CLUSTAL W (1.83) multiple sequence alignment BCK1_Scer MPFLRKIA----G--TAHT----------------------------------------- SSK2_Scer MSHSDYFNYKPYGDS----------T-----------------------EKPS--SSKM- SSK22_Scer MMMDILNTQQQKAAEG-------GRV-----------------------LAPHTISSKLV STE11_Scer MEQTQTAEGTDLLIGDEKTND---LPFV---------------Q---------------- 6622_Tthe MSMFDKEYDKK-GFD--------I-------------------------KQIQSPILKL- 7147_Tthe MGCGASNHKGEVA-------------------------------------EPRS------ 11359_Tthe MGICGAKMKI-VA-------------------------------------EPVQ------ 15684_Tthe MGSSFSNSCAKSK-------------------------------------QK-K------ 18758_Tthe MKNQEFNNSAQKSS------------------------------------TYKLPIKKN- 23105_Tthe MRTYKFIIDQKIDEN--------L-------------------------KVLKKEEAKL- 29763_Tthe MGNNLLNACKNTS-------------------------------------APTD------ MEKKalpha_Ddis MSWLNNPSQ-NF-VD----------P---------------------------------- CC1G_12014_Ccin MGSVDLRGQLPFPTGPTISLD---PPPGTTFAESLKAWTDNHVA---------------- CC1G_10524_Ccin MDSRPASTLRT-L----------------------------------------------- CC1G_13687_Ccin MRKHNPTLYTLSERDSDDINDDDENV-----------------SWQHEEHDPV-PGPS-- CC1G_10513_Ccin MSEDVRNGKIH-G--RKYF-V--------------------------------------- GK078_Glam MGVGASSVPGNATSEHIDGS---------------------------------------- * BCK1_Scer ------------------------------------------------------------ SSK2_Scer RQSSSSSSSR-LRSESLGRNSNTTQARVASSPISPGLHSTQYFRSP-------------- SSK22_Scer KRLSSHSSHKLSRSDLKA------------------------------------------ STE11_Scer --------------------------LFLEE-IGCTQYLDSFIQCNLVT----------- 6622_Tthe YQN--------------------------------------------------------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe SMGS-------------------T--------IGCWI--SSAKRKNFLFT---------- 23105_Tthe HQGN-------------------N-------KISLIV--NNH-IQQFEIKATLPFSNRSN 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis -----------------------------------------FIRIKCIL----------- CC1G_12014_Ccin --------------------------RWLSD-MKCGMHAEVF-RINDIR----------- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin NVSASSNLNRSVRSSLKGRQSS-------------------------------------- CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer -------------------------------------------------------NAV-- SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------EEEIKYL---------------DK 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------------------------------------------------------------ 11359_Tthe ---------------------------------------------TGKT--PE------- 15684_Tthe ---------------------------------------------EN----KS------- 18758_Tthe ----------------------------------------REIPFSEDT--PNQMNK--- 23105_Tthe FKPPLYRGNAHLLVANGKKNHSLSIHHPHHFHLNNNGNHLKVIPTTNKK--PKNLNSN-- 29763_Tthe ---------------------------------------------QND---GD------- MEKKalpha_Ddis ------------------------------------GDDIRIIKFNSNISYGGLMNQLEQ CC1G_12014_Ccin ------------------------------------GDVLLEL---------------DQ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------A---------------NR GK078_Glam ------------------------------------------------------------ BCK1_Scer --HSRSDSNS-------------------------------------------------- SSK2_Scer --------YS----PGE------------------------------------SPLNTVQ SSK22_Scer ------------------------------------------------------------ STE11_Scer DILIALGVNK----IGDRL----------------------------------KILRKSK 6622_Tthe -AKQEINNKS-----D-NIFSPSLNSQNIQSS--------------------KKIY--QH 7147_Tthe -----------------RFIFL--NA--------------------------------IQ 11359_Tthe ------------------------NN--------------------------------RQ 15684_Tthe -----------------NMISP--EQ--------------------------------MQ 18758_Tthe --------IE-----G-KKTIF--NR--------------------------KTT---IQ 23105_Tthe -NNNSINNIS-----I-NH--SNSNSINLQSNIPNSFHRPQSPVVLNISSDRHNLY--QQ 29763_Tthe -----------------NDQT----Q--------------------------------KE MEKKalpha_Ddis DFQCPISIHQYEDYEGDKVTVK--SKDDIMEALTMYFE--------------LKALNPTK CC1G_12014_Ccin DTLKEMNIVS----IGDRI----------------------------------RILNAVK CC1G_10524_Ccin QT--------------W------------------------------------------- CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin GSDSENDSDD----DNDKP----------------------------------PIFNSYH GK078_Glam ------------------------------------------------------------ BCK1_Scer -------------------------------SVKFG--HQPTSS---------------- SSK2_Scer LFNRL--------------------PGIPQGQFFHQ--NA-------------------- SSK22_Scer ------------------------------------------------------------ STE11_Scer SFQRDKRIEQVNRLKN-------------------------------------------- 6622_Tthe QL-QPLQLV--------------------------------------QKDDQK------- 7147_Tthe QF-QQFRLE--------------------------------------QKENQV------- 11359_Tthe KK-QKQ------------------------------------------------------ 15684_Tthe NK-ESSNLT--------------------------------------QKLDN-------- 18758_Tthe QK--QNQLQQ-Q-----------------------------------QVQQQT------- 23105_Tthe QQ-QQYSFQH-------------------------------------QAHNQI------- 29763_Tthe KQ-EKRKLE--------------------------------------RKKNQR------- MEKKalpha_Ddis IISTKFFLKQ-LPPQ-----------------------SQPLSSSLSPTQSLILNNNNNN CC1G_12014_Ccin LLRQRAAARTPSPIHV----------------------TRPTAS---------------H CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin YSAPYHSKPPPTDPYDHHPPALRTDLGS---SYVQDHNHRPSLS---------------- GK078_Glam ------------------------------------------------------------ BCK1_Scer --------------VASTKSSSKSPRATSR----------KS------------------ SSK2_Scer --------------ISGSSS-SSARSSRRPSNIGLPLPKNPQQSLPKLSTQPVPVHKKVE SSK22_Scer --------------LGGSET-I----S--------------------------------- STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis SNNNLMNMNMNMNLNMN-SNNSSGSSSSNN--IVI--PQQQG------------------ CC1G_12014_Ccin TRTGS--ENLSLEQGVASGRGHSRKESTRP--PPI--TIHPN------------------ CC1G_10524_Ccin --------------------AVPFRETVP------------------------------- CC1G_13687_Ccin -------------------------HS--------------------------------- CC1G_10513_Ccin --------------SPSSLSSHAADESTPP----------PP------------------ GK078_Glam ---------------------------------LLPVPQLERDKL--------------- BCK1_Scer IYD--DIR---------------S-----------------------QFPN--------- SSK2_Scer ASKT--ESEIIKKPAPVNSNQDPLLTTPTLVISPELASLNTTNTSIMSTPQNITNQTSNK SSK22_Scer -----------------------------------------------DGPSQL------- STE11_Scer ---------LMEKV---------------------------------------------- 6622_Tthe --------EHKKKPQ------------------------------------SIQ------ 7147_Tthe --------QKNK------------------------------------------------ 11359_Tthe ------------RQN------------------------------------NI------- 15684_Tthe --------NIQD-MN------------------------------------T-------- 18758_Tthe ---------IQN-SN--------------------------------------------- 23105_Tthe ------------------------------------------------------------ 29763_Tthe --------NKSD-FG------------------------------------S-------- MEKKalpha_Ddis NRKGSNAPP-LRTPPPSPPSS--------------------------------------- CC1G_12014_Ccin ANKG-DLPDLIREPPPDSASGRSM-----------------------MAP---------- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin -----------------------------------------------KVPTNVN------ CC1G_10513_Ccin TPGV-SLP---------------L-----------------------ASPP--------- GK078_Glam ------------------------------------------------------------ BCK1_Scer ---------------------------------------LTPNSTSSQFYESTPVIEQSF SSK2_Scer HIPTRSQPNGSTSSSTLQDIVTTNSSQRSVGHHGGSTTSLRTYKKQYVLNEQLYLRKMRN SSK22_Scer -----------------------------------------TFKDRYVFNESLYLKKLKK STE11_Scer ------------------------------------------------------------ 6622_Tthe ---------------SSDR----------------------------------------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------SPKNS- CC1G_12014_Ccin -------------------------------------------PPVR----PLPVPQNAT CC1G_10524_Ccin -----------------------------------------------------PVP---- CC1G_13687_Ccin ---------------TKQDIY-------------------SQFVKRYRTKEHRYVDEMED CC1G_10513_Ccin ---------------------------------------TIPAKPVHPLHEALPINDRHY GK078_Glam ------------------------------------------------------------ BCK1_Scer ---NWTTDDHISA-G-TLENP-TSFTNSSYKNDNGP------------------------ SSK2_Scer ---RAND-DYYTRGIV-ASSN--------FEDDE--E----------------------- SSK22_Scer ---TALD-DYYTRGIK-LTNR--------YEEDDGDD----------------------- STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin ---PTASQ-VSTPEP-GITHAL-----KRIYMGFTLQTLQINVSVAAASGPARRLGGHPY CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin FRSDPDS-HYYHKGLGQLVDV--------GDASDDED----------------------- CC1G_10513_Ccin ---PDVH-QTSARGG-TVTNMLTNL--RNWRHGSTPRT---------------------- GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------SSLSD------------SRKSSGG SSK2_Scer -------------------------------------NFSNKGEDDLELEMDDLLKVE-G SSK22_Scer -------------------------------------EIIRLS--------------N-G STE11_Scer ----------------------------------SSLST--------------ATLSMNS 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin AMPSVQATLHPPTGLQNPNLSPIDEHFAAAGQNSSSTSTPSPPSQPYRSYTPAN----AY CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin -------------------------------------YMSLIG--------------G-N CC1G_10513_Ccin ---------------------PVEASAARRPRTSPSVSTPD------------SAVSSNS GK078_Glam -------------------------------------------------------GL--- BCK1_Scer NSVN-------------------------SL-------------S--------------- SSK2_Scer EDKDNDFNFGYNFITSSTKNNENVVSMSLNYLKGKLDWLRDVNNDQPCEIEDEEWHSILG SSK22_Scer DRIDEDLHSGVKFFSTTPYC-------------------RKMRSD--------------- STE11_Scer E----------------------------LI-------------P--------------- 6622_Tthe --ILSKDYSKGKIF----------------------------QIQ--------------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin NTPS------------------------LDD-------------I--------------- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin DGIIEG--------------------------------------S--------------- CC1G_10513_Ccin N----------------------------LP-------------N--------------- GK078_Glam ------------------------------------------------------------ BCK1_Scer -FD---KLILS-W-DPTDPDEWTMHRVTSWFKFH----DFPESWIL-FF--------KKH SSK2_Scer SEDLLSKLL--Q--NPMVN----------------------------------------- SSK22_Scer -SD---ELA--W--NEIAT----------------------------------------- STE11_Scer -EK---HCVIFI-LNDGSA---KKVNVNGCFNADSIKKRLIRRLPH-ELLATNSNGEV-- 6622_Tthe -KD---EM---------------------------------------------------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin -RK---KIVKFVIPEEGTS---YMIDVTNCSSGQEVIEKVLKKIGKGGFRGIDNDGHGD- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin -MD---EMAHPV--TEKDQ----------------------------------------- CC1G_10513_Ccin -PD---KILICVT-TEADPERLNIVDVSGAKDATSIRESILSKVPY-SFSAVSSSILTRH GK078_Glam ------------------------------------------------------------ BCK1_Scer QLFGHRFIKLLAYDNFAVYEKYLPQTKTASYTRFQQLLKKTMTKNVTNSH---------- SSK2_Scer -----------------------------NRFEWQTMLSKVLKGDIVRNEKTKIANQGKG SSK22_Scer -----------------------------ERFKWQSMLARVLKGDIVKGEKTRIANQVKK STE11_Scer ---------TKMVQDYD------------------------------------------- 6622_Tthe ----------------------------------------------------------SG 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ----------------------------------------------------------HN 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin -----RDDGSLNVDGWA------------------------------------------- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin -----------------------------RRLEWQSLLSSVLSGEVLKSEKTRLAVALDS CC1G_10513_Ccin -----QTNLLDGLNRYS------------------------------------------- GK078_Glam ------------------------------------------------------E----- BCK1_Scer ---------I------------------------------------------RQKSA-SK SSK2_Scer PGFN-TQFSD------------------------------------------DIWIE-LK SSK22_Scer PGLN-KELSD------------------------------------------EIWLE-LK STE11_Scer ---------V------------------------------------------F--VLDYT 6622_Tthe FA--INNFNNNN-KL----------------SAFQSYPQSPTYKDQFNC-KLQ------- 7147_Tthe ----------------------------------------------------K------- 11359_Tthe --------NQ------------------------------------------Q------- 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe NS--NNNNNNNNNNTNNNCNNVGLGGNFGQLGFMRDRPQR---KNRHNSIKLI------- 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin ---------V------------------------------------------Y--LASGE CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin FGDEQNNFNM------------------------------------------NIWLG-IR CC1G_10513_Ccin ---------I------------------------------------------Y--LTEIG GK078_Glam ------------------------------------------------------------ BCK1_Scer LKSSRSSSES-----IKSKLKNSKSQ------EDISNSRSTSESAL-------------- SSK2_Scer AWMNGRTVED-----QNKSLRIFRD-STDSVFQEIMAFKLEDN--M-------------- SSK22_Scer AWLNGRTMQE-----MEQSLTYLRD-SSDSVFEEIMKFQIPQGKIL-------------- STE11_Scer -KNVLHLLYDVELVTICHA----------------------------------------- 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin -ESPSEPLTETQLLNICNA----------------------------------------- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin AKFHGRSIEE-----EKRKLDEKRIRIVDGVIDEIMNFRVVQDEAA-------------- CC1G_10513_Ccin ASVIGDPLNDERLLDLVQRQGDSRGT------LKFFVSRSTKEQIPPPPQQMPPPFPFPY GK078_Glam ------------------------------------------------------------ BCK1_Scer --SPTK----------------------S----------GPSKTDE----------KNFL SSK2_Scer ---SADEAAETIKSLVDKYYRVLNLWPNI-----KRMHAEKPITKT----------EAFR SSK22_Scer ---SLDALEAILQDLMNRYHSVVSYWPNL-----KKMYKDKPITNT----------AEFT STE11_Scer ---NDR----------------------VEKNR--------------------------- 6622_Tthe --------SKQSEET-------------------------------------PTQK---- 7147_Tthe --------NKQSEDV-------------------------------------V------- 11359_Tthe --------NKLGEE---------------------------------------------- 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe --------KQKAEHS-------------------------------------VSSK---- 29763_Tthe ---------VHAEDI-------------------------------------IEKK---- MEKKalpha_Ddis --------------------------------------------------------PPFL CC1G_12014_Ccin ---PDH----------------------PARERGLAVRRLRRQEDRSGSPLA-------- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ---PTNSAMKQVTNILHRLDVAQSLYPHL-----KAFYLDKPKAQE----------GPFQ CC1G_10513_Ccin VEQPTH----------------------PA---ILPLRPRRRPRSRQGSVSSVSSEQPAE GK078_Glam ------------------------------------------------------------ BCK1_Scer -------HSTSTHQKTKSASSLYRRSFISLRGSSS-SNASSAKSPSNIKLSIP-ARPHSI SSK2_Scer N-------RIDTLNSWLNFKFNFDTNIAYLKKWIVGNKELES------------------ SSK22_Scer A-------RIDVMNSWLNFKTNLTLRRQELDDWINRFSPIS------------------- STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis -------GNNS-------NTSINILDFYSLNGSNN-NSGGTG------------------ CC1G_12014_Ccin ----RNLQPPT-QPTSKATKRASSISILSGLGVRN------------------------- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin A-------RCDALNTWFTILSSLKRHLTRLRRWTGSDS-LDV------------------ CC1G_10513_Ccin LGYDADLDNPDDSRKSSRQQNHSSRSHLTGPGISP-PSPGPLRRPPNGPLPIAPLGPPSA GK078_Glam ------------------------------------------------------------ BCK1_Scer IES-----NSTLT--KSASPPASPS-YPSI-FRRHHKSSSSESSLLNSLFGSGIGEEAPT SSK2_Scer ---TTEVDNTTVNL-DDPAV-FAT-NCKRF-AEQIMKEKDIEL----------------- SSK22_Scer -----SSDNCQEDF-DGVPQ-WNC-KMKIL-AEQLMKEKNIES----------------- STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ---------------------------------------Q-------------------- 23105_Tthe ---------------------------------------Q-------------------- 29763_Tthe ---------------------------------------E-------------------- MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ---NHPNPNSEITVTSQGSV-EHP-DGTSF-VERLLKEESMQR----------------- CC1G_10513_Ccin SHSNYPHPPSPI---SQGHV-SKPPTPPTFFHDRPHLPSASRSTYI-------------- GK078_Glam ------------------------------------------------------------ BCK1_Scer KPNPQGHSLSSENLAKGKSKHYETNVSSPLKQSSLPTSDDKGNLWNKF----------KR SSK2_Scer -IFQKKI-FFPLAPWILKAKFFFLKYQKTWNELNLSYLDQDLEFLLMFPMRLVKDIILIR SSK22_Scer -IFQKKI-FYPLSPWMFKLKLHFIVYRETLTKMNIKYPYERLRSLLAFPVYLIKEVILTR STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin -TFEKGF-LVTVHAFLGTVRDAHVNLAAQLKEMNLPTFENELVPLISFPTKLAQASLRLR CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer KSQIGVPSPNTVAYVTSQETPSLKSNSS-TATLTVQTAD--V-------NIPSPS---SS SSK2_Scer LSYAKKIQN-PTLMMIDQMMDDFSTYIKLAVQMKFTVAS--Y-------CN-----DWFF SSK22_Scer LSYARKLKN-PTMMMIDQMIDDFNAFIRLSVQLKYTLTK--Y-------CS-----NLPF STE11_Scer ------------------------------------------------------------ 6622_Tthe ---------------------------------SQNQPLYRLPN--N------------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------P----------------- 18758_Tthe -----------------------------GASLSVLQSG--Q-------ALPKL------ 23105_Tthe -----------------------------ISSINILQSH--NPNYQKHNIIPSLIESPIT 29763_Tthe -----------------------------I------------PR---------------- MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin -------------------------------------PD--K-------VLGD------- CC1G_10524_Ccin -----------------------------------DLPG--R-------LLPQP------ CC1G_13687_Ccin LDYVGKLEPDVDVLIIDQMTEDLKLNIGLACTLKRQYQA--F-------LAPDPDGNWAL CC1G_10513_Ccin -----------------------------------DKYG--Q-------VLPAPP---P- GK078_Glam ------------------------------------------------------------ BCK1_Scer PPPIPKTANR-------------------------------SLEVISTEDTPKISSTTAS SSK2_Scer KVKID------------------------------------------------------- SSK22_Scer DVDFD------------------------------------------------------- STE11_Scer ------------------------------------------------------------ 6622_Tthe --------------------------EANPF-------K---DG---------------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe KSSHNHNNHSNINGNFSSNDHTSDLDKANNS----SNTN---NGT---ISNINI------ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ---SSSPHNS-------------------------------------------------- CC1G_13687_Ccin PPCIS------------------------------------------------------- CC1G_10513_Ccin PPPLSSPRRGDF------------LDEPNSSLSPLAHIRSGS------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer FKETYPDCINPDKTVPVPVNNQKYSVKNFLLDQKFYPLKKTGLNDSENKYILVTKDNVSF SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer -------------------------------------------------LIFVSKDQT-- 6622_Tthe -----------------------------------------------NQ-LQIQNDNIKA 7147_Tthe ----------------------------------------------------IQ-----D 11359_Tthe --------------------------------------------------LNNSKKDE-- 15684_Tthe ------------------------------------------------------------ 18758_Tthe ---------------------------------------------------KIQNDS--- 23105_Tthe -----------------------------------------------SN-IQIMNNSSSN 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis --------------------------------------------SNNNGIGSSSREIT-- CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin -----------------------------------------DAGAEREQ-LLIASEQAEA GK078_Glam ------------------------------------------------------------ BCK1_Scer VP-LNLKSVAKLSSFKESALTKLGINHKNVTFHMTDFDCDIGAAIPDDTLEFL------- SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ---------------------------------------------PSDK----------- 6622_Tthe IKLE----------------------------------------SDQK------------ 7147_Tthe LDAQ----------------------------------------EDIRT----------- 11359_Tthe ---------------------------------------------KAHK----------- 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe NNTN----------------------------------------SNQN------------ 29763_Tthe ---Q----------------------------------------EEQSD----------- MEKKalpha_Ddis ---------------------------------------------PPLR----------- CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin A--------SQQRRRRDASLTRLRA------------------EPSRDNLSLLSRNRKPT GK078_Glam ------------------------------------------------------------ BCK1_Scer -----------------------KKSL--------------------------------- SSK2_Scer ------------PEFDHTVVEGLEYFFSILELRILYSGKNSFKTSKEPDLLLKYWEMFRN SSK22_Scer ------------PTFENTVIEAIRYLFFLLNLKLIDSSKQNF---KAPDLLLKYWDHLKN STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------SISQ----------------LQSP------------------ 7147_Tthe ------------------VVSQ----------------LKE------------------- 11359_Tthe ------------------IQSS----------------QKN------------------- 15684_Tthe ------------------------------------------------------------ 18758_Tthe ---------------------V----------------NNAA------------------ 23105_Tthe ------------------GNSS----------------SQNY------------------ 29763_Tthe --------------------SS----------------SQQM------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ------------EDYDSTILEALTQFFKLLHWKLKSGVKGIY--LKETDVLEAQWATYND CC1G_10513_Ccin PTDPNDWTFINPPDTNIPVTEPLRSGEPIWPTKTLASS---------------------- GK078_Glam ------------------------------------------------------------ BCK1_Scer ----------------------------------------------------FLNTSGKI SSK2_Scer VGYYIDDAGELIAAEFTKLTLRLVHRLHAYLLRQQNTPPKLENE---------------- SSK22_Scer TGHYINGAETVIPNEFLKLTLRLVHKLQFYLLKQQNFPPTFANA---------------- STE11_Scer ----------------------------------------------------AISTSKKL 6622_Tthe -------------------------------------RVRIKT-IQK-NMK--------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe -------------------------------------------------QQ--------- 18758_Tthe -------------------------------------NQNLGESSTAEKAV--------- 23105_Tthe -------------------------------------NNSNNQ-NQN-NSI--------- 29763_Tthe -------------------------------------NGFDGQSYQS-NEI--------- MEKKalpha_Ddis ----------------------------------------------------TPPGSP-- CC1G_12014_Ccin -----------------------------------------PP----------------- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin VSLT-AGGSSLVAEHLCSLTNKLMVRVTNYFDTQVRVPLSDKQS---------------- CC1G_10513_Ccin ----------------------RGHRSQMFARVPKQPPQSLPSSSTESRSSSSRSASKPI GK078_Glam ------------------------------------------------------------ BCK1_Scer YIKDQMKLQQKPKPAPLTSENNVPLKSVKSKSSMRS----------------GTSSLIAS SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer YLRTL-----------------------SALSQVGP----------------SSSNLLAQ 6622_Tthe ------------------------------SPTYQNLN-----------KEKLSQNDLA- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------NLSINN------------------------ 18758_Tthe ------------------------------EEQERK----------------KPQGFVE- 23105_Tthe ------------------------------SSSFQNIGGHQNNFPISTESNRNSINNLS- 29763_Tthe ------------------------------NSTYNQ----------------GSENHLN- MEKKalpha_Ddis -------------------------------------------------------RFALN CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin --------------------------------AL-------------------------- CC1G_13687_Ccin ---------------GNQS-NG------------GP----------------VTSSAPSS CC1G_10513_Ccin YLPKAVHS-KPPDSYPKGTSSTVPLKSLGKGKSM-------------------------- GK078_Glam ------------------------------------------------------------ BCK1_Scer TDDVSIVTSSSDITSFDEHASGSGRRYPQTPSYYYDRVSNTNPTEELNYWNIKEVLSHEE SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe --------------DFENQQNQ-------------------------------------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe --------------KIR------------------------------------------- 23105_Tthe --------------SINNNNNI-------------------------------------- 29763_Tthe --------------KMRKS----------------------------------------- MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer NAPKMVFKTSPKLELNLPDKGSKLNIPTPIT-----EN------ESK-SS------FQ-V SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer -------------------------------------NKGISHNN-AEGK------LR-I 6622_Tthe -------------------NGEKIKTEQNKIDNEGQF---QVQNE-E-EQ------IS-P 7147_Tthe -------------------------------------------------L------IF-I 11359_Tthe -------------------------------------------------V------IV-Q 15684_Tthe --------------------------------------------K-QEET------IV-P 18758_Tthe -----------------------------QLKNVNAK---QVEND-QQQN------IN-V 23105_Tthe -------------------NNSCSNTNHNNKSNLSSY---KRQEK-K-YRISKTQILF-P 29763_Tthe -----------------------------------QH---NKYSK-KNRH------IV-N MEKKalpha_Ddis -------------------------------------NSNSNSNS-SVNN------IP-T CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin -------------------------------------D------N-A------------- CC1G_13687_Ccin -------------------------------------NSGKASSDA-TTSG-----QRLT CC1G_10513_Ccin -------------------------------------D------N-L-RQ------FS-Y GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------LR-K-DE--GT-EIDFNHRR---- SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------DN-TEKD--RI-RQIFNQRP---- 6622_Tthe ------------------------------------IK-NKIN--KI-QSINAIIPEKY- 7147_Tthe ---------------------------------------------------IYT------ 11359_Tthe ------------------------------------AN-SKIN--K-------------- 15684_Tthe ------------------------------------TS-PKTQ--K-------------- 18758_Tthe ------------------------------------NN-SKVN--KL-QSPATTMAF--- 23105_Tthe FNSKENICDPESQNAAQNSSSKNNTSNACNQNQSNHNSSQKIN--NI-------NNSHYG 29763_Tthe ------------------------------------NL-VNGQ--N-------------- MEKKalpha_Ddis ------------------------------------NN-NNNNHHHIIHQLNLNSPS--- CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ------------------------------------D----------------------- CC1G_10513_Ccin ------------------------------------NS-SKAP--TI-KPPHPQLPS--- GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe -----------L--------------------PKTPSGEKFHQKQESSRP---------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ----------------------------------------T------------------- 18758_Tthe ---------RSL------------------------------------------------ 23105_Tthe SNSNNLHALKLI--------------------SHN--------------PKIVNNQNFEE 29763_Tthe ----------------------------------------Q------------------- MEKKalpha_Ddis ---------PPPPLRTPP------------------------------------------ CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ---------RPPVVREPVYLAAGSFGVPKSYEP--------------------------- GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe --------------KHNEDI---------------------------------------- 23105_Tthe DVILFNKAISQPTEVLREQMALGTPPQLAAYTTSATTDTIHRQSFRIKHYNLSSRQSSRG 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------PRAIRPLPVQGSHYPQSPDANSRS GK078_Glam ------------------------------------------------------------ BCK1_Scer -------ESPYTKPELAPKREAPKPPAN---------T---SP-Q-------RTLSTSKQ SSK2_Scer ---------------------A--------------------AAEKWLVQIFEILGSMKR SSK22_Scer ---------------------S--------------------EAEKWLSSIFENLGAMKR STE11_Scer -------PSEFISTNL--AGYFPHT----------------------------------- 6622_Tthe ----------SSG----------------------------------------------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe GLKSTQTSDPISSL---------------------------------------------- 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis -------P--------SPPSSSP-PSSSPQSSFIFEQTDFHFE-E-------LS--KNNS CC1G_12014_Ccin ----------------SPSNEAPSPPPP--P----------LW-Q-------SGAGNAKR CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ---------------------G--------------------QIINWYSKILDGVRLRYR CC1G_10513_Ccin GFPSYGKPSPYMPTPL----------STNLTSPNRDMYGRDHP-P-------RPLSASD- GK078_Glam ------------------------------------------------------------ BCK1_Scer -------------NKP----------------------IRLV-RASTKISRSKRS----- SSK2_Scer --KLNRFTNILTKAF----------------------------QNFVRYKIED-H----- SSK22_Scer --KLNRFSNILVKAF----------------------------QNSAVYQINH-N----- STE11_Scer --DM-------------------------------------------------------- 6622_Tthe -----RNQNF-----I----------------------IKMV-NNHNYSDVNH-I----- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe -----QTHNN-----IGESISQSNTNNNTNQLYYELGDLSPC-NKHQNPPQYH-YHHNNF 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis PKNS---NFLNTIDQP----------------------HQIYQPH--------------- CC1G_12014_Ccin PSKL---RNFFGQRPP----------------------SELITDH--------------- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin --KLQRFARVLTQRF----------------------------SNSAEYSIDD-V----- CC1G_10513_Ccin -------------------------------------------NHTTSPTYSQR------ GK078_Glam ------------------------------------------------------------ BCK1_Scer ---------------------KPLPPQLLSSPIEASSSSPDSLTSSYTPASTHVLIPQPY SSK2_Scer ---------------------N-------------------------------------- SSK22_Scer ---------------------A-------------------------------------- STE11_Scer ------------------------------------------------------------ 6622_Tthe ---------------------H-------------------------------------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe NQNNFPYNYNFNQKSSSNINSS-------------------------------------- 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis -------------------------------------------------------QPHYQ CC1G_12014_Ccin -------------------------------------------------------LPEFF CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ---------------------AM------------------------------------- CC1G_10513_Ccin --------------------------------------------SNQSPSYGGTMS---- GK078_Glam ------------------------------------------------------------ BCK1_Scer KGANDVMR----RLKTDQDSTST-S-P--------------------------------- SSK2_Scer --------YLLKQLKETG-HFLIYTGGYLEQNGTYLIGSPELLGCKDDDILRIIKNSDIG SSK22_Scer --------QLVKKLKDAH-YFLVYSGNTFESSGVYMFAAPELLGCDNDTILRILRNKSIG STE11_Scer ------KR----LQKTMRES---------------------------------------- 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis QQQ--QQQ----QMYNFNQ---------------------PLSP-SPPL-QSQQKQQ--- CC1G_12014_Ccin PMA--EKK----VLRTARHSILLRS-GTLKRQSALSGGSIQLPP-PPPL-PSRFSTS--- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin -------DHLINLLVLTD-HFLVYT-QTMEEESIYIVASGSLYD-RPDLIRRILVE-AFH CC1G_10513_Ccin --------------------------P----SRSYG-----IGG-PRTL----------- GK078_Glam --------------------------AAVDQSGISLLAAGDN------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer CDLVPK-----------------------------LEINNSLTIY--NALDDNWNSNSSL SSK22_Scer CDLVPK-----------------------------LDIGNNLNVY--DITTKETDLNILV STE11_Scer ------------------------------------------------------------ 6622_Tthe --------------------------------------NNNLNNA--NNGS--------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe --------------------------------------QLYLNNY--EDHEEEDE----- 23105_Tthe --------------------------------------NNNINNAHLNYGS--------- 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis -----QQ----------------------------------------------------- CC1G_12014_Ccin -----TQGSGCRRSMSPGRASITSL---PPPPLPEK------------------------ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin VDEI-------------------------------------------------------- CC1G_10513_Ccin ------------------------LHHSGHSDRSSD------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer GSDISNDGTPFYYI-KNDLT---TQPR-SYNGNRVNREPDFENSRSTEEEFYELETRLNS SSK22_Scer SKGEDSKGIPYYRVVANSSSDLDRHAH-QSKKKNFSTDPFDQHLDEKNNEVFELEVALSS STE11_Scer ------------------------------------------------------------ 6622_Tthe ----------------------N-TV-IRLQSKEISDT---------------------- 7147_Tthe ---------------------------IKI------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ----------------------E-EIEYKI------------------------------ 23105_Tthe ----------------------N-HV-NNQQGRILSSR---------------SANKISQ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin ----------------------------------DEGEPI-------------------- CC1G_10524_Ccin --------------------------------------P--------------------- CC1G_13687_Ccin --------------------------A-SEEGG----------VRAVSADY--LLHDSDE CC1G_10513_Ccin ----------------------------------VPSGPETSNSTPPRTPISPVSCKSSP GK078_Glam ------------------------------------------------------------ BCK1_Scer SLKMKQKVNRSNS-TVSTSNSI------------------------FYSPSPLLK----- SSK2_Scer LGYV-LVLTPQEP-LLWEGEMYNLSDNKTIKPE--GLNLKVIPNSIDLMCQGSSYALEYQ SSK22_Scer LGAL-VVLYPGEP-VVWDGPVYKLPGNNLFASNEMDLGKIGNPNTLILLNQGSNYALTYQ STE11_Scer ------------------------------------------------------------ 6622_Tthe -------------PKS-------------------------------------------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe NMIKKIIRQPSTHIQSEEGNS-IIRRGN-IQ----------------------------- 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin ------------------------P--RM----SL----STDDGH--------------- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin VGYL-LVLTPHTP-FIWHGRVMFVPVPNI----SL----DLKEGRIRLIADGSYGRLNYA CC1G_10513_Ccin AGKMPLVIEPSSP-ASDSGNATYIS--NV----SS----VDSEKTIREDDKTQLA----- GK078_Glam ------------------------------------------------------------ BCK1_Scer --------RGNSKRVVSSTSAADI-------------------FEENDITFADAP----- SSK2_Scer CDRFQ------------------------------------------------------- SSK22_Scer IDKFN------------------------------------------------------- STE11_Scer ------------------------------------------------------------ 6622_Tthe --------------------------------------QNR----------EEKYQES-- 7147_Tthe ---------------------------------------------------ESKFSPS-- 11359_Tthe --------------------------------------Q--K--------MQKNNAKS-- 15684_Tthe --------------------------------------Q--E--------EKQVCNIS-N 18758_Tthe --------------------------------------N--R--------EDTQFSD--E 23105_Tthe --------------------NNKLNQQVNAIVRKNSYWQNQREQLERKKKKEKSMISS-- 29763_Tthe --------------------------------------Q--K--------EEDKFSHS-- MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin -----------------------------------------------------S------ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin KQVFSDCME--------------------------------------------------- CC1G_10513_Ccin --------ALLN--------------------------------NMNALMSSDRLPVSAS GK078_Glam ------------------------------------------------------------ BCK1_Scer ----------------P----MFD---SDDSDDDS---SSSDDI---------------- SSK2_Scer ---------------------QIS---G-SS----------VSFLEKKSSSETVKNNL-- SSK22_Scer ---------------------QTV---G-DS----------VSFIEKRCSLNSIESSL-- STE11_Scer ------------------------------------------------------------ 6622_Tthe YNEIKDR----ID-TQ---NSQQIGDSLQNLDEE-------------------------- 7147_Tthe KGNILA--------N-------------QNLDGS-------------------------- 11359_Tthe DSQLEA--------N-------DQCSQIQDLDGI-------------------------- 15684_Tthe EIQLEK--AAPVTPQI-------------------------------------------- 18758_Tthe SA------NSPNKSNKFQLSSSDASNGLQSTNGKS------INLLQQK------------ 23105_Tthe NNDVTETHHTIIAAQQ---NQQTEPFSIDDQEEE-------------------------- 29763_Tthe ES--EH--PSPKQGGE---NAEKEADSLQITYFY-------------------------- MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin ---------------ID----L-H---SDDDDDDI---PL-------------------- CC1G_10524_Ccin ----------------D----YSD---SDDDD--S---IW-------------------- CC1G_13687_Ccin ---------------------LVE---G-DDDNSGVEPLYLTCLVETQAHLPSVNREL-- CC1G_10513_Ccin ETSMAV---------ND----LSS---SDESDYEG---SGGTWIKPYQDRPPSARPELTK GK078_Glam ------------------------------------------------------------ BCK1_Scer IWSKKKTAPE-------TN----------------------------------------- SSK2_Scer -------------------------------------------------QRINKAYFRCT SSK22_Scer -------------------------------------------------QKINKAYYKLT STE11_Scer -------------------F---------------------------------RHSARL- 6622_Tthe -----------------QK----------------------------------------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe --------------KENQA----------------------------------------- 23105_Tthe -----------------NK----------------------------------------- 29763_Tthe -----------------FK----------------------------------------- MEKKalpha_Ddis -------------------QQQQQQQQQQPQQQQQQQQQQQQQQQQQQQQQF-NNSFENG CC1G_12014_Ccin --S-ASVAPRLLPPIETGSF---------------------------------SQSME-- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin -------------------------------------------------RKIVRATNRLA CC1G_10513_Ccin LRTDLPSTPD-------P------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer -----------NE-NKKD------------------E----------------------- SSK2_Scer YSVLKNYTKIVTTFKKVSPVNDLLNNIFLFGRDFGLNFLRINVANNEKRSIIILLMMRLS SSK22_Scer YTVLNNYKGILGSFMKQCPGNELLNSIFMFGRDFGRSFLKYNAFSSKRKYVIIFLMVKLG STE11_Scer --------SIAQR-RPLS-----------------AESN------------------NIG 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ------------------------------------------------------------ MEKKalpha_Ddis --------GIKLP-RPLS-----------------PTFL------------------NIN CC1G_12014_Ccin --------EITGS-RPAS------------------RAT------------------SIG CC1G_10524_Ccin -----------QA-RPRE------------------R----------------------- CC1G_13687_Ccin ESIVDSVHHVKRSLRGASNSQDLLGNWYLFASEHGAHAHRYMEKSSLARF--NRLLVKLA CC1G_10513_Ccin -----------AD-KVRE------------------E----------------------- GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------KSDNSST----HSDE--------------------- SSK2_Scer IGWL--------KFLAEDCDPTDQRVFRWCV----TSMEFAM------------------ SSK22_Scer MNWL--------KFLVEECDPTDQRTFRWCV----LAMDFAM------------------ STE11_Scer DILLKHSNAVDMALLQGLDQ----TR-LSS------------KLD---TTKIPKLA---- 6622_Tthe -------NE----------------------------------K---QISEQKQNK---- 7147_Tthe ------------------------------------------------------------ 11359_Tthe --------D----------------------------------GS--EVFQVQMQR---- 15684_Tthe -----------------------------------------------NLEEEQFKK---- 18758_Tthe -------NT----------------------------------Q---QQEELISVN---- 23105_Tthe -------NQ----------------------------------H---LL--FKF-P---- 29763_Tthe -------NV----------------------------------I---QVEEIRQLK---- MEKKalpha_Ddis NN-----------------------I-INS------------NLN--------NNN---- CC1G_12014_Ccin SKRL--------SFMSELRS----KRDRSDTASMMTVDEITAEVESRRVSKMPDMS---- CC1G_10524_Ccin ------------------------QPRRSSGQR--------------------------- CC1G_13687_Ccin VSWA--------SFICDDCDPTDRKTFKWTV----NSLEFIM------------------ CC1G_10513_Ccin ------------------------RPNPSASQSQGYQNG----------------GPSSQ GK078_Glam ------------------------------------------------------------ BCK1_Scer -----------IFYDSQTQD--KM---------ERKMTFRPSPEVVYQNLEKFFPRA-N- SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ----PNSNQNI---S----SKIQS---------L-----------------NYIN-E-ER 7147_Tthe ------------------------------------------------------------ 11359_Tthe -------------------SNLQS---------D-----------------GY------- 15684_Tthe -------------------E--NS---------D-----------------AY------- 18758_Tthe ----NSNAKNIDFYKDESKN--NQ---------EEK---------------KTFKNDQDQ 23105_Tthe ----SKD----------------E---------K-----------------QFFIQH-DK 29763_Tthe -------------------N--NN---------D-----------------KY------- MEKKalpha_Ddis ------------------------------------------------------------ CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin YQLPPPQ----RFPPGNQQH--RDHRVSGFADGDDDWAPRPPPEDVYDRLEEFFPEH-D- GK078_Glam ------------------------------------------------------------ BCK1_Scer -LDKPIT-----------EG---IASPT-----SPKSLDSLLSPKNVASSRTEPSTPSRP SSK2_Scer ------------------HMVSGWNILAL----DECQFSSLKQKISECMSLLISHFDII- SSK22_Scer ------------------QMTSGYNILAL----NVKQFQELKERVSVCMSLLISHFDVM- STE11_Scer ---------------------------------H--------------------KRPED- 6622_Tthe ELDSSPIEQGQNS---KLK-----------------------DKNNDKQN---------- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ---------------------------------------------RDR------------ 15684_Tthe ---------------------------------------------FTREQ---------- 18758_Tthe IIQTKSIRERFSLP-----------------EKPKDSQIPPIKEI--------------- 23105_Tthe NIDQANINRRDNSPKLCLNISNNNNLNTINTNNPKSSKRTSIGRISQKQQQLLAHQPVH- 29763_Tthe ---------------------------------------------FTKED---------- MEKKalpha_Ddis ---------------------------------N-------------------------- CC1G_12014_Ccin ---------------------------------NANDLEGWTKVENAASFDTAPTVPAD- CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ------------------QRTK-RNILHI----PDDQFELLKAKVGHCMSLLINHFDIL- CC1G_10513_Ccin -LDKLVI-----------EANSGGNSPT-----NPEPTTAIPTPVSANATVIMPQHPHR- GK078_Glam ------------------------------------------------------------ BCK1_Scer VPPDSSYEFIQDGLNGKNKPLNQAKTPKRTKTIRTI--AHEASLARK------------- SSK2_Scer ---------------------------GAR-SIEVEKINQQARSNL-DLEDV----FDDD SSK22_Scer ---------------------------GAR-ATEAENGMQQARLNI-DTEEN----IDEE STE11_Scer -------------------------------NDAIS--NQLELLSV-ESGEE----EDHD 6622_Tthe ------------------------------------IIKEQ------------SQN---- 7147_Tthe ------------------------------------------------------------ 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------YIKVQ------------------- 18758_Tthe ----------------------------------------S------------RAN---- 23105_Tthe -----------QVQVQQ-------------------NINQQ------------HQQ---- 