CLUSTAL W (1.83) multiple sequence alignment MOK_Hsap M----------------------------------------------------------- MOK_Mmus M----------------------------------------------------------- MOK_Spur ------------------------------------------------------------ AqueK133_Aque MPETLPL----------------------------------------------------- MOK_Smoe MRRTCDVRDRCRHVRHGSCDTGALSSSRAAFSKCTVSSLFFFLPCSLASLFSSHCCGKMD GK040_Glam MAEATTSA---------------------------------------------HESKSSS MOK_Hsap -KNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQRFESIEQVNNLREIQALRRLNPH MOK_Mmus -KNYKAIGKIGEGTFSEVMKMQSLRDGNYYACKQMKQHFESIEQVNSLREIQALRRLNPH MOK_Spur ---YRVLGKKGEGTFSEVLKCQNIQDGTYYACKKMKQNYQSLEQVNNLREIQAMKRLSPH AqueK133_Aque VGDYRVVGAMGEGTFSEVLKCQSLLDGKLYACKKMKQKYSNMTQVNNLREIQALRRLNPH MOK_Smoe SLEYRMICKKGEGTFSEVLKAQCHKSNKYVAIKCMKNTFDSLEQVTNLREIQALQRLSPH GK040_Glam SHKYKFVSKKGAGAFSDVIKAQCVKTEEYVAIKRMKATFKSIEQITSLREIQSLRRLADQ *: : * *:**:*:* * * * ** :..: *:..*****:::** : MOK_Hsap PNILMLHEVVFDRKSGSLALICELMDMNIYELIRGRRYPLSEKKIMHYMYQLCKSLDHIH MOK_Mmus PNILALHEVVFDRKSGSLALICELMDMNIYELIRGRRHPLSEKKIMLYMYQLCKSLDHMH MOK_Spur ANILELKEVIFDRKTGNLSLVCELMDMNIYELIRGRRHYLPQEKVKNYIYQLIKALEHMH AqueK133_Aque PNVIELKEVIFDRQTGTLSLICELMNMNIYELIKDRRSYLPEARVRLYTYQLCKSLYHMH MOK_Smoe TNVIKLLEVLYDQPTGRLALVFELMDMNIYELIRGRRTYVSEDRIKSYMFQLLKAMDHMH GK040_Glam PFIIRLIEILFDRTTGRLALVFELMEMNLYELIKNRKYHLPESSIKWYMWQLLHAVRIAH . :: * *:::*: :* *:*: ***:**:****:.*: :.: : * :** ::: * MOK_Hsap RNGIFHRDVKPENILIKQ-DVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFY MOK_Mmus RNGIFHRDVKPENILVKQ-DVLKLGDFGSCRSVYSKQPYTEYISTRWYRAPECLLTDGFY MOK_Spur RNGIFHRDVKPENILIRD-DHLKLADFGSCRSVYSKQPFTEYISTRWYRAPECLLTDGYY AqueK133_Aque RNGIFHRDVKPENILIKD-DLLKLADFGSCKSMYSKLPFTEYISTRWYRAPECLLTDGHY MOK_Smoe RNGIFHRDIKPENILIME-ESLKLADLGSCRGVYSKQPYTEYISTRWYRAPECLLTDGYY GK040_Glam ASGTFHRDIKPENILLDDKDNLKLSDFGSCRGIHTQLPYTEYISTRWYRSPECLLTDGVY .* ****:******: : : ***.*:***:.:::: *:**********:******** * MOK_Hsap TYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPAQKILTKFKQ---SRAMN MOK_Mmus TYKMDLWSAGCVFYEIASLQPLFPGVNELDQISKIHDVIGTPCQKTLTKFKQ---SRAMS MOK_Spur SYQMDMWSVGCVFYEILSLHPLFPGANEVDQIAKIHDVMGTPDATILNKFRN--KARGIN AqueK133_Aque GHKMDMWSVGCVLFELMSLRPLFPGSNELDQISKIHDVVGTPSSQVLDKFRK-IQSKSMD MOK_Smoe NYKMDMWGVGCVFFEIISLFPLFPGTNELDQIQKIHKVMGTPPQQLLDKMRR-------- GK040_Glam GPEMDLFGVGCVMFEITALFPLFPGKDELDQITRIHAILGTPPKELIQRIRKGAKNNPIK :**::..