CLUSTAL W (1.83) multiple sequence alignment PCTAIRE3_Hsap MI---------------------------------------------------------- PCTAIRE2_Hsap ------------------------------------------------------------ PCTAIRE1_Hsap MP--------LYGRARDHVTHPSILGTRPG-RPMAGPITAAVPEKICNGAFCSCSGAFPL PCTAIRE3_Mmus M----------------------------------------------------------- PCTAIRE2_Mmus ------------------------------------------------------------ PCTAIRE1_Mmus MWGWCQRNMPFYGHTQDLVTSSSAL-TEPLVPTVAAAVTAATPEDSCCGVLCSHSETITL ZC123.4_Cele MD---------------------------------------------------------- Pctaire_Spur M----------------------------------------------------------- AqueK103_Aque ------------------------------------------------------------ PCTAIRE3_Hsap -----------------------MNKMKNFKRRFSLSVPRTET-I--------------- PCTAIRE2_Hsap --------------------------MKKFKRRLSLTLRGSQT-I--------------- PCTAIRE1_Hsap DPNNPSLGPLPSISHLNLRTQIAMDRMKKIKRQLSMTLRGGRG-I--------------- PCTAIRE3_Mmus ------------------------NKMKNFKRRLSLSVPRPET-I--------------- PCTAIRE2_Mmus --------------------------MKKFKRRLSLTLRGSQT-I--------------- PCTAIRE1_Mmus ETNNLMSGPLPSASHSSLSTQVAMDRMKKIKRQLSMTLRGGRG-I--------------- ZC123.4_Cele --------------------------LKSTKKTWKI--PSFNQMWGKITSHIGVWFGLEE Pctaire_Spur ------------------------------------------------------------ AqueK103_Aque --------------------------MSAVKKRLSLTFGRTKS-R--------------- PCTAIRE3_Hsap -------EESLAE--FTEQF--------------------------NQLHNRRNENLQLG PCTAIRE2_Hsap -------DESLSE--LAEQM--------------------------TIEENSSKDNEPIV PCTAIRE1_Hsap -------DKTN-G--APEQI--------------------------GLDESGGGGGSDP- PCTAIRE3_Mmus -------EESLAE--FTEQF--------------------------NQLHTQTNE----- PCTAIRE2_Mmus -------DESLSE--LAEQM--------------------------TIEESSSKDNEPIV PCTAIRE1_Mmus -------DKTN-G--VPEQI--------------------------GLDESGGGGGSDL- ZC123.4_Cele AERPMRASCSLSMIHHPQLTAVRSSKSSENLH------------RITTMSPQRIQDVDGS Pctaire_Spur ----------VEE--IPEIN--------------------------KIE----------- AqueK103_Aque -------DHSYTG--IVDEG-----KTASNCLFVTTGIIAGAQDGFTKVEDEGAEVDAYP : PCTAIRE3_Hsap PLGRDPPQECSTF----------------------------------------------- PCTAIRE2_Hsap KNGRPPTS-HSMHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLK PCTAIRE1_Hsap --G-------------------------EAPTRAAPGELRSARG--PLSSAPEIVHEDLK PCTAIRE3_Mmus ------------------------------------------------------------ PCTAIRE2_Mmus KNGRPPTS-HSVHSFLHQYTGSFKKPPLRRPHSVIGGSLGSFMAMPRNGSRLDIVHENLK PCTAIRE1_Mmus --G-------------------------EAPTRIAPGELRSVRG--PLSSAPEIVHEDMK ZC123.4_Cele PSTRKPSS--SIFT----LRRSRNKE-KKYKNNGGGGSTKSPISKNGTNEMTQSWHSN-- Pctaire_Spur ------------------------------------------------------------ AqueK103_Aque TDGPLPAA--TLRSKTTRYS------------------------------RADNEHKRFT PCTAIRE3_Hsap ------SPT-DSGEEPGQLSPGVQ-FQR-------RQNQRRFSMEVRASGALPRQVAGCT PCTAIRE2_Hsap MGSDGESDQASGTSSDEVQSPTGV-CLR-------NRIHRRISM---------------- PCTAIRE1_Hsap MGSDGESDQASATSSDEVQSPVRV-RMR-------NHPPRKIST---------------- PCTAIRE3_Mmus ----------DGTDEPEQLSPGMQ-YQQ-------RQNQRRFSM---------------- PCTAIRE2_Mmus MGSDGESDQASGTSSDEVQSPTGV-CLR-------NRIHRRISM---------------- PCTAIRE1_Mmus MGSDGESDQASATSSDEVQSPVRV-RMR-------NHPPRKIST---------------- ZC123.4_Cele -HVNGASSGSGSGSTPEHHNKNIFSFLSRQSRSRSNNPSETMST---------------- Pctaire_Spur -------------------SP---------------------GD---------------- AqueK103_Aque LPLFGGSLGRSASSSNVDMSTI--------------SPERSLATS-------SKA-K--- . . PCTAIRE3_Hsap HKGVHRRAAALQPDFDVSKRLSLPMDIRLPQEFLQKLQMESPDLPKPLS----------- PCTAIRE2_Hsap --------------EDLNKRLSLPADIRIPDGYLEKLQINSPPFDQPMS----------- PCTAIRE1_Hsap --------------EDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLS----------- PCTAIRE3_Mmus --------------EDLNKRLSLPMDIRLPQEFLQKLQLENPGLPKPLT----------- PCTAIRE2_Mmus --------------EDLNKRLSLPADIRIPDGYLEKLQISSPPFDQPMS----------- PCTAIRE1_Mmus --------------EDINKRLSLPADIRLPEGYLEKLTLNSPIFDKPLS----------- ZC123.4_Cele --------------VPL--------------------NKNSPSMPPPPSSNTVADFTHLR Pctaire_Spur --------------RDISKRLSLPVDMRLPEQFIEKYSLS-PPFEK-MS----------- AqueK103_Aque ---------AK-SSFDL--------TVSPPV----SPTDGKPIFMPFAN----------- : * : . PCTAIRE3_Hsap -RMSRRASL----------SDIGF-GKLETYVKLDKLGEGTYATVFKGRSKLTENLVALK PCTAIRE2_Hsap -RRSRRASL----------SEIGF-GKMETYIKLEKLGEGTYATVYKGRSKLTENLVALK PCTAIRE1_Hsap -RRLRRVSL----------SEIGF-GKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALK PCTAIRE3_Mmus -RMSRRASL----------SDIGF-GKLETYVKLDKLGEGTYATVFKGRSKLTENLVALK PCTAIRE2_Mmus -RRSRRASL----------SEIGF-GKMETYIKLEKLGEGTYATVYKGRSKLTENLVALK PCTAIRE1_Mmus -RRLRRVSL----------SEIGF-GKLETYIKLDKLGEGTYATVYKGKSKLTDNLVALK ZC123.4_Cele RRRPRSAHYDPNTITLPAKEEVTPQDVNDLYKRIDKLGEGSYATVYKCESKLDGSIVALK Pctaire_Spur -RRSRRASL----------SEIGF-GKMETYTKLDKLGEGTYATVFKGRSRLTDNLVALK AqueK103_Aque -RMQRRASL----------SEIGF-GKLQTYEKLEKLGEGTYATVYKGKSNITGKLVALK * * . .:: . : * :::*****:****:* .*.: .:**** PCTAIRE3_Hsap EIRLEHEEGAPCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHC PCTAIRE2_Hsap EIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDC PCTAIRE1_Hsap EIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC PCTAIRE3_Mmus EIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHC PCTAIRE2_Mmus EIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIVHTDKSLTLVFEYLDKDLKQYMDDC PCTAIRE1_Mmus EIRLEHEEGAPCTAIREVSLLKDLKHANIVTLHDIIHTEKSLTLVFEYLDKDLKQYLDDC ZC123.4_Cele EIKLQFQEGLPFTAIREASLLRNLRHANIVSLHDIFYQHHQLTFVFEYMKMDLSKYLEQN Pctaire_Spur EIRLEHEEGAPCTAIREVSLLKGLKHHNIVTLHDIVHTEKALTLVFEYLEKDLKQYMDDC AqueK103_Aque EIRLEHEEGAPCTAIREVSLLKDLKHANIVFLHDIIHTARSLTLIFEYVEQDLKQYLDQC **:*:.:** * *****.***:.*:* *** ***:.: : **::***:. **.:*::. PCTAIRE3_Hsap GNLMSMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVP PCTAIRE2_Hsap GNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINEKGELKLADFGLARAKSVP PCTAIRE1_Hsap GNIINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIP PCTAIRE3_Mmus GNLMNMHNVKIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVP PCTAIRE2_Mmus GNIMSMHNVKLFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVP PCTAIRE1_Mmus GNVINMHNVKLFLFQLLRGLAYCHRQKVLHRDLKPQNLLINERGELKLADFGLARAKSIP ZC123.4_Cele VYGLDSIDIKLLLFQLLRGLDFCHRKKILHRDLKPQNLLLDEDGVLKLADFGLARAKSVP Pctaire_Spur GSIMNMNNVKLFLFQLLRGLAYCHKRQVLHRDLKPQNLLINEKGELKLADFA-------- AqueK103_Aque SGMMAMPNVKLFLFQLMRGLQYCHSRKILHRDLKPQNLLISEQGDLKLADFGLARAKSVP : ::*::::*::*** :** :::***********:.