CLUSTAL W (1.83) multiple sequence alignment PRP4_Hsap MAAAETQ-SLREQ-PEMEDA-NSEKSINEENGEVSEDQSQN--KHSRHKKKKHKHRSKHK PRP4_Mmus MAATEPP-SLREQ-AEMDDADNSEKSVNEENGEVSEDQSQN--KHSRHKKKKHKHRSKHK F22D6.5_Cele MEDNRV-EEDGEVKSDVG--TSSDEKASDSEVEKRQRTDSE--RSGKDKKKKHKKEKKHK Prp4_Ddis MVIESEI-NDKKRG--LES--SSPTI-ND---PKKVKV---------------------- 15575_Tthe MSDKQKKKEDGELSGEEDEYKSPKQKKSDKDDRKKSKRSSRSHSSRRTNDKISDSTKSNK PRP4_Spur MSSNSAS-EEEN----VK--GGAPAS-----KEDSGKQRSH--SSSRHKKHKHKSKKSHH CG7028_Dmel MADDKSY-DSS----------------------------NN--SETEERRAKHKKAKKHK CC1G_04865_Ccin MADASPA-PVEEP--EEETA-PTPPQKSEEE----------------------------- AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque MDSCIFV-IMA------------------------------------ERKLSTG------ PRP4_e_Smoe MGRKRR-SEDCQIS---------------------------------------------- PRP4_d_Smoe MGRRKR-SENYQIR---------------------------------------------- PRP4_b_Smoe MARDGRV-DDAKDK------SRKRKSVEDEQP-----SSKR--REDDDGKRKHK----HR PRP4_a_Smoe MARDGRV-DDAKDK------SRKRKSVEDEQP-----SSKR--REDDDGKRKHK----HR PRP4_c_Smoe MFSETP-LT--------------------------------------------------- PRP4_Hsap KHKHSSEEDKDKKHKHKH------KHKKHKRK--EIIDASDKEGMSP-AKR--------- PRP4_Mmus KHKHSSEEDRDKKHKHKH------KHKKHKRK--EVIEASDKEGLSP-AKR--------- F22D6.5_Cele KDKKHK------------------KEKKHKRE--KEVEM-ENDG-PP-AKKRT------- Prp4_Ddis ------------------------------------------------------------ 15575_Tthe KDKDHK-DSSRRRSKSRSKDRKDQQKRKYSRS--RSRSY-PNDR-NG-TKQRH------- PRP4_Spur KHKHHK-ENKDGHRRHKH------KHKKHKSK--KDEEP---PVATP-AADESESDIELE CG7028_Dmel KHKKSST-GKTEKDRHVH------KKQKKAKKRPHRTSESTNESDAPENAKLKL-----S CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque -DVP-PV-LRTD------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe K------------HKHRS------SHRKHSSK--EADL--DANV-VP-AAMA-------- PRP4_a_Smoe K------------HKHRS------SHRKHISK--EVDL--D--V-VP-AAMA-------- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ------------------------------------------------------------ PRP4_Mmus ------------------------------------------------------------ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe ------------------------------------------------------------ PRP4_Spur DTIPLPKFEPKIPPP----------------------------PPPPNSRRESGRKE--- CG7028_Dmel Q-------------NCGLSSKFTEIMQKASRNGADFRVGKPLLPTDPSSLVEEITKTIQN CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe ------------------------------------------------------------ PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ---------------------------TKLDDLALLEDLEKQRALIKAELDNELMEGKVQ PRP4_Mmus ---------------------------TKLDDLALLEDLEKQRALIKAELDNELMEGKVQ F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis ------------------------------------------------------------ 15575_Tthe ------------------------------------------------------------ PRP4_Spur --------------------------RGRGGD-DTLAALEKQKELLQAQLLATAED--EH