CLUSTAL W (1.83) multiple sequence alignment PKCt_Hsap MSPFLRIGLSNFDCGSCQSCQGEAVNPYCAVLVKEYVESENGQM-YIQKKPTMYPPWDST PKCd_Hsap MAPFLRIAFNSYELGSLQA-EDEANQPFCAVKMKEALSTERGKT-LVQKKPTMYPEWKST PKCdelta_Dmel ------------------------------------------------------------ PKCt_Mmus MSPFLRIGLSNFDCGTCQACQGEAVNPYCAVLVKEYVESENGQM-YIQKKPTMYPPWDST PKCd_Mmus MAPFLRISFNSYELGSLQV-EDEASQPFCAVKMKEALSTERGKT-LVQKKPTMYPEWKTT tpa-1_Cele MP-----------------------------------------------------E---- PKCd_Spur MV-FLRVRVLQVDSKEIELPGSVLFDPFVAVNVKESVKDANGQTQLRQKRKTAFVEWNKC AqueK017_Aque MSAFLRLKLLKAEVAPAP--GVARVDTFAAVSIKETEQSPQGPV-LVQKKKTFYPEWGKC PKCt_Hsap FDAHINKGRVMQIIVKGK--NVDLISETTVELYSLAERCRKNNG---KTEIWLELKPQGR PKCd_Hsap FDAHIYEGRVIQIVLMRA--AEEPVSEVTVGVSVLAERCKKNNG---KAEFWLDLQPQAK PKCdelta_Dmel ------------------------------------------------------------ PKCt_Mmus FDAHINKGRVMQIIVKGK--NVDLISETTVELYSLAERCRKNNG---RTEIWLELKPQGR PKCd_Mmus FDAHIYEGRVIQIVLMRA--AEDPVSEVTVGVSVLAERCKKNNG---KAEFWLDLQPQAK tpa-1_Cele ---------------------------------------------------WFFLIPQLQ PKCd_Spur FDSHLYDGRVIQVIVYNR--PESYLAEANYKVNELAAMCGMDGR---IETKWLDLMPYGR AqueK017_Aque FDSHLVTGRRMMVEVMDRASPETKIAEMVVETEELSSICKEEPDPSSAINLALDLRPKGK PKCt_Hsap MLMNARYFLE-MSDTKD--------------MNEFETEGFFALHQRRGAI--KQAKVHHV PKCd_Hsap VLMSVQYFLE-DVDCKQ--------------SMRSEDEAKFPTMNRRGAI--KQAKIHYI PKCdelta_Dmel --------------------------------------------NRRGAI--KHQKTHDI PKCt_Mmus MLMNARYFLE-MSDTKD--------------MSEFENEGFFALHQRRGAI--KQAKVHHV PKCd_Mmus VLMCVQYFLE-DGDCKQ--------------SMRSEEEAKFPTMNRRGAI--KQAKIHYI tpa-1_Cele FHNKSKKVSDDDHPVED--------------IMTSRSNSGPGIQRRRGAI--KHARVHEI PKCd_Spur LQVQLRCFPE-EGGGGDPMNSVRSTVSHHNSDMDKKDDTTGLLTKRRVAI--RKAKVHEH AqueK017_Aque LILQVKLYGQ-TSDCPADRT---------PEHLESLPKNATALRGRRNAIHLRQLSVCER ** ** :: PKCt_Hsap KCHEFTATFFPQPTFCSVCHEFVWGL-NKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINS PKCd_Hsap KNHEFIATFFGQPTFCSVCKDFVWGL-NKQGYKCRQCNAAIHKKCIDKIIGRCTGTAANS PKCdelta_Dmel NGHRFVAKFFRQPTFCAFCNLFLWGF-GKQGYQCIICQTVVHKKCHDKLLGKCSGSVFTS PKCt_Mmus KCHEFTATFFPQPTFCSVCHEFVWGL-NKQGYQCRQCNAAIHKKCIDKVIAKCTGSAINS PKCd_Mmus KNHEFIATFFGQPTFCSVCKEFVWGL-NKQGYKCRQCNAAIHKKCIDKIIGRCTGTATNS tpa-1_Cele RGHQFVATFFRQPHFCSLCSDFMWGL-NKQGYQCQLCSAAVHKKCHEKVIMQCPGSAKNT PKCd_Spur RGHKFTPHYFRTPAYCSYCNEFIWGLVGTQGYRCMECELSVHKRCFNQVLGKCPGTGVNS AqueK017_Aque KGHRFVKKFFRQPVYCSYCHEFLWGF-TKPGFQCQVCAYTSHVKCVESIIANCTGATVHA . *.