CLUSTAL W (1.83) multiple sequence alignment NDR1_Hsap MAMTG------------------------------------------------------- NDR2_Hsap MAMTAG------------------------------------------------------ sax-1_Cele ME---------------------------------------------------------- trc_Dmel MMSSRTQD---------------------------------------------------- CBK1_Scer MYNSSTNHHE-GAPTSGHGYYMSQQQDQQHQQQQQYAN---------EMNPYQQIPRPPA NDR_Spur MAQTQE------------------------------------------------------ CC1G_01990_Ccin MSSRPLPNPPFQYPQNYWGPVYGDSRNN-HHYQDQYHNPYGYPNYAHQPPDFDE------ CC1G_00855_Ccin MNSQGDRT---------------------------------------------------- CC1G_00325_Ccin MQGLNTQNIR-KTS---------------------------------------------- NDR2_Mmus MAMTAG------------------------------------------------------ NDR1_Mmus MAMTG------------------------------------------------------- * NDR1_Hsap ------------------------------------------------------------ NDR2_Hsap ------------------------------------------------------------ sax-1_Cele ------------------------------------------------------------ trc_Dmel ------------------------------------------------------------ CBK1_Scer AGFSSNYMKEQGS---------------------H------------------------- NDR_Spur ------------------------------------------------------------ CC1G_01990_Ccin -------QPATSSIPVGTLLHKGFYDLLAMIPTPSPSRLIWGSPPSPNKSSDLQAGPRYE CC1G_00855_Ccin ------------------------------------------------------------ CC1G_00325_Ccin ------------------------------------------------------------ NDR2_Mmus ------------------------------------------------------------ NDR1_Mmus ------------------------------------------------------------ NDR1_Hsap ------------------------------------------------------------ NDR2_Hsap ------------------------------------------------------------ sax-1_Cele ------------------------------------------------------------ trc_Dmel ------------------------------------------------------------ CBK1_Scer ---------------------------------------QSLQEHLQRETGNLGSGFTDV NDR_Spur ------------------------------------------------------------ CC1G_01990_Ccin EIVPPANAAIKATPKKGRRVSKDMVSKPTGFVHLVHASDADQYEALLTRWGPDGIGKLGD CC1G_00855_Ccin ------------------------------------------------------------ CC1G_00325_Ccin ------------------------------------------------------------ NDR2_Mmus ------------------------------------------------------------ NDR1_Mmus ------------------------------------------------------------ NDR1_Hsap ------------------------------------------------------------ NDR2_Hsap ------------------------------------------------------------ sax-1_Cele ------------------------------------------------------------ trc_Dmel ------------------------------------------------------------ CBK1_Scer PALNYPATP--PPHNNYAASNQMINTPPPSMGGLYRHNNNSQSMVQNGNGSGNAQLPQLS