CLUSTAL W (1.83) multiple sequence alignment TGFbR2_Hsap MGRGLLR-GLW---------P--------LH-I-VLWTR--I--ASTIPPHVQKSDVEME MISR2_Hsap MLGSLG-----------------------------LWALLPT-----AVEAP-------- MISR2_Mmus MLGTLG-----------------------------LWTLLPA-----AAQVS-------- BMPR2_Mmus MTSSLHR-PF----------R--------VP-W-LLWAVLLVST---TAASQ-------- ACTR2B_Mmus MTAPW-A----------------------------ALALLWGSLCAGSGRGE-------- ACTR2_Mmus MGAAAKL----------------------------AFAVFLISCSSGAILGR-------- daf-4_Cele MNQKGTV-RLK---------A--------LV-L-ICLPLFLIATPVPVAVTE-------- BMPR2_Hsap MTSSLQR-PW----------R--------VP-W-LPWTILLVST---AAASQ-------- put_Dmel MSKYDLL-YLT---------A--------Q----LTLVCCLIGIHGSILPGS-------- wit_Dmel MNWAIY----------------------------LLLALISLGR---ATPVP-------- TGFBR2_Mmus MGRGLLR-GLW---------P--------LH-I-VLWTR--I--ASTIPPHVPKSDVEME ACTR2B_Hsap MTAPW-V----------------------------ALALLWGSLCAGSGRGE-------- ACTR2_Hsap MGAAAKL----------------------------AFAVFLISCSSGAILGR-------- TGFbRII_Spur MAYDVET-DEN---------N--------VP-F-VVTVS--LGVASAFEC-LDCSEVPVE ACTR2_Spur MAGKDPLIRLC---------E--------LFLF-LSIAVLLVE--GASVNLP-------- BMPR2_Spur MHSSEHG-DY----------T--------GK-V-I--SVITIEA---EIAEL-------- AqueK683_Aque MAELRIL----------------------------VFCLLALLLPVPSYLLV-------- AqueK684_Aque MCVYLKT---S---------D------------------VFIKCFSTACPGG------AD AqueK685_Aque MINVTLF-IDPPDEAENAPSSFHVTDQITSS-IEPSLSMIPS-T---VPAPS-------- AqueK686_Aque MVAVLRV-VL-------------------------CFCLLST-I---VTAFQ-------- * TGFbR2_Hsap AQKDEIICPSCNRTAHPLRHINNDMIVTDNNGAVKFP----------------------- MISR2_Hsap ----------------------------------PNR----------------------- MISR2_Mmus ----------------------------------PNR----------------------- BMPR2_Mmus ----------------------------------NQE----------------------- ACTR2B_Mmus ----------------------------------AET----------------------- ACTR2_Mmus ----------------------------------SET----------------------- daf-4_Cele ----------------------------------DDRQDRIESEAAEKEWANTLVSKVAQ BMPR2_Hsap ----------------------------------NQE----------------------- put_Dmel ----------------------------------HGI----------------------- wit_Dmel ----------------------------------NRQ----------------------- TGFBR2_Mmus AQKDASIHLSCNRTIHPLKHFNSDVMASDNGGAVKLP----------------------- ACTR2B_Hsap ----------------------------------AET----------------------- ACTR2_Hsap ----------------------------------SET----------------------- TGFbRII_Spur CDAE-------------------------------------------------------- ACTR2_Spur ----------------------------------LGS----------------------- BMPR2_Spur ------------------------------------------------------------ AqueK683_Aque ----------------------------------CYT----------------------- AqueK684_Aque ICIELCPEGINKCHTVRRTNSYPVEMRCTNTPSCSQS----------------------- AqueK685_Aque ----------------------------------NTL----------------------- AqueK686_Aque ----------------------------------CRV----------------------- TGFbR2_Hsap -----------------------------QLCK--------------------------- MISR2_Hsap -----------------------------RTCV--------------------------- MISR2_Mmus -----------------------------RTCV--------------------------- BMPR2_Mmus -----------------------------RLCA--------------------------- ACTR2B_Mmus -----------------------------RECI--------------------------- ACTR2_Mmus -----------------------------QECL--------------------------- daf-4_Cele SNGTGTIKVSAPAKPTLRRMDNEEDEVISIECV--------------------------- BMPR2_Hsap -----------------------------RLCA--------------------------- put_Dmel -----------------------------IECE--------------------------- wit_Dmel -----------------------------YSCM--------------------------- TGFBR2_Mmus -----------------------------QLCK--------------------------- ACTR2B_Hsap -----------------------------RECI--------------------------- ACTR2_Hsap -----------------------------QECL--------------------------- TGFbRII_Spur ------------------------------SCV--------------------------- ACTR2_Spur -----------------------------THCH--------------------------- BMPR2_Spur ------------------------------------------------------------ AqueK683_Aque -----------------------------DDCP--------------------------- AqueK684_Aque -----------------------------SDCVFETLQNFHSLHYCCCTGDLCNRLDNYT AqueK685_Aque -----------------------------RSHS--------------------------- AqueK686_Aque -----------------------------NSCI--------------------------- TGFbR2_Hsap -----------------------------FCDV-RFST----C-D---NQK--------- MISR2_Hsap -----------------------------FFEA-PGVR-----GSTKTLGELL--DTGT- MISR2_Mmus -----------------------------FFEA-PGVR-----GSTKTLGEMV--DAGP- BMPR2_Mmus -----------------------------FKDP-YQQD----L-G---IGE--------- ACTR2B_Mmus -----------------------------YYNA-NWEL----E-RTN---Q--------- ACTR2_Mmus -----------------------------FFNA-NWER----D-RTN---Q--------- daf-4_Cele -----------------------------YYDEMECEK----S-GD-C--E--------- BMPR2_Hsap -----------------------------FKDP-YQQD----L-G---IGE--------- put_Dmel -----------------------------HFDEKMCNT----T-QQ-C--E--------- wit_Dmel -----------------------------SYQE-DDNSFHDDDGDQDSSGELQ--EQQV- TGFBR2_Mmus -----------------------------FCDV-RLST----C-D---NQK--------- ACTR2B_Hsap -----------------------------YYNA-NWEL----E-RTN---Q--------- ACTR2_Hsap -----------------------------FFNA-NWEK----D-RTN---Q--------- TGFbRII_Spur -----------------------------P------IS----C-T---TSV--------- ACTR2_Spur -----------------------------LYSSQECEK----D-GTKC--G--------- BMPR2_Spur -----------------------------YTET-FI------------------------ AqueK683_Aque -----------------------------YDNNL-L-C----Y-KTC---T--------- AqueK684_Aque DSVDPILNVTSAIPTVPVPVRPSDVLICERYNC-SFND----D-GI-C--Y--------- AqueK685_Aque ------------------------------------------------------------ AqueK686_Aque -----------------------------RCSS-SSPV-----DCTVTPVDQYSYNYYCE TGFbR2_Hsap ----SCMSNCSI-TSICEKPQEVCVAVW-RKN---DENIT------------LE---TVC MISR2_Hsap --------ELPR-AIRCL-YSRCCFGIW-NLT---QDRAQ------------VE--MQGC MISR2_Mmus --------GPPK-GIRCL-YSHCCFGIW-NLT---HGRAQ------------VE--MQGC BMPR2_Mmus ----SRISHENG-TILCS-KGSTCYGLW-EKS---KGDIN------------LV--KQGC ACTR2B_Mmus ----SGLERCEG---EQD-KRLHCYASW-RNS---SGTIE------------LV--KKGC ACTR2_Mmus ----TGVEPCYG---DKD-KRRHCFATW-KNI---SGSIE------------IV--KQGC daf-4_Cele ----ITKKTCYS---EAHLKAVGCLAVF-GLPT---QEINSTEPYLKVDKPQYK--SLGC BMPR2_Hsap ----SRISHENG-TILCS-KGSTCYGLW-EKS---KGDIN------------LV--KQGC put_Dmel ----TRIEHCKM---EAD-KFPSCYVLW-SVN-ETTGILR------------IK--MKGC wit_Dmel --ESTPIPSEPH-RRTCPDGYTFCFTIW-NQT---ANGAR------------VV--KQGC TGFBR2_Mmus ----SCMSNCSI-TAICEKPHEVCVAVW-RKN---DKNIT------------LE---TVC ACTR2B_Hsap ----SGLERCEG---EQD-KRLHCYASW-RNS---SGTIE------------LV--KKGC ACTR2_Hsap ----TGVEPCYG---DKD-KRRHCFATW-KNI---SGSIE------------IV--KQGC TGFbRII_Spur ----PCVGYCLI-ATFPDMTSSSMTNGS-DPS---SQNIN------------GM---FAC ACTR2_Spur ----NTTEECDN---KEA-EIPSCYVLW-KNETSSGGGVD------------VM--MRGC BMPR2_Spur -----------------------------NIS---RLHQS------------LY--IQGC AqueK683_Aque ----PSSNSCVR---IAA-ID--------RSN---FPPAR------------IIFQEFGC AqueK684_Aque ----HGYEVCPETFSSNP-DDHSCIATY-HKN-PTTNLIE------------LM--YKGC AqueK685_Aque ---------------------------F-DES---TGTIR------------SV---TGF AqueK686_Aque APSHCTPQNVPG---SNR-DGYYCYASLFIRN---LNSTD------------F----DGH TGFbR2_Hsap ------------------------------------------------------------ MISR2_Hsap ------------------------------------------------------------ MISR2_Mmus ------------------------------------------------------------ BMPR2_Mmus ------------------------------------------------------------ ACTR2B_Mmus ------------------------------------------------------------ ACTR2_Mmus ------------------------------------------------------------ daf-4_Cele MPYQ-------------------------------------------------------- BMPR2_Hsap ------------------------------------------------------------ put_Dmel ------------------------------------------------------------ wit_Dmel ------------------------------------------------------------ TGFBR2_Mmus ------------------------------------------------------------ ACTR2B_Hsap ------------------------------------------------------------ ACTR2_Hsap ------------------------------------------------------------ TGFbRII_Spur ------------------------------------------------------------ ACTR2_Spur ------------------------------------------------------------ BMPR2_Spur ------------------------------------------------------------ AqueK683_Aque ------------------------------------------------------------ AqueK684_Aque RHNRLPNPLTLQACSNSTSMCHIDNPLVSDQDSAVYYCCCGESLCNQNITFTHPTQVSTY AqueK685_Aque ------------------------------------------------------------ AqueK686_Aque ------------------------------------------------------------ TGFbR2_Hsap ------------------------------------------------------------ MISR2_Hsap ------------------------------------------------------------ MISR2_Mmus ------------------------------------------------------------ BMPR2_Mmus ------------------------------------------------------------ ACTR2B_Mmus ------------------------------------------------------------ ACTR2_Mmus ------------------------------------------------------------ daf-4_Cele ------------------------------------------------------------ BMPR2_Hsap ------------------------------------------------------------ put_Dmel ------------------------------------------------------------ wit_Dmel ------------------------------------------------------------ TGFBR2_Mmus ------------------------------------------------------------ ACTR2B_Hsap ------------------------------------------------------------ ACTR2_Hsap ------------------------------------------------------------ TGFbRII_Spur ------------------------------------------------------------ ACTR2_Spur ------------------------------------------------------------ BMPR2_Spur ------------------------------------------------------------ AqueK683_Aque ------------------------------------------------------------ AqueK684_Aque DIDECAINNGGCSETCINTPGNYSCECNAGRYLSPHSGRCEDNDGIICLYRNCTLDGSCH AqueK685_Aque ------------------------------------------------------------ AqueK686_Aque ------------------------------------------------------------ TGFbR2_Hsap --------------------------------------------HDPKLPYHDFILEDAA MISR2_Hsap --------------------------------------------RDSDE-------PGCE MISR2_Mmus --------------------------------------------RDSDE-------PGCE BMPR2_Mmus --------------------------------------------WSHIGDP-----QECH ACTR2B_Mmus --------------------------------------------WLDDF-------NCYD ACTR2_Mmus --------------------------------------------WLDDI-------NCYD daf-4_Cele --------------------------------------------HADSM-------NCEN BMPR2_Hsap --------------------------------------------WSHIGDP-----QECH put_Dmel --------------------------------------------FTDMH-------EC-N wit_Dmel --------------------------------------------WKDNTDRT----SICS TGFBR2_Mmus --------------------------------------------HDPKLTYHGFTLEDAA ACTR2B_Hsap --------------------------------------------WLDDF-------NCYD ACTR2_Hsap --------------------------------------------WLDDI-------NCYD TGFbRII_Spur --------------------------------------------INETNP------EIGG ACTR2_Spur --------------------------------------------WQNQG-------DCLD BMPR2_Spur --------------------------------------------WGNEAKS-----LNCN AqueK683_Aque ----------------------------------------------SSL-------RCNT AqueK684_Aque TNTTEHCASSHLISDDLRTETHLHYCVALFHFINGTFYPNTQSCFAGSH-------SSCQ AqueK685_Aque --------------------------------------------TT---SLT-----SI- AqueK686_Aque --------------------------------------------WFSFFQVE-----SCE TGFbR2_Hsap -------SPKCIMKE--K----KKPGETFFMCSCSSDECN-------------------- MISR2_Hsap -------SLHCDPSPRAH----PSPGSTLFTCSCGTDFCN-------------------- MISR2_Mmus -------SLHCDPVPRAH----PNPSSTLFTCSCGTDFCN-------------------- BMPR2_Mmus -------YEECVVTTTPP----SIQNGTYRFCCCSTDLCN-------------------- ACTR2B_Mmus -------RQECVATEE---------NPQVYFCCCEGNFCN-------------------- ACTR2_Mmus -------RTDCIEKKD---------SPEVYFCCCEGNMCN-------------------- daf-4_Cele -------ESSCRQGR--------SFRGGIGMCCCSTNNCN-------------------- BMPR2_Hsap -------YEECVVTTTPP----SIQNGTYRFCCCSTDLCN-------------------- put_Dmel -------QTECVTSAE------P-RQGNIHFCCCKGSRCN-------------------- wit_Dmel -------QSECTS--SAP----TSKTSSLYYCCCSGGVCN-------------------- TGFBR2_Mmus -------SPKCVMKE--K----KRAGETFFMCACNMEECN-------------------- ACTR2B_Hsap -------RQECVATEE---------NPQVYFCCCEGNFCN-------------------- ACTR2_Hsap -------RTDCVEKKD---------SPEVYFCCCEGNMCN-------------------- TGFbRII_Spur -------KKHCQAHPDDY----SYAAEGSYSCSCASDGCN-------------------- ACTR2_Spur -------MDYCMSSSP--------ADQNLFFCCCVGNLCN-------------------- BMPR2_Spur -------QENCTAHSKPSEYLVRTKNQTSRICCCAGDYCN-------------------- AqueK683_Aque -------RDLLCS---------PNITDLTQHCCCTGDRCNNPGGRADALAELMKPKFSYH AqueK684_Aque -------NTNCTLTNITR----LSHNNDVYSCCCYGDLCN-------------------- AqueK685_Aque -----EHSSSRI-I--SS----IP-QSTNSLT---------------------------- AqueK686_Aque EAAGSELTDDCLSITKRV----SSLEGTNIFCRCTEDNCQ-------------------- TGFbR2_Hsap ---------------------------------------------------DNII-FSE- MISR2_Hsap ---------------------------------------------------ANYS-HL-- MISR2_Mmus ---------------------------------------------------ANYS-HL-- BMPR2_Mmus ---------------------------------------------------VNFT-EN-- ACTR2B_Mmus ---------------------------------------------------ERFT-HL-- ACTR2_Mmus ---------------------------------------------------EKFS-YF-- daf-4_Cele ---------------------------------------------------MPDLIEM-- BMPR2_Hsap ---------------------------------------------------VNFT-EN-- put_Dmel ---------------------------------------------------SNQK-YI-- wit_Dmel ---------------------------------------------------AQYS-VV-- TGFBR2_Mmus ---------------------------------------------------DYII-FSE- ACTR2B_Hsap ---------------------------------------------------ERFT-HL-- ACTR2_Hsap ---------------------------------------------------EKFS-YF-- TGFbRII_Spur ---------------------------------------------------KVLY-TAEA ACTR2_Spur ---------------------------------------------------MNFS-FL-- BMPR2_Spur ---------------------------------------------------RNVS-DAY- AqueK683_Aque LSPPNEPVPSTEPGCSVANTSDITPDCIIDVPFIGALKNEYTCYCNESLCNINES-IT-- AqueK684_Aque ---------------------------------------------------ERGL-IF-- AqueK685_Aque --------------------------------------------------------SVST AqueK686_Aque ---------------------------------------------------DIFN-VTII TGFbR2_Hsap ---EYNT-S--------------------------------------------------- MISR2_Hsap PPP-GSP-G--------------------------------------------------- MISR2_Mmus PPS-GNQ-G--------------------------------------------------- BMPR2_Mmus FPP-PDT----------------------------------------------------- ACTR2B_Mmus PEP-GGP----------------------------------------------------- ACTR2_Mmus PEM-EVT----------------------------------------------------- daf-4_Cele VNP-SLK----------------------------------------------------- BMPR2_Hsap FPP-PDT----------------------------------------------------- put_Dmel KST---T----------------------------------------------------- wit_Dmel EPA-PLELG--------------------------------------------------- TGFBR2_Mmus ---EYTT-S--------------------------------------------------- ACTR2B_Hsap PEA-GGP----------------------------------------------------- ACTR2_Hsap PEM-EVT----------------------------------------------------- TGFbRII_Spur TIPEEPT-V--------------------------------------------------- ACTR2_Spur PTP-EP------------------------------------------------------ BMPR2_Spur VPL-PST----------------------------------------------------- AqueK683_Aque HPT-RLS-SYGFKECLSYNCEYNCNIVNNTNINCSCPAGFIAIGFTRCRDVNECLVSNGG AqueK684_Aque PDF-NAT----------------------------------------------------- AqueK685_Aque RS--STE----------------------------------------------------- AqueK686_Aque IDP-PNDVS-------------------------------------------SSTLINGV TGFbR2_Hsap ------------------------------------------------------------ MISR2_Hsap -------------------------------------------------TP-G------- MISR2_Mmus -------------------------------------------------AP-G------- BMPR2_Mmus -------------------------------------------------TP-L------- ACTR2B_Mmus -------------------------------------------------EV-T------- ACTR2_Mmus -------------------------------------------------QP-T------- daf-4_Cele -------------------------------------------------KD-S------- BMPR2_Hsap -------------------------------------------------TP-L------- put_Dmel -------------------------------------------------EA-T------- wit_Dmel -------------------------------------------------SNEG-R----- TGFBR2_Mmus ------------------------------------------------------------ ACTR2B_Hsap -------------------------------------------------EV-T------- ACTR2_Hsap -------------------------------------------------QP-T------- TGFbRII_Spur -------------------------------------------------PP-S------- ACTR2_Spur -------------------------------------------------TP-T------- BMPR2_Spur -------------------------------------------------KP-T------- AqueK683_Aque CQQTCVNTIGSYYCECFDGYFFDSRTLSCLSKFANFYCSHYSDDDIRLTEI-T------- AqueK684_Aque -------------------------------------------------SP-I------- AqueK685_Aque -------------------------------------------------SV-LV------ AqueK686_Aque ITS----------------------------------------------SP-SPPSVYSS TGFbR2_Hsap --------------------------------------------------NP------DL MISR2_Hsap ---------------------------------------------------S------QG MISR2_Mmus ---------------------------------------------------P------QE BMPR2_Mmus -------------------------------------------------SPP------H- ACTR2B_Mmus -------------------------------------------------YEP------PP ACTR2_Mmus -------------------------------------------------SNP------VT daf-4_Cele ---------D-------N-------------------------SALLWASTP------SN BMPR2_Hsap -------------------------------------------------SPP------H- put_Dmel -------------------------------------------------TQV------PK wit_Dmel -------------------------------------------------TSI------TN TGFBR2_Mmus --------------------------------------------------SP------DL ACTR2B_Hsap -------------------------------------------------YEP------PP