29763_Tthe ------------------------------------Q----------------------- MEKKalpha_Ddis -------------------------------------------NNN-NNNNN----NNNN CC1G_12014_Ccin -------------------------------EVEVD--DDEATLAT-EDDED----EDED CC1G_10524_Ccin ------------------------------------------------------------ CC1G_13687_Ccin ---------------------------GAR-SNMEAKMEKEKQEML-LRSKVVDSRLDEE CC1G_10513_Ccin ---------------------------RHKKSIRIV--AQEQKRKMNDQTSR----VDPA GK078_Glam ---------------------------------------------Y-DNYDN----EDD- BCK1_Scer --------NS--VKLKRQNTKMWGTRMVEVTEN--------------------------- SSK2_Scer MM-------------LQVNSEF---RVQSIMELEERIKRNP-HQTGKVI-------DDSD SSK22_Scer AT-------------LEINSRL---RLEAIKTLEKTMKRNP-RQMGKVL-------DATD STE11_Scer FF-----GED-------------------------------------------------- 6622_Tthe ---------------------Q---RQESSMMLQTASEKKEINNLKYIIESN------NL 7147_Tthe --------------------------------------------------AN--NIKEDE 11359_Tthe --------------------------------------------------VN--FNNQDY 15684_Tthe --------------------------------------------------QY--LVNEET 18758_Tthe ---------------------S---Q------KDN-----STSQSPSILA------QS-- 23105_Tthe ---------------------Q---QQQQLQQIQQIQNKFPQFNLQSQLQSNGQNILNSI 29763_Tthe --------------------------------------------------E-------YY MEKKalpha_Ddis NN-----NNN-NN-------------IIQHTD---------------------------- CC1G_12014_Ccin DS-----DD--------------------------------------------------- CC1G_10524_Ccin --------------L--------------------------------------------- CC1G_13687_Ccin DFPPCPSGEEGSWYLDGSTRKFWDRVSKALQELEERTVVIP-QYRGKVL-------DDEK CC1G_10513_Ccin PY-----GQN--AMLRKRNTKMWGSKLEEVTTMQV------------------------- GK078_Glam --------------------------------------------------------NEDK BCK1_Scer -HMVSIN-KAK----------------------------NSKGEYKEFAWM----KGEMI SSK2_Scer KGNKYLV--SL----------------------------ASSISNVSMRWQ----KRNFI SSK22_Scer QGNKYLL--SL----------------------------ASSLSNVSMRWQ----KRSFI STE11_Scer ---SDIV--SL----------------------------PTK-IATPKNWL----KGACI 6622_Tthe NQNN-NN----------------------------------SSSNDYLDAQ----VGELI 7147_Tthe NQNN-Q-------------------------------------NIQLKRYK----KCELI 11359_Tthe DRNG-DM-SC-----------------------------RNQETKRVLTFK----KGHII 15684_Tthe QLKE-QI-ELE----------------------------NQMG---KQKWIPGKTDDKIL 18758_Tthe ---E-LE-NSK----------------------------AEASLQKIVKWK----SGDFI 23105_Tthe NQNN-NLFSLNQMSTLLNIKTLSIKKAISNDYSNRHDDIMITGTNPFHDVE----LRELL 29763_Tthe EKKY-YN-EKK----------------------------VQPPKDKNIRWQ----SGEVL MEKKalpha_Ddis FPSLIIN--EH----------------------------EELISNHNIKWQ----KGQIL CC1G_12014_Ccin --------DFG----------------------------IAIPTRTNNKWI----KGALI CC1G_10524_Ccin ---------PY----------------------------QRSFVKPTFQWI----RGELL CC1G_13687_Ccin LEDRSLV--FL----------------------------ASSSSNISIRWQ----QGRFI CC1G_10513_Ccin RTSSTIP-ESP----------------------------SSAGSPPTFKWV----RGELI GK078_Glam RPDR--E--FS----------------------------PPKPRQRHLKYS----LGRII : BCK1_Scer GKGSFGAVYLCLNVTTGEMMAVKQVEVPKYSSQ--------------------------- SSK2_Scer GGGTFGRVYSAVDLDNGEILAVKEINIQDSK----------------------------- SSK22_Scer GGGTFGQVYSAINLENGEILAVKEIKIHDTT----------------------------- STE11_Scer GSGSFGSVYLGMNAHTGELMAVKQVEIKNNNIGVPTDNNKQANSDENNEQEEQQEKIEDV 6622_Tthe GQGAYGRVYKGFVKSTGKFIAIKEMKEEMMLG---------------------------- 7147_Tthe DKGAYGKVYKGIDTITNQVVAIKYIEITGTF----------------------------- 11359_Tthe DRGSYGEVYQCLEVNTGQLYAIKTIRKNKD-K---------------------------- 15684_Tthe GKGTFGTVVLGHNKNTGEIVAVKLIETQY------------------------------- 18758_Tthe GAGSFGQVFTAMNCNTGEIFVVKKIMVHGQS----------------------------- 23105_Tthe GEGAYGKVYKGFIKKTGKFIAVKQLKLGLKDN---------------------------- 29763_Tthe GTGSFGQVILGMNIDTGEFMAVKQVHIGGYNQ---------------------------- MEKKalpha_Ddis GRGGYGSVYLGLNKDTGELFAVKQLEIVDINS---------------------------- CC1G_12014_Ccin GAGSFGKVYLGMDASNGLLMAVKQVELPQGDGP--------------------------- CC1G_10524_Ccin GKGSYGRVYLALNATTGEVMAVKQVELPKTPSD--------------------------- CC1G_13687_Ccin GAGAFGSVYLAMNLDSGSLMAVKEIKFQELS----------------------------- CC1G_10513_Ccin GKGTYGRVYLALNATTGEMIAVKQVELPQTPSD--------------------------- GK078_Glam GHGSFGQVYLALEHLTGKLLAVKEMVVKNC------------------------------ . * :* * .. . .:* : BCK1_Scer ---------NEAILSTVEALRSEVSTLKDLDHLNIVQYLGFENKN--NIYSLFLEYVAGG SSK2_Scer -----------SMQKIFPLIKEEMSVLEILNHPNIVSYYGVEVHR--DKVNIFMEYCEGG SSK22_Scer -----------TMKKIFPLIKEEMTVLEMLNHPNIVQYYGVEVHR--DKVNIFMEYCEGG STE11_Scer GAVSHPKTNQNIHRKMVDALQHEMNLLKELHHENIVTYYGASQEG--GNLNIFLEYVPGG 6622_Tthe ----------EDAHSLLESICKEIQLLKQLSHKNIVNYIGSKKQE--GSVYIYMEYMPGG 7147_Tthe ----------EEVKKEINSLKKEIVLLKKLNHQNIVKYYDFEISDDKSGVDIILEYVPNG 11359_Tthe ----------AVLEKEVQSLAKEIKEYKKLSHKNIVKYIDTELDEDEKGINIILEYVSGG 15684_Tthe -----------DRKQKYKSIIDEVKILKQMRHKNIVRYYGIQEHKAKDHIGIVCEYVSGG 18758_Tthe ----------KLDKEFLDEQEKELRIMQTLSHKHIIQYKGHERQQ--DCLCIFLEYMSEG 23105_Tthe ----------NKLQEKLEQYLQEIALLNHLEHPNIVKYYDCKHEE--DNILIYMEQMPGG 29763_Tthe ----------KDRQEKIQQIQSEIEALRNFSDKNIVRYIGIKKS--ETSINIFLEYVPGG MEKKalpha_Ddis ---------DPKLKNMILSFSKEIEVMRSLRHDNIVRYLGTSLDQ--SFLSVFLEYIPGG CC1G_12014_Ccin --------SQERKKSMLSALEREIELLKVLQHENIVQYLYSSSDD--EYLNIFLEYVPGG CC1G_10524_Ccin -------KMKPQQLDVMKALKFEGDTLKDLDHPNIVSYLGFEESQ--DYLSIFLEYVPGG CC1G_13687_Ccin -----------GLPNLYAQIKDELSVMEMLHHPNVVEYYGIEVHR--DKVYIFEEYCQGG CC1G_10513_Ccin -------RNDSRQNTVVQALKLESETLKDLDHPHIVQYLGFEETP--ANLSIFLEYVPGG GK078_Glam ------------SREVLEAIDAETRILINLRHPNIVNIYDIEVSDDGNKLLIVMDFIAGG * : . ::: . : : * BCK1_Scer SVGSLIRMYGRFDEPLIKHLTTQVLKGLAYLHSKGILHRDMK---------ADNLLLDQD SSK2_Scer SLAALLEHGRIEDEMVTQVYTLQLLEGLAYLHESGIVHRDVK---------PENILLDFN SSK22_Scer SLASLLDHGRIEDEMVTQVYTFELLEGLAYLHQSGVVHRDIK---------PENILLDFN STE11_Scer SVSSMLNNYGPFEESLITNFTRQILIGVAYLHKKNIIHRDIK---------GANILIDIK 6622_Tthe SISEMLKKYGGFDEEVIQKFVKQLLEGLIYLHSKGVIHRDLK---------GANILSDGQ 7147_Tthe SLRMALNKQRCFDETKAAIYTKQVLEGLDYLHKNNIIHRDLK---------GANLLLDAE 11359_Tthe SIRQMLDKFGKFNEKVISIYTNQVLQGLKYLHSNHVFHRDIK---------GGNILIDTD 15684_Tthe SLWRLIQKFGKFSEPLIRKYTTDILYGLQYLHYHGITHRDIK---------GANILVDSD 18758_Tthe NIDQMLKKFGPLEEQTIKVYARQILSGIQYLHSQKVIHKDIK---------GANILVGSD 23105_Tthe SLSSMLEKFGRFEEALIKKFVKQIISGLAYLHSQGIVHRDIKLTYINKILQGANILTDGN 29763_Tthe SISSLLYRYGKFNETLIRKFTQQILKGLEYLHAHEIIHRDIK---------GANVLVDKD MEKKalpha_Ddis SISSLLGKFGAFSENVIKVYTKQILQGLSFLHANSIIHRDIK---------GANILIDTK CC1G_12014_Ccin SVATLLSNYGAFEEPLVRNFVRQILQGLSYLHERDIIHRDIK---------GANILVDNK CC1G_10524_Ccin TVGSLLVKNGRLREEVTKSWLRQILQGLDYLHGKGILHRDLK---------ADNILVDHS CC1G_13687_Ccin SLAALLEHGRIEDERILQLYTVQMLDGLSYLHSQGIVHRDIK---------PDNILLDQL CC1G_10513_Ccin SIGSCLHKHGKFSENVTKSFTGQILSGLEYLHSKGILHRDLK---------ADNILVEMT GK078_Glam SLASLSKSFKGIPEILCRRYARQILEAIKHMHRQNVAHLDLK---------CSNIMIGGD .: * ::: .: .:* : * *:* *:: BCK1_Scer GICKISDFGISRKSKDI--YS-------------------------------NSDMTMR- SSK2_Scer GVIKYVDFGAAKKIANNGT--RLASMNKIENADGEHEDVTHVSDSKAVKNNENALLDMM- SSK22_Scer GIIKYVDFGTARTVVGSRT--RTVRNAA----------------VQDFGVETKSLNEMM- STE11_Scer GCVKITDFGISKKLSPL--NK-----------------------------KQNKRASLQ- 6622_Tthe GNVKLADFGAARNIENIL--QHS-------------------------LSQSEFCNSIK- 7147_Tthe GRAKLTDFGTAKQIEFDL--RKSQVKE---------------------EDIAKMNKSLK- 11359_Tthe GTIKLTDFGTLKLHKKDAYINHSKSQS-------------------QLSHNQLDYGTIQS 15684_Tthe GVCKLADFGLAKSISQEI--D------------------------------EGQLKLPQ- 18758_Tthe GIVKLSDFGCAKQLELTL--N----------------------------SNKEMNKTLK- 23105_Tthe GTVKLADFGAARYRDTIC--LPT-------------------------ADGSEFCNSIK- 29763_Tthe GNCKLADFGSAKKIVEE----------------------------------KGHNDSIR- MEKKalpha_Ddis GIVKLSDFGCSKSFSGI--V--------------------------------SQFKSMQ- CC1G_12014_Ccin GGVKISDFGISKKVDDNL-LGG----------------------------NRLHRPSLQ- CC1G_10524_Ccin GVCKISDFGISKKAGEI--NR-----------------------------A-KAHTGMK- CC1G_13687_Ccin GRIKFVDFGAAKILAKNQH--TLQRSRRST-------DAA----FNAANGIGVMSNGLT- CC1G_10513_Ccin GICKISDFGISKRTDDL--HG-------------------------------GAFTAMQ- GK078_Glam GLVKLVDFGTATRLARDDIINELQRRK-ETEAD--PKKPG-----LPSEAAKKFNLGIK- * * *** BCK1_Scer GTVFWMAPEMVDT-K-QGYSAKVDIWSLGCIVLEMFAGKRPWSNLEVV---AA-MFKIGK SSK2_Scer