CLUSTAL W (1.83) multiple sequence alignment E02D9.1_Cele MLTEPILFTKDKSLQ-R-------------ANKI-TKKHFH-FL--FLSISLQAIVS--V F35C8.1_Cele MSQPPGRRMP-------RPKLDL-PP--LR------ET---------------------- F35C8.2_Cele MPTFG-RRVP-------RPKLDL-PA--LR------ET---------------------- MKK1_Scer MASLFRPPESAK-CNPNSPRLKL-PL--LRNNQV-DENNIY-LT--SNGSSTTAYSSH-T MKK2_Scer MASMFRPPESNR-SHQKTPKLTL-PVNLVQNAKS-TNDGQH-LNRSPYSSVNESPYSN-N PBS2_Scer MEDKFANLSLHEKTGKSS----I-QL---NEQTG-SDNGSA-VKR--T-SSTSSHYNN-I STE7_Scer MFQRKTLQRRNLKGLN----LNLHP-DVGNNGQL-QEKTETHQGQSRIEGHVMSNINA-I 1557_Tthe MLNDF------------------------------------------------------- 1909_Tthe MNEEQLQQCSNLKEGNE----SS-E-QQ-QEPQPQ-QQIAANVTPKNEKKEESSN-NE-S 26687_Tthe MEINSLKNSGSFST------------KIQNLNKL-QEQISQV-CEE--------DIDQVT Mek1_Ddis MNTNTNTNTNISSSGNN--IINT-P-TT-NNNNKNNNNNNNNNNNSNNSNNNSSN-NN-N 12278_Tthe MADKKKGLSFNM--------------NLTQ------------------------------ CC1G_01983_Ccin MEAKTTTLPRPMGPRGPTPGRRP-PFPTIRTTG-----------NLP-TS---------- CC1G_14241_Ccin MASNHNNRFPTSTPIPPS------------------------------------------ * E02D9.1_Cele HFSIMSGIRTFLVY------------FELE-----KCIG----------E---------- F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer PEPLTSSTSTLFSQ------------TRLHPSDSSM-------------T---LNT-MK- MKK2_Scer STSATSTTSSMASN------------STLLYNRSS------------------TTT-IK- PBS2_Scer NADLHARVKAFQEQRALKRS------ASVGSNQSEQDKG----------S---SQS-PKH STE7_Scer QNNSNLFL-----RRGIKKKLTLDA------------------FGD-DQAISKPNT-V-V 1557_Tthe ------------------------------------------------------------ 1909_Tthe NGEKTFYL-----H-KLKKKVNLNIKIPNQQKNEDYADLTNGTLFNGNVIIDKEGVKG-L 26687_Tthe PNNQ-------------------------------------------------------- Mek1_Ddis NNNNAVGV-------KTGKKVNLKVETPVQNNENSYSLTTSGTFKEGDLLINKKGLLI-K 12278_Tthe -ENM-------------------------------------------------------- CC1G_01983_Ccin ---------------------------PIQPA---------------------------- CC1G_14241_Ccin ---LQAKLAAFQANRAAPTN------NAVRSLEDAMNGV----------S---------- E02D9.1_Cele --LAEPRCLQLPEHLWR-------FWDILIAELKSEIPEI-------------------- F35C8.1_Cele ------------------------I------------PEV-------------------- F35C8.2_Cele ------------------------I------------PEV-------------------- MKK1_Scer -KRPAPPSLPSLS--INSQSKCKTL------------PELVPIADVSDGKHDLG--LKQR MKK2_Scer -NRPVPPPLPPLV--LTQK------------------------------K--DG--IEYR PBS2_Scer IQQIVNKPLPPLP--V-------------------------------------------- STE7_Scer IQQPQN------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe G----------------------------------------------------------- 26687_Tthe -----N------------------------------------------------------ Mek1_Ddis GESPKN------------------------------------------------------ 12278_Tthe -----K------------------------------------------------------ CC1G_01983_Ccin ----DPPMLAPPT--L-------GI------------PQRG-----KKPI--LGLKIDKN CC1G_14241_Ccin ---IAPPAVPPPP--L-------------------------------------------- E02D9.1_Cele ------------------------------------------------R-----N--N-- F35C8.1_Cele ------------------------------------------------L-----K--N-- F35C8.2_Cele ------------------------------------------------L-----K--N-- MKK1_Scer