CLUSTAL W (1.83) multiple sequence alignment PLK3_Hsap ME--------PAAGF---------------LSPRPFQRAAAA-PAPPAGPGPPPSALRGP PLK2_Hsap MELLRTITYQPAAST--------------KMCEQALGKGCGA-DSKKKRPPQPPEESQPP PLK2_Spur MPLTRSPV-LPVGLSKDVRYTMDQLQKPAPLSPEDTPKTTPSLSSKPHGAGR-EENVKPP PLK5_Mmus MEPR-------------------------------------------------------- PLK2_Mmus MELLRTITYQPAAGT--------------KMCEQALGKACGG-DSKKKRPQQPSEDGQP- PLK3_Mmus ME--------PAAGF---------------LSPRPFPRAAAP-SAPPAGPGPPANASPRS * PLK3_Hsap ELEML------------AGLPTS-DPGRLITDPRSGRTYLKGRLLGKGGFARCYEATDTE PLK2_Hsap QSQAQVPPA-APHHHHHHSHSGP-EISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLT PLK2_Spur -----IPPARAPKAT-PAVSKLP-ELPAVIVDPESGERYRRGRLLG-GGFARCYELTHLD PLK5_Mmus ---------SRRR------RSRQ-LVATFLRDPGSGRVYRRGKLIGKGAFSRCYKLTDMS PLK2_Mmus Q--AQVTPA-APHHHHHHSHSGP-EISRIIVDPTTGKRYCRGKVLGKGGFAKCYEMTDLT PLK3_Mmus EPEVL------------AGPRAPDPPGRLITDPLSGRTYTKGRLLGKGGFARCYEATDTE .: ** :*. * :*:::* *.*::**: *. PLK3_Hsap TGSAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCS PLK2_Hsap NNKVYAAKIIPHSRVAKPHQREKIDKEIELHRILHHKHVVQFYHYFEDKENIYILLEYCS PLK2_Spur THYVYAGKIVPKERISKPSQREKMEREIAVHAQLRHPHIVGFHKHFQDAENIYILLELCR PLK5_Mmus TSAVFALKVVPRGGAGRLRLRGKVEREIALHSRLRHRNIVAFHAHFADRDHVYMVLEYCS PLK2_Mmus NNKVYAAKIIPHSRVAKPHQREKIDKEIELHRLLHHKHVVQFYHYFEDKENIYILLEYCS PLK3_Mmus SGIAYAVKVIPQSRVAKPHQREKILNEIELHRDLQHRHIVRFSHHFEDADNIYIFLELCS . .:* *::*: .: * *: .** :* *:* ::* * :* * :::*:.** * PLK3_Hsap R----KSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITENMEL PLK2_Hsap R----RSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMEL PLK2_Spur H----KSLLHMLKLRKHLTEPEVRYFMLQIIEGVRYLHSHCVIHRDLKLGNMFLTDTMGV PLK5_Mmus RQVPLQSLAHVLKVRRTLTEPEVRYYLRGLVSGLRYLHQQRIVHRDLKPSNFFLNKNMEV PLK2_Mmus R----RSMAHILKARKVLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINEAMEL PLK3_Mmus R----KSLAHIWKARHTLLEPEVRYYLRQILSGLKYLHQRGILHRDLKLGNFFITDNMEL : :*: *: * *: * ******:: ::.*::***.: ::***** .*:*:.. * : PLK3_Hsap KVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPP PLK2_Hsap KVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPP PLK2_Spur KIGDFGLAAKLEFEGDRKRTMCGTPNYIAPEVLGKIGHSFEADVWALGCIMYTMLVGRPP PLK5_Mmus KIGDLGLAARVGPAGRCHRVLCGTPNFQAPEVVSRNGHSCKSDIWALGCIMYTVLTGTPP PLK2_Mmus KVGDFGLAARLEPLEHRRRTICGTPNYLSPEVLNKQGHGCESDIWALGCVMYTMLLGRPP PLK3_Mmus KVGDFGLAARLEPPEQRKKTICGTPNYVAPEVLLRQGHGPEADVWSLGCVMYTLLCGSPP *:**:****:: ::.:*****: :***: : **. ::*:*:***:***:* * ** PLK3_Hsap FETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIDQILRHDFFTKGYT PLK2_Hsap FETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFT PLK2_Spur FETSSLKETYARIKHNKYHFPETLSPVAKEIISDLLSSDPEERPPLEVVIDHEFFTQGFV PLK5_Mmus FAAAPLSEMYQNIRDGHYLEPTHLSPSARSLIARLLAPDPAERPSLDHLLQDDFFSQGFT PLK2_Mmus FETTNLKETYRCIREARYTMPSSLLAPAKHLIASMLSKNPEDRPSLDDIIRHDFFLQGFT PLK3_Mmus FETADLKETYRCIKQVHYTLPASLSLPARQLLAAILRASPRDRPSIEQILRHDFFTKGYT * :: *.* * *:. :* * * *: ::: :* .