CLUSTAL W (1.83) multiple sequence alignment TESK2_Hsap MDRSKRNSIA-----GF------------------