CLUSTAL W (1.83) multiple sequence alignment MSK2_Hsap MGD--------------------------------------------------------- MSK1_Hsap MEE--------------------------------------------------------- MSK2_Mmus MGD--------------------------------------------------------- MSK1_Mmus MEG--------------------------------------------------------- C54G4.1_Cele ME---------------------------------------------------------- JIL1_Dmel MSRLQKQNYEILSGTSTSRLKNHQHPRESESLAYEEPDQMVRNHLNGQLVANGNGKTRKN MSK_Spur ------------------------------------------------------------ AqueK023_Aque ------------------------------------------------------------ MSK2_Hsap ----------------EDDDE--------------------------------------- MSK1_Hsap ----------------EGGSSGGA-AGT-------------------------------- MSK2_Mmus ----------------EDEDE--------------------------------------- MSK1_Mmus ----------------EGGGSGGA--GT-------------------------------- C54G4.1_Cele ------------------------------------------------------------ JIL1_Dmel SNSETMTNGKKSKLNTEGSGSGSGKTLNYNNNNNNNNSISATNGQYTNSSSKTTSASARD MSK_Spur ------------------------------------------------------------ AqueK023_Aque ------------------------------------------------------------ MSK2_Hsap --------------------------------------------------SCAVELRITE MSK1_Hsap ------------------------------SA----------DGGDGGEQLLTVKHELRT MSK2_Mmus --------------------------------------------------GCAVELQITE MSK1_Mmus ------------------------------SG----------DSGDGGEQLLTVKHELRT C54G4.1_Cele --------------------------------------------D--------------- JIL1_Dmel YTYRETISPPTPPSPPTTNVADIVCISDAESEDGRDPEREYYDQDMEEDEPNGIEIDESS MSK_Spur ------------------------------------------------------------ AqueK023_Aque ------------------------------------------------------------ MSK2_Hsap ANL--------------------------------------------------------- MSK1_Hsap ANL--------------------------------------------------------- MSK2_Mmus ANL--------------------------------------------------------- MSK1_Mmus ANL--------------------------------------------------------- C54G4.1_Cele -IL--------------------------------------------------------- JIL1_Dmel SSLSKAKSNNAAAAAAAAAAAAAAAASKASSSTTPSYAMPTSNSTPLDLDNEAHQRDLEA MSK_Spur ------------------------------------------------------------ AqueK023_Aque ------------------------------------------------------------ MSK2_Hsap ---------TGHEEKVSVENFELLKVLGTGAYGKVFLVRKAGGHDAGKLYAMKVLRKAAL MSK1_Hsap ---------TGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDTGKLYAMKVLKKATI MSK2_Mmus ---------TGHEEKVSVENFALLKVLGTGAYGKVFLVRKTGGHDAGKLYAMKVLRKAAL MSK1_Mmus ---------TGHAEKVGIENFELLKVLGTGAYGKVFLVRKISGHDAGKLYAMKVLKKATI C54G4.1_Cele ---------MPEGEKVSMENFALLRVLGKGAYGKVFLVRKVGGKDHNTIYAMKVLRKTRV JIL1_Dmel VTDLKYYVKLYSDEAVSLNDFKIIRVLGTGAYGRVFLVRKLTRHDAGKLYAMKVLNKITV MSK_Spur ------------------------------AYGKVFLVRKVGNHNQGKLYAMKVLKKATI AqueK023_Aque -----------HRVAIGPEDFELLTVLGTGGYGKVFLVRKVTGADQKQLYAMKVLKKTSV .**:****** : :******.