VIAENELSGN-------SDLTP------------------------SSM-A----SPFS- MKK2_Scer VAGDSQLSERFSNLH--VDITY------------------------KELLS---SAPIS- PBS2_Scer -AGSSKVSQRMSSQV--VQASS------------------------KSTLK---NVLDNQ STE7_Scer -----------EPVLVLSSLSQ------------------------SPC-----VSSS-- 1557_Tthe ------------------------------------------------------------ 1909_Tthe ----INI--------FHSSYKILLHTTIFLFGECTFKKISLIFFFYLLL-HSSSTIPLKD 26687_Tthe -----------Q---RMTSLSL------------------------QYI-----VSPN-- Mek1_Ddis ----SSVNDRNKNKSLHSNLNP------------------------QLL-----ASPTSS 12278_Tthe -----------K---TESDV---------------------------------------- CC1G_01983_Ccin NTSFELYAGG-------PSGPP------------------------ESYM-----SP--- CC1G_14241_Ccin -KPGPSLAARMQALR--GQSTP------------------------GRRPK--------- E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------HTNTSSPYL--------- MKK2_Scer ----------------------------------------TKLSNIDTTFI--------- PBS2_Scer ET-------------QNITDVNINIDTTKITATTIGVNTGLPATDITPSVSNTASATHKA STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe QLEELKQQQHQNKDSNDKNNQKQNVEQ--------------------------------K 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ESMDFNQGFYNNNNNNNNNNNNNNLNNF-------------------------------N 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin --------------------------------------------GDDAR----------- CC1G_14241_Ccin --------------------------------------PAFSLHDIDPSLGGISDAGL-- E02D9.1_Cele ---------------------------FKLK---YN-----------------DVDGAIL F35C8.1_Cele ---------------------------GALG---Y------------------------- F35C8.2_Cele ---------------------------GALG---Y------------------------- MKK1_Scer ---------------------------------------------------RND-----L MKK2_Scer ---------------------------------------------------KKD-----L PBS2_Scer QLLNPNRRAPRRPLSTQHPTRPNVAPHKAPAIINTPKQSLSARRAVKLPPGGMS-----L STE7_Scer ---------------------------SSLS---T------------------------- 1557_Tthe ------------------------------------------------------------ 1909_Tthe ----------------------NA-------------Q------------DQKQ-----Q 26687_Tthe ---------------------------QSIG---F------------------------- Mek1_Ddis ----------------------NL-MNNGID---SPQL------------SGIS-----I 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin -----GAGRPRPPLSLHS-----------------------------------------A E02D9.1_Cele KVR---------------------------------------------G----------- F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer SNS-----------------------------V-GSD------------FS--------N MKK2_Scer DTP-----------------------------E-GEDSY----------PS--------T PBS2_Scer KMPTKTAQQPQQFAPSPSNKKHIETLSNSKVVE-GKRSN----------PG--------S STE7_Scer --PCIIDAYSNNFGL--------SP--SSTNST-PS---------TIQGLS--------- 1557_Tthe ------------------------------------------------------------ 1909_Tthe TNQSQI------Q-TDHNNNNQNSQ--NGNQQQ-GSRLNSGNIAIINSKTK--------Q 26687_Tthe -------------SK--------SP--SSKSLNLKF---------DLECLSKNKTQIEEN Mek1_Ddis STPTSSHSFNNTFTNYYNNNNNYN---NYNNNN-NSNNNNNNYNNSNNNFN--------N 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ----------------------------------TIRPG----------PA--------T