CLUSTAL W (1.83) multiple sequence alignment RIOK2_Hsap M---------GKVNVAKLRYMSRDDFRVLT--AVEMGMKNHEIVPGSLIASIASLKH-GG CG11859_Dmel M---------GKLNVTVLRYLTKEDFRVLT--AIEMGMKNHELVPGPLAAAIANLKS-GG aSWK440_Cele M---------GRMNVSMMRYLEGDHFRVLI--AVEMGMKNHEVVPLALVSAIAGIHR-GG RIO2_Scer M----------KLDTSHMRYLTTDDFRVLQ--AVEQGSRSHEVVPTPLIHQISGMRSQSG RIOK2_Mmus M---------GKVNVAKLRYMSRDDFRVLT--AVEMGMKNHEIVPCSLIASIASLKH-GG Rio2_Ddis M----------KLDPKALRYLSKDDFRTLV--AVEMGMKNHELVPVSLICTIANLKY-GG 27105_Tthe M----------RLDPSYLEYMTKDEFRVLT--AIEIGMRNHELVPMHLIERISHLKR-VC RIO2_Spur M--------------AAERKISRDRFNAYCSDQLEMGMKNHEIVPSNLVASIANLRH-GG CC1G_13652_Ccin M----------KLDATDLRYVTSEEFRVLT--AVEMGSKNHEIVPTHLIVQISGLRG-GG AqueK050_Aque M---------GRLDVSLLRYLTSQDFRVLT--GVEMGMKNHEIVPAELISSIAGIRS-SG RIO2-2_Smoe M----------KLDVNVLRYLSKDEFRVLT--AVEMGMKNHEIVPAELIDRIAGLKT-GG RIO2-1_Smoe M----------KLDVNVLRYLSKDEFRVLT--AVEMGMKNHEIVPAELIDRIAGLKT-GG GK011_Glam MSKFISLIAMPNLDVSYVDSLPPSYYRVLT--AVEMGMKNHDYVPLNLVISLSGIRH-GS * : . :.. :* * :.*: ** * :: :: RIOK2_Hsap CNKVLRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESD CG11859_Dmel VHKLLKELCKHKLLAYERGKKYDGYRLTNTGYDYLALKSLTLRGSVSSFGNQIGIGKESN aSWK440_Cele VARTLNDLCKHSLVAFERSKKFDGYRLTIRGYDYLALRALCSREVVGSVGNQIGIGKESD RIO2_Scer TNRAISDLAKLSLISKMRNVKYDGYRLTYNGIDYLALKTMLNRDTVYSVGNTIGVGKESD RIOK2_Mmus CNKILRELVKHKLIAWERTKTVQGYRLTNAGYDYLALKTLSSRQVVESVGNQMGVGKESD Rio2_Ddis TKKSIQTLHKFKLLFHDG-RNYDGYKLTYLGYDFLALKTLVSRGVCSYVGNQIGVGKESD 27105_Tthe ASKVVKLLLKNKFIAHEN-KKFDGYKLTYLGYDYLALQVFIRRGAIKEVLGKVGCGKESD RIO2_Spur CHKVLKELVRNKLIAWEH-GKVSGYRLTYPGYDYLALKALVARDAVASVGNQIGVGKESD CC1G_13652_Ccin VNKLIGSLAKRNLISKVQNAKYEGYRLTYGGYDYLAMRALSKRDSMTSVGNQIGVGKESD AqueK050_Aque CYKILRELAKHRLVTYEH-QKVCGYRLTNAGYDYLALRALVSKDVIYSVGNQIGVGKES- RIO2-2_Smoe AYKNIRTLLRHKLVHHDS-TKYDGYRLTNLGYDFLAIKTMVNRGLIVGVGRQIGVGKESD RIO2-1_Smoe AYKNIRTLLRHKLVHHDS-TKYDGYRLTNLGYDFLAIKTMVNRGLIVGVGRQIGVGKESD GK011_Glam IPHIVQELLKIKLISHIG-APIDGYALTYMGYDYLSLNVMKRRGVISAIGSRIGVGKEAD : : * : :: ** ** * *:*::. : : . :* ***: RIOK2_Hsap IYIVANEEGQQFALKLHRLGRTSFRNLKNKRDYHKHR-HNVSWLYLSRLSAMKEFAYMK- CG11859_Dmel IYVVADEEGTPICLKLHRLGRTCFRNVKAKRDYHGRR-HKASWLYLSRISATREFAYMS- aSWK440_Cele VYVGGDPELNDLCLKFHRLGRTSFRKIKEKRDYHKKR-KSASWLYLSRLAAAKEFAFLK- RIO2_Scer IYKVSDKNGNPRVMKIHRLGRTSFHSVRNNRDYLKKSNQGANWMHLSRLAANKEYQFMS- RIOK2_Mmus IYIVANEAGQQLALKLHRLGRTSFRNLKNKRDYHKHR-HNVSWLYLSRLSAMKEFAYMK- Rio2_Ddis