CLUSTAL W (1.83) multiple sequence alignment MLK4_Hsap MALRGAAGAT--D-----TPV--------------------------------------- MLK3_Hsap MEPLKSLF-L--K-----SPL---G----------------------------------- MLK2_Hsap MEEEEG------------------------------------------------------ MLK1_Hsap MEPSRALL-G---------CL---A----------------------------------- slpr_Dmel MLPISEEQQL--QQQ--------------------------------------------- MLK4_Mmus MALPVAEGTA--D-----TPL--------------------------------------- MLK3_Mmus MEPLKNLF-L--K-----SPL---G----------------------------------- MLK2_Mmus MEEEEG------------------------------------------------------ MLK1_Mmus MESSRSLL-G---------CL---A----------------------------------- K11D12.10_Cele MEQASVPSYV--NI----PPI---A----------------------------------- MLK_Spur MDTKKKKKKK--K-----KKK---K-KKKKKKKKKKKEKKNEKQKKKKKKKKKKKKKKKK AqueK658_Aque MEVQKRLKA----------SI---G----------------------------------- AqueK659_Aque MANTVSGEEEHLSSTTIIIPSTPDPKANYPG------------------NHLVTNSSS-- * MLK4_Hsap ------------S-SA---------GGAP-GGS-A-------SSSSTS------------ MLK3_Hsap ----S---WN-GSGSG--------GGGGG-GGGR--------PE-GS------------- MLK2_Hsap ------------------------------------------------AV-A-------- MLK1_Hsap ----S---AAAAAPPG--------EDGAG-AGAEE-------EEEEEEEA-A-------- slpr_Dmel --------------------------------------------QQQQQLEQLHHPQIPE MLK4_Mmus ------------S--------------------------------PAR------------ MLK3_Mmus ----S---WN-GSGSG--------GGGGT-GGVR--------PE-GS------------- MLK2_Mmus ------------------------------------------------AA-A-------- MLK1_Mmus ----S---AT-AAPPG--------DDATG-AGAEE-------EE-DEEEA-A-------- K11D12.10_Cele ----KTRSTSHLAPTPEHHRSVSYEDTTT-ASTSTDSVPEVRIRSESSQV-S-------- MLK_Spur EEEEK---KK-KKKTG--------GGQVSLTRTLS-------GGSESTNH-S-------- AqueK658_Aque ------------------------------------------------------------ AqueK659_Aque ----G---NNATTPMM--------DPGNG-PGLFP-------SVTPSQSLTTVATAEVPE MLK4_Hsap ----------S-------GGSASAGAGLWAALYDYEARGEDELSLRRGQLVEVLSQDAAV MLK3_Hsap ----------P-------KA-AGYANPVWTALFDYEPSGQDELALRKGDRVEVLSRDAAI MLK2_Hsap ----------K-------EWGTTPAGPVWTAVFDYEAAGDEELTLRRGDRVQVLSQDCAV MLK1_Hsap ----------AAVG--PGELGCDAPLPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQV slpr_Dmel IPIP----------DLEQVETQVGDGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEV MLK4_Mmus ----------D-------DS-GSTSSGMWAALYDYEARGEDELSLRRGQLVEVLSQDAAV MLK3_Mmus ----------P-------KATAAYANPVWTALFDYEPNGQDELALRKGDRVEVLSRDAAI MLK2_Mmus ----------R-------EWGATPAGPVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAV MLK1_Mmus ----------A-------ELGSHAALPYWTAVFEYEAAGEDELTLRLGDVVEVLSKDSQV K11D12.10_Cele ----------R-------ESPPIRASKAFVASYEYEAQKDDELNLPLGAIITLVTVE--- MLK_Spur ----------L-------NHGVLPVTSLCTAMHDYESTADDELTIHRGDLVEIISKDHAV AqueK658_Aque ------------------------------------------------------------ AqueK659_Aque GQLNKAFKRTRSLGGSDGSKKSPGVKNIGIVIGDFKGLYPDEITLTVGERIEILSKDMIV MLK4_Hsap SGDEGWWAGQVQ-RRLGIFPANYVAPCRPAASPAP----PP--SRPS-SPVHVAFERLEL MLK3_Hsap SGDEGWWAGQVG-GQVGIFPSNYVSRGGGP--------------PPCE---VASFQELRL MLK2_Hsap SGDEGWWTGQLPSGRVGVFPSNYVAPGAPAA---------P---AGLQLPQEIPFHELQL MLK1_Hsap SGDEGWWTGQLN-QRVGIFPSNYVTPRSAFSSRCQPGGEDPSCYPPIQ-LLEIDFAELTL slpr_Dmel SGDVGWWTGKIG-DKVGVFPKDFVTDEDPLQLNVS----SA--IGDI-QPHEIEYNELDI MLK4_Mmus SGDEGWWAGQVQ-RRLGIFPASYVAPCGPVPPPAP----PP--PRPC-SPVHVDFERLEL MLK3_Mmus