CLUSTAL W (1.83) multiple sequence alignment ROCK2_Hsap MSRPPPTGKMPGAPETAPG----DGAGASRQRKLEALIRDPRSPINVESLLDGLNSLVLD ROCK1_Hsap MST---------------G----D-SFETRFEKMDNLLRDPKSEVNSDCLLDGLDALVYD rok_Dmel MPAGRE---------TVTKQRSMDVERRRRANTLEREMRDPTSICNVDCLLDTVSALVSD let-502_Cele ME----------------------------QDELRDQLVDPKSPINIESLLDTITALVND ROCK1_Mmus MST---------------G----D-SFETRFEKIDNLLRDPKSEVNSDCLLDGLDALVYD ROCK2_Mmus MSRPPPTGKMPGAPETAPG----DGAGAGRQRKLEALIRDPRSPINVESLLDGLNSLVLD ROCK_Spur MS------------------------LTQRYQTLENRIKDPKCLINYEALLDSICALTRD AqueK006_Aque MAT---------------E----HSSLKARHKTLLGSLTDNKGLLHVEGLLDAVVAVYSD * : : * : : *** : :: * ROCK2_Hsap LDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQK ROCK1_Hsap LDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRK rok_Dmel CDHESLRRLKNIEQYAAKYKPLAMQINQLRMNVEDFHFIKLIGAGAFGEVQLVRHKSSSQ let-502_Cele CKIPVLMRMKSVDNFISRYERVVESLAALRMKAADFRQLKVIGRGAFGEVHLVRHTRTNT ROCK1_Mmus LDFPALRKNKNIDNFLSRYKDTINKIRDLRMKAEDYEVVKVIGRGAFGEVQLVRHKSTRK ROCK2_Mmus LDFPALRKNKNIDNFLNRYEKIVKKIRGLQMKAEDYDVVKVIGRGAFGEVQLVRHKASQK ROCK_Spur CGIPALRKSKNVENFLSRYEQKAGDITTHRLSSHDFQMIKVIGRGAFGEVKVVRERTSKK AqueK006_Aque CNYPTLHRNKNLDTFRRRYEGVVPVISNNRLSSHDFQLIKVIGRGAFGEVHLVRMKETKK * : *.:: : :*: : ::. *: :*:** ******::** : ROCK2_Hsap VYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGD ROCK1_Hsap VYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGD rok_Dmel VYAMKRLSKFEMMKRPDSAFFWEERHIMAHANSEWIVQLHFAFQDAKYLYMVMDFMPGGD let-502_Cele VYAMKMLNKDDMIKRADSAFFWEERDIMAHANSEWIVRLQYAFQDPRHLYMVMEYMPGGD ROCK1_Mmus VYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFYAFQDDRYLYMVMEYMPGGD ROCK2_Mmus VYAMKLLSKFEMIKRSDSAFFWEERDIMAFANSPWVVQLFCAFQDDRYLYMVMEYMPGGD ROCK_Spur VYAMKCLSKFEMIKRSDSAFYWEERDIMAHANSEWIVQLHYAFQDEKYLYMVMDYMPGGD AqueK006_Aque IFAMKILSKFEMIRRSDTAFFWEERDIMAHTTSEWIVQLHYAFQDSSNLYMVMDYMPGGN ::*** *.* :*::*.*:**:****.***.:.