CLUSTAL W (1.83) multiple sequence alignment NEK8_Hsap ------------------------------------------------------------ NEK8_Mmus ------------------------------------------------------------ Y39G10AR.4_Cele MSTVILCHAESVNLDTIRASDANIIRYSVGVKMTELKDMLKQYTAGRIRNLGLHIQTRDT ZC581.1_Cele ------------------------------------------------------------ CG10951_Dmel MKKFR-AKASSLPIFNGRITDATTLTTSSLQLPLGQNTQRKQSTC--------------- Nek8b_Spur ------------------------------------------------------------ NEK8a_Spur ------------------------------------------------------------ AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque MLQFC-AG---------------------------------------------------- AqueK183_Aque ------------------------------------------------------------ NEK8_Hsap ------------------------------------------------------------ NEK8_Mmus ------------------------------------------------------------ Y39G10AR.4_Cele KLRILEDMEVTKESLENAGSFVSQFFRWLISEVLIEGAFIDFLLTTPIENASQICLAV-Q ZC581.1_Cele ------------------------------------------------------------ CG10951_Dmel -TRVLPTV---------------------------------FTITDGTTGAASTSLAEAM Nek8b_Spur ------------------------------------------------------------ NEK8a_Spur ------------------------------------------------------------ AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque ---------------------------------------------------------F-F AqueK183_Aque ------------------------------------------------------------ NEK8_Hsap ------------------------------------------------MEKYERIRVVGR NEK8_Mmus ------------------------------------------------MEKYERIRVVGR Y39G10AR.4_Cele SVSKKKISVRLVSRFLSSELAPHNRRIVEIYINNEIMITNPNPRATSAQNRYERIRTVGK ZC581.1_Cele ------------------------------------------------MDNYEKVRVVGR CG10951_Dmel SSSKAQMPNR-------------QESLLQLSVPRETGVGVAG----PELANYEKVRVVGQ Nek8b_Spur ------------------------------------------------------------ NEK8a_Spur ------------------------------------------------MEQYEKIKVVGR AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque NVGTKLYKVSVYTDIWGSPVD-GGEKIGTLFFDGQKLKEWNAPTL-MKLEKYERIKTVGK AqueK183_Aque ------------------------------------------------MERYEKIRVIGQ NEK8_Hsap GAFGIVHLCLRKADQ--KLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENF NEK8_Mmus GAFGIVHLCLRKADQ--KLVILKQIPVEQMTKEERQAAQNECQVLKLLNHPNVIEYYENF Y39G10AR.4_Cele GAFGSAVLYRRREDS--SLVIIKEINMYDLDSSQRRLALNEVSLLSRIEHPNIIAYYDSF ZC581.1_Cele GAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQSEVNLLKKVQHPLIIGYIDSF CG10951_Dmel GSFGIAILYRRKSDG--HQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYLGSF Nek8b_Spur --------------------------MHELNANERQMALNEIRVLSMLDHPNIISYYDSF NEK8a_Spur GAFGTVYLCRRLHDM--KLIIIKQIPX--------------------------------- AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque GAYGQAILYKRKEDE--SLVILKQINILELNKIERQNVVTEIKILAMLDHPHIISYYDNF AqueK183_Aque GAFGKVFLCKNLGNN--NHVVIKQIPVDELPSEERKSAMNEVNVLSMLQHPNIIGYYASF NEK8_Hsap LEDKALMIAMEYAPGGTLAEFIQKRC-------NSLLEEETILHFFVQILLALHHVHTHL NEK8_Mmus LEDKALMIAMEYAPGGTLAEFIQKRC-------NSLLEEETILHFFVQILLALHHVHTHL Y39G10AR.4_Cele EEEGVLMIEMEYADGGTLAQMLSRT-Q-------NLLDEEQIGDMMIQMCSAVAYLHENS ZC581.1_Cele