CLUSTAL W (1.83) multiple sequence alignment PFTAIRE2_Hsap MGQELCAK-------------------TV--QPGC---SCYHCSEG-------------- PFTAIRE1_Hsap MCDLIEPQ-------------------P-------------------------------- Eip63E_Dmel MAELISQP-------------------TK--I-NN--N-NF---------GAGVT---MR PFTAIRE2_Mmus MGQELCAK-------------------RL--QPGC---SCYHRSEG-------------- PFTAIRE1_Mmus MCDLIEPQ-------------------P-------------------------------- pct-1_Cele MKKLKR-----------------RLSAAF--RPGSNN-NVSITSSGGSY----------Y Pftaire_Spur MPILVPTI-------------------LT--M---------------------------- AqueK104_Aque MAATDSVFVDNVFYDYHSQQIKQHMDLVVEGGPGVEENSYRKRSSGGVNGGLEVFIEEKQ * PFTAIRE2_Hsap -----GE-------AHSC------RRSQPET-TEAA-FKLTDL--KEASC---------- PFTAIRE1_Hsap AEK-IGK-------MKKL------RRTLSESFSRIA-LKKDDT--TFDEI---------- Eip63E_Dmel EKK-GGA-------LQKL------KKRLSHSFGRLT-ISREDG--DESTHH--------- PFTAIRE2_Mmus -----GE-------AHSC------QRSQPGS-TEPAVFE---L--TEASS---------- PFTAIRE1_Mmus AEK-IGK-------MKKL------RRTLSESFSRIA-LKKEDT--TFDEI---------- pct-1_Cele DSDCEGRNNIVIGYGMMSAPLHGRTWTLSESMSHLS-DK-NGA--ILEECAVVDPTALLR Pftaire_Spur ------------------------------------------------------------ AqueK104_Aque EEE-EGD-------GEES------RSSVST--TQTS-LKVNGYQARGNSL---------- PFTAIRE2_Hsap ---------------------------SMTSFHPRGLQA--------------------- PFTAIRE1_Hsap ---------------------------CVTKMSTRNCQGM---------------DS--- Eip63E_Dmel ---------------------------HHHHHHHRGGHGGHHNHGNKVPYNGYNSEE--- PFTAIRE2_Mmus ---------------------------STASFHPRGLEA--------------------- PFTAIRE1_Mmus ---------------------------CVTKMSTRNCQGT---------------DS--- pct-1_Cele VSRGGTAGRRYDTNVNYINGMHVPPPRTHSLYYPRGYNSR---------------RNSYY Pftaire_Spur ------------------------------------------------------------ AqueK104_Aque ---------------------------SPMKRHSGGEQEL---------------YA--- PFTAIRE2_Hsap ------------------------------------ARAQ-KFK-------------S-- PFTAIRE1_Hsap ---------------------------VIKPLDT-IPEDK-KVR-------------V-- Eip63E_Dmel --------------Y----------LDRLEPNGN-IPADKTNCRYGDWRSTDSTDHHDRV PFTAIRE2_Mmus ------------------------------------ASAQ-KLK-------------S-- PFTAIRE1_Mmus ---------------------------VIKHLDT-IPEDK-KVR-------------V-- pct-1_Cele GSNASVVQESMILGSDGESVEVSPCTSDQTPTGVPPRYIV-NVK-------------M-- Pftaire_Spur ------------------------------------P--KSSTR------------RARF AqueK104_Aque -------------AQ----------NGEIKPTPS-PRHEP-KQK-------------SR- . : PFTAIRE2_Hsap