* *:*:* **** *****::****: ROCK2_Hsap LVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTC ROCK1_Hsap LVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTC rok_Dmel IVSLMGDYDIPEKWAIFYTMEVVLALDTIHNMGFVHRDVKPDNMLLDSYGHLKLADFGTC let-502_Cele LVNLMTSYEVSEKWTRFYTAEIVEALAALHSMGYIHRDVKPDNMLISISGHIKLADFGTC ROCK1_Mmus LVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTC ROCK2_Mmus LVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKHGHLKLADFGTC ROCK_Spur LVNLMSNYEIPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDSSGHLKLADFGTC AqueK006_Aque IVSLMERYEIPEEWAQFYIAELVLALEAVHSMGYVHRDVKPENMLLDGRGHLKLADFGTC :*.** *::.*:*: ** *:* ** ::*.** :******:***:. **:******** ROCK2_Hsap MKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGFYGRECDWWSVGVFLYEMLVGDTPFYA ROCK1_Hsap MKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYA rok_Dmel MRMGANGQVVSSNAVGTPDYISPEVLQSQGVDNEYGRECDWWSVGIFLYEMLFGETPFYA let-502_Cele VKMNANGVVRCSTAVGTPDYISPEVLRNQGQDAEFGKEVDWWSVGVFIYEMLVGETPFYA ROCK1_Mmus MKMNKEGMVRCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLYEMLVGDTPFYA ROCK2_Mmus MKMDETGMVHCDTAVGTPDYISPEVLKSQGGDGYYGRECDWWSVGVFLFEMLVGDTPFYA ROCK_Spur MRMERDGMVRSDTAVGTPDYISPEVLKSQAGNGQYGRECDWWSVGVFIYEMLVGDTPFYA AqueK006_Aque MKVDKNGKVRCETAVGTPDYISPEVLKSQGGDGYYGKECDWWSVGVVMFEMLCGDLPFYS ::: * * ...*************:.*. : :*:* ******:.::*** *: ***: ROCK2_Hsap DSLVGTYSKIMDHKNSLCFPEDAEISKHAKNLICAFLTDREVRLGRNGVEEIRQHPFFKN ROCK1_Hsap DSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKN rok_Dmel DSLVGTYGKIMDHKNSLSFPPEVEISEQAKALIRAFLTDRTQRLGRYGIEDIKAHPFFRN let-502_Cele EALVSTYTNIMNHKTSLKFPDEPLISTQAKDIIKKFLSAAPDRLGRNSVDDIRNHKFFVN ROCK1_Mmus DSLVGTYSKIMNHKNSLTFPDDNDISKEAKNLICAFLTDREVRLGRNGVEEIKRHLFFKN ROCK2_Mmus DSLVGTYSKIMDHKNSLCFPEDTEISKHAKNLICAFLTDREVRLGRNGVEEIKQHPFFKN ROCK_Spur DSLVGTYSKIMDHRNSLEFPDDISISGPAKDLICKFLTDRDTRLGKNGIDEIKLHRFFKN AqueK006_Aque DSLIGTYSNIMNHKNTLQFT-DVQLSANAKNIIVHFLEDASNRLGLNGVEEVKAHPFFVT ::*:.** :**:*:.:* *. : :* ** :* ** *** .::::: * ** . ROCK2_Hsap DQWHWDNIRETAAPVVPELSSDIDSSNFDDIED-DKGDVETFPIPKAFVGNQLPFIGFTY ROCK1_Hsap DQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEE-DKGEEETFPIPKAFVGNQLPFVGFTY rok_Dmel DTWSFDNIRESVPPVVPELSSDDDTRNFEDIER-DEKPEEVFPVPKGFDGNHLPFIGFTY let-502_Cele DEWTFATLREASPPVIPSLKSDDDTTHFEEIETRDRDNAGDFQLPKTFNGNQLPFIGFTY ROCK1_Mmus DQWAWETLRDTVAPVVPDLSSDIDTSNFDDLEE-DKGDEETFPIPKAFVGNQLPFVGFTY ROCK2_Mmus DQWNWDNIRETAAPVVPELSSDIDSSNFDDIED-DKGDVETFPIPKAFVGNQLPFIGFTY ROCK_Spur DMWTYDNIRNTVPPVVPELISDVDTSNFDEIEP-EDHPEESFQSPKTFAGNNLPFIGFTY AqueK006_Aque DQWNWENIRSTVAYVVPELKSEIDTAYFDDIED-TSTQPQAFSQPMEFQGNHLPFVGFTF * * : .:*.: . *:*.