CG7028_Dmel KMLPVLEVASSSSESDVPADAASPIILSIIEDELNLEELMRQKALLQARLGAYMSDPE-- CC1G_04865_Ccin ----------------------------------ILAERRARRAAIKAKYEGSRSVVDTA AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque -------------------------------DQ--------------------------- PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe ------------------------------------------------------------ PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap SGMGLILQGYESGSEEEGEIHEKARNGNRSS------------------TRSSSTKGKLE PRP4_Mmus SGMGLILQGYESGSEEEGEIHEKARNGNRSS------------------TRSSSTRGKLE F22D6.5_Cele ----------------------------------------------------------LE Prp4_Ddis -------ESPS-SGKEDGEVDEVTSSP---A------------------SRE-------- 15575_Tthe ----------------------------------------------------------LD PRP4_Spur SGMNLIAQGYQS-DEEEGEDDESALKQSLSKWI--------------------------- CG7028_Dmel -------------AEDKGDLLPHT----HSQQLVVHTKSVLKAVTSVPQPQPSKSAAPLA CC1G_04865_Ccin --PGTPN------------------------------------------PAT--GSQALS AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------CEAEDGEILEPTEDG--------------------------------- PRP4_a_Smoe ------------CEAEDGEILEPTEDG--------------------------------- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap LV--DNKITTKKRSKSRSKERTRHRSDKKKSKGGIEIVKE-KTTRSKSKERK---KSKSP PRP4_Mmus IT--DNKNSAKKRSKSRSKERTRHRSDKRKSKGAGEMLRE-KANRSKSKERR---KSKSP F22D6.5_Cele EVD--------------------------------------------------------- Prp4_Ddis TSS--SKLMSPSKNQSSSSSRSYHDSNN------GYRRKDERYSSSRS-----------Y 15575_Tthe NLY--------------------------------------------------------- PRP4_Spur -R--PESSSSKPSSKSELKDSE--RSEKRKREREDETSQK-KQHRSKSPATE---RSSGS CG7028_Dmel TA--TSKHANIKKST-------THNSNE-----SDVILLD-------------------- CC1G_04865_Ccin TISTTAPSASGTPSG-------VVNEAM-----SKVTLAG-D--------------PGTP AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe -----------------------------------IVLKEE-GNGSSESEKD-------- PRP4_a_Smoe -----------------------------------IVLKEE-GNGSSESEKDVEQEIEAP PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap SK----------RSKSQ-DQARKSKSPTLRRRSQEKIGKARSPTD--------------- PRP4_Mmus SK----------RSKSQ-DQARKSKSPPLRRRSQEKVGKARSPAE--------------- F22D6.5_Cele ------------------------------------------------------------ Prp4_Ddis DR---------------------------------------------------------- 15575_Tthe ------------------------------QRTQIKNGKCNQIYGSQKRNTKFSNDKFLF PRP4_Spur SR----------V-DNG------------------------------------------- CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin TV----------STPGPEFLQRGSASPPP------------------------------- AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe KSERGSPRRSRDGSPPRDNVDRKHSSPDRRH----------------------------- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap ----------------------DKVKIEDKSKSKDRKKSPIINESR-SRDRGKKSRSPVD