CLUSTAL W (1.83) multiple sequence alignment jkk-1_Cele MENVCFQ---QRLRDLETRVRKW-----K--FLKLG--------LTEVRLRPRDRRSTS- mek-1_Cele MERD------------------------------FD--------LGMGRPGG-------- hep_Dmel MSTIEFETIGSRLQSLEAKLQAQNE-SHDQIVLSGARGPVVSGSVPSARVPPL-ATSASA MAP2K7_Mmus MAASSLE---QKLSRLEAKLKQENREARRRIDLNLD--------ISPQRPRPIIVITLSP MAP2K7_Hsap MAASSLE---QKLSRLEAKLKQENREARRRIDLNLD--------ISPQRPRPIIVITLSP MKK7_Spur MNRR---------------------------DQRFY--------IAFCR----------P AqueK248_Aque ------------------------------------------------------------ jkk-1_Cele ---------------------------------VDQKHKECSSTSSSPQHQ--------- mek-1_Cele ------------------------------------------------------------ hep_Dmel ATSATHAPSLGAGSVSGSGISIAQRPAPPVPHA-TPFGSASASSSSSSASAFASAAPATG MAP2K7_Mmus APA------------------PSQRAALQLPLA-NDGGSRSPSSESSPQHP--------- MAP2K7_Hsap APA------------------PSQRAALQLPLA-NDGGSRSPSSESSPQHP--------- MKK7_Spur APR------------------YGQRGLPTLPLQLNHNGGLSPHAR--------------- AqueK248_Aque ------------------------------------------------------------ jkk-1_Cele ------RPN----N-------------IGYLTSPMERKFTPLSMKPSP-SRRDTEKDALE mek-1_Cele ---------------------------LGGLGGEPIMQQMPQPAPHH--PSRSSNDHNVK hep_Dmel TFGGTYTPPTTRVSRATPTLPMLSSGPGGGLNRTRP-VILPLPTPP------HPPVSETD MAP2K7_Mmus ------TPP------------------------TRPRHMLGLPST--LFTPRSMESIEID MAP2K7_Hsap ------TPP------------------------ARPRHMLGLPST--LFTPRSMESIEID MKK7_Spur ----------------------------------RDKKQVQMPLTCGPINRSTIDGPEID AqueK248_Aque ------------------------------------------------------------ jkk-1_Cele YEFLEGYKKSGTLEIDGE------------------------------------------ mek-1_Cele NLMKQAEENSGYLTLQGN------------------------------------------ hep_Dmel MKLKIIMEQTGKLNINGR------------------------------------------ MAP2K7_Mmus QKLQEIMKQTGYLTIGGQ------------------------------------------ MAP2K7_Hsap QKLQEIMKQTGYLTIGGQ------------------------------------------ MKK7_Spur RKLQEIMKQTGLLTTEGKRSTTLPVPKGAWFGCHADVSDRTCQNSLSSGRVLTLASQRLP AqueK248_Aque -----------------Q------------------------------------------ . jkk-1_Cele ------------------------------------------------------------ mek-1_Cele ------------------------------------------------------------ hep_Dmel ------------------------------------------------------------ MAP2K7_Mmus ------------------------------------------------------------ MAP2K7_Hsap ------------------------------------------------------------ MKK7_Spur ELCLRVALAILNAAGDRPIIRARHSSRGLKALKSTSFRGLRTLLPPVGALPLDPIRFRLG AqueK248_Aque ------------------------------------------------------------ jkk-1_Cele ------------KQVVDPNEIHIISLLGSGSCGVVESATVR--SKLMAVKTMY-KNDNKE mek-1_Cele ------------RRKADLKELQFVEDIGHGSCGTVTKCRYK--SVIMAVKTMP-RTSNSY hep_Dmel ------------QYPTDINDLKHLGDLGNGTSGNVVKMMHLSSNTIIAVKQMR-RTGNAE MAP2K7_Mmus ------------RYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHIIAVKQMR-RSGNKE MAP2K7_Hsap ------------RYQAEINDLENLGEMGSGTCGQVWKMRFRKTGHVIAVKQMR-RSGNKE MKK7_Spur RYAPSQHSQTYRRYHINVESLESIGELGFGSCGHVIRMRHKESGTILAVKQMR-RSGNKE AqueK248_Aque ------------TYPFSMEDMLDVKRVGSGISGEVYRMVHNPSSIAIAAKKMLWQHDTWE . :.: : :* * .* * . :*.* * : .. jkk-1_Cele NLKRILRDVRIM-SMCNSPFIVTSYGYFMFDSSVKICMQIMSACCEKLLRRIYHSKLDFF mek-1_Cele EMSRILMDLDVICLSFDCPYIVRCFGYFITNFDVRVCMECMATCLDRLLIRIKQ----PI hep_Dmel ENKRILMDLDVVLKSHDCKYIVKCLGCFVRDPDVWICMELMSMCFDKLLKLSKK----PV MAP2K7_Mmus ENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQG----PI MAP2K7_Hsap ENKRILMDLDVVLKSHDCPYIVQCFGTFITNTDVFIAMELMGTCAEKLKKRMQG----PI MKK7_Spur ENKRILMDLDVVLKSHNCPFIVQCLGAIVTPSEVWICMEQMATCLDKLIKKLRE----PV AqueK248_Aque EQRRVLMDLEVM-NSQHSPFIVEYYGSAIVKNEVWVFMELMATCLDRLLKRLKG----PI : *:* *: :: .. :** * : .