CLUSTAL W (1.83) multiple sequence alignment SIK_Hsap MVIMSEFSAD-------------------------------------------------- QSK_Hsap MAAAAASGAGGA--AGAGTGGAG------------------------------------- QIK_Hsap MVMAD------------------------------------------------------- CG15072_Dmel MATTPTA--GPAA----------------------------------------------- kin-29_Cele MAAP-------------------------------------------------------- QIK_Mmus MVMAD------------------------------------------------------- QSK_Mmus MAAAAASGAGGV--AVAGAGGAG------------------------------------- SIK_Mmus MVIMSEFSAV-------------------------------------------------- DDB0231454_Ddis MNTHNNNY------QQRSMDSAIVTINDKGYIQSVDRKTCELFGYTIEELQLQKVNILVP QSK_Spur ------------------------------------------------------------ SIK_Spur MVVMEEKADT-------------------------------------------------- CG4290_Dmel MSTCEAAAAGENGSQAKSEESQP------------------------------------- AqueK068_Aque LALKLQKETRRV------------------------------------------------ AqueK069_Aque MDL--------------------------------------------------------- SIK_Hsap ------------------------------------------------------------ QSK_Hsap -PA--------------------------------------------------------- QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus -PA--------------------------------------------------------- SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis SPYKEQHDTYMQSYFETGVRKIIDKSRVVEGLHKDGSVFPITLSVTEVRIWNKRMFIGSI QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel -PE--------------------------------------------------------- AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque ------------------------------------------------------------ SIK_Hsap ------------------------------------------------------------ QSK_Hsap -----------------------------------------GRLLPPPA---PGSPAAPA QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ---------------------------------------------------------APP kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus -----------------------------------------GRLLPPPA---AGPPAAPA SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis ESIIDKRLIIYTDVHGIITYCNRNVEELIGYTPAELFGKNVS------------------ QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel -----------------------------------------DQKKKQPQHERNEKQLDKP AqueK068_Aque -----------------------------------------------------------I AqueK069_Aque ------------------------------------------------------------ SIK_Hsap ------------------------------------------------------------ QSK_Hsap -AVSPAAGQ--------------------------------------------------- QIK_Hsap ------------------------------------------------------------ CG15072_Dmel TSSTPQNYK--------------------------------------------------- kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus -AVPPAAVP--------------------------------------------------- SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis -----------------ALMPSP------------HAKSHSEYIEKNYHGGGLWKMLNRV QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel PENLPQNGKTEAKGAEGACSHPPLDALRSSVLLDAGA----------------------- AqueK068_Aque -TTMDHRLS--------------------------------------------------- AqueK069_Aque ------------------------------------------------------------ SIK_Hsap ------------------------------------------------------------ QSK_Hsap ------------------------------------------------------------ QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus ------------------------------------------------------------ SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis RNLPIKHKSGVVFLVSILVTKISTDGIDMFKAIIQTPPKEAVFTINGDGIIKACNFNFTE QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque ------------------------------------------------------------ SIK_Hsap ------------------------------------------------------------ QSK_Hsap ------------------------------------------------------------ QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus ------------------------------------------------------------ SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis PMFGYTQKDLLGNTIGLLIPEMSKIIDNTSLNLTDSHDPQLQQQQQTTTTTTTTTTTTS- QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------ASP----------------SIDAI AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque ------------------------------------------------------------ SIK_Hsap ------------------------PAG--------------------------------- QSK_Hsap ----------------------PRPPA--------------------------------- QIK_Hsap --------------------------G--------------------------------- CG15072_Dmel -----------------------VPST--------------------------------- kin-29_Cele ------------------------------------------------------------ QIK_Mmus --------------------------G--------------------------------- QSK_Mmus ----------------------ARPTA--------------------------------- SIK_Mmus ------------------------PSG--------------------------------- DDB0231454_Ddis --------------TTSTTTSTPTPASIAVSGNNISSPPIDSPLTTPSTPTTFNHSRGVE QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------PT---------------------------------- CG4290_Dmel VACKDALLAQKLFASGGGSTPGPSPTSSAVGAGGIS--------------GK-------- AqueK068_Aque ----------------------IMSTA--------------------------------- AqueK069_Aque ------------------------------------------------------------ SIK_Hsap ------------------------------------------------------------ QSK_Hsap ------------------------------------------------------------ QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus ------------------------------------------------------------ SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis SWLGRTRKVDVWHRDGSRFPVNLEIIKLQGENSMFSLQIKKVENPRVYGKDKDKNGGGGG QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque ------------------------------------------------------------ SIK_Hsap ------------------------------------------------------------ QSK_Hsap ------------------------------------------------------------ QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus ------------------------------------------------------------ SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis TTENKDGKQLDTIKESKEHRHSKEKKKRKKDRDHNNNNNNNNNNNNNNNEQTSDSSDSSD QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque ------------------------------------------------------------ SIK_Hsap -------------------------------------------------------Q-GQG QSK_Hsap -------------------------------------------------------P-ASR QIK_Hsap -------------------------------------------------------P-RHL CG15072_Dmel -------------------------------------------------------S-KIS kin-29_Cele ----------------------------------------------------------RR QIK_Mmus -------------------------------------------------------P-RHL QSK_Mmus -------------------------------------------------------P-ASR SIK_Mmus -------------------------------------------------------T-GQG DDB0231454_Ddis SDSESRSKKKRSSKKKSRRDDSSSDSSDSETESSSSPHKKNRSSNSSSNSSHSNAPHESS QSK_Spur ------------------------------------------------------------ SIK_Spur -------------------------------------------------------Q-AKP CG4290_Dmel -------------------------------------------------------D-LLK AqueK068_Aque -------------------------------------------------------I-PES AqueK069_Aque ------------------------------------------------------------ SIK_Hsap QQKPLRVGFYDIERTLGKGNFAVVKLARHRVTKTQVAIKIIDK-TRLDSSNLEKIYREVQ QSK_Hsap GPMPARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDK-TQLDEENLKKIFREVQ QIK_Hsap QRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDK-SQLDAVNLEKIYREVQ CG15072_Dmel VDKLLRVGYYELEKTIGKGNFAVVKLATNIVTKTKVAIKIIDK-TCLNEEYLNKTFREIA kin-29_Cele RMGLEKIGLYDVGRAIGKGNFATVRIARHKIAKTKVAIKSIDV-SALDRENLIKLEREVK QIK_Mmus QRGPVRVGFYDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDK-SQLDAVNLEKIYREVQ QSK_Mmus GSMAARIGYYEIDRTIGKGNFAVVKRATHLVTKAKVAIKIIDK-SQLDEENLKKIFREVQ SIK_Mmus QQKPLRVGFYDVERTLGKGNFAVVKLARHRVTKTQVAIKIIDK-TRLDSSNLEKIYREVQ DDB0231454_Ddis YYQPEMIGEYTLGKTLGRGNYGVVKLGTHINTKEEIAIKILYK-EQMTESEFTRCKREIE QSK_Spur ----------------------------------QVAIKIIDK-TQLEGDNIQKIVREVK SIK_Spur RRGHIRVGFYDIDRTIGKGNFAVVKLAKHRITKSQVAIKIIDK-SRLDESNLKKVYREVQ CG4290_Dmel LKEPMRVGFYDIERTIGKGNFAVVKLARHRITKNEVAIKIIDK-SQLDQTNLQKVYREVE AqueK068_Aque IANQSRIGYYELEKVIGRGNFAIVKLATHTVSKMKVAIKIIDK-SRLDKENLKKVQREVE AqueK069_Aque -EGCLVGGVYEVKRRLQSGYFGVTWLAENKTTNRDVCLKTFFNESQS-------QRKELV .:.:* : :*: SIK_Hsap LMKLLN-----HPHIIKLYQVMETK------------DMLYIVTEFAKNGEMFDYLTSNG QSK_Hsap IMKMLC-----HPHIIRLYQVMETE------------RMIYLVTEYASGGEIFDHLVAHG QIK_Hsap IMKMLD-----HPHIIKLYQVMETK------------SMLYLVTEYAKNGEIFDYLANHG CG15072_Dmel ILKSLR-----HPHITRLYEVMESQ------------SMIYLVTEYAPNGEIFDHLVANG kin-29_Cele IVKVID-----HPHIVKSYEIMRVD------------NMLYIVSEYCSSGELYETLIEK- QIK_Mmus IMKMLD-----HPHIIKLYQVMETK------------SMLYLVTEYAKNGEIFDYLANHG QSK_Mmus IMKMLC-----HPHIIRLYQVMETE------------RMIYLVTEYASGGEIFDHLVAHG SIK_Mmus LMKLLN-----HPNIIKLYQVMETK------------DMLYIVTEFAKNGEMFDYLTSNG DDB0231454_Ddis ILKQLY-----HPFINKLLNVLEKD------------DAMFILMDYCQGGDLFHYVNKFG QSK_Spur VMKLLS-----HPHIIRLYQVMETD------------RYMYLVTEYASGGEIFDHLISHG SIK_Spur IMKMLS-----HPNVIKLYQVMETK------------SMLYLVTEYASNGEMFD---THG CG4290_Dmel IMKRLK-----HPHIIKLYQVMETK------------NMIYIVSEYASQGEIFDYIAKYG AqueK068_Aque IMKQLD-----HPHIIKLYQVMNTT------------QWLYLVTEYASGGEIFDYLIQHR AqueK069_Aque ILKQLCEGHFEHDYICRVLDVCIDRSPVLNGSGVVLGRIQFVVFEYCSGSDLFNFLCSGP ::* : * : : :: ::: ::. .:::. SIK_Hsap --------------------HLSENEARKKFWQILSAVEYCHDHHIVHRDLKTENLLLDG QSK_Hsap --------------------RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA QIK_Hsap --------------------RLNESEARRKFWQILSAVDYCHGRKIVHRDLKAENLLLDN CG15072_Dmel --------------------RMKEPEAARVFTQLVSAVHYCHRRGVVHRDLKAENVLLDK kin-29_Cele -------------------GRVAENVARKWFSETASAVAYLHSQGIVHRDLKAENILLGK QIK_Mmus --------------------RLNESEARRKFWQILSAVDYCHGRKVVHRDLKAENLLLDN QSK_Mmus --------------------RMAEKEARRKFKQIVTAVYFCHCRNIVHRDLKAENLLLDA SIK_Mmus --------------------HLSENEARQKFWQILSAVEYCHNHHIVHRDLKTENLLLDS DDB0231454_Ddis LKGVKMVNSPDIGDQVLMGVPLPEDDTKRIFTQICLGIAHCHKLNIAHRDIKHKNILFDN QSK_Spur --------------------KMTEREARQKFKQIVAAVHYCHKRGIVHRDLKAENLLLDA SIK_Spur --------------------RMSEKEAKKKFMQIIAAVEYCHKRHVVHRDLKAENLLLDG CG4290_Dmel --------------------RMSESAARFKFWQIISAVEYCHKKGIVHRDLKAENLLLDL AqueK068_Aque --------------------KMTESEARKKFKQIVMAVDYCHSRGIVHRDLKAENLLLDE AqueK069_Aque WEKH------------RKVSNFSEPLARHYFKQVLLGVMYLHERGMYHRDIKPENCVLDD . * : * : .: . * : ***:* :* ::. SIK_Hsap NMDIKLADFGFGNFYKSGEPLS------TWCGSPPYAAPEVFEGKEYEGPQLDIWSLGVV QSK_Hsap NLNIKIADFGFSNLFTPGQLLK------TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVV QIK_Hsap NMNIKIADFGFGNFFKSGELLA------TWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVV CG15072_Dmel DMNIKLADFGFSNHYEEGATLK------TWCGSPPYAAPEVFQGLEYDGPKSDIWSLGVV kin-29_Cele NSNIKIIDFGFSNFQTGDQLLN------TWCGSPPYAAPELLLGNSYDGMKADIWSMGVL QIK_Mmus NMNIKIADFGFGNFFKTGELLA------TWCGSPPYAAPEVFEGQQYEGPQLDIWSMGVV QSK_Mmus NLNIKIADFGFSNLFTPGQLLK------TWCGSPPYAAPELFEGKEYDGPKVDIWSLGVV SIK_Mmus NMDIKLADFGFGNFYKPGEPLS------TWCGSPPYAAPEVFEGKEYEGPQLDVWSLGVV DDB0231454_Ddis QMNVKIIDFGLSNWSYQE--KM------SFCGTPAYAAPEMLLGINYNGPEVDIWSLGVI QSK_Spur NMNVKIADFGFSNFFEKDHLLK------TWCGSPPYAAPELFEGREYNGPKADVWSLGVV SIK_Spur NMNIKIADFGFSNFFVPGEHLA------TWCGSPPYAAPEVFEGQKYDGPQLDIWSLGVV CG4290_Dmel NMNIKIADFGFSNHFKPGELLA------TWCGSPPYAAPEVFEGKQYTGPEIDIWSLGVV AqueK068_Aque NSNVKLADFGFSNSFKNEELLK------TWCGSPPYAAPELFEGKEYSGPQADIWSLGVV AqueK069_Aque NLNLKLTDFGTNKYFADADPMKLIRTKTRGVGTETYRAPEVNSGLDYDPAAADVWSLGVT : ::*: *** .: *: .* ***: * .* *:**:** SIK_Hsap LYVLVCGSLPFDG-PNLPT-------------------------------LRQRVLEGRF QSK_Hsap LYVLVCGALPFDG-STLQN-------------------------------LRARVLSGKF QIK_Hsap LYVLVCGALPFDG-PTLPI-------------------------------LRQRVLEGRF CG15072_Dmel LYALVCGALPFDG-KTILE-------------------------------LKSRVVLGKF kin-29_Cele LYILVAGGFPFPS-DSVNK-------------------------------LKRSVLSGLV QIK_Mmus LYVLVCGALPFDG-PTLPI-------------------------------LRQRVLEGRF QSK_Mmus LYVLVCGALPFDG-STLQN-------------------------------LRARVLSGKF SIK_Mmus LYVLVCGSLPFDG-PNLPT-------------------------------LRQRVLEGRF DDB0231454_Ddis LYSLVTGKLPFIN-VT-------------------------------------DMIVGKF QSK_Spur LYVLVSGALPFDG-KTLHN-------------------------------LRARVLSGQF SIK_Spur LYVLVCGALPFDA-NTLPQ-------------------------------LKERVLAGKF CG4290_Dmel LYVLVCGALPFDG-STLQS-------------------------------LRDRVLSGRF AqueK068_Aque LYVMVCGALPFDG-NNLQH-------------------------------LRARVLAGRF AqueK069_Aque LFFFVGVEQMFAKVQTLDSYSKQIIAPLGIYFPFPLHCSKLDSYLRREADLRGRGVNGSL *: :* * . : * . SIK_Hsap R---------------IPFFMSQDCESLIRRMLVVDPARRITIAQIRQHRWMRAEP-CLP QSK_Hsap R---------------IPFFMSTECEHLIRHMLVLDPNKRLSMEQICKHKWMKLGD-ADP QIK_Hsap R---------------IPYFMSEDCEHLIRRMLVLDPSKRLTIAQIKEHKWMLIEV-PVQ CG15072_Dmel R---------------IPFFMSQECEQLIRNMLVVEPDRRYTIKQIIKHRWLSEWQ-SEM kin-29_Cele K---------------IPYWVSVECADFIRKMLVLNPGKRYTIQNVLQHRWMHIRD-DVQ QIK_Mmus R---------------IPYFMSEDCEHLIRRMLVLDPSKRLSIAQIKEHKWMLIEV-PVQ QSK_Mmus R---------------IPFFMSTECEHLIRHMLVLDPNKRLSMEQICRHKWMKLGD-ADP SIK_Mmus R---------------IPFFMSQDCETLIRRMLVVDPAKRITIAQIRQHRWMQADP-TLL DDB0231454_Ddis I---------------LPPSIPLDLQDLIKKMLTVDREHRLNIMNVLNHPWLSKDP-ASS QSK_Spur R---------------IPFFMSEGCEDLIRHMLILDASRRYTTDQVLNHRWTKGDG-PDP SIK_Spur R---------------IPFFMSQECEHLIRHMLVINPAKRLSIDQIKNHKWFADCGVPAT CG4290_Dmel R---------------IPFFMSSECEHLIRRMLVLEPTRRYTIDQIKRHRWMCPEL-LEH AqueK068_Aque R---------------IPFYMSEECEKLIRKMLQLDPSKRIPLSKVLEHKWMQATP-TTV AqueK069_Aque KGSALPNESFWSEWECLKVSISPGLRDLLNRIFVLDAGLRITLRDILRHPWVTMED-GMS : :. ::..:: :: * .: .