* :**.:: :: .:** :*:. PLK3_Hsap PDRLPISSCVTVPDLTPPNPARSLFA-KVTKSLFGRKKKS-K------NHAQERDEVSGL PLK2_Hsap PDRLSSSCCHTVPDFHLSSPAKNFFK-KAAAALFGGKKDKARYIDTHNRVSKEDEDIYKL PLK2_Spur PETLSPTACVTAPDFPITKVLISDRKGDLVTNEFCRLKREST---------LQRRDVTAP PLK5_Mmus PERLPPHSCHSPPVFAFPPPLGRLFR-KVGQLLLTQCRPPCP---------FTSK----- PLK2_Mmus PDRLSSSCCHTVPDFHLSSPAKNFFK-KAAAALFGGKKDKARYNDTHNKVSKEDEDIYKL PLK3_Mmus PDRLPVSSCVTVPDLTPPNPARSLFA-KVTKSLFGRKKNKNK------NHSEDQDNVSCL *: *. .* : * : . . : : PLK3_Hsap VSGLMRTSVGHQDARPEAPAASGPAPVSLVETA-P---EDS---------SPRGTLASSG PLK2_Hsap RHDLKKTSITQQPSKHRTDEELQPPTTTVARSG-TPAVENKQQIGDAIRMIVRGTLGSCS PLK2_Spur LSELINNDSSKQGSGTTSQNSGKPSSQPKLRTR-ITGSRPMTPVTSAIKTAMVNVIEKRS PLK5_Mmus -------------------EASGPGEEGTEPDHMEAGNEERDPLCTEGRIHL-LTLGTPR PLK2_Mmus RHDLKKVSITQQPSKHRADEEPQPPPTTVARSG-TSAVENKQQIGDAIRMIVRGTLGSCS PLK3_Mmus VSGLMRTSIGHPDVRPEAPVVSGQAPASLVETA-A---EDS---------SPRGTLASSG . .: . PLK3_Hsap DG--FEEGLTVATVVESALCALRNCIAFMPPAEQNPAPLAQPEP--LVWVSKWVDYSNKF PLK2_Hsap SSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQL-STS--FQWVTKWVDYSNKY PLK2_Spur AAVTMVKSA-SICSMDKVYEMLNTCLEHMPKEDHRTTPKYKPNPSEVVWVIKWVDYSNKY PLK5_Mmus TGLAGPKGS-LALQLEVATRKLFLCLDAGPMAGQDP--PGEQRP--VLWAPKWVDYSLKY PLK2_Mmus SSSECLEDSTMGSVADTVARVLRGCLENMPEADCIPKEQL-STS--FQWVTKWVDYSNKY PLK3_Mmus DG--FEEGLTVATVVESALCALRNCVAFMPPAEQNPAPLAQPEP--LVWVSKWVDYSNKF . :. : . * *: * . . . *. ****** *: PLK3_Hsap GFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSVGAVPRALQPQLGILRY PLK2_Hsap GFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKY PLK2_Spur GFGYQLSNKVVGVMFNDKSRISFTPDRSSVQYLSTDSKVHSFPLSSVPSRLSKKVTLLDY PLK5_Mmus GFGYQLSDGGSGVLFRDGSHMALRPQGGHVSYQPDQGTLWTFTLRDVPSPLRAKLAVLRL PLK2_Mmus GFGYQLSDHTVGVLFNNGAHMSLLPDKKTVHYYAELGQCSVFPATDAPEQFISQVTVLKY PLK3_Mmus GFGYQLSSRRVAVLFNDGTHMALSANRKTVHYNPTSTKHFSFSMGSVPRALQPQLGILRY *******. .*:*.: ::::: .: * * . *. .* : :: :* PLK3_Hsap FASYMEQHLMKGGDLPSVEEVEVPAP---------------PLLLQWVKTDQALLMLFSD PLK2_Hsap FSHYMEENLMDGGDLPSVTDIRRPR----------------LYLLQWLKSDKALMMLFND PLK2_Spur FATYMDEHLIKGIDSDKKDGIRSPSPKRKGVDKPGPVNSAQPYLEKWNRTGKAITMYLSN PLK5_Mmus FACYMQRRLREEGTVPMPATPASPD----------------ISLLSFIADSQAMVMLFSN PLK2_Mmus FSHYMEENLMDGGDLPSVTDIRRPR----------------LYLLQWLKSDKALMMLFND PLK3_Mmus FASYMEQHLMKGGDLPSVEEAEVPAP---------------PLLLQWVKTDQALLMLFSD *: **:..* . * * .: .:*: * :.: PLK3_Hsap GTVQVNFYGDHTKLILSG-WEPLLVTFVARN--RSACTYLASHLRQLGCSPDLRQRLRYA PLK2_Hsap GTFQVNFYHDHTKIIICSQNEEYLLTYINED--RISTTFRLTTLLMSGCSSELKNRMEYA PLK2_Spur GTLQVNFFEDHTKVILSHNNNDHLVTYINES--RTPTTYRVLHITHHGCTKALHTRLSYA PLK5_Mmus GTVQVSLKTSQTQLVLSGEDEDLLLTLQEPGGPAVGVSYTLDVLRSHGFTLAVHHHLRHG PLK2_Mmus GTFQVNFYHDHTKIIICNQSEEYLLTYINED--RISTTFRLTTLLMSGCSLELKNRMEYA PLK3_Mmus GTVQVNFYGDHTKLILSG-WEPLLVTFVARN--RSACTYLASHLRQLGCSPDLRQRLRYA **.**.: .:*::::. : *:* . :: : * : :: :: :. PLK3_Hsap LRLLRDR--------SPA PLK2_Hsap LNMLLQR---------CN PLK2_Spur RHVLYSMMGKGEEDNEKL PLK5_Mmus LHLLQ-----------SV PLK2_Mmus LNMLLQR---------CN PLK3_Mmus LRLLRDQ--------SPA .:*