SGDEGWWAGQVG-GQVGIFPSNYVSRGGGP--------------PPCE---VASFQELRL MLK2_Mmus SGDEGWWTGQLPSGRVGVFPSNYVAPAAPAA---------P---SDLQLPQEIPFHELQL MLK1_Mmus SGDEGWWTGQLN-QRVGIFPSNYVTPRSAFSSRCQPGAEDPSCYPPIQ-LLEIDFAELTL K11D12.10_Cele TNEDGWYRGELN-GKVGLFPSNYAREVTYKDNLVE-FKQD-----EIMLP----VAVRTL MLK_Spur SGDDGWWMGKVG-DQQGIFPNNYVSDSQFIL---------E-KEINY-GVNEIDFNEIQL AqueK658_Aque -------------------------------------------------PY-LLEDAVEI AqueK659_Aque SRNIGWWAGRNSKGTVGIFPAASVKVVSQLEAQSD-----D--TDFE-YPLEIPADDIKL : MLK4_Hsap K-ELIGAGGFGQVYRATWQ--------------GQEVAVKA------ARQDP--EQDA-- MLK3_Hsap E-EVIGIGGFGKVYRGSWR--------------GELVAVKA------ARQDP--DEDI-- MLK2_Hsap E-EIIGVGGFGKVYRALWR--------------GEEVAVKA------ARLDP--EKDP-- MLK1_Hsap E-EIIGIGGFGKVYRAFWI--------------GDEVAVKA------ARHDP--DEDI-- slpr_Dmel K-EVIGSGGFCKVHRGYYD--------------GEEVAIKI------AHQTG--EDDM-- MLK4_Mmus K-ELIGAGGFGQVYRATWQ--------------GQEVAVKA------ARRDP--EQDA-- MLK3_Mmus E-EVIGIGGFGKVYRGSWR--------------GELVAVKA------ARQDP--DEDI-- MLK2_Mmus E-EIIGVGGFGKVYRAVWR--------------GEEVAVKA------ARLDP--ERDP-- MLK1_Mmus E-EIIGIGGFGKVYRAFWA--------------GDEVAVKA------ARHDP--DEDI-- K11D12.10_Cele SDCQIGHGATATVFKMDIKIKKELQNGRMGEAVGDQM--K-AALKRFNRHASNFRADVVS MLK_Spur N-ELIGVGGFGKVFRGSWR--------------GEEVAVKA------AKHDP--EEDD-N AqueK658_Aque G-EAIEKGAYSSTVRVRWQ--------------GTEYRGNKLHDVH-LRLEK--KKG--- AqueK659_Aque G-DVIGLGGFGKVYRAQYK--------------GEDVAVKV------ARHTT--Y-DT-- * *. . : * : : . MLK4_Hsap -AAAAESVRREARLFAMLRHPNIIELRGVCLQQP---HLCLVLEFARGGALNRAL-AAAN MLK3_Hsap -SVTAESVRQEARLFAMLAHPNIIALKAVCLEEP---NLCLVMEYAAGGPLSRAL-AG-- MLK2_Hsap -AVTAEQVCQEARLFGALQHPNIIALRGACLNPP---HLCLVMEYARGGALSRVL-AG-- MLK1_Hsap -SQTIENVRQEAKLFAMLKHPNIIALRGVCLKEP---NLCLVMEFARGGPLNRVL-SG-- slpr_Dmel -QRMRDNVLQEAKLFWALKHENIAALRGVCLNT----KLCLVMEYARGGSLNRIL-AG-- MLK4_Mmus -AAAAESVRREARLFAMLRHPNIIQLRGVCLRQP---HLCLVLEFARGGALNRAL-AAAA MLK3_Mmus -SVTAESVRQEARLFAMLAHPNIIALKAVCLEEP---NLCLVMEYAAGGPLSRAL-AG-- MLK2_Mmus -AVTAEQVRQEARLFGALQHPNIIALRGACLSPP---NLCLVMEYARGGALSRVL-AG-- MLK1_Mmus -SQTIENVRQEAKLFAMLKHPNIIALRGVCLKEP---NLCLVMEFARGGPLNRVL-SG-- K11D12.10_Cele TDEQLEQLKREANLVNGLSHNNIVRLLGICLEDP---YFGLLLELCEGSSLRNVC-RNLN MLK_Spur VRSTIDNVRQEAKLFSLLSHPNIISLRGACLREP---HVCIVMEYARGGSLNRLL-FG-- AqueK658_Aque GEELLGRLRRHCELVFSLNHPNLVQHIGVALSTQDGPAPILITPSL-PTNLANIISAN-- AqueK659_Aque -MKAVSDVLSEAEKFAHLAHENVCALIGVCLVK----DVCLVMEYAKGGPLSKIL-HE-- : ... . * * *: . .* :: * . MLK4_Hsap AAPDPRAPGPRRARR--IPPHVLVNWAVQIARGMLYLHEEAFVPILHRDLKSSNILLLEK MLK3_Hsap -------------RR--VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQP MLK2_Hsap -------------RR--VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEA MLK1_Hsap -------------KR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQK slpr_Dmel --------------KI--PPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEA MLK4_Mmus S--DPRAPGPRRARR--IPPQVLVNWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEK MLK3_Mmus -------------RR--VPPHVLVNWAVQIARGMHYLHCEALVPVIHRDLKSNNILLLQP MLK2_Mmus -------------RR--VPPHVLVNWAVQVARGMNYLHNDAPVPIIHRDLKSINILILEA MLK1_Mmus -------------KR--IPPDILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQK K11D12.10_Cele -----------SDAA--IPLGVLIDWATQVAEGMEYLTKQG---YVHRDLKADNVLVKEE MLK_Spur -------------KKMAMPPNVLVNWAYQIADGMNYLHWEAPIPLIHRDLKSSNILLDQK AqueK658_Aque -------------TR--LPPAVSHSILRDVSQGLAYLHNRPKAPVPHGSLSANNVLLTRG AqueK659_Aque -------------RNITLTVDIILDWSRQITEGMEYLHHEITPSLIHRDLKSSNILLQYE . : . ::: *: ** * .