* * SIK_Hsap GP-A----------------CP--AFS-------------A-HSYT--SNLGDYDEQALG QSK_Hsap NF-DR-----------LI--AE--CQQ---------------LKEE--RQVDPLNEDVLL QIK_Hsap RP-V----------------LY--PQE---------------QENE--PSIGEFNEQVLR CG15072_Dmel QE-QERFGDMSPGSGTVSKSAS--TSS-------------L-GSAS--DSPPQLDSVVMT kin-29_Cele KNQAA-----------QL--LEAIPSS-------------S-IEIR--QQSTKLNPTIMM QIK_Mmus RP-I----------------LY--PQE---------------QENE--PSIGEFNEQVLR QSK_Mmus NF-DR-----------LI--AE--CQQ---------------LKEE--RQSDPLNDDVLL SIK_Mmus QQ-D----------------DP--AFD-------------M-QGYT--SNLGDYNEQVLG DDB0231454_Ddis TL-I----------------S---QNLLHSPPVVHQPQPPQHQKIQPTSIIPNFNE---- QSK_Spur VF-DK-----------MF--AE--H-N---------------V-QS--NQEEPVNELILQ SIK_Spur QP-V----------------S-----P-------------V-TEIP--KPIGEFNEQALR CG4290_Dmel V--L----------------IA--KYN-------------L-GAER--QTSVEPSEDILR AqueK068_Aque EG-PS-----------PL--RS--SPL-----------Y-P-QKTA--SGNLLWNEQVLL AqueK069_Aque PDIIK-----------ME--MENRCPS-------------A-IRMS--RDASPLL---VG SIK_Hsap IM---QTLG-VDRQRTVESLQNSS------------------------------------ QSK_Hsap AME---DMG-LDKEQTLQSLRSDA------------------------------------ QIK_Hsap LM---HSLG-IDQQKTIESLQNKS------------------------------------ CG15072_Dmel HML--QLPG-LTADMIAQSVHEQR------------------------------------ kin-29_Cele FM---QQHGKWSEEQIIDAVLGRD------------------------------------ QIK_Mmus LM---HSLG-IDQQKTVESLQNKS------------------------------------ QSK_Mmus AME---DMG-LDKERTLQSLRSDA------------------------------------ SIK_Mmus IM---QALG-IDRQRTIESLQNSS------------------------------------ DDB0231454_Ddis ----------------VETLKNNI------------------------------------ QSK_Spur HMV---SMG-LKTEAIMQSITNQS------------------------------------ SIK_Spur LM---QSLG-IDQQKTIDSLRRDA------------------------------------ CG4290_Dmel IMA--EYVG-IGSDKTRASLKKNT------------------------------------ AqueK068_Aque AIQRLQSSN-FSIEAVKQAVLKKQ------------------------------------ AqueK069_Aque SK---L-LGGVDRVVLRESLSGANKEDIAFPEDSEIWQWSLQIEHLESLQLRISGGDAQE :: SIK_Hsap -------------------------------Y-NHFAAIYYLLLERLKEYRNAQCAR-PG QSK_Hsap -------------------------------Y-DHYSAIYSLLCDRHKRHKTLRLGALP- QIK_Hsap -------------------------------Y-NHFAAIYFLLVERLKSHRSSFPVEQRL CG15072_Dmel -------------------------------F-DNIYAIYNLLHDKLQQRRRENQRLQHH kin-29_Cele -------------------------------FESPIFATYELLADKVKKGTLEGTG-EEF QIK_Mmus -------------------------------Y-NHFAAIYFLLVERLKSHRSSFPVEQRL QSK_Mmus -------------------------------Y-DHYSAIYSLLCDRHKKHKTLRPGALP- SIK_Mmus -------------------------------Y-NHFAAIYYLLLERLKEHRSAQPSSRPT DDB0231454_Ddis -------------------------------L-NNN-------------------NNNN- QSK_Spur -------------------------------Y-DENSAIYHLLLDKHRRHLKAAEESQSA SIK_Spur -------------------------------Y-DHYTAIYYLLVERLRLHRCSFPVEGRV CG4290_Dmel -------------------------------Y-DHVAAIYLLLQDRVSHKKEQSNGLGAS AqueK068_Aque -------------------------------Y-NDQAALYYMLLHKWEKGQLQIPLNPLV AqueK069_Aque VMMDLNITLELVRNVLKEPANERHRQVMVDHISNEWIAQLFLIVGFLPKDNSLVLLDEYL . SIK_Hsap PAR--QP----------------------------------------------------- QSK_Hsap SM-PRAL--AF----------QA-----------------------------------PV QIK_Hsap DGRQRRP----------------------------------------------------- CG15072_Dmel ASLAYS------------------------------------------------------ kin-29_Cele PRRGSR------------------------------------------------------ QIK_Mmus DGRQRRP----------------------------------------------------- QSK_Mmus SM-PQAM--TF----------QA-----------------------------------PV SIK_Mmus PAPTRQP----------------------------------------------------- DDB0231454_Ddis --NNN------------------------------------------------------- QSK_Spur AA-LYAL--AL----------GE------------------------------------- SIK_Spur DVRSRRP----------------------------------------------------- CG4290_Dmel -ALASST--SASRMIYSSRNDHQ-----------------------------------PT AqueK068_Aque SQ----L--SY----------QG------------------------------------- AqueK069_Aque DLNLLNCAVSY----------LQGIELAVTRAAIYTQCTDDGNSEGFEEDMEMEAGVMPL SIK_Hsap ----RPRSSDLSG----------------------------L-EVP-------------Q QSK_Hsap NIQ-AEQAGTAMN----------------------------I-SVP-------------Q QIK_Hsap --------STIAE----------------------------Q-TVA-KAQ---------T CG15072_Dmel ----RSRKTSITT----------------------------G-VVD-RSE---------- kin-29_Cele -------GSILSG----------------------------K-ANV-DEQ---------P QIK_Mmus --------STIAE----------------------------Q-TVA-KAQ---------T QSK_Mmus NLQ-AEQTGTAMN----------------------------L-SVP-------------Q SIK_Mmus ----QLRSSDLSS----------------------------L-EVP-------------Q DDB0231454_Ddis ---------NN------------------------------------------------- QSK_Spur GVA-AQRNLMLGD----------------------------Q-MIP-------------Q SIK_Spur --------SSIAD----------------------------H-AIM-RTH---------- CG4290_Dmel QQQSQQQSKTIST----------------------------S-SILAKDQCHKRLSRHQT AqueK068_Aque ----RYSTSSLAS----------------------------FSGVP-------------R AqueK069_Aque EEEEEEEITTFRDSVTLRGESVTEYDTSSSQSFFNNPISTTA-TAS-GSD---------P SIK_Hsap -------------------------------EGLSTD----------------------- QSK_Hsap ------------------------------------------VQ---------------- QIK_Hsap -------------------------------VGLPVTMHSPNMR---------------- CG15072_Dmel ----------------------------------PVKQESL------------------- kin-29_Cele -------------------------------LTPTISAHQ-------------------- QIK_Mmus -------------------------------VGLPVTLHPPNVR---------------- QSK_Mmus ------------------------------------------VQ---------------- SIK_Mmus -------------------------------EILPCD----------------------- DDB0231454_Ddis ------------------------------------------------------------ QSK_Spur ------------------------------------------VN---------------- SIK_Spur -------------------------------AGTLTNIN-PHQR---------------- CG4290_Dmel VLMSERNAHAGATPTVPDPGPGYYAKYGPLQLPLPLTGHSHLTGYLNGGGVEVDASGIPL AqueK068_Aque ------------------------------------------IN---------------- AqueK069_Aque -------------------------------LTIPISMHQ-------------------- SIK_Hsap P--FRPA--LLCPQPQ-------------------------------------------- QSK_Hsap L----------------------------------------------------------- QIK_Hsap L--LRSA--L-LPQAS-------------------------------------------- CG15072_Dmel -DRLSPL--------SNANASSSALG---------------------------------- kin-29_Cele ------------------------------------------------------------ QIK_Mmus L--MRST--L-LPQAS-------------------------------------------- QSK_Mmus L----------------------------------------------------------- SIK_Mmus P--FRPS--LLCPQPQ-------------------------------------------- DDB0231454_Ddis ---NNNN--ILN------------------------------------------------ QSK_Spur V----------------------------------------------------------- SIK_Spur NTNARNA--IQVQQQPCVNTSQQMLGFR-------------------------------- CG4290_Dmel PMRYTPLPTAASPAPSNCSSTSSRVGRHSLSSSSPRSHRPVAISLSIDNNPSLANLRCRE AqueK068_Aque I----------------------------------------------------------- AqueK069_Aque ------------------------------------------------------------ SIK_Hsap -------------TLVQSVLQ----------------AEMDCE--LQSS----------- QSK_Hsap ------------------------------------------------------------ QIK_Hsap -------------NVEAFSF-----------------PASGCQ--AEAA----------- CG15072_Dmel -----------------FG-W------------------SDVA--VDL----------EK kin-29_Cele --------------LAQLNL-----------------SSPDCD--SDDS----------- QIK_Mmus -------------NVEAFSF-----------------PTSSCQ--AEAA----------- QSK_Mmus ------------------------------------------------------------ SIK_Mmus -------------ALAQSVLQ----------------AEIDCD--LHSS----------- DDB0231454_Ddis ------------------------------------------------------------ QSK_Spur ------------------------------------------------------------ SIK_Spur -------PIQPVQQPTQQIVS----------------ESAQCA--LQRKRKEPPLQPSTC CG4290_Dmel MMEAGGGPVGAVG----VP-LASKQLHQTISEFIIKQSTEDCRALLQQ----------ST AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque --------------FYNRSI-----------------SSNE------DN----------- SIK_Hsap -LQ------------WPLFFPVDASCSGVFRPR--------PVSPSS------------- QSK_Hsap ------------------INPENQ--IVEPDGT--------------------------- QIK_Hsap -FMEEECVDTP-KVNGCLLDPVPP--VLVRKGC--------QSLPSN------------- CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ----------------------------------------------S------------- QIK_Mmus -FMEEECVDTP-KVNGCLLDPVPP--VLVRKGC--------QSLPSS------------- QSK_Mmus ------------------INPENQ--IIEPDGA--------------------------- SIK_Mmus -LQ-------------PLLFPLDTNCSGVFRHR--------SISPSS------------- DDB0231454_Ddis ------------------------------------------------------------ QSK_Spur ------------------TNEDNQ--VIQSNDQ--------------------------- SIK_Spur IFSEGEMVPVPPAVSGTLLEPLPR--MNVRKVR--------SMSPNH------------- CG4290_Dmel AVAEGK-DDP-PKAESSV-GGVPP--PA-------------STTPTSSTAGPESGSAPCP AqueK068_Aque ------------------DG---------------------------------------- AqueK069_Aque -M-----------------------------SQGLCLLFFICTCMYC------------- SIK_Hsap ------------------------------------------------------------ QSK_Hsap ------------------------------------------------------------ QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus ------------------------------------------------------------ SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis ------------------------------------------------------------ QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel GEINGKTIKTMSSSSSFDSKANLGQSFRYKMSAEASKLFQTLQESPLPVEQRTKRRVHVG AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque ------------------------------------------------------------ SIK_Hsap ------------------------------LLDTAIS--EEAR-QG-PGL----EEEQDT QSK_Hsap ----------------------------------------LN-LDSDEGE----EPSPEA QIK_Hsap ------------------------------MMETSID--EGLETEG-EAE----EDPAHA CG15072_Dmel ----------------------------------YGD--FELECLA-RS-----NDPPVN kin-29_Cele ------------------------------NSDLCDD-SPMS-SMG-PMNHERQFGTPHG QIK_Mmus ------------------------------MMETSID--EGLETEG-EAE----EDPSQA QSK_Mmus ----------------------------------------VN-LDSDEGE----EPSPEA SIK_Mmus ------------------------------LLDTAIS--EEAR-QG-PSL----EEEQEV DDB0231454_Ddis ------------------------------------------------------------ QSK_Spur ----------------------------------------LEEMDS-DPE----EPSPEA SIK_Spur ------------------------------MVVTSID--EGVEADL-PES----ENEMEK CG4290_Dmel STNGSGGDSGQETNDAKSNGDSRSEKKVLAQGSSSTD--EGCETDQ-G------NDPGSA AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque ------------------------------IIETAIASSQES-MWA-PGSVSTQ-SSQ-- SIK_Hsap QESLP---------------------------S--STG-----------RRHTLAEVSTR QSK_Hsap LV-------------------------------RYLSM-----------RRHTVGVADPR QIK_Hsap FEAFQ---------------------------STRSGQ-----------RRHTLSEVTNQ CG15072_Dmel AQHLSAHAGGG---------------------VNGANT-----------RRHTVGPGD-- kin-29_Cele LDII----------------------------GNRFEN-----------RRHTLCASEQL QIK_Mmus FEAFQ---------------------------ATRSGQ-----------RRHTLSEVTNQ QSK_Mmus LV-------------------------------RYLSM-----------RRHTVGVADPR SIK_Mmus QEPLP---------------------------G--STG-----------RRHTLAEVSTH DDB0231454_Ddis ---------------------------------SNNNN-----------NNNNNNNSNNN QSK_Spur LA-------------------------------RYLQI-----------RRNTVIPGDPS SIK_Spur VGSME---------------------------H-FKSQ-----------RTHSLAESYDI CG4290_Dmel SQESKGSNGGGSGNANGGPTSHSSSDLTRLVGTTTSGQSH---------KMRSYASSSSS AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque -DDL-----------------------------PDGYQ-LVHEWNVDFSPWHRLIELSST SIK_Hsap LS-PLT-APCIVVSPSTTASPAEGTSSDS-CLTF-SASKSPAGLSGT--PATQGLL---- QSK_Hsap TE-VME-DLQKL-------LPGFPG-VNP-QAPFLQVAPNVNFMHNL--LPMQNLQPTGQ QIK_Hsap