PRP4_Mmus ----------------------EKMKSEEKGKIKDRKKSPIVNE-R-SRDRSKKSKSPVD F22D6.5_Cele -------------------------TKKDESKKKEAKESSRNNEDEL--------RNP-- Prp4_Ddis -----------------------NYRDRDISRDGDRER---------------------- 15575_Tthe SNSKNLSEAFYIDSYFYSLNSSKKDKDRDNAKEKDRKRSKSPTKDKDRKNDRKRSKSPRS PRP4_Spur ----------------------------------DAKS---------SQSRTNRDSHIAS CG7028_Dmel -----------------------------DSSGGQRTPSPTPEK-R-RRHASPLPAAP-- CC1G_04865_Ccin ----------------------------------------------------------TS AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ------------------------------------------------------------ PRP4_a_Smoe ------------------------------------------------------------ PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap L-RGKS--KDRRSRSKERKSKRSETDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKR-R PRP4_Mmus L-RDKS--KDRRSRSKERKSKRSEIDKEKKPIKSPSKDASSGKENRSPSRRPGRSPKR-R F22D6.5_Cele -----P--RRERSKSAE------------------------------------------- Prp4_Ddis ------------DRDRERDRDR-------------------------------------- 15575_Tthe SNNGKR--KSSRSKSPKRE------------------------------------DS--- PRP4_Spur D-RKHS--KDSDSRRDSRKSSPSATKSEQR----ESRDSREPRDSRKSSGRDGRASPK-R CG7028_Dmel --RSRC-RRDRRSRDRDRS------------------------------------PPR-R CC1G_04865_Ccin A-ADQN---FELAKDGEDDAKRGEIIA--------------------------------- AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe -------------------------------------------------------NARHH PRP4_a_Smoe --RGSSVDRKRRSRSKESVR----------------------------------ENARHH PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap SLSPKPRDKSRRSRSPL-LND-RRSKQSKSPSRTLSPGRR-AKSRSLERKR---REPERR PRP4_Mmus SLSPKLRDKSRRSRSPL-LND-RRSKQSKSPSRTLSPGRR-AKSRSLERKR---REPERR F22D6.5_Cele ----------RRDRE---LRE-RRDA--ERRDRSLSKERR-LIQRKREDNR---RDPRAH Prp4_Ddis ----------DRDRDRDRDRD-RDRERDRDRDR--------DRDRDRDRDRDRDRERERE 15575_Tthe ----------RRDKD---SKSGYRDN--EKKSN-YGSNRDRESRRSEENNT---RESKQL PRP4_Spur ELK--SGEKSRRESSR----D-SKPIRSRSPKKERVFTEP-ARSRPSPPRR---SPPPRR CG7028_Dmel RASDQQ--TQVR--------------------------PR-SRNRNMEDLR---QEINRD CC1G_04865_Ccin -----------NAAEPA-GGD-QINAAD------YDP------SL----DR---REDERK AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe SRVASPDRKRRRSKSRDR-GD-ERSR-----RHAYSPDRR-RRSRSREHDE---R----- PRP4_a_Smoe SRVASPDRKRRRSRSRDR-GD-ERSR-----RHAYSPDRR-RRSRSREHDE---R----- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap RLSSPRTRPRDDILSRRERSKDASPINRW-SPTRRRSRSP-IRRR---SRSPLRRSRSPR PRP4_Mmus RLSSPRTRPRDDILGRCERSKDASPINRW-SPTRRRSRSP-IRRR---SRSPLRRSRSPR F22D6.5_Cele EGN-----RRRDR-------------------------TPE------------RFRNNRD Prp4_Ddis RD--------------RDR-----------NSQERGSRNS-HERDYRD------------ 15575_Tthe TLE--EEEERNDR---YYNDFDDSDSDYYQRVNDRKY-KSSRRSK---S----RSKNRDR PRP4_Spur PPSPPARR-PDQPLGRRGR-----------SPIERRGRSP-LERRIRSSRSPAVVDRFDR CG7028_Dmel