CLUSTAL W (1.83) multiple sequence alignment PKCg_Hsap MAGLGP----------------------GVGDSEG------------------------- PKCb_Hsap MADPAA----------------------GPPPSEG------------------------- PKCa_Hsap MADVFP----------------------GNDSTAS------------------------- Pkc53E_Dmel MSEGSD----------------------NNGDPQQQGAE-----G--------------- inaC_Dmel MAAAAVATPGATVLPPSVPSAAPGAKAPAAGAGKG-PGNLLEITG--------------- PKCg_Mmus MAGLGP----------------------GGGDSEG------------------------- PKCb_Mmus MADPAA----------------------GPPPSEG------------------------- PKCa_Mmus MADVYP----------------------ANDSTAS------------------------- pkc-2_Cele MEVPQAQSLAAAALI-----------SPVKNNSTGGGGN-----QQLCIRKSISNPSSLK PKCa_Spur MSDSS------------------------------------------------------- AqueK016_Aque MAEGSP------------------------------------------------------ * PKCg_Hsap ---------------------------------------GP-RPLFCRKGALRQKVVHEV PKCb_Hsap ---------------------------------------EESTVRFARKGALRQKNVHEV PKCa_Hsap ---------------------------------------QDVANRFARKGALRQKNVHEV Pkc53E_Dmel -----------------------------------EAVGENKMKSRLRKGALKKKNVFNV inaC_Dmel -----------------------------------EANIVNYMKNRLRKGAMKRKGLEMV PKCg_Mmus ---------------------------------------GP-RPLFCRKGALRQKVVHEV PKCb_Mmus ---------------------------------------EESTVRFARKGALRQKNVHEV PKCa_Mmus ---------------------------------------QDVANRFARKGALRQKNVHEV pkc-2_Cele VYAHHEAPGIIHFPRFEFSHRLSIRPLLKRLHEQAQ---RIEGKAFVRRGALRQKNVHEI PKCa_Spur ----------------------------------------FEMKGFARRGALRQKNVYEI AqueK016_Aque ------------------------------------------VRRPKRRNAVKQGKVVEI *:.*::: : : PKCg_Hsap KSHKFTARFFKQPTFCSHCTDFIWGI-GKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGP PKCb_Hsap KNHKFTARFFKQPTFCSHCTDFIWGF-GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGP PKCa_Hsap KDHKFIARFFKQPTFCSHCTDFIWGF-GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGP Pkc53E_Dmel KDHCFIARFFKQPTFCSHCKDFIWGF-GKQGFQCQVCSYVVHKRCHEYVTFICPGKDKGI inaC_Dmel NGHRFGVRFFKNPTYCGHCKDFIWGF-GKQGFQCEECRFNIHQKCCKFVVFKCPGKDTDF PKCg_Mmus KSHKFTARFFKQPTFCSHCTDFIWGI-GKQGLQCQVCSFVVHRRCHEFVTFECPGAGKGP PKCb_Mmus KNHKFTARFFKQPTFCSHCTDFIWGF-GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGP PKCa_Mmus KDHKFIARFFKQPTFCSHCTDFIWGF-GKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGP pkc-2_Cele KSHKFIARFFKQPTFCSHCKDFLWGI-TKQGFQCQVCTLVVHKRCHEFVNFACPGADKGV PKCa_Spur KNHKFIPRFFKQPTFCSHCKDFIWGF-GKQGFQCTVCSFVVHKRCHEFVTFMCPGIDHGA AqueK016_Aque KGHKFVLTYFKQFTFCGHCTRFLWGLTGPQGYRCLSCDFTIHRRCLEYVSFICPGTSL-P :.* * :**: *:*.