CLUSTAL W (1.83) multiple sequence alignment ARAF_Hsap MEP-PRGPPA-------------------------------------------------- RAF1_Hsap MEH-IQGAWKTIS----------------------------------------------- BRAF_Hsap MAA-LSGGGGG-------------------GAEPGQALFNGDMEPEAGAGAGAAASSAAD ksr-2_Cele MSD-EKKKKRGFF--------------------------R--------------YSVLTT lin-45_Cele MSR-INFKKSSAS------------------------------------------TTPTS Raf_Spur MGD-RT------------------------------------------------------ ARAF_Mmus MEP-PRGPPV-------------------------------------------------- BRAF_Mmus MAA-LSGGGGSSSGGGGGGGGGGGGGDGGGGAEQGQALFNGDMEPEAG--AGAAASSAAD RAF1_Mmus MEH-IQGAWKTIS----------------------------------------------- phl_Dmel MSS-ESSTEGD--------------------------------------------SDLYD AqueK677_Aque MES-AQF----------------------------------------------------- AqueK678_Aque DYFIPSA----------------------------------------------------- AqueK679_Aque MAT-DSATE--------------------------------------------------- ARAF_Hsap ------------------------------------------------------------ RAF1_Hsap ------------------------------------------------------------ BRAF_Hsap PAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLL ksr-2_Cele SS-------------------------FSSWRRSST--SG----------SISQSSR--- lin-45_Cele PHC-------------------------------PSPRLISLP----------------- Raf_Spur --KTEQLNVIHMHMELKKKNIEELMERFGTEQPPPPIFLEEYQDLTDQLSELQVEEQRIN ARAF_Mmus ------------------------------------------------------------ BRAF_Mmus PAIPEEVWNIKQMIKLTQEHIEALLDKFGGEHNPPSIYLEAYEEYTSKLDALQQREQQLL RAF1_Mmus ------------------------------------------------------------ phl_Dmel P-LAEELHNVQLVKHVTRENIDALNAKFANLQEPPAMYLIEYQELTSKLHELEAKEQELM AqueK677_Aque ----LEVQAIRQVIRSTRTTLDEFQRSFPYGQR-TSLVVEEESELKKRLEDLMRREKELS AqueK678_Aque ----STLHATEIANHITEINLEKSETKYINIRESPSMAAGAVEVVTNQVEEREAAK-ECV AqueK679_Aque ------------------------------------------------------------ ARAF_Hsap ------------------------------------------------------------ RAF1_Hsap ----NGFGF-----------KDAVFDGSSCISPTIV------QQFGY-QRRA-------- BRAF_Hsap ESLGNGTDFSV---SSSA-SMDTVTSSSSSSLSVLP------SSLSV-FQNP-------- ksr-2_Cele TTSKTTTSSSV---TSSN-PINAPPPTATSSSSVLP------S----------------- lin-45_Cele --------RCA---SSSIDRKDQASPMASPSTPLYPKHSDSLHSLSG-HHSA-------- Raf_Spur NEMSNGH--------TSP-NLQTTPPPEPADLHVPYHNK---QSLAP-PHKR-------- ARAF_Mmus ------------------------------------------------------------ BRAF_Mmus ESLGNGADFSV---SSSA-SMDTVTSSSSSSLSVLP------SSLSV-FQTP-------- RAF1_Mmus ----NGFGL-----------KDAVFDGSSCISPTIV------QQFGY-QRRA-------- phl_Dmel ERLNSQDQQED---SSLV-ERFKEQPHYQNQTQIL-QQQ---RQLARVHHGNDL------ AqueK677_Aque GQG---WDSSD-----SA-EQELVSSSSPDGSDQSP------RGPLS-PRNP-LTVSHSY AqueK678_Aque ESLVSQHRKEDCQQKECL-KIDEYGISSIS------------------------------ AqueK679_Aque ------------------------------------------------------------ ARAF_Hsap ------------------------------NGAEPSRAVGTVKVYLPNKQRTVVTVRDGM RAF1_Hsap ------------------S-D-------DGKLTDPSKTSNTIRVFLPNKQRTVVNVRNGM BRAF_Hsap ------------------T-D-------VARSNPKSPQKPIVRVFLPNKQRTVVPARCGV ksr-2_Cele -----------------------------TSSEPPPPA---------------------- lin-45_Cele ------------------G-G-AG----TSDKEPPKFKYKMIMVHLPFDQHSRVEVRPGE Raf_Spur ------------------E-F-------TNQQHPKSPLSQSVRAFLPNQQRTSVLAKSGT ARAF_Mmus ------------------------------SGAEPSRAVGTVKVYLPNKQRTVVTVREGM BRAF_Mmus ------------------T-D-------ASRNNPKSPQKPIVRVFLPNKQRTVVPARCGV RAF1_Mmus ------------------S-D-------DGKLTDSSKTSNTIRVFLPNKQRTVVNVRNGM phl_Dmel ------------------T-DSLGSQPGSQCGTLTRQPKILLRAHLPNQQRTSVEVISGV AqueK677_Aque PLSPVRHLPPLPPVTVSIEND--T----VAPSSPVTTHAALIRAHLPEGQRTIVPIRQGV AqueK678_Aque -----------------------------KCTTLLREKQVLIRAHLPEGQRTIVPIRQGV AqueK679_Aque ------------------------------------------------------------ ARAF_Hsap SVYDSLDKALKVRGLNQDCCVVYRLI---KGRKT----VTAWDTAIAPLDGEELIV--EV RAF1_Hsap SLHDCLMKALKVRGLQPECCAVFRLLHEHKGKKA----RLDWNTDAASLIGEELQV--DF BRAF_Hsap TVRDSLKKALMMRGLIPECCAVYRIQ---DGEKK----PIGWDTDISWLTGEELHV--EV ksr-2_Cele ------------------------------------------------------------ lin-45_Cele TARDAISKLLKKRNITPQLCHVNASS---DPKQESIELSLTMEEIASRLPGNELWVHSEY Raf_Spur TLKYCLSKAMKMRELTPEMCIVYRV-----NPRM----ALSWDTDMMYLAGEEISV--EL ARAF_Mmus SVYDSLDKALKVRGLNQDCCVVYRLI---KGRKT----VTAWDTAIAPLDGEELIV--EV BRAF_Mmus TVRDSLKKALMMRGLIPECCAVYRIQ---DGEKK----PIGWDTDISWLTGEELHV--EV RAF1_Mmus SLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKA----RLDWNTDAASLIGEELQV--DF phl_Dmel RLCDALMKALKLRQLTPDMCEVSTTH---SG-RH----IIPWHTDIGTLHVEEIFV--RL AqueK677_Aque TIQDALMKAMKTRNLTPNTCIVYA-----ESPRL----LIEWDTDTTQLSGKEVFV--EY AqueK678_Aque TIQDALMKAMKTRNLTPNTCIVYA-----ESPRL----LIEWDTDTTQLSGKEVFV--VV AqueK679_Aque ------------------------------------------------------------ ARAF_Hsap L-EDVPL---TMHNFV-RKTFFSLAFCDFCLKF----------LFHGFRCQTCGYKFHQH RAF1_Hsap L-DHVPL---TTHNFA-RKTFLKLAFCDICQKF----------LLNGFRCQTCGYKFHEH BRAF_Hsap L-ENVPL---TTHNFV-RKTFFTLAFCDFCRKL----------LFQGFRCQTCGYKFHQR ksr-2_Cele ---SAPPRISIYHKMVPSKS--KFRQCDVCEHIFIFDFVRKQHLDDVYACNVCGIRVHKG lin-45_Cele L-NTVSS---IKHAIV-RRTFIPPKSCDVCNNPI---------WMMGFRCEFCQFKFHQR Raf_Spur KAQNFPAPSSISHNFV-RKTFFAIAFCDSCQKL----------LFHGFRCQTCSYKFHQR ARAF_Mmus L-EDVPL---TMHNFV-RKTFFSLAFCDFCLKF----------LFHGFRCQTCGYKFHQH BRAF_Mmus L-ENVPL---TTHNFV-RKTFFTLAFCDFCRKL----------LFQGFRCQTCGYKFHQR RAF1_Mmus L-DHVPL---TTHNFA-RKTFLKLAFCDICQKF----------LLNGFRCQTCGYKFHEH phl_Dmel L-DKFPIRTHIKHQII-RKTFFSLVFCEGCRRL----------LFTGFYCSQCNFRFHQR AqueK677_Aque Q-KSPKLASTNHHNFV-RKTFIALAFCDVCKKL----------LFQGFRCETCGFRYHQR AqueK678_Aque F-MAYPFLSLFHHFFV-RKTFIALAFCDVCKKL----------LFQGFRCETCGFRYHQR AqueK679_Aque ------------------------------------------------------------ ARAF_Hsap CSSKVPTVCVDMSTNR--QQFY-HSV-----QDL--------------SGGSRQHE-APS RAF1_Hsap CSTKVPTMCVDWSNIR--QLLL-FPN-----STI---------------GDSGVPA-LPS BRAF_Hsap CSTEVPLMCVNYDQLD--LLFV-SKF--FEHHPIPQEEA---SLAETALTSGSSPS-APA ksr-2_Cele CLDRVKNDCKITTQYM--GGIL-E------NAVIQ--------------SNKKQWE-KPT lin-45_Cele CSSFAPLYCDLLQSVPKNEDLVKELFGIASQVEGPDRSVAEIVLANLAPTSGQSPAATPD Raf_Spur CANKVPTICISTTGDN---LYK-LLL--ALRKE--DDYN---DYPDT---FPDEPE-SPS ARAF_Mmus CSSKVPTVCVDMSTNR--RQFY-HSI-----QDL--------------SGGSRQQE-APS BRAF_Mmus CSTEVPLMCVNYDQLD--LLFV-SKF--FEHHPVPQEEA---SFPETALPSGSS-S-APP RAF1_Mmus CSTKVPTMCVDWSNIR--QLLL-FPN-----STV---------------GDSGVPA-PPS phl_Dmel CANRVPMLCQPFPMDS---YYQ-LLL--AENPDN---GV---GFPG-------RGT-AVR AqueK677_Aque CSPRVPIQCGGVDDDL---IMA-YIL--SQHPPKPDD--------------SPQPS-SPV