CLUSTAL W (1.83) multiple sequence alignment Shk1_Ddis MATQQQQQ-----------------QQQQQQQQ--------------------------- Shk2_Ddis MNDKISKL---------ESSILQLTEEVKQLESKQASKELEIRTLVDNAINSQNPAQERE Shk3_Ddis MDSGLGS----------------------------------------------------- Shk4_Ddis MKRFFSNL---------FKRKQDQNSHIKQINGPTTSTPTTTPTTPTTPTTTQTPTPQNN Shk5_Ddis MDINLIKQYINSSLPNDKESLIQYYGQLKQILNALSDKEQQQ-LLNNNGKISE--QQQLS * . Shk1_Ddis ------------------------IK----A--R---------KDI-------------- Shk2_Ddis -----LINKLFTESLIDLKLKAEKIQTLERYRQEIITNLLVE------------------ Shk3_Ddis ------------------------------------------------------------ Shk4_Ddis NTNNNTNNNNNTNSNNSNQQKKEQAQ----A--SPSTNQTQTPSNNTISTSPTVTTQPSF Shk5_Ddis IEN-------NYKVIGS-I--EEKMK----SIEHLFNNLDVS------------------ Shk1_Ddis ------------------------------------------------------------ Shk2_Ddis ------------------------------------------------------------ Shk3_Ddis ------------------------------------------------------------ Shk4_Ddis TPGVISTSKLTTSPPESPRPPTSTTNTTQPSTTTTTATNSTNTNTASAPTKTASPSSPSA Shk5_Ddis ------------------------------------------------------------ Shk1_Ddis ------------------------------------------------------------ Shk2_Ddis ---Q-KQPNDTSI-----------------------------ISAWEQLKISSFRINPNN Shk3_Ddis ------------------------------------------------------------ Shk4_Ddis TASPNNNSNNTTTTAATTTTTTTTTTTTNANQTASVNHTSSDQSLNAQN-VTQTNNNNNN Shk5_Ddis ---DSNNNNST-----------------------SP----VFISLDNQNTVNNNNNNNNN Shk1_Ddis ------------------------------------------------------------ Shk2_Ddis NNNNSNNTNSSDSNQNYSS--VILNGSLTEDSTSTISPDSTKN----------------- Shk3_Ddis ------------------------------------------------------------ Shk4_Ddis NNNNNNNNNANNTKPINPNDYIPLDFV---DST----P---------------------- Shk5_Ddis NNNNNNNNNNNNNNSLAPT--VILDNNDNKKTAEIILPDHHNNTPQQQPEQQVQQQQVQQ Shk1_Ddis ----QIQQA-----------------------------------QSASDILGPPEISETE Shk2_Ddis --------------------------------------------RDEE-EIIRWEIDRNE Shk3_Ddis --------S-----------------------------------YPE-ERSGPPEIRPEE Shk4_Ddis ----KVDNN-----------------------------------QPKRKASGPPEILPEE Shk5_Ddis QQQVQQQQQQPEQQQQHLTEEQIQKQQQSQASIQQAIANMGEKKRSSSRHSGPPEIPPEE ** * Shk1_Ddis ITT---ESILGDGSFGTVYKGRCRLKDVAVKVMLKQV-DQKTLTDFRKEVAIMSKIFHPN Shk2_Ddis ISYN-REAKLGSGAFGSVYKGIVRGKEVAIKKLTQTVFEENTMNEFKKEVSLMAKLRNPH Shk3_Ddis INF---EELIGTGSFGKVYKGRCRQKAVAVKLLHKQNFDAATLSAFRKEVHLMSKIYHPN Shk4_Ddis IDR---TDFLGQGSFGSVYKGKCRGQEVAVKIPRKQKLSLYELTSFRHEVKIMSKIFHPN Shk5_Ddis IKFDVKTDLLGGGAYGKVYKATCRGKKVAVKVPKKQTLSESELKSFKNEVEIMKQIFHPN * :* *::*.***. * : **:* : . :. *::** :* :: :*: Shk1_Ddis IVLFLGACTSTPGKLMICTELM-KGNLESLLLDPMVK--LPLITR-MRMAKDAALGVLWL Shk2_Ddis LLLFMGACTA-PEDLSIVTELMPKGSVHSLLRAKEDTSDFITFKRAILIARDTVLGMTWL Shk3_Ddis ICLFMGACTI-PGRCVIVTELVPKGNLETLLHDQKIQ--LPLYLR-MRMARDAALGINWL Shk4_Ddis VVLFLGACTQ-SGKMQIVTELC-QTDLEKLLHNDRTKKEFSLFRR-MQMAKDAALGMNWL Shk5_Ddis VVLCLGACTK-PGKVMIVSELM-QTDLEKLIHSSEVEP-PPLYER-MKMCLDAALGINWL : * :**** . * :** : .:..