWSLGITMYEVATGEFPYP--KW AqueK244_Aque ELVDSLAKT-DIGCRPYLAPERIDEP--QHEYDHRSDVWSLGITMYEIAMGEFPYPVDTL AqueK245_Aque ELVNSLAKT-DIGCRPYLAPERIYGG--QHKYDHRSDVWSLGITLCELATGEFPYP--PY AqueK246_Aque KLVDSIARTMDVGCRPYMAPERIDPARACLGYTIQSDVWSYGITLVELAQGSFPYK--KW * * * : : ** *:****: * :*:*** ***: *:* * :** mkk-4_Cele N--SLFDQIATVVSGDPPILHPDSDDFHYSLPLVKFINTCLTKDRRHRPKYDTLKSFDFY VZC374L.1_Cele S--NQMEHIEIVVNGDSPILLQNMHNLHYTDPLCRFINTCLRKNKDDRPKYVNLKTFSFY ZC449.6_Cele MDAPILDQVRMVVYGDPPILDSD---HEVSMSMKRFIALCTIKDRNLRASFDDLKKTNIY Mkk4_Dmel D--SVFEQLCQVVQGEPPRLLTSYNGMEFSKEFVDFVNTCLIKKESDRPKYSRLLEMPFI MAP2K4_Mmus N--SVFDQLTQVVKGDPPQLSNS-EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI MAP2K4_Hsap N--SVFDQLTQVVKGDPPQLSNS-EEREFSPSFINFVNLCLTKDESKRPKYKELLKHPFI MKK4_Spur N--SVFEQLSQVVKGDPPRLKHN-DFYSYSEDFISFVNKCLTKDEKYRPKYKNLLEYKFI AqueK244_Aque R--SIFGLIEMIVKGSPPRLTSD----RFSGEHKDFVAQCLTKSRDSRPRYKDLNAHSFI AqueK245_Aque R--NLFEQIKLVVEGAPPQLPDD---GTFSEDFRDFVSKWY------------------- AqueK246_Aque N--TIFDQLNAVVSGDPPSLPPE----NFTRELREFTAACLVKDSDQRPNYVQLQEKEFF : : :* * .* * . : * mkk-4_Cele RIYAVAG--PEIEEAK-------------------------------------------- VZC374L.1_Cele KMYAVGG--PDIEEAK-------------------------------------------- ZC449.6_Cele RDYIQEEHRVTDGCVSVVFHRKFSTCQLYGHDGTHNGAEVVYLEDHDFYIRSSWDGQCQD Mkk4_Dmel RRGETSH--TDVAVYVA------------------------------------------- MAP2K4_Mmus LMYEERT--VEVACYVC------------------------------------------- MAP2K4_Hsap LMYEERA--VEVACYVC------------------------------------------- MKK4_Spur KDYEHAN--IDVATFVS------------------------------------------- AqueK244_Aque QTIENTG--VDMHCWYT------------------------------------------- AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque VLYNSGRVSVDVSSWYE------------------------------------------- mkk-4_Cele --------------------------RIL-GV---------------------------- VZC374L.1_Cele --------------------------RIL-GL---------------------------- ZC449.6_Cele KIAPIRGYKQNIQQLQTPQISTLPKAQTIPNLPKFENSDFPKDPNPQVIRDNVRKAPVHF Mkk4_Dmel --------------------------DILESMEK----D--------------------- MAP2K4_Mmus --------------------------KILDQMPA-------------------------- MAP2K4_Hsap --------------------------KILDQMPA-------------------------- MKK4_Spur --------------------------EILLAMRS-------------------------- AqueK244_Aque --------------------------TILTKYND----DLPP------------------ AqueK245_Aque ------------------------------------------------------------ AqueK246_Aque --------------------------R--------------------------------- mkk-4_Cele -------------------------------------EAIDTRNHPVDHRG VZC374L.1_Cele -------------------------------------EAIDARDHPVEQRA ZC449.6_Cele ENSIVQEIERQAMEDEFDMDYLTTTSPPKKRTHPDIITSFRNSAHNYSKLQ Mkk4_Dmel -----------------------------------GIT---QFTANQQAES MAP2K4_Mmus ------------------------------------------TPSSPMYVD MAP2K4_Hsap ------------------------------------------TPSSPMYVD MKK4_Spur ------------------------------------------------TSQ AqueK244_Aque ----------------------------------DKTE--PSATNVPELVS AqueK245_Aque ---------------------------------------------VVLKLS AqueK246_Aque ----------------------------------------------VKESK