* :* * :*: * *:**: . *::* * * :* :.:: .*.*: : PKCt_Hsap RETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTK PKCd_Hsap RDTIFQKERFNIDMPHRFKVHNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREK PKCdelta_Dmel ASTILLRERFKIDMPHRFKPHTFMSPTFCDHCGSLMGGFFIQGLKCEECDVNCHKKCERL PKCt_Mmus RETMFHKERFKIDMPHRFKVYNYKSPTFCEHCGTLLWGLARQGLKCDACGMNVHHRCQTK PKCd_Mmus RDTIFQKERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKCEDCGMNVHHKCREK tpa-1_Cele KETMALKERFKVDIPHRFKTYNFKSPTFCDHCGSMLYGLFKQGLRCEVCNVACHHKCERL PKCd_Spur TETKKLKERFNINMPHRFKVNNYKSPTFCDHC---------------VCNVNVHHKCKNN AqueK017_Aque TLSKNLKERFKIDMPHRFKPHSFLRPTFCDHCGQLMRGLFRQGVKCGVCGVNCHSRCQPN : :***::::***** .: ****:** *.: * :*. PKCt_Hsap VANLCGINQKLMAEALAMIESTQQARCLRDTEQIFREGPVEIGLPCSIKNEARPPCLPTP PKCd_Hsap VANLCGINQKLLAEALNQVTQRASRR-SDSASS--------------------EPVGIYQ PKCdelta_Dmel TANLCGVNQKLIVEALNHVKRETSYT-YSQFQK---------SGR-----FTA-PATV-- PKCt_Mmus VANLCGINQKLMAEALAMIESTQQARSLRDSEHIFREGPVEIGLPCSTKNETRPPCVPTP PKCd_Mmus VANLCGINQKLLAEALNQVTQRSSRK-LDTT----------------------ESVGIYQ tpa-1_Cele MSNLCGVNQKQLSEMYHEIKRGTHAT-ASCPPNIA---NLHLNGETSKNNGSL-PNKLKN PKCd_Spur VPNLCGVNQRLLSEALSSIEKDKKLPP--GAGN--------------------------- AqueK017_Aque IPNLCGVNERLMAEALKDVDEVKKKR-LSSSSSAGSVVSPKGGAGAIGGAAPKPPLAAIP .****:*:: : * : PKCt_Hsap GKREPQGISWES-------PLDE-VDKMCHLPEP-ELNKERPSLQIKLKIEDFILHKMLG PKCd_Hsap GFEKKTGVAGED-------MQDN-SGTYGKI----------WEGSSKCNINNFIFHKVLG PKCdelta_Dmel -----------------------------------------IPRFKNYSVDDFHFLAVLG PKCt_Mmus GKREPQGISWDS-------PLDG-SNKSAGPPEP-EVSMRRTSLQLKLKIDDFILHKMLG PKCd_Mmus GFEKKPEVSGSD-------ILDN-NGTYGKI----------WEGSTRCTLENFTFQKVLG tpa-1_Cele LF-KSHQYSVEE-------QKETD-EYMDNIWGGG------DGPVKKFALPHFNLLKVLG PKCd_Spur --GK-HGYVPDD-------DEDLDEAVYEPLWTTDGGPPDRPVAVQKYSIDDFMLQKVLG AqueK017_Aque DDHEIYMDVTQDMIKPTVPSRKG-NGAAGRAPPP-PVP--HKPAKPSYKLSDFQLIKVLG : .