CLUSTAL W (1.83) multiple sequence alignment MLKz_j_Smoe AMEVEL---ATID---THFYAS-L-LKSCG-----------------K------------ MLKz_e-2_Smoe MARENPSESAWL---GRCSFSRSVC-H-RIDARNIPDL-----------C---------- MLKz_c_Smoe MPFPISL------------V---------VLCVW-------------------------- MLKz_h_Smoe MTPQEQGKFVKLDVILDRQWSRTMSIGSIS-----------------G------------ MLKz_a-1_Smoe LPC--------------------------------------------------------- MLKz_a-2_Smoe MEVDGSE------------NG-----------------------CD-ANEAMDWAPHQQH MLKz_f_Smoe MGELSRY-----------RFSRSVC-H-RMDLLSLSRD----EEEGHGEES-----P-RS MLKz_d-2_Smoe MEALNGNFYGFT---ADDYYERLAA-G--SDNMSVDSVASLHTSNGGGSVT-----MTAA MLKz_e-1_Smoe MARENPSESAWL---GRCSFSRSVC-H-RIDARNIPDL-----------C---------- MLKz_g-2_Smoe MASEDDRY-----------FSRKEL-A--K-----------------G------------ MLKz_g-1_Smoe MASEDDRY-----------FSRKEL-A--K-----------------G------------ MLKz_d-1_Smoe MEALNGNFYGFT---ADDYYERLAA-G--SDNMSVDSVASLHTSNGGGSVT-----MTAA MLKz_b-1_Smoe MTSSQEF------------LEEEAV-A--VEGNIQEELRHRSHGSGGGEEA-----FSLH MLKz_b-2_Smoe MTSSQEF------------LEEEAV-A--VEGNIQEELRHRSHGSGGGEEA-----FSLH MLKz_j_Smoe ---------------------------------------------------TR-D----- MLKz_e-2_Smoe ------------------------------------------------------------ MLKz_c_Smoe ------------------------------------------------------------ MLKz_h_Smoe ---------------------------------------------------SR-K----- MLKz_a-1_Smoe -----------------------------------------RYASDVRKDRAQVVLIHKK MLKz_a-2_Smoe RNTKQEVLTEILQRLVEEGHEEASEPGFADELRAHFARLPTRYASDVRKDRAQVVLIHKK MLKz_f_Smoe KS---------------------------------------------------------- MLKz_d-2_Smoe ES---SVGS---------------------------------------NGSSRTILMHPE MLKz_e-1_Smoe ------------------------------------------------------------ MLKz_g-2_Smoe ---------------------------------------------------SR-V----- MLKz_g-1_Smoe ---------------------------------------------------SR-V----- MLKz_d-1_Smoe ES---SVGS---------------------------------------NGSSRTILMHPE MLKz_b-1_Smoe RATKAEVCQEIVKRLQAENHEALEDPGFLEELQAHFNRLPTRYALDVNTERAEDVLMHKR MLKz_b-2_Smoe RATKAEVCQEIVKRLQAQNHEALEDPGFLEELQAHFNRLPTRYALDVNTERAEDVLMHKR MLKz_j_Smoe ------------------------------------------------------------ MLKz_e-2_Smoe -------------------------------------------FPHQK-IGKPP-LRS-- MLKz_c_Smoe ----------------------------------------------------------QP MLKz_h_Smoe -----------------------------------------------------------F MLKz_a-1_Smoe MLEEAENPKNLPVLYVRAVSVRIACLSFL------------------------------- MLKz_a-2_Smoe MLEEAENPKNLPVLYVRAVSVRIACLPDASSMNSSPADSPSYS-PSSKADSHSPPAFE-- MLKz_f_Smoe ---------------------------------KMSSVAAAPAPPAPA-PGTPPPVRT-- MLKz_d-2_Smoe LG-------------------IKRG------NRSVTGSYSVVH-PST--VGA-------P MLKz_e-1_Smoe -------------------------------------------FPHQK-IGKPP-LRS-- MLKz_g-2_Smoe -----------------------------------------------------------L MLKz_g-1_Smoe -----------------------------------------------------------L MLKz_d-1_Smoe LG-------------------IKRG------NRSVTGSYSVVH-PST--VGA-------P MLKz_b-1_Smoe LLQLAENPDIRPVFHVRIVQVQQRL------DESVPGDQCMPV-PETQ-LVHPPPAFGSS MLKz_b-2_Smoe LLQLAENPDIRPVFHVRIVQVQQRL------DESVPGDQCMPV-PETQ-LVHPPPAFGSS MLKz_j_Smoe ------------------------------------------------------------ MLKz_e-2_Smoe RSHE-------------------------------------------------------- MLKz_c_Smoe EEL-------------------KQAV---------------------------------- MLKz_h_Smoe ------------------------------------------------------------ MLKz_a-1_Smoe ------------------LSV---------VNSFRV-------------SVGDMQMHEVT MLKz_a-2_Smoe -------GRLFTPTSSMCSTY---------VNTIRISIVDAIETLHCSPRIGDMQMHEVT MLKz_f_Smoe QSDR------------------RH------------------------------------ MLKz_d-2_Smoe PP-------------------TDEDVL--------------------------------- MLKz_e-1_Smoe RSHE-------------------------------------------------------- MLKz_g-2_Smoe PE-------------------IDESYL--------------------------------- MLKz_g-1_Smoe PE-------------------IDESYL--------------------------------- MLKz_d-1_Smoe PP-------------------TDEDVL--------------------------------- MLKz_b-1_Smoe PNLEALVLDLNKP-------SSDEDRESHADNSPSR-------------GLAQIFMHEVT MLKz_b-2_Smoe PNLEALVLDLNKP-------SSDEDRESHADNSPSR-------------GLAQIFMHEVT MLKz_j_Smoe ------------------------------------------------------------ MLKz_e-2_Smoe ------------------EIPLEISKKRLFIDSSSDYS---------------------- MLKz_c_Smoe ---------LTALSS--------------------------------------------- MLKz_h_Smoe ------------------------------------------------------------ MLKz_a-1_Smoe