NDR_Spur ------------------------------------------------------------ CC1G_01990_Ccin PQWANPIKNRVRMLNQAKAVNEVVNACKPSQGSVYGDTTFGQLHVVNGI----------- CC1G_00855_Ccin ------------------------------------------------------------ CC1G_00325_Ccin ------------------------------------------------------------ NDR2_Mmus ------------------------------------------------------------ NDR1_Mmus ------------------------------------------------------------ NDR1_Hsap ------------------------------------------------------------ NDR2_Hsap ------------------------------------------------------------ sax-1_Cele ------------------------------------------------------------ trc_Dmel ------------------------------------------------------------ CBK1_Scer PG------------------QYSIESEYNQNLNG-SS--------SSSPFHQPQTLRSNG NDR_Spur ------------------------------------------------------------ CC1G_01990_Ccin -SSATSSSLTTGAIENMSIGPYRYDGL-PQRWGGGSTLRKATGGLQTHP----------- CC1G_00855_Ccin ------------------------------------------------------------ CC1G_00325_Ccin ---------------------------------------------SRV------------ NDR2_Mmus ------------------------------------------------------------ NDR1_Mmus ------------------------------------------------------------ NDR1_Hsap ------------------------------------------------------------ NDR2_Hsap ------------------------------------------------------------ sax-1_Cele ------------------------------------------------------------ trc_Dmel ------------------------------------------------------------ CBK1_Scer SYSSGLRSVKSFQRLQQEQENVQVQQQLSQAQQQNSRQQQQQLQYQQQQQQQQQQQHMQI NDR_Spur ------------------------------------------------------------ CC1G_01990_Ccin ----------------------------------------------------------EV CC1G_00855_Ccin ------------------------------------------------------------ CC1G_00325_Ccin ------------------------------------------------------------ NDR2_Mmus ------------------------------------------------------------ NDR1_Mmus ------------------------------------------------------------ NDR1_Hsap ----------------------S------------TPCSSMSNHTKERVTMTKVTLENFY NDR2_Hsap ----------------------T------------TTTFPMSNHTRERVTVAKLTLENFY sax-1_Cele ----------------------------------------ISQYTKDKASCTRISIESYY trc_Dmel ---------------------AD------------GASIRFSDHTLDKATKAKVTLENYY CBK1_Scer QQQQQQQQQQQQSQSPVQSGFNNGT-ISNYMYFER-RPDLLTKGTQDKAAAVKLKIENFY NDR_Spur ----------------------Y------------G-----TTYTQDKVTKAKVTLESFY CC1G_01990_Ccin ------YEGQDRGASPVMDLPP---------PPP-AKPIIPSLTTLEKAVAARIYFENIY CC1G_00855_Ccin ---------------------GTIQRPDDYVYFE-RSTAKFSSDAVARATAAKLKLESYY CC1G_00325_Ccin ---NINQSRQPSGPSPAATAQGAAK-SPDYVYFDRNPSTCFSEESQIRAKSAQLKLENYY NDR2_Mmus ----------------------A------------TTTFPMSNHTRERVTVAKLTLENFY NDR1_Mmus ----------------------S------------TPCSSMSNHTKERVTMTKVTLENFY : : :. .:: :*. * NDR1_Hsap SNLIAQHEEREMRQKKLEKVMEEEGLK-DEEKRLRRSAHARKETEFLRLKRTRLGLEDFE NDR2_Hsap SNLILQHEERETRQKKLEVAMEEEGLA-DEEKKLRRSQHARKETEFLRLKRTRLGLDDFE sax-1_Cele SKRVTQCAERENRLKKLEEDISARGLS-DEEKEEKRKIHHSKETDYLRLKRTRLTVNDFE trc_Dmel SNLVTQYGERKQRLAKLEAQLKDESLS-EAQRQEKRLQHAQKETEYLRLKRLRLGVEDFE CBK1_Scer QSSVKYAIERNERRVELETELTSHNWS-EERKSRQLSSLGKKESQFLRLRRTRLSLEDFH NDR_Spur SNLWMQKEERLTRQKKLEDAIA--GLP-EEDKREKRTQHAQKETEFLRLKRSRLGCDDFE CC1G_01990_Ccin FSLFRHVPSREQRRLAMERDMAAMGLD-SAQKEILRARWRQNETEYLRQTRQKLDASAFI CC1G_00855_Ccin KMAVDSAIERNARRIEMETRLTQLHTQ-DAKDREIR-KYSKTESQHLRLRRTKIKLSDFK CC1G_00325_Ccin KVAVESAVERNARRVELERRLQEDTLISDSRKNRQLQQLGKKESTFLRLRRTKIGLNDFR NDR2_Mmus SNLILQHEERETRQKKLEVAMEEEGLA-DEEKKLRRSQHARKETEFLRLKRTRLGLDDFE NDR1_Mmus SNLIAQHEEREMRQKKLEKVMEEEGLK-DEEKRLRRSAHARKETEFLRLKRTRLGLEDFE .* * :* : . .*: .** * :: . * NDR1_Hsap SLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD----- NDR2_Hsap SLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVAHIRAERDILVEAD----- sax-1_Cele SLKVIGRGAFGEVRLVQKHDTGHIYAMKILRKSEMVEKEQTAHVRAERDILSEAD----- trc_Dmel ALKVIGRGAFGEVRLVQKKDTGHVYAMKVLRKADMLEKEQVAHVRAERDVLVEAD----- CBK1_Scer TVKVIGKGAFGEVRLVQKKDTGKIYAMKTLLKSEMYKKDQLAHVKAERDVLAGSD----- NDR_Spur SIKVIGRGAFGEVRLVQKKDTGHIYAMKILRKCDMHEKEQVAHVRAERDILVEAD----- CC1G_01990_Ccin KLKTIGHGAFGVVSLVKEKSSGNLYAMKQMRKADMLRKGQEGHVRAERDILKSASLVHSP CC1G_00855_Ccin TVKVIGKGAFGEVRLVQKVDTGKVYAMKSLQKAEMLKRDQLAHVRAERDVLAEST----- CC1G_00325_Ccin TVKVIGKGAFGEVRLVQKTDTGKIYAMKLLRKNEMLKKDQLAHVRAERDVLAESD----- NDR2_Mmus SLKVIGRGAFGEVRLVQKKDTGHIYAMKILRKADMLEKEQVAHIRAERDILVEAD----- NDR1_Mmus SLKVIGRGAFGEVRLVQKKDTGHVYAMKILRKADMLEKEQVGHIRAERDILVEAD----- :*.**:**** * **:: .:*::**** : * :* .: * .*::****:* : NDR1_Hsap --SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI NDR2_Hsap --GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAI sax-1_Cele --CDWVVKMYYSFQDYSNLYLVMEFLPGGDMMTLLIKKDTLTEEATQFYIAEAALAIQFI trc_Dmel --HQWVVKMYYSFQDPVNLYLIMEFLPGGDMMTLLMKKDTLSEEGTQFYISETALAIDSI CBK1_Scer --SPWVVSLYYSFQDAQYLYLIMEFLPGGDLMTMLIRWQLFTEDVTRFYMAECILAIETI NDR_Spur --NPWVVKMYYSFQDPYNLYLIMEFLPGGDMMTLLMKRETLSEEVTLFYIAETIMAINSI CC1G_01990_Ccin GGAEWIVRLHYSFQDRDNLYLILEYMGGGDLLNLLIERDIFEEDFTRFYVAEMILAIEQC CC1G_00855_Ccin --SPWVVQLFYSFQDPLYLYLIMEFLPGGDLMTMLMKYDVFSEDVTRFYMAECILAIEAV CC1G_00325_Ccin --SPWVVSLFYSFQDPTYLYLVMEFLPGGDLMTMLIKYDTFSEDVTRFYMAECVLAIEAV NDR2_Mmus --GAWVVKMFYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAI NDR1_Mmus --SLWVVKMFYSFQDKLNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYIAETVLAIDSI *:* :.