KRPRS--NSDCFQEEDL------------------------------------------- PFTAIRE1_Hsap QRTQS--TFDPFEK---------------------------PANQVKRVHSENNACINFK Eip63E_Dmel QRQLSVSSDSKLLDEDIREE-MK---YHSHVVMRPKK-PPRPKSEV-------------- PFTAIRE2_Mmus KRPRS--NSDSFQEENL------------------------------------------- PFTAIRE1_Mmus QRTQS--TFDPFEK---------------------------PANQVKRVHSENNACINFK pct-1_Cele RQK--TARKWSEEEIQKRL-SLPADLR-------------LPVA-----------VVDKL Pftaire_Spur I--------------------------------KP-------LPVM-------------- AqueK104_Aque SRPVS--LSISGKPPGLRRNSIPITASSSNDAIGPKPDIVRPIPAFRSTGSISNAVLINH PFTAIRE2_Hsap ----------------------RQG---FQW-RKSLPFGAASSYLNLEKLGEGSYATVYK PFTAIRE1_Hsap TSSTGK----------ESPKVRRHS---SPSSPTSPKFGKADSYEKLEKLGEGSYATVYK Eip63E_Dmel --FLNK----------QETHPRRKR---FSAFGGDSPFGKQEAYVKLEPLGEGSYATVYK PFTAIRE2_Mmus ----------------------RQG---LPW-KKSLPFGAASSYLNLEKLGEGSYAKVYK PFTAIRE1_Mmus SSSAGK----------ESPKVRRHS---SPSSPTSPKFGKADSYEKLEKLGEGSYATVYK pct-1_Cele NR--TP--------TLDQPLT-RKN---RRASLSEIGFGKLETYEKLDKLGEGTYATVFR Pftaire_Spur --VTGP----------TCNHKRFGK---SPYCKSCSPFGKVETYKKICPLGEGSYAKVYK AqueK104_Aque TSTTGSVAGGGTGNSLLLPNQRRFSTSNAPLSPLGSPFGRLETYKKLEALGEGSYATVYK ** .:* :: ****:**.*:: PFTAIRE2_Hsap GISRINGQLVALKVISMNAEEGVPFTAIRE-----ASLLKGLKHANIVLLHDIIHTKETL PFTAIRE1_Hsap GKSKVNGKLVALKVIRLQEEEGTPFTAIRE-----ASLLKGLKHANIVLLHDIIHTKETL Eip63E_Dmel GFSKLTYQRVALKEIRLQEEEGAPFTAIRE-----ASLLKELKHSNIVTLHDIVHTRETL PFTAIRE2_Mmus GISRINGQLVALKVISMNAEEGVPFTAIRE-----ASLLKGLKHANIVLLHDIVHTKETL PFTAIRE1_Mmus GKSKVNGKLVALKVIRLQEEEGTPFTAIRE-----ASLLKGLKHANIVLLHDIIHTKETL pct-1_Cele GRSILTNKFVALKEIRLEQEEGAPCTAIRE-----VSLLRNLRHANVVTLHDIIHTDRLL Pftaire_Spur AVSCINQQVVALKEIRLQQDEGTPFTAIRE-----ASLLKDLKHANIVCLHDIIHTKTTL AqueK104_Aque GISIANGHYVALKEIRLNSEEGTPFTAIREGIMTFASLLKGLKHANIVILHDIIHTSNNL . * . : **** * :: :**.* ***** .***: *:*:*:* ****:** * PFTAIRE2_Hsap TFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQHVLHRDLKPQNLLISH PFTAIRE1_Hsap TLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISD Eip63E_Dmel TFVFEYVNTDLSQYMEKHPGGLDHRNVRLFLFQLLRGLSYCHKRRVLHRDVKPQNLLISD PFTAIRE2_Mmus TFVFEYMHTDLAQYMSQHPGGLHPHNVRLFMFQLLRGLAYIHHQRVLHRDLKPQNLLLSH PFTAIRE1_Mmus TLVFEYVHTDLCQYMDKHPGGLHPDNVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISD pct-1_Cele TLVFEYVDRDLKQYMDSCNNAMQMNNIRLFLYQLLRGLAYCHQRRVLHRDLKPQNLLITA Pftaire_Spur SFVFEYVHTDLSTYLERHPGGLNPNNVRLFLFQLIRGLSFCHKRKILHRDLKPQNLLISE AqueK104_Aque