* *: *: *:::* * * * **:***:***: ROCK2_Hsap YRENLLLSDSPS-CRETDSIQS---------------------RKNEESQEIQKKLYTLE ROCK1_Hsap YSNRRYLSSANP-NDNRTSSN----------------------ADKSLQESLQKTIYKLE rok_Dmel TGDYQLLSSDTVDAESKEANVANSG-----AASNNHG--HG--HNHRHRPSNSNELKRLE let-502_Cele SNEYSPVKN--L-LKGHGA----------------------GSKQNGI--EQHKPQTVVE ROCK1_Mmus YSNRRYLPSANA-SENRSSSN----------------------VDKSLQESLQKTIYKLE ROCK2_Mmus FRENLLLSDSPP-CRENDAIQT---------------------RKSEESQEIQKKLYALE ROCK_Spur NKSNKLFTSVEGGVKEADGHVSAPNVGGRGGVKEADGHVSAPNVGGREYEEMKRKTHSLE AqueK006_Aque VKDSNILEGEREQVSSVE---A----------------------------TPIKPSKEIE . . . . :* ROCK2_Hsap EHLSNEMQAKEELEQKCKSVNTRLEKTAKELEEEITLRKSVESALRQLEREKALLQHKNA ROCK1_Hsap EQLHNEMQLKDEMEQKCRTSNIKLDKIMKELDEEGNQRRNLESTVSQIEKEKMLLQHRIN rok_Dmel ALLERERGRSEALEQQDAGLRQQIELITKR-------EAELQRIASEYEKDLALRQHNYK let-502_Cele QPLTNG-HASGVPEEKYEAVKMELDSKNREFE---------------------LLKDSIA ROCK1_Mmus EQLHNEMQLKDEMEQKCRTSNLKLDKIMKELDEEGNQRRNLESAVSQIEKEKMLLQHRIN ROCK2_Mmus EHLSSEVQAKEELEQKCKSINTRLEKTAKELEEEITLRKSVESTLRQLEREKALLQHKNA ROCK_Spur KQIEAEMRRNKDLDQKNKHIASKFDRIKQDLELENNDKLHLQNKLMDKEREYVQLKHKHT AqueK006_Aque EQLTLLTKQKEDLETHIKKTEEKLQRMEKENREVQASLNQVTQKYNQSEKDLGLSRIDMK : . : : .:: : : ROCK2_Hsap EYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQNSQISTEKVNQLQRQLDETNALLRT ROCK1_Hsap EYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEKLSQLQKQLEEANDLLRT rok_Dmel VAMQKVEQEIELRKKTEALLVETQRNLENEQKTRARDLNINDKVVSLEKQLLEMEQSYKT let-502_Cele RNEIRAKMIENEKNSLST------------------------KISDLERELKDNKDKLRH ROCK1_Mmus EYQRKVEQENEKRRNIENEVSTLKDQLEDLRKASQTSQLANEKLTQLQKQLEEANDLLRT ROCK2_Mmus EYQRKADHEADKKRNLENDVNSLKDQLEDLKKRNQSSQISTEKVNQLQKQLDEANALLRT ROCK_Spur ELARRAEQEQEGRKRVERQVSHITDMERELKEL----KLRSEKTTILERQVENLNKQLQT AqueK006_Aque ELTRKCEENEETISQLRARINEAESQLKG-----------AESPSKLLTEIEQLKCELKS : . : . * :: : : : ROCK2_Hsap ESDTAARLRKTQAESSKQI---QQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESE ROCK1_Hsap ESDTAVRLRKSHTEMSKSI---SQLESLNRELQERNRILENSKSQTDKDYYQLQAILEAE rok_Dmel ETENTQKLKKHNAELDFTV---KSQEEKVRDMVDMIDTLQKHKEELGQENAELQALVVQE