CC1G_14241_Ccin AK-------PPAFA---------------------------------------------- E02D9.1_Cele -----------------------------------------ADDFEKFSE-R-------L F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer LISAYEQSSSP-IKS--------SSQPKSS---------------------SE--SY--I MKK2_Scer LLSAYDFSSSG-SNS--------APLSANN---------------------II--SC--S PBS2_Scer LINGVQSTSTSSSTEGPHDTVGTTPRTGNSNNSSNSGSSGGGGLFANFSK-Y-------V STE7_Scer ----------------------------------------------NIAT-PV-ENE--- 1557_Tthe ------------------------------------------------------------ 1909_Tthe VITKAN--------------------------ITQ------NN-LANSNVTYKTPQDQMK 26687_Tthe IIKQEK--------------------------IMD------QNLAEMFQK-LQLENK--- Mek1_Ddis FNNYNN--------------------------YGN------NNNFNNFNA-LQSSSNSSF 12278_Tthe ----------------------------------D------ILILQRFKE-LV-QQS--- CC1G_01983_Ccin IQPGGDTGTTTVPAS--------KPGASEP--------------ITRIQD-LL--RD--L CC1G_14241_Ccin -----------------------TP-------------------FANFSK-I-------V E02D9.1_Cele ENT----DE-----N-EEIVLILENISSK--NDESSGNSQNVRIFPSELQR-GKYVGNGM F35C8.1_Cele -----------------------ICV-----------SGRILSVPENLLY-GGERIGNGE F35C8.2_Cele -----------------------ICL-----------SGRNLNVPEDMLH-GGVRIGSGE MKK1_Scer DLN----S-------------------VRD-VDQLDENGWKYANLKDRIET-LGILGEGA MKK2_Scer NLI----Q-------------------GKD-VDQLEEEAWRFGHLKDEITT-LGILGEGA PBS2_Scer DIK----S------GSLNFA-GKLSLSSKG-IDF--SNGSSSRITLDELEF-LDELGHGN STE7_Scer -------HSISLPPLEESL--SPAAADLKDTLS-GT--SNGNYIQLQDLVQ-LGKIGAGN 1557_Tthe ------------------------------------------------------------ 1909_Tthe DKQASQDSA-----EN-----QYIE-------------INGNHLLISELRR-VKVLGHGS 26687_Tthe -------QN-----II-----EQLDKDMR-VVN-IL--LKNVDFKYEDFEV-VSELGKGA Mek1_Ddis DISSS--GS-----SN-----NYLNNSANN-HP-HY--DTNLSYDLKDLKI-IRVLGRGA 12278_Tthe -------NC-----FD-----EYISHDKK-IFK-IM--QKNVDFKLEDFET-ISELGRGA CC1G_01983_Ccin NLT----Q----PPPTVNPS-P-----GDSILSKIE-DPSSTQWSDECFEE-ISRLGEGA CC1G_14241_Ccin DPS----G-------ALNFS-GKAILHASG-VNF--ENGSSFAINRDQLQLDDEELGRGN E02D9.1_Cele HATVRMALHEKTQKWYVIKTILSQ-------NTDKT---EYEKEILAY-EECSQSDYVVG F35C8.1_Cele GQSAVYRL-IYNGKLIARKDVAVRLPKGVDQDSTNKLMAKKLREVNVI-NGCAPCPFIVH F35C8.2_Cele GQSAVYRL-IYNGMVIARKDVAVRLPQGGDEDSTNKLMAKRLREVNVI-NGCAPCPFIVH MKK1_Scer GGSVSKCKLKNGSKIFALKVINTL-------NTDPEYQKQIFRELQFN-RSFQ-SEYIVR MKK2_Scer GGSVAKCRLKNGKKVFALKTINTM-------NTDPEYQKQIFRELQFN-KSFK-SDYIVQ PBS2_Scer YGNVSKVLHKPTNVIMATKEVRLE--------LDEAKFRQILMELEVL-HKCN-SPYIVD STE7_Scer SGTVVKALHVPDSKIVAKKTIPVE-------QNNSTIINQLVRELSIV-KNVKPHENIIT 1557_Tthe ---------------------------------------------KVLLTQYT-HPNLIT 1909_Tthe SGLVELAVHDATGIVIGIKSIPLL--------MNSSFRKQLDQELKTL-IQCE-SDSIVK 26687_Tthe FGKVYKVCHKKDGKIYAMKEIIMV--------DDIELRQKILMEVKTL-FICQ-SPYIVT Mek1_Ddis GGVVKLAYHETSGTYIALKVITLD--------IQENIRKQIILELKTL-HKTS-YPYIVS 12278_Tthe SGRVFKVKHKETGKFYAKKEIRIN--------DDEMFQKQLIWEIKTL-FSCN-SPHIVQ CC1G_01983_Ccin GGAVHKVKDKRNGMIMARKTITTR----------EAPMKQLLRELTIM-SSTK-HVNIIT CC1G_14241_Ccin YGTVKKVLHKPTNVAMAMKEIRDS---------IQANSPAIIMELDVL-HRAV-APEIVE :: E02D9.1_Cele