**. *:**: ** :* * :*::* ::* * *** . PKCg_Hsap QTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGV PKCb_Hsap ASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGT PKCa_Hsap DTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGM Pkc53E_Dmel DSDSPKTQHNFEPFTYAGPTFCDHCGSLLYGIYHQGLKCSACDMNVHARCKENVPSLCGC inaC_Dmel DADCAKVKHGWISTTYTTPTFCDECGLLLHGVAHQGVKCENCNLNVHHACQETVPPMCGA PKCg_Mmus QTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMNVHRRCVRSVPSLCGV PKCb_Mmus ASDDPRSKHKFKIHTYSSPTFCDHCGSLLYGLIHQGMKCDTCMMNVHKRCVMNVPSLCGT PKCa_Mmus DTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGM pkc-2_Cele DTDDPRQQHKWKVQTYSSPTFCDHCGSLLYGILHQGMKCQSCDTNVHHRCVKNVPNMCGT PKCa_Spur DTDDPRNKHKFEVNSYNSPTFCDHCGSLLYGLYHQGMRCGACNMNVHKRCQKSVPNLCGA AqueK016_Aque AGLEPR-PHTFKTASFYHPTFCAHCGSMIYGLFNQGVRCSDCGMTAHHRCQALVPRACGQ .: * : :: **** .** :::*: :**::* * ..* * ** ** PKCg_Hsap DHTERRGRLQLEIRA---PTA-DEIHVTVGEARNLIPMDPNGLSDPYVKLKLIPDP-RN- PKCb_Hsap DHTERRGRIYIQAHI----DR-DVLIVLVRDAKNLVPMDPNGLSDPYVKLKLIPDP-KS- PKCa_Hsap DHTEKRGRIYLKAEV----AD-EKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDP-KN- Pkc53E_Dmel DHTERRGRIYLEINV----KE-NLLTVQIKEGRNLIPMDPNGLSDPYVKVKLIPDD-KD- inaC_Dmel DISEVRGKLLLYVEL----KG-NNLKVDIKEAANLIPMDTNGFSDPYIAVQMHPDR-SG- PKCg_Mmus DHTERRGRLQLEIRA---PTS-DEIHITVGEARNLIPMDPNGLSDPYVKLKLIPDP-RN- PKCb_Mmus DHTERRGRIYIQAHI----DR-EVLIVVVRDAKNLVPMDPNGLSDPYVKLKLIPDP-KS- PKCa_Mmus DHTEKRGRIYLKAEV----TD-EKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDP-KN- pkc-2_Cele DNTEKRGRLRIEAHI----EN-DQLTIKILEAKNLIPMDPNGLSDPYVKCKLIPEDSGC- PKCa_Spur DHTERRGRIRLKAEV----TE-NKLKVTVEEAKNLIPMDPNGLSDPFVKLKLIPDQ-KN- AqueK016_Aque DTQEKRGRIKVGFYTQRSTENNWRINIEIIECRNLPPMDPNGLADPFVKVSLLDSDGKDK * * **:: : : : : : ** ***.**::**:: .: . PKCg_Hsap -LTKQKTRTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSE PKCb_Hsap -ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISE PKCa_Hsap -ESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSE Pkc53E_Dmel -QSKKKTRTIKACLNPVWNETLTYDLKPEDKDRRILIEVWDWDRTSRNDFMGALSFGISE inaC_Dmel -RTKKKTKTIQKNLNPVFNETFTFELQPQDRDKRLLIEVWDWDRTSRNDFMGSFSFSLEE PKCg_Mmus -LTKQKTKTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSE PKCb_Mmus -ESKQKTKTIKCSLNPEWNETFRFQLKESDKDRRLSVEIWDWDLTSRNDFMGSLSFGISE PKCa_Mmus -ESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSE pkc-2_Cele -KSKQKTKTLRATLNPQWNETFTYKLLPGDKDRRLSIEVWDWDRTSRNDFMGSLSFGISE PKCa_Spur -QTKKKTKTIKGNLNPTWGESFEFTMEESDRNRRLLVGVWDWDRATRNDFMGALSFGISX AqueK016_Aque SSMKQKTERREKTLDPKFDESFFFDVSEQDLNNFVYVAVWDWDRIGSNDFIGGMGLKVND *:**. . *:* :.