CLUSTAL W (1.83) multiple sequence alignment NuaK2_Hsap MLCFTARSGTAVAPRPGAGPVPR---ASA--LPAQPT----D-SPAALAHLLLAMESLVF NuaK1_Hsap MEG------AAAP-VAGDRPDL----GLG--APGSPR----------------------- CG11870_Dmel MVI------SKP---DGTAP--N---GAA-GGAEAAAPTGLDATGNSLA----------- NuaK2_Mmus MES------VALLQRPSQAP--S---ASA--LA--------------------------- NuaK1_Mmus MEG------AAVS-AAGDGPAV----ETG--LPGSPL----------------------- NuaK_Spur MTG------DCPVKAAVEES--D---GNS--LSN-------------------------- unc-82_Cele MTL------SSFLCNAGKLV--KCVRRAISIRDQAAEDQCIDDCNNNHC----------- AqueK066_Aque M----------------------------------------------------------- * NuaK2_Hsap ARRSGPTPSAAELARPLAEGLIKSPKPLMKKQAVKRHHHKHNLRHR------------YE NuaK1_Hsap ---------------EAVAGATAA-LEPRKPHGVKRHHHKHNLKHR------------YE CG11870_Dmel ----------HPSGIPQDQ-IDNIMSGIANTGNVKMNNHRKKLRQRKVAPELIESILKFD NuaK2_Mmus ----------SESARPLADGLIKSPKPLMKKQAVKRHHHKHNLRHR------------YE NuaK1_Mmus ---------------EAVAGATAAPVEPRKPHGVKRHHHKHNLKHR------------YE NuaK_Spur ------------ASAPAGT-AATTPVAAASSAGVKHHRHRHKLKHR------------YR unc-82_Cele ----------VVTHEPTC---SKYIYGTHPMSGAEPCSPTKKEKHR------------FE AqueK066_Aque --------------------------------------------DN------------YR .. : NuaK2_Hsap FLETLGKGTYGKVKKARE-SSGRLVAIKSIRKDKIKDEQDLMHIRREIEIMSSLNHPHII NuaK1_Hsap LQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDEQDMVHIRREIEIMSSLNHPHII CG11870_Dmel IIKKLGQGTYGKVQLGINKETGQEVAIKTIKKCKIEAEADLVRIRREVQIMSSVHHPNII NuaK2_Mmus FLETLGKGTYGKVKKARE-SSGRLVAIKSIRKDKIKDEQDLLHIRREIEIMSSLNHPHII NuaK1_Mmus LQETLGKGTYGKVKRATERFSGRVVAIKSIRKDKIKDELDMVHIRREIEIMSSLNHPHII NuaK_Spur FEKTLGKGTYGKVKLATEISTGNQVAIKSIPKNKIEDPEDMRRIRQEIELMSTLDHPNIV unc-82_Cele ITKKLGSGTYGKVSLAYDHKFDREVAVKLIKKSAIESKADLVRIRREIRIMSALNHPNII AqueK066_Aque ILKKIGSGSFAKVYTALDKTTNEKVALKVINKANISSGKLRERLEREIENMKTLKHKHIV : :.:*.*::.** . : .. **:* * * *. ::.:*:. *.::.* :*: NuaK2_Hsap AIHEVFENSSKIVIVMEYASRGDLYDYISERQQLSEREARHFFRQIVSAVHYCHQNRVVH NuaK1_Hsap SIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVH CG11870_Dmel HIYEVFENREKMVLVMEFAAGGELYDYLSERKVLTEEEARRIFRQVATAVYYCHKHKICH NuaK2_Mmus AIHEVFENSSKIVIVMEYASRGDLYDYISERPRLSERDARHFFRQIVSALHYCHQNGIVH NuaK1_Mmus SIYEVFENKDKIVIIMEYASKGELYDYISERRRLSERETRHFFRQIVSAVHYCHKNGVVH NuaK_Spur NIYEVFESKEKIVIVLEYASGGELYEFIDS-SSIPMGEIQRLFRQIVSALAYCHLNNIVH unc-82_Cele QIYEVFENKDKIILVMEYSSGGELYDYVSRCGSLPEAEARRIFRQITSAVLYCHKHRVAH AqueK066_Aque SYYDSFETEKEMCIAMEYVSGGELFDYIAEKQGLGETEARRLFSQIACAVHHCHLNNISH :: **. .:: : :*: : *:*:::: : : :::* *:. *: :** : : * NuaK2_Hsap RDLKLENILLDANGNIKIADFGLSNLYHQGKFLQTFCGSPLYASPEIVNGKPYTGPEVDS NuaK1_Hsap RDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDS CG11870_Dmel RDLKLENILLDEKGNAKIADFGLSNVFDDQRLLGTFCGSPLYASPEIVEGTPYQGPEVDC NuaK2_Mmus RDLKLENILLDANGNIKIADFGLSNLYHKGKFLQTFCGSPLYASPEIVNGKPYVGPEVDS NuaK1_Mmus RDLKLENILLDDNCNIKIADFGLSNLYQKDKFLQTFCGSPLYASPEIVNGRPYRGPEVDS NuaK_Spur RDLKLENVLLDQDGDAKIADFGLSSYYSDNDLLHTFCGSPLYASPEIVNGQPYHGPEVDC unc-82_Cele RDLKLENILLDQNNNAKIADFGLSNYFADKNLLTTFCGSPLYASPEIINGTPYKGPEVDC AqueK066_Aque RDLKLENILLTESKQAKVIDFGFSKETHPNAMTATYCGSALYASPEMIIGKPYQGPECDV *******:** . : *: ***:*. : *:***.