* : MSK2_Hsap VQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY MSK1_Hsap VQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER MSK2_Mmus VQRAKTQEHTRTERSVLELVRQAPFLVTLHYAFQTDAKLHLILDYVSGGEMFTHLYQRQY MSK1_Mmus VQKAKTTEHTRTERQVLEHIRQSPFLVTLHYAFQTETKLHLILDYINGGELFTHLSQRER C54G4.1_Cele LTKQKTLEHTMAERQVLERLRGTPFLVNLFYAFQTDTKLHIVMEYVRGGELFTHLCSRGH JIL1_Dmel VQKRKTAEHTKTERVVLEAIQRNPFLVSLHYAFQSSSKLYLVLDFANGGELFTHLYHSEN MSK_Spur VQKAKTAEHTMTERQVLEAVRSCPFLVTLHYAFQTDSKLNLILDYVNGGELFTHLYQREH AqueK023_Aque VRKKKVMEHTLTERSVLEAIRDFPFLVTLHYAFQTETKLHLVMDYLCGGELFTHLHQIGP : : *. *** :** *** :: ****.*.****:.:** ::::: ***:**** MSK2_Hsap FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE MSK1_Hsap FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETE MSK2_Mmus FKEAEVRVYGGEIVLALEHLHKLGIIYRDLKLENVLLDSEGHIVLTDFGLSKEFLTEEKE MSK1_Mmus FTEHEVQIYVGEIVLALEHLHKLGIIYRDIKLENILLDSNGHVVLTDFGLSKEFVADETE C54G4.1_Cele FDLEAARFVIAELVVAIDSLHQRKVIYRDLKLENILLDEEGHVKLTDFGLSKLFLPGELD JIL1_Dmel FEESRVRVYIAEVVLALEQLHQLGIIYRDIKLENILLDGEGHIVLSDFGLSKILTAENEY MSK_Spur FRESEVRIYIAEIIIALDCLH--------------------------------------- AqueK023_Aque FSESGSRLYGAEITLALEHLHSLNILYRDIKLENILLDRDGHIVLTDFGLSKTMKPDQ-- * :. .*: :*:: ** MSK2_Hsap RTFSFCGTIEYMAPEIIRS-KTGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVS MSK1_Hsap RAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEIS MSK2_Mmus RTFSFCGTIEYMAPEIIRS-KAGHGKAVDWWSLGILLFELLTGASPFTLEGERNTQAEVS MSK1_Mmus RAYSFCGTIEYMAPDIVRGGDSGHDKAVDWWSLGVLMYELLTGASPFTVDGEKNSQAEIS C54G4.1_Cele RANSYCGTIEYMSPEVINRPEGGYSDVVDWWSLGVISFELLTGCSPFTVDGAQNSSKDIA JIL1_Dmel RAHSFCGTLEYMAPEIIRTGPPGHDSAVDWWSVGVLTFELLTGASPFATSDGQVQQSEIS MSK_Spur ------------------------------------------------------------ AqueK023_Aque VAHSYCGTVEYMAPEIIRGGDDGHNLLVDWWSLGVLLHELLTCESPFAPTGEDNSQKEIS MSK2_Hsap RRILKCSPPFPPRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVRNHPFFQGLDWVALAA MSK1_Hsap RRILKSEPPYPQEMSALAKDLIQRLLMKDPKKRLGCGPRDADEIKEHLFFQKINWDDLAA MSK2_Mmus RRILKCSPPFPLRIGPVAQDLLQRLLCKDPKKRLGAGPQGAQEVKSHPFFQGLDWVALAA MSK1_Mmus RRILKSEPPYPQEMSTVAKDLLQRLLMKDPKKRLGCGPRDAEEIKEHLFFEKIKWDDLAA C54G4.1_Cele KRIMTKKVPFPKTMDVDARDFIGQLLEKKLEKRLGYN--GVDEIKNHKFMSSIDWDAAVK JIL1_Dmel RRIQKEQPMIPSSFSANARDFVLKMLEKNPKRRLGGNHRDASEIKEHPFFNGINWQELRT MSK_Spur -RILTSHPPMPNTFSKEVKDFINKLLVKDPTKRLGCN--GVKDIKSHSFFKGLNWDDVAA AqueK023_Aque RRILYEAPPIPHKLSPSCRELLFGLMRKNKDERLGAN--GAHEVKSHRWFSSLNWDDVLA ** * :. :::: :: *. .*** . .. :::.* ::. :.* MSK2_Hsap RKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPPGSPPPGDPRIFQ-GYSFVAPSILFDH MSK1_Hsap KKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQ-SSEKLFQ-GYSFVAPSILFKR MSK2_Mmus RKIPAPFRPQIRSELDVGNFAEEFTRLEPVYSPAGSPPPGDPRIFQ-GYSFVAPSILFDH MSK1_Mmus KKVPAPFKPVIRDELDVSNFAEEFTEMDPTYSPAALPQ-SSERLFQ-GYSFVAPSILFKR C54G4.1_Cele RTLKPVIVPRIGHDLDTQFFSAEFTSQPPLYSPAESPL-NANTLFR-GYSYVSPSVIFAN JIL1_Dmel KRRKAPYKPTLTAEDDVQNFSNEFTDQVPEDPECDAPP-SRIRLFR-GYTYVAPEHLEQM MSK_Spur KRVSPPFRPHINGELDTSNFAEEFTSLVPADSPADIPKTADARVFRVGYSFIAPSILYSD AqueK023_Aque KKVRPPFKPYVSNEMDVGNFADEFTNQDPVDSPALPIS-KHNQVFR-GYSFIGPPVLFTS : . * : : *. *: *** * . :*: **:::.