IYIVANDDNQEMVLKLHRLGRVSFKTIKNNRDYLKHR-KSASWLYLSRLAALKEFAYMK- 27105_Tthe IYKCVNENGDFVILKFTRLGRTSFRTIKKNRDYIQHR-TSYSWLYLSRLSAIKEYTFMD- RIO2_Spur IYIVANDNDEQLALKLHRLGRTSFRKLKEKRDYLGKR-KSASWLYLSRLAAMKEFAFMK- CC1G_13652_Ccin IYVVANAEGDEMVLKLHRLGRISFRSIKTKRDYMGKR-KSASWMYLSRLSAQKEYAFMK- AqueK050_Aque -------------------GRTSFRKVKEKRDYHRHR-QTTSWLYLSRLAAQKEYTFMKC RIO2-2_Smoe IFEVVAEDGQTLALKLHRLGRTSFRAVKSKRDYLKHR-SSFNWLYLSRLAALKEFAFMK- RIO2-1_Smoe IFEVVAEDGQTLALKLHRLGRTSFRAVKSKRDYLKHR-SSFNWLYLSRLAALKEFAFMK- GK011_Glam VYMAMRPNGQYVVLKLHKLGRTSFKTAKTKRDYMGPR-KSASWMYLSRLAAVREFGFMV- ** .*: : :*** .*::***::* :*: :: RIOK2_Hsap ---------------------ALYERKFPVPKPIDYNRHAVVMELINGYPLCQIHHVE-- CG11859_Dmel ---------------------ALYDRGFPVPKPIDFNRHCVLMDLVKGWPMTQVHELL-- aSWK440_Cele ---------------------ALQERGFPVPKAVDVCRHLVVMQLVVGQTLCNVTHVE-- RIO2_Scer ---------------------MLYSKGFKVPEPFDNSRHIVVMELIEGYPMRRLRKHK-- RIOK2_Mmus ---------------------ALYERKFPVPKPIDYNRHAVIMELINGYPLCQIHHVE-- Rio2_Ddis ---------------------ALYENGFPVPTPIDYNRHCIVMSRARGYPLTQIVQLR-- 27105_Tthe ---------------------LLHKNNFPTPIPIEQNRHGIVMSLINGVPMQNISEID-- RIO2_Spur ---------------------ALYDHGFPVPTPIDFSRHCVVMELMNAYPLNQVHTLD-- CC1G_13652_Ccin ---------------------VLYEHGFPIPKPIDQARHCVLMEFINAYPLRQISEVP-- AqueK050_Aque TCLMKNTFTVSISALFILSFQVLHERGFPVPQPMDVNRHCVVMELINGYPLCQVRSLS-- RIO2-2_Smoe ---------------------ALHEHGFPTPKAVDWNRHCVLMTLVPGYPLVQVKELK-- RIO2-1_Smoe ---------------------ALHEHGFPTPKAVDWNRHCVLMTLVPGYPLVQVKELK-- GK011_Glam ---------------------ALKERSFPVPDPISINRHCVCMSYVEGIPMHAIKDIDIE * .. * * ... ** : * . .: : RIOK2_Hsap DPASVYDEAMELIVKLANHGLIHGDFNEFNLILDES---------DHITMIDFPQMVSTS CG11859_Dmel DAPQVYDDLMNLIVRLGNSGVIHGDFNEFNLMVTDA---------GKPILIDFPQMMSTS aSWK440_Cele DAGALYDRLMALIVKMARHGVIHGDFNEFNLIMLED---------ERIVMIDFPQMVSID RIO2_Scer NIPKLYSDLMCFIVDLANSGLIHCDFNEFNIMIKDKLEDE---NDCGFVVIDFPQCISIQ RIOK2_Mmus DPASVYDEAMELIVKLGNHGLIHGDFNEFNLMLDKD---------DHITMIDFPQMVSTS Rio2_Ddis HPSKVYSDLMNLIVKLASYGLIHGDFNEFNILINDE---------EEITLIDFPQMVSTS 27105_Tthe NPKYVFDQCFYLIKRLAENGLIHSDFNEFNLMVEDN---------GKVIMIDFPQMVSTK RIO2_Spur DPASVYDDLMNLIVRLANHGLIHGDFNEFNLMLDDQ---------DQITLIDFPQMVSTS CC1G_13652_Ccin SPGKLYSTLMDLIVRFAQAGLIHGDFNEFNILIREE--------TGEPVVIDFPQMVSTS AqueK050_Aque KPEVLFNTLMALLVRLASHGLLHCDFNEFNIIISDE---------DKPTLIDFPQMVSTS RIO2-2_Smoe