ACTR2_Hsap -------------------------------------------------SNP------VT TGFbRII_Spur -------------------------------------------------SEP------DA ACTR2_Spur -------------------------------------------------VTQ------TT BMPR2_Spur -------------------------------------------------VTQ------YK AqueK683_Aque -------------------------------------------------ENTKIGSLDCT AqueK684_Aque -------------------------------------------------PMS------ST AqueK685_Aque --------------------------------------------------PS------ST AqueK686_Aque VPLSLSLSSSTIDLTTSSVSFSINTSPTLITVTNTHTTGILTTSSV---VPS------ST TGFbR2_Hsap L-----------------------L----------------------------------- MISR2_Hsap P-----------------------Q-A---------------AP---------------- MISR2_Mmus P-----------------------Q-A---------------TP---------------- BMPR2_Mmus ------------------------------------------------------------ ACTR2B_Mmus ------------------------------------------------------------ ACTR2_Mmus ------------------------------------------------------------ daf-4_Cele M-----DL----------------E-----------------SL---------------- BMPR2_Hsap ------------------------------------------------------------ put_Dmel E-------------------------K---------------TQ---------------- wit_Dmel R-----------------------A-T---------------EK---------------- TGFBR2_Mmus L-----------------------L----------------------------------- ACTR2B_Hsap ------------------------------------------------------------ ACTR2_Hsap ------------------------------------------------------------ TGFbRII_Spur T-----------------------PTK---------------TKGPPIENTDPNKTEEGR ACTR2_Spur V--TGSNID---------------E-K---------------KK---------------- BMPR2_Spur V-----------------------I-S---------------DQ---------------- AqueK683_Aque P-VQSCFAQLMYSHHHWYLNAMTCG-Q---------------SP---------------- AqueK684_Aque SLMASSDS------------------ITIFLSSSPYVSATQTAS---------------- AqueK685_Aque -------------------------------------------V---------------- AqueK686_Aque G-----------------------V-----------------IP---------------- TGFbR2_Hsap -------VIFQV-TG---ISLLPPLGVAI---SV-I-IIFYCY-RVNRQQKLS------- MISR2_Hsap ----GESIWMAL-VL---LGLFLLLLLLL---GS--IILALLQ---RKNYRVRGE--P-- MISR2_Mmus ----GGPVWMAL-LL---LGMFLVL--LL---SS--IILALLQ---RKACRVQGG--S-- BMPR2_Mmus -----SFNRDET-II---IALASVSVLAV---LI--VALCFGY-RMLTGDRKQG---L-- ACTR2B_Mmus ----TAPTLLTV-LA---YSLLPIGGLSL---IV-LL-AFWMY-RHRKPPYGHVD--IHE ACTR2_Mmus ----PKPPYYNI-LL---YSLVPLMLIAG---IV-IC-AFWVY-RHHKMAYPPV------ daf-4_Cele ----DKFPFYWI-II---IALSVILCIAL---LI-LAYVGWKF-QQNKKEEIKKQQKIK- BMPR2_Hsap -----SFNRDET-II---IALASVSVLAV---LI--VALCFGY-RMLTGDRKQG---L-- put_Dmel ----DGSNLIYIYIG---TSVFSVLM--V---IV-GM-GLLLY-RRRKQAHFN------- wit_Dmel ----QHQSFLAS-TM---LGLAGGLTALT---IG--IFLAVQY---CRTAKEKPE--P-- TGFBR2_Mmus -------VIIQV-TG---VSLLPPLGIAI---AV-I-IIFYCY-RVHRQQKLS------- ACTR2B_Hsap ----TAPTLLTV-LA---YSLLPIGGLSL---IV-LL-AFWMY-RHRKPPYGHVD--I-- ACTR2_Hsap ----PKPPYYNI-LL---YSLVPLMLIAG---IV-IC-AFWVY-RHHKMAYPPV------ TGFbRII_Spur KGQMLDREILVI-VV---CSVVPAVLLTI---VI-A-VAGYIHFTRYRQPMNDEL--N-- ACTR2_Spur ----KNEMLTKT-IL---YSIVPIVAIAL---VI-IM-LYWMC-RRHRYH-SLI------ BMPR2_Spur ----MNHEMERT-IL---IAVIPIFCVSV---AI--AIMYFIF-RMRLRSTKAQ---M-- AqueK683_Aque ----G-HT-VTV-GFWSA--IGSLSMIIIGIVCALWITIAFKW-KTTRSKYRKA------ AqueK684_Aque ----SNRVVYPSV-F---AALLLIMVLIL---CS--I-SIILC-RVRVAFRKRLD--M-- AqueK685_Aque ----TSTAAVTI-GLASGISILALMIALIAVVMM--LILAYSW-RKHS-PKFHRC--S-- AqueK686_Aque ----STDTMVTI-ILSSVIAFLAITLAIIGLLIA-CTLVCYC--RKYS-SNSRRH--S-- . TGFbR2_Hsap -------------------------------STWETGKTR-KLMEFSEHCAIILEDDRSD MISR2_Hsap ----------------------------VPEPRPDSGR---------------------- MISR2_Mmus ----------------------------DPEP--GSGG---------------------- BMPR2_Mmus ----------------------------HSMNMME--A---------------------- ACTR2B_Mmus VRQCQRWAGRRDGCADSF----------KPLPFQDPGP---------------------- ACTR2_Mmus -----------------------------LVPTQDPGP---------------------- daf-4_Cele -----------------FDMEKTDALEAGNVPLVEPEE---------------------- BMPR2_Hsap ----------------------------HSMNMME--A---------------------- put_Dmel -----------------------------EIPTHEAEI---------------------- wit_Dmel ----------------------------EESPLAPSGP---------------------- TGFBR2_Mmus -------------------------------PSWESSKPR-KLMDFSDNCAIILEDDRSD ACTR2B_Hsap --------------------------------HEDPGP---------------------- ACTR2_Hsap -----------------------------LVPTQDPGP---------------------- TGFbRII_Spur -------------------------------TQTQTSNTESTSIDMTTD-----ESETKR ACTR2_Spur -----------------------------AIPTTE------------------------- BMPR2_Spur ----------------------------SQLPMIE--A---------------------- AqueK683_Aque ------------------------------IDY--------------------------- AqueK684_Aque --------------------------------S-NYQL---------------------- AqueK685_Aque ----------------------------HQIQFSSETS---------------------- AqueK686_Aque ----------------------------HQIQFPA--A---------------------- TGFbR2_Hsap ISSTCA--NNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YE MISR2_Hsap -----DWS---VELQELPELCFSQVIREGGHAVVWAGQLQ------GKLVAIKAFP--PR MISR2_Mmus -----DCS---EELPELAELRFSQVIQEGGHAVVWAGRLQ------GEMVAIKAFP--PR BMPR2_Mmus -----AAA---EPSLDLDNLKLLELIGRGRYGAVYKGSLD------ERPVAVKVFS--FA ACTR2B_Mmus -----PP---PSPLVGLKPLQLLEIKARGRFGCVWKAQLM------NDFVAVKIFP--LQ ACTR2_Mmus -----PP---PSPLLGLKPLQLLEVKARGRFGCVWKAQLL------NEYVAVKIFP--IQ daf-4_Cele -----EMI-EMVETPKELPITDFQLISKGRFGKVFKAQYTPDS-GEKRLVAVKKLN--EF BMPR2_Hsap -----AAS---EPSLDLDNLKLLELIGRGRYGAVYKGSLD------ERPVAVKVFS--FA put_Dmel -----TN---SSPLLSNRPIQLLEQKASGRFGDVWQAKLN------NQDVAVKIFR--MQ wit_Dmel -----GYS---SNLRNVDNMNLIGMLGSGKYGTVMKGLLH------DQEVAVKIYP--EE TGFBR2_Mmus ISSTCA--NNINHNTELLPIELDTLVGKGRFAEVYKAKLKQNTSEQFETVAVKIFP--YE ACTR2B_Hsap -----PP---PSPLVGLKPLQLLEIKARGRFGCVWKAQLM------NDFVAVKIFP--LQ ACTR2_Hsap -----PP---PSPLLGLKPLQLLEVKARGRFGCVWKAQLL------NEYVAVKIFP--IQ TGFbRII_Spur LGEYSPPDSPLHLNGNYLPITLDELIGKGRFGAVWRAHWKINNGTKERTVAVKVFL--EY ACTR2_Spur -----PT---PSPMNSLPPIQLLEIKARGRFGAVWKASCL------NDIVAVKVFP--IQ BMPR2_Spur -----PPP---EPTFDLDQLKMMELVGQGRYCNVYRAALS------ENEVAVKVFT--GS