YHGCEVSS----IKKELVLEYMDKGDFR-------------------------------- F35C8.1_Cele FFGYYVHKYRDCVKIHIFMEEMALSA-SVLKT---EAL---------------------- F35C8.2_Cele FFGYYVHKYKDCVKIHIFMEEMALSA-SVLKK---EVL---------------------- MKK1_Scer YYGMFTDDE--NSSIYIAMEYMGGRSLDAIYK---NLL---------------------- MKK2_Scer YYGMFTDEQ--SSSIYIAMEYMGGKSLEATYK---NLL---------------------- PBS2_Scer FYGAFFIE----GAVYMCMEYMDGGSLDKIYD---ESS---------------------- STE7_Scer FYGAYYNQHI-NNEIIILMEYSDCGSLDKILSVYKRFV---------------------- 1557_Tthe CFGAYYEE----GTIKIILELMDFGSIRNLID---M------------------------ 1909_Tthe CYGAYIQK----CMINITLEYMDLGTVHDLVK---K------------------------ 26687_Tthe YYGAFYTE----GKLHIILEYMDVGTLDSLLK---K------------------------ Mek1_Ddis FYDAFYTE----GSIFIALEFMELGSLSDIMK---K------------------------ 12278_Tthe YYCAFYTE----CMLHLILEYMDMGTLDTILK---K------------------------ CC1G_01983_Ccin FYGAYMSPS--SSEIKIIMEYCEGGSLESVGK---RIR---------------------- CC1G_14241_Ccin FYGAFFIE----SCVYYCMEYMDAGSLDKLIQ---SNSQPPQPQIPKPPSSDPIQTDASS . :* E02D9.1_Cele -----------------------------------------P------FGILPFSVHQ-- F35C8.1_Cele ----------------------------------------KQ------GGAIPEFVIG-- F35C8.2_Cele ----------------------------------------KR------GGIVPEFVIG-- MKK1_Scer ----------------------------------------ER------GGRISEKVLG-- MKK2_Scer ----------------------------------------KR------GGRISERVIG-- PBS2_Scer -----------------------------------------E------IGGIDEPQLA-- STE7_Scer ----------------------------------------QRGTVSSKKTWFNELTIS-- 1557_Tthe ------------------------------------------------LKEINYCYLSKI 1909_Tthe ------------------------------------------------VGPLPEIIVA-- 26687_Tthe -----------------------------------------A------GGKVSEVVLK-- Mek1_Ddis ------------------------------------------------TSTIPEPVLG-- 12278_Tthe ------------------------------------------------TKQVSEPILI-- CC1G_01983_Ccin ----------------------------------------ER------GAIVGEKIAG-- CC1G_14241_Ccin PEYSFAMPFVEEDLDLTKDENFEPYNRAFNRTCPPPIPSTYS------GGPIPEAILG-- . E02D9.1_Cele ----------SVALSLIRAIRHVWNSGPGYIHRDIKPENILVN-SQGYVKICDFGAAKRI F35C8.1_Cele ----------RIVCSVIHAMWFLKD-RLQIIHRDIKPGNILID-YDGRVKICDFGICGIL F35C8.2_Cele ----------RIACSVIHAMWFLKE-KMQIIHRDIKPGNILID-YDGRVKICDFGISGIL MKK1_Scer ----------KIAEAVLRGLSYLHE-K-KVIHRDIKPQNILLN-ENGQVKLCDFGVSGEA MKK2_Scer ----------KIAESVLRGLSYLHE-R-KVIHRDIKPQNILLN-EKGEIKLCDFGVSGEA PBS2_Scer ----------FIANAVIHGLKELKE-QHNIIHRDVKPTNILCSANQGTVKLCDFGVSGNL STE7_Scer ----------KIAYGVLNGLDHLYR-QYKIIHRDIKPSNVLIN-SKGQIKLCDFGVSKKL 1557_Tthe LCNQKYQYHFFILKQLLKGLEFLHK-ERHQVHRDIKPENILIN-KRGNVKLTDFGISKQL 1909_Tthe ----------IMAIQVLKGLDYIHN-KAKVIHRDIKPSNLLVN-SKGQVKIADFGVSANL 26687_Tthe ----------YLTYQILKGLKYLHK-DLHIIHRDIKPGNILVN-SKGEIKISDLGICGAI Mek1_Ddis ----------KIAFQVLQGLVYLHR-KLHLIHRDIKPSNILVN-NKGEAKIADFGVSGQL 12278_Tthe ----------YTTYQIIKGIHYLHK-DLKIIHRDLKPGNILVN-SEGEIKISDLGICGKV CC1G_01983_Ccin ----------RLAEGVLQGLSYLHS-K-KTIHRDIKPSNILLS-KEGVVKLCDFGVSGEL CC1G_14241_Ccin ----------RIAASMVRGLKFLKD-ELNIIHRDVKPTNVLVN-CKGQVKLCDFGVSGQL ::..: : :***:** *:* . * *: *:* . E02D9.1_Cele DNTYRIASSAAGTQMYQAPEQQMGQ----------------------------------- F35C8.1_Cele