GTPMYMAPESITGSTTKGKLGADDVWSLGCVVLEMITGRRPWANLDNE---WAIMYHVAA SSK22_Scer GTPMYMAPETISGSAVKGKLGADDVWALGCVVLEMATGRRPWSNLDNE---WAIMYHVAA STE11_Scer GSVFWMSPEVVKQ---TATTAKADIWSTGCVVIEMFTGKHPFPDFSQM---QA-IFKIGT 6622_Tthe GSLYWMAPELIKNE---KHGRRIDVWSLGCTVIEMASAQHPWENIKKF---SD-LANAVI 7147_Tthe GTPNWMAPEVIERT---GHTTSADIWSIGCIVIEMITGKPPYPGLSAK---EV-FTKIAS 11359_Tthe QKPFWTAPEVLKNED--SHDASSDIWSVGCLVIEMITALPPYYNLNDKSS-QE-ITKYIM 15684_Tthe GTPNWMAPEVCRS----GTCRFSDIWSLGCTVYEMITGKPPFSNFLAE---TI-ILRVGL 18758_Tthe GSVPWMSPEIVTQT---KYDTKADIWSFGCTILEMAQAEAPWSNYQFDNPIAA-IMKIGL 23105_Tthe GSLYWMAPELLNQE---SHGRKSDIWSLGCTMIEMATGKHPWPDCRTF---PQ-LALIVK 29763_Tthe GTPYWMAPETIKQL---GS------GSIGCTVIEMATAKPPWADKSPI---QA-MFYIAN MEKKalpha_Ddis GTPYWMAPEVIKQ---TGHGRSSDIWSLGCVIVEMATAQPPWSNITEL---AAVMYHIAS CC1G_12014_Ccin GSVFWMAPEVVKQ---TGHTKKADIWSVGCLVVEMLTGEHPWAQLTQM---QA-IFKIGS CC1G_10524_Ccin GTSFWMAPEILSPGE-KGYDVKVDIWSVGCVAVEMWTGKRPWYGHEWW---PV-LMKVAE CC1G_13687_Ccin GTPMYMSPEMIKNDR-RGRHGATDIWSLGCVILQCATGRKPWSNLDNE---WAIMFHIGV CC1G_10513_Ccin GTVFWMAPEVINTQK-KGYNFKIDIWSVGCVVLEMWGGRRPWTGQEMV---TV-MFKLYE GK078_Glam GSPYWIAPECVRSTLY--DIFKADIWSIGCLFIEMFTTYPPFFQFKQV---PALLYHIAT . : :** : ** : *: : BCK1_Scer SKSAPPIPEDTLPLISQIGRNFLDACFEI----------------------NPEKRPTAN SSK2_Scer -GHTPQFPTKD--EVSSAGMKFLERCLIQ----------------------NPSKRASAV SSK22_Scer -GRIPQLPNRD--EMTAAGRAFLERCLVQ----------------------DPTMRATAV STE11_Scer N-TTPEIPSW----ATSEGKNFLRKAFEL----------------------DYQYRPSAL 6622_Tthe EQQPIPIPQH----LSEECKDFISKCCT----------------------YDKKMRPKSQ 7147_Tthe G-----------------------GCLQ----------------------TDPKKRLTTS 11359_Tthe DGNIPNFPEK----LSEQCLEFLQKTLK----------------------VNPKERATVN 15684_Tthe LKQPPQFLENL--QISEKLSDFLLHCFQ----------------------IKPEERWNVD 18758_Tthe SDEIPQIPET----ISPDLNQFIRKCLQ----------------------RDPSKRPTAT 23105_Tthe TNQCPPIPEH----LSDECKDFIRQCCT----------------------FDKKERPTAD 29763_Tthe AQQPPPIPEH----LSPVCKDFISKCLKYQNQIELVDLTKTQQILFLQFRINPNDRYNVR MEKKalpha_Ddis SNSIPNIPSH----MSQEAFDFLNLCFKR----------------------DPKERPDAN CC1G_12014_Ccin S-ARPTIPSD----ISAEAQDFLQKTFEI----------------------NHELRPHAA CC1G_10524_Ccin DKSPPPIPEDI--PMGHLAQSFHNQCFRP----------------------DPADRPHAS CC1G_13687_Ccin STQHPPLPEPG--QLSPLGIDFIKQCLTI----------------------DPTFRPSAK CC1G_10513_Ccin AKLPPPVPDDV--VLSELGDDFRRKCFAIFMTDG--------------ACSNPDERPPAA GK078_Glam ITEPPGLPE----TMSDEGRDFLSKCLQI----------------------NPEARASVD . * BCK1_Scer ELLSHPFSEVNET-FNFKSTR--------------------------------------- SSK2_Scer ELLMDPWIVQIREI-AFGDDS--------------------------------------- SSK22_Scer ELLIDPWMIQIREI-AFGNSE--------------------------------------- STE11_Scer ELLQHPWLDA-------------------------------------------------- 6622_Tthe QLFNHPFLQK-------------------------------------------------- 7147_Tthe QLLKTPFILRKKIRR--PLS-------Q------NSL----------------------- 11359_Tthe ELIQLKFIAEPDLIE-LTSE-------Q---YSPNQVKSGMFQSQTSLGFVQREFPNNKN 15684_Tthe QLLQHPFIVDTDIEK--NEK-------SS-TLTRK------------------------- 18758_Tthe ELLNDSFLA--------------------------------------------------- 23105_Tthe VLLKHPFLN--------------------------------------------------- 29763_Tthe QLLNHPFILGKRLTH--VSQ---PGR-QLPLITEEAT----VDYQTSSPDKRKE------ MEKKalpha_Ddis QLLKHPFIMNLDDNIQLPT------------ISPTT----TL------------------ CC1G_12014_Ccin ELLQHPWLSKKGK-KAA------------------------------------------- CC1G_10524_Ccin VMLKHPYLEIQSP-WVFNWDDLADNSRP-PRIYPELVP--PV------------------ CC1G_13687_Ccin ELMDHPWMLDLQAA--LEDDG----------L---------------------------- CC1G_10513_Ccin ELRLHPYLELPPG-WTF------------------------------------------- GK078_Glam DLLAHPWVAMVNLT--FGIHP----------LVPDKP---AV------------------ : : BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ----------------------------VSQE---------------ELLE-Q------- 11359_Tthe GLRIQNDFYNDEPPQFMRDA-------GFFENQDNYNANKNDRNREDESLI-D------- 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ------------------------------------------------FLT-RGESRGNT MEKKalpha_Ddis ----------------STNTTNTTATTTTTNNATNSNINQQQQQQQQQPPTRT------- CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ----------------VRER-------TVTQSTFKANGPPTEKPRAHKPPLEP------- CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ---------------SGREA--------------------HLQQSIDAPPSLA------- BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe -------------------------IQSIQQGQNIQQEYSRINKGSQPLIKGNSSQSIKV 11359_Tthe -------------------------LKGLSVIQND-KQFKKMTRDNTPLSKNNQQQQ--- 15684_Tthe --------------------------------------RN-------------------- 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe LFHEENSMKDTLTEKTLVFSVKTKTHKSQKSRKSIRL-RESDGENSQDSIDLGKSKNMNN MEKKalpha_Ddis ------------------------------------QR-VSISAG-------------SS CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin -------------------------LKIPAYGPTSTQRKPSVNGAGPPVV-----WITPP CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer -----LAK-----------FIKSND-KLNSS----------------------------- SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe PQIISNQNA----------------------------------SSQPLIVNK-------- 11359_Tthe ----QNYNF----------------------------------EDQIHYIDKIHQKEQLA 15684_Tthe ------------------------------------------------------------ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe PRPLNPQPK----------------------------------MIQ-------------- MEKKalpha_Ddis NN--KRYT-----------PPIST--STSSSSSSILNNFSINIILPINLIILIFREIKPN CC1G_12014_Ccin -------A-----------AAAAAA-AAASA----------------------------- CC1G_10524_Ccin NTPRRTAK-----------PEDSSA-STSTSD---------------------------- CC1G_13687_Ccin ---------------EIATSPRPD--TQS------------------------------- CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam -------TSKADKLLGLFTKTKDTDVTQS------------------------------- BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ---------------------PNPYLEYQYKNQQKYQEYQDSQ----------------- 11359_Tthe FDNQIKRIMLESKQNF--NEARDEYQQQLM------------------------------ 15684_Tthe -----------------------ASIKKQYKKNSSSSSSGDNI----------------- 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe -----------------------PSIDKNKDNNDNSSKSSDSSRSSSNSSNSQERTKNNT MEKKalpha_Ddis FVNTLSRVCKHWKQIIDDDELWNKYCSDRLINKSKFEESITWK----------------- CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin --------AAPW------------------------------K----------------- CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------IDQ---LKERTKSL----------------------NRFANEHKSST--QNDKQ 11359_Tthe -------SQ---LKEFE---------------------------------DKT--QQDQN 15684_Tthe ------VNA---LQEQPSKH----------------------ELFINQQQQLSQQQQIVQ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe QISYTGTDA---MPIRKKQV----------------------TPFSLSHKQSSLNQQ--Q MEKKalpha_Ddis ------SNY---IKIYKQQKVWFHN----------------------KLNHSTLKGHDKG CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ------STSKRRL--------VIVNPDLDDDIGPAPQNTPPKPKFVYTPPPLPDPPQPPY CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe QNQIRKIDQQTNKNINAEDEILQIAKQ---VKRQQ------------EYVQANVNPGYDQ 11359_Tthe QQNQNNVKKQEQK--DVEDEILDLIKK---KKNKRKQGNNAGANTPQQNKNSSTSTFDT- 15684_Tthe QNQQQIVQQNQQSNLTTTFTVN--VKN---NQNKRDSLRTILEESNQQYSGKSPSLFYEE 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe RQQPQSLQIQQPSEYSGTKSVY--T-----SEIDRDKSSII--TKQQSYTSQNSSEGGRQ MEKKalpha_Ddis VFCVKLIDDQGMVLSGGEDKKLKVWDI--------------------------------- CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ASSPRPLRHAVSTSFASVSSMGSISSKAGSPS----------------RPRALVDPGLSS CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe Y-IF----K---PQVESN--------------VI-------KFS-NKDH----------- 11359_Tthe --SM----QNPPPQVRYQ--------------V--------LFNNPKDNYKFLSQDETIQ 15684_Tthe Y-SFQDNNP---KDPSIQ--------------SIEGQ-KLSVFYNPDQT------NSSIQ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe NNKLLENNQ---NQLPTN--------------GIKSQERVNSPFKTQNG------NANNN MEKKalpha_Ddis ----------------------------------------------------------S- CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin T-RTP-------PRPLPNPLSPPLGRSPAPLPV---------LPSPSKR------RGSS- CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe -----------DVHSNNQNDFNP------------------------------------- 