******:: * ** *** * NuaK2_Hsap WSLGVLLYILVHGTMPFDGHDHKILVKQISNGAYREPPKPS-DACGLIRWLLMVNPTRRA NuaK1_Hsap WALGVLLYTLVYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDRRA CG11870_Dmel WSLGVLLYTLVYGSMPFDGSNFKRLVKQISQGDYYEPRKPS-RASTLIRDMLTVCPRKRA NuaK2_Mmus WSLGVLLYILVHGTMPFDGQDHKTLVKQISNGAYREPPKPS-DACGLIRWLLMVNPTRRA NuaK1_Mmus WALGVLLYTLIYGTMPFDGFDHKNLIRQISSGEYREPTQPS-DARGLIRWMLMVNPDRRA NuaK_Spur WSLGVILYAMVYKTMPFGGDDFNHLKKQITEGRYYDPCPGS-VQSQLIRHLLSVDPRYRA unc-82_Cele WSLGILLYTLVYGSMPFDGRDFNRMVRQIKRGAYFEPETPS-TASMLIRNMLRVNPERRA AqueK066_Aque WSLGIILFGMLTACMPFDDSNWGSFITSISRSDYPEPPNTSQNAKHLISRMLDPCAATRA *:**::*: :: ***.. : : .*. . * :* * ** :* . ** NuaK2_Hsap TLEDVASHWWVNWGYATRVGE-----------------------------QEAPHEGGHP NuaK1_Hsap TIEDIANHWWVNWGYKSSVCD-----------------------------CDALHDSESP CG11870_Dmel SIEQICSHWWVNENDNVSCLD-L-A--------ED------------------------- NuaK2_Mmus TLEDVASHWWVNWGYTTGVGE-----------------------------QEALREGGHP NuaK1_Mmus TIEDIANHWWVNWGYKSSVCD-----------------------------CDALPDSESP NuaK_Spur TIYDVAHHPWVFGEEADEMLTNELA--------SS------------------------- unc-82_Cele TIFDIASHWWLNLEENMPVIQ-ELPENQIIDHTPLTEREETMIVQDLADEQDVFMEFGHL AqueK066_Aque TISEVLSHPWLNPAPRKSSLQ--------------------------------------- :: :: * *: NuaK2_Hsap GSDSARASMADWL-RRSSR---------------------------------------PL NuaK1_Hsap ----LLARIIDWH-HRSTG---------------------------------------LQ CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus SGDFGRASMADWL-RRSSR---------------------------------------PL NuaK1_Mmus ----LLARIIDWH-HRSTG---------------------------------------LQ NuaK_Spur ----IRGQSIDSLKDREST---------------------------------------ES unc-82_Cele SSE-TRRKIEDFR-IRRKEAEEFNDNSPVKPPKARKTDELTGKISKEQPEEMKSAEKSLR AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap L--------------------------------E-------------------------- NuaK1_Hsap A--------------------------------D-------------------------- CG11870_Dmel -----------------------------------LANQTPVRLDVL------------- NuaK2_Mmus L--------------------------------E-------------------------- NuaK1_Mmus A--------------------------------E-------------------------- NuaK_Spur S--------------------------------D-TESE--SKPAVV------------- unc-82_Cele GVKEEKEKPKVVDPNDPLERLRQIENRLGQNKKDKEAAKTSARVETVKLKEVKKEKSPEQ AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap ---NGAKVCSFFKQHAPGGGSTT------------------------------------- NuaK1_Hsap ---TEAKMKGLAKP-----TTSE------------------------------------- CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus ---NGAKVCSFFKQHVPGGGSTV------------------------------------- NuaK1_Mmus ---AEAKMKGLAKP-----GASE------------------------------------- NuaK_Spur AVKPTSILKGTSQD-----SDAM------------------------------------- unc-82_Cele QPEDPKTARGTSKP-----ADSRAPSFVPVKDRPETSEPERPRTRPHLTASAYRIETDSL AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap ------------------------------------------------------------ NuaK1_Hsap ------------------------------------------------------------ CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus ------------------------------------------------------------ NuaK1_Mmus ------------------------------------------------------------ NuaK_Spur ------------------------------------------------------------ unc-82_Cele NMLMNQVLEQMEKGPVNLNIIARIKAHPLYDTRPMVKELLESIIAAQPEPVQKQTSKVVE AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap -PGLERQHSLKKSRKEND-MAQSLHSDTADDTA--HRPGKSNLKLPKGILKKKVSASAEG NuaK1_Hsap -VMLERQRSLKKSKKEND-FAQSGQD----AVP--ESPSKLSSKRPKGILKKRSNSEHRS CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus -PGLERQHSLKKSRKEND-MAQNLQGDPAEDTS--SRPGKSSLKLPKGILKKKSSTSSGE NuaK1_Mmus -VVLERQRSLKKSKKEND-FPQSGQD----SVP--ESPSKLSSKRPKGILKKRSNSEHRS NuaK_Spur -VAVEQPHEESTLVQEQPKVSNASK-DSDSDSP--SSP---------------------- unc-82_Cele QQTFSRQNTLTRKKKEDP-LEEE-----IPEVPSPSRK---------------------- AqueK066_Aque --------------------------------------------LPPLARRRQGISHSKS NuaK2_Hsap V--------------------------------------QEDPP-ELSPI---PASP--- NuaK1_Hsap HSTGF-------------------IEGVVGPALPSTFKMEQDLCRTGVLL---PSSPEAE CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus V--------------------------------------QEDPQ-ELRPV---PDTP--- NuaK1_Mmus HSTGF-------------------IEGIVSPALPSPFKMEQDLCRTAIPL---PSSPEAD NuaK_Spur ----VV------------------------------------------------------ unc-82_Cele ----MKERPWHSVEVCMKNESVGFD----PDEEPEHDRMQESIASNATEVTVQDTSFEDD AqueK066_Aque IALE-------------------------------------------------------- NuaK2_Hsap --GQA------AP-LLPKKGILKKPRQRESGYYSS--PEPSESG--------ELLDAGDV NuaK1_Hsap VPGKLSPK--QSA-TMPKKGILKKTQQRESGYYSS--PERSESS--------ELLDSNDV CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus --GQPVP---AVS-LLPRKGILKKSRQRESGYYSS--PEPSESG--------ELLDASDV NuaK1_Mmus MSGKLSLK--QSA-TMPKKGILKKTQQRESGYYSS--PERSESS--------ELLDSNDV NuaK_Spur -------L--QAKGLPQVKGVIQNETDSFLSLASSTATLPSEGSSAIS--NDSVFDSADV unc-82_Cele SSDEEERKKTPVA-STPKTPVLIVEKQESSTNAED--EESDEGDDYSDAEMEELADEVDK AqueK066_Aque ---------------------ITKSIMTEAGLSCT--CDCHSRS--------EMRDSA-I NuaK2_Hsap ----------FVSGDPKEQKPP----QASGLLLHRKGILKLNGKF--S------------ NuaK1_Hsap ----------MGSSIPSPSPPDPARVTSHSLSCRRKGILKHSSKY--S------------ CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus ----------FVSGDPVEQKSP----QASGLLLHRKGILKLNGKF--S------------ NuaK1_Mmus ----------VISGGLSSPPPDPARGTSHSLSCRRKGILKHSSRY--S------------ NuaK_Spur ----------FLPATD-------------------------------------------- unc-82_Cele KGPSDSKLAPVVENLEANPPPDPSS-SPQFLDAFDRGLIKRQSKGKYQAKEILQTYPNNK AqueK066_Aque ----------R----------------LHCESC--------------------------- NuaK2_Hsap ------------------------------------------------------------ NuaK1_Hsap ------------------------------------------------------------ CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus ------------------------------------------------------------ NuaK1_Mmus ------------------------------------------------------------ NuaK_Spur ------------------------------------------------------------ unc-82_Cele LDARGIDVELRRKLRMEKVKADLLKQPKDGDKPRNSYVGSVPPRSPPPIVVKSDGEELDD AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap --------------------------------------QT--------ALELAA------ NuaK1_Hsap --------------------------------------AG--------TMDPAL------ CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus --------------------------------------RT--------ALEGTT------ NuaK1_Mmus --------------------------------------DG--------GTDPAL------ NuaK_Spur ------------------------------------------------------------ unc-82_Cele EEEEEEDEEEIEETDSEEGSDFENFKPKRPIIAAVRRDDGAVVPVIHQTTRPAVVSPNSQ AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap ------P-TTFGSLDELAPPR----PLAR------------------------------- NuaK1_Hsap ------VSPEMPTLESLSEPGVPAEGLSRS------------------------------ CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus ------P-STFGSLDQLASSH----PAAR------------------------------- NuaK1_Mmus ------TRPEMPTLESLSPPGVPSDGISRS------------------------------ NuaK_Spur -------------VVKRRPE---------------------------------------- unc-82_Cele NPRYQVASPKTSTVIQATPEKVPVAGTSAKYLVTVAELKLKPTDKKEEAQLKEQLKDSEI AqueK066_Aque ------------------EPMSPTEGKSRPL----------------------------- NuaK2_Hsap ------------------------------------------------------------ NuaK1_Hsap ------------------------------------------------------------ CG11870_Dmel -------LSLTPATITADQLV--------------------------------------- NuaK2_Mmus ------------------------------------------------------------ NuaK1_Mmus ------------------------------------------------------------ NuaK_Spur -H-VKTVKTQRPATV-------------------------------GALYS--------- unc-82_Cele NSERKVTKGAAPSTISQDSDGKDTFESASAYIRRKNRERRQRNRTIGTAEEALRALERPS AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap ------------------------------------------------------------ NuaK1_Hsap ------------------------------------------------------------ CG11870_Dmel --------------------------VPSAEG--------------AAAAKAAANERVPR NuaK2_Mmus ------------------------------------------------------------ NuaK1_Mmus ------------------------------------------------------------ NuaK_Spur -------------------------DLPSPRTLVNQLIGEDTIFECSEEEK---RASARL unc-82_Cele VDPYDDRAFSPLSTDPFYSHHSSGSAAPSALG--------------YVR--PRYHDDSYR AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap --------------------------------ASRPSGAVSEDSILSSESFDQLDLPERL NuaK1_Hsap --------------------------------YSRPSSVISDDSVLSSDSFDLLDLQENR CG11870_Dmel SHSVG------------SIR-------D-MGP-------------PNTE----------- NuaK2_Mmus --------------------------------PSRPSGAVSEDSILSSESFDQLDLPERL NuaK1_Mmus --------------------------------YSRPSSIISDDSVLSSDSFDLLELQENR NuaK_Spur SKRISCGKYSKITELWESIFNESHHLQAMMSSKSPKSGSGSDESPGSSSSEDLLEILNSK unc-82_Cele THRDS------------DYR-------P-MSPTSRYTAAVTRDDRGKSTSYDPHET---- AqueK066_Aque ---------------------------------DNSSSTMQSTTSLCSSGYS-------- : NuaK2_Hsap PE-PPL-RGCVSVDNL-------------------------------------------- NuaK1_Hsap PARQRI-RSCVSAENF-------------------------------------------- CG11870_Dmel -AERRI------------------------------------------------------ NuaK2_Mmus PE-TPL-RGCVSVDNL-------------------------------------------- NuaK1_Mmus PARQRI-RSCVSAENF-------------------------------------------- NuaK_Spur HLKKSY-----SSSF--------------------------------------------- unc-82_Cele -TRPSYDRGYITSSNASPSYTRKFEHEQPTLNSWANDRKFEVYKTRAERDAERNTYHPTG AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap ---------------------TGLEE---------------------------------- NuaK1_Hsap ---------------------LQIQDF--------------------------------- CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus ---------------------RGLEQ---------------------------------- NuaK1_Mmus ---------------------LQLQDF--------------------------------- NuaK_Spur ------------------------------------------------------------ unc-82_Cele TTGASSYRPSSYYTSASDRPVTGLRRPEESYTSSTNYGRYDGRSTTPSNDQYAISTALAE AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap ------------------------------------------------------------ NuaK1_Hsap ------------------------------------------------------------ CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus ------------------------------------------------------------ NuaK1_Mmus ------------------------------------------------------------ NuaK_Spur ------------------------------------------------------------ unc-82_Cele NQASSMNNRFRPTARRVASAMTDADRRNYHRSRSMDRNKVDYEYGSNLLNRLTTPDSHGD AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap ------------------------------------------------------------ NuaK1_Hsap ------------------------------------------------------------ CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus ------------------------------------------------------------ NuaK1_Mmus ------------------------------------------------------------ NuaK_Spur ------------------------------------------------KLTRHSFSSHRR unc-82_Cele YSYVNYHDSSNGRSNITLEKDGQPRSILKNKQSADIEPRVESSYEPSNGVRSHEFLDQLL AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap ----------------------------------PPSE------GP-------------- NuaK1_Hsap ---------------------------------EGLQN------RP-------------- CG11870_Dmel ------------------------------------------------------------ NuaK2_Mmus ----------------------------------PPSE------G--------------- NuaK1_Mmus ---------------------------------ETPHN------RP-------------- NuaK_Spur SMR--------------------THKEMVIMEAHQLQM------RS-------------- unc-82_Cele SMRFILQVFERLRRHLSLEKSVSPQRQVASVGPHSRNIDSTSSALDNPKKKRSLLSFNRR AqueK066_Aque ------------------------------------------------------------ NuaK2_Hsap ---------------------G---SCLRR---------WRQDPLGDSCFS-LT-DCQEV NuaK1_Hsap ---------------------RP--QYLKR----------YRNRLADSSFSLLT-DMDDV CG11870_Dmel ---------------------------------------------LDMV--AGE------ NuaK2_Mmus ---------------------------LKR---------WWQESLGDSCFS-LT-DCQEV NuaK1_Mmus ---------------------RP--Q--------------YLKRLADSSFSLLT-DMDDV NuaK_Spur ---------------------ES--LFEKP---------EFRKGTRDSG--LGD-DLENL unc-82_Cele KTSEVRMGADGKLVTNGYDSTPSSRDFKRPSSPIDRIKSLFRKN-ESSG--TGHSDYYNS AqueK066_Aque ----------------------------------------------SSTESLVT-SPPAL . NuaK2_Hsap TA-----------------TYRQAL---------------------------RVCSKLT NuaK1_Hsap TQ-----------------VYKQAL---------------------------EICSKLN CG11870_Dmel --S-----------------MSILL---------------------------LDASEIA NuaK2_Mmus TA-----------------AYRQAL---------------------------GICSKLS NuaK1_Mmus TQ-----------------VYKKAL---------------------------EICSKLN NuaK_Spur AK-----------------VYQKAL---------------------------EISSSVN unc-82_Cele SRNYTSSNPVSTTREPYVAQYRKYPGSTSRDTSSALNRYSYTPGLTDQRRHWYDDPNIY AqueK066_Aque TQS----------------SYTKPVPANSE----------------------LVDIVFV .