CLUSTAL W (1.83) multiple sequence alignment MAPKAPK3_Hsap MDGETAEEQ------------------------GG-------------PV--PP------ MAPKAPK2_Hsap MLSNSQGQS------------------------PP------------VPFPAPA------ MAPk-Ak2_Dmel MLSLQN------------------------------------------------------ MAPKAPK3_Mmus MDGETAGEK------------------------GS-------------LV--PP------ MAPKAPK2_Mmus MLSGSPGQT------------------------PP------------APFPSPP------ K08F8.1_Cele MMFEYEEDEDPMEQQKHEEFKHHSTDHSGSPQENPFRFSYDTGKRAASMFVTPSSEDLIA C44C8.6_Cele MQIRVLCVSTA--------------------DFSP------------KNLLGPSSLIF-- MAPKAPK2_Spur MI---------------------------------------------------------- MAPKAPK5a_Spur MDFRTG------------------------------------------------------ AqueK073_Aque MSSHPLTGKA-----------------------PP------------D-FAA-------- * MAPKAPK3_Hsap ------------------P-V-------------------------APGG---------P MAPKAPK2_Hsap ------------------PPP-------------------------QPPT---------P MAPk-Ak2_Dmel ------------------------------------------------------------ MAPKAPK3_Mmus ------------------P-G-------------------------ALGG---------S MAPKAPK2_Mmus ------------------P-P-------------------------A------------- K08F8.1_Cele YGTKHL---------LDSPTAVQRSLVLNATTSLNIDCDLSSDDDLSPTT------QRKI C44C8.6_Cele --RVFFGGFLYANVKLEAPEA-------------------------QKSTRGSFFSRIGC MAPKAPK2_Spur ------------------------------------------------------------ MAPKAPK5a_Spur ------------------------------------------------------------ AqueK073_Aque ------------------------------------------------------------ MAPKAPK3_Hsap --GLGG-----A----P-----------GGRREPKKYAVTDDYQLS-KQVLGLGVNGKVL MAPKAPK2_Hsap --ALPHPPAQPP----PPPPQQFPQFHVKSGLQIKKNAIIDDYKVT-SQVLGLGINGKVL MAPk-Ak2_Dmel ------------------------------QRQPKTTPLTDDYVTS-NTVLGYGINGKVV MAPKAPK3_Mmus --ALGGAP---A----P-----------GVRREPKKYAVTDDYQLS-KQVLGLGVNGKVL MAPKAPK2_Mmus -------PAQPP----PP----FPQFHVKSGLQIRKNAITDDYKVT-SQVLGLGINGKVL K08F8.1_Cele CFCASQNPAETQEQGLRPAKS-TL----AISFPCHQHQITEDYTIS-AEIIGIGESGKVM C44C8.6_Cele CLSTKSSPAEKI----KPP---------DEIMAFHEYPVTQDYRIS-RKVLGVGINGKVV MAPKAPK2_Spur ------------------------------------------------------------ MAPKAPK5a_Spur --------------------------------FFETVSILEDYTIDWTQKLGTGINGPVR AqueK073_Aque -----HVPSA------------------QKPLIPKKHAITGDYTIL-TRSLGVGVNGKVL MAPKAPK3_Hsap ECFHRRTGQKCALKLLYDSPKARQEVDHHWQASGGPHIVCILDVYENMHH------GKRC MAPKAPK2_Hsap QIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYA------GRKC MAPk-Ak2_Dmel QCTHRRTQQNYALKVLLDSERARREVDLHWRVSGCRYIVNIIDVYENTFK------DRKC MAPKAPK3_Mmus ECYHRRSGQKCALKLLYDSPKARQEVDHHWQASGGPHIVRILDVYENMHH------GKRC MAPKAPK2_Mmus RIFDKRTQQKFALKMLQDCPKARREVELHWRASQCPHIVHIVDVYENLYA------GRKC K08F8.1_Cele ACYQKVTGEKFALKVLRDSQKARREVELHWLTNAHENVVSILDIYENTFD------NVKC C44C8.6_Cele ECEHRQSGDKFALKVLRDTQKARREVELHVMASGHGHVVSVHDVYKNSYN------GVDC MAPKAPK2_Spur ------------------------------------------------------------ MAPKAPK5a_Spur PCQHKRSEDRFALKLLLDKPGARAEVNLHSRCSGHANIVKIIEVFSNEVQFPGEPAPKSR AqueK073_Aque ECIHKATGERRALKILRENPKSRRELDLHWRSCSHENIVNICDVYENVFM------GHRS MAPKAPK3_Hsap LLIIMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSHNIAHRDVKPENLL MAPKAPK2_Hsap LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL MAPk-Ak2_Dmel LLVVMECMEGGELFQRIQDKADGAFTEREAAQIMHEICAAVDYLHSRDIAHRDLKPENLL MAPKAPK3_Mmus LLIVMECMEGGELFSRIQERGDQAFTEREAAEIMRDIGTAIQFLHSRNIAHRDVKPENLL MAPKAPK2_Mmus LLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLL K08F8.1_Cele LLMVVEFLEGGDLLSQFESQGSIPYTEKKVGEIIRQIGNAVMYLHDMNIAHRDIKLENIL C44C8.6_Cele LLVVMENMKGGELFNRIQERGQKAFTEREAAGIVNEICSAVAHLHRMSIAHRDLKPENLL MAPKAPK2_Spur -------------------------RLTEAAEIVRSIGQAVHHLHVMNIAHRDLKPENLL MAPKAPK5a_Spur LLVVMELMDGGELFDRISKQ--KRFTERQAVILTKQIASAVLQCHSLNIAHRDLKPENLL AqueK073_Aque LLVVMECMEGGELFDRIQDKG--HFTEREAAEVVRCISLAVAHLHHMDIAHRDLKPENLL :. : . * *: * .