*: * : :. *:.**: ** Shk1_Ddis HSSNPVFIHRDLKTSNLLVDANLTVKVCDFGLSQIKQRGENLKDGQDGAKGTPLWMAPEV Shk2_Ddis HASN--ILHLDLKPANLLVDQNWVVKVADFGLSKYMKPDS--KDKLLGQAGSPLYMAPEM Shk3_Ddis HESNPVFVHRDIKSSNLLVDENMRVKICDFGLSALKQKHKMLKD-QSSAKGTPLYMAPEV Shk4_Ddis HGITR-IVHNDLKTANLLVDINLRVKVTDFGFSQIKE-GEEFQD--KAAKGTPLWMAPEV Shk5_Ddis HGICN-IIHRDLKLANLMISKDKTVKIGDFGFSQVIKTGTTLSD-QKGPKGTALYMAPEV * ::* *:* :**::. : **: ***:* : .* . *:.*:****: Shk1_Ddis LQGRLFNEKADVYSFGLVLWQIFTRQELFPE-FDNFFKFVAAICEKQLRPSIPDDCPKSL Shk2_Ddis LVNQPYDGKVDVFSFSILLWELLTKQEPYNKLYSSYPQLVEGVVNKKNRPIIPDYFPTRL Shk3_Ddis MMFKEFNESSDVYSFGIVLWEILTRKEPFSH-HRELEKFREAVCVKHERPPIPNDCLDSL Shk4_Ddis MMGNPYNEKADVYSFGIILWEILTKEAPYSH-HKDYDIFFNAICNEKERPPIPADTLPSL Shk5_Ddis MMKHEFNEKADVYSFGLILYEMATCEELFPE-YSEIDPFYDAICNKKLRPPIPDSFPKSL : . :: . **:**.::*::: * : : . . . : .: :: ** ** * Shk1_Ddis KELIQKCWDPNPEVRPSFEGIVSE--LEEIIIDCCIPDEYGAILWKNHFKH-----ENEA Shk2_Ddis KDLLARCWDHYPSRRPSFAEISKQRILETILIDGLILDSSARQFWSQYYMG-----KEEV Shk3_Ddis RRLIEKCWDKEPISRPSFKEIISA--LDHVIIDAAISDLNGRDFWKKSFLT-----EQEV Shk4_Ddis RHLIQTCWDHNPQNRPSFSEILFR--LNEILIDCAIDFDDGRKYWKEHFLVPKQELQEEV Shk5_Ddis KTLIQKCWDHDPNKRPSFNEVTQR--MNEVLTDTAISGLDAAMFWKYNFIKPE---SESV : *: *** * **** : :: :: * * . *. : .:.. Shk1_Ddis NWKDFINVFSNFVGLTNANTPSMSDLLQFSPNLNGSTIELNFKCLKSIIVSSPK--GPHE Shk2_Ddis PWNSFIVNFSLYCGFESNLS----------------ADDIKIKFLKLLLV-------PVD Shk3_Ddis PWEAFIDALCNWSKAPARNQCD---------KT--SIDYLNIKCLKAVLAESPKSEGTGV Shk4_Ddis EWSDFEKTLKATHKQLN----------------------LDYAPLKELLVQQSHQTVQKT Shk5_Ddis PWNEFVYKLSSVVNLPTQV----------------------LSPLAQLFVSQSYE--EEI *. * : * ::. Shk1_Ddis EEVVLMEQFGKVLAWFGNLKE--DGSQILDKIRQLMECAWFHGDISTSESENRLRQKPEG Shk2_Ddis SDMVTIDNFGKILTWVGPLT---NGREFFDKVYSICSIKGFMAATSSKNASQYLAGKKTG Shk3_Ddis ETVVNIEKFGKILEFFGPVPEPAPGHSIMDTVREILSQKWFHGDLDTTEAASRLNGQPIG Shk4_Ddis KQVVTMERFDKVSKWFGSFFEPNTGIETIDNINKLSAKIWFHGDIVREQATSRLSKAAEG Shk5_Ddis GGVVTMERFDLMNKWFGNFFNSKYGPAILYEMIELLKKRWFHFDISRDISEKRLRGRPEN :* ::.*. : :.* . * : : .: * : . * . Shk1_Ddis TFLVRFSTSEYG--AYTISKVSKNGGISHQRIHR---P------------QGK----FQV Shk2_Ddis TYILRFSS-DPG--SYAISYLNKNKEIIHARVIY---KQGS---------GYI----HHG Shk3_Ddis SFLIRFSSTNAG--CFTISQVVDGGSIKHQRVSR---Q------------GVK----FNY Shk4_Ddis AFLIRLSSTEPK--TCPFTLSMKNN--QHRRIQLIDENNF---------TGFK----IQG Shk5_Ddis TFLLRLSANDPIKTPFTISK-TKGSKPTHKRVSR---EDVQINEIKQFPMGYKFTVPLDG ::::*:*: : .:: .. * *: . Shk1_Ddis NNSKYLSVKELITGEAQA--------LGINTPCLGSRFLSLIYK--------------AQ Shk2_Ddis GQTHYATLDDLIKNTFKS--------LGIKEPFEGGPFHALTVAASSSKPFNIAGAYIPV Shk3_Ddis QNVIYNSLIEIVSKNGGGANGDVKLDSQLGVPNY--KFMSLFCV------------L-NK Shk4_Ddis KTAVYNSLIELVEKCND---------YPLLVPCP--KFTQET--------------F-NP Shk5_Ddis NELVFGSITQMVEELHRI--------GNLSIPCP-------ITE--------------IK : :: ::: : * Shk1_Ddis LSGYIN Shk2_Ddis APSKKI Shk3_Ddis ESEVYQ Shk4_Ddis YDPYTN Shk5_Ddis VPYLTD