* : MSK2_Hsap NNAVMTDGLEAPGAGDRPGRAAVARSAMMQDSPFFQQYELDLREPA-LGQGSFSVCRRCR MSK1_Hsap NAAV-IDPLQFHMGVERPGVTNVARSAMMKDSPFYQHYDLDLKDKP-LGEGSFSICRKCV MSK2_Mmus NNAVMADVLQAPGAGYRPGRAAVARSAMMQDSPFFQQYELDLREPA-LGQGSFSVCRRCR MSK1_Mmus NAAV-IDPLQFHMGVDRPGVTNVARSAMMKDSPFYQHYDLDLKDKP-LGEGSFSICRKCV C54G4.1_Cele DNVI-GEELMAE-----------DVNALLASSSFFAKYKLDKSDAGLLGKGAFSVVRRCE JIL1_Dmel RRDN-HCEIQYF-------------NTGLQNIPC-RPDDLELGT-R-TSNGAYGTCHFVV MSK_Spur NAI-TQDMLTQPSEHNRPSLASILSIHELKDSPFNKYYELDMKSAP-IGDGSFSICRRCT AqueK023_Aque NTVL-SS----------------LPPLLLHDSPFLQKYELS--NTN-LGTGSFSTCRVCI : . . .*. . *::. : MSK2_Hsap QRQSGQEFAVKILSRRLEANTQREVAALRLC----QSHPNVVNLHEVHHDQ--------- MSK1_Hsap HKKSNQAFAVKIISKRMEANTQKEITALKLC----EGHPNIVKLHEVFHDQ--------- MSK2_Mmus QRQSGQEFAVKILSRRLEENTQREVAALRLC----QSHPNVVNLHEVLHDQ--------- MSK1_Mmus HKKTNQAFAVKIISKRMEANTQKEITALKLC----EGHPNIVKLHEVFHDQVAASAQPPG C54G4.1_Cele RVVDGAQFAVKIVSQKFASQAQREARILEMV----QGHPNIVQLHDVHSDP--------- JIL1_Dmel DSSTDLVFLAKIIPLSK--FRPSEVDALISCALDTTNHKNIVSYHGTFREK--------- MSK_Spur HRKTEKEYAVKIVSRRVA--CTQEITTLQLC----QKHPNIVHLKEEFKDK--------- AqueK023_Aque EKETKQEFAVKIVSKRH--NPMREISILQLC----QGHPNIVRLHEVLQDQ--------- : .**:. * * * *:* : : MSK2_Hsap --------------------------------------------------------LHTY MSK1_Hsap --------------------------------------------------------LHTF MSK2_Mmus --------------------------------------------------------LHTY MSK1_Mmus QVVLCSLLLLALLFNRSLTRKPVTWTWLVHSTSQLPPLPPPMPEIVLFILLSDNGQLHTF C54G4.1_Cele --------------------------------------------------------LHFY JIL1_Dmel --------------------------------------------------------CETW MSK_Spur --------------------------------------------------------LHTY AqueK023_Aque --------------------------------------------------------LHVY . : MSK2_Hsap LVLELLRGGELLEHIRKKRHFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD MSK1_Hsap LVMELLNGGELFERIKKKKHFSETEASYIMRKLVSAVSHMHD-VGVVHRDLKPENLLFTD MSK2_Mmus LVLELLRGGELLEHIRKKRLFSESEASQILRSLVSAVSFMHEEAGVVHRDLKPENILYAD MSK1_Mmus LVMELLNGGELFERIKRKKHFSETEASYIMRKLVSAVSHMHD-VGVVHRDLKPENLLFTD C54G4.1_Cele LVMEILTGNELLERIRKLERFTESEAADIMRQLVSAVKYLHD-KRIVHRDLKPENILFES JIL1_Dmel IVMEYLSGPELTASIRM----DEDSCREIFLQLVMAVRHIHS-KHFIHGDLKPENIMFEN MSK_Spur IIMELCKGGELLGRIRKKKHFDELEASMIMRKLVSAVDYMHS-RGIVHRDLKPENILFTD AqueK023_Aque IIMERLRGGELLDRIRSNNSFTEAQASHLFRQLVSAVHFIHS-KRVVHRDLKPENLIFSN :::* * ** *: * .. :: .** ** .:*. .:* ******::: . MSK2_Hsap DTP-GAPVKIIDFGFARLRPQSPGVP---------------------MQTPCFTLQYAAP MSK1_Hsap END-NLEIKIIDFGFARLKPPD-NQP---------------------LKTPCFTLHYAAP MSK2_Mmus DTP-GAPVKIIDFGFARLRPQSPAEP---------------------MQTPCFTLQYAAP MSK1_Mmus END-NLEIKVIDFGFARLKPPD-NQP---------------------LKTPCFTLHYAAP C54G4.1_Cele IDS-SARLRLVDFGFARLLPNSMEQQLKSVQVLRKMYGLIAHNHSLHSETPCFTLQYAAP JIL1_Dmel RE-D-RTVKLIDFGSACYNNRFK-SW---------------------KDKPRYTLDYAPP MSK_Spur DSD-DAELKIIDFGFARITN-SN-QP---------------------LKTPCFSLHFAAP AqueK023_Aque EDDDTAVLKIIDFGFARLLPEAP-QV---------------------LTTPCYTLPYGAP ::::*** * .