*.: *:*: MLK4_Hsap IE-----------------HDDICNKTLKITDFGLAREWH-RTTKMSTA----------- MLK3_Hsap IE-----------------SDDMEHKTLKITDFGLAREWH-KTTQMSAA----------- MLK2_Hsap IE-----------------NHNLADTVLKITDFGLAREWH-KTTKMSAA----------- MLK1_Hsap VE-----------------NGDLSNKILKITDFGLAREWH-RTTKMSAA----------- slpr_Dmel IE-----------------GNHLQQKTLKITDFGLAREMY-NTQRMSAA----------- MLK4_Mmus IE-----------------HDDICNKTLKITDFGLAREWH-RTTRMSAA----------- MLK3_Mmus IE-----------------GDDMEHKTLKITDFGLAREWH-KTTQMSAA----------- MLK2_Mmus IE-----------------NHNLADTVLKITDFGLAREWH-KTTKMSAA----------- MLK1_Mmus VE-----------------NGDLSNKILKITDFGLAREWH-RTTKMSAA----------- K11D12.10_Cele VCLCMDEEMFQYAYCLKCGKRPFDKLQLKITDFGVTRKMTADANRFSTA----------- MLK_Spur VE-----------------HSNMYNIQLKITDFGLAREMY-KTTRMSAA----------- AqueK658_Aque LE-----------------A--------KLSNLGVAAILE-SGSGGGSKGAAIIAHTKTP AqueK659_Aque VN-----------------PADLKGNLIKITDFGLAREIE-NTTHLSGA----------- : *::::*:: . MLK4_Hsap --GTYAWMAPEVIKSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTL MLK3_Hsap --GTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTL MLK2_Hsap --GTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTL MLK1_Hsap --GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLAL slpr_Dmel --GTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTL MLK4_Mmus --GTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTL MLK3_Mmus --GTYAWMAPEVIKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTL MLK2_Mmus --GTYAWMAPEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTL MLK1_Mmus --GTYAWMAPEVIRASMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAMNKLAL K11D12.10_Cele --GTYAWLAPEAFKEGTWSEASDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQNL MLK_Spur --GTYAWMAPEVIKSSLFSKSSDVWSFGILLWELLTGEVPYKGIDTLAVAYGIAVNKLTL AqueK658_Aque EQTCYA-PPPE---EQPLTMAGDVFSFGVLVLHILSGKYPIPTGEGKKEI-----ERRGM AqueK659_Aque --GTYPWMAPEVIKSSEFSKKSDVWSFGVVLWEILTGEKPYSGLDMFVVAYGVGHGTLTL *. .** : .*::*:*::: .::: : * : MLK4_Hsap PIPSTCPE--PFAKLMKECWQQDPHIRPSFALILEQLTAIEGA----VMTEM----PQES MLK3_Hsap PIPSTCPE--PFAQLMADCWAQDPHRRPDFASILQQLEALEAQ----VLREM----PRDS MLK2_Hsap PIPSTCPE--PFARLLEECWDPDPHGRPDFGSILKRLEVIEQS----ALFQM----PLES MLK1_Hsap PIPSTCPE--PFAKLMEDCWNPDPHSRPSFTNILDQLTTIEES----GFFEM----PKDS slpr_Dmel PIPKTCPE--TWGALMKSCWQTDPHKRPGFKEILKQLESIACS----KFTLT----PQES MLK4_Mmus PIPSTCPE--PFAKLMKECWEQDPHIRPSFALILQQLTAIEEA----VLTNM----PQES MLK3_Mmus PIPSTCPE--PFAQLMADCWAQDPHRRPDFASILQQLEALEAQ----VLREM----PRDS MLK2_Mmus PIPSTCPE--PFARLLEECWDPDPHGRPDFGSILKQLEVIEQS----ALFQM----PLES MLK1_Mmus PIPSTCPE--PFAKLMEDCWNPDPHSRPSFTSILDQLTTIEES----GFFEM----PKDS K11D12.10_Cele SIGDSCPD--RWKKLMQDCWNLEPNFRPKFSTLAISFKQYAKEFKDTHLQRAPSKMAVKE MLK_Spur PIPSTCPE--IFSKMLLDCWNYDPHERPTFSEIMQQLKDISES----PFINT----PQDS AqueK658_Aque Y-ISQIPEKNNLLPLVKECLQNDPAQRPLALTLVERLTRFSSEQ--PLPFQT----SLEL AqueK659_Aque PIPEHCPL--SLRDLMSCCWKREHSKRPSFTQVKEKLVEIQKT----EFLYT----SDEE . * :: * : ** : : . . MLK4_Hsap F--HSMQDDWKLEIQQMFDELRTKEKELRSREEELTRAALQQKSQEELLKRREQQLAERE MLK3_Hsap F--HSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWE MLK2_Hsap F--HSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAERE MLK1_Hsap F--HCLQDNWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAERE slpr_Dmel F--HYMQECWRKEIAGVLHDLREKEKELRNKEEQLLRVQNEQREKANLLKIREQNLRERE MLK4_Mmus