***** ***::*:: ***::.:*:. : : *: * **::* :**: NDR1_Hsap HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLP-SDFT---- NDR2_Hsap HQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPP-SDFS---- sax-1_Cele HSLGFIHRDIKPDNLLLDARGHVKLSDFGLCTGLKKFHRTDHYRNWPSTLP-PDFI---- trc_Dmel HKLGFIHRDIKPDNLLLDARGHLKLSDFGLCTGLKKSHRTDFYRDLSQAKP-SDFIGT-- CBK1_Scer HKLGFIHRDIKPDNILIDIRGHIKLSDFGLSTGFHKTHDSNYYKKLLQQDEATNGISKPG NDR_Spur HKLNFIHRDIKPDNLLLDARGHIKLSDFGLCTGLKKSHRTEFYRDLSQVRP-NDFSAT-- CC1G_01990_Ccin HKHGFIHRDIKPDNFLFDPEGHIKLNYEQQ-----RLHLLHKYGIDLE-DP-NGI----- CC1G_00855_Ccin HNLGYIHRDIKPDNVLIDRNGHLKLSDFGLSTGLHKATDGEIYKRYLEQEKTKDNSRN-- CC1G_00325_Ccin HRMGFIHRDIKPDNILIDKDGHIKLSDFGLSTGFHKQHDSSYYQRLLESAK-NSSNNTP- NDR2_Mmus HQLGFIHRDVKPDNLLLDAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPP-SDFS---- NDR1_Mmus HQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCTGLKKAHRTEFYRNLNHSLP-SDFT---- * .:****:****.*:* **:**. : * . NDR1_Hsap --------------------------FQNMNSKRKAETWKR-NRRQLAFSTVGTPDYIAP NDR2_Hsap --------------------------FQNMNSKRKAETWKK-NRRQLAYSTVGTPDYIAP sax-1_Cele --------------------------SKPFESKRKAETWKR-NRRAYAYSTVGTPDYIAP trc_Dmel -------------------------CASPMDSKRRAESWKR-NRRALAYSTVGTPDYIAP CBK1_Scer TYNANTTDTANKRQTMVVD-----SISLTMSNRQQIQTWRK-SRRLMAYSTVGTPDYIAP NDR_Spur -------------------------TCKPMDSKRLAESWKR-NRRALAYSTVGTPDYIAP CC1G_01990_Ccin ---------ADGRKTKRLDPKQIELLMGGGDGKTGIFTWREKNKRK-------------- CC1G_00855_Ccin --------------SVQVN-----PINLT-MSREQIATWKA-NRRKLAYSTVGTPDYIAP CC1G_00325_Ccin ---------QSSRNSVMVN-----SINLT-ISNQDIATWKA-NRRKLAYSTVGTPDYIAP NDR2_Mmus --------------------------FQNMNSKRKAETWKK-NRRQLAYSTVGTPDYIAP NDR1_Mmus --------------------------FQNMNSKRKAETWKR-NRRQLAFSTVGTPDYIAP .. :*: .:* NDR1_Hsap EVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPISE NDR2_Hsap EVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPISE sax-1_Cele EVFQPNGYTKSCDWWSLGVIMYEMLIGYPPFCSELPQETYRKVINWQQTLVFPSDVPISI trc_Dmel EVFLQTGYGPACDWWSLGVIMYEMLMGYPPFCSDNPQDTYRKVMNWRETLIFPPEIPISE CBK1_Scer EIFLYQGYGQECDWWSLGAIMYECLIGWPPFCSETPQETYRKIMNFEQTLQFPDDIHISY NDR_Spur EVFLQTGYSHVCDWWSLGVVMYEMLIGYPPFCSETPQETYRKVMHWRETLQFPAEIPISN CC1G_01990_Ccin -----------------------------------RHVTRQKILNWKQSLRFPSRPRVSP CC1G_00855_Ccin EVFMMKGYGKECDWWSLGAIFFECLVGYAPFCSDNPGDTYKKIIDWPRYLIFPEEVYISK CC1G_00325_Ccin EIFLQKGYGKECDWWSLGAIMFECLVGYPPFCSESTHETYQKIIHWRHCLSFPSDIHLSA NDR2_Mmus EVFMQTGYNKLCDWWSLGVIMYEMLIGFPPFCSETPQETYRKVMSWKETLAFPPEVPVSE NDR1_Mmus EVFMQTGYNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYKKVMNWKETLTFPPEVPVSE * :*:: : . * ** :* NDR1_Hsap KAKDLILRFCC--------------------EWEHRIGA-PGVEEI-------------- NDR2_Hsap KAKDLILRFCI--------------------DSENRIGN-SGVEEI-------------- sax-1_Cele EAKATIKRFCC--------------------EAERRLGNHGGLDEI-------------- trc_Dmel EAKETIINFCC--------------------EADRRLGSQRGLEDL-------------- CBK1_Scer EAEDLIRRLLT--------------------HADQRLGRHGGADEI-------------- NDR_Spur EAKGMIQRFCC--------------------EADRRVGK-NGVDEI-------------- CC1G_01990_Ccin