CLUSTAL W (1.83) multiple sequence alignment MAP3K2_Mmus MDDQQALNSIMQDLAVLHKASRPALSLQ---------------------------ETR-K MAP3K3_Mmus MDEQEALDSIMKDLVALQMSRRTRLSGY---------------------------ETM-K MAP3K2_Hsap MDDQQALNSIMQDLAVLHKASRPALSLQ---------------------------ETR-K MAP3K3_Hsap MDEQEALNSIMNDLVALQMNRRHRMPGY---------------------------ETM-K MEKK2_Spur MRFQRALEIITLTLAPAAVSAHSAFQGIILPVDPAADSNQVISEITDNLISLRVQGNRNR AqueK227_Aque MADGQLPSIEAGDR---------------------------------------------- * . . MAP3K2_Mmus AKPS-SPKK-------------------------------QNDVRVKFEHRGEKRILQVT MAP3K3_Mmus NKDTGHPNR-------------------------------QSDVRIKFEHNGERRIIAFS MAP3K2_Hsap AKSS-SPKK-------------------------------QNDVRVKFEHRGEKRILQFP MAP3K3_Hsap NKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIAFS MEKK2_Spur GRGS-SSSH-------------------------------STEIRVKFEFNGEKRILQIP AqueK227_Aque ------------------------------------------SVRRRVDEDIHRHLIAGF .:* :.: .:::: MAP3K2_Mmus RPVKLEDLRSKSKIAFGQSMDLHYTNN----ELVIPLTTQDDLDKAVELLDRSIHMKSLK MAP3K3_Mmus RPVRYEDVEHKVTTVFGQPLDLHYMNN----ELSILLKNQDDLDKAIDILDRSSSMKSLR MAP3K2_Hsap RPVKLEDLRSKAKIAFGQSMDLHYTNN----ELVIPLTTQDDLDKAVELLDRSIHMKSLK MAP3K3_Hsap RPVKYEDVEHKVTTVFGQPLDLHYMNN----ELSILLKNQDDLDKAIDILDRSSSMKSLR MEKK2_Spur RPLKYDDILLKARTTFGQPVDMFLTNHNTTFSLLIPIRDQTDLNHAVEITDNNPNAKSLR AqueK227_Aque HPIDPV-------GGGGHNMKPPSLGHT---RTISGLSTQNELDFALSIYERFTGITSLR :*: *: :. .: : * :*: *:.: :. .**: MAP3K2_Mmus ILLVVNGS-----------TQA-TNLEPSPSP--------------------EDLNNTP- MAP3K3_Mmus ILLLSQDRNHTSSSPHSGVSRQ-VRIKPSQSA--------------------GDINTIY- MAP3K2_Hsap ILLVINGS-----------TQA-TNLEPLPSL--------------------EDLDNTV- MAP3K3_Hsap ILLLSQDRNHNSSSPHSGVSRQ-VRIKASQSA--------------------GDINTIY- MEKK2_Spur LHLELATPGSSSN--NNGSSKRDLYDTAIRSSSTIPQSKHTSPSRSQSVPQDHHVHTSH- AqueK227_Aque VVLSRQPVTITAP--PT-----DVLSSASPTPDNLKEQVAKFTQRSQSEPYFMR-NTTEG : * . : .. MAP3K2_Mmus --LGAE----RKKRLSVV--GPPNRDRSSPPPGYIPDELHQIARNGSFTSINSEGEFIPE MAP3K3_Mmus --QAPE----PRSRHLSV--SSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPE MAP3K2_Hsap --FGAE----RKKRLSII--GPTSRDRSSPPPGYIPDELHQVARNGSFTSINSEGEFIPE MAP3K3_Hsap --QPPE----PRSRHLSV--SSQNPGRSSPPPGYVPERQQHIARQGSYTSINSEGEFIPE MEKK2_Spur --DT------THKRYSTQEMPTRDNANPSPPPGYVPANAMVDMGHQSRLQTFGEGTFIPE AqueK227_Aque FRESPDMYFHTYHGFRNI--PEEPSRRDSPPPGFIDEPSTPVPLD---IGGKEGGKFIPE . *****:: . * **** MAP3K2_Mmus SMDQ-MLDPLSLSSPENSGSGSCPSLDSPLDGE---SYP-KSRMPRAQSYPDNHQEFTDY MAP3K3_Mmus TSEQCMLDPLS--SAENSLSGSCQSLDRSADSP---SFR-KSQMSRARSFPDNRKECSDR MAP3K2_Hsap SMDQ-MLDPLSLSSPENSGSGSCPSLDSPLDGE---SYP-KSRMPRAQSYPDNHQEFSDY MAP3K3_Hsap TSEQCMLDPLS--SAENSLSGSCQSLDRSADSP---SFR-KSRMSRAQSFPDNRQEYSDR MEKK2_Spur PPEERIM--V-------SPNGSQQSLDKLRMGSHSLGSA-TGKMFKSQSCA-NHDDFEN- AqueK227_Aque VEDD-DLDNASPAS-------IPSTLDMSFISEENLSITGVDGLLR-------HHEYSLY :: : :** . . . : : :.: MAP3K2_Mmus DNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPR-ARRTQGTSFR-SPVSFSPTDHSL MAP3K3_Mmus ETQLYDKGVKGGTYPRRYHVSVHHKDYNDGRRTFPR-IRRHQGNLF-----TLVPSSRSL MAP3K2_Hsap DNPIFEKFGKGGTYPRRYHVSYHHQEYNDGRKTFPR-ARRTQGTSLR-SPVSFSPTDHSL