F--HSMQEDWKLEIQQMFSELRTKEKELRSREEELSRAALQQKSQELLLRRREQQLAERE MLK3_Mmus F--HSMQEGWKREIQGLFDELRAKEKELLSREEELTRAAREQRSQAEQLRRREHLLAQWE MLK2_Mmus F--HSLQEDWKLEIQHMFDDLRTKEKELRSREEELLRAAQEQRFQEEQLRRREQELAERE MLK1_Mmus F--HCLQDDWKHEIQEMFDQLRAKEKELRTWEEELTRAALQQKNQEELLRRREQELAERE K11D12.10_Cele LYSECFADKTKEEFEKRFHDLYAGSGDINRKNRHS------------------------- MLK_Spur F--HIMQQDWKEEIQEMFDELRVKEKELRTREDELSQAEIQQKLHAALLKRREQDLAERE AqueK658_Aque L--IT-MERREGELVTMVSQLRAGQEEVEGFGRRLSTYDEQLATIKEQMKKMEEEL---- AqueK659_Aque F--KSLQSTWKKEVKMKFNDLKKVESEVENKEKHLIQQMK---LQEERVIAMKKNLEEKE : . . *. . :* . :: . MLK4_Hsap ------IDVLERELNILIFQLN-QEKPKVKKRKGKFKRSRL-KLKDG-HRISLPSDFQHK MLK3_Hsap ------LEVFERELTLLLQQVD-RERPHVRRRRGTFKRSKL-RARDGGERISMPLDFKHR MLK2_Hsap ------MDIVERELHLLMCQLS-QEKPRVRKRKGNFKRSRLLKLREGGSHISLPSGFEHK MLK1_Hsap ------IDILERELNIIIHQLC-QEKPRVKKRKGKFRKSRL-KLKDG-NRISLPSDFQHK slpr_Dmel ------RVLIERELVMLQ-PVPS-KRKHKKGK------------KNKPLQISLPTGFRHT MLK4_Mmus ------IDVLERELNVLIFQLS-QEAPHVKKRKGRFRRGRL-RLKDG-HRISLPSDFQHK MLK3_Mmus ------LEVFERELTLLLQQVD-RERPHVRRRRGTFKRSKL-RARDGGERISMPLDFKHR MLK2_Mmus ------MDIVERELHLLMSQLS-QEKPRVRKRKGNFKRSRLLKLREGSSHISLPSGFEHK MLK1_Mmus ------IDILERELNIIIHQLC-QEKPRVKKRKGKFRKSRL-KLKDG-NRISLPSDFQHK K11D12.10_Cele ------------------------IAPETKARRLKHHK------PK-KADITGPTEVKHI MLK_Spur ------IELLERELNLVITQQQQDEKPVPKKRHGKIKANKL-R-RS-NKRISTPQDFHHK AqueK658_Aque ---VGG--------------LE-GKTPQA---------------------AAVNSLLQPP AqueK659_Aque QSLVDMMDKVQKQLEIIAREREK-RPPRTKKF---------------------------- MLK4_Hsap ITVQASPNLDK-----RRSLNSSSSSPPSSPTM---------------MPR--------- MLK3_Hsap ITVQASPGLDR-----RRNV--FEVGPGDSPT----------------FPR--------- MLK2_Hsap ITVQASPTLDK-----RKG--SDGASPPASPSI---------------IPR--------- MLK1_Hsap FTVQASPTMDK-----RKSLINSRSSPPASPTI---------------IPR--------- slpr_Dmel ITAVR-----------------DKAEQPGSPS----------------FSG--------- MLK4_Mmus ITVQASPTLDK-----RRSSDSGLCSPPGSPLM---------------LPR--------- MLK3_Mmus ITVQASPGLDR-----RRNV--FEVGAGDSPT----------------FPR--------- MLK2_Mmus ITVQASPTLDK-----RKG--SDGASPPASPSI---------------IPR--------- MLK1_Mmus FTVQASPTMDK-----RKSLISNRSSPPASPTI---------------IPR--------- K11D12.10_Cele LSVQKDDKNFRVKNDM--------SKTSRKIRLYVLHNSLQLTGKVLWIRRFLQVQTLPI MLK_Spur LTVKADPSFQRGGGDPRSSHLSPEESPPKSP-----------------IPR--------- AqueK658_Aque LELTTSN---------R-SGKNDKESSSGSPIL---------------KPT--------- AqueK659_Aque ------------------------------------------------FPR--------- MLK4_Hsap ---------------LRAIQLTSDES-----------NKTWGRNTVFRQEEFED-VKRNF MLK3_Hsap ---------------FRAIQLEPAEP-----------GQAWGRQSPRRLEDSSNGE---- MLK2_Hsap ---------------LRAIRLTPVDCGGSSSGSSSGGSGTWSRGGPPKKEELV-----GG MLK1_Hsap ---------------LRAIQLTPGES-----------SKTWGRSSVVPKEEGEEEEKRAP slpr_Dmel ---------------LRIVALTDGH----------------------------------- MLK4_Mmus ---------------LRAIQLTSDEN-----------NKTRGRNMVFRQEDFED-VKRSF MLK3_Mmus ---------------FRAIQLEPTES-----------GQTWGRQSPRRLEDSSNGE---- MLK2_Mmus ---------------LRAIRLTPMDCGGS------SGSGTWSRSGPPKKEELV-----GG MLK1_Mmus ---------------LRAIQLTPGES-----------SKTWGRSSVVPKEEGEEEEKRAP K11D12.10_Cele QSIIFTQCLCLLDEQLQILHLTEHLA-----------MMLWCRIR--------------- MLK_Spur ---------------LRVFALPKEQ----------------------------------- AqueK658_Aque ---------------QSVF--------------------HWKRASPAP------------ AqueK659_Aque ---------------KM------------------------------------------- MLK4_Hsap