* * ******. PCTAIRE3_Hsap TKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGST------VK PCTAIRE2_Hsap TKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGST------VE PCTAIRE1_Hsap TKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGST------VE PCTAIRE3_Mmus TKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGKPLFPGST------VK PCTAIRE2_Mmus TKTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGST------VE PCTAIRE1_Mmus TKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMATGRPLFPGST------VE ZC123.4_Cele SRTYSHEVVTLWYRPPDVLMGSTDYSTSLDMWGVGCIFAEICTGAALFPGSKDSHYPGTK Pctaire_Spur -NVFSPHLVSSLERSRNAVLPNTIFL--FCTRGVGCIFYEMSAGRPLFPGST------VE AqueK103_Aque TKTYSNEVVTLWYRPPDVLLGSIDYADSIDMWGVGCIFYEMIVGRPMFPGAN------VE ..:* .:*: *. : :: . : : ***** *: * .:***:. .: PCTAIRE3_Hsap EELHLIFRLLGTPTEETWPGVTAFSEFRTYSFPCYLPQPLINHAPR---LDTDGIHLLSS PCTAIRE2_Hsap DELHLIFRLLGTPSQETWPGISSNEEFKNYNFPKYKPQPLINHAPR---LDSEGIELITK PCTAIRE1_Hsap EQLHFIFRILGTPTEETWPGILSNEEFKTYNYPKYRAEALLSHAPR---LDSDGADLLTK PCTAIRE3_Mmus EELHLIFRLLGTPTEESWPGVTSISEFRAYNFPRYLPQPLLSHAPR---LDTEGINLLSS PCTAIRE2_Mmus DELHLIFRLLGTPSQETWPGVSSNDEFKNYNFPKYKPQPLINHAPR---LDSEGIELITK PCTAIRE1_Mmus EQLHFIFRILGTPTEETWPGILSNEEFRTYNYPKYRAEALLSHAPR---LDSDGADLLTK ZC123.4_Cele DQLDMIFSIRGTPDEKKWPEVKTLPGYTPELFPRYRELSFIAVNPMFTKILKTGQELLGM Pctaire_Spur DELHLIFKFLGTPDDKTWPGISANEDFVSYGFPGYPKEPVVTHAPR---LDLQCQDLLED AqueK103_Aque EELVLIWKSLGTPNEKTWPGITKNKEFISHSFLRYDPQPLGLIVPR---LDKEGINLMSK ::* :*: *** ::.** : : : * .. * : .*: PCTAIRE3_Hsap LLLYESKSRMSAEAALSHSYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAF-QQP PCTAIRE2_Hsap FLQYESKKRVSAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSY-PET PCTAIRE1_Hsap LLQFEGRNRISAEDAMKHPFFLSLGERIHKLPDTTSIFALKEIQLQKEASLRSSSM-PDS PCTAIRE3_Mmus LLLYESKSRMSAEAALNHPYFQSLGDRVHQLHDTASIFSLKEIQLQKDPGYRGLAF-QHP PCTAIRE2_Mmus FLQYESKKRVPAEEAMKHVYFRSLGPRIHALPESVSIFSLKEIQLQKDPGFRNSSY-PET PCTAIRE1_Mmus LLQFEGRNRISAEDARKHPFFLSLGERIHKLPDTTSIFALKEVQLQKEANIRSTSM-PDS ZC123.4_Cele LLQLRPESRVSAASAMLHPYFASFPREVHLLAPSQSIFRLKELKDLR------------- Pctaire_Spur LLKYEGKNRVSAAKAMRHPCFNCFGSKIHTLRDVQSIMDLPECQLSRDPGIRSSAV-PST AqueK103_Aque LLSYESQERLLARDGMKHNYFSSLPPQIHDLPHIVSIFTIPGVELVKNPGDRKSQKDTKT :* . ..*: * . * * .: .:* * **: : : : PCTAIRE3_Hsap GR---------------------------------------------------------- PCTAIRE2_Hsap GH---------------------------------------------------------- PCTAIRE1_Hsap GR---------------------------------------------------------- PCTAIRE3_Mmus GR---------------------------------------------------------- PCTAIRE2_Mmus GH---------------------------------------------------------- PCTAIRE1_Mmus GR---------------------------------------------------------- ZC123.4_Cele ------------------------------------------------------------ Pctaire_Spur APIHTVIPNPLLAPIHTVRSNPLLAPIHTVIPNPLLAPIHTVIPNPLLAPIHTAPLVGDA AqueK103_Aque SY---------------------------------------------------------- PCTAIRE3_Hsap -------------------GKNRRQ-SIF PCTAIRE2_Hsap -------------------GKNRRQSMLF PCTAIRE1_Hsap -------------------PAFRVVDTEF PCTAIRE3_Mmus -------------------GKSRRQ-SIF PCTAIRE2_Mmus -------------------GKNRRQSMLF PCTAIRE1_Mmus -------------------PAFRVVDTEF ZC123.4_Cele ---------------------------SL Pctaire_Spur RACTFNVTTDFKINDCDEASKFAVTDFIM AqueK103_Aque -------------------DRDRRRSSLY