IMDNQLGIVMQYAEGGTLERLINDQRAIKDSNMREYFPEKTVLDYFTQILIALNHMHQKN CG10951_Dmel IKDNTLLIEMEYADGGTLAQIIAERQG------KLHFPERYIIAVFEQISSAINYMHSEN Nek8b_Spur EEEGTLMIEMEYADGGTLAEYLASNQG------KSEMEEREILIMFQQMVSGIRHVHDHM NEK8a_Spur ------------XXGGTVFEYLQQRG-------NALIEEDEVLRLMAQILLSMKHVHSKQ AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque EEDGLMMIEMEFADGGYKANLIKYC-S-------AM------------------------ AqueK183_Aque VEDKSLMIAMEYAPGGTLYELIQERN-------GKHIEEETILQLFVQILVAIEHVHSLN NEK8_Hsap ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSK---SKAYTVVGTPCYISPELCEGKPY NEK8_Mmus ILHRDLKTQNILLDKHRMVVKIGDFGISKILSSK---SKAYTVVGTPCYISPELCEGKPY Y39G10AR.4_Cele VLHRDLKTANVFLTRD-SFVKIGDFGISKIMGTETLAQGAKTVVGTPYYISPEMCSGVSY ZC581.1_Cele IVHRDLKPQNILMNRRKTVLKLSDFGISKELGTK---SAASTVIGTPNYLSPEICESRPY CG10951_Dmel ILHRDLKTANVFLNRR-GIVKIGDFGISKIMNTK---IHAQTVLGTPYYFSPEMCEGKEY Nek8b_Spur ILHRN------------------------------------------CMICPLQCEGKPY NEK8a_Spur ILHRDLKTQNILLNRDCDVIKIGDFGISKILSSK---SKAFTVVGTPSYISPELCEGKPY AqueK181_Aque ----DLKTANIFLTRH-GIVKLGDFGISKVLSGTH--QAADSIVGTPYYISPEICEGKQY AqueK182_Aque ------------------------------------------------------------ AqueK183_Aque ILHRDLKPQNIMLNKKKTVVKIGDFGISKVLSSKI--TSAQTVVGTPCYISPEICEGRVY NEK8_Hsap NQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGT--FAPISDRYSPELRQLVLSL NEK8_Mmus NQKSDIWALGCVLYELASLKRAFEAANLPALVLKIMSGT--FAPISDRYSPELRQLVLSL Y39G10AR.4_Cele NEKSDMWALGCILYEMCCLKKAFEGDNLPALVNSIMTCA--YTPVKGPYSAEMKMVIREL ZC581.1_Cele NQKSDMWSLGCVLYELLQLERAFDGENLPAIVMKITRSK--QNPLGDHVSNDVKMLVENL CG10951_Dmel DNKSDIWALGCILGEMCCLKKTFAASNLSELVTKIMAGN--YTPVPSGYTSGLRSLMSNL Nek8b_Spur NGKSDIWALGCILYEMACRQKTFEGTNLPALVNKIMKVGH-KGPNSQR--PRVQVFVQDM NEK8a_Spur NQKSDMWAIGCVLYELLTLRRAFEANNLPALVMKIMRGS--VAPISDRYSDQLKRLLLRM AqueK181_Aque NSKSDIWSLGCILHEMMCLSRPFDGTNLPALVHKIVEGS--FDPIKGKYSDELKQLVS-- AqueK182_Aque -----------------------------------------------------AGI---- AqueK183_Aque RKKSDIWSLGCILYELLALRKAFEGPNFPALVLKIMQGSNALQPLSDNYTSSLCTLVHAM . NEK8_Hsap LSLEPAQRPPLSHIMAQ--PLCIRALLNL-----HTDVGS---VRMRR---PVQG-QRAV NEK8_Mmus LSLEPAQRPPLSHIMAQ--PLCIRALLNI-----HTDVGS---VRMRR---PGPFVFRR- Y39G10AR.4_Cele LQLDPQKRPSAPQALKM-----------------------------LR---P-------- ZC581.1_Cele LKTHTDKRPDVSQLLSD--PLVLPYLISI-----HCDLGR---IE--P------------ CG10951_Dmel LQVEAPRRPTASEVLVYWIPLIFRSLGKNKGYSYEDDVGGPGSDQLTA---PV------- Nek8b_Spur LQRKPEYRPSANALDFNHIPVLMEKFIDL-----TTDVDD---EL-AA---S-------- NEK8a_Spur LHLDPDKRPTIDQVMAE--PIIFKAVIEV-----CMTMGA---VKVHPKTHPILS-S--- AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque ------------------------------------------------------------ AqueK183_Aque LQRNPDDRPNIENIMAN--PVIVNALVNL-----GTDVGR---LPCVT---PA------- NEK8_Hsap LGGRVWAPSGSTGGPHLSCRAEKSVAPSNTGSRTTSVRCRG-IPRGPVRPAIPPPLSSVY NEK8_Mmus --------------AEKSLTPGPPIASGSTGSRATSARCRG-VPRGPVRPAIPPPLSSVY Y39G10AR.4_Cele -------S-EN-------------------RHRHTSGSMRS-SV-------SFTTLYDLH ZC581.1_Cele -------PPTD----------------KRKPSASLSSRLRT-YPTQSTL--RPYSLSS-- CG10951_Dmel --------P-AAAYSNVSMELELPTAQTETKQ--LMIADT-AAPHEI-LE-KRSVLYQLK Nek8b_Spur -------TD------------------SSHRKRTRSVLYQI----DTSLPG--------- NEK8a_Spur -----RPPTGN---QR-------RSASRVSSARSSSHRCNG-SG---GLP-KPRPLSLIY AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque ------------------------------------------------------------ AqueK183_Aque ---------KSAGKRHLSLETRHG---QPGKYRQVSFFVDSYLPAAT-KEVQSSTRPLVY NEK8_Hsap AWGGGLG-TPLRLPM--LNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPG- NEK8_Mmus AWGGGLS-SPLRLPM--LNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGTLLPG- Y39G10AR.4_Cele VPTITLSSIP---DLPS-RISIKQVALSKTHTMVLTNDNELFGFGDNSCGQLGFGKF--S ZC581.1_Cele ------------------------------------------------------------ CG10951_Dmel AFGTCFSMAPIQL--PP-KAVIVDVAMSDSHFVVVNEDGSAYAWGEGTHGQLGLTAL--E Nek8b_Spur -----IPPIPFKIELPT-ILKIRQVAVSRTHIALVTYERVVYSWGEGSKGQLGHGDL--D NEK8a_Spur CWGNGIP-SPLRLPLPHADTKVLQVSIGRSQKTGVTHNGRLIIWESPSIGTDSG--LPG- AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque ------------------------------------------------------------ AqueK183_Aque LWGGSLS-VPMILPQPA-EKSVTSLSVGRSHRAAITDDGKLLFWELASGSLGGTTQFSLS NEK8_Hsap -AVEQPQP-QFISRFLEGQSG-VTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSL NEK8_Mmus -AVELPQP-QFVSRFLEGQSG-VTIKHVACGDLFTACLTDRGIIMTFGSGSNGCLGHGNL Y39G10AR.4_Cele -------K-MENGRLVESLKG-RDIQSVGVGNYFSVICCDRGTLLTFGTAKNLGLGKD-A ZC581.1_Cele ------------------------------------------------------------ CG10951_Dmel ------A-WKHYPSRMESVRN-YHVVSACAGDGFTILVTQAGSLLSCGSNAHLALGQDEQ Nek8b_Spur -------P-RNVPTSVEALKG-KSITRVACGAGFSVFGSDNGIVMTCGDGSTGCLGHGDY NEK8a_Spur -AVDQVVP-LYIPRYLEGQSA-VSIQNVSCGDLFVACLTDRGILMTFGSGAHGCLGHGNY AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque ------------------------------------------------------------ AqueK183_Aque SRARVKDPIIFQPQLVEGFSASVVIKKVSCGDLFTACLTDKGILMTFGSGINGCLGHGDY NEK8_Hsap TDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRE-SHSCPQ NEK8_Mmus TDISQPTIVEALLGYEMVQVACGASHVLALSTDGELFAWGRGDGGRLGLGTRE-SHNCPQ Y39G10AR.4_Cele KDSAKPMLLEQLLRYLF------------------------------------------- ZC581.1_Cele ---NAPTT-------HLTQLTPMPSH-----IDSGFFSSGRTSNQRTQSRS--------- CG10951_Dmel RNYHSPKLIARLADVRVEQVAAGLQHVLALSREGAVYVWGTSTCGALGLGNYQQQQKFPQ Nek8b_Spur HSASRPRLIETLLSVDVTSISCGPEHVVGVGVDGEIFAWGKGKDGRLGLGDE-------- NEK8a_Spur QDLSQAKIVEALLGYEVALVSCGASHVMAVTNEHEVFSWGRGDNGRLGLDSQE-SVSSPQ AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque ------------------------------------------------------------ AqueK183_Aque DDVPKAKLVRAMLQYETIDVACGANHVVAVTADHTVHSWGRNENGQLGTGDTL-ACNEPK NEK8_Hsap QVPMPPGQE------------AQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLG NEK8_Mmus QVPVAPGQE------------AQRVVCGIDSSMILTSPGRVLACGSNRFNKLGLDHLSLD Y39G10AR.4_Cele ------------------------------------------------------------ ZC581.1_Cele ------------------------------------------------------------ CG10951_Dmel KILLSHVK-----------TKPSKIYCGPDTSAVLFANGELHVCGSNDYNKLGFQRSA-- Nek8b_Spur ------------------------------------------------------------ NEK8a_Spur AVVLPPQHR------------ARSVCCGVDCSMLITEEGVVIACGSNRCNKLGLDQGE-- AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque ------------------------------------------------------------ AqueK183_Aque QVLPVEGEEGGGEGGGGGKEVISSVTCGSDCSILLTSNGDILCTGSNRHNKLCLDHTSVA NEK8_Hsap EEPVP-----------------------------------------------------HQ NEK8_Mmus EEPVP-----------------------------------------------------YQ Y39G10AR.4_Cele ------------------------------------------------------------ ZC581.1_Cele ------------------------------------------------------------ CG10951_Dmel ------------------------------------------------------------ Nek8b_Spur ------------------------------------------------------------ NEK8a_Spur -----------------------------------------------------------Q AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque ------------------------------------------------------------ AqueK183_Aque -TPTPATPPDFTQTSRILSSLFQAINTKESASTSQSDSRAKPRSLLATKSSTFDQSDCPD NEK8_Hsap QVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG-S NEK8_Mmus QVEEALSFTPLGSAPLDQEPLLCVDLGTAHSAAITASGDCYTFGSNQHGQLGTSSRRV-S Y39G10AR.4_Cele ------------------------------------------------------------ ZC581.1_Cele ------------------------------------------------------------ CG10951_Dmel ------KITAFKKVQLPH-KVTQACFSSTHSVFLVEGGYVYTMGRNAEGQRGIRHCNS-V Nek8b_Spur ------------------------------------------------------------ NEK8a_Spur QIEEVFSLTQVATHPLPQLNITSAAIGTSHSAFITDKGECYTLGSNQFGQLGCRTETTTP AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque ------------------------------------------------------------ AqueK183_Aque HMERVLNFTRCKVEILEG-EVTAIAAGTNHTAFINKKGHCITSGSNAYGQLGHSHSVP-A NEK8_Hsap RAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRP---- NEK8_Mmus RAPCRVQGLEGIKMVMVACGDAFTVAVGAEGEVYSWGKGTRGRLGRRDEDAGLPRP---- Y39G10AR.4_Cele ------------------------------------------------------------ ZC581.1_Cele ------------------------------------------------------------ CG10951_Dmel DHPTLVDSVKSRYIVKANCSDQCTIVASEDNIITVWGT-RNGLPGIGSTNCGLGLQICTP Nek8b_Spur ------------------------------------------------------------ NEK8a_Spur RIPCKPSFPDDVTLTQVACGDMFTVAITTDDKVFSWGKGARGRIGRPLQDTSAPRQ---- AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque ------------------------------------------------------------ AqueK183_Aque VVPK------LVSVTRISCGDNFTIAAIKDGRMYSWGCGRRGRLGYESEPIRAEPT---- NEK8_Hsap -----------------------------------------------VQLDETHPYTVTS NEK8_Mmus -----------------------------------------------VQLDETHPYMVTS Y39G10AR.4_Cele ------------------------------------------------------------ ZC581.1_Cele ------------------------------------------------------------ CG10951_Dmel NMELELGNNTAAFTNFLASVYKSELILEPVDILALFSSKEQCDRGYYVQVHDVYPLAHSV Nek8b_Spur ------------------------------------------------------------ NEK8a_Spur -----------------------------------------------VRLVDQ-DINVLS AqueK181_Aque ------------------------------------------------------------ AqueK182_Aque ------------------------------------------------------------ AqueK183_Aque ------------------------------------------------LMTFENTQTVQS NEK8_Hsap VSCCHGNTLLAVRSVTDEPVPP NEK8_Mmus VSCCHGNTLLAVRSVTDEPVPP Y39G10AR.4_Cele ------------GFHY---TNY ZC581.1_Cele -------------QVH---SKY CG10951_Dmel LVLVDTTTPLIS-SYEGDYPHL Nek8b_Spur -------------------EDL NEK8a_Spur VSCSHSNTIIASKYVE---NEA AqueK181_Aque --------------------GE AqueK182_Aque -------------VVK---EKK AqueK183_Aque IQSSHSVTMAMV---T---PLE