* ::* :..* MSK2_Hsap ELLAQ-----QGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQA--AEIMCKIREG MSK1_Hsap ELLNQ-----NGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSA--VEIMKKIKKG MSK2_Mmus ELLAQ-----QGYDESCDLWSLGVILYMMLSGQVPFQGASGQGGQSQA--AEIMCKIREG MSK1_Mmus ELLTH-----NGYDESCDLWSLGVILYTMLSGQVPFQSHDRSLTCTSA--VEIMKKIKKG C54G4.1_Cele EVLDVG-DSQPEYNEQCDLWSLGVVLFTMLSGQVPFHARSRQ---ESA--TEIMQRICRA JIL1_Dmel EMLADA-N-LVTYSPAVDIYGLGATLYTMLVGHRPYRQNEDDVDHSAAAHHELRKRMRRG MSK_Spur EVLKRAYEQDGEYDASCDVWSLGVILYTMLSGRVPFQDPSISKS-NSA--SDIMKRIKHG AqueK023_Aque EVISH----SNGYTESCDIWSLGVILYTLLSGQAPFHAPTW-----PT--EKIVDCIQHG *:: * *::.**. *: :* *: *:: : .: : .. MSK2_Hsap RFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRGSSWLQDGSARSSPPLRTPDVL MSK1_Hsap DFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDIL MSK2_Mmus RFSLDGEAWQGVSEEAKELVRGLLTVDPAKRLKLEGLRSSSWLQDGSARSSPPLRTPDVL MSK1_Mmus DFSFEGEAWKNVSQEAKDLIQGLLTVDPNKRLKMSGLRYNEWLQDGSQLSSNPLMTPDIL C54G4.1_Cele EFSFTGDAWTNVSADAKNLITGLLTVDPKKRLSMQELTAHMWLKSSAS-MDTPLQTPSIL JIL1_Dmel TFNQRSMRWESASPAFRHLVSWCLQRDPADRPTLSDILDSEWLQYGSNDPDVDIILPQQM MSK_Spur NFSFDGEEWNSVSTPAKDLIKGLLTVDPSRRLTTDDLLQNEWIQGQQLSTSTPLMTPDIL AqueK023_Aque SVSFDSDEWSSVSSTAKSLIKGLLTVNTSQRLTIDSLSVHPWLMPDSA-PDTPLCTTVSL .. . * ..* : *: * :. * . . : *: . : . : MSK2_Hsap ESS-----------GPAVRSGLNATFMAFNR-GKREGFFLKS------------------ MSK1_Hsap GSS-----------GAAVHTCVKATFHAFNK-YKREGFCLQN------------------ MSK2_Mmus ESS-----------GPAVRSGLNATFMAFNR-GKREGFFLKS------------------ MSK1_Mmus GSS-----------GAAVHTCVKATFHAFNK-YKREGFCLQN------------------ C54G4.1_Cele PSS-----------A-D--ETFNETLRAFLH-ANRDGFHLLD------------------ JIL1_Dmel VVDLSEDTMEQPTGG-MFDDQQQLEFMHDK-SAEDEGITLVSEPMDTTVATHESRRNAAA MSK_Spur NSC-----------A-SIQKRVKATMRAFHT-AQREGFLLTD------------------ AqueK023_Aque KSL-----------G-ATRTAINHTLHAYYQVTSKDGLVLGD------------------ . : : . :*: * . MSK2_Hsap --------------------------------VENAPL--AK------------------ MSK1_Hsap --------------------------------VDKAPL--AK------------------ MSK2_Mmus --------------------------------VENAPL--AK------------------ MSK1_Mmus --------------------------------VDKAPL--AK------------------ C54G4.1_Cele --------------------------------VAAAPL--MK------------------ JIL1_Dmel FSSVVAPTTDDEIVHERFDPAFEVQADFYGFDENAPPLPLPEEYYSELPLPEEDRQYIPP MSK_Spur --------------------------------VSNAPL--AK------------------ AqueK023_Aque --------------------------------PAQNPL--AR------------------ ** . MSK2_Hsap -------------RR---KQKLRSATASRRGSP----APANPG----------------- MSK1_Hsap -------------RR---KMKKTSTSTETRSSS----SESSHS----------------- MSK2_Mmus -------------RR---KQKLRSAAASRRGSP----VPASSG----------------- MSK1_Mmus -------------RR---KMKRTSTSTETRSSS----SESSRS----------------- C54G4.1_Cele -------------RR---GIKRQSGDKDASGNS----KNSRVT----------------- JIL1_Dmel