LV-VMP-GAGKIFSMN--DSPSLDS-VDS-EYDMGSVQRDLNFLEDN--PSLKDIM---- CG15072_Dmel ---------VAHEQAL--ANPNVPP-IDF-KCP-------------------PQ------ kin-29_Cele LS-PN------------------------------------------------------- QIK_Mmus LV-VMP-GAGKMFSMS--DNPSLES-VDS-EYDMGSAQRDLNFLEDS--PSLKDIM---- QSK_Mmus TE-VME-DLQKL-------LPGFPG-VNP-QGPFLQVAPNMNFTHNL--LPMQSLQPTGQ SIK_Mmus FS-PLN-PPCIIVSSSATASPSEGTSSDS-CLPF-SASEGPAGLGSG--LATPGLL---- DDB0231454_Ddis NI-INNSNN---------NSNNNNN-INNNINNNNNVNNNVNNNKNN--NNN-------- QSK_Spur GHKVPA-ALRAK-------LPAPPQ-LAG-MGLGGPCISDLTLLNNA--FN--------- SIK_Spur QT-SMA-PSLSDFGIE--PQELSAS-FDS-QEEMEVA-QSFAHV-----QALSD------ CG4290_Dmel SG-VLA-GSAGSYSKS--LSQNLSR-GSS-KSNCSGPYDSLDFALPSGKGSLPSCM---- AqueK068_Aque --------------------------VGS-SSGSMGIVPWQNF------------HG--- AqueK069_Aque LQ-IH------------------------------------------------------- SIK_Hsap -------GACSP------------------------------------------------ QSK_Hsap LEYKEQSLLQPPTLQLL------NGMGPLGRRASDGGANIQLHAQQLLKR---------- QIK_Hsap -------LANQPS----------------------------------------------- CG15072_Dmel --CS---DPTQPVPYYPVNLPMLQNQ----------------------PLH--------- kin-29_Cele ------------------------------------------------------------ QIK_Mmus -------LANQPS----------------------------------------------- QSK_Mmus LEYKEQSLLQPPTLQLL------NGMGPLGRRASDGGANIQLHAQQLLKR---------- SIK_Mmus -------GTSSP------------------------------------------------ DDB0231454_Ddis ---NNNNSN----------------------NNSNNGNN----------I---------- QSK_Spur --LQEQNLLKPPVLEAT------AGQSSFGRRASDGGANMYLNIQQFRKQ---------- SIK_Spur --------RLFP------------------------------------------------ CG4290_Dmel --GSSS-MLATPTPASA-SPAGISSE----------------------HSSERSLYGSHN AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque ------------------------------------------------------------ SIK_Hsap ----------VRLASPFLGSQSA-TPV--------------------------------- QSK_Hsap ----------PRGPSPLVTMTPA-VPAVTPVD-EESSDGEPDQEAVQRYLANRSKRHTLA QIK_Hsap ----------PRMTSPFISLRPT-NPA--------------------------------- CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus ----------PRMTSPFISLRPA-NPA--------------------------------- QSK_Mmus ----------PRGPSPLVTMTPA-VPAVTPVD-EESSDGEPDQEAVQRYLANRSKRHTLA SIK_Mmus ----------VRLASPFLGSQSA-TPV--------------------------------- DDB0231454_Ddis ----------PNSSNNT------------------------------------------- QSK_Spur ----------LQ--TTVRTSQPGDIDATGQVQEDENSDGEPDEEAIRRYLDKGRCRHTIG SIK_Spur ----------SNCNSPDLTQQQT-EPM--------------------------------- CG4290_Dmel SCIHMPGALPLGLGLPQSSASTP-TP---------------------------------- AqueK068_Aque -----------------PS-------LAPPTM-NNASDSTMDA-NLQRY-LNQGRRHTLG AqueK069_Aque ------------------------------------------------------------ SIK_Hsap ------------------------------------------------------------ QSK_Hsap MTNPTAEIPPDLQRQLGQ---QPFRSR----------------VWPPHLVPDQHRST--- QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus MTSPTAEIPPDLQRQLGQ---QSFRSR----------------VWPPHLVPDQHRST--- SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis ----NSIINNNLY----------------------------------------------- QSK_Spur PDVLTNNDMPLVSR-------------------------------------PRHNRF--- SIK_Spur -----------------------------------IP-----------------PP--AP CG4290_Dmel ------------------------------------------------------NP--TP AqueK068_Aque TAHNMLIIPPEDMNRLRKINESSSSQASSGFGSSSTNVPPVHPEMQPHIIPTLSTGIEE- AqueK069_Aque ----------------------------------------------------------E- SIK_Hsap -----LQAQGGLGGA--VLLP-VS---FQEGRRASDTSLTQGLKAFR-QQL--------- QSK_Hsap ----------YKDSNT-LHLPTER---FSPVRRFSDGAA--SIQAFK-AHL--------- QIK_Hsap -----MQALSSQKREVHNRSP-VS---FREGRRASDTSLTQGIVAFR-QHL--------- CG15072_Dmel -------NLT-IKDQHLLKPP-VVMGASSFGRRASDGGANLHIY---------------- kin-29_Cele ------------------------------------------------------------ QIK_Mmus -----MQALSSQKREAHNRSP-VS---FREGRRASDTSLTQGIVAFR-QHL--------- QSK_Mmus ----------YKDSNT-LHLPTER---FSPVRRFSDGAA--SIQAFK-AHL--------- SIK_Mmus -----LQTQAGLGTA--VLPP-VS---FQEGRRASDTSLTQGLKAFR-QQL--------- DDB0231454_Ddis -----NQSLSPQNNNIYQHSP-QHQ---QHQHQQQHSPQ--------------------- QSK_Spur ----------LQPERS-LHLFAS-----TNARRASDGMP--NLQYYQRERL--------- SIK_Spur P-QAMFQHSASLDR-SGSHSP-VS---FREGRRASDGLIAQTGLSYR-QVSPTPLAQ--- CG4290_Dmel ------PPNGGGVTFLDKRSP-IH---FREGRRASDGLVAQGLLSSG-SLLGTSRVYGSY AqueK068_Aque PKTSIG-SIVSSSRQF-LQLP-RF---FSSKRRASDGGH--YLEAYR-QFL--------- AqueK069_Aque PKQYRAA----------------------------------------A-EF--------- SIK_Hsap -RKTT---------RTKG-----------------FLGLNK-IKGLARQV-CQ------- QSK_Hsap -EKMG---------NNS-----------------SIKQLQQECEQLQKMY-GGQ-I---- QIK_Hsap -QNLA---------RTKG-----------------ILELNK-VQLLYEQI-GPE-A---- CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus -QNLA---------RTKG-----------------ILELNK-VQLLYEQM-GSN-A---- QSK_Mmus -EKMG---------NSS-----------------SIKQLQQECEQLQKMY-GGQ-V---- SIK_Mmus -RKNA---------RTKG-----------------FLGLNK-IKGLARQV-CQ------- DDB0231454_Ddis ---QQ---------QHQ-----------------QHQHHQQQQQQLQQQH-HQQ-H---- QSK_Spur -ERLAATGGGSSSSQKS-----------------SLKQLHKECQQLQKQF-SSP-I---- SIK_Spur GHKDA---------SLDGHLKT-------------NLNMNS-CSLAADQL---------- CG4290_Dmel RYEQA---------KRHG-----------------WLEIQQ-LQQLQQEA-AVGHSHPHA AqueK068_Aque -HKRS---------STMYSHQASVEGGVVSAQPTTAKQLLQEKIETDRLY-GR--L---- AqueK069_Aque -CK---------MS----------------GLLCSYGLYQVVCHDQLAMYCRGN-I---- SIK_Hsap ---------------------------APA-----S--RASRG------G-L-------- QSK_Hsap ------DERTLEKTQQQHMLYQQEQH-HQILQQQIQD------SICP-PQ-PSPPLQAAC QIK_Hsap ------DPNLAPAAPQLQDLASSCPQ-EEVSQQQES-VSTLPA------S-V-------- CG15072_Dmel ------------------------------------------------------------ kin-29_Cele -------------------------------------------MMGQ-FP---------- QIK_Mmus ------DPTLTSTAPQLQDLSSSCPQ-EEISQQQES-VSSLSA------S-M-------- QSK_Mmus ------DERTLEKTQQQHMLYQQEQH-HQILQQQIQD------SICP-PQ-PSPPLQVAC SIK_Mmus ---------------------------SSV--------RTPRG------G-M-------- DDB0231454_Ddis ------HQQ-HQQHQQQHQQQHQQQ-HQ-QHQQHQQS------HQQP-PV--YFPTQIIS QSK_Spur ------DARA-------------------------------------------------- SIK_Spur -----------------QIVGFSGQQLTEVSKDNAD-LTNLPS------CQV-------- CG4290_Dmel HQHPHQHPHPHPQAYGLEELC----Q-FP----NGQ-FYALPG------K-H-------- AqueK068_Aque ------PRQKLP--HNPHLLSSSGLESSNIIAQMVQPVQPLTSSTLPLPV-PMANLREQC AqueK069_Aque ------ASFSMR------------------IVNQIVD------GLCK-VF-ISTWC--MC SIK_Hsap ------------------------------------------------------------ QSK_Hsap ENQPALLTHQLQRLR----IQPSSPPPNHPNNHLFRQPSN--SPP-PMSSAMIQPHGAAS QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele -------------------------PPNLLLNNFSMNPPLGF--P-PMPEG---QAAEFP QIK_Mmus ------------------------------------------------------------ QSK_Mmus ENQPALLTHQLQRLR----IQPSSPPPNHPSNHLFRQPSN--SPP-PVSSAMITSHGATS SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis DD--FNLTSQLQRT------QPNQQV-SFDTNQSYQQQLQ--QPQIP------------- QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque QPFH-DITQQQIREQ----LEQLHMSNGSPSDH------G--SLP-HAQSSGVASGGSST AqueK069_Aque GNDEWALV--LERLTLADRIDAF--QRCLA---DTDLPSINTSKP-TCSDHLLEIVAEYD SIK_Hsap ------------------------------------------------------------ QSK_Hsap SSQFQGLPSRSAI---FQQQPENCSS--PPNVALTCLGMQQPAQSQQVTIQVQEPVDMLS QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele LP-SLHPA--------FATI----------------------------------PIADLS QIK_Mmus ------------------------------------------------------------ QSK_Mmus PSQFQGLPSHGAI---FQQQPENCSP--PPSVALTCLGLQQASQSQPVTIQLQEPVDMLS SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis ---------HQVL---MQQPPQILSHSNNQPINNYYVGQQ-------------------- QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque ----------SSI---N--SRKNSSG--NNSIIAQLLAATPPSASPSFPTQMVA-TSMAS AqueK069_Aque SKSPCGQLKRFAAYIELHDV----------------------------------PYEELS SIK_Hsap ------------------------------------------------------------ QSK_Hsap NMPGTAAGSSGRGISISP-----------------------------------SAGQMQM QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele K----------------------------------------------MLPVPK------- QIK_Mmus ------------------------------------------------------------ QSK_Mmus NMAGTAAGSAGRSIPISP-----------------------------------SASQIQI SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis ------------------------------------------------------------ QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque SEYDGASTSNERRYSIQP-----------------------------------SP----- AqueK069_Aque SLTLSPAGDGDGGDEDSQSTLKEIAYHCYYDIDDRLCSDYNFCIDSSSLPVLYTRDA-CL SIK_Hsap ------------------------------------------------------------ QSK_Hsap QHRTNLMATLSYGHRPLSKQLSADSAEAHSLNVNRFSPANYDQAHLHPH----------- QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele -------------------------SERRASAGETLLPTNFDLTQH-------------- QIK_Mmus ------------------------------------------------------------ QSK_Mmus QHRASLMAPFSYGHRPLSKQLSADSAEAHSLNMNRFSPANYDQAHLHPH----------- SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis ------------------------------------------------------------ QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque --HSSLNPPVTRHHRKTLPDL-------HPQLIIVE-----PPANLHPQ----------- AqueK069_Aque MESSVLIAGESFNEKIYTYQMAV-AVIIESNYADKYNPAI-TQHYMHTCMEHYNDIEICL SIK_Hsap ------------------------------------------------------------ QSK_Hsap ------LF--------------------------------------------------SD QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus ------LF--------------------------------------------------SD SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis ------------------------------------------------------------ QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque ------AS--------------------------------------------------TS AqueK069_Aque FEIFHHCFTLEDVYYYTPYWCYYDVLTMMCSQFKGDEQLLCEVVLEARWELSLVSECTNE SIK_Hsap -------------------------------SPFHA-PAQ-------------------- QSK_Hsap QSRGSPSSYSPSTG-VGFSPT-QALKVPPLDQFPTF-PPSAHQ-QPPHYTTSALQQALLS QIK_Hsap -------------------------------HPQLS-PRQ--SLE-TQYLQHRL------ CG15072_Dmel ----------------------------------------------------------YP kin-29_Cele --------------------L-ANLPAPPI-SFPTV-EEEGKS-YLSKY----------- QIK_Mmus -------------------------------HPQLS-PQQ--SLE-TQYLQHRL------ QSK_Mmus QSRGSPSSYSPSTG-VGFPPT-QALKVPPLDQFPTF-PPSAQQ-QPPHYTTSALQQALLS SIK_Mmus -------------------------------STFHT-PAP-------------------- DDB0231454_Ddis -------------------PI-QQIQ--QLQQQQQL-QQQQQQ-QQQQ------QQQ--- QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------E--QELVSWRRF-PAQVQSMERRQYRMHAMKQGVHT CG4290_Dmel -------------------------------HPLLTLPHHHAHPAQHHHGHHSLFHSGHQ AqueK068_Aque SSLGES---SPESS-LGATANAIGRRSPPYFQV--G-SPGEVG-SPLHWQERQRKTGM-S AqueK069_Aque NNKGKC--EDIITGIVDTKPI-SQINSSDIDQMKAV--LSANS-RQLNYTNETLTQ--LS SIK_Hsap -S-------------------------------------P----GLHG------------ QSK_Hsap PTPP---------DYTRHQ-------------Q-----VPHILQGLLSPRHSLTG----- QIK_Hsap QK-------------------------------------P----SLLSKAQ--------- CG15072_Dmel ATGTVVGPAQGQQMDTAGY-------------YINPNCG--------------------- kin-29_Cele ---------------------------------------------------------GGK QIK_Mmus QK-------------------------------------P----NLLPKAQ--------- QSK_Mmus PTPP---------DYPRHQ-------------Q-----VPHILQGLLSPRHSLTG----- SIK_Mmus -S-------------------------------------S----GLQG------------ DDB0231454_Ddis ----------------QQ------------------------------------------ QSK_Spur ------------------------------------------------------------ SIK_Spur EP-------------------------------------P----GHLTHSASLAG----- CG4290_Dmel ATPLLLEAAAGGDMYGHGC-------------YAPPPPPP----GLYTHHQLGVG----- AqueK068_Aque LQPS------------------------------------------------HLG----- AqueK069_Aque RIVE---------YFSLNQSAVSMIIDKQDANT-----FLSVISGLASEN---GTRSLME SIK_Hsap ----------------------------GAA------------------GSREGWSL--L QSK_Hsap -------------------HS-----D-IRL-----------PPTEFAQ----------L QIK_Hsap --------------------N-----T-CQL------------------YCKEPPRS--L CG15072_Dmel --------------------------T-DPL-----------AVQE--------LSP--L kin-29_Cele RNTVHCLGNQLGGGIQNPI-PRYQRTPYTKA-----------PPAE----RRSSWASPSL QIK_Mmus --------------------S-----P-CPV------------------YCKEPPRS--L QSK_Mmus -------------------HS-----D-IRL-----------PPAEFAQ----------L SIK_Mmus ----------------------------CTT------------------SNREGRSL--L DDB0231454_Ddis ---------------------------------------------QQQQ----------Q QSK_Spur ------------------------------------------------------------ SIK_Spur -------------------QS-----S-LED-----------MPREFPNQMPPNPHT--L CG4290_Dmel -------------------M------A-VPM-----------SPMQ--------KPP--L AqueK068_Aque -------------------AS-----S-IEDDFCKGVTIPNLPDP-QSS----------I AqueK069_Aque SSSVKLKLNKTDTNS-SNMTA-----S-ILI-----------PPAS----IC------NS SIK_Hsap -EEVL-EQQ--------------------------------RL-----LQLQ--HHP--- QSK_Hsap -IKRQ-QQQ--------------------------------R---Q-QQQQQ--QQQQEY QIK_Hsap -EQQL-QEH--------------------------------RL-QQKRLFLQ--KQSQLQ CG15072_Dmel NEQSV-AQM--------------------------------Q-CCQENATGE--CNEELQ kin-29_Cele -SAQQ-QNHLE------------------------------KLFKQALQTNN--DMTR-L QIK_Mmus -EQQL-QEH--------------------------------RL-QQKRLFLQ--KQSQLQ QSK_Mmus -IKRQ-QQH--------------------------------R---Q-QQQQQ--QQQQEY SIK_Mmus -EEVL-HQQ--------------------------------RL-----LQLQ--HHSSTA DDB0231454_Ddis -QQQQ-QQQ--------------------------------Q---QQQQQQQ--QQQQ-Q QSK_Spur ------------------------------------------------------------ SIK_Spur -QRTL-LHQ--------------------------------RL-MQKRQQLQ--KQSQLS CG4290_Dmel -QQQL-LQH--------------------------------RLLQQKRQLFQ--KQYALE AqueK068_Aque --VPQ-PLQ--------------------------------Q---Q-QQQHD--ILQQSV AqueK069_Aque -DTVDDYGLEEEEEYDGSGEDYYYYYYDELCPKGVLNCTQDINGYEYVYYNLYELFGD-C SIK_Hsap AAAP---------------GCSQA------------------------------------ QSK_Hsap QELFRHMNQGDAGSLAPSLGGQSM----------TER--QALSY-----QNADSYH---H QIK_Hsap -AYF---------------NQMQI----------AES--------------S-YP--Q-- CG15072_Dmel -SYM---------------QKRGG----------T-Q--R-----------H-T------ kin-29_Cele HKEFKGLSHGCAQSQITNEGSSLA----------CPQIS--IT---------DEYNRQ-H QIK_Mmus -AYF---------------NQMQI----------AES--------------S-YP--G-- QSK_Mmus HELFRHMNQGDAVSLAPSLGGQNM----------TEQ--QALSY-----QNADSYH-R-H SIK_Mmus AASS---------------GCQQG------------------------------------ DDB0231454_Ddis QQQQQQQQQQNDPNFQPHLRRIKM----------SKR--D-NSYNKRKSEDGDSYK-KRD QSK_Spur ------------------------------------------------------------ SIK_Spur -QQF---------------GCMQL----------ERQ--------------S-SF--E-- CG4290_Dmel -AQL---------------AGRHH----------HHQ--Q-----------H-SH--H-H AqueK068_Aque QQIPIFFNQH-ISLLNPNVANQ-------------------IAH-----QQMSSL--V-H AqueK069_Aque S-RKLKVPRSCPVVITTSIADSVSSLLSASLPENMTIASLVLSS-----Q--IVTRSE-- SIK_Hsap ------------------------------------PQ-PAPAPF-V--IAP-------- QSK_Hsap HTSP-------QHLLQIRA------QECVSQA----SS-PTPPHGYA--HQPALMHSESM QIK_Hsap ----------------------------PSQQLPLPRQ-ETPPPS-Q--QAP-------- CG15072_Dmel ------------------------------------------------------------ kin-29_Cele NIAPSASSFDPVSIFQKNA------QEVVF-G----QR-PATAIGFS--STS-------- QIK_Mmus ----------------------------PSQQLALPHQ-ETPLTS-Q--QPP-------- QSK_Mmus HTSP-------QHILQIRA------QDCISQG----PS-PTPTHGYA--HQPPLMHSESM SIK_Mmus ------------------------------------PQ-LSPVPY-V--LAP-------- DDB0231454_Ddis NQSY-------DDILKDEGNKRLRELQTYSEG----DK--------SRQHYNRDSNDNSR QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel H-----------------H------HFGHSLG----PP-PPPAP------AP-------- AqueK068_Aque HIS--------------------------------------------------------- AqueK069_Aque --------NNSTNVTQSLR------ENAML-Q----FKLLMPMNLTE--FVPKCYYWDTL SIK_Hsap -------------------------CDGP------------------------------- QSK_Hsap --------------------EEDCSCEGAKDGF-------Q------------------- QIK_Hsap -------------------------PF--------------------------------- CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus -------------------------SF--------------------------------- QSK_Mmus --------------------EEDCLCEGLKEGF-------P------------------- SIK_Mmus -------------------------CD--------------------------------- DDB0231454_Ddis DNNRYNNRDNNNNNNSNNNRERDRYKKNKNENFDYGKYKFGKSNEDEENKDKPNIVREKP QSK_Spur ------------------------------------------------------------ SIK_Spur ---------------------------G-------------------------------- CG4290_Dmel -------------------------EH--------------------------------- AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque --------------------ENVWSDDG-------------------------------- SIK_Hsap ----------GAAPLPS------------------------------------------- QSK_Hsap DSKSSSTLTKGCHDSP-------------------------------------------- QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele --------FSGM-STPEQTTRS---------------------------------IDDRV QIK_Mmus ------------------------------------------------------------ QSK_Mmus D-KSSSTLTKGCHNSP-------------------------------------------- SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis DFKPSGSLKN-------------------------------------------------- QSK_Spur ------------------------------------------------------------ SIK_Spur -----------RPPAPN------------------------------------------- CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque NVLSSFKIVYQCSGNV-------------------------------------------- AqueK069_Aque --------IETL-VLSDQDVLCNTSHLTSFAVLVDHQGLIESTNIPSAERKALSIVGYIG SIK_Hsap ---TLLT-------SGLPLLP----------PPLL---QT-------------------- QSK_Hsap ---LLLS-------TGGPGDP----------ESLL---GT-------------------- QIK_Hsap ---SLTQ-------PLSPVLE----------PSSE---QM-------------------- CG15072_Dmel ------------------------------------------------------------ kin-29_Cele RSIVCTL-------PFTEVIDELKASLNILKIPFSESHEM-------------------- QIK_Mmus ---SLTQ-------ALSPVLE----------PSSE---QM-------------------- QSK_Mmus ---LLLC-------TSGPGDP----------EPLL---GT-------------------- SIK_Mmus ---SLLV-------SGIPLLP----------TPLL---QA-------------------- DDB0231454_Ddis -------------------DS----------SSNY---GT-------------------- QSK_Spur ------------------------------------------------------------ SIK_Spur -------------------RT----------DSYK---QA-------------------- CG4290_Dmel ---HLADELYELALLDRPRSG----------TPRL---Q--------------------- AqueK068_Aque ---FTIC----------------------------------------------------- AqueK069_Aque PGFSLLC-------LI----------IALVIMIALRKRMNTSFLYWIHLNLCISLLLALT SIK_Hsap ------------------------------------------------------------ QSK_Hsap ------------------------------------------------------------ QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus ------------------------------------------------------------ SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis ------------------------------------------------------------ QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque VLLVGLETAHHYNWLCSIVAGLLHYLFLCVFAWMLAEGITLFIMVVYVFGIKFLKWQIFI SIK_Hsap ------------------------------------------------------------ QSK_Hsap ------------------------------------------------------------ QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus ------------------------------------------------------------ SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis ------------------------------------------------------------ QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque PTAWGIPLFIVAISAGIRHDLYGTDNYCWLSSQKGLVWAFLGPALTVAVVNTIFLVITMI SIK_Hsap ------------------------------------------------------------ QSK_Hsap ------------------------------------------------------------ QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus ------------------------------------------------------------ SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis ------------------------------------------------------------ QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque QIVRVTWNKLDNNKMSKSKNLQTAKSAIFGAIVLFPLLGITWIIGVFAVSQNTTVFLWLF SIK_Hsap -----------------GASPVASAAQLLD----------------------THLHIG-- QSK_Hsap -----------------V-----SHAQE----------------------LGIHPY---- QIK_Hsap -----------------QYSPFLSQYQEMQ---LQPLPSTS--GPRAAPPLPTQLQQQQ- CG15072_Dmel ------------------------------------------------------VGCT-- kin-29_Cele -----------------VYEPQVTE---MR---RLSLPSGVEIGVAVLP----------- QIK_Mmus -----------------QFSSFLSQYPEMQ---LQPLPSTP--GPQAPPPLPSQLQQHQQ QSK_Mmus -----------------V-----SQARE----------------------LGIHPY---- SIK_Mmus -----------------GMSPVASAAHLLD----------------------THLHIS-- DDB0231454_Ddis -----------------I-----SSGRN-------------------------------- QSK_Spur --------------------------QE----------------------LQM------- SIK_Spur -----------------QQHPVLPQYAIN------------------------------- CG4290_Dmel ------------------HSMTMPGAHAFSQMNLKT----------------SYISQS-- AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque TICNSLQGVFILIFHVFKHRAFLT------------LIAR-KCPCMDRF----------- SIK_Hsap -------------------------------------------T---------------G QSK_Hsap -------------GHQPTAA-----FS--K-------N--KVPSREPVIGNCMDRSSPGQ QIK_Hsap PPPPPPPPPPRQPGAAPAPLQ----FSYQT-------C--ELPS---------------A CG15072_Dmel ---------E-------DLSVAHGSGAGSQ-------S--QAP----------------- kin-29_Cele ------------------------------------------------------------ QIK_Mmus PPPPPPPPPPQQPGAAPTSLQ----FSYQT-------C--ELPS---------------T QSK_Mmus -------------GHQPTATT----FS--R-------N--KVPSRESVLGNCLERSSPGQ SIK_Mmus -------------------------------------------A---------------G DDB0231454_Ddis --------------------------N--NNGEEDEEN--KIK---------LKWHEPAE QSK_Spur ------------------------------------------------------------ SIK_Spur ---------------DDSSLN----KSLIQ-------CHNEFNQ---------------A CG4290_Dmel ---------DQVPGAAPNGAGSGGSAAGVS-------C--SAP----------------- AqueK068_Aque ------------------------------------------------------------ AqueK069_Aque ------------------------------------------------------------ SIK_Hsap PTALPAVP------------------------PPRL---AR------------------- QSK_Hsap AVELPDHN-GLGYPARP-SVHEHHRPRAL-QRHHTI---QN------------------- QIK_Hsap ASPAPDYPTPCQYPVDG-AQQSDLTGPDC-PRSPGL---QE------------------- CG15072_Dmel -TTS----------------------SNMR------------------------------ kin-29_Cele ---------PEHKAH----VEFAIINNDS-PTS--------------------------- QIK_Mmus TSSVPNYPASCHYPVDG-AQQSNLTGADC-PRSSGL---QD------------------- QSK_Mmus AMELPDHN-GLGYPVRP-LVSEHLRSRTL-QRHHTI---QN------------------- SIK_Mmus PVALPTGPL-----------------------PQCL---TR------------------- DDB0231454_Ddis A-KLPTE-KWMLYPFKG-KDQLD--TIYL-HRKKSFLFGRNRDIADIPIDHPSCSSQHAV QSK_Spur ------------------------------------------------------------ SIK_Spur TSLGSNAP--LHYDTTL---------NQV-PQ-------NF------------------- CG4290_Dmel PSTAPGTPTVKCKPTTPHGHS--LD-SDYHTSTPVL---SL------------------- AqueK068_Aque ------HR-GVDFQIHV-QVS----------PHYAI---QN------------------- AqueK069_Aque --------INVHSSVEA-SRKRSTFRYDN-SRK------KS------------------- SIK_Hsap --------LAPGCEPLGLL--------------------QGDCEMEDL------------ QSK_Hsap --------SDDAY--VQLDNLPGMS--------LVAGKALSSARMSDAVLSQSSLMGSQQ QIK_Hsap --------APSSYDPLALSELPG----------------LFDCEMLDA------------ CG15072_Dmel -----------QRRTGL-------------------------LTVTER------------ kin-29_Cele ------------------------------------------------------------ QIK_Mmus --------TASSYDPLALSELPG----------------LFDCEMVEA------------ QSK_Mmus --------SDDAY--VQLDTLPGMS--------LVAGKALSSARMSDAVLSQSSLMGSQQ SIK_Mmus --------LSPGCDPAGLP--------------------QGDCEMEDL------------ DDB0231454_Ddis IVFRIRKKENPNTGSIKTFILPYIIDLESTNGTFLKGEKIEPA---------------KY QSK_Spur ------------------------------------------------------------ SIK_Spur --------EAPSYEDS-MD--------------------TSDITVP-V------------ CG4290_Dmel --------FTPNWQSLV-------------------------KPLSES------------ AqueK068_Aque --------ALQLS--LQYMHIG------------------GDSQL--------------- AqueK069_Aque --------SKSGVNLLSLSDNQSS----------------YDTEHVKELDAN-------- SIK_Hsap ------------------------------------------------------------ QSK_Hsap FQD---------GENEECGASLGGHEHPDLSDGSQHLNSSCYPSTCITDILLSY------ QIK_Hsap ------------------------------------------------------------ CG15072_Dmel ------------------------------------------------------------ kin-29_Cele ------------------------------------------EYLC--DQLICR------ QIK_Mmus ------------------------------------------------------------ QSK_Mmus FQD---------EEDEECGVSLG-HEHPGLGDGSQHLNSSRYPATCVTDIMLSH------ SIK_Mmus ------------------------------------------------------------ DDB0231454_Ddis FEL---------RPKD------------K----------ITFGTSTREYILLCE------ QSK_Spur ------------------------------------------------------------ SIK_Spur ------------------------------------------------------------ CG4290_Dmel ------------------------------------------------------------ AqueK068_Aque -----------------------------------------YQSLC-------------- AqueK069_Aque --EAAKLQNFKIVFD------------EKLSADG--------EHCCI-EAVFCGQSISKE SIK_Hsap --MPC--SLGTFVLVQ QSK_Hsap KHPEV--SFSMEQAGV QIK_Hsap --VDP--QHNGYVLVN CG15072_Dmel --PPG--ALERLTKIL kin-29_Cele -----LRMIDPSWSSE QIK_Mmus --VDP--QHNGYVLVN QSK_Mmus KHPEV--SFSMEQAGV SIK_Mmus --TSG--QRGTFVLVQ DDB0231454_Ddis DSIEG--DESEEEDSD QSK_Spur --------QMQQHQHH SIK_Spur --SQA--GNNFSFTPC CG4290_Dmel --PIL--EISEHLESV AqueK068_Aque --TEL--APHFVPSVQ AqueK069_Aque TKLEGSEDFEGRQTTS