AqueK683_Aque -------------SLSLDNSN-STLIYSHQIVTVRKA-EN------NRIIAVYKST--VS AqueK684_Aque -----SS---PSPTLY-DSPEFMKIIGHGRFARVYHARMG------TRDVAIKIFNGTLQ AqueK685_Aque -----TII-ELDEEPGLPPFQLIQSIGNGRFGSVWKALYE------KETVAVRVFS--QR AqueK686_Aque -----PNI-ELDERSAPLPFQLLQPIGNGRFGSVWKALYN------NETVAVKALS--LH * . :*: TGFbR2_Hsap EYASWKTEKDIFSD--IN---LKHENILQFLTAEERKTE---LGKQYWLITAFHAKGNLQ MISR2_Hsap SVAQFQAERALYEL--PG---LQHDHIVRFITASRGGPG--RLLSGPLLVLELHPKGSLC MISR2_Mmus AVAQFRAERAVYQL--LG---LQHDHIVRFITAGQGGPG--PLPSGPLLVLELYPKGSLC BMPR2_Mmus NRQNFINEKNIYRV--PL---MEHDNIARFIVGDERLTA--DGRMEYLLVMEYYPNGSLC ACTR2B_Mmus DKQSWQSEREIFST--PG---MKHENLLQFIAAEKRGSN---LEVELWLITAFHDKGSLT ACTR2_Mmus DKQSWQNEYEVYSL--PG---MKHENILQFIGAEKRGTS---VDVDLWLITAFHEKGSLS daf-4_Cele QKASFLAEKRIFDE--LNEYPKWYKSIVEFVCAEKIG-------DEYWIVTEFHERLSLY BMPR2_Hsap NRQNFINEKNIYRV--PL---MEHDNIARFIVGDERVTA--DGRMEYLLVMEYYPNGSLC put_Dmel EKESWTTEHDIYKL--PR---MRHPNILEFLGVEKHMD-----KPEYWLISTYQHNGSLC wit_Dmel HHQYYVNERNIYAL--PL---MECPALLSYFGYDERCTM--DGRMEYQLVLSLAPLGCLQ TGFBR2_Mmus EYSSWKTEKDIFSD--IN---LKHENILQFLTAEERKTE---LGKQYWLITAFHAKGNLQ ACTR2B_Hsap DKQSWQSEREIFST--PG---MKHENLLQFIAAEKRGSN---LEVELWLITAFHDKGSLT ACTR2_Hsap DKQSWQNEYEVYSL--PG---MKHENILQFIGAEKRGTS---VDVDLWLITAFHEKGSLS TGFbRII_Spur DSASWNVEKELFTDHSVM---MRHEHIVQFISAEVRRVSVTSPTRQYWLITKYYKNGSLH ACTR2_Spur DRNSWANEREIYSL--PH---MHHENLLHFIATEKHGEG---LEVEYWLISEFHHHGSLC BMPR2_Spur SKQCYMNELDIMGL--PH---MEHSNLLQYVGSGDRMGE--DGWVEHLLVVDMISKGSLM AqueK683_Aque ALSQWKIERDIYLT--PE---LRHESILTLLRAKR-VK--D---IGYQLVLKGSITGSLY AqueK684_Aque AKGSWTQEKDIYAT--ER---LEHENILKFLYHDHRFHE---GQDTLWLIFDYHSNGSLY AqueK685_Aque HRTSWQNERDIHLL--NS---TPHENILKFISSESRGRG---PSSEYFIITEYLPLGSLH AqueK686_Aque HKLSWQNERDIHLL--DS---TPHENILKFISSESRGRG---SSSEYFIITEYLPLGSLH : * : : . :: * TGFbR2_Hsap EYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC-G---RPKMPIVHRDLKSSNILVKND MISR2_Hsap HYLTQYTSDWGSSLRMALSLAQGLAFLHEERWQN-G---QYKPGIAHRDLSSQNVLIRED MISR2_Mmus HYLTQYTSDWGSSLRMALSLAEGLAFLHEERWQD-G---QYKPGIAHRDLSSQNVLIRED BMPR2_Mmus KYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG-D---HYKPAISHRDLNSRNVLVKND ACTR2B_Mmus DYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR-G-EGHKPSIAHRDFKSKNVLLKSD ACTR2_Mmus DFLKANVVSWNELCHIAETMARGLAYLHEDIPGL--K-DGHKPAISHRDIKSKNVLLKNN daf-4_Cele ELLKNNVISITSANRIIMSMIDGLQFLHDDRPYFF---GHPKKPIIHRDIKSKNILVKSD BMPR2_Hsap KYLSLHTSDWVSSCRLAHSVTRGLAYLHTELPRG-D---HYKPAISHRDLNSRNVLVKND put_Dmel DYLKSHTISWPELCRIAESMANGLAHLHEEIPASK-T-DGLKPSIAHRDFKSKNVLLKSD wit_Dmel DWLIANTLTFSECCGMLRSITRGISHLHTELRLG-D---QHKPCVAHRDINTRNVLVQAD TGFBR2_Mmus EYLTRHVISWEDLRKLGSSLARGIAHLHSDHTPC-G---RPKMPIVHRDLKSSNILVKND ACTR2B_Hsap DYLKGNIITWNELCHVAETMSRGLSYLHEDVPWCR-G-EGHKPSIAHRDFKSKNVLLKSD ACTR2_Hsap DFLKANVVSWNELCHIAETMARGLAYLHEDIPGL--K-DGHKPAISHRDIKSKNVLLKNN TGFbRII_Spur DYLRQRSVNWIDLCKLCGSAARGLAHLHAETYGSHG---LHKVPVAHRDLKSTNILVKDD ACTR2_Spur DYLKANVISWKELCGIAFSMAKGLAYLHEDIPPTT-AIPFVKHSVAHRDFKSKNVLIKNN BMPR2_Spur SYLRENTYDWHTMCRLAQTTAAGLAHLHQVIDTQ-V---GLKPAVVHRDINSRNVLVNAE AqueK683_Aque QYLQSHSPDELEAAKITHSMSSGLAHLHYMESSQS-HSKYRVITIAHCNINSHNILMKED AqueK684_Aque DYLQLHRLTFDELFSLCLSGAAGLEHLHSVDNC---P-ETYKPAIAHRDLKSKNILVKKD AqueK685_Aque QFLRHNTLSWEQAWNIMYSITSGITHLHSSSYYS-NGLLADKFSIAHRDIKPSNILVKSP AqueK686_Aque QFLRHNTLSWEQAWNIMYSIASGITHLHSNSYYNSNGLLLEKYSIAHRDIKPSNILVKSV * : : *: .** : * ::.. *:*:. TGFbR2_Hsap -LTCCLCDFGLSLRLDPTLS-------VD-DLANSGQVGTARYMAPEVLESRMNLENV-E MISR2_Hsap -GSCAIGDLGLALVLPGLTQPPAWTPTQPQGPAAIMEAGTQRYMAPELLDKTLDLQDWGM MISR2_Mmus -RSCAIGDLGLALVLPGLAQPPALAPTQPRGPAAILEAGTQRYMAPELLDKTLDLQDWGT BMPR2_Mmus -GACVISDFGLSMRLTGNRLV---RPGEE-DNAAISEVGTIRYMAPEVLEGAVNLRDCES ACTR2B_Mmus -LTAVLADFGLAVRFEPGK---------P-PGDTHGQVGTRRYMAPEVLEGAINFQR--D ACTR2_Mmus -LTACIADFGLALKFEAGK---------S-AGDTHGQVGTRRYMAPEVLEGAINFQR--D daf-4_Cele -MTTCIADFGLARIYSYDI---------E-QSDLLGQVGTKRYMSPEMLEGATEFTP--T BMPR2_Hsap -GTCVISDFGLSMRLTGNRLV---RPGEE-DNAAISEVGTIRYMAPEVLEGAVNLRDCES put_Dmel -LTACIADFGLAMIFQPGK---------P-CGDTHGQVGTRRYMAPEVLEGAINFNR--D wit_Dmel -LSCCIADFGFALKVFGSKYEYKGEVAMA-ETKSINEVGTLRYMAPELLEGAVNLRDCET TGFBR2_Mmus -LTCCLCDFGLSLRLDPTLS-------VD-DLANSGQVGTARYMAPEVLESRMNLENV-E ACTR2B_Hsap -LTAVLADFGLAVRFEPGK---------P-PGDTHGQVGTRRYMAPEVLEGAINFQR--D ACTR2_Hsap -LTACIADFGLALKFEAGK---------S-AGDTHGQVGTRRYMAPEVLEGAINFQR--D TGFbRII_Spur -GSCAIADFGLAIRLDPQSS-------TD-HLANSGQVGTPRYMSPEALECKVNLQDI-E ACTR2_Spur -TTACIADFGLACVFEAGK---------N-PGDTHGQVGTRRYMAPEVLEGAIQFKR--D BMPR2_Spur -GNCVIGDFGFAMQVCGSSVV---GEGDG-DNSTITDVGTVRYMSPEVLDGAVNLRDCEC AqueK683_Aque -GTVFLSDFSRSVKFNGGI---------I-AVGRDSEVIILGICLPEVLQGFQSFTI--T AqueK684_Aque -MTCCISDFGLAIKFDGVDM--------I-LSEAKGQVGTSRYMAPEILEGAVRFNQ--E AqueK685_Aque SGQCVVADFGQAFVLDPAAD-------DR-KLAVSGQVGTYRYMSPEALDARVNLRDS-E AqueK686_Aque SGHCVVADLGLAFILDPAAD-------DR-KLAVSGQVGTYRYMSPEALDARVNLRDI-E : *:. : :. ** *: : TGFbR2_Hsap SFKQTDVYSMALVLWEMTSRCNAV----GEVKDYEPPFGSKVRE-HPCVESMKDNVLRDR MISR2_Hsap ALRRADIYSLALLLWEILSRCPDL-RPDSSPPPFQLAYEAELGN-TPTSDELWALAVQER MISR2_Mmus ALQRADVYSLALLLWEILSRCSDL-RPDHRPPPFQLAYEAELGS-NPSACELWALAVEER BMPR2_Mmus ALKQVDMYALGLIYWEVFMRCTDL-FPGESVPDYQMAFQTEVGN-HPTFEDMQVLVSREK ACTR2B_Mmus AFLRIDMYAMGLVLWELVSRCKAA---DGPVDEYMLPFEEEIGQ-HPSLEELQEVVVHKK ACTR2_Mmus AFLRIDMYAMGLVLWELASRCTAA---DGPVDEYMLPFEEEIGQ-HPSLEDMQEVVVHKK daf-4_Cele AFKAMDVYSMGLVMWEVISRTKLH--QTDEPPNYQMPFQ-VIGF-DPTIGLMRNYVVSKK BMPR2_Hsap ALKQVDMYALGLIYWEIFMRCTDL-FPGESVPEYQMAFQTEVGN-HPTFEDMQVLVSREK put_Dmel AFLRIDVYACGLVLWEMVSRCDFA----GPVGEFQLPFEAELGL-RPSLDEVQESVVMKK wit_Dmel SLKQMDVYALGLVLWEVATRCSDFYAPGQATPPYKAPYEQEVGS-HPSFDQMQALVVRHK TGFBR2_Mmus SFKQTDVYSMALVLWEMTSRCNAV----GEVKDYEPPFGSKVRE-HPCVESMKDSVLRDR ACTR2B_Hsap AFLRIDMYAMGLVLWELVSRCKAA---DGPVDEYMLPFEEEIGQ-HPSLEELQEVVVHKK ACTR2_Hsap AFLRIDMYAMGLVLWELASRCTAA---DGPVDEYMLPFEEEIGQ-HPSLEDMQEVVVHKK TGFbRII_Spur SFKQMDTYALALILWEITSRCTLL----KDINEYELPFSRSLGDRRASLEMMKTLVVLRR ACTR2_Spur AFLRIDMYAFGLVLWELVTRCTVQ---DGPVPEYRLPFEEELGQ-GTSLEDMQEWVVVKR BMPR2_Spur ALKQVDVYALGLVVWEIAMRCKDL-YPRDEMGNYQMPFEEQVGL-HPTFEDMQILVSRER AqueK683_Aque SLTNSDIYSLGLCIWEVLNCCQIT---G---NSYTPPFHEVSDS-DISMDIMRSMIVEQG AqueK684_Aque AFLKIDIYAFGLILWEMLSCCDLN--NITSNPSYYPPFDGWVSA-NPSIDEMKRIVVEEK AqueK685_Aque SFKQIDVYAMSLVLWEVCMRYQSN---DVPVPPYQSPFFDMVGE-KPTLDQMKEIVVINK AqueK686_Aque SFKQIDMYALSLVLWEVCMRYQSD---DVPVPPYQSPFFDMVGE-KPTLEQMKEIVVNAN :: * *: .