let-502_Cele GADSDAKVNELAVELRMSKEYNSEMESE-------------------------------- ROCK1_Mmus ESDTAVRLRKSHTEMSKSI---SQLESLNRELQERNRILENSKSQADKDYYQLQAVLEAE ROCK2_Mmus ESDTAARLRKTQAESSKQI---QQLESNNRDLQDKNCLLETAKLKLEKEFINLQSALESE ROCK_Spur EGDQHARSKKMFGDHQKNY---AHLEQEISELRDKYTRELNNKMMLDQEVIRMQTQLEEE AqueK006_Aque EFQNSASLKEATQKLKQEL---LVKESVIDHLESRSKELSVERDRIDSDMITVQDELEKQ : .: . *. ROCK2_Hsap RRDRTHGSE--------------------------------------------------- ROCK1_Hsap RRDRGHDSE--------------------------------------------------- rok_Dmel KNLRSQLKE--------------------------------------------------- let-502_Cele ------------------------------------------------------------ ROCK1_Mmus RRDRGHDSE--------------------------------------------------- ROCK2_Mmus RRDRTHGSE--------------------------------------------------- ROCK_Spur QRGRSRMEDLKAELEMGGREPSMTTLEVNKEQEGSGWGGNNDKLHLQNKLMDKEREYVQL AqueK006_Aque HKLTAKLKT--------------------------------------------------- ROCK2_Hsap ------------------------------------------------------------ ROCK1_Hsap ------------------------------------------------------------ rok_Dmel ------------------------------------------------------------ let-502_Cele ------------------------------------------------------------ ROCK1_Mmus ------------------------------------------------------------ ROCK2_Mmus ------------------------------------------------------------ ROCK_Spur KHKHTELARRAEQEQEGRKRVERQVSHITDMERELKELKLRSEKTTILERQVENLNKQLQ AqueK006_Aque ------------------------------------------------------------ ROCK2_Hsap ------------------------------------------------------------ ROCK1_Hsap ------------------------------------------------------------ rok_Dmel ------------------------------------------------------------ let-502_Cele ---------------LSKFRDKCEQLKEDLRKKSGELAQEKNE----------------- ROCK1_Mmus ------------------------------------------------------------ ROCK2_Mmus ------------------------------------------------------------ ROCK_Spur TEGDQHARSKKMFGDHQKNYAHLEQEISELRDKYTRELNNKMMLDQEVIRMQTQLEEEQR AqueK006_Aque ------------------------------------------------------------ ROCK2_Hsap -------IINDLQGRICGLEEDLKNGKILLAKVELEKRQLQERFTDLEKEKSNMEIDMTY