*:: : : * :. : : :**** ***:*.:.: :. PKCg_Hsap LLKAPV-----DGWYKLLNQEEGEYYNVPVADAD---NCSLLQKFEACNYPLELYERVRM PKCb_Hsap LQKASV-----DGWFKLLSQEEGEYFNVPVPPEGSEANEELRQKFER----------AKI PKCa_Hsap LMKMPA-----SGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEK----------AKL Pkc53E_Dmel IIKNPT-----NGWFKLLTQDEGEYYNVPCADD-EQDLLKLKQKPSQ------------- inaC_Dmel LQKEPV-----DGWYKFLSQVEGEHYNIPCVDAF-NDIARLRDEVRH----------DR- PKCg_Mmus LLKAPV-----DGWYKLLNQEEGEYYNVPVADAD---NCSLLQKFEACNYPLELYERVRM PKCb_Mmus LQKAGV-----DGWFKLLSQEEGEYFNVPVPPEGSEGNEELRQKFER----------AKI PKCa_Mmus LMKMPA-----SGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEK----------AKL pkc-2_Cele LMKEAA-----SGWYKLLSAEEGEFYNINITPEYDEDMEKVRKKMNE----------NFI PKCa_Spur LMKSGV-----DGWYKLLGQEEGEYYNVPAIAE-TESIEELTSTIKK------------- AqueK016_Aque IITETCEGQRIESWYKLLGDNISRRKSIRIISD-EE-AEKLIDEYRKTTR-------ANK : . ..*:*:* .. .: : . PKCg_Hsap GP-SSSPIPSPSPSPTDPKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDEL PKCb_Hsap SQ--GTKVPEEKTTNTVSK-FDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL PKCa_Hsap GP-AGNKVISPSE----DR-KQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEEL Pkc53E_Dmel -----K-KPMVMRS---DTNTHTSSKKDMIRATDFNFIKVLGKGSFGKVLLAERKGSEEL inaC_Dmel -------RPNEKRRMDNKDMPHNMSKRDMIRAADFNFVKVIGKGSFGKVLLAERRGTDEL PKCg_Mmus GP-SSSPIPSPSPSPTDSKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDEL PKCb_Mmus GQ--GTKAPEEKTANTISK-FDNNGNRDRMKLTDFNFLMVLGKGSFGKVMLSERKGTDEL PKCa_Mmus GP-AGNKVISPSE----DR-KQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEEL pkc-2_Cele TRDNSSSKPKDPAAPRASTLPLGSSNHNVIKASDFNFLTVLGKGSFGKVLLGEQKTTKEL PKCa_Spur -------LPMPTREASKSQNSNSNSSMGLVRASDFNFLSVLGKGSFGKVMLAEKKGTDEL AqueK016_Aque VA-TLKADIEALDLRRGSQLAPGSKDLPRMTLDDFKLLVVLGKGSFGKVFLAEHKGSKET . : **.:: *:********:*.::: :.* PKCg_Hsap YAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEY PKCb_Hsap YAVKILKKDVVIQDDDVECTMVEKRVLALPG-----KPPFLTQLHSCFQTMDRLYFVMEY PKCa_Hsap YAIKILKKDVVIQDDDVECTMVEKRVLALLD-----KPPFLTQLHSCFQTVDRLYFVMEY Pkc53E_Dmel YAIKILKKDVIIQDDDVECTMIEKRVLALGE-----KPPFLVQLHSCFQTMDRLFFVMEY inaC_Dmel YAVKVLRKDVIIQTDDMELPMNEKKILALSG-----RPPFLVSMHSCFQTMDRLFFVMEY PKCg_Mmus YAIKILKKDVIVQDDDVDCTLVEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEY PKCb_Mmus YAVKILKKDVVIQDDDVECTMVEKRVLALPG-----KPPFLTQLHSCFQTMDRLYFVMEY PKCa_Mmus YAIKILKKDVVIQDDDVECTMVEKRVLALLD-----KPPFLTQLHSCFQTVDRLYFVMEY pkc-2_Cele FAIKVLKKDVIIQDDDVECTMTEKRVLALPE-----KPSFLVALHSCFQTMDRLYFVMEF PKCa_Spur YAIKILKKDVIIQDDDVECTMTEKRVLALPS-----KPAFLTALHSCFQTMDRLFFVMEF AqueK016_Aque YAIKSLKKDLIVQEDDVECTLNERKVLALQG-----KPPFLTSLHSCFQTKEHLFFVMEF :*:* *:**:::* **:: .: *:::*** :* **. :** *** ::*:****: PKCg_Hsap VTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKI PKCb_Hsap VNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKI PKCa_Hsap VNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKI Pkc53E_Dmel VNGGDLMFQIQQFGKFKEPVAVFYAAEIAAGLFFLHTKGILYRDLKLDNVLLDADGHVKI inaC_Dmel CKGGDLMYHMQQYGRFKESVAIFYAVEVAIALFFLHERDIIYRDLKLDNILLDGEGHVKL PKCg_Mmus VTGGDLMYHIQQLGKFKEPHAAFYAAEIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKI PKCb_Mmus VNGGDLMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKI PKCa_Mmus VNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKI pkc-2_Cele VNGGDLMYQIQQVGKFKEPVAVFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLERDGHIKI PKCa_Spur VNGGDLMFQIQKVGKFKEPHAVFYAAEIAVGLFYLHLQGVIYRDLKLDNVLVDAEGHIKI AqueK016_Aque VSGGDLMFHILEFGKFPENQTRFYAAEIVIGLNYLHEKGIVYRDLKLDNVMLDADGHIKI .*****::: : *:* * : ***.*: .* :*: :.::********:::: :**:*: PKCg_Hsap TDFGMCKENVFPGTTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFD PKCb_Hsap ADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE PKCa_Hsap ADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFD Pkc53E_Dmel ADFGMCKENIVGDKTTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLYEMLVGQPPFD inaC_Dmel VDFGLSKEGVTERQTTRTFCGTPNYMAPEIVSYDPYSIAADWWSFGVLLFEFMAGQAPFE PKCg_Mmus TDFGMCKENVFPGSTTRTFCGTPDYIAPEIIAYQPYGKSVDWWSFGVLLYEMLAGQPPFD PKCb_Mmus ADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKSVDWWAFGVLLYEMLAGQAPFE PKCa_Mmus ADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFD pkc-2_Cele TDFGMCKENIFGDATTKTFCGTPDYIAPEIILYQPYGKSVDWWAYGVLLFEMLAGQPPFD PKCa_Spur ADFGMCKEHMNEGDTTRTFCGTPDYIAPEIVAYQPYGKAVDWWAFGVLLYEMLAEQPPFD AqueK016_Aque ADFGLCKDGINADNRTRTFCGTPDYIAPEIISYQPYDQAVDWWALGVLIFEMLIGRPPFD .***:.*: : *:******:*:****: *:**. :.***: ***::*:: :.**: PKCg_Hsap GEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPD---GEPTIRAHGF PKCb_Hsap GEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE---GERDIKEHAF PKCa_Hsap GEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKRLGCGPE---GERDVREHAF Pkc53E_Dmel GEDEEELFAAITDHNVSYPKSLSKEAKEACKGFLTKQPNKRLGCGSS---GEEDVRLHPF inaC_Dmel GDDETTVFRNIKDKKAVFPKHFSVEAMDIITSFLTKKPNNRLGAGRY---ARQEITTHPF PKCg_Mmus GEDEEELFQAIMEQTVTYPKSLSREAVAICKGFLTKHPGKRLGSGPD---GEPTIRAHGF PKCb_Mmus GEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPGKRLGCGPE---GERDIKEHAF PKCa_Mmus GEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPAKRLGCGPE---GERDVREHAF pkc-2_Cele GEDEDELFTAITEHNVSYPKSLSKEAVSLCKALLIKNPSKRLGCTGDDESASRDIKEHPF PKCa_Spur GEDEDELFQSIMEHVPSYPKSMSKESVSMCKGFLTKHPGRRLGCGPT---GEQDIREHQF AqueK016_Aque GDDDDQLFNNIMEKPVHYPRGMSENAKSVVQGFLTKHPRHRLGCDRHK--SPGDIKGHPF *:*: :* * :: :*: :* :: .:: *:* .