KKKGCTWGPNSIQMKDRTD--------------CKER----------------------- MLK3_Hsap RRACWAWGPSSPKPGEAQN--------------GRRR----------------------- MLK2_Hsap KKKGRTWGPSSTLQKERVG--------------GEER----------------------- MLK1_Hsap KKKGRTWGPGTLGQKELAS--------------GDEGSPQRREKANGLSTPSESPHFHLG slpr_Dmel --KGKTWGPSTMHQRERSL--------------LPSQLS------GG----------QPE MLK4_Mmus KKKGCTWGPSSVQTKERPE--------------GRER----------------------- MLK3_Mmus RRACWAWGPSSPKPGEAQN--------------GRRR----------------------- MLK2_Mmus KKKGRTWGPSSTLQKERAG--------------GEER----------------------- MLK1_Mmus KKKGRTWGPGTLGQKELTS--------------GDEGSPQRREKANGLSTPSESPHFHLG K11D12.10_Cele --------------MELAMGIKIILYVKYFRSILNQ-----KSMA--------------- MLK_Spur -PKGKTWGPSTMQRKTRQK--------------TFR------------------------ AqueK658_Aque ------------------------------------------------------------ AqueK659_Aque ----LEWLTMSSR----------------------------------------------- MLK4_Hsap IRPLSDGNSPWSTI---LI--KNQKTMP---LASLF---VDQPGSCE------------- MLK3_Hsap SR-MDEATWYLDSDDSSPL--GSPSTPP---ALNGN------------------------ MLK2_Hsap LKGLGEGSKQWSSSAPNLG--KSPKHTP---IAPGF---ASLN-EME------------- MLK1_Hsap LKSLVDGYKQWSSSAPNLV--KGPRSSP---ALPGF---TSLM-EMALLAASWVVPIDIE slpr_Dmel WPAQTSTHSSFSKSAPNLD--KKQQQQNQQQVASL----TPPPG-LGILGGSGGAGGTPA MLK4_Mmus VRPLSDGNSPWSSL---LI--KSQKTTP---LASLF---VDQPGSCE------------- MLK3_Mmus SR-MDEATWYLDSDDSSPL--GSPSTPP---ALNGN------------------------ MLK2_Mmus LKALGEGSKQWSSSAPNLG--KSPKHTP---MAPGF---ASLN-EME------------- MLK1_Mmus LKSLVDGYKQWSSSAPNLG--KGPRSSP---ALPGF---TSLM-EI-------------- K11D12.10_Cele ---VLNKPAGLSDTIPLFP--EEPTHYD---MGPGRPFGTNGR-AIV------------- MLK_Spur PHTLSEATAKKFTSAPNLIHGKSP-LSP---MLDGN---WQV------------------ AqueK658_Aque ---------------------------------VGM---H-------------------- AqueK659_Aque ------------------------------------------------------------ MLK4_Hsap E----------PKLSPDGLEHRKPKQIKLPSQAY---------------IDLPLGKDAQR MLK3_Hsap ------------------------------------------------------PP---- MLK2_Hsap E----------FAEAEDGGSSVPPSPYSTP--SY---------------LSVPLPA---- MLK1_Hsap E----------DED-SEGPGSGESRLQHSPSQSY---------------LCIPFPRGEDG slpr_Dmel T----------PLLYPAKIYHRARSQEY-----G---------------LDHPLAY---- MLK4_Mmus E----------QKLVPEGLEHRKPKQTKFPGQAH---------------VGLPLCKDSQR MLK3_Mmus ------------------------------------------------------PP---- MLK2_Mmus E----------FAEADE-GNNVPPSPYSTP--SY---------------LKVPLPA---- MLK1_Mmus E----------DED-SEGPGSGENHQQHSPNQSY---------------LCIPFPRGEDG K11D12.10_Cele NQGGDYYGNISGQN-YEGFGHGRSINQS--TQYYPVGGGCDDYIPIVQKTVIKPTVGEVG MLK_Spur -------------------------SLANPKPNW---------------LDVG--P---- AqueK658_Aque ----------------------SASAIVLEGKLY---------------IGGGMTKDLQS AqueK659_Aque ------------------------------------------------------------ MLK4_Hsap ENPAEAESWEEAASANAATVS-----IEMTPTNSL-SRSPQRKKTESALYGCTVLLASV- MLK3_Hsap ----------RPSLE---PEEPK----RPVPAERG-SSSGTPKLIQRALLRGTALLASL- MLK2_Hsap ----------EPSPGARAPWEPT---PSAPPA---RWGHGARRRCDLALLGCATLLGAV- MLK1_Hsap DGPSSDGIHEEPTPVNSATST-----PQLTPTNSLKRGGAHHRRCEVALLGCGAVLAAT- slpr_Dmel ----------QPPPLYLVTDDSSETDTVASPTGC---FHFLKSGNSS-AASGAVHLHRFG MLK4_Mmus EDSSEAESREEGS-------------PKGSPVNNV-GAPMLRKKTESALCECGMLLASM- MLK3_Mmus ----------RPSPE---PEEPR----RAGPTERG-NSSGTPKLIQRALLRGTALLASL- MLK2_Mmus ----------EPSPCVQAPWEP----PAVTPS---RPGHGARRRCDLALLSCATLLSAV- MLK1_Mmus