ENSI--AVSDTGCQQYTAPEILVKGV-------------------------------SNS F35C8.2_Cele QDSI--AVSATGCQQYTAPEINELAM-------------------------------VHS MKK1_Scer VNSL--ATTFTGTSFYMAPERIQGQ----------------------------------- MKK2_Scer VNSL--AMTFTGTSFYMAPERIQGQ----------------------------------- PBS2_Scer VASL--AKTNIGCQSYMAPERIKSLN-------------------------------PDR STE7_Scer INSI--ADTFVGTSTYMSPERIQGN----------------------------------- 1557_Tthe EKTQQLCMTYVGTTLYMSPERLIGN----------------------------------- 1909_Tthe ESAVE-VKNWVGTVTYMSPERFRGQ----------------------------------- 26687_Tthe NATLDERQTFVGTSIYMSPERLSGE----------------------------------- Mek1_Ddis QHTLSKAVTWVGTVTYMSPERISGR----------------------------------- 12278_Tthe NGTMDQKNTFVGTTIYMSPERLNGD----------------------------------- CC1G_01983_Ccin ILSQ--AGTFTGTSFYMAPERIQGK----------------------------------- CC1G_14241_Ccin DKSM--AKTNIGCQSYMAPERIRGESRVVGAVPASEGGTGTAAAAQGGVPGTAALADELY : . * * :** E02D9.1_Cele -DYSEKVDIWCFGLTLWEFAIGPNLE---EYL---------------------------- F35C8.1_Cele PGYSIKSDIWSLGITIFELATLRYPYPVG------------------------------- F35C8.2_Cele PGYSIKSDIWSLGITIFELATL-------------------------------------- MKK1_Scer -PYSVTSDVWSLGLTILEVANGKFPCSSEKMA---------------------------- MKK2_Scer -PYSVTCDVWSLGLTLLEVAGGRFPFESDKIT---------------------------- PBS2_Scer ATYTVQSDIWSLGLSILEMALGRYPYPPETY----------------------------- STE7_Scer -VYSIKGDVWSLGLMIIELVTGEFPLGGHND----------------------------- 1557_Tthe -QYGLRSDIWSVGLVIIELATGLYPYDVKN------------------------------ 1909_Tthe -AYTANTDIWSLGLTICECALGTYPYFDSNQYEK-------------------------- 26687_Tthe -SYSVKTDIWSFGLLLLEFSESKNPLQLNE------------------------------ Mek1_Ddis -SYSFDSEIWSLGLTILECAIGKFPYGSNLPHQQQQPLQQQQQQQQQQQQPLQQQQQQQQ 12278_Tthe -SYTMKTDIWSVGLLLIEFSEGKHPIQASN------------------------------ CC1G_01983_Ccin -EYTIRSDVWSTGISLLELVQNRFPFPPD------------------------------- CC1G_14241_Ccin GAYTVSSDVWSLGLSIIELGLGRYPYPPETY----------------------------- * ::*. *: : * E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe ------------------------------------------------------------ 26687_Tthe ------------------------------------------------------------ Mek1_Ddis QQQQPLQLQLQNLDINNSNNNIRNSNNNNNNNNNNNNNNNNNNNNNVLDISNGGLVDSGS 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ---NG---LSSYEEITV--------EP--------------------------------- F35C8.1_Cele -----FSEFTLLSAIVTTPAPYLER----------------------------------- F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ---ANIAPFELLMWILTFT-PELKDEP---------------E----------------- MKK2_Scer ---QNVAPIELLTMILTFS-PQLKDEP---------------E----------------- PBS2_Scer -----DNIFSQLSAIVDGPPPRLPS----------------------------------- STE7_Scer ---TPDGILDLLQRIVNEPSPRLPK----------------------------------- 1557_Tthe -----KSIVQFVSNILQSKEPTLPD----------------------------------- 1909_Tthe --KENLSFWELLEYFNMKPAPRLPE----------------------------------- 26687_Tthe ----NASFFEILAKVMNFSIPELNS----------------------------------- Mek1_Ddis SVPEGMGFWVLLDCIVKEEVPILPS----------------------------------- 12278_Tthe ------NFFEVLNNIIDFKIPPLKN----------------------------------- CC1G_01983_Ccin -----LPPIELMMYITNSEPPRLEDEP--------------------------------- CC1G_14241_Ccin -----SNVFAQLTAIVHGPPPCLPSGPPPPLSPDDDSSFEEPVLPPTLDDQDPLISPTTG E02D9.1_Cele --IDGFPESLAVLISNCLRRQPSARWNADQIE----------QSDYLRDLPEPNR-QSVA F35C8.1_Cele ---VTF------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer -SNIIWSPSFKSFIDYCLKKDSRERPSPRQMI----------NHPWIKGQMKKNV--NME MKK2_Scer -LDISWSKTFRSFIDYCLKKDARERPSPRQML----------KHPWIVGQMKKKV--NME PBS2_Scer ---DKFSSDAQDFVSLCLQKIPERRPTYAALT----------EHPWLVKYRNQDV--HMS STE7_Scer --DRIYSKEMTDFVNRCCIKNERERSSIHELL----------HHDLIMKYVSPSKDDKFR 1557_Tthe --NGKYSAALMDFVKKCVAKEQKDRLDISDLL----------KHEWITQYNMADD--KQI 1909_Tthe ----NYSEEMKDFVAKCFKKSPLDRPHSHDLL----------NHEMVKKFSQYDSS-YFE 26687_Tthe ----IKSKEFIQFVEQCTKINPKERADVVQLL----------ELPFVKTCHGKTA--KLQ Mek1_Ddis ----TFSKEFRSFISECLQKEPTERPTASNLL----------NHEFVKKYQNFNVE---- 12278_Tthe ----INSPEFTNFIEICLKSDQNERADITQLLVNTTSFSSFNEHPFLRKIKGKTA--QLK CC1G_01983_Ccin --GVNWSEEMKDFIKQALTVDPVDRPTPKDML----------EHPWIKNMMKYEN--TMG CC1G_14241_Ccin RQRPGYSPFARDWVNKCMRKDAKERATYKELL----------EHPWLIRNGQVDV--DME E02D9.1_Cele NFVN-------------------------------------------------------- F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer KFVRKC------------------------------------------------------ MKK2_Scer RFVKKCWE---------------------------------------------------- PBS2_Scer EYITERLERRN-------------------------------------------K----- STE7_Scer HWCRKIKSKIKEDK----------------------------------------R----- 1557_Tthe NLLQQYLQHLE------------------------------------------------- 1909_Tthe EWITKNNLKPAQDKYEPAPVVSTVQNTPYFSHQNPPNQTQQTSNQSYQQIKNHDQINLNQ 26687_Tthe PIFVKW------------------------------------------------------ Mek1_Ddis KW---------------------------------------------------------- 12278_Tthe PFFVNW------------------------------------------------------ CC1G_01983_Ccin RWIAQVWGW-S-------------------------------------------R----- CC1G_14241_Ccin GWVRCALDAKE------------------------------------------------- E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe QHNQQNQNGSIQVQQGQNNLSIQQLNSTFRKNSQVQNQQNPVQQQQQQQQQQQLQQNINQ 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe SNIQQQIVQQQVNSQSQQQVQNLIALQQNQQQQQQQQQIQQQQQQMSSQALNSQQLHINT 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe NLANQNKSNNNSIYQISPTIHTFRPNQEQESENAQEVDEFINDPNEFYGPSDNKTKGIVH 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe QRISSLSDKLAPAAPTAATNTSNSRKSSQILNCNFQEMTITSNEIVDSINSPLPIETSIQ 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe NPQIPNQQQNSNSRIKQFQIKNPTNLNIQQINQDNLQRSNQSQIITQQDQNQQNASQNQP 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe IIQKQNIGHHYSASISIGQQQRNSNTPRTSLQYVNNGVQMVQVGYDRMNNSIGVSQIVSP 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe QSQLNSQKVSPSQAAEQFQQTASNQMHGNLNSNQSQSVYLQQQHILQQQQFQLNLQKIEQ 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe VTGGASQNNTPKLITPLASSSINNNIQQAQNNYQINNQAQNIDNVVQINPNQQQKFSVPD 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe AQQNINMAPQSNQLAQTKANNLNSQPALELNEANLQQIQSEYYESINNQYDIALIQGVNG 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe NLIANQIQEIGQLQNQQYQQQPQQIQYQQINNYSLPPKPLSNQKINTPSNQAHSLSIQKQ 