MAP3K3_Hsap ETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPR-IRRHQGNLF-----TLVPSSRSL MEKK2_Spur -SQVGRGMIKGGTFPSRQSVKPSRIDTEDGRKTFPSRGKRPPLASMHDDQHSISDSLSSL AqueK227_Aque DDKEHGAESLTRTYPREKSYSMGELPSHTHKAM--------YGT---Y-PLNPPPKLHPP *:* . . . : . . . MAP3K2_Mmus STSSGSSVFTPEYD-DSRIRRRGSDIDNPTLT-----VTDISPPSRSPRAPTNWRLGKLL MAP3K3_Mmus STNGENMGVAVQYL-DPRGRLRSADSEN-ALT-----VQERNVPTKSPSAPINWRRGKLL MAP3K2_Hsap STSSGSSIFTPEYD-DSRIRRRGSDIDNPTLT-----VMDISPPSRSPRAPTNWRLGKLL MAP3K3_Hsap STNGENMGLAVQYL-DPRGRLRSADSEN-ALS-----VQERNVPTKSPSAPINWRRGKLL MEKK2_Spur GRSS-SSGISPDYDTDSSIPRRWTEGDLEGLAGGHPKSFNLADNTRSPRAPTNWQRGKLL AqueK227_Aque LSSHYHHKMVPGSS-DSR---RLQDSELPIQK-----LASLT-VSHKITAPARWSKGRLL . . *. * : : . ::. ** .* *:** MAP3K2_Mmus GQGAFGRVYLCYDVDTGRELAVKQVQFN--------PESPETSKEVNALECEIQLLKNLL MAP3K3_Mmus GQGAFGRVYLCYDVDTGRELASKQVQFD--------PDSPETSKEVSALECEIQLLKNLQ MAP3K2_Hsap GQGAFGRVYLCYDVDTGRELAVKQVQFD--------PDSPETSKEVNALECEIQLLKNLL MAP3K3_Hsap GQGAFGRVYLCYDVDTGRELASKQVQFD--------PDSPETSKEVSALECEIQLLKNLQ MEKK2_Spur GQGAFGVVYVCYDADTGRELAVKQVPTE--------NSNTDARKEVQSLKQEIELLRNLQ AqueK227_Aque GTGAFGQVFLCTDLDTQMDMAVKVVDIDHIENIKPSLDSLKMSKEVRSFETEVQLLKNIH * **** *::* * ** ::* * * : .. . *** ::: *::**:*: MAP3K2_Mmus HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYL MAP3K3_Mmus HERIVQYYGCLRDRAEKILTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL MAP3K2_Hsap HERIVQYYGCLRDPQEKTLSIFMEYMPGGSIKDQLKAYGALTENVTRKYTRQILEGVHYL MAP3K3_Hsap HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL MEKK2_Spur HPRIVQYFGCLEE--NGTLSIFMEFMSGGSVKDELRLYGPLTDTVTRKYTRQILEGTAYL AqueK227_Aque HERVVGYYGTER--REGKLFIFMEYLAGGSIYQHLKNTGALSEALTRKYTRQILEGVAFL * *:* *:* . : * ****::.***: :.*: *.*:: :*********** :* MAP3K2_Mmus HSNMIVHRDIKGANILRDSTGNIKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVIS MAP3K3_Mmus HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGIRSVTGTPYWMSPEVIS MAP3K2_Hsap HSNMIVHRDIKGANILRDSTGNVKLGDFGASKRLQTICLSGTGMKSVTGTPYWMSPEVIS MAP3K3_Hsap HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS MEKK2_Spur HDHHIVHRDIKGANVLR-SSGNVKLADFGASTRLQTIHSHITGMKTVTGTPYWMSPEIIN AqueK227_Aque HGMKIVHRDIKGANILRDSNGNVKLADFGASKRLQTIR---SGIGSVHGTPYWMAPEVIK *. **********:** * **:**.*****.***** :*: :* ******:**:*. MAP3K2_Mmus GE-GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDF MAP3K3_Mmus GE-GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDF MAP3K2_Hsap GE-GYGRKADIWSVACTVVEMLTEKPPWAEFEAMAAIFKIATQPTNPKLPPHVSDYTRDF MAP3K3_Hsap GE-GYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDF MEKK2_Spur GE-GYGRRADVWSIGCTVVEMLTTKPPWADYEAMAAIFKIATKETEPVLPQSVSQDARNF AqueK227_Aque GDDPYTFKADIWSVGATVVEMLKCRPPWSDFEPTAAMFKIVMNDTKPDLPPHCSEQAHNF *: * :**:**:..******. :***:::*. **:***. : *:* ** *: ::* MAP3K2_Mmus LKRIFVEA-KLRPSAEELLRHMFVH---YH MAP3K3_Mmus LRRIFVEA-RQRPSAEELLTHHFAQL--VY MAP3K2_Hsap LKRIFVEA-KLRPSADELLRHMFVH---YH MAP3K3_Hsap LRRIFVEA-RQRPSAEELLTHHFAQL--MY MEKK2_Spur LTLCFKKILADRPSAAELLRHNFVRTAPMD AqueK227_Aque IELCFIKDKNERPSAMDLLSHSFCSVFPNT : * : **** :** * *