* : *: *. * ::* . jkk-1_Cele PEFVAGHIVYSAISALDYLKEKHSIIHRDIKPSNILFDDSGNVKLCDFGISGFMTDSMAH mek-1_Cele PERIIGKLSVSIIKALHYLKTKHQIMHRDVKPSNILLDWSGVIKLCDFGIAGRLIESRAH hep_Dmel PEQILGKVTVATVNALSYLKDKHGVIHRDVKPSNILIDERGNIKLCDFGISGRLVDSKAN MAP2K7_Mmus PERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAK MAP2K7_Hsap PERILGKMTVAIVKALYYLKEKHGVIHRDVKPSNILLDERGQIKLCDFGISGRLVDSKAK MKK7_Spur PEQIIGKMVVAIVNALNYLKEKHGVMHRDVKPSNMLLDEKGVVKLCDFGISGRLVDSKAR AqueK248_Aque PERIIGKMCVSIVKALDYLKRAHKVIHRDVKPSNILIDVNGNVKLCDFGISGRLVDSKAF ** : *:: : :.** *** * ::***:****:*:* * :*******:* : :* * jkk-1_Cele SKSAGCPPYMAPERLTIET--NSKYDVRSDVWSLGITV-------YQLVTGLYPFPLN-- mek-1_Cele SKQAGCPLYMGPERLDPNN--FDSYDIRSDVWSFGVTL-------VELATGQYPYAG--- hep_Dmel TRSAGCAAYMAPERIDP---KKPKYDIRADVWSLGITL-------VELATARSPYEGC-- MAP2K7_Mmus TRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLQCLSPSQVELATGQFPYKNC-- MAP2K7_Hsap TRSAGCAAYMAPERIDPPDPTKPDYDIRADVWSLGISLPCPSPSQVELATGQFPYKNC-- MKK7_Spur TRSAGCAAYMAPERIDPPDPNNPDYDVRADVWSLGISL-------VTISFASY------- AqueK248_Aque TRGAGAAAYMAPERINMSHD-SKGYDVRADVWSLGISL-------VEMATGSAPYKFNEF :: **.. **.***: **:*:****:*::: : . jkk-1_Cele DMEFTTLTIIANLNLPSPSLREETKRSFSPLFIEFLDLCLRKDVRERPEYRQLMKHDFYL mek-1_Cele -TEFDMMSKILN--DEPPRLDP---AKFSPDFCQLVESCLQRDPTMRPNYDMLLQHPFVV hep_Dmel NTDFEVLTKVLD--SEPPCLPYGEGYNFSQQFRDFVIKCLTKNHQDRPKYPELLAQPFIR MAP2K7_Mmus KTDFEVLTKVLQ--EEPPLLPGH--MGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIK MAP2K7_Hsap KTDFEVLTKVLQ--EEPPLLPGH--MGFSGDFQSFVKDCLTKDHRKRPKYNKLLEHSFIK MKK7_Spur ------------------------------------------------------------ AqueK248_Aque SSEFDLLTHIVQ--APPPLLDE---DKFSPNFYDFVAQCLCKDVDERPQYDKLLLHPLIK jkk-1_Cele DYDPASGSAYKFKAINGKCNQVADWFVDVIRLSKTE--DELKS----------------- mek-1_Cele HHEKIE-------------TDVEEWFADVMGDDSAYHNSNEISNLTDQYAQSLQQQIQLL hep_Dmel IYESAK-------------VDVPNWFQSIK--DNRLRANGDPT----------------- MAP2K7_Mmus HYEILE-------------VDVASWFKDVMAKTESPRTSGVLS----------------- MAP2K7_Hsap RYETLE-------------VDVASWFKDVMAKTESPRTSGVLS----------------- MKK7_Spur -----------------------------IT----------------------------- AqueK248_Aque EYEEKP-------------VDVGEWFSEMCSTH--------------------------- jkk-1_Cele ------------------------------------------------------------ mek-1_Cele QIENAFLKEQQVKREENEQERIRNIEMEEQYRADKFRQEQQAKEFEDLQHRRESVSQINQ hep_Dmel ------------------------------------------------------------ MAP2K7_Mmus ------------------------------------------------------------ MAP2K7_Hsap ------------------------------------------------------------ MKK7_Spur ------------------------------------------------------------ AqueK248_Aque ------------------------------------------------------------ jkk-1_Cele ---------------------------IPNT----------------------------- mek-1_Cele SRRGTTTQILARGNEVSINGETWCQLPPHHPPIPAIISDRSQYSQRIGRDRVSRLIIGFC hep_Dmel ---------------------------LQRL----------------------------- MAP2K7_Mmus ---------------------------QHHL----------------------------- MAP2K7_Hsap ---------------------------QPHL----------------------------- MKK7_Spur ------------------------------I----------------------------- AqueK248_Aque ------------------------------------------------------------ jkk-1_Cele --------PCVN mek-1_Cele SKTKLIKCKNRR hep_Dmel --------P-NS MAP2K7_Mmus --------PFFR MAP2K7_Hsap --------PFFR MKK7_Spur --------REAY AqueK248_Aque ---------GIP