NPALVFDTVISLIVRLAEHGLIHCDFNEFNLLIDDD---------EKVTMIDFPQMVSIS RIO2-1_Smoe NPALVFDTVISLIVRLAEHGLIHCDFNEFNLLIDDD---------EKVTMIDFPQMVSIS GK011_Glam AANLLAKDIHTQMVRMLRYGIVHGDCNEFNAIVQTSDPENCTPETTRVVIIDFPQVIQSI : . : : *::* * **** :: :***** :. RIOK2_Hsap HPNAEW----YFDRDVKCIKDFFMKRFSYES-----------------ELFPTFK-DIRR CG11859_Dmel HENAEF----FFERDVNCVREMFRRKFGYES-----------------EDYPKFS-DLVR aSWK440_Cele HPNAEY----YFDRDVTCVRTFFKRKFDYES-----------------EDWPKFD-EVER RIO2_Scer HQDADY----YFQRDVDCIRRFFKKKLKYEPKPDSSMLDTEGFGDGYKYAYPDFKRDVKR RIOK2_Mmus HPNAEW----YFDRDVKCIREFFMKRFSYES-----------------ELYPTFS-DIRK Rio2_Ddis HLNAEM----YFDRDVTCIRVFFEKRFNFI-----------------GERWPKFK-DCQN 27105_Tthe HKNAQF----YFDRDVECIHVFFERRFNYQ-----------------ITDTLDFN-KIAR RIO2_Spur HENAEW----YFNRDVQCVVDFFNRRFNYKS-----------------ELYPKFS-DITC CC1G_13652_Ccin HENAEW----YFNRDVECIRTFFRRRFRYESN-----------------LYPRFK-RTMA AqueK050_Aque HPDAARYTINYFERDVHCVAEFFSKRFQWRPD----------------EALPSLN-DIMK RIO2-2_Smoe HRNAES----YFDRDVDCIYKFFLKRFNYVPGGNARTLQGIDNNVDEDDTRPDFE-NLAR RIO2-1_Smoe HRNAES----YFDRDVDCIYKFFLKRFNYVPGGNARTLQGIDNNVDEDDTRPDFV-NLAR GK011_Glam APEAEE----QFNRDVMSVEGFFNRRFGAD-----------------I-VLPRYN-EVMR :* *:*** .: :* ::: RIOK2_Hsap -ED-------TLDVE----VSA-SG--YTKEMQADD--EL-L-HPLGPDD---------- CG11859_Dmel -ED-------DLDAE----VHC-TGYGFTKEMEQDL--LEE----YGMVD---------- aSWK440_Cele -KG-------NMDVL----LEA-SG--FTKKMALDL--NKA----YDEGD----FLAHCE RIO2_Scer -TD-------NLDEL----VQA-SG--FSKKHPGDRGLETAV-ESMRNAV---------- RIOK2_Mmus -ED-------SLDVE----VSA-SG--YTKEMQADD--EL-L-HPVGPDD---------- Rio2_Ddis -IH-------SLDVE----ISA-SG--FTRDMEKEF--QDLS-K-QQDDDEINNN----- 27105_Tthe -LN-------DLDVQ----VKA-SG--FIKKEIKNI--DDFDIDLRGSDD---------- RIO2_Spur -EK-------TLDVD----VAA-SG--FSKEMEQSL--EEGT-DALKMDG---------- CC1G_13652_Ccin -EGSADGNDFRLDVI----VEA-SG--FSKNDMKV--LEEYM-EAADLEE---------- AqueK050_Aque -VA-------SLDVE----VNA-SG--AIKEKSAGV--E--------------------- RIO2-2_Smoe TAG-------ALDKE----LAA-SG--FTHQNQEDL------------------------ RIO2-1_Smoe TAG-------ALDKE----LAA-SG--FTHQNQEDL------------------------ GK011_Glam -QI-------SEEELVGQRIDATEA--FVKEMVAKY--D--------PD----------- : : . . :. RIOK2_Hsap ----KNIETKEGSEFSFSDGEVAEKAEVYGSENESERNCLEESEGCYCRS-S-GDPEQIK CG11859_Dmel ----QADEEDEGEDLEEEEEPPTLVTAA-SVEIDECRRQVENE---VIYS-E-AKPTQKS aSWK440_Cele QELRNRQEEDLGEDEDDSDDSKSM-EDI-QEEPEDLEKDHEEL---Q-AQ-E---NTVKQ RIO2_Scer ----YNSD-DDMSND-EAEEENGEG-D------YSEEDE--------------------- RIOK2_Mmus ----KITETEEDSDFTFSDEEMLEKAKVWRSELEKEADPADESGGSWCCS-S-TDSKQIK Rio2_Ddis ----DSDENDEDDDEDDDDDDENND------DDENNDNNIE------------------- 27105_Tthe ----DGDDD-NSDDENEQNDLDKNI------EQEDSDNEIEES-NKRIQNLNILNDEDIS RIO2_Spur ----DC-EDDETDEEDEEEEGVVEE-------MKNPHDGLQDS---------------GS CC1G_13652_Ccin ----EGTGDEEDESE-ESEEEEEEE--------EEEEEEGEES--------E-------- AqueK050_Aque -------EENEGEEEESKEFECSLASHVKGIHITD------------------------- RIO2-2_Smoe ------------------------------------------------------------ RIO2-1_Smoe ------------------------------------------------------------ GK011_Glam -------------EELE---------------IKEGDEAVDEC-SNS------------- RIOK2_Hsap EDSLSEESADARSFEMTEFNQA---LEEIKGQV-----VENNSVTEF-SEEKNRTENYNR CG11859_Dmel DDAVRRYIESCTQ-YLGNLS-VGPEVPDQTMPKKLDISLPAETPDVIPFEAETSATNTVE aSWK440_Cele QKIVLSQTTRFTD-WLSDA-------TNQLEAV---------DLDALKSEEGYKDIELPP RIO2_Scer ---------------------------------------------------YYDSELDN- RIOK2_Mmus DGGLPEESAHVSSFEVTALSQA---VEEMERQV-----LPHRSVTEF-SEESRRTENDG- Rio2_Ddis -NENEENIKKSSKVNK---KEVGKEIKK----------------------EEEENNNSE- 27105_Tthe QDENEEEQKNNKKQKK---HHLKKQSK-----------------------SKSKKQNQE- RIO2_Spur EDKNSEEVQSIREDDTGGMSGVGQDNDDQEHC------IMV--MDGN-EQEQSG------ CC1G_13652_Ccin EGGLS---------------------------------MPAQ--------RTYDGPSEG- AqueK050_Aque EDKLRENVSEFDSISSIPLDEIPLES-----------------------EDKDYVNN-K- RIO2-2_Smoe ------------------------------------------------------------ RIO2-1_Smoe ------------------------------------------------------------ GK011_Glam ----------------------------------------------------------M- RIOK2_Hsap QDGQRVQGGVPAG--SDEYEDECP-------------HLIALSSL-NREFR--PFRDEEN CG11859_Dmel EDV-K----SI--SSNDLDTDEVP-------------ELVGLDPN-SRMYR--LKMVEQM aSWK440_Cele EDF-K----RPADSENDDENDEDE-------------EE--GEEE-DADGH--VAVEEQV RIO2_Scer ESS-E----DDSE--DAQEEENER-------------IIEAL------------------ RIOK2_Mmus QPGQR----SPAG--SEDCDDEPP-------------HLIALSSV-NREFR--PFRDEES Rio2_Ddis EED--------EE--EEEEEDSDSE-ESVEDNTPVIEEFKGLSLNKNRDFKFSNLKDEDQ 27105_Tthe QEG--------KD--GEDDEDNQKNNFSPDLSEISIEDLKELQK-VNQDL-FS---DDDN RIO2_Spur -----------KE--KENHSDDDD-------------DLEDIGAS-NKQYR--PHRSEAS CC1G_13652_Ccin ESR-Q----KTSE--STQQEDGTP-------------DISVL------------------ AqueK050_Aque