PPALIPVEPETTFRRPRTRQQRRTESQLVQPVSVATYEDSKASLRVLMQQLPPPGDNVVA MSK_Spur -------------RR---KKKKDSST-ETRSSS----SESTHS----------------- AqueK023_Aque -------------KR---KLKSERSPQ--------------------------------- :* : MSK2_Hsap ------------------------------------------------------------ MSK1_Hsap ------------------------------------------------------------ MSK2_Mmus ------------------------------------------------------------ MSK1_Mmus ------------------------------------------------------------ C54G4.1_Cele ------------------------------------------------------------ JIL1_Dmel RIPKRTHRVVRTLPPTFGTTKREENFYGFSKTAISWRKTRASWRHFCLLINGVQQVLKVR MSK_Spur ------------------------------------------------------------ AqueK023_Aque ------------------------------------------------------------ MSK2_Hsap ----------------------------RAPV-ASKGAPRRANGPL-------------- MSK1_Hsap ----------------------------SSSHSHGKTTPTKTLQPS-------------- MSK2_Mmus ----------------------------RLPASAAKGTTRRANGPL-------------- MSK1_Mmus ----------------------------SSSQSHGKTTPTKTLQPS-------------- C54G4.1_Cele -----QFECLPEEQEAEMTSSTSRPSNLGMMN------------YR-------------- JIL1_Dmel FKKARRVYCLPHIKEEKLDHAYEKPLTFPRPKAQLKRTKREPKVPR-------------- MSK_Spur ----------------------------QSSSSQESTTPTPTANPVLTIPVTTVSCAPRT AqueK023_Aque --------------------PGTRPTT--------------------------------- MSK2_Hsap ------------------------------------------------------------ MSK1_Hsap --------NPA------------------------------------------------- MSK2_Mmus ------------------------------------------------------------ MSK1_Mmus --------NPT------------------------------------------------- C54G4.1_Cele --------EPN------------------------------------------------- JIL1_Dmel --------PPT------------------------------------------------- MSK_Spur TTATGAPSIPSVQPLPSLSKQTGARLDQYESLESLGFSPILPFSAGGSQELPPLLARQDS AqueK023_Aque ------------------------------------------------------------ MSK2_Hsap ------------------------------------------------------------ MSK1_Hsap ------------------------------------------------------------ MSK2_Mmus ------------------------------------------------------------ MSK1_Mmus ------------------------------------------------------------ C54G4.1_Cele ------------------------------------------------------------ JIL1_Dmel ------------------------------------------------------------ MSK_Spur GYVGQMPSYAQVTPVPRTNVGSHGVTYAPILDPSMYPCGLQQPILDFSSSIPEYLSVQYA AqueK023_Aque ------------------------------------------------------------ MSK2_Hsap ----------------------------------------PPS MSK1_Hsap -------DSNNPETL------------------F--QFSDSVA MSK2_Mmus ----------------------------------------SPS MSK1_Mmus -------EGSNPDTL------------------F--Q---FSD C54G4.1_Cele -------SGTI----------------------R-ETRGSDSS JIL1_Dmel -------RVQP-ERA------------------RAMRQLYQFQ MSK_Spur STEQPSIPMTVPRTLHQPHPHPLPLPHQHLSHLPTISEDPSTT AqueK023_Aque --------LEI------------------------TDLKSATN