CLUSTAL W (1.83) multiple sequence alignment NEK2_Hsap MPS------------------RAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYG NEK2_Mmus MPS------------------RVEDYEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYG Nek2_Ddis ----------------------MDQYEILGALGKGSFGVVSKIKRKEDGRVLVWKEICYE Nek2_Dmel MSGEES------AGMD-FSQKTLQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYD KIN3_Scer MHRRQFFQEYRSPQQQQGHPP-RSEYQVLEEIGRGSFGSVRKVIHIPTKKLLVRKDIKYG NEK2_Spur MPS------------------KLSDYDILYTIGSGSYGKCRKVRRKSDGKILVSKEIDYG CC1G_04175_Ccin MSA------------------FLEQYEPLDVIGNGSFGIIRKVRRKSDGLIFARKELNFE AqueK179_Aque MPS-----------------GKLDDYVVVGMIGSGSFGQCKKIRRICDGKVLVWKEINYK .:* : :* **:* *: ::. * : : NEK2_Hsap SMTEAEKQMLVSEVNLLRELKHPNIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGT NEK2_Mmus SMTEVEKQMLVSEVNLLRELKHPNIVSYYDRIIDRTNTTLYIVMEYCEGGDLASVISKGT Nek2_Ddis NMQEKEKQLLVNEVNILQKLKHQNIVRYYDRIIDKPSSRLYIIMEHCSGGDLSQLIKKCR Nek2_Dmel ELDEAKCDALVSEISVLRQLQHPNIVQYYHHLVNREAKSVYIVMECCAGGDLAQIVQRAR KIN3_Scer HMNSKERQQLIAECSILSQLKHENIVEFYNWDFDEQKEVLYLYMEYCSRGDLSQMIKHYK NEK2_Spur TMGEVEKQMLVSEVNLLRELKHEFIVRYYDRIVDRATSTIYIIMEYCEGGDLGSLISKCK CC1G_04175_Ccin RMSERDRKQIVAEVNILKDLHHEHIVRYHDRHVDRDAGILYIIMEYCGGGDLSTVIKQAA AqueK179_Aque EMTESEKQQLVTEVNLLRELKHTHIVQYYDRIIDRSQSMLYIITEYCPGGDLATLISQHR : . . . :: * .:* .*:* ** ::. .:. :*: * * ***. :: : NEK2_Hsap KERQYLDEEFVLRVMTQLTLALKECHRRSD---------------G-G------------ NEK2_Mmus KDRQYLEEEFVLRVMTQLTLALKECHRRSD---------------G-G------------ Nek2_Ddis NERTYMDEEVIWRTLLQILSALQEIHNRKD------------------------------ Nek2_Dmel SQRQRFEEPYIWRVLFQLCRALQVCHNKIP---------------N-------------- KIN3_Scer QEHKYIPEKIVWGILAQLLTALYKCHYGVELPTLTTIYDRMKPPVKGK------------ NEK2_Spur KDRKFLEESFAWKIFQQLTIALQECHRRGK-----------------G------------ CC1G_04175_Ccin KHNRPISEDLIWNYFMQILLALHHCHHPNG---------------H-GRSGSGSGSALTE AqueK179_Aque HQRKLLPECFIWQVMHQILLALEECHRSKE---------------NVG------------ .. : * : *: ** * NEK2_Hsap ---------HTVLHRDLKPANVFLDGKQ-------------------------------- NEK2_Mmus ---------HTVLHRDLKPANVFLDSKH-------------------------------- Nek2_Ddis ---------GVILHRDIKPGNLFLDENK-------------------------------- Nek2_Dmel ---------GTILHRDIKPANIFLDAAG-------------------------------- KIN3_Scer ---------NIVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNSNYYRDHRVNSGKRGS NEK2_Spur ---------RAILHRDLKPANVFLDADH-------------------------------- CC1G_04175_Ccin GEGGGSSRRPQILHRDLKPDNVFLDENN-------------------------------- AqueK179_Aque ---------GKVMHRDIKPANVFLDGEG-------------------------------- ::***:** *:**. NEK2_Hsap -------NVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNEKSDIWSLGCLL NEK2_Mmus -------NVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMSCLSYNEKSDIWSLGCLL Nek2_Ddis -------NIKLGDFGLAKILN-ESLYAHTFVGTPYYMSPEQIHGLKYNERSDVWSVGCLI Nek2_Dmel -------NAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDVWAVGCLV KIN3_Scer PMDYSQVVVKLGDFGLAKSLETSIQFATTYVGTPYYMSPEVLMDQPYSPLSDIWSLGCVI NEK2_Spur -------NVKLGDFGLARVLQHDTSFAKTFVGTPYYMSPEQMNRLSYNDKSDIWSLGCLL CC1G_04175_Ccin -------NVKLGDFGLSKALN-QASFANTYVGTPYYMSPELMQEKAYDSKSDIWSLGCLI AqueK179_Aque -------QVKLGDFGLARILH-NTSLAKTFVGTPYYMSPEQYSCNSYDHRSDLWSIGCLL *******:: *. . * ::****:***** *. **:*::**:: NEK2_Hsap YELCALMPPFT-AFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRPSVEEI NEK2_Mmus YELCALMPPFT-AFNQKELAGKIREGRFRRIPYRYSDGLNDLITRMLNLKDYHRPSVEEI Nek2_Ddis YEMATLSPPFE-ATNQAQLTSKIQVGRYNPIPSQYSEHLSKVISLMINVDPKSRPNVNEL Nek2_Dmel YEMCALRPPFR-GRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEVI KIN3_Scer FEMCSLHPPFQ-AKNYLELQTKIKNGKCDTVPEYYSRGLNAIIHSMIDVNLRTRPSTFEL NEK2_Spur YELCSLSPPFT-ATNQAALAVKIKGGHFRRLPVQYSSDLNEIVSSMLKVKPSSRPSIDEL CC1G_04175_Ccin YELCALKPPFHEAKTHNELSILIRNGRIPPLPRGYSQALFGVIKAMLNLNPAMRPSAAQL AqueK179_Aque YELCALKPPFV-ASSQYKLAEYVCNGRFSRIPSKYSDDLHWTISQLLHVKPEKRPLLSQL :*:.:* *** . * : *. :* ** * : :: :. ** : NEK2_Hsap LENPLIADL--VADE--------------------------------------------- NEK2_Mmus LESPLIADL--VAEE--------------------------------------------- Nek2_Ddis LGYSFISFK--VKE---------------------------------------------- Nek2_Dmel IRHPLVVRN--ISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQY KIN3_Scer LQDIQIRT--AR------------------------------------------------ NEK2_Spur LADPRLSPP--PSQV--------------------------------------------- CC1G_04175_Ccin LQHERLELVFKVAETE-------------------------------------------- AqueK179_Aque LSLLEEKIP--LAKP--------------------------------------------- : NEK2_Hsap -----------------------------------------------------------Q NEK2_Mmus -----------------------------------------------------------Q Nek2_Ddis -----------------------------------------------------------R Nek2_Dmel SFNEGYGQRRLSVTGVFTPDLRSELFYSAKRKIFPAKKLQLSDPSLYESIRREERA-EER KIN3_Scer -----------------------------------------------------------K NEK2_Spur -----------------------------------------SS---------ADAP-KEA CC1G_04175_Ccin ---------------------------------------KMLS-----TVK---AH-KN- AqueK179_Aque --------------------------------------PNVAG---------TEKTTPPS NEK2_Hsap RRNLERRGRQL------------------------------------------------- NEK2_Mmus RRNLERRGRRS------------------------------------------------- Nek2_Ddis KLNIYYQG---------------------------------------------------- Nek2_Dmel QVELAEERRRK---------KDQEQQ---------------------------------- KIN3_Scer SLQLER------------------------------------------------------ NEK2_Spur EVDLLKKEREA------------------------------------------------- CC1G_04175_Ccin --AMVAREREVLAREQIIAEKEQHLQHLFSQKDSEIAHLQRVVSQLQAQIHTIQSEPRIT AqueK179_Aque VLGAVKE----------------------------------------------------- NEK2_Hsap ------------------------------------------------------------ NEK2_Mmus ------------------------------------------------------------ Nek2_Ddis ------------------------------------------------------------ Nek2_Dmel ---------------------------------------------------------KRD KIN3_Scer ------------------------------------------------------------ NEK2_Spur ------------------------------------------------------------ CC1G_04175_Ccin QHDLEVATKHAVARREQELRILVQKREEEVAAAMAKREEEIMEAVRRREAEVCEAWAKRE AqueK179_Aque ------------------------------------------------------------ NEK2_Hsap GEPEKSQDSSPVLSELKLKEIQLQERERALKAREERLEQK----EQELC-VRERLAE--- NEK2_Mmus GEPSKLPDSSPVLSELKLKERQLQDREQALRAREDILEQK----ERELC-IRERLAE--- Nek2_Ddis --------LKQMDEDLKIKEKKLSDIERDLQVKEQHLLLR----EQQIN-QREKLLL--- Nek2_Dmel QELLKEAPSSPRALTQNIFDEVLKTRLHAIRAQESLLQQK----LEELQ-TREQELQLAE KIN3_Scer ------------------FERKLLDYENELTNIEKILEKQAIEYERELSQLKEQFTQAVE NEK2_Spur --------LLAREESLKLKERNADKRTQMLNDREKELDLR----ERSLA-ARERLVK--- CC1G_04175_Ccin AEVRQEVE---------VSIKAVEERIQWISEKEAELIEE----EERLE-ALREELEVRE AqueK179_Aque ------------EESLQRKLDELHRKEEILRKKEEDLQRK----EIELK-RREEVLV--- . : * * . : .. NEK2_Hsap DKLARA-ENLLKNY----SLLKERK-----------FLSL-AS----------------- NEK2_Mmus DKLARA-ESLMKNY----SLLKEHR-----------LLCL-AG----------------- Nek2_Ddis DKENFETQSRIN--IMNQQLQQQQQNQLQHQ-----I----------------------- Nek2_Dmel QRVQTL-ERQMQEK----LLQQEKHT-CSCRQPIAPPIPPRKPAKSHHDDTYCTIELNET KIN3_Scer ---ERA-REVISGK---------------------------------------------- NEK2_Spur DKMSRA-EELIEEH----EKQQKQIPKVITR-----VTEL-RR----------------- CC1G_04175_Ccin ---KRV-EELANKKGRTKSPLEEIRNTME-P----------TPQRR-------------- AqueK179_Aque ------------------------------------------------------------ NEK2_Hsap -----NPELLN-L-PSSV-IKKKVHF--------------SG------------------ NEK2_Mmus -----GPE-LD-L-PSSA-MKKKVHF--------------HG------------------ Nek2_Ddis ------S-NLSLNCNNSVNS-----C--------------SS------------------ Nek2_Dmel SPTVAKLNLATLPAPKSLNTLRKVTF--------------KS-----------PQKF--V KIN3_Scer -------KV--GKVPESINGY--------------------------------------- NEK2_Spur -----QKEYLEGMHPTTLKTKKHVHF--------------QQ------------------ CC1G_04175_Ccin -------N-YD-PPPSTIK-RNRVDSTPRATTKQMFPAALETPITRPSYTDYLPSAMKGV AqueK179_Aque ------------------------------------------------------------ NEK2_Hsap --------------------------------------ESKENIMR-SENSESQL----- NEK2_Mmus --------------------------------------ESKENTAR-SENSESYL----- Nek2_Ddis --------------------------------------SSNNNTTNS-INTQQQIH---- Nek2_Dmel ---TYG-IENMPPPA-VKPAVN-PPPTGVPMQMSVSSNDSGDSQAS-STRRKSILSLFGL KIN3_Scer ----YGKKFAK------------------------------------------------- NEK2_Spur ---------------------------------------GKENNPASHEGEPAVP----- CC1G_04175_Ccin VLTSTGETLATPSPNELATLFNASPKVGLNFGKIFDFGEGDDDVTS-PTNTTTRLSLGGA AqueK179_Aque ------------------------------------------------------------ NEK2_Hsap -----------------------------------------------TSKSKCKDLKKR- NEK2_Mmus ------------------------------------------------AKSKCRDLKKR- Nek2_Ddis ------------------------------------------------------------ Nek2_Dmel SRGSKATSKSLPSVNQVAQAAATRVQRPPLAVKPPITQEQPAEVPP-VANLWTKEQKKQA KIN3_Scer ------------------------------------------------------------ NEK2_Spur -----------------------------------------------SADSKMTNLKER- CC1G_04175_Ccin GSGLNGVGAS--GVN-------GGVQFP----NGAGSESDEDDAPPSPTTRKERELRER- AqueK179_Aque ------------------------------------------------------------ NEK2_Hsap -----------------------------LHAAQ-LRA---------------------- NEK2_Mmus -----------------------------LHAAQ-LRA---------------------- Nek2_Ddis ----------------------------IQHNTQ-QQQ---------------------- Nek2_Dmel FELLAAMNAAEREASGGGVVGSGPGGARRQHLRQ-SVR---------------------- KIN3_Scer ------------------------------------------------------------ NEK2_Spur -----------------------------LYQAK-LRG---------------------- CC1G_04175_Ccin -----------------------------AESRSSLGGGEDATVTIAMNLGSATNGASVS AqueK179_Aque ------------------------------------------------------------ NEK2_Hsap ---QALSDI------------EKNYQLK---SRQILGMR NEK2_Mmus ---QALADI------------EKNYQLK---SRQILGMR Nek2_Ddis ---QQQQT-------------FQPYQIKRTFTTPLPNFK Nek2_Dmel ---ERNSTLQRNRMRRSLVVATGHQKLT---T-RDQMVI KIN3_Scer ----------------------PAY----H---WQTRYR NEK2_Spur ---LALRKA------------EMTSKLK---SKQLLSLR CC1G_04175_Ccin TPTQASEDVYLGWVAPPYAYVGFESEVV---GDYAFGVG AqueK179_Aque --------------------------LR---EKQQAILK