KQRERRDHS---------RDRDRRGLDRPPPPTDMR---P-GRAR---ERD-VRPSRMQR CC1G_04865_Ccin RFG--------------------------------------------------------V AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe -------------------------------------------------------EKYPR PRP4_a_Smoe -------------------------------------------------------EKYPR PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap RRSRSPRRR---DRGRRSRS-RLRRRSR-SRGGRR------------------RRSRS-- PRP4_Mmus RRSRSPRRR---DRSRRSRS-RLRRRSR-SRGGHR------------------RRSRS-- F22D6.5_Cele RRDRDGRRE---DRHRRSPD-RRRDSDR-KREDGK------------------R------ Prp4_Ddis -------NR---DYSRDSRD-NMDSRDN-KNGSRQSINNNTLSYEKQADRKDEVRVKDNI 15575_Tthe KKSKSKGRK---DDKNKDKD-KERSKNS-GNGDNS------------------K------ PRP4_Spur RRGASPPRRFG-DM-SRNRRRWSRSPDRRGRRGRW------------------GRSRS-- CG7028_Dmel SHSRSKFES---DR-RR--E-RERQKDR-DRGGGR------------------VGARSGT CC1G_04865_Ccin ------------DQ--------------AANGT--------------------------- AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe KRAESRDRHIKDDRGARDDE-RHYNRDR-SRQ-----------------------N---- PRP4_a_Smoe KRAESRDRHIKDDRGARDDE-RHYNRDR-NRR-----------------------DRE-- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap -KVKEDKFKGSLSEGM---KVE-QESSSDD---NLEDFDV-E--EEDEEALIEQRRIQRQ PRP4_Mmus -KVKEDKFKGSLSEGM---KVE-QESSSDD---NLEDFDV-E--EEDEEALIEQRRIQRQ F22D6.5_Cele ----------------------KDESKDVE---W--NLDS-D--SDDEQKKIEAARKRRI Prp4_Ddis S-VNDDKT--NHGENLTNESI-TATSTNEP---TKPAVIIEEDEETKTKRILEENRLQRQ 15575_Tthe --SSKDKKE---EEA---KKAQQPETIDDD---EDLNMEI-E--DSD-----DERERKKQ PRP4_Spur -KSPRDKFKGSLSEGL---SLK-QESSDDE----IPDVDLDE--EEDEEAVIERRRRERQ CG7028_Dmel DNGDRDRYKGSLSEGQ--NKLD-KESSDEE---VNVNIDILE--EDDEERIIELRRKKRE CC1G_04865_Ccin ----NHHVNGQSGSAI---DVD-MEDEDED---DEADEES-E--EEDLDD---------- AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ---------------------------------------LMS--EDEVKEIK-------- PRP4_e_Smoe ---------------------------------------VVEDEDAMVERVREESRKRRQ PRP4_d_Smoe ---------------------------------------VEEDEDAMVERVREESRKRRQ PRP4_b_Smoe --------------------------QDEYLERVAHQLA-EQ--EEDIEKVKEESRKRRQ PRP4_a_Smoe -ELS-EKQETTQSETI---ERE-EENQDEYLERVAHQLA-EQ--EEDIEKVKEESRKRRQ PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap AIVQKYKYL---AEDSN-----M----SVP------SEPSS--------PQSSTRT--R- PRP4_Mmus AIVQKYKYL---AEDSN-----I----SVP------SEPSS--------PQSSTRS--R- F22D6.5_Cele QIIKKIEGH---TEENTP-RDSS----TPR------SDTIGDKKTDESEDSSS------- Prp4_Ddis LIMEKYNKE---QPQPIT-SSLS----TTE------KEQSNTNTNSNSTPVATTTT--SI 15575_Tthe EFLNMIKVQGMQMQKQEA-SQTF----SKE------NNQNNQTQNKNDQDVVDDKL--K- PRP4_Spur QLMQKYKVA---PAESAT-SSPA----QGP------SEPSST----PQSPQASEQGGST- CG7028_Dmel ELLKKLGTG---QESPAP-HNSV----SYE------SRSTSQGSSQRERPLRTPSP--T- CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe AILEKHALE---EGQIIE-QQSVSLGNPVP------HDTAK--------I---------- PRP4_d_Smoe