ROCK1_Hsap -------MIGDLQARITSLQEEVKHLKHNLEKVEGERKEAQDMLNHSEKEKNNLEIDLNY rok_Dmel -------MHKEAENKMQTLINDIERTMCREQKAQEDNRALLEKISDLEKAHAGLD----F let-502_Cele ------------------------------------TQRVFQQKKDA--DEAFAEIKRDY ROCK1_Mmus -------MIGDLQARITSLQEEVKHLKHNLERVEGERKEAQDMLNHSEKEKNNLEIDLNY ROCK2_Mmus -------IINDLQGRISGLEEDLKTGKALLAKVELEKRQLQEKLTDLEKEKSNMEIDMTY ROCK_Spur GRSRMEDLKAELERQNAQATQEMNRLKQGESRSIATMQNHQESIIILEKTKASLE----F AqueK006_Aque -------SNEELKKLSETQNQSISSLKSRLSEISDENQRIKRSQAESEKDKTSLEL---- : . : ROCK2_Hsap QLKVIQQSLEQEEAEHKAT-KARLADKNKIYESIEEAKSEAMKEMEKKLLEERT--LKQK ROCK1_Hsap KLKSLQQRLEQEVNEHKVT-KARLTDKH---QSIEEAKSVAMCEMEKKLKEERE--AREK rok_Dmel ELKAAQGRYQQEVKAHQETEKSRLVSR-------EEANLQEVKALQSKLNEEKS--ARIK let-502_Cele EL--LQTR-----------------------------ENEKSVQLKKALDERKENGAYQQ ROCK1_Mmus KLKSIQQRLEQEVNEHKVT-KARLTDKH---QSIEEAKSVAMCEMEKKLKEERE--AREK ROCK2_Mmus QLKVIQQSLEQEEAEHKTT-KARLADKNKIYESIEEAKSEAMKEMEKKLLEERS--LKQK ROCK_Spur DLKALQNTHEQGVKEHRDA-MAAVNAEK---KRITRT---QEDELQKTLVQERE--MR-- AqueK006_Aque NLKSLQQRYDQMSKSHEQL-SVQFKSTS---TSVEES----VSQLRSQLDSEVS--ARQT .* * :.. * .. ROCK2_Hsap V--ENLLLEAEKRCSLLDCDLKQSQQKINELLKQKDVLNEDVRNLTLKIEQETQKRCLTQ ROCK1_Hsap A--ENRVVQIEKQCSMLDVDLKQSQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQ rok_Dmel A--DQHSQEKERQLSMLSVDYRQIQLRLQKLEGECRQESEKVAALQSQLDQEHSKRNALL let-502_Cele SVAKATDAEWERKMQFYEK-------QLEHA--NDE------------RKREEQKRTAAE ROCK1_Mmus A--ENRVVETEKQCSMLDVDLKQSQQKLEHLTENKERMEDEVKNLALQLEQESNKRLLLQ ROCK2_Mmus V--ENLLLEAEKRCSILDCDLKQSQQKLNELLKQKDVLNEDVRNLTLKIEQETQKRCLMQ ROCK_Spur -------VQVDKQNSILELDLKQAQQKIERMENMIKMEEQKTKEKMLQLEQEEQRHRFTQ AqueK006_Aque A--ERTASDLEHQTSFLRLDLKQTNEEVSDLKQQIHDLEES-------LRQEKRLREREE : ::: .: .:. :* : ROCK2_Hsap NDLKMQTQQ-VNTLKMSEKQLKQENNHLMEMKMNLEKQNAELRKERQDADGQMKELQDQL ROCK1_Hsap NELKTQAFE-ADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQL rok_Dmel SELSLHSSE-VAHLRSRENQLQKELSTQREAKRRFEEDLTQLKSTHHEALANNRELQAQL let-502_Cele FDQSRVAR-KLAGIEANYELLQNDYKSMKEARKDLERDLQDVITEKRRLEIRVEQLMDSR ROCK1_Mmus NELKTQAFE-ADNLKGLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQL ROCK2_Mmus NDLKMQTQQ-VNTLKMSEKQIKQENNHLMEMKMNLEKQNTELRKERQDADGQMKELQDQL