***::*: :* ***** :*:*** :** ::*** : :::. MOK_Hsap FDFPFKKGSGIPLLTTNLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQEQRKTEKRAL MOK_Mmus FDFPFKKGSGIPLLTANLSPQCLSLLHAMVAYDPDERIAAHQALQHPYFQVQRAAETQTL MOK_Spur YNFPSKKGSGIEKLLPNATKQTLEIMNKLCTYDPDERITAKQVIRHAFFKDLRDADKRKQ AqueK133_Aque FNFPYKHPTGISILLKHASKQCIDLITKLCTYDPEERPSAKETLRHPYFKELREAERRSK MOK_Smoe ------------------------------------------------------------ GK040_Glam GDFPPQKGSGLAKLIPHASSTAIDLMLKLMEYDPQKRITAEEALRHPFFKDIGEIVRLKA MOK_Hsap GSH-R------------------------KAGFPEHP--VAPEPLSNSCQISKEGRKQKQ MOK_Mmus AKH-R------------------------RAFCPKFS--MVPESSSHNWSFSQEGRKQKQ MOK_Spur HVEKK-----------------------KLSLGDQGS--VISEDTAKE--SHVEGKDGD- AqueK133_Aque LRL-K-----------------------SDVMQPELS--MKQQQHQHK--HYKQGRGKQ- MOK_Smoe ------------------------------------------------------------ GK040_Glam PTMPAGCLEKLGFTLDGRGADAEDGTGARKATRERHGDTVEGTPTPGDLAVTEETRSRQV MOK_Hsap SLKQEEDR--PKRRG-----------P-----------AYVMELP---KLKLSGV----- MOK_Mmus SLRHEEGH--ARRQG-----------P-----------TSLMELP---KLRLSGM----- MOK_Spur NDNHKAVRK-ARRKSKL--------------HESEN--YSSTLLP---KVQNNKMVGHSI AqueK133_Aque RERDEFVPV-KQRQYYIPVLASQAQGPPPGVHGSMMSSLTLPQLPKPPQLQVKGEQQV-- MOK_Smoe ------------------------------------------------------------ GK040_Glam AKRPQKTPPGAKRIGPSGVL----QAGQGGTNGLLVSMGSLTQTNHPPKLSDSKSTD--N MOK_Hsap --------VRLSSYSSPTLQSVLGSG----------------TNGRVPVLRPLKC----- MOK_Mmus --------TKLSSCSSPALRSVLGTG----------------ANGKVPVLRPLKC----- MOK_Spur SN---YPTQTFGSTSFPKLHTNNN-------------------RHQQSMLPSIAN----- AqueK133_Aque -L---HGVNSGLSTGLPSLAQSMKAGPSHI------------ARHQQPHISPFPS----- MOK_Smoe ------------------------------------------------------------ GK040_Glam VLPHKHFQASEQEGSVPKLPTL-TRTPPARTNHGLTNVVLQGSNSAQTKLGPQTKQQLIF MOK_Hsap IP--ASKK-TDPQKDLKPAPQ-----QCRLPTIVR-----------------------K- MOK_Mmus AA--VNKK-TDTQKDIKPHLK-----HYHLPTINR-----------------------KG MOK_Spur TH--YNKH-HHTTKTFQPAASKNVYGHFQLPSISKS----------------------KE AqueK133_Aque LL--ASTNPSAKSNTMFPTGRHHQIGPTHLPSLGKP-------------------YYVQR MOK_Smoe ------------------------------------------------------------ GK040_Glam TKQTHGGK-GKTSTSVSPGLE-----QNNLPVLGAKNYTVTTQRPYQNKIGVSSPYRDHV MOK_Hsap GGR MOK_Mmus GEY MOK_Spur AQF AqueK133_Aque TNQ MOK_Smoe --Y GK040_Glam KRK