AILEKHALE---EGQIVE-QESVSLGNPVP------HDTAK--------I---------- PRP4_b_Smoe AILEKHKMQ---QNSG-------------------------EGIIDPSTPLSLGKS--A- PRP4_a_Smoe AILEKHKMQ---QSQPEEPAETM----KVSKPLTAAEPDSGEGIIDPSTPLSLGKS--A- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap -S-PS-----PD----DILE---------------------------------------- PRP4_Mmus -S-PS-----PD----DILE---------------------------------------- F22D6.5_Cele ---DS-----ED----DE---DDRKLAEAKDLIKST-RFGSEQGSGASTPVSIQSDNDTP Prp4_Ddis LA-KS-----PS----NLENQIEEEDESI------------------------------- 15575_Tthe -VKDS-----ENLENQNF---ADENSEEQ------L-F---------------DDTGLNP PRP4_Spur -A-QSQDTDDED----DDEE-EEEEDEEE------DDSE--------------KSSSSDS CG7028_Dmel -M-PC-----PN----PLIS---------------------------------------- CC1G_04865_Ccin ------------------------------------------------------------ AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe -L-PN-----G-----TILK---------------------------------------- PRP4_a_Smoe -L-PN-----G-----TILK---------------------------------------- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap -----RV-A-----------------------AD----V----K----EYERENVDTFE- PRP4_Mmus -----RV-A-----------------------AD----V----K----EYERENVDTFE- F22D6.5_Cele TDFFSGL-RDKMVHMKDADEHNVDEVLQ-----R----G--K-D----EEYREDWHTQLK Prp4_Ddis ------I-I---EWRKDQNSENSSAFNDNNNDES----C--SSE----EDLKKRGKIKE- 15575_Tthe NDVLDDDDVNIANTINDDYKEEVDESHS-----LTHRHSIDK-AQLDHLKFLED----MR PRP4_Spur DDDSSEV-ESKASSDDDDDDEEDDEGDA----AR----I----E----EEERLREEEEE- CG7028_Dmel -----EI-P-----------------------K-----------------DREDMDNS-- CC1G_04865_Ccin -------------------------MFA----VA----L--G-G----DEEK-------- AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe -----RNA------------------------GG----L----G----EGSPPKVR---- PRP4_a_Smoe -----RNA------------------------GG----L----G----EGS--------- PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap --------------ASVKAKH-----------------------------------NLMT PRP4_Mmus --------------ASVKAKH-----------------------------------NLMT F22D6.5_Cele E----------QEKREEEEKKKKLEAEAAA-------------EA--------------- Prp4_Ddis --------------EDIKAKDKPITTTTTTTT----------IN------------NVSI 15575_Tthe NQEIKGGIPDMPEQPILKQKRKSINSEKLEGKFSNNDQLDEENKL--------------- PRP4_Spur --------------AE-QEKRREMERKRLKEAFPQSDSEDEESAANSKKGEGSLDKNLSD CG7028_Dmel ------------------------------------------------------------ CC1G_04865_Ccin --------------PK-KKKKKATGKKK-------------------------------- AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ------------------------------------------------------------ PRP4_e_Smoe ------------------------------------------------------------ PRP4_d_Smoe ------------------------------------------------------------ PRP4_b_Smoe ---------------------------------------------------ICLRKNLL- PRP4_a_Smoe ------------------------------------------------------------ PRP4_c_Smoe ------------------------------------------------------------ PRP4_Hsap VEQN---NGSSQKKLLAPDMFTESDDMFA--AYFDSARLRAAGIG---KD-FKENPNLRD PRP4_Mmus VEQN---NGSSQKKILAPDMFTESDDMFA--AYFDSARLRAAGIG---KD-FKENPNLRD F22D6.5_Cele ----AK-KKKQEEDDTGFDMFADNEE---------LPQDSTTIDG---HS-GAVHDTLKD Prp4_Ddis KLPPKPEPIKAKTSAPVFDMFSDSPSDETDESNRDLNETNGGGVMVDANIVVNPSINLSD 15575_Tthe ----HK-LDDQEDSEEETDMFGDDID---------KIINKS-NDG---KL-QIVK-GANA PRP4_Spur IVKPKS-DKEQAMANNGLDMFSEVDM-FK-----MSP-STREGIG---QM-GPENPSLTD CG7028_Dmel TSQK---TCSAKEKRNEWDMFADQDVDS----NFDSPN--TIVQN---KH-QHENPALTD CC1G_04865_Ccin ---------------------------------------TKENAA---QT-LGAPNVIVD AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ---T---GLSAMKTAVVLDIFSEEDITGKE-KSWLSPS--KALLA---DG-IGENDHLTD PRP4_e_Smoe -ASN---SCDKSSSPPAQDMFSETPLAEIT-----NP----EASV---Q---GLRNDNPD PRP4_d_Smoe -ASN---SCDKSSSPPAQDMFTETPLAEII-----NP----EASG---Q---GVRNDNPD PRP4_b_Smoe I--SSS-LQSEKPADMFCDIFGESPA-----------EIRKAGTR---DTLAIDTSGLTD PRP4_a_Smoe -----P-PKSEKPADMFCDIFGESPA-----------EIRKAGTR---DTLAIDTSGLTD PRP4_c_Smoe ---------------------------EIT-----NP----EASV---Q---GLRNDNPD PRP4_Hsap NWTDAEGYYRVNIGEVLDK-RYNVYGYTGQGVFSNVVRARDNA--------------RAN PRP4_Mmus NWTDAEGYYRVNIGEVLDK-RYNVYGYTGQGVFSNVVRARDNA--------------RAN F22D6.5_Cele NWDDVEGYYRVRIGELLDT-RYRVVGFTGAGVFGNVCRCNDQT--------------KG- Prp4_Ddis NWDDADGYYKFRVGEIMD--KYQIFSPIGSGVFSTVVSAKETK---------------TN 15575_Tthe ECDDEQNYFKILIGEVLNG-KYRVIQKCGKGVFANVCKAEQLD--------------NG- PRP4_Spur NWDDEEGYYRVRIGESLDK-RYAVYGYTGQGVFSNVVRARDTA--------------RGK CG7028_Dmel NWDDAEGYYRVRIGEVLDN-RYLVNGYTGQGVFSNVVRGRDQA--------------RGQ CC1G_04865_Ccin AAADPEGYYRVILGERIDNGRYQVFSSLGQGMFANVVRARVLKDENGKDLAVDGVAPESL AqueK115_Aque ----------VRIGEQLDR-RYMVYGYTGQGVFSNVVRARDTS--------------RSS AqueK116_Aque NWDDAEGYYRVRIGEQLDR-RYMVYGYTGHGVFSNVVRARDTS--------------RSS PRP4_e_Smoe NWHDHEFYYKARIGETINS-KYQVKASIGSGMFSTVFLAKSLFP-------------ECE PRP4_d_Smoe NWHDQEFYYKARVGETINS-KYQVKASIGSGMFSTVFLAKSLLP-------------ECQ PRP4_b_Smoe NWDDADGYYTYRVGEVLDN-RYEIASSHGRGVFSTVVRARDTKAGR-----------GEP PRP4_a_Smoe NWDDADGYYTYRVGEVLDN-RYEIASSHGRGVFSTVVRARDTKAGR-----------GEP PRP4_c_Smoe NWHDHEFYYKARIGETINS-KYQVKASIGSGMFSTVFLAKTLLP-------------ECE :** :: :* : * *:*..* . PRP4_Hsap QEVAVKIIRNNELMQKTGLKELEFLKKLNDA--DPDDK-FHCLRLFRHFYHKQHLCLVFE PRP4_Mmus QEVAVKIIRNNELMQKTGLKELEFLKKLNDA--DPDDK-FHCLRLFRHFYHKQHLCLVFE F22D6.5_Cele NTVAVKIIRNNEVMYKTGLRELEVLRKLNEA--DKEDK-YHCLRLFRTFKHHNHLCLVFE Prp4_Ddis EDVVIKIIRNRPSMHRSGLKEIEILQKISNTPTSSNQK-SHCIQMKDHFNYRNHLCIVFE 15575_Tthe KMVAIKILRSNEIMRDSGEREKEIIQKLNLN--DKNDR-KHIVRLKNVFEHQKHMCLVFE PRP4_Spur LDVAIKIIRNNDLMQKTGMKELEYLKRLNDQ--DREDK-FHCVRLFRSFSYRQHLCLVFE CG7028_Dmel ANVAIKIIRNNEIMHKTGLRELEILKKLNDA--DPEDR-FHCLRLYRHFFHKQHLCMVFE CC1G_04865_Ccin REVAIKIIRSQESMYKAGLKEAQILQKLRAL--DPEDK-KHIVKLERTFEHRGHLCLVFE