ROCK_Spur NDLKASKQT-SSGYQTDIKRLRNELNTIKEQGKNFEEALEKSKSIASLNGSQISDLQEQL AqueK006_Aque AEAKKQQKELTDRLAGREQDIRAQLQELKNEKQKMEDTIYRLKSEGKAADASLKETLEEL : . : :: : . : :* . : . ROCK2_Hsap EAEQYFSTLYKTQVRELKEECEEKTKLGKELQQKKQELQDERDSLAAQLE-ITLTKADSE ROCK1_Hsap EAEQYFSTLYKTQVKELKEEIEEKNR---ENLKKIQELQNEKETLATQLD-LAETKAESE rok_Dmel EAEQCFSRLYKTQANENREESAER-------LSKIEDLEEERVSLKHQVQ-VAVARADSE let-502_Cele NTDERVLSLCQDELVESQEEAKYK-----------------EDGLRGKID-GFKHELENE ROCK1_Mmus EAEQYFSTLYKTQVKELKEEIEEKNR---ENLRKIQELQSEKETLSTQLD-LAETKAESE ROCK2_Mmus EAEQYFSTLYKTQVRELKEENEEKTKLCKELQQKKQDLQDERDSLAAQLE-ITLTKADSE ROCK_Spur EAEHTFNALYKSQNQVLSEELMESKQEYQQLQQDYHQLSNEKESLAAQLE-LTLTKADSE AqueK006_Aque EQERKLTNSLRGRINNMGEAGVN--------EKEITRLKSENSELNSKLENVTQIK---- : :. . : . * . * ::: . ROCK2_Hsap QLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDATIASLEETNRTLTSDVANL ROCK1_Hsap QLARGLLEEQYFELTQ-------ESKKAASRNRQEITDKDHTVSRLEEANSMLTKDIEIL rok_Dmel ALARSIAEETVADLEKEKTIKELELKDFVMKHRNEINAKEAALATLKEAENELHKKLGQK let-502_Cele KMKTQTLEENLLVADKERGMLKMEVQELMQRHKWEITNKDQTLKHLETQLDEIKQ----- ROCK1_Mmus QLARGILEEQYFELTQ-------ESKKAASRNRQEITDKDHTVSRLEETNSVLTKDIEML ROCK2_Mmus QLARSIAEEQYSDLEKEKIMKELEIKEMMARHKQELTEKDTTIASLEETNRTLTSDVANL ROCK_Spur QLARTIAEDQYTDLEREKTMVELEYKEQIQRHKCTLNDKNSHLNKLEDDKTQLNNRIMTL AqueK006_Aque ----AAAEAKLADFEREKMMIELDIKEIIARHKTEVTERMAWSSKMKDQLIIMENKLNQK * : : :. ::: :. : :: : . ROCK2_Hsap ANEKEELNNKLKDVQEQLSRL---KDEEISAAAIKAQFEKQLLTERTLKTQAVNKLAEIM ROCK1_Hsap RRENEELTEKMKKAEEEYKLE---KEEEIS--NLKAAFEKNINTERTLKTQAVNKLAEIM rok_Dmel AAEYEDLVQQHKKQQEELALMRSSKDEEIT--K----LLDKCKNEVLLKQVAVNKLAEVM let-502_Cele ----------------QSKIES-S-EQESNDKQTIADLRKKLDLEKAHKKAVINKLEEEM ROCK1_Mmus RKENEELNERMRTAEEEYKLK---KEEEIN--NLKAAFEKNISTERTLKTQAVNKLAEIM ROCK2_Mmus ANEKEELNNKLKDSQEQLSKL---KDEEMSAAAIKAQFEKQLLNERTLKTQAVNKLAEIM ROCK_Spur NTEKDELNKKLKESSEAQEAME-TKHQEME--KQMEQNKKLLGEEKLKKEQAVSKLAEIM AqueK006_Aque NLENEQLQDNLKRALIRLDDYQTF-DETR-DDEI-KKMSKQLETEKMMKKEAINKLTRIM .: . * * .:.