* : :** PKCt_Hsap KGSFGKVFLAEF-KKTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFC PKCd_Hsap KGSFGKVLLGEL-KGRGEYFAIKALKKDVVLIDDDVECTMVEKRVLTLAAENPFLTHLIC PKCdelta_Dmel KGSFGKVLLAEL-RDTTYYYAIKCLKKDVVLEDDDVDSTLIERKVLALGTKHPYLCHLFC PKCt_Mmus KGSFGKVFLAEF-KRTNQFFAIKALKKDVVLMDDDVECTMVEKRVLSLAWEHPFLTHMFC PKCd_Mmus KGSFGKVLLAEL-KGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLIC tpa-1_Cele KGSFGKVMLVEL-KGKNEFYAMKCLKKDVILEDDDTECTYIERRVLILASQCPFLCQLFC PKCd_Spur KGSFGKVMLAEQ-KGTKKYFAIKALKKEVVLEDDDIECTMVERHVLGLAWAHPFLTHLYC AqueK017_Aque KGSFGKVLLAKLSKGNESYFAIKALKKDVVLEDNDVESTFVEKRILALGSSHPFLTHLLC *******:* : : ::*:*.***:*:* *:* :.* :*:::* *. *:* :: * PKCt_Hsap TFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEIILGLQFLHSKGIVYRDLK PKCd_Hsap TFQTKDHLFFVMEFLNGGDLMYHIQDKGRFELYRATFYAAEIMCGLQFLHSKGIIYRDLK PKCdelta_Dmel TFQTESHLFFVMEYLNGGDLMFHIQESGRFSEERARFYGAEIISGLKFLHKKGIIYRDLK PKCt_Mmus TFQTKENLFFVMEYLNGGDLMYHIQSCHKFDLSRATFYAAEVILGLQFLHSKGIVYRDLK PKCd_Mmus TFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLK tpa-1_Cele SFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTRFYACEIVVALQFLHTNNIIYRDLK PKCd_Spur TFQSKEHLFFVMEYLNGGDLMFHIQSSLRFEEKRARFYAAEIICGLQFLHKRGIIYRDLK AqueK017_Aque SFQTPSHLFFVMEYLNGGDLMFHIQVSHKFKLPRARFYAAEIICALQFLHSKGIIYRDLK :**: . ******:*******.*** :*. *: **..*:: .*:***...*:***** PKCt_Hsap LDNILLDKDGHIKIA--------------------------------------------- PKCd_Hsap LDNVLLDRDGHIKIA--------------------------------------------- PKCdelta_Dmel LDNVLLDYEGHVRIA--------------------------------------------- PKCt_Mmus LDNILLDRDGHIKIA--------------------------------------------- PKCd_Mmus LDNVMLDRDGHIKIA--------------------------------------------- tpa-1_Cele LDNVLLDCDGHIKLA--------------------------------------------- PKCd_Spur LDNVLLDRDGHIKIADFGMCKQNITGETKASTFCGTPDYIAPENTIAEIGGRSGVDRGFY AqueK017_Aque LDNVLLDCDGHAKLA--------------------------------------------- ***::** :** ::* PKCt_Hsap -------------------------------------DFGMCKENMLGD-AKTNTFCGTP PKCd_Hsap -------------------------------------DFGMCKENIFGE-SRASTFCGTP PKCdelta_Dmel -------------------------------------DFGMCKLQIYLD-KTADSFCGTP PKCt_Mmus -------------------------------------DFGMCKENMLGD-AKTNTFCGTP PKCd_Mmus -------------------------------------DFGMCKENIFGE-GRASTFCGTP tpa-1_Cele -------------------------------------DFGMAKTEMNRENGMASTFCGTP PKCd_Spur AAEIICGLQFLHKRGIIYRDLKLDNVLLDRDGHIKIADFGMCKQNITGE-TKASTFCGTP AqueK017_Aque -------------------------------------DFGMCKEGVFAP-NKTGTFCGTP ****.