DGPSSDGVHEEPTPVNSATST-----PQLTPTNSLKRGGTHHRRCEVALLGCGAVLAAT- K11D12.10_Cele NSPYSENIRCATR----------------------------------------------- MLK_Spur ----------TPDHEDEDTHDPK----R----DSLRRKSSKPGMAETGLYGAAAILASV- AqueK658_Aque DRILYEY--DISGMVHK--WTA-------LP------------TCPIAYFSMGVVNKT-- AqueK659_Aque ------------------------------------------------------------ MLK4_Hsap -ALGLDLRELHKAQA-----A-EEPLP---------------KEEKKKREGI-FQRASKS MLK3_Hsap -GLGRDLQPPGGPGRERGES---------------------------------------- MLK2_Hsap -GLGADVAEARAAD------------G---------------EEQRRWLDGLFFPRAGRF MLK1_Hsap -GLGFDLLEAGKCQLLPLEEP-EPP-A---------------REEKKRREGL-FQRSSRP slpr_Dmel GSLGNSPAVGRKKH--SLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHA-FYRDVIK MLK4_Mmus -ALGLDVRKLHGAQA-----P-AKPSP----------------KMEKKEEGA-LQPASRC MLK3_Mmus -GLGRDLQPPGGLSRERGES---------------------------------------- MLK2_Mmus -GLGADVAEARAGD------------G---------------EEQRRWLDSLFFPRPGRF MLK1_Mmus -GLGFDLLEAGKCQLLPPEEP-EPP-A---------------REEKKRREGL-FQRASRP K11D12.10_Cele -----NV---------------QNPQY---------------IQCK---------KNQNP MLK_Spur -ALGYDVRTTNLAIY-----Q----SG---------------ELEHRRKEY-A-KQASAD AqueK658_Aque ------LVLVGGLEIMTRK--TSNKLF---------------MWDKERQEW--------- AqueK659_Aque ------------------------------------------------------------ MLK4_Hsap RRSASPPTSLPSTCGEASSPPSLPLSSALGILS-----------------------T--- MLK3_Hsap -----P------------------------------------------------------ MLK2_Hsap PRGLSPPARPHGRREDVGPGLGL--APSATLVS-----------------------L--- MLK1_Hsap RRSTSPPSRKLFKKEEPMLLLGDP-SASLTLLS-----------------------L--- slpr_Dmel KMS---------------------MASSERVNS-----------------------K--- MLK4_Mmus QSSPSSLLRQPSAGRAPSGGSTLLLPSAPSHSS-----------------------K--- MLK3_Mmus -----P------------------------------------------------------ MLK2_Mmus PRGLSPTGRPGGRREDTAPGLGL--APSATLVS-----------------------L--- MLK1_Mmus RRSTSPPSRKLFKKEEPMTLLGDP-SASLTLLS-----------------------L--- K11D12.10_Cele RRIPAL------------------------------------------------------ MLK_Spur EVSTQTSDNDMNGLEDEDYLSISS-TANLTKNW-----------------------VAAP AqueK658_Aque --CNTLPSMNVS-RQNPCVA-----SHNLSLIVAGGYRNKQVLADVEVFDQATFQWISFP AqueK659_Aque ------------------------------------------------------------ MLK4_Hsap -----PS----FSTKCLLQMDSEDPLVDSAP---VTCDSEM---LTPDFCPTAPGSG--- MLK3_Hsap ---------------------------T-T-----------------PPTPTPAPCP--- MLK2_Hsap -----SSVSDCNSTRSLLRSDSDEAAPA-AP--------------SPPPSPPAPTPT--- MLK1_Hsap -----SSISECNSTRSLLRSDSDEIVVY-----------------EMPVSPVEAPPL--- slpr_Dmel -SS--GDLTMYNSSTPLTARDCDDAEEA-FEGGRFQPDADADDECQVPASQMRQNSTTSR MLK4_Mmus -----SS----LSMKCLLQAGKEESSLGNAR---DLCGPTT---LTPDPGSAAPESGCE- MLK3_Mmus ---------------------------T-A----------------PPPAQMPSPCP--- MLK2_Mmus -----SSVSDCNSTRSLLRSDSDEAAPA-AP--------------SPPPSPLA------- MLK1_Mmus -----SSISECNSTRSLLRSDSDEIVVY-----------------EMPVSPVEAPPL--- K11D12.10_Cele ------------------------------------------------------------ MLK_Spur PST--GMWNDTNATNN-----------H-QP---------------PPPTQL-------- AqueK658_Aque PLLVPTSCASCCVVRDILYIL--------------------------------------- AqueK659_Aque ------------------------------------------------------------ MLK4_Hsap REPALMPRLDTDCSVSRNLPSSFL-QQTCGNVPYCASSKHRPSHHRRTMSDGNPTPTG-A MLK3_Hsap TEPPPSPLICFSLK--TPD--SPP-TPAPLLL----D-LGIPVGQRSAKSP-----RRE- MLK2_Hsap PSPSTNPLVDLELESFKKDPRQSL-TPTHVTA----A-CAVSRGHRRTPSDGALGQRGPP