11359_Tthe HNEILLKKQYNDIQQP-ELDQSPQASKQNHSQNQVIPLSKFNSLKQQQENQEEAQNKTQE 15684_Tthe A----------------------------------------------------------- 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe Q----------------------------------------------------------- MEKKalpha_Ddis ------GNHHHNHHSGIVGSISKK-----------------SGLN-------------II CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ------RDRSHTVHT--------------------------------------------- CC1G_13687_Ccin --------------E--------------------------------------------- CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ----------TIAKN--------------------------------------------- BCK1_Scer --------------------------------------KLR------------------- SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ---------------------------LRSNSRQNTYSQLKIQPDIHANNQNEFNQQRNN 11359_Tthe KNDYIIDNSKVNESSGQIIQQDLHH--VSS-QG-KSLKKVESSE---------------- 15684_Tthe ----------------------------KQNIVKEG----------------LENQLYTN 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe ----------------------------QSNINKNGMSHFSNGVTSSANNNNDNNNDGAN MEKKalpha_Ddis NNNNSNNSNS------------------S-SNSSSS------------------------ CC1G_12014_Ccin --------------------------------------SAA------------------- CC1G_10524_Ccin --TFDASASKLYEEGNPTAKASVHNLPIS-SSGSRTIRRLPISP-----------QQLNH CC1G_13687_Ccin --CSG---DS------------------S-TTY--------------------------- CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam --WFG---KS------------------K-ANLSQSIRNLQAS----------------- BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe --------SRQ-----------------NTYSQQKGQQPQQPFRSSLVDIKDEDDMDTTE 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------S----------------------------- 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe LIRNYDSNSSN-----------------SSNKQNENNQKKQEAPIYVQNIASNNNSQNHN MEKKalpha_Ddis -----------NSRYLFSLKGHSGCIKSVDYQRQSGSDVSRVFT---------------- CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin --------GRPAT---------------TTTPSMPGSSTPRPLR---------------- CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe -MIRRSQKSLTL-------LKSKYKNLNEASS---------------------------- 11359_Tthe -------KKLQI-------LQSDPLSLTSLGI---------------------------- 15684_Tthe ----DQK-----------SKGQKYKPVNSNAFL---KDDIEEDQENQQQLPNDNFQ-TSQ 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe LILTQSQQQITLGQKQADRKSQKLRELNDSSSSSSSRPASKSPQPNQNNLPNLSKNSQSK MEKKalpha_Ddis ---------------------------------------------A-------------- CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ---------------------------------------------PQKSVPDVSIFAFSR CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ----------------------------QGKDNQIASQNEQA--LS----N--------- 11359_Tthe ----------------------------GGFDKFNVDHQDQI--LY----N--------- 15684_Tthe N---------------------------NGLQDGLLKQQQQQ--IY----N--------- 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe N---------------------------ASIDKSAIEQKKQE--AA----Q--------- MEKKalpha_Ddis SADFTCKIFSLKTKKTLFTYTNHQEAV---TCINYLGDVENKCITSSLDKTIQLWDAETG CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin DAYHSRHHPSFKSKSNRPLYTSRGSFDSEPEDINGASDNDSVSST----STTHTKHPQRG CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ----------------------------AK------------------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe -------------YHLNHSQKQNHKSSYEDL------DIE------------LPQESK-- 11359_Tthe -------------YKINQ--IQPKKSGRHQRNKTDQIG-------------------QNH 15684_Tthe -------------NTFNINANK--IDEVDGE------DDEENQDSPEKKNKKFQYQQ--- 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe -------------KQLI-Y-----IDCYDDE------DEDEE------------------ MEKKalpha_Ddis SCLSTLRGHTGGIYCVKTDQVATHGNGYNHL------------------VVSA---S--- CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin ESLLAMRPRTEDVY--------------KDL------------------EAWFPNHD--- CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ---------EVPISRNVGRQNSQITISKEQPLQQESVTEEVIETNQSEPQEENEYLKHEN 11359_Tthe NQNEASFFKEVKRDMNGGNRDNLVTYSSKE-IQSDLNIED-------------------- 15684_Tthe --------QDQNIPRNQTRSNSKVRIPS---------------KNNIKTKETDEYEEEEN 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe --------EEVQFHFDQTAVDSIMRHQG---------------NQNINNNNTQTYTNKTN MEKKalpha_Ddis --------VDK------------------------------------------------- CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin --------LDR------------------------------------------------- CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam --------IDL------------------------------------------------- BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe KVITTKAA---------------------------------------------------- 11359_Tthe ------------------------------------------------------------ 15684_Tthe DMLNSKCLRGIPTERKYDEIV--------------------------------------- 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe SEYNRNARKTVDSQQQPSQLVDTTADSFNRDKFGKLRFSKPTSPKQLNTQVSGTNFNNNS MEKKalpha_Ddis -----------------------TSNVW-------------------------------- CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin -----------------------PVDGA-------------------------------- CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam -----------------------NEDEL-------------------------------- BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe ------------------------------------------------NVQRMMLNKQ-- 11359_Tthe ------------------------------------------------------------ 15684_Tthe ------------------------------------------------DVKINAVFEH-- 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe FDQIAIDNKTVITDNTNKNKIGSLKQEQVK---EYSKYFGQGQRSRNDDYKTSSIDQH-- MEKKalpha_Ddis -------------DTRSSSKVRSFTQHTEDVLCCYVFD-QKVVTG-----------SCDG CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin -------------DTPASGALEP-RHHRVDVR------------------------KS-- CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam -------------D---------------------------------------------- BCK1_Scer ------------------------------------------------------------ SSK2_Scer ------------------------------------------------------------ SSK22_Scer ------------------------------------------------------------ STE11_Scer ------------------------------------------------------------ 6622_Tthe ------------------------------------------------------------ 7147_Tthe -LA----NKQQKQQQNFIP----------NKY--FEHQNQVINTD---------IAQRER 11359_Tthe ----------------------------------IN-QSNIENI---------------- 15684_Tthe -NIS---NLY-KQNSNFIV----------GSKS--------------------------- 18758_Tthe ------------------------------------------------------------ 23105_Tthe ------------------------------------------------------------ 29763_Tthe -I-I---NQYMQQKQNSHN----------NENNNNNNNN-SPYND---------LTRHID MEKKalpha_Ddis TI-KLWDIGTGKTISTFIPSETRQKNYVWTVQFD---QSKIISSGKTGIIRIWDIYNERD CC1G_12014_Ccin ------------------------------------------------------------ CC1G_10524_Ccin -I-RMIAKEQNRR-SHNDPASSRRRTML------------------------WNTHM--- CC1G_13687_Ccin ------------------------------------------------------------ CC1G_10513_Ccin ------------------------------------------------------------ GK078_Glam ------------------------------------------------------------ BCK1_Scer -------------------------------------ITSQENKTE SSK2_Scer -------------------------------------SSTDTEERE SSK22_Scer -------------------------------------KDQVPILSS STE11_Scer -------------------------------------------HII 6622_Tthe -------------------------------------------KYS 7147_Tthe NIRIQEQQEFIQDKIKRQQMWEEELKR----ELEYQKQNPPPYLKY 11359_Tthe ----HKNGQYDENNI--NNLSRSSLNRKH--KKENNSNNIFIENFF 15684_Tthe ------------------NQFEFQMPVYE--DYQESSLPSPQKKSQ 18758_Tthe --------------------------------------------EN 23105_Tthe --------------------------------------------GD 29763_Tthe SINI-------------DDYSESQFESYN--SKEARSKQNIITKNY MEKKalpha_Ddis SRSIGGHHE---------TIFSLQFNN-QKLITGSLDKLVKIWSID CC1G_12014_Ccin -------------------------------------SSTNDSPSS CC1G_10524_Ccin -------------------------------EELSSDKRKDSMPRF CC1G_13687_Ccin --------------------GSLAV------------PTETNSNGS CC1G_10513_Ccin ----------------------------------------TSFTSD GK078_Glam ------------------SLFELALPK-EDLSFIVLQHDKILDAGI