* : :.:***** PKCt_Hsap DYIAPEILLGQKYNHSVDWWSFGVLLYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLE PKCd_Hsap DYIAPEILQGLKYTFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWIT PKCdelta_Dmel DYMAPEIIKGEKYNQNVDWWSFGVLLYEMLIGQSPFSGCDEDELFWSICNEIPWFPVYIS PKCt_Mmus DYIAPEILLGQKYNHSVDWWSFGVLVYEMLIGQSPFHGQDEEELFHSIRMDNPFYPRWLE PKCd_Mmus DYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWIT tpa-1_Cele DYISPEIIKGQLYNEAVDFWSFGVLMYEMLVGQSPFHGEGEDELFDSILNERPYFPKTIS PKCd_Spur DYIAPEILKGQKYAASVDWWSFGVLLYEMLIGQSPFHGEDEDQLFDCILHDAPHFPRWLT AqueK017_Aque DYISPEIVKNERYSYSVDFWSLGVLSYEMLTGQSPFSGDSEEELFDSICNCNVPFPSFLA **::***: . * **:**:*** **** ***** * .*::** .* :* : PKCt_Hsap KEAKDLLVKLFVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPF PKCd_Hsap KESKDILEKLFEREPTKRLGV----TGNIKIHPFFKTINWTLLEKRRLEPPFRPKVKSPR PKCdelta_Dmel AEATGILKGLLEKDYTKRIGSQYSPAGDIADHIFFRPIDWGLLEKRQIEPPFKPQVKHPL PKCt_Mmus REAKDLLVKLFVREPEKRLGV----RGDIRQHPLFREINWEELERKEIDPPFRPKVKSPY PKCd_Mmus KESKDIMEKLFERDPDKRLGV----TGNIRIHPFFKTINWSLLEKRKVEPPFKPKVKSPS tpa-1_Cele KEAAKCLSALFDRNPNTRLGMPECPDGPIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNS PKCd_Spur KDAHSCLIQLLERTPEVRLGV----KGDVRAHQFFKSIDFEKLERRELPPPFKPKIKSDG AqueK017_Aque PSSIDYLKKLLERDPEKRLGCME-DRMPIRSHPFFSPIDWVKLETRESEPPFKPKVKSPG .: : *: : *:* : * :* ::: :* :. ***:*::* PKCt_Hsap DCSNFDKEFLNEKPRLSF-ADRALINSMDQNMFRNFSFMNPGMER-LIS PKCd_Hsap DYSNFDQEFLNEKARLSY-SDKNLIDSMDQSAFAGFSFVNPKFEHLLED PKCdelta_Dmel DTQYFDRVFTRERVRLTP-IDKEILASMDQKQFHGFTYTNPHIT---LD PKCt_Mmus DCSNFDKEFLSEKPRLSF-ADRALINSMDQNMFSNFSFINPGMETLICS PKCd_Mmus DYSNFDPEFLNEKPQLSF-SDKNLIDSMDQEAFHGFSFVNPKFEQFLDI tpa-1_Cele DASNFDDDFTNEKAALTPVHDKNLLASIDPEAFLNFSYTNPHF----SK PKCd_Spur DASNFDPEFTMEKVALSP-TDTSMLSSINQRQFRGFSFTNPTMA---EK AqueK017_Aque DVSNFDDDFTFQEPNLTP-CDNRLVQSIDQSNFRGFSYTNDRI----KI * . ** * :. *: * :: *:: * .*:: * :