CLUSTAL W (1.83) multiple sequence alignment MPSK1_Hsap MGHA----------LCVC---SRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGL------- MPSK1_Mmus MGHA----------LCVC---SRGTVIIDNKRYLFVQKLGEGGFSYVDLVEGL------- DDB0216373_Ddis MGSS----------LSLC-YPSDKTFNINGVKYTVNRILGEGGFSFVYLVKDN------- CG1227_Dmel MQSIGWTLIMKRGCLFSC---RKETLNINGSRYTIRERLATGGFSLIDLGENA------- YPL236C_Scer MISIVLELFQ---NLCCCRGFSDATIRVNDKRYRIQRLLGEGGMSFVYLVQLSKNSL--I MPSK1_Spur MGC-------------TC---TKDRVTVGGRRFYVMKRLGEGGFSVVDQVEDE------- AqueK173_Aque MGAL----------WSLL---FGRTLSINGESYRVVRRIGEGGFSYVDLVRGR------- AqueK174_Aque ------------------------------------------------------------ NAK_b-1_Smoe MGCSFSGLN----ALYEA-VSGAADIWINQRRFRIVRQLGEGGFAFVYLAREIQGDRPLK NAK_b-2_Smoe MGCSFSGLN----ALYEA-VSGAADIWINERRFRIVRQLGEGGFAFVYLAREIQGDRPLK MPSK1_Hsap -----HDGHFYALKRILCHEQQDREEAQREADMHRLFNHPNILRLVAYCL-RERG----- MPSK1_Mmus -----HDGHFYALKRILCHEQQDQEEAQREAEMHRLFQHPNILRLMAYSL-KERG----- DDB0216373_Ddis -----SNSKKYALKVMICQTQESINTAKREINAFQTFNHENIMKLIDHSI-SNHSQ---- CG1227_Dmel -----STRRSYAIKRITCHSIDDQNIALREIENCRKIDSENVIRVVDYEL-KGQAD-IVI YPL236C_Scer IDNGIATPELYALKKIICPSVESISNGMREIENYKRFQSPYVIKSIDSQVMQEKD----- MPSK1_Spur ------VGEKFALKRIQCHGAEDDRQAKKEAEYHCQFKHKNLIGLEEWGSVKGKE----- AqueK173_Aque ------NGEQFALKQLLIQVEEQRESVEREIYMHQTVTHPNVLQLVDSQI-TEQGN---- AqueK174_Aque ------------------------------------------------------------ NAK_b-1_Smoe QSSQVSDDGLYAVKKVLIQSEEQLALVKREIQVSSLFKHPNLLPLLEHSMIAVK-GSREG NAK_b-2_Smoe QSSQVSDDGLYAVKKVLIQSEEQLALVKREIQVSSLFKHPNLLPLLEHSMIAVKQGSREG MPSK1_Hsap -AKHEAWLLLPFFKRGTLWNEIERLK------DKGNFLTEDQILWLLLGICRGLEAIHAK MPSK1_Mmus -AKHEAWLLLPFFKKGTLWNEIERLK------DQGSFLTEDQILPLLLGISRGLEAIHAK DDB0216373_Ddis -DTKEYRLLLPYYKDGTLQDLIDNQRTIYGKDTKKPLFKEKKCLQFFLKVCEAIQVFHNH CG1227_Dmel NTTSTLFIVLPYYKHGSLADHLQLRS------RKQDHMPEAQILQIFLGVCEGLKAIHEA YPL236C_Scer -GSKTIYIVLPYYSLGSLQDSINRRL------LEGTFVSEAECVRIMLGVTRGLLCLHDP MPSK1_Spur -GVTEILLVLPLFKRGTLQDELDKMK------ADGRCMAEERIWRIFKGVCEGIKALHTA AqueK173_Aque -GEARGLLLFPFYQYGTLEDEIEAIM------SRGRKISEERILNLFLSACQGLHALHTS AqueK174_Aque ------------------------------------------------------------ NAK_b-1_Smoe TWNTEAYLLFPVYPDGTLQSQLEEMR------SRGEFFPAVTVLHIFQQICQALKQMHKH NAK_b-2_Smoe TWNTEAYLLFPVYPDGTLQSQLEEMR------SRGEFFPAVTVLHIFQQICQALKQMHKH MPSK1_Hsap ----------------------------------------------GYAHRDLKPTNILL MPSK1_Mmus ----------------------------------------------GYAHRDLKPTNILL DDB0216373_Ddis S--------------------------------------------PPLAHRDIKPGNIVL CG1227_Dmel M-------------------------------------------PVPLAHRDLKTANICL YPL236C_Scer ASRQDNATSRVNVDAVSMTYSDETAMLLEDTPLEMDMLSSNSAGSIAYAHRDITPSNILF MPSK1_Spur K-------------------------------------------PKPLAHRDMKPGNVML AqueK173_Aque G-------------------------------------------NEGLAHRDIKPGNLLL AqueK174_Aque ------------------------------------------------------------ NAK_b-1_Smoe --------------------------------------------DPSYSHNDVKPGNVLL NAK_b-2_Smoe --------------------------------------------DPSYSHNDVKPGNVLL MPSK1_Hsap GD--------------------------------------------------------E- MPSK1_Mmus GD--------------------------------------------------------E- DDB0216373_Ddis QNLRRPSNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNSEDSDI CG1227_Dmel SD--------------------------------------------------------S- YPL236C_Scer SSD--------------------------------------------------------- MPSK1_Spur AE--------------------------------------------------------D- AqueK173_Aque SD--------------------------------------------------------N- AqueK174_Aque ------------------------------------------------------------ NAK_b-1_Smoe SKSS-----------------------------------------------------NQD NAK_b-2_Smoe SKSS-----------------------------------------------------NQD MPSK1_Hsap -GQPVLMDLGSMNQACIHVEGSRQALTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDV MPSK1_Mmus -GQPVLMDLGSMNQACIQVEGSRQALALQDWAAQRCTISYRAPELFSVQSHCVIDERTDV DDB0216373_Ddis EAIPILMDFGSVREARIKIENRKDALSLQDEVEQNTTPFYRAPELFDIPSDCQIDERIDV CG1227_Dmel -FEPIIVDLGSMTEARLQIVGQTDAQRLQDEAEERSSIVYRAPELFTVKTYCTIDERTDI YPL236C_Scer -GLPVIGDLGSCSQADITIENRHQLSELQEWVNDNCTLPYTPPELLNLKLNQVLSSKVDI MPSK1_Spur -DTPVIMDFGSMGEARIEVKGRSEACALQDLAAEKCSMLFRAPELFHVDSHCIVEEKVDI AqueK173_Aque KEELVIMDLGSAASGQVTVNDRKEAIALQEHCAQTCTAMYRAPELFEVPSQSVITLKSDI AqueK174_Aque ------MDLGSAASGQVTVNDRKEAIALQEHCAQTCTAMYRAPELFEVPSQSVITLKSDI NAK_b-1_Smoe PPKAVVMDFGSATLARKRVRSRSEALAIQEWAAEHCSAPYRAPELWDCPSIADIDERVDV NAK_b-2_Smoe PPKAVVMDFGSATLARKRVRSRSEALAIQEWAAEHCSAPYRAPELWDCPSIADIDERVDV *:** . : . : :*: : : : .*** : : *: MPSK1_Hsap WSLGCVLYAMMFGEGPYDMVF-QKGDSVALAVQ-NQLS--IPQSPRHSSALRQLLNSMMT MPSK1_Mmus WSLGCVLYAMMFGEGPYDMVF-QKGDSVALAVQ-NELS--IPQSPRHSSALRQLLSSMMT DDB0216373_Ddis WALGCLLYTMAYNNSPFEVCDNEPNGSVALKVLSGLPKPFPPSQTNYSNQFNQLIIDMVN CG1227_Dmel WSLGCVLYAMCYFNSPYDPIY-ERGDSVALAVLSGNIN--IPEDSIYTEDMHELIKYMLR YPL236C_Scer WSLGCTFYTLMFGISPFEREEQIHGASLTYAINTGKYS--FPRNSRFSEGLLSVIKKCIQ MPSK1_Spur WSLGCVLFNMAYLHSPFEPIY-ARGDSIHLAVLGRNFK--FPENSRYSQGLQDTVSGMLV AqueK173_Aque WSLGCSIYAAAFGTSPCDG--------SALSAMSGRIM--FPKNHSYSLEFCNLITWILK AqueK174_Aque WSLGCSIYAAAFGTSPCDG--------SALSAMSGRIM--FPKNHSYSLEFCNLITWILK NAK_b-1_Smoe WSLGCTLFAIMYCVSPFEHSLGEAGGSLQLASMSGQIK--WPSTPPYPRSFHKLVSWMVE NAK_b-2_Smoe WSLGCTLFAIMYCVSPFEHSLSEAGGSLQLASMSGQIK--WPSTPPYPRSFHKLVSWMVE *:*** :: : .* : * .. : . : : MPSK1_Hsap VDPHQRPHIPLLLSQLEALQPPAPGQ-HTTQI MPSK1_Mmus VDPQQRPHIPVLLSQLEALQPPAPGQ-HTTQI DDB0216373_Ddis LDKDERLHLNQVIERINQII----------QS CG1227_Dmel TDPMERPFVFSVIERTHDLIQKL-----EGRL YPL236C_Scer VDPIQRPTTSQLLNLLQDL-----------DT MPSK1_Spur VEAVERPNIDWVLNKTTEGQLN-----MENRI AqueK173_Aque VNPEERPTVQEVEQLIGTILSKQVT--PHGNV AqueK174_Aque VNPEERPTVQEVEQLIGTILSKQVT--PHGNV NAK_b-1_Smoe PRVANRPDVEAVIAVVTKMLSKFPEEVDSSVF NAK_b-2_Smoe PRVANRPDVEAVIAVVTKMLSKFPEEVDSSEF :* :