* **: : .: : TGFbR2_Hsap GRPEIPSFWLNHQ-GIQMVCETLTECWDHDPEARLTAQCVAERFSELEHLDRL-SG--RS MISR2_Hsap RRPYIPSTWRCFATDPDGLRELLEDCWDADPEARLTAECVQQRLAALAHPQES-HP--FP MISR2_Mmus KRPNIPSTWSCSATDPRGLRELLEDCWDADPEARLTAECVQQRLAALAYPHGA-SS--FP BMPR2_Mmus QRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSV-SP ACTR2B_Mmus MRPTIKDHWLKHP-GLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVN-GT----- ACTR2_Mmus KRPVLRDYWQKHA-GMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTN-II----- daf-4_Cele ERPQWRDEIIKHE-YMSLLKKVTEEMWDPEACARITAGCAFARVWNHIMSSPD-SS---- BMPR2_Hsap QRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELMMIWERNKSV-SP put_Dmel LRPRLLNSWRAHP-GLNVFCDTMEECWDHDAEARLSSSCVMERFAQLNKYPST-Q----- wit_Dmel ARPLFPTGWGGGA-AAKVVRDTCEDCWDHDADARLTSLCAEERMQEMSTLRPRAQA--QP TGFBR2_Mmus GRPEIPSFWLNHQ-GIQIVCETLTECWDHDPEARLTAQCVAERFSELEHPERL-SG--RS ACTR2B_Hsap MRPTIKDHWLKHP-GLAQLCVTIEECWDHDAEARLSAGCVEERVSLIRRSVN-GT----- ACTR2_Hsap KRPVLRDYWQKHA-GMAMLCETIEECWDHDAEARLSAGCVGERITQMQRLTN-II----- TGFbRII_Spur ERPPITDEWLRNP-GLTIIKNTVVDCWDEDPEARLTASCVEARFQELILWHEG-EP--HA ACTR2_Spur KRPVISDHWLKHR-GLELLCETIEECWDQDAEARLSAGCVEERIAQFSHSHMNGHM---- BMPR2_Spur KRPQFPDAWKQNSQALRSLKETIEDCWDHDAEARLTALCVEERIIELMVLWDKHRMI-SP AqueK683_Aque IVPALPAVFDEIK-EFSSVRNTVSECFDLEPEARPNSHILKNLFSKLLHDLLEKKSS-SP AqueK684_Aque KRPPIPQKFQTNL-KYSFIADIIVECWDDDADGRPAASLISRRLSEFQTAGYTASP---- AqueK685_Aque QRPLLPEKWNNDK-NLKRIIKLIVEGWDEDPEARLTAANIKIQLESLVGMRPKPPPSSTS AqueK686_Aque KRPGFTGVWYSDK-NLKRIIKLIKEGWDEDPEARLTAANIKIQLESLIGMRPKLDSLSSP * . : :* :. .* : . TGFbR2_Hsap ------------------------------------------------------------ MISR2_Hsap ESCPRG------------------------------------------------------ MISR2_Mmus ES-PQG------------------------------------------------------ BMPR2_Mmus TVNPMSTAMQNER--NLSHNRRVPKIG--PYPDY-------------------SSSSYIE ACTR2B_Mmus ------------------------------------------------------------ ACTR2_Mmus ------------------------------------------------------------ daf-4_Cele ------------------------------------------------------------ BMPR2_Hsap TVNPMSTAMQNER--NLSHNRRVPKIG--PYPDY-------------------SSSSYIE put_Dmel ------------------------------------------------------------ wit_Dmel SS-PLLNTN------NL------------------------------------VASPTAE TGFBR2_Mmus ------------------------------------------------------------ ACTR2B_Hsap ------------------------------------------------------------ ACTR2_Hsap ------------------------------------------------------------ TGFbRII_Spur ------------------------------------------------------------ ACTR2_Spur ------------------------------------------------------------ BMPR2_Spur TINPTTQGNAIPTHTMNEYTTRPTDIISREYPGIARLADGTMIAVRSNGQPVLGAA---- AqueK683_Aque IV---------------------------------------------------------- AqueK684_Aque HLPPLSNKS--------------------------------------------------- AqueK685_Aque ----QPDGR------NN------------------------------------FLSPILE AqueK686_Aque LS-PPPEGE------GV------------------------------------FLSPVSE TGFbR2_Hsap ------CS---------------------------------------------------- MISR2_Hsap ------------------------------------------------------------ MISR2_Mmus ------------------------------------------------------------ BMPR2_Mmus DSIHHTDS-IVKNISSEHSMSS-------------TPLTIGE-KNRNSINYERQQA---Q ACTR2B_Mmus ------TS---------------------------------------------------- ACTR2_Mmus ------TT---------------------------------------------------- daf-4_Cele ------E--------GYHSGSS-------------M--K-NRGVD--------------- BMPR2_Hsap DSIHHTDS-IVKNISSEHSMSS-------------TPLTIGE-KNRNSINYERQQA---Q put_Dmel ------------------------------------------------------------ wit_Dmel QGINIIAT-TTTAAAVHHQMSSDTTGLIQPPPNQQIPLAALE-REKNHLSYPQQQLQPYQ TGFBR2_Mmus ------CS---------------------------------------------------- ACTR2B_Hsap ------TS---------------------------------------------------- ACTR2_Hsap ------TT---------------------------------------------------- TGFbRII_Spur ------QS---------------------------------------------------- ACTR2_Spur ------NG--------HHPVSP-------------TPLI--------------------- BMPR2_Spur SETSGTAS-DTKNHHGLHSSVS-------------SGLE----KN----------E---R AqueK683_Aque ------EEEE-------------------------------------------------- AqueK684_Aque ------SK-----ESGFHSLSG-------------QPLLSSSGVNNDALATDYNINT--- AqueK685_Aque ----SSES-SCK-------------------------------KYRLSS----------- AqueK686_Aque ----TSHS-SCK-------------------------------KVHISA----------- TGFbR2_Hsap ------------------------------------------------------------ MISR2_Hsap ----CP------------------------------------------------------ MISR2_Mmus ------------------------------------------------------------ BMPR2_Mmus ARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMP--YPD-ETHLHATNV---AQSI ACTR2B_Mmus ------------------------------------------------------------ ACTR2_Mmus ------------------------------------------------------------ daf-4_Cele -----------------------DVEQ-----------SEKPE----------------- BMPR2_Hsap ARIPSPETSVTSLSTNTTTTNTTGLTPSTGMTTISEMP--YPD-ETNLHTTNV---AQSI put_Dmel ------------------------------------------------------------ wit_Dmel GRNPCQERNLAPLT---------------------------------------------- TGFBR2_Mmus ------------------------------------------------------------ ACTR2B_Hsap ------------------------------------------------------------ ACTR2_Hsap ------------------------------------------------------------ TGFbRII_Spur ------------------------------------------------------------ ACTR2_Spur ------------------------------------------------------------ BMPR2_Spur LRLMSPGTISTSLSSQS-DLNLIDLTASAPPVDPKNLH--HSDDSIERYTTDLKYGPQQS AqueK683_Aque ------------------------------------------------------------ AqueK684_Aque -----------------------PLPP-----------TPTPS----------------- AqueK685_Aque -----------SFSESS-G-----------NAVIFSNPSS----K--LSGR--------- AqueK686_Aque -----------SFSGST-N------------AML--SPAAAPH-S--FHGR--------- TGFbR2_Hsap ------------------------------------------------------------ MISR2_Hsap --------------------PL----------C--------------------------- MISR2_Mmus --------------------------------C--------------------------- BMPR2_Mmus GPTPVCLQLTEEDLETNKLDPK----------EVDKNLKES--SDENLMEH--------- ACTR2B_Mmus ------------------------------------------------------------ ACTR2_Mmus ------------------------------------------------------------ daf-4_Cele ------------G--------------------IE----EMQH---------YH---A-- BMPR2_Hsap GPTPVCLQLTEEDLETNKLDPK----------EVDKNLKES--SDENLMEH--------- put_Dmel ------------------------------------------------------------ wit_Dmel ----------------MRTPPV----------LVERSKKHS--FQTQPQEN--------- TGFBR2_Mmus ------------------------------------------------------------ ACTR2B_Hsap ------------------------------------------------------------ ACTR2_Hsap ------------------------------------------------------------ TGFbRII_Spur ------------------------------------------------------------ ACTR2_Spur ---------------------------------M-------QT---------MH---N-- BMPR2_Spur GP-KYCDQYGFSEPSTSPSRPL----------VVNEMRAGL--SKDQMTDNLSHGMGKLK AqueK683_Aque ----------------------------------------------------LE---A-- AqueK684_Aque ------------SPS------------------I-------TLSPTEIKSHTVH---D-- AqueK685_Aque ---------------------FSVDH-TNNASSH-------------------------- AqueK686_Aque ---------------------FSLDHGGHNPVTV-------------------------- TGFbR2_Hsap --------E--------------------------------------------------- MISR2_Hsap ------------------------------------------------------------ MISR2_Mmus ------------------------------------------------------------ BMPR2_Mmus -------SLKQFSGPDPLSSTSSSLLYPLIKLAVEVTGQQ--DFTQ-------------A ACTR2B_Mmus --------D-C------L----VS------------------------------------ ACTR2_Mmus --------E-D------I----VT------------------------------------ daf-4_Cele ----SSPSKRQHPSPNPFFDSCPP--PPPIPVILENGGILQPD----------------- BMPR2_Hsap -------SLKQFSGPDPLSSTSSSLLYPLIKLAVEATGQQ--DFTQ-------------T put_Dmel ---------------------L-------------------------------------- wit_Dmel -------SLSCLEHDVSVE-----EL-----IASHQHQQQ------------KNTIVSTG TGFBR2_Mmus --------Q--------------------------------------------------- ACTR2B_Hsap --------D-C------L----VS------------------------------------ ACTR2_Hsap --------E-D------I----VT------------------------------------ TGFbRII_Spur --------F--------------------------------------------------- ACTR2_Spur ----STSFE-N------TGNTEST------------------------------------ BMPR2_Spur NKSSSMPSWNHINGVDPRSRGANQP-VNMAKLDTNLHRQQ--ARSASPKQSNQNGYEASG AqueK683_Aque ----FTGTE-Q------T------------------------------------------ AqueK684_Aque ----FSSSS-T------SSSSCPT--RS-------------------------------- AqueK685_Aque -----------------------RTIL--N------------------------------ AqueK686_Aque -----------------------SMILSLS------------------------------ TGFbR2_Hsap ------------------------------------------------------------ MISR2_Hsap --PEDC------------------------------------------------------ MISR2_Mmus --PENC------------------------------------------------------ BMPR2_Mmus ANGQACLIPDVPPAQIYPLPKQQNLPKRPTSLPLNTKN-STKEPRLKFGNKHKSNL-KQV ACTR2B_Mmus ------------------------------------------------------------ ACTR2_Mmus ------------------------------------------------------------ daf-4_Cele --------------N--AEPEPEELPDLPIVEKI----YDIATNML-------------- BMPR2_Hsap ANGQACLIPDVLPTQIYPLPKQQNLPKRPTSLPLNTKN-STKEPRLKFGSKHKSNL-KQV put_Dmel ------------------------------------------------------------ wit_Dmel GNGNSCLGQ--------GFPKQQNTDQKLRGW--HGVR-ALIHKK-LFRKEHAEELCRQL TGFBR2_Mmus ------------------------------------------------------------ ACTR2B_Hsap ------------------------------------------------------------ ACTR2_Hsap ------------------------------------------------------------ TGFbRII_Spur ------------------------------------------------------------ ACTR2_Spur ------------------------------------------------------------ BMPR2_Spur SSGASSEG--------AGPSSIPNMNIRPNSLPLQSTHRGSKKKLMAVYNPNTGPT-TKV AqueK683_Aque ----------------------EELPSSE------------------------------- AqueK684_Aque -----------------------SLPIHFSPAKK----SDTSDPRS-------------- AqueK685_Aque ----D--------------------LRRYR------------------------------ AqueK686_Aque ----DV-----------------QVQYRPP------------------------------ TGFbR2_Hsap ------------------------------------------------------------ MISR2_Hsap ---------TSI-------------------------PAPTILPC-RPQ---R------- MISR2_Mmus ---------LSA-------------------------PASAVFPC-RPQ---Q------- BMPR2_Mmus ETGVAKMN-TIN--------AAEPHVVTVT------------------------------ ACTR2B_Mmus ------------------------------------------------------------ ACTR2_Mmus ------------------------------------------------------------ daf-4_Cele --------------------------------------------F-SR------------ BMPR2_Hsap ETGVAKMN-TIN--------AAEPHVVTVT------------------------------ put_Dmel ------------------------------------------------------------ wit_Dmel QLGEEKSN-LVT--------AL---------------RRPNNLDL-NPR---LD------ TGFBR2_Mmus ------------------------------------------------------------ ACTR2B_Hsap ------------------------------------------------------------ ACTR2_Hsap ------------------------------------------------------------ TGFbRII_Spur ------------------------------------------------------------ ACTR2_Spur ------------------------------------------------------------ BMPR2_Spur QTGIAKMD-SVAPSCHQVKMAANTHKQQPTHNAVEKLRNGNVGNL-EPE---ADRPHSWA AqueK683_Aque ----------------------------------------VVLP---------------- AqueK684_Aque --------------------------------------------R-K------------- AqueK685_Aque -DGIGLSNNIST-------------------------TTTDS---T----QPN------- AqueK686_Aque -DTVATANSESI-------------------------TVPALIPQSEPTTAPQ------- TGFbR2_Hsap ------------------------------------------------------------ MISR2_Hsap ------------------------------------------------------------ MISR2_Mmus ------------------------------------------------------------ BMPR2_Mmus --MNGVAGRSHNVNSHAATTQYANGAVPAGQAANIVAHRSQEMLQNQFIGEDTRLNINSS ACTR2B_Mmus ------------------------------------------------------------ ACTR2_Mmus ------------------------------------------------------------ daf-4_Cele ---------------------------------------E---------------ELDLM BMPR2_Hsap --MNGVAGRNHSVNSHAATTQYANGTVLSGQTTNIVTHRAQEMLQNQFIGEDTRLNINSS put_Dmel ------------------------------------------------------------ wit_Dmel ------------------------------------------------------------ TGFBR2_Mmus ------------------------------------------------------------ ACTR2B_Hsap ------------------------------------------------------------ ACTR2_Hsap ------------------------------------------------------------ TGFbRII_Spur ------------------------------------------------------------ ACTR2_Spur ------------------------------------------------------------ BMPR2_Spur CDSSSGSDRSH-------EIDRKNGNACSGSASCIAKGDNGKRKVTPFRLLTEKLSIHKG AqueK683_Aque ------------------------------------------------------------ AqueK684_Aque ------------------------------------------------------------ AqueK685_Aque ------------------------GAYTGG------------------------------ AqueK686_Aque ------------------------L----------------------------------- TGFbR2_Hsap ------------------------------------------------------------ MISR2_Hsap ------------------------------------------------------------ MISR2_Mmus ------------------------------------------------------------ BMPR2_Mmus PDEHEP--LLRREQQAGHDEGVLDRLVDRRERPLEG-GRTNSNNNNSNPCSEQDILTQGV ACTR2B_Mmus ------------------------------------------------------------ ACTR2_Mmus ------------------------------------------------------------ daf-4_Cele NA----------QRQ-------VEYE-------------------------------AGA BMPR2_Hsap PDEHEP--LLRREQQAGHDEGVLDRLVDRRERPLEG-GRTNSNNNNSNPCSEQDVLAQGV put_Dmel ------------------------------------------------------------ wit_Dmel --KPPPDQLRSAEQRMGTPAHIVPRSLSSSLIKHIN-GTTNNNSIQS-HGSELQTLTRPA TGFBR2_Mmus ------------------------------------------------------------ ACTR2B_Hsap ------------------------------------------------------------ ACTR2_Hsap ------------------------------------------------------------ TGFbRII_Spur ------------------------------------------------------------ ACTR2_Spur ------------------------------------------------------------ BMPR2_Spur KDKKEP--KDQTDCNGVNNRNPVELNVNNNARAIAPQTLANGSDNDSVACSDLSNGHAGV AqueK683_Aque ------------------------------------------------------------ AqueK684_Aque ------------------------------------------------------------ AqueK685_Aque ----------------------------------------GSRDEVSSSESQDEV----- AqueK686_Aque ----------------------------------------ASNNEVSNGGSQDEV----- TGFbR2_Hsap ------------------------------------------------------------ MISR2_Hsap ----------SACHFSVQQGPCS------------------------------------- MISR2_Mmus ----------SSCLLSVQQGPGS------------------------------------- BMPR2_Mmus T------------STAADPGPSKPRRAQRPNSLDLSATNILDGSSIQIGESTQDGKSGSG ACTR2B_Mmus -----------LVT--S----V-------------------------------------- ACTR2_Mmus -----------VVT--M----V-------------------------------------- daf-4_Cele -----------DTR--A----S-------------------------------------- BMPR2_Hsap P------------STAADPGPSKPRRAQRPNSLDLSATNVLDGSSIQIGESTQDGKSGSG put_Dmel -----------LIK--N----H-------------------------------------- wit_Dmel SKRRPGHLRTNSLMATTGQGPPTEQQMRRQHSLEVFR-------------EVFSG-RGSS TGFBR2_Mmus ------------------------------------------------------------ ACTR2B_Hsap -----------LVT--S----V-------------------------------------- ACTR2_Hsap -----------VVT--M----V-------------------------------------- TGFbRII_Spur ------------------------------------------------------------ ACTR2_Spur -----------DIA--L----Y-------------------------------------- BMPR2_Spur -------------SLNGDAYPLN------------------------------------- AqueK683_Aque -----------LT---Q--HSQT------------------------------------- AqueK684_Aque -----------AVT--P----L---RSNPGKPTDLGSGNISGGDLFS--QYDLSSSSGAG AqueK685_Aque ----------NVVD--V------------------------------------------- AqueK686_Aque ----------NVID--ATTGQPK------------------------------------- TGFbR2_Hsap ------------------------------------------------------------ MISR2_Hsap -RNPQ-----------P------------------------------------------- MISR2_Mmus -RSPD-----------P------------------------------------------- BMPR2_Mmus EKIK---RRVKTP----YSLKRWRPSTWVISTEPLDCEVNNNGSDRAVHSKSSTAVYLAE ACTR2B_Mmus ------------------------------------------------------------ ACTR2_Mmus ------------------------------------------------------------ daf-4_Cele ------------------------------------------------------------ BMPR2_Hsap EKIK---KRVKTP----YSLKRWRPSTWVISTESLDCEVNNNGSNRAVHSKSSTAVYLAE put_Dmel ------------------------------------------------------------ wit_Dmel ERLRDPSERVKTPGDVPPSVRKARASK-------------------------TLSLY--D TGFBR2_Mmus ------------------------------------------------------------ ACTR2B_Hsap ------------------------------------------------------------ ACTR2_Hsap ------------------------------------------------------------ TGFbRII_Spur ------------------------------------------------------------ ACTR2_Spur ------------------------------------------------------------ BMPR2_Spur ------------------------------------SKL--------------------- AqueK683_Aque -GTMS-----------P------------------------------------------- AqueK684_Aque D--------VVSP----LCDDVRKFSLQLDYTE---------------------DF---- AqueK685_Aque ------------------------------------------------------------ AqueK686_Aque -RLSD------------------------------------------------------- TGFbR2_Hsap ----EKIPED-GSLNTTK MISR2_Hsap -----------ACTLSPV MISR2_Mmus ------VGD-TVQVYVNE BMPR2_Mmus GGTATTTVS-KDIGMNCL ACTR2B_Mmus -----TNVDL-LPKESSI ACTR2_Mmus -----TNVDF-PPKESSL daf-4_Cele ----TPTPS-GTFGTFTT BMPR2_Hsap GGTATTMVS-KDIGMNCL put_Dmel -----TNIDDAKESTNCL wit_Dmel -----DRMM-DSSLLNIL TGFBR2_Mmus ----EKIPED-GSLNTTK ACTR2B_Hsap -----TNVDL-PPKESSI ACTR2_Hsap -----TNVDF-PPKESSL TGFbRII_Spur ----YTSKGK-RGRTTLV ACTR2_Spur ----RNSPSP-PPKESNL BMPR2_Spur -VNGSAKLQ-ANFELECV AqueK683_Aque -------GHV-IIAETHL AqueK684_Aque ----KPDNE-ENPTETTL AqueK685_Aque ----------TTGQPKSH AqueK686_Aque ------AEH-DDTTTSLS