MLK1_Hsap SPCTHNPLVNVRVERFKRDPNQSL-TPTHVTL----TTPSQPSSHRRTPSDGALKPE--- slpr_Dmel KSSVTFQSVSFEEP---------------------------------------------- MLK4_Mmus LIPGLRPKT--DYGVLRSMPHAIL-EQTGERLPGCAIVGDKGCHHMQMGSEETP-----L MLK3_Mmus PELPSTPLIRLSQT--TPDAHSSP-TPGPLLL----D-LGVPSGQPSAKSP-----RRE- MLK2_Mmus PSPSTNPLVDVELESFKKDPRQSL-TPTHVTA----A-HAVSRGHRRTPSDGALRQREPL MLK1_Mmus TQCTHNPLVNVRVERFKRDPNQSL-TPTHVTL----TAPTQPSGHRRTPSDGALKPTAAP K11D12.10_Cele --------------------------PMKIQS----ESNLVTSGMVFTPRDEQLNGIG-N MLK_Spur -LVKQNPAYLDHRDSLPNDEQPLPTVRTHRRTASAD-DNLNSMRRTRTPSDSSTPSTK-- AqueK658_Aque ------------------------------------------------------------ AqueK659_Aque ------------------------------------------------------------ MLK4_Hsap TIISATGASALPLCPSPA--------PHSHLPREVSPKK--------------------- MLK3_Hsap -----EEPRGGTVSPPPGT-----------------------------SRSA---PGTPG MLK2_Hsap -EPAGH-------GPGP-----------RDLLDFPRLPDPQALFPA--RRRP---PEFPG MLK1_Hsap TLLASRSPSSNGLSPSPGAGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLE slpr_Dmel ------------------------------------------------------------ MLK4_Mmus WLQSAPEDSGLPHSPSPG--------PQRDLASQASLVKPEGVLGE-------------- MLK3_Mmus ------ETRGRTVSPPPGI-----------------------------SRSA---PGTPG MLK2_Mmus -ELTNH---------GP-----------RDPLDFPRLPDPQALFPT--RRRP---LEFPG MLK1_Mmus AVLGSRSPSSNGMSPSPGTGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQRDSTLE K11D12.10_Cele -SLSSL--------------------SLNEPPDIPAPLPPVVT----------------- MLK_Spur --WDSTG--DQWSTCSPGSD---VSSPFRSPPQV----------P--PRRTSFVGDSQME AqueK658_Aque ---------GGSLYGEGGASNV------------------------------VQ--TIPL AqueK659_Aque ------------------------------------------------------------ MLK4_Hsap ---HSTVHIVP-QRRPASLRSRSDL----------------------PQAYPQTA----- MLK3_Hsap TPRSPPLGLIS-RPRPSPLRSRIDPWSFVS---------AGPRPSPLPSPQPAPR----- MLK2_Hsap --RPTTLTFAP-RPRPAASRPRLDPWKLVS---------FGRTLTISPPSRPD------- MLK1_Hsap --RPKTLEFLP-RPRPSANRQRLDPWWFVS---------PSHARSTSPANSSSTE----- slpr_Dmel -------DFVA-TPRTTARSDLYTSSASIS---------FATYRSASPSLSSSSTTASAS MLK4_Mmus ---CQACPALPQRPHTASVRTTSPP------------------------TWVCDK----- MLK3_Mmus TPRSPPLGLIS-RPRPSPLRSRIDPWSFVS---------AGPRPSPLPSPQPAPR----- MLK2_Mmus --RPTTLTFAP-RPRPAASRPRLDPWKLVS---------FGRTLSISPPSRPD------- MLK1_Mmus --RPKTLEFLP-RPRPSANRQRLDPWWFVS---------PSHARSASPANSSSTE----- K11D12.10_Cele ------------YPI---------PASLIS---------PSNRVSMSPPTRMA------- MLK_Spur --RPSSLDICA-RPRPHS-RVYLTPQNQSSNESPHRRVSSSANTTPRHSYHADSS----- AqueK658_Aque TGDPSSV-----------------GWSLVQ---------NAPLTK-----------SYAV AqueK659_Aque ----------------------------------------EQRR---------------- MLK4_Hsap ------------------------------------------------------------ MLK3_Hsap ------------------------------------------------------------ MLK2_Hsap ------------------------------------------------------------ MLK1_Hsap ------------------------------------------------------------ slpr_Dmel PSIASTEAVNGYHMQENSILNTRRMQDVQPHPDVIKLRAQEQRQQTKNQKKQRPKHITKS MLK4_Mmus ------------------------------------------------------------ MLK3_Mmus ------------------------------------------------------------ MLK2_Mmus ------------------------------------------------------------ MLK1_Mmus ------------------------------------------------------------ K11D12.10_Cele ------------------------------------------------------------ MLK_Spur ------------------------------------------------------------ AqueK658_Aque PSSNFLLAVGGAM----------------------------------------------- AqueK659_Aque ------------------------------------------------------------ MLK4_Hsap --------------------------------V------SQLAQTAC-VVGRP----GPH MLK3_Hsap --------------------------------RAPWT---LFPDSDPFWD-S------PP MLK2_Hsap ---------------------------------TP---------------ESP----GPP MLK1_Hsap ---------------------------------TPSNLDSCFASSSSTVEERP----GLP slpr_Dmel KSVEAPVEGQHHEHDDHNDPQHQHHSAGSSKIRALFN---LFTRSRKKYS-KLAE----- MLK4_Mmus --------------------------------D----------------HQVP----AL- MLK3_Mmus --------------------------------RAPWT---LFPDSDPFWD-S------PP MLK2_Mmus ---------------------------------TP---------------ESP----GPP MLK1_Mmus ---------------------------------TPSNLDSCFASSSSTVEERP----GLP K11D12.10_Cele -----------------------------------------------------------P MLK_Spur --------------------------------TA---SYSSHSSSNASGATSPPLSNTTP AqueK658_Aque -------------------------AGSNTPTRSVYV---YFPEMS-RWS-FLCE----- AqueK659_Aque ------------------------------------------------------------ MLK4_Hsap P-TQFLAAKER------------------------------------------------- MLK3_Hsap A-NPFQGGP--------------------------------------------------- MLK2_Hsap SV---------------------------------------------------------- MLK1_Hsap ALLPFQAGPL-------------------------------------------------- slpr_Dmel --HNMVGGPE-------------------------------------------------- MLK4_Mmus --ACLLGAQER------------------------------------------------- MLK3_Mmus A-NPFRGGS--------------------------------------------------- MLK2_Mmus SV---------------------------------------------------------- MLK1_Mmus ALLPLQAGPL-------------------------------------------------- K11D12.10_Cele V-LPL-GA---------------------------------------------------- MLK_Spur HHAPFQHSFSQPQTTQQVQKYQHQHQQQQQPYQQQSHVYNAHYQQQSQVSHHQSSQHQAT AqueK658_Aque --MPTAHAKC-------------------------------------------------- AqueK659_Aque ------------------------------------------------------------ MLK4_Hsap ---------------------------------TKSHVPSLLDADVEGQSRDYT-VPLCR MLK3_Hsap -------------------------------------------QDCRAQTKDMG-A---- MLK2_Hsap -------------------------------------QPTLLDMDMEGQNQDST-VPLCG MLK1_Hsap ----------------------------------PPTERTLLDLDAEGQSQDST-VPLCR slpr_Dmel ---------------------------------FCAIDPYQTDLAMGGSSRSL------- MLK4_Mmus ---------------------------------SRCQTPSLLDASIEGQKKDCA-MPLCR MLK3_Mmus -------------------------------------------QDCRTQTKDMG-A---- MLK2_Mmus -------------------------------------QPTLLDMDMEGQSQDNT-VPLCG MLK1_Mmus ----------------------------------LPAERTLLDLDAEGQSQDST-VPLCR K11D12.10_Cele -----------------------------------MSSPRIMDKEILKN----------- MLK_Spur QQQQHHHHTTPTHQHQYQHHPQHQHHQQYHQGVLINNRPSLLDQDMEGQKRDPT-RTLEA AqueK658_Aque ---------------------------------IAAVLSAGRMIV-IGGNEEHAMKVEC- AqueK659_Aque ------------------------------------------------------------ MLK4_Hsap MRSKTSRPSIYELEKEFLS MLK3_Hsap --------Q-APWVPEAGP MLK2_Hsap A--------------HGSH MLK1_Hsap AELNTHRPAPYEIQQEFWS slpr_Dmel -KRKGKKPQTQSCEQLERC MLK4_Mmus VKSVMCQPSIYALEKDFLT MLK3_Mmus --------Q-APWAPEAGP MLK2_Mmus V--------------YGSH MLK1_Mmus AELNAHGPSPYEIQQEFWS K11D12.10_Cele ----------SSVEGTEIY MLK_Spur K--PTKEPSVNALIK-EFL AqueK658_Aque ----------GTTVELLSV AqueK659_Aque --AKATDNKLP-SKTIERK