AqueK678_Aque CSPRVPIQCGGVDDDL---IMA-YIL--SQHPPKPDD--------------SPQPS-SPV AqueK679_Aque ------------------------------------------------------------ ARAF_Hsap N--RPLNELLTPQG-PSPRTQHCDPEHFP----FPA--P---ANAPLQRIRSTSTPNVHM RAF1_Hsap LTMRRMRESVSRMP-VSSQHRYSTPHAFTFNTSSPS--S---EGSLSQRQRSTSTPNVHM BRAF_Hsap S--DSI----GPQILTSPSPSKSIPIPQPFRPADED--H---RNQFGQRDRSSSAPNVHI ksr-2_Cele T--ASISKSLTTSP-TCSTSTTMSPAGVESMLEK-----WNKTKFLKNRENICKIENVHK lin-45_Cele S--S------HPDLTSIKRTGGVKRHPMAVSPQNET--SQLSPSGPYPRDRSSSAPNINA Raf_Spur -------------------SD------------DQD--F---PRNTLPRERSTSAPNICQ ARAF_Mmus N--LSVNELLTPQG-PSPFTQQRDQEHFS----FPA--P---ANPPLQRIRSTSTPNVHM BRAF_Mmus S--DST----GPQILTSPSPSKSIPIPQPFRPADED--H---RNQFGQRDRSSSAPNVHI RAF1_Mmus FPMRRMRESVSRMP-ASSQHRYSTPHAFTFNTSSPS--S---EGSLSQRQRSTSTPNVHM phl_Dmel FNMSSRSRSR-RCS-SSGSSSSSKPPSSSSGNHRQG--R---PPRISQDDRSNSAPNVCI AqueK677_Aque -----------PH---SP----TVPLLVPTKGGDEGETH-SRFLNTSSRERSISTPNVLY AqueK678_Aque -----------PH---SP----TVPLLVPTKGGDEGETH-SRFLNTSSRERSISTPNVLY AqueK679_Aque ------------------------------------------------------------ ARAF_Hsap VSTTAPM----DSNLIQLTGQS--FS---------------------------------- RAF1_Hsap VSTTLPV----DSRMIEDAIRS--HS---------------------------------- BRAF_Hsap NT-IEPVN--IDDL--------------IRDQ-----------------GFRGDGAPLNQ ksr-2_Cele TRKLISM----TTSTLDDVT---------------------------------------- lin-45_Cele INDEATVQH--NQRIL-DALEAQRLEEESRDKTGSLLSTQARHRPHFQSGHILSGARMNR Raf_Spur NAVNVPG----Q--QFDSE--A--FSRFAFPV----------KSSLNPNGHTASA-AV-- ARAF_Mmus VSTTAPM----DSSLMQFTAQS--FS---------------------------------- BRAF_Mmus NT-IEPVN--IDEKFPEVELQD--QRDLIRDQ-----------------GFRGDGAPLNQ RAF1_Mmus VSTTLHV----DSRMIEDAIRS--HS---------------------------------- phl_Dmel NN-IRSVTSEVQRSLIMQ------------------------------------------ AqueK677_Aque NS---PAN--YDPYPTT--TED--NREFLGPM-----------------PFSSV------ AqueK678_Aque NS---PAN--YDPYPTT--TED--NREFLGPM-----------------PFSSV------ AqueK679_Aque ------------------------------------------------------------ ARAF_Hsap ----------TD-A---AGS---------------------------------------- RAF1_Hsap ----------ES-A---SPS---------------------------------------- BRAF_Hsap LMRCL--RKYQS-R---TPSPLLHSVPSEIVFDFEPGPVF-------------------- ksr-2_Cele ------------------------------------------------------------ lin-45_Cele LHPLVDCTPLGS-N---SPSSTCSSPPGGLIGQ--------------------------- Raf_Spur -------NIHGAHGGGHGKVLTPNSAVQDGVFDYDPTNIANDGHTASAAVNIHGAHG--- ARAF_Mmus ----------TD-A---AG----------------------------------------- BRAF_Mmus LMRCL--RKYQS-R---TPSPLLHSVPSEIVFDFEPGPVF-------------------- RAF1_Mmus ----------ES-A---SPS---------------------------------------- phl_Dmel ------------------------------------------------------------ AqueK677_Aque ---------SGS-Y---VDNHLSHSTEYNSVFDYNVSSSGNSSRDAPIAHPPHSRRGLCG AqueK678_Aque ---------SGS-Y---VDNHLSHSTEYNSVFDYNVSSSGNSSRDAPIAHPPHSRRGLCG AqueK679_Aque ------------------------------------------------------------ ARAF_Hsap ------------------------------------------------------RG---- RAF1_Hsap ------------------------------------------------------------ BRAF_Hsap ------------------------------------------------------RGSTT- ksr-2_Cele ------------------------------------------------------------ lin-45_Cele ------------------------------------------------------------ Raf_Spur -------------------------GGHGKVLTPNSAVQD----GVFDYDPTNIANGLAS ARAF_Mmus ------------------------------------------------------RG---- BRAF_Mmus ------------------------------------------------------RGSTT- RAF1_Mmus ------------------------------------------------------------ phl_Dmel ------------------------------------------------------------ AqueK677_Aque RGHISTSALETSHTGMDAMRIERRRKGHKRQSSAGHLDYSGVEDSKER------RNSTE- AqueK678_Aque RGHISTSALETSHTGMDAMRIERRRKGHKRQSSAGHLDYSGVEDSKER------RNSTE- AqueK679_Aque ------------------------------------------------------------ ARAF_Hsap G-----------------------SDGTPRGSPSPASVS--------------------- RAF1_Hsap A-----------------------------LSSSPNNLSP-------------------- BRAF_Hsap G-----------------------LSATPPA-SLPGSLT--------------------- ksr-2_Cele ------------------------------------------------------------ lin-45_Cele ----------------------------PTLGQSPN-VSGST----TSSLVAAHLHTLPL Raf_Spur S-----------------------LPNTRNLIHSPKRESG-------------------- ARAF_Mmus ------------------------GDGAPRGSPSPASVS--------------------- BRAF_Mmus G-----------------------LSATPPA-SLPGSLT--------------------- RAF1_Mmus A-----------------------------LSSSPNNLSP-------------------- phl_Dmel --------------------------ARPPL-PHPCTDH--------------------- AqueK677_Aque GRSPMERRLHSSSERHRHRSLERRSSSGDRTSATPDSMSP-SYSTGQS---------PLQ AqueK678_Aque GRSPMERRLHSSSERHRHRSLERRSSSGDRTSATPDSMSP-SYSTGQS---------PLQ AqueK679_Aque ------------------------------------------------------------ ARAF_Hsap ------------------------SGRKSPHSKSPAEQ-RERK----SLADDKKKVKN-- RAF1_Hsap ------------------------TGWSQPKTPVPA-Q-RERAPV--SGTQEKNKIRP-- BRAF_Hsap ------------------------NVKALQKS--PGPQ-RERKSS--SSSEDRNRMKT-- ksr-2_Cele --------------------------------------------T--FNSEINEEMDE-- lin-45_Cele TPPQ----------------------SAPPQKISPGFF-RNRSRS--PGERLDAQRPR-- Raf_Spur -------------------------SHSSQPS--PTHQPRWKDVLPGS-DSKDNKIKPPT ARAF_Mmus ------------------------SGRKSPHSKLPSEQ-RERK----SLADEKKKVKN-- BRAF_Mmus ------------------------NVKALQKS--PGPQ-RERKSSSSSSSEDRSRMKT-- RAF1_Mmus ------------------------TGWSQPKTPVPA-Q-RERAPG--SGTQEKNKIRP-- phl_Dmel ----------------------SNSTQASPTSTLKH-N-RPRARS---ADESNKNLLL-- AqueK677_Aque TPTGSKPPLQTSLSSGDSGLGGSRSSTSYSSSTLPS-Q-RRRQRT---SSEDKRA--K-- AqueK678_Aque TPTGSKPPLQTSLSSGDSGLGGSRSSTSYSSSTLPS-Q-RRRQRT---SSEDKRALQK-- AqueK679_Aque ------------------------------------------------------------ ARAF_Hsap ------LGYRDSGYYWEVPPSEVQ-LLKRIGTGSFGTVFRGRWHGDVAV-KVLKV----- RAF1_Hsap ------RGQRDSSYYWEIEASEVM-LSTRIGSGSFGTVYKGKWHGDVAV-KILKV----- BRAF_Hsap ------LGRRDSSDDWEIPDGQIT-VGQRIGSGSFGTVYKGKWHGDVAV-KMLNV----- ksr-2_Cele ------ETVLMTWEDVTIKLTDVD-VMTKIGDGRFGSVYFGGYHGNAAV-RFVNM----- lin-45_Cele ------PPQKPHHEDWEILPNEFI-IQYKVGSGSFGTVYRGEFFGTVAI-KKLNV----- Raf_Spur TLLGHRRTRRDSNDDWEIPTEEIR-LGSRIGAGSFGTVFSGQWHGSVAV-KRLNV----- ARAF_Mmus ------LGYRDSGYYWEVPPSEVQ-LLKRIGTGSFGTVFRGRWHGDVAV-KVLKV----- BRAF_Mmus ------LGRRDSSDDWEIPDGQIT-VGQRIGSGSFGTVYKGKWHGDVAV-KMLNV----- RAF1_Mmus ------RGQRDSSYYWEIEASEVM-LSTRIGSGSFGTVYKGKWHGDVAV-KILKV----- phl_Dmel ------RDAKSSEENWNILAEEIL-IGPRIGSGSFGTVYRAHWHGPVAV-KTLNV----- AqueK677_Aque ------VKCKDSSDVWEIPYNEIE-VGERIGSGSFGTVYKGKWHGPVAV-KKLNV----- AqueK678_Aque ------VKCKDSSDVWEIPYNEIE-VGERIGSGSFGTVYKGKWHGPVAV-KKLNV----- AqueK679_Aque --------------DGEFKFRQVTILKETLGNGAYGVVYKAKCDELICAAKYMHPIFFAL . :. : :* * :* *: . . : :: ARAF_Hsap -SQPTAE--QAQAFKNEM-QVLRKTRHVNILLFMGFMTRP---GFAIITQWCE--GSSLY RAF1_Hsap -VDPTPE--QFQAFRNEV-AVLRKTRHVNILLFMGYMTKD---NLAIVTQWCE--GSSLY BRAF_Hsap -TAPTPQ--QLQAFKNEV-GVLRKTRHVNILLFMGYSTKP---QLAIVTQWCE--GSSLY ksr-2_Cele -NYLSQEDRRADVFATEIVSAYKNSRHDHIALFYGYVSDPVTNTYAIVTNFYQ--HNTLY lin-45_Cele -VDPTPS--QMAAFKNEV-AVLKKTRHLNVLLFMGWVREP---EIAIITQWCE--GSSLY Raf_Spur -KDPTPS--QLQAFKNEV-AVLRKTRHANILLFMGCTSKP---QLAIVTQWCE--GSSLY ARAF_Mmus -AQPTAE--QAQAFKNEM-QVLRKTRHVNILLFMGFMTRP---GFAIITQWCE--GSSLY BRAF_Mmus -TAPTPQ--QLQAFKNEV-GVLRKTRHVNILLFMGYSTKP---QLAIVTQWCE--GSSLY RAF1_Mmus -VDPTPE--QLQAFRNEV-AVLRKTRHVNILLFMGYMTKD---NLAIVTQWCE--GSSLY phl_Dmel -KTPSPA--QLQAFKNEV-AMLKKTRHCNILLFMGCVSKP---SLAIVTQWCE--GSSLY AqueK677_Aque -SNPTEQ--QMQAFKNEV-AVLMKTRHANILLFMGWTSKP---RLTIVTQWCD--GSTLF AqueK678_Aque -SNPTEQ--QMQAFKNEV-AVLMKTRHANILLFMGWTSKP---RLTIVTQWCD--GSTLF AqueK679_Aque SEDPAVNVVATDKFKKEC-QLLSRLKHPNIVQYLGTHEVN---GIDTVVLLMELMDSSLH : * .* . :* :: : * :. : .:*. ARAF_Hsap HHLHVA-DTR--FDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGL-TVKIGD RAF1_Hsap KHLHVQ-ETK--FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL-TVKIGD BRAF_Hsap HHLHII-ETK--FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDL-TVKIGD ksr-2_Cele HRIHEQLSED--FDQSWTFQISLQICQAMSYLHKKKILHRDLRTKNILLDNPN-RVVVTD lin-45_Cele RHIHVQ-EPRVEFEMGAIIDILKQVSLGMNYLHSKNIIHRDLKTNNIFLMDDMSTVKIGD Raf_Spur KHLHVL-DTK--LVMHQLIDISRQTAQGMDYLHAKNIIHRDLKSNNIFLHDDL-TVKIGD ARAF_Mmus HHLHVA-DTR--FDMVQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGL-TVKIGD BRAF_Mmus HHLHII-ETK--FEMIKLIDIARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDL-TVKIGD RAF1_Mmus KHLHVQ-ETK--FQMFQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGL-TVKIGD phl_Dmel KHVHVS-ETK--FKLNTLIDIGRQVAQGMDYLHAKNIIHRDLKSNNIFLHEDL-SVKIGD AqueK677_Aque SHIHVL-EDR--FEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDM-TVKIGD AqueK678_Aque SHIHVL-EDR--FEMYKIIDICRQTAQGVDYLHAKQIIHRDLKSNNIFLHDDM-TVKIGD AqueK679_Aque AYLHAHVDSP--LPFHQEINISLDVARALDYLHVNNIHHRDLSAKNILMLGDY-RAKVSD :* . : ::: : . .:.*** :.* ***: ::**:: . : * ARAF_Hsap FGLATVKTRWS--GAQPLEQPSGSVLWMAAEV-----------IRMQDPNPYSFQSDVYA RAF1_Hsap FGLATVKSRWS--GSQQVEQPTGSVLWMAPEV-----------IRMQDNNPFSFQSDVYS BRAF_Hsap FGLATVKSRWS--GSHQFEQLSGSILWMAPEV-----------IRMQDKNPYSFQSDVYA ksr-2_Cele FALMKLERLENPRRNCTLLIPNHWIDYLSPEIAGNLMIDWRGDVLFQHELPFSQESDVYS lin-45_Cele FGLATVKTKWTVNGGQQQQQPTGSILWMAPEV-----------IRMQDDNPYTPQSDVYS Raf_Spur FGLATVKSRWS--GSQQFEQPSGSILWMAPEV-----------IRMRDTNPYSFQSDVYA ARAF_Mmus FGLATVKTRWS--GAQPLEQPSGSVLWMAAEV-----------IRMQDPNPYSFQSDVYA BRAF_Mmus FGLATVKSRWS--GSHQFEQLSGSILWMAPEV-----------IRMQDKNPYSFQSDVYA RAF1_Mmus FGLATVKSRWS--GSQQVEQPTGSVLWMAPEV-----------IRMQDDNPFSFQSDVYS phl_Dmel FGLATAKTRWS--GEKQANQPTGSILWMAPEV-----------IRMQELNPYSFQSDVYA AqueK677_Aque FGLATVKTRWD--GNEKVRQPTGSILWMAPEV-----------IRMEEPDPYTFYCDVYS AqueK678_Aque FGLATVKTRWD--GNEKVRQPTGSILWMAPEV-----------IRMEEPDPYTFYCDVYS AqueK679_Aque FGQSKLRNPNG--GFSSNSPCPGNILYMPPET-----------LKVP--PDFAPTLDEFS *. . . : ::..* : . :: * :: ARAF_Hsap YGVVLYELMTGSLPYSHIGCRDQIIF--MVGRGYLSPDLSKISSNC-----PKAMRRLLS RAF1_Hsap YGIVLYELMTGELPYSHINNRDQIIF--MVGRGYASPDLSKLYKNC-----PKAMKRLVA BRAF_Hsap FGIVLYELMTGQLPYSNINNRDQIIF--MVGRGYLSPDLSKVRSNC-----PKAMKRLMA ksr-2_Cele FGTIFFELLLRRMPTG-CDSWDQKLYAKMCGQKAALQRLDAQLQKI-----DGKLHELLL lin-45_Cele FGICMYEILSSHLPYSNINNRDQILF--MVGRGYLRPDRSKIRHDT-----PKSMLKLYD Raf_Spur FGVVLFELVTQSLPYQNIKHKDQIIW--MVGRGYLQPDLSKVRNDT-----PKALKRLIT ARAF_Mmus YGVVLYELMTGSLPYSHIGSRDQIIF--MVGRGYLSPDLSKIFSNC-----PKAMRRLLT BRAF_Mmus FGIVLYELMTGQLPYSNINNRDQIIF--MVGRGYLSPDLSKVRSNC-----PKAMKRLMA RAF1_Mmus YGIVLYELMAGELPYAHINNRDQIIF--MVGRGYASPDLSRLYKNC-----PKAMKRLVA phl_Dmel FGIVMYELLAECLPYGHISNKDQILF--MVGRGLLRPDMSQVRSDA-----PQALKRLAE AqueK677_Aque FGVVVYELISGQLPYPHVQDRDQILF--MVGRGFLRPDPSSARKDT-----PKSFKQLCI AqueK678_Aque FGVVVYELISGQLPYPHVQDRDQILF--MVGRGFLRPDPSSARKDT-----PKSFKQLCI AqueK679_Aque FGIVTIQIMSRKDPKPSDLHRTG--SL--IGTLVEVPEIERRRDDIDSCDPSNPILGLSI :* ::: * * . . : * ARAF_Hsap DCLKFQREERPLFPQILATIELLQRSLPKIE----------------------------- RAF1_Hsap DCVKKVKEERPLFPQILSSIELLQHSLPKIN----------------------------- BRAF_Hsap ECLKKKRDERPLFPQILASIELLARSLPKIH----------------------------- ksr-2_Cele ECWSSQPEKRPSFQQIVKRITV---QMPR------------------------------- lin-45_Cele NCIMFDRNERPVFGEVLERLRDI--ILPKLT----------------------------- Raf_Spur DCYALNRDERPLFPVVLAALESLARQLPKIH----------------------------- ARAF_Mmus DCLKFQREERPLFPQILATIELLQRSLPKIE----------------------------- BRAF_Mmus ECLKKKRDERPLFPQILASIELLARSLPKIH----------------------------- RAF1_Mmus DCVKKVKEERPLFPQILSSIELLQHSLPKIN----------------------------- phl_Dmel DCIKYTPKDRPLFRPLLNMLENMLRTLPKIH----------------------------- AqueK677_Aque KCCQFEKDDRPLFHQILADLESLSDSMPKIK----------------------------- AqueK678_Aque KCCQFEKDDRPLFHQVYNNLESLSDSMPKIK----------------------------- AqueK679_Aque SCISNDPQERPPIERMCQLLSLLKNT-SQYKKSAMGLSSSSDEGKENVHPFEDYGEVLIV .* ..** : : : .: ARAF_Hsap ------------------------------------------------------------ RAF1_Hsap ------------------------------------------------------------ BRAF_Hsap ------------------------------------------------------------ ksr-2_Cele ------------------------------------------------------------ lin-45_Cele ------------------------------------------------------------ Raf_Spur ------------------------------------------------------------ ARAF_Mmus ------------------------------------------------------------ BRAF_Mmus ------------------------------------------------------------ RAF1_Mmus ------------------------------------------------------------ phl_Dmel ------------------------------------------------------------ AqueK677_Aque ------------------------------------------------------------ AqueK678_Aque ------------------------------------------------------------ AqueK679_Aque ELNENDTHYSSKIDDLTRTIKDKENLLKDQSNILELRNKQLLQKSNIIDKYKLQLEEKES ARAF_Hsap -------------------------------RSASE------------------------ RAF1_Hsap -------------------------------RSASE------------------------ BRAF_Hsap -------------------------------RSASE------------------------ ksr-2_Cele --------------------------------KESN------------------------ lin-45_Cele -------------------------------RSQSA------------------------ Raf_Spur -------------------------------RSASE------------------------ ARAF_Mmus -------------------------------RSASE------------------------ BRAF_Mmus -------------------------------RSASE------------------------ RAF1_Mmus -------------------------------RSASE------------------------ phl_Dmel -------------------------------RSASE------------------------ AqueK677_Aque -------------------------------RSNSE------------------------ AqueK678_Aque -------------------------------RSNSE------------------------ AqueK679_Aque EDAEADKKKSQLEIYNLELETKVSELKDQLNRKESEVIEKEKQLMEKEEQLRRKEEAIVA . * ARAF_Hsap ---------------------------------------------------------PS- RAF1_Hsap ---------------------------------------------------------PS- BRAF_Hsap ---------------------------------------------------------PS- ksr-2_Cele ---------------------------------------------------------KQ- lin-45_Cele ---------------------------------------------------------PN- Raf_Spur ---------------------------------------------------------PS- ARAF_Mmus ---------------------------------------------------------PS- BRAF_Mmus ---------------------------------------------------------PS- RAF1_Mmus ---------------------------------------------------------PS- phl_Dmel ---------------------------------------------------------PN- AqueK677_Aque ---------------------------------------------------------PT- AqueK678_Aque ---------------------------------------------------------PN- AqueK679_Aque QQVSSDERYSICVSELEQLRAELDHLQAEQAAKTPDSPFSLEPPFLSQPVPFEDNKQPRI ARAF_Hsap ------------------------------------------------LHRTQ--A---- RAF1_Hsap ------------------------------------------------LHRAA-HT---- BRAF_Hsap ------------------------------------------------LNRAGFQT---- ksr-2_Cele ------------------------------------------------KRRSTAH----- lin-45_Cele ------------------------------------------------VLHLDSQY---- Raf_Spur -----------------------------------------------SLNRARLHS---- ARAF_Mmus ------------------------------------------------LHRTQ--A---- BRAF_Mmus ------------------------------------------------LNRAGFQT---- RAF1_Mmus ------------------------------------------------LHRAA-HT---- phl_Dmel ------------------------------------------------LTQSQLQN---- AqueK677_Aque -----------------------------------------------TLCYAGLSY---- AqueK678_Aque ------------------------------------------------LIKQNIQN---- AqueK679_Aque PKKPKQLDLKWQTRKQSPVAFQPQSSMAVACMDKIYITYCNYSRSEGKIYEYSLSTDTWT ARAF_Hsap ----------------------------------------------DEL----------- RAF1_Hsap ----------------------------------------------EDI----------- BRAF_Hsap ----------------------------------------------EDF----------- ksr-2_Cele ------------------------------------------------------------ lin-45_Cele ----------------------------------------------SVM---------DA Raf_Spur ----------------------------------------------DDF----------- ARAF_Mmus ----------------------------------------------DEL----------- BRAF_Mmus ----------------------------------------------EDF----------- RAF1_Mmus ----------------------------------------------EDI----------- phl_Dmel ----------------------------------------------DEF----------- AqueK677_Aque ----------------------------------------------QEE----------- AqueK678_Aque ----------------------------------------------QKY----------- AqueK679_Aque QLPLLRKSEFSLAVVNNDYIVAVGGSAALRKSGSILKYLSASSKWVKEFPDMPTPRSFPS ARAF_Hsap ------------------------------------------------------------ RAF1_Hsap ------------------------------------------------------------ BRAF_Hsap ------------------------------------------------------------ ksr-2_Cele ------------------------------------------------------------ lin-45_Cele VMRSQ------------------------------------------------------- Raf_Spur ------------------------------------------------------------ ARAF_Mmus ------------------------------------------------------------ BRAF_Mmus ------------------------------------------------------------ RAF1_Mmus ------------------------------------------------------------ phl_Dmel ------------------------------------------------------------ AqueK677_Aque ------------------------------------------------------------ AqueK678_Aque ------------------------------------------------------------ AqueK679_Aque CVTVGNYLVVAGGEVNSEPVPVVEILDVTKMTWHFVLPFPTRNISRMTVSTDGTFAYFLG ARAF_Hsap ----------------------------------------P--ACLLSAA---------- RAF1_Hsap ----------------------------------------N--ACTLTTSP--------- BRAF_Hsap ----------------------------------------SLYACASPKTPIQA-GG--- ksr-2_Cele ------------------------------------------------------------ lin-45_Cele -----M-------------------------------LSWSYIPPATAKTPQSA-AA--- Raf_Spur ----------------------------------------M--YCPSPKTPIQS-QF--- ARAF_Mmus ----------------------------------------P--ACLLSAA---------- BRAF_Mmus ----------------------------------------SLYACASPKTPIQA-GG--- RAF1_Mmus ----------------------------------------N--ACTLTTSP--------- phl_Dmel ------------------------------------------LYLPSPKTPVNF-NN--- AqueK677_Aque -----------------------------------------L--NKSPHTPSHN-SS--- AqueK678_Aque -----------------------------------------L-PMPSYSTPVS------- AqueK679_Aque GFEEGSLSKLAYAVNVSRLIAETERREGKKLWLELSSLPVSGATCASIRNRILALGGYDT ARAF_Hsap ------------------------------------------------------------ RAF1_Hsap ------------------------------------------------------------ BRAF_Hsap ------------------------------------------------------------ ksr-2_Cele ------------------------------------------------------------ lin-45_Cele ----------------------------------------------------AAAANKKA Raf_Spur ----------------------------------------------------A-----V- ARAF_Mmus ------------------------------------------------------------ BRAF_Mmus ------------------------------------------------------------ RAF1_Mmus ------------------------------------------------------------ phl_Dmel ----------------------------------------------------FQ----F- AqueK677_Aque ----------------------------------------------------ATGA--ES AqueK678_Aque ------------------------------------------------------------ AqueK679_Aque MNKSSSDLIYEFDQIEGSWKPTGHLPRPFTRGLVAVATYESRKLLVVIGGNMTNNI--ST ARAF_Hsap ---R-LVP RAF1_Hsap ---RLPVF BRAF_Hsap -YGAFPVH ksr-2_Cele ---ENPLF lin-45_Cele YYNVYGLI Raf_Spur -FPFDMRG ARAF_Mmus ---R-LVP BRAF_Mmus -YGGFPVH RAF1_Mmus ---RLPVF phl_Dmel -FGSAGNI AqueK677_Aque -AFHLVKQ AqueK678_Aque --FLNFSF AqueK679_Aque -ATNIAYL