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe NSVGSAVNQQVYQNQINQKIIQNQNAANLHQQQLIVQQNIQQQQQLISNQLQQQNSPDYS 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe NQFNQIQYQQQNQGMQQFQNMVNKINQQQIVVSQQLIQSQNMAFYQQSQNLTNYNPSVRN 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe IIQSEDLQTEVHKRIEEDHLKLKQLITNDFSQKFVDNLLNSLQIRVKQKIFEQLSSLIEK 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe EYQIEFQVLMNNITNQLFQPPQIQQQQQQQIIQQNAQTQSNQSYQFPPAFINQPSNAFPQ 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe QQQVQLQQVTQMQANPQLNINGPLIVNGPEQIPQQVQQIPNNAAATAIRINTNLPQDKNS 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe NTQNSTPLSYKSGSPKQNNSSPITINQNNNLSKQIASQKQNEMQAPQNQQFQQINQANQS 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe TQDQKAVNNNLSINQIQSNTNQITSNNHDELNAQQKLVPQSQNARQVQQPLPIDIVTTQE 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe QQQTQQQSIQQQQLLLQQQQQQFMTQSQDVFARERTKQFSQTPQNQATQNVNKNGSYTTS 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe HQQQVQQQKAPSQFNKNATISDDPNKATDFELSKAIQKQLGEQKSTLNQPHTQQQKQQAN 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe QVKENDLQFQDQIDLQDNSSGAHPHAATTCPHQATINQLQQSSNNPPQIVNNPNSSKSKL 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe AHQGSNNIENTNNFNNIQHGQQINILNDEVNDTEISVSNNISNDTSPINDEELLPNPVLK 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ------------------------------------------------------------ STE7_Scer ------------------------------------------------------------ 1557_Tthe ------------------------------------------------------------ 1909_Tthe QNYISTSAQNSQNDHNLQQIVAGNGNQSQSQSNINVNIVGLPKRLTRESIIINNPQQQAE 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ------------------------------------------------------------ CC1G_14241_Ccin ------------------------------------------------------------ E02D9.1_Cele ------------------------------------------------------------ F35C8.1_Cele ------------------------------------------------------------ F35C8.2_Cele ------------------------------------------------------------ MKK1_Scer ------------------------------------------------------------ MKK2_Scer ------------------------------------------------------------ PBS2_Scer ---------------------------------ILR---ERGENGLSKNV---------- STE7_Scer ---------------------------------IKR---EALDRA-KLEK---------- 1557_Tthe -----------------------------------L---SYYQFK-QAQA---------- 1909_Tthe LAQNINQQQPAAASQGQIPQQTVNQKVIPVSPNFNSEEAETSKKK-PQFADGTKVVINIQ 26687_Tthe ------------------------------------------------------------ Mek1_Ddis ------------------------------------------------------------ 12278_Tthe ------------------------------------------------------------ CC1G_01983_Ccin ---------------------------------SKK---SRDE---SSSR---------- CC1G_14241_Ccin ----------------------------------------R------------------- E02D9.1_Cele ---NYYQR F35C8.1_Cele ----SNNY F35C8.2_Cele -------T MKK1_Scer -----WKD MKK2_Scer --KEKDGI PBS2_Scer PALHMGGL STE7_Scer KQSERSTH 1557_Tthe QQAEEQQQ 1909_Tthe EQNQIKKK 26687_Tthe --LTIMNE Mek1_Ddis TANLKQQQ 12278_Tthe --MKVVEK CC1G_01983_Ccin PGTASGTP CC1G_14241_Ccin -AKAGRGR