TFVFEYVDTDLSRYMEKHPGPLDPRNVKILLIQLLRGLNFCHRRKILHRDLKPQNILLNH ::****:. ** *:. . :. *::::: **:*** : *:: :****:****:*:. PFTAIRE2_Hsap LGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMF PFTAIRE1_Hsap TGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMI Eip63E_Dmel CGELKLADFGLARAKSVPSHTYSHEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFVEMV PFTAIRE2_Mmus LGELKLADFGLARAKSIPSQTYSSEVVTLWYRPPDALLGATEYSSELDIWGAGCIFIEMF PFTAIRE1_Mmus TGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMI pct-1_Cele KGELKLADFGLARAKSVPTKTYSNEVVTLWYRPPDVLLGSTDYSTHIDMWGVGCILFEMI Pftaire_Spur AGELKLADFGLARAKSIPSRTYSHEVVTLWYRPPDVLMGSTDYSTQLDIWGVGCIFLEMM AqueK104_Aque NGELKLADFGLARAKSVPTKTYSHEVVTLWYRPPDVLMGSTDYFTSLDMWGVGCIFVEML ***************:*::*** ***********.*:*:*:* : :*:**.***:.**. PFTAIRE2_Hsap QGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEW--FPLPTPRSLHVVWN PFTAIRE1_Hsap QGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPER--FTLYSSKNLRQAWN Eip63E_Dmel TGMPTFPGIRDTYDQLDKIFKLLGTPTEDTWPGVTHFPGYKPHK--LGFYRPRKLGHNFP PFTAIRE2_Mmus QGQPLFPGVSNILEQLEKIWEVLGVPTEDTWPGVSKLPNYNPEW--FPPPKPQSLQIVWD PFTAIRE1_Mmus QGVAAFPGMKDIQDQLERIFLVLGTPNEDTWPGVHSLPHFKPER--FTVYSSKSLRQAWN pct-1_Cele AGRALFPGGTP-TEQLGLIFRTLGSPRPDRHPTICEKPTFYPYA--NRHYNPDPLCRQIP Pftaire_Spur WGQPAFPGLKDATDQLEKIFKVLGTPTEQTWHGVSRLPNYGKVAAAGRFHKPKLLCEILP AqueK104_Aque TGKPLFPGLKGVYDQLNRIWSILGTPNNTTWPGVTDLPEYRPEQ--YEQCPPLGLEVVAP * . *** :** *: ** * : * : . * PFTAIRE2_Hsap RLGRVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSALPSQLYQLPDEESLFTVSGVRLK PFTAIRE1_Hsap KLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQ Eip63E_Dmel RLYDIIEGETIANGFLQLNPEQRLGADDALQHPYFAQLPKKLYELPDGENLNFHRGRRAA PFTAIRE2_Mmus RLGGVPEAEDLASQMLKGFPRDRVSAQEALVHDYFSVLPSQLYQLPDEESLFAVSGVKLK PFTAIRE1_Mmus KLSYVNHAEDLASKLLQCSPKNRLSAQAALSHEYFSDLPPRLWELTDMSSIFTVPNVRLQ pct-1_Cele RID--AHGFELLMKFLQYEGKDRVSAAEAVKHPFLRTIAVKCCHLRDEQSVLEADGIHIE Pftaire_Spur SILLIPGAESLMTDMLQLEPRKRISTVQAMTCQYFKDLPPKIFDLPPGASVFNVPGMKLE AqueK104_Aque ILHPKTKVGDLAMKLLQLIPSNRITADDALAHEYFSSLPPAIFALPESASVFLIPGVLFN : : :*: .*: : *: :: :. * .: . PFTAIRE2_Hsap PEMCDLLASYQKGHHP----------AQFSKCW PFTAIRE1_Hsap PEAGESMRAFGKNNSYGK--------SLSNSKH Eip63E_Dmel LHG-------------------------AKSTE PFTAIRE2_Mmus PEMCDLSASYRKRHHL----------VGVNKCW PFTAIRE1_Mmus PEAGESMRAFGKNNSYGK--------SLSNSKH pct-1_Cele RELLASDHHHSSRRHHRGTLVKDKYRMHSSHHT Pftaire_Spur PEK-------------------------NNLSK AqueK104_Aque --------------------------------R