** . * ROCK2_Hsap NRKEP---V---KRGNDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIA ROCK1_Hsap NRKDFKIDR---KKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLV rok_Dmel NRRDSDLPKQKNKARSTAELRKKEKEMRRLQQELSQERDKFNQLLLKHQ----DLQQLCA let-502_Cele AKRQPL--KKGEKGVTKSALIKKEREIMALEQERDTMSKRIAALFYENDKQAEHFNIAIQ ROCK1_Mmus NRKDFKIDR---KKANTQDLRKKEKENRKLQLELNQEREKFNQMVVKHQKELNDMQAQLV ROCK2_Mmus NRKEP---V---KRGSDTDVRRKEKENRKLHMELKSEREKLTQQMIKYQKELNEMQAQIA ROCK_Spur NRKDFNPSSRKGKKVSQAAMNQKEKECRKLQQQLNQERDKYSQMVIKFTKEKEELTVQYT AqueK006_Aque LERKSL-PS-NVKKP--EPRRAHEREIRKLRGELQQETQKYKRVVEKYQQQLEEIQRQIQ .:. * :*:* *. : . .: . : .: ROCK2_Hsap EESQIRIELQMTLDSKDSDIEQLRSQLQALHIG---LDSSSIGSGPGDAEADDGF---PE ROCK1_Hsap EECAHRNELQMQLASKESDIEQLRAKLLDLS------DSTSVASFPSADETDGNL---PE rok_Dmel EEQQLKQKMVMEIDCKATEIENLQSKLNETA------SLSSADNDPEDSQHSSLLSLTQD let-502_Cele -------DMQTTQDALRDELKECKEELANRNVNTRYEDKRSLDSREGIPSSL---SN-QH ROCK1_Mmus EECTHRNELQMQLASKESDIEQLRAKLLDLS------DSTSVASFPSADETDGNL---PE ROCK2_Mmus EESQIRIELQMTLDSKDSDIEQLRSQLQALHIG---MDSSSIGSGPGDAEPDDGF---PE ROCK_Spur EEYSKHCELQLELDSRDSELEQLQQQIKNLTAMH-ASDSASINSA---GEAE-NG---QG AqueK006_Aque EETQMRLELQHQLHTSEGKLQQLQQGIG-----------SYVSNGPSTETHDGAS---AI .: .::: : : . ROCK2_Hsap SRLEGW-LSLPVR-NNTKK-FGWVKKYVIVS--SKKILFYDSEQDKEQ-SNPYMVLDIDK ROCK1_Hsap SRIEGW-LSVPNR-GNIKR-YGWKKQYVVVS--SKKILFYNDEQDKEQ-SNPSMVLDIDK rok_Dmel SVFEGW-LSVPNK-QNRRRGHGWKRQYVIVS--SRKIIFYNSDIDKHNTTDAVLILDLSK let-502_Cele IQMEGW-LSLRDNTKKSRK-PKWTNCFVALN--EYSFTIYVDE---KAV-SVILLIEAGA ROCK1_Mmus SRIEGW-LSVPNR-GNIKR-YGWKKQYVVVS--SKKILFYNDEQDKEQ-SSPSMVLDIDK ROCK2_Mmus SRLEGW-LSLPVR-NNTKK-FGWVKKYVIVS--SKKILFYDSEQDKEQ-SNPYMVLDIDK ROCK_Spur GRLEGW-LSLPGK--NLRR-HGWKKHFVEVS--SKKILFYESEDQKAQ-KKPYLVLAIDK AqueK006_Aque YQRETLLVQVPKG-NNARK-NGWKDVFLVLSFTNKKLLIYDRPEDMGTDIPPSFTLELSQ * :.: : :: * :: :. . .: :* : : . ROCK2_Hsap LFHVRPVTQTDVYR--ADAKEIPRIFQILYANEGESKK-EQEFP-VEPV--------GEK ROCK1_Hsap LFHVRPVTQGDVYR--AETEEIPKIFQILYANEGECRK-DVEME-PVQQ--------AEK rok_Dmel VYHVRSVTQGDVIR--ADAKEIPRIFQLLYAGEGASHR-PDEQS-QLDVSVLHGNCNEER let-502_Cele MAHVRHVTAADLRN--VDDSQLPKIFHIMYDDASCNSSRHASNS-DLSM--------IES ROCK1_Mmus LFHVRPVTQGDVYR--AETEEIPKIFQILYANEGECRK-DIEVE-PVQQ--------GEK ROCK2_Mmus LFHVRPVTQTDVYR--ADAKEIPRIFQILYANEGESKK-EPEFP-VEPV--------GEK ROCK_Spur LFHVRAVTQGDVIR--AEARDIPRIFQLLYAGEGENRR-MVPDEANENP------GQDDE AqueK006_Aque