FSTVDKPKLLSKLSTILADVNLHVWEAHIFSTI-DGYSLDVFVVYGWHTEE--------- MLKz_a-2_Smoe FSTVDKPKLLSKLSTILADVNLHVWEAHIFSTI-DGYSLDVFVVYGWHTENIKDLEQALR MLKz_f_Smoe ------------------SLPKASYAKSLS----GPLP---------------------- MLKz_d-2_Smoe ------------------------------------------------------------ MLKz_e-1_Smoe ------------------EIPLEIFKKRLFIDSSSDYS---------------------- MLKz_g-2_Smoe ------------------------------------------------------------ MLKz_g-1_Smoe ------------------------------------------------------------ MLKz_d-1_Smoe ------------------------------------------------------------ MLKz_b-1_Smoe ISTIDKPKLLSQLSAWLADVGLNIQEAHAFSTR-DGFSLDVFVVDGWSCEDTEGLQLAME MLKz_b-2_Smoe ISTIDKPKLLSQLSAWLADVGLNIQEAHAFSTR-DGFSLDVFVVDGWSCEDTDGLQLAME MLKz_j_Smoe --------------------------------------LA-------------------E MLKz_e-2_Smoe -----------LP-------SSNRSSPFASPARTVEEFVHGNAPGRALVPKRVESWSQYL MLKz_c_Smoe --------------------------N-FT-ERARL------------------------ MLKz_h_Smoe ----------------------KEST----PA------AA-------------------A MLKz_a-1_Smoe --------GVWLR-------SSPSTSPSVSPSSSPDSIIA----------------PQAG MLKz_a-2_Smoe NSVACMEEGVWLR-------SSPSTSPSVSPSSSPDSIIA----------------PQAG MLKz_f_Smoe -----------VL-------GSDDG-KCSSPSAALPC--GEHQPKREL--RRLVSWSRYL MLKz_d-2_Smoe -------------------------------------T------------------NALM MLKz_e-1_Smoe -----------LP-------SSNRSSPFASPARTVEEFVHGNAPGRALVPKRVESWSQYL MLKz_g-2_Smoe -------------------------------------SIS----------------VDRL MLKz_g-1_Smoe -------------------------------------SIS----------------VDRL MLKz_d-1_Smoe -------------------------------------T------------------NALM MLKz_b-1_Smoe RALAGIEVLTRLNVLDTKTFSLLQKEAWTK-PKSPTKTLS----------------NGRR MLKz_b-2_Smoe RALAGIEVLTRLNFLDTKTFSLLQKEAWTK-PKSPTKSLS----------------NGRR MLKz_j_Smoe GKRAP------KPLQTIDMSKLVIREVIGLGAIGKVHRGTYNNEEVAIKLLDCSKPGLAG MLKz_e-2_Smoe EGIGEVKAVERSEEWVVDMTQLFLGHKFASGAHSRLYHGIYKGKAVAVKVMRQPEEDEEV MLKz_c_Smoe -R-EV-VESLAYEDWAVDYNNVRFSRLLGGGSSGRLYRGKYRGQDVAIKVIMLDEADGHS MLKz_h_Smoe AAGAP------KPLQTIDMSKLVIREVIGLGAIGKVHRGTYNNEEVAIKLLDCSKPGLAG MLKz_a-1_Smoe TNGWK-IPLDAPDDWEIDSSQLKRIKKILPSSNGDIYRGTFCGQDVAIKVIKPETWT--- MLKz_a-2_Smoe TNGWK-IPLDAPDDWEIDSSQLKRIKKILPSSNGDIYRGTFCGQDVAIKVIKPETWT--- MLKz_f_Smoe EPRGDEQAVEAAEEWMIDLSKLLLGPRFASGAHSRLYHGIYQGKAVAVKVTRHPQGCESA