*****:* **:* MAPKAPK3_Hsap YTSKEKDAVLKLTDFGFAKETTQ---NALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV MAPKAPK2_Hsap YTSKRPNAILKLTDFGFAKETTSH--NSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV MAPk-Ak2_Dmel YTTTQPNATLKLTDFGFAKETFTS--YTLQTPCYTPYYVAPEVLGPEKYDKSCDIWSLGV MAPKAPK3_Mmus YTSKEKDAVLKLTDFGFAKETTQ---NALQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV MAPKAPK2_Mmus YTSKRPNAILKLTDFGFAKETTSH--NSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV K08F8.1_Cele CSGTGDNCVYKLGDYGFAKRPERN--VLMESPCCTPFYAPPEVLGRERYDKSCDMWSLGV C44C8.6_Cele YVTTASNAALKLTDFGFAKKTDESEPQGLKTACFTPYYCAPEVLGTEKYDKSCDLWSIGV MAPKAPK2_Spur YRDRTPNSLLKLTDFGFAKETTT---TNLQTPCYTPYYVAPEVLGPEKYDKSCDMWSLGV MAPKAPK5a_Spur LKDNSEDSPVKLSDFGFAKVDD----GTLMTPHFTPYYVAPQVSTSL------------- AqueK073_Aque YSDKTPSAKLKLTDFGFAKENHGS--KALTTPCYTPYYVAPEVLGPEKYDTSCDMWSIGV .. ** *:**** : :. **:* .*:* MAPKAPK3_Hsap IMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYGFPNPEWSEVSEDAKQLIRLLLKTDPT MAPKAPK2_Hsap IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPT MAPk-Ak2_Dmel VMYIIMCGFPPFYSNHGLAISPGMKNRIRTGQYDFPDPEWTNVSQAAKDLIKGMLNVDPS MAPKAPK3_Mmus IMYILLCGFPPFYSNTGQAISPGMKRRIRLGQYSFPNPEWLDVSEDAKQLIRLLLKTDPT MAPKAPK2_Mmus IMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPT K08F8.1_Cele AMYILLCGYPPFYSMKGVALSPGMRSRIANAYYAFPHEEWDCVSKDTKDDIRCLLRTNPS C44C8.6_Cele IMYILLCGYPPFYSQHGQPMSPGMKAKIKSGQYTFPSPEWDCVSEAAKDLIRKLLRTEPT MAPKAPK2_Spur IMYILLCGFPPFYSNHGMAISPGMKRRIRNGQYEFPDPEWSQVSEDAKNLIKKLLRTDPA MAPKAPK5a_Spur ------------------------------------------------------------ AqueK073_Aque ITYILLCGFPPFYSYGGAPISPGMKKRIRQGQYGFPDPEWTNVSSQAKDLIKGLLKTNPA MAPKAPK3_Hsap ERLTITQFMNHPWINQSMVVPQTPLHTARVLQED-------------------------- MAPKAPK2_Hsap QRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED-------------------------- MAPk-Ak2_Dmel KRLRIQDVISNKWIAQYNAVPQTPLCTGRMLKEA-------------------------- MAPKAPK3_Mmus ERLTIMQFMNHPWINQSMVVPQTPLYTARVLQED-------------------------- MAPKAPK2_Mmus QRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKED-------------------------- K08F8.1_Cele DRLTIHELMATPLVTGEPIVPGKHITTAIAIPGADESECGGGVFDDGFIVEEEETPDTVA C44C8.6_Cele ERITIEQTMEHKWISHYRRVPDTPLFTSSNLNDQ-------------------------- MAPKAPK2_Spur ERLSIQEFMNSPWVRQCSAVPATPLHTSSVMKEE-------------------------- MAPKAPK5a_Spur ----------------------TPIA---------------------------------- AqueK073_Aque DRFTIDDVLRHRWIAGYQEVPQTPLACIQVLQDD-------------------------- . : MAPKAPK3_Hsap -----------------KDHWDEVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRK MAPKAPK2_Hsap -----------------KERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRK MAPk-Ak2_Dmel -----------------EETWPEVQEEMTRSLATMRVDYDQMQIKALDKSNNPLLTKRRK MAPKAPK3_Mmus -----------------KDHWDDVKEEMTSALATMRVDYDQVKIKDLKTSNNRLLNKRRK MAPKAPK2_Mmus -----------------KERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRK K08F8.1_Cele EILPVPKSVRFLRDGVKAPRLHSIQEEVGRAMEIMRMGTDQVYIKNPTASCNNLFERRRA C44C8.6_Cele -----------------REQWTDMQDEMEATLASMRVGPENIQIKSLGDSNNKLLAKRRK MAPKAPK2_Spur --------------G--VNQWADIQDEMTNALATMRVDYDQIKIKEVNVSTNPLLAKRRK MAPKAPK5a_Spur ------------------------------------------------------------ AqueK073_Aque -----------------KELWPDIQDEMSHALATMRVADEPSKIKKVADANNPILARRAK MAPKAPK3_Hsap KQAGSSSA------------SQGCNNQ MAPKAPK2_Hsap KARALEAA---------------ALAH MAPk-Ak2_Dmel KIEEMELY------------MANATRN MAPKAPK3_Mmus KQAGSSSA------------SQGCNNQ MAPKAPK2_Mmus KARAVEDA---------------ALAH K08F8.1_Cele VHLSI-----------------PRVYC C44C8.6_Cele GGASPKDDPMDDIKEEEKDDEEEKMIS MAPKAPK2_Spur KELAM-------------------QAE MAPKAPK5a_Spur -------------------QLEYKLHF AqueK073_Aque KNS----------------------GK