VYSVRSLTQGEHERVRIKPNDSKRVLQVAYVDQQSEQS-IIAHPP----------VE--- : ** :* : . . : ::::: * . ROCK2_Hsap SNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEII ROCK1_Hsap TNFQNHKGHEFIPTLYHFPANCDACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLI rok_Dmel PGTIVHKGHEFVHITYHMPTACEVCPKPLWHMFKPPAAYECKRCRNKIHKEHVDKH-DPL let-502_Cele FREESWKRHDFQELSYHIRTFCDVCNKKLSDIIRPTPAFECKNCHFKTHKDHVAQG-S-L ROCK1_Mmus TNFQNHKGHEFIPTLYHFPANCEACAKPLWHVFKPPPALECRRCHVKCHRDHLDKKEDLI ROCK2_Mmus SNYICHKGHEFIPTLYHFPTNCEACMKPLWHMFKPPPALECRRCHIKCHKDHMDKKEEII ROCK_Spur EGTIVHKNHKFTVVHFHMPTTCECCSKTLSHLVRPPPALECKLCRLKVHKEHYDKQEEFC AqueK006_Aque -GEVHVRGHHFVESRNSSRSSCDVCGKTLPLALLSGGILECKHCQMKCHKDDVDKT-DLI : *.* : *: * * * . . **: *: * *::. : . ROCK2_Hsap APCKVYYDISTAKNLLLLANSTEEQQKWVSRLVK--KIPKKPPAPDP------------- ROCK1_Hsap CPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVK--KIPKNPPS--G------------- rok_Dmel APCKLNHDPRSARDMLLLAATPEDQSLWVARLLK--RIQKSGYKAAS------------- let-502_Cele PMCR--YNTGLSRELVLMAPQTDNCNKWVSQLRR--FIESSRSAAVS------------- ROCK1_Mmus SPCKVSYDVTSARDMLLLACSQDEQKKWVTHLVK--KIPKNPPS--G------------- ROCK2_Mmus APCKVYYDISSAKNLLLLANSTEEQQKWVSRLVK--KIPKKPPAPDP------------- ROCK_Spur PPCKVNIDAETAKHMLLMANSKEEQQRWIGKLGK--QIQDKRVSL--------------- AqueK006_Aque RPCVAG--EQDQKKLLLLIKSDDDRSRWLSMLQAGEVVPSNKSPSASSNSLVPAGVNTKR * :.::*: :: . *: * : .. ROCK2_Hsap ----------------FARSSPRT-SMKIQQNQSIRR----------------------- ROCK1_Hsap ----------------FVRASPRTLSTRSTANQSFRK----------------------- rok_Dmel ----------------YNNNST--DGSKISPSQSTRSSYKPYA----------------- let-502_Cele ----------------VSRVSSR------------RHAP--------------------- ROCK1_Mmus ----------------FVRASPRTLSTRSTANQSFRK----------------------- ROCK2_Mmus ----------------FARSSPRT-SMKIQQNQSIRR----------------------- ROCK_Spur ---------------------PRTSS-----INSP-R----------------------- AqueK006_Aque DRTNSLRFNKRPTSAQHGRGSPSGSSNRTYSVSTQRQRSTDVGGVGGGAANYGTVPGPGG . ROCK2_Hsap -----------PSRQLAPNKPS ROCK1_Hsap -----------VVKN-TSGKTS rok_Dmel ------VNVQRSATLPANSSLK let-502_Cele ------------GSSNSSTIYQ ROCK1_Mmus -----------VVKN-TSGKTS ROCK2_Mmus -----------PSRQLAPNKPS ROCK_Spur -----------YIRA-VEGTNP AqueK006_Aque IGMRQIEFVRSNDSDTNPPQSQ