EDTLE----YISD--SEEY----------------------------------------- RIO2-2_Smoe ------------------------------------------------------------ RIO2-1_Smoe ------------------------------------------------------------ GK011_Glam V-------------------------------------------------------DDDA RIOK2_Hsap V-GAM--------------------NQYRT--RTLSITSSGS-AVSCSTIPPE------- CG11859_Dmel L-ND---------------------------AR--SQRS---YSTTTSTIAPS------- aSWK440_Cele A-KVV--------------------K-----KK--RVPS---GARSVASSAAT------- RIO2_Scer -------------------------S---------------------------------- RIOK2_Mmus M-SSV--------------------TRHRT--RTLSVTSAGS-ALSCSTIPPE------- Rio2_Ddis N-APIVLR--KEFIENL---DENQPTEPKK--EKVELTEEEK-QRRKEEKRQK------- 27105_Tthe EDDPLALNEVKDINGNIVVPEQKEKKKPKK--KMVDIANEQD-QDNKQDLKEKIYIKESE RIO2_Spur M-SKA--------------------NAHSLNARSRNSDSISSYTSTSSTMNPA------- CC1G_13652_Ccin -------------------------N--------ISRESSRS-ASP----EPD------- AqueK050_Aque -------------------------------------E-SSS-EGEETSIASK------- RIO2-2_Smoe ------------------------------------------------------------ RIO2-1_Smoe ------------------------------------------------------------ GK011_Glam DP--V-----------------DKSKEPRM--RKV------------VDIRQA------- RIOK2_Hsap ---LVKQKVKRQLT----KQQKSAVRRRL-QKGEANIFTKQRRENMQNIKSSLEAASFWG CG11859_Dmel ---VITDRIRRNMD----IKEKREQRKKCVAKGEASAVHRHRKENKDV----VKEYAGWD aSWK440_Cele ---FTAEDVKRRLALD--RKRNKEKI-RLKVKGKQSAVGRNRKDNKDV----IAEYAG-W RIO2_Scer ----------------------------------------SGVENLKM--D--KLGNYIL RIOK2_Mmus ---LVKQKVKRQLT----RQQKAAARRRL-QKGEANVFTKQRRENMQNIKSSLEAASFWG Rio2_Ddis ---MITDKVKRQL----GKTMR----EK-VS------VRNNV-KSRTK--KEVQAHI-SS 27105_Tthe LAEKAKAYIQRQV----EKQFK----QK-YK-----ILKKNT-KSSNS---NKVLAS-EY RIO2_Spur ---LVRSKVRGNLK----KKQKAAVRHRLARKGEASQTTAKRRENRDTVNQS--LGSI-W CC1G_13652_Ccin ---TVKDDIKARAAAEVSKRQNQQRRKYHSKKSVRNAGRPQGSKGKQDTRV--KLDS-FW AqueK050_Aque ---DLKKQVKKTTL----KKHHAHLKQSS-KKSQRKLPTSSGRRGQKGNRLKIRQALS-D RIO2-2_Smoe -----------------------------------------------------------D RIO2-1_Smoe -----------------------------------------------------------D GK011_Glam --------VQRQL----RKEQW----RR-IQ------HQRQS-KGTEK---HRDNYR-RD RIOK2_Hsap E CG11859_Dmel F aSWK440_Cele I RIO2_Scer E RIOK2_Mmus D Rio2_Ddis Y 27105_Tthe M RIO2_Spur S CC1G_13652_Ccin A AqueK050_Aque W RIO2-2_Smoe Q RIO2-1_Smoe Q GK011_Glam L