***. . : * * PKCg_Hsap FRWIDWERLERLEIPPPFRPRPC-GRSGENFD---------------------------- PKCb_Hsap FRYIDWEKLERKEIQPPYKPKAC-GRNAENFD---------------------------- PKCa_Hsap FRRIDWEKLENREIQPPFKPKVC-GKGAENFD---------------------------- Pkc53E_Dmel FRRIDWEKIENREVQPPFKPKIKHRKDVSNFD---------------------------- inaC_Dmel FRNVDWDKAEACEMEPPIKPMIKHRKDISNFD---------------------------- PKCg_Mmus FRWIDWERLERLEIAPPFRPRPC-GRSGENFD---------------------------- PKCb_Mmus FRYIDWEKLERKEIQPPYKPKAC-GRNAENFD---------------------------- PKCa_Mmus FRRIDWEKLENREIQPPFKPKVC-GKGAENFD---------------------------- pkc-2_Cele FRRIDWFKIETRQIQPPFKPKLKTDRSTENFDHSFLKLPTKMTPPDWEVLENLKGDEFSN PKCa_Spur FRRIDWERLANREIQPPFVPTVKNPRAAENFD---------------------------- AqueK016_Aque FASIDWEKLEAKELKPPYKPRIKSNKSHNNFD---------------------------- * :** : :: ** * : .*** PKCg_Hsap ------------------------------------------------------------ PKCb_Hsap ------------------------------------------------------------ PKCa_Hsap ------------------------------------------------------------ Pkc53E_Dmel ------------------------------------------------------------ inaC_Dmel ------------------------------------------------------------ PKCg_Mmus ------------------------------------------------------------ PKCb_Mmus ------------------------------------------------------------ PKCa_Mmus ------------------------------------------------------------ pkc-2_Cele FSFVNPFYVKDVEPHIFYVLFIFLILRPFLLLPYLSHLQLTLSAIHSPLLLLSASVFFKF PKCa_Spur ------------------------------------------------------------ AqueK016_Aque ------------------------------------------------------------ PKCg_Hsap ----------------------------KFFTRAAPALTPPDRLVLASIDQADFQGFTYV PKCb_Hsap ----------------------------RFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFV PKCa_Hsap ----------------------------KFFTRGQPVLTPPDQLVIANIDQSDFEGFSYV Pkc53E_Dmel ----------------------------KQFTSEKTDLTPTDKVFMMNLDQSEFVGFSYM inaC_Dmel ----------------------------DAFTKEKTDLTPTDKLFMMNLDQNDFIGFSFM PKCg_Mmus ----------------------------KFFTRAAPALTPPDRLVLASIDQADFQGFTYV PKCb_Mmus ----------------------------RFFTRHPPVLTPPDQEVIRNIDQSEFEGFSFV PKCa_Mmus ----------------------------KFFTRGQPVLTPPDQLVIANIDQSDFEGFSYV pkc-2_Cele LFKNNFSQSPYNKIKVLLKSADDTSNFDSEFTHEVPKLTPIDRLFLMNLDQTEFEGFSFV PKCa_Spur ----------------------------PYFTKIPCALTPTDKLIIMNI-QEEFHGFTFV AqueK016_Aque ----------------------------KEFTSEKCVLSPVDKHVIEAIDPEAFDGFSFT ** *:* *: .: : * **:: PKCg_Hsap NPDFVHPDARSPTSPVPVPVM PKCb_Hsap NSEFLKPEV----------KS PKCa_Hsap NPQFVHPILQ--------SAV Pkc53E_Dmel NPEYVF-------------SP inaC_Dmel NPEFITI-------------I PKCg_Mmus NPDFVHPDARSPTSPVPVPVM PKCb_Mmus NSEFLKPEV----------KS PKCa_Mmus NPQFVHPILQ--------SAV pkc-2_Cele NPEYVQE-------------C PKCa_Spur NELFDSYVRG--------ASS AqueK016_Aque NPELYVP-------------H *