EGVNLMQQLLC--------------------EPEDRLGSQ-ASSSVFRPDSLVVQARRSG CC1G_00855_Ccin EGEDLIRGYVRLIYYLLGHLNLTLFVLSMMNWADKRL----TVEQI-------------- CC1G_00325_Ccin EALDLIQRMIT--------------------SADQRL----NVDQI-------------- NDR2_Mmus KAKDLILRFCT--------------------DSENRIGN-GGVEEI-------------- NDR1_Mmus KAKGLILRFCC--------------------EWEHRIGA-PGVEEI-------------- :. : : *: ..: NDR1_Hsap -------------------------------------KSNSFFEGVDWEHIRERPAAISI NDR2_Hsap -------------------------------------KGHPFFEGVDWEHIRERPAAIPI sax-1_Cele -------------------------------------KQCPFVKRIDWNHIRERPPPIRV trc_Dmel -------------------------------------KSVPFFRGVDWEHIRERPAAIPV CBK1_Scer -------------------------------------KSHPFFRGVDWNTIRQVEAPYIP NDR_Spur -------------------------------------KSHAFFHGVDWEHIRERPAAIPT CC1G_01990_Ccin FMPQAGSTTSVDGAHLIKVRSPLHSPSNVASRSRLVEQAHPWFKGIDWDNIHKYPAPYRP CC1G_00855_Ccin -------------------------------------KNHPWFFGADWNSLRYIEPPFVP CC1G_00325_Ccin -------------------------------------KRHPFFYGVDWATIRQIDAPFVP NDR2_Mmus -------------------------------------KGHPFFEGVDWGHIRERPAAIPI NDR1_Mmus -------------------------------------KNNLFFEGVDWEHIRERPAAISI : :. ** :: .. NDR1_Hsap EIKSIDDTSNFDE-FPESDILKPTVATSN-H--------------P-ETDYKNKDWVFIN NDR2_Hsap EIKSIDDTSNFDD-FPESDILQPVPNT------------------T-EPDYKSKDWVFLN sax-1_Cele TVKSIDDTSNFDD-FPDEDLTWPTSTLI--R--------------P-E-EQPGRRGEFVD trc_Dmel EVRSIDDTSNFDE-FPDVSLEIPSAPI------------------P-QGGEIAKDWVFIN CBK1_Scer KLSSITDTRFF----PTDELENVPDSPAMAQAAKQREQMTK---QG-GSAPVKEDLPFIG NDR_Spur NIKSFEDTSNFDA-FPEIEL-KPITPP------------------Q-ATGEHMKDWVFIN CC1G_01990_Ccin ELTSPDDTRHFDSDIPPEPL-APANGAPP-DATR--DPMLKDKVHGEDILNVRKALAFAG CC1G_00855_Ccin RLSSITDTSYF----PTDDLGNVSNQLDQ----------------V-ESVSAEKDLAFLG CC1G_00325_Ccin RLSSITDTSYF----PTDEIDQVTDDIPQ------------------DASSADKDLAFLG NDR2_Mmus EIRSIDDTSNFDD-FPESDILQPVPNT------------------T-EPDYKSKDWVFLN NDR1_Mmus EIKSIDDTSNFDE-FPESDILKPTVTTSS-H--------------P-ETDYKNKDWVFIN : * ** * * : . * . NDR1_Hsap YTYKRFEGLTAR----------------------GAIPSYMK------------AAK NDR2_Hsap YTYKRFEGLTQR----------------------GSIPTYMK-----------AGKL sax-1_Cele FTYKRFDGLTQK----------------------MRYSDLKKQAKKNKKGGQQGTSD trc_Dmel YTYKRFEVR---------------------------------------------NLE CBK1_Scer YTYSRFDYLTR------------------------------------------KNAL NDR_Spur YTFKRFEGLTQR----------------------GMGQRQST-----------SLIR CC1G_01990_Ccin FTHKSPRAIEYVRVDRAFDPMPTPRGGGHEDALRGRSPVRET--R--TIGKGRAISL CC1G_00855_Ccin FTFKRFTGGP-------------------------------------------GASG CC1G_00325_Ccin YTFKRFSIS--------------------------------------------SHAF NDR2_Mmus YTYKRFEGLTQR----------------------GSIPTYMK-----------AGKL NDR1_Mmus YTYKRFEGLTAR----------------------GAIPSYMK------------AAK :*..