AqueK115_Aque QEVAIKIIRNNEMMHKTGMAELEILKKLNAT--DPDDK-FHCIRLFSNFFHKNHLCLVFE AqueK116_Aque QEVAIKIIRNNEMMHKTGMAELEILKKLNAT--DPDDK-FHCIRLFSNFFHKNHLCLVFE PRP4_e_Smoe QEVAIKIPRKNDLMLRSAKSELQILKKVAEP--EATNKDNHCVKLLDSFVYREHLCLVME PRP4_d_Smoe QEVAIKIPRKNDLMLRSAKSELQILKKVAEP--EATNKDNHCVKLLDSFVYREHLCLVME PRP4_b_Smoe EEVAIKIIRSNETMFKAGQMELIILNKLAGA--DLENK-RHCVRLLSSFEYRNHLCLVFE PRP4_a_Smoe EEVAIKIIRSNETMFKAGQMELIILNKLAGA--DLENK-RHCVRLLSSFEYRNHLCLVFE PRP4_c_Smoe QEIAIKIPRKNDLMLRSA-------------------------------KYREHLCLVME :.:** *.. * :. :: *:*:*:* PRP4_Hsap PLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKT PRP4_Mmus PLSMNLREVLKKYGKDVGLHIKAVRSYSQQLFLALKLLKRCNILHADIKPDNILVNESKT F22D6.5_Cele NLSMNLRELLKKYGQKDGLHLKAVRSYAQQLLLALRLLKKLEFVHADIKPDNILVNESKL Prp4_Ddis PMSMSLHQLIKKYGKDIGLSLNAVRVYAKQLFLALKHIKNSKILHADIKPDNIVVNEAKN 15575_Tthe CFAMNLRDALKEYGKGKGFSLDVVRSYAYQIFVALTHLKKNNYIHADLKPDNLLISEDTK PRP4_Spur PLSMNLREVLKRYGKDVGLHIKAVRSYTQQLFLALKLLKRCNILHADIKPDNILVNESKS CG7028_Dmel PLAMNLREVLKKYGKNVGLHIKAVRSYTQQLFLALKLLKKTGILHADIKPDNILVNENNL CC1G_04865_Ccin NLSMNLREVVKRFGKDVGLNIRAVRAYAHQLFLALSLLRKANIMHADIKPDNILVNEQKN AqueK115_Aque SMSMNIREVLRKYGKNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKL AqueK116_Aque SMSMNIREVLRKYGKNIGLHIKAVRSYSQQLLLALKLMKRCTILHADIKPDNILVNESKL PRP4_e_Smoe SLDLNLRQITNKYGRNRGINLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVTKSRR PRP4_d_Smoe FLDLNLRQITNKYGRNRGINLKTICVYAHQLMVALQHLAHCGILHCDIKPDNIMVTKSRR PRP4_b_Smoe SLHMNLREILKKFGRNIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDSKN PRP4_a_Smoe SLHMNLREILKKFGRNIGISLAAVRSYARQLFTALKHLRNCGVLHCDIKPDNMLVNDSKN PRP4_c_Smoe SLDLNLRQITNKYGRNRGINLKTICVYAHQLMVALQHLAHCGIFHCDIKPDNIMVTKSRR : :.::: ..:*: *: : .: *: *:: ** : . .*.*:****:::.. PRP4_Hsap ILKLCDFGSASHVADN---DITPYLVSRFYRAPEIIIGK-SYDYGIDMWSVGCTLYELYT PRP4_Mmus ILKLCDFGSASHVADN---DITPYLVSRFYRAPEIIIGK-SYDYGIDMWSVGCTLYELYT F22D6.5_Cele TLKLCDFGSAGRVNEQ---ELAPYLVSRFYRAPEIMLGV-RHDYAIDLWSVAVTLYEVYT Prp4_Ddis TIKIVDFGSAGEIHES---EITPYLVSRFYRAPEIILGH-KYDYSIDVWSVGCCLAEFFT 15575_Tthe TLKMCDFGTALPIEEN---GIIKYLQSRFYRAPEVLIGY-PPYNQIDVWSVGVTLYEIYT PRP4_Spur VLKLCDFGSASHVADN---DITPYLVSRFYRAPEIIIGM-NYDAAIDMWSTGCTIFELAA CG7028_Dmel ILKLCDFGSASAISDN---EITPYLVSRFYRSPEIILGI-PYDYGIDTWSAGCTIYELYT CC1G_04865_Ccin LIKLCDLGSASDASEN---EITPYLVSRFYRAPEIILGV-PYDPALDVWSIGCTLYELYT AqueK115_Aque MLKLCDFGSASFIQDN---EITPYLVSRFYRAPE-------------------------- AqueK116_Aque MLKLCDFGSASFIQDN---EITPYLVSRFYRAPEIIIGC-KYDYGIDMWSVGATLYELYT PRP4_e_Smoe SIKLCDFGVAMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHAIDMWSAGCCLYELYT PRP4_d_Smoe SIKLCDFGVAMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHPIDMWSAGCCLYELYT PRP4_b_Smoe LLKLCDFGSAMFAGEN---EITPYLVSRFYRAPEIILGL-PYDHALDMWSVGCCLYELYT PRP4_a_Smoe LLKLCDFGSAMFAGEN---EITPYLVSRFYRAPEIILGL-PYDHALDMWSVGCCLYELYT PRP4_c_Smoe SIKLCDFGVAMFARDQTPSAETPYLVSPSYRAPEIILGVAPYSHQIDMWSAGCCLYELYT :*: *:* * :. ** * **:** PRP4_Hsap GKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREK-- PRP4_Mmus GKILFPGKTNNHMLKLAMDLKGKMPNKMIRKGVFKDQHFDQNLNFMYIEVDKVTEREK-- F22D6.5_Cele GKIMFPGRTNNHMLKLFTDVKGKYPNKLVRKSQFKDTHFDVNCNLLYQEVDKVTERNK-- Prp4_Ddis GKFLFPGKTNNDMIRLFMEYRGAFSKKMLKKSEFVSNHFNENLVFMKQEIDNIEKTVR-- 15575_Tthe QKILFDGSTNNEMLKLIMDSRGKFNKKMLQNGKYVEEYFDQNYNFKYTYVDKQTNQKY-- PRP4_Spur GKIMFPGKTNNHMLKLFMDLKGKMPHKIIRKGILRDKHFDPNCNFKYVEVDKVTEREK-- CG7028_Dmel GKILFSGKSNNQMLKFFMDVKGKIPNRIIRKGQFREQHFDQSCNFLYHEIDKLTEREK-- CC1G_04865_Ccin GKILFPGRSNNQMLRLMMELKGRFNTKIIKKAKFGETYFDELGAFESVERDRLTGSDI-- AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque GQILFPGKSNNEMLKLNMELKGKMSHKMVRKGMFRENHFDSSFNFLYHTVDKVTQKEK-- PRP4_e_Smoe GKFLFPVATNNGLLKQQMELKGAFPKAMLKKGAFTGMHFNENFEF--RQLDPVTKLET-- PRP4_d_Smoe GKFLFPVATNNGLLKQQMELKGAFPKAMLKKGAFTGMHFNENFEF--RQLDPVTKLET-- PRP4_b_Smoe GKVLFPGSTNNDMLRLHMELKGPFPKKMLRKAMFTAQHFDQDLNFHAIEEDPVTKKTI-- PRP4_a_Smoe GKVLFPGSTNNDMLRLHMELKGPFPKKMLRKAMFTAQHFDQDLNFHAIEEDPVTKKVQFC PRP4_c_Smoe GKFLFPVATNNGLLKQQMELKGAFPKAMLKKGAFTGMHFNENFEF--RQLDPVTKLET-- PRP4_Hsap ----------------VTVMSTI-NPTKDLLADLIGCQ--RLPEDQRKKVHQLKDLLDQI PRP4_Mmus ----------------VTVMSTI-NPTKDLLADLIGCQ--RLPEDQRKKVHQLKDLLDQI F22D6.5_Cele ----------------ITVLANL-KPTRDLESELIAG--QRLSRDQMDQIQAFRTLLDGM Prp4_Ddis ----------------KVPHDIT-KPTKDILQFLLPK-NVSIPDQDMKKLIQLKDLIEKC 15575_Tthe ----------------TTIITYGDIPKKDIYRLLQEN-KDGINLENQKKLSQFKDFLDKC PRP4_Spur ----------------VTVMTVI-NPTKDLTTELLGYQ--RLPEDQQRKVLQLKDVLDRC CG7028_Dmel ----------------IVVMPVV-KPSRSLQQELIADQ--NLPDDQHRKVTQLKDLLENM CC1G_04865_Ccin ----------------TRKIHIQ-KPTRDLRARLMPSSSVKLNDEETKMLANFIDLLDKC AqueK115_Aque ------------------------------------------------------------ AqueK116_Aque ----------------VVVMSSF-SPQRDLLADLVGSQ--SPSEAHLRKIHHFKDFLDKI PRP4_e_Smoe ----------------LRSMASF-NVKTSCISDLTG--------EDGALMARFKNLLERM PRP4_d_Smoe ----------------LRSMASF-NVKTSCISDLTG--------EDGALMARFKNLLERM PRP4_b_Smoe ----------------NRMITNV-KP-KDI-STLISSS--GGSDEDAKNLLNFKLLLEKI PRP4_a_Smoe IFPVYSFLHLLSFQTINRMITNV-KP-KDI-STLISSS--GGSDEDAKNLLNFKLLLEKI PRP4_c_Smoe ----------------LRSMASF-NVKTSCLSDLTG--------EDGALMSRFKNLLERM PRP4_Hsap LMLDPAKRISINQALQHAFIQE-------KI PRP4_Mmus LMLDPAKRISINQALQHAFIQE-------KI F22D6.5_Cele LILDPSKRTTCNEALKHPFFTI------PIK Prp4_Ddis TILDPEKRITPFEALNHEFLK--------PF 15575_Tthe LQLDPKNRITPEEALEHPFLKLNTTNPTKPK PRP4_Spur LMLDPSKRISINEVLRHSFIQE-------KI CG7028_Dmel FALDPAKRISLNQALVHPFIQE-------KM CC1G_04865_Ccin LMLDPARRITPREALSHPFIR---------G AqueK115_Aque ------------------------------I AqueK116_Aque FILDPTKRLSINQALQHPFIIE------KLD PRP4_e_Smoe LTLDPSKRITPDEALKHPFLKS------VCK PRP4_d_Smoe LTLDPSKRITPDEALKHPFLKS------VCK PRP4_b_Smoe FILDPEKRLTVSQALNHPFIN---------K PRP4_a_Smoe FILDPEKRLTVSQALNHPFIT---------K PRP4_c_Smoe LTLDPSKRITPDEALKHPFLKS------VCK