MLKz_d-2_Smoe DARSPTEGLEGYDDWTLDLRRLAMGHAFAQGASGRLYRGTYDGEDVAVKILERPKNNAE- MLKz_e-1_Smoe EGIGEVKAVERSEEWVVDMTQLFLGHKFASGAHSRLYHGIYKGKAVAVKVMRQPDEDEEV MLKz_g-2_Smoe DGGAP-CKLDVDERWIIDPRMLLVGSKLGEGAHGKVYEGKYRDLSVAVKIIQVGDTPED- MLKz_g-1_Smoe DGGAP-CKLDVDERWIIDPRMLLVGSKLGEGAHGKVYEGKYRDLSVAVKIIQVGDTPED- MLKz_d-1_Smoe DARSPTEGLEGYDDWTLDLRRLAMGHAFAQGASGRLYRGTYDGEDVAVKILERPKNNAE- MLKz_b-1_Smoe HGHVK-IPFDGKDDWEIDSEQLKLLHKVASGSFGDLFRGVYCGQDVAIKVLKPERLN--- MLKz_b-2_Smoe HGHVK-IPFDGKDDWEIDSEQLKLLHKVASGSFGDLFRGVYCGQDVAIKVLKPERLN--- :* : . .: . :..* : . **:*: MLKz_j_Smoe DG------ISDWRRVCLMRELRIWRKLDHPNIVKLIGASPGVADKNAFSNVCCLVSEYMS MLKz_e-2_Smoe ---------SRMVDRQFAHEVSLLSRLHHRNIVQFVAACKKP-------PVYCVVTEYLA MLKz_c_Smoe DSGTLRGAPAAELLQVFKQEVSIMRMVRHKNLVQFIGACANW-------PRLCIVTELMA MLKz_h_Smoe DG------ISDWRRVCLMRELRIWRKLDHPNIVKLIGASPGVADKNAFSNVCCLVSEYMS MLKz_a-1_Smoe ----------EHL-QEFVHEIAIMRKVRHKNIVQFIGACTTP-------PDLCIVTEYMS MLKz_a-2_Smoe ----------EHL-QEFVHEIAIMRKVRHKNIVQFIGACTTP-------PDLCIVTEYMS MLKz_f_Smoe TI------GTTTLDKLFAREVSLLSRLRHPNVVQLVGAWKRP-------PVCCVVTEYLA MLKz_d-2_Smoe --------RAQVMEQQFTQEVRMLAALKHQNVVRFIGACRKP-------LVWCIVTEYAK MLKz_e-1_Smoe ---------SRMVDRQFAHEVSLLSRLHHRNIVQFVAACKKP-------PVYCVVTEYLA MLKz_g-2_Smoe --------VAK-ARSRFVREVAMLSKVQHKNLVKFIGACEEP-------M--VLVTELLS MLKz_g-1_Smoe --------VAK-ARSRFVREVSMLSKVQHKNLVKFIGACEEP-------M--VLVTELLS MLKz_d-1_Smoe --------RAQVMEQQFTQEVRMLAALKHQNVVRFIGACRKP-------LVWCIVTEYAK MLKz_b-1_Smoe ----------EDLQKEFAQEVFIMRKVRHKNVVQFIGACTKP-------PNLSIVTEYMS MLKz_b-2_Smoe ----------EDLQKEFAQEVFIMRKVRHKNVVQFIGACTKP-------PNLSIVTEYMS : :*: : : * *:*:::.* :*:* MLKz_j_Smoe TGSLREYLMSQHK-RLSYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSA-LRAK MLKz_e-2_Smoe GGSLRGFLHKNEPSSLPLKVTLGMAMDIARGMEYIHSQRVIHGDLKSENLVLDSD-MCVK MLKz_c_Smoe GGSVRDVLESREG-GLEVPAALKVLRDAAKGMDFLHRRGIVHRDLKSANLLIDEH-DVVK MLKz_h_Smoe TGSLREYLMSQHK-RLSYKLVIQLGIDIARGLEYLHSRKIIHRDVKTKNILLDSA-LRAK MLKz_a-1_Smoe GGTVHDYLQKQKG-NLHLYVLLRIALDIAKGMDYLHQNNIIHRDLKASSLLMDEN-GVVK MLKz_a-2_Smoe GGTVHDYLQKQKG-NLHLYVLLRIALDIAKGMDYLHQNNIIHRDLKASSLLMDEN-GVVK MLKz_f_Smoe GGSLKDFLRSNGGAALPLRMVVDMALDIARGIRYLHSQGVVHRDLKSANLILDDE-FNVK MLKz_d-2_Smoe GGSVRSFLSKRKSRPVPLKLAVKQALDIAQGMQYLHNLGFIHRDLKSDNLLIATD-KSIK MLKz_e-1_Smoe GGSLRGFLHKNEPSSLPLKVTLGMAMDIARGMEYIHSQRVIHGDLKSENLVLDGD-MCVK MLKz_g-2_Smoe GNSLRKYLVNLRPHRMELEQAITFALEIAQVMDCLHANGIIHRDLKPDNLLLTADQKSVK MLKz_g-1_Smoe GNSLRKYLVNLRPHRMELEQAITFALEIAQVMDCLHANGIIHRDLKPDNLLLTADQKSVK MLKz_d-1_Smoe GGSVRSFLSKRKSRPVPLKLAVKQALDIAQGMQYLHNLGFIHRDLKSDNLLIATD-KSIK MLKz_b-1_Smoe GGSVYDYLHKHRS-VLKLPMALRVAIDVSKGMDYLHQNNIVHRDLKAANLLMDEN-EVVK MLKz_b-2_Smoe GGSVYDYLHKHRS-VLKLPMALRVAIDVSKGMDYLHQNNIVHRDLKAANLLMDEN-EVVK .:: * . : : : :: : :* .:* *:*. .::: * MLKz_j_Smoe IGDFDSARILMEA---------DQAMSGEIGTFGYMAPEVMD--------GR-AYDCKSD MLKz_e-2_Smoe ITDFGVARCEADA---------PSVGKADVGTYRWMAPEMIS--------GKNKCSTKVD MLKz_c_Smoe VCDFGVARLKPSNVNRSGSGNWPAEMTAETGTYRWMSPEVLE--------HK-AYDHKTD MLKz_h_Smoe IGDFDSARILMEA---------DQAMSGEIGTFGYMAPEVMD--------GR-AYDCKSD MLKz_a-1_Smoe VADFGVARIQDQ----------DGIMTAETGTYRWMAPEVLG--------HS-HYDQKAD MLKz_a-2_Smoe VADFGVARIQDQ----------DGIMTAETGTYRWMAPEVLG--------HS-HYDQKAD MLKz_f_Smoe ITDFGVAALESEC---------GDSVTSDVGTFRWMAPELVN--------GK-AHSRKVD MLKz_d-2_Smoe IADFGVARIEVQ----------TEGMTPETGTYRWMAPEMIQ--------HR-LYTHKVD MLKz_e-1_Smoe ITDFGVARCEADA---------PSVGKADVGTYRWMAPEMIS--------GKNKCSTKVD MLKz_g-2_Smoe LADFGLAREESV----------TEMMTAETGTYRWMAPELYSTVTLRNGEKK-HYNQKVD MLKz_g-1_Smoe LADFGLAREESV----------TEMMTAETGTYRWMAPELYSTVTLRNGEKK-HYNQKVD MLKz_d-1_Smoe IADFGVARIEVQ----------TEGMTPETGTYRWMAPEMIQ--------HR-LYTHKVD MLKz_b-1_Smoe VADFGVARVKDH----------TGVMTAETGTYRWMAPEVIE--------HK-PYDHKAD MLKz_b-2_Smoe VADFGVARVKDH----------TGVMTAETGTYRWMAPEVIE--------HK-PYDHKAD : **. * . : **: :*:**: * * MLKz_j_Smoe VFSFGICLLEIYSCDMAYGLVCLSLADITKGLVYRNLRPKIPRS--CPGELAYVMKRCWK MLKz_e-2_Smoe VYSFGIVLWELVTGQVPFQE--MQAVQVAYAVLHKDARPEVPEN--CPSALAALMRRCWS MLKz_c_Smoe VYSFGIMIWELLTGDIPYSD--LTPLQAAIGVVQRKLRPSMPAS--VPDKLVNLAERCWN MLKz_h_Smoe VFSFGICLLEIYSCDMAYGLVCLSLADITKGLVYRNLRPKIPRS--CPGELAYVMKRCWK MLKz_a-1_Smoe VFSFGVLLWELLTKKVPYEL--MTPFQVAVGVLQEELRPTIPQD--AHPKFSQLLEWCWR MLKz_a-2_Smoe VFSFGVLLWELLTKKVPYEL--MTPFQVAVGVLQEELRPTIPQD--AHPKFSQLLEWCWR MLKz_f_Smoe AYSFAIVLWELLTRQTPFQD--MTPVQAAFAVVNKNARPEVPRD--CPSVLSQLMQRCWS MLKz_d-2_Smoe VYSFGIVLWELITGLLPFQN--MTAVQAAFAVVNRGYRPGIPAD--CPPALAEIMSRCWD MLKz_e-1_Smoe VYSFGIVLWELVTGQVPFQE--MQAVQVAYAVLHKDARPEVPEN--CPSALAALMRRCWS MLKz_g-2_Smoe VYSFAIVLWELLTNRMPFEG--MSNLQAAYAAAFKNVRPSHPESEKLPEELVFILQSCWA MLKz_g-1_Smoe VYSFAIVLWELLTNRMPFEG--MSNLQAAYAAAFKNVRPSHPESEKVPEELVFILQSCWA MLKz_d-1_Smoe VYSFGIVLWELITGLLPFQN--MTAVQAAFAVVNRGYRPGIPAD--CPPALAEIMSRCWD MLKz_b-1_Smoe IFSFGVVLWELLTGKLPYDY--LTPLQAAVAVVQKGLRPVIPKN--THPKLAELMEKCWQ MLKz_b-2_Smoe IFSFGVVLWELLTGKLPYDY--LTPLQAAVAVVQKGLRPVIPKN--THPKLAELMEKCWQ :**.: : *: : .: : : : . . ** * . : : ** MLKz_j_Smoe KNPDKRPRMSEVVRMLEAIAKGRIF-------------------------------DSSL MLKz_e-2_Smoe ANPDKRPGFPEIVNTLEQLDDSSSK-------------------------------AMSY MLKz_c_Smoe QDPQLRPEFSEVRCFSSRCHVETAF-------------------------------V--- MLKz_h_Smoe KNPDKRPRMSEVVRMLEAIAKGRIF-------------------------------DSSL MLKz_a-1_Smoe TNPADRPDFSEITLVLKDIMSEVSR-------------------------------ALK- MLKz_a-2_Smoe TNPADRPDFSEITLVLKDIMSEVSR-------------------------------ALK- MLKz_f_Smoe LDPHARPDFEQLVETLEQFQLSMER-------------------------------NWSS MLKz_d-2_Smoe ANPDSRPGFAQVVKMLEEARAEIV------------------------------------ MLKz_e-1_Smoe ANPDKRPGFPEIVKTLEQLDDSSSK-------------------------------AMSY MLKz_g-2_Smoe EDPSVRPNFAQVVRMLTAFLFSLPGPQRAPPKQIIVSKNFGGKDLSPSPSPSPGGSNSTS MLKz_g-1_Smoe EDPSVRPNFAQVVRMLTAFLFSLPGPQRAPPKQIIVSKNFGGKDLSPSPSPSPGGSNSTS MLKz_d-1_Smoe ANPDSRPGFAQVVKMLEEARAEIV------------------------------------ MLKz_b-1_Smoe SNAAERPEFSIITLVLQDVYKEVIS-------------------------------SLSR MLKz_b-2_Smoe SNAAERPEFSIITLVLQDVYKEVIS-------------------------------FLSR :. ** : : MLKz_j_Smoe LR-FKF------LFLM-V---CLEASSFVVLFDKNA-I--FCQVIR MLKz_e-2_Smoe NT------------WH-WPS--ERTKSFLGCFSRCKKCTPVRCNCK MLKz_c_Smoe ---------------------------------------YSGVDHH MLKz_h_Smoe LR-FKF------LFLM-V---CLEASSFVVLFDKNA-I--LCQVIR MLKz_a-1_Smoe ----------------------------------------TVLTLD MLKz_a-2_Smoe ----------------------------------------TALTLD MLKz_f_Smoe R-------------------------------------SDDPLEKW MLKz_d-2_Smoe ------------HSVG-------K-AR-----FRCG-CMARPLTND MLKz_e-1_Smoe NT------------WH-WPS--ERTKSFLGCFSRCKKCTPVRCNCK MLKz_g-2_Smoe RMETPMSAAGSSSSVAGNGSLSTKHSRLFQCFGQCF-LSGAPGSLH MLKz_g-1_Smoe RMETPMSAAGSSSSVAGNGSLSTKHSRLFQCFGQCF-LSGAPGSLH MLKz_d-1_Smoe ------------HSVG-------K-AR-----FRCG-CMARPLTND MLKz_b-1_Smoe VVLTEY------SQIGEEESEKKK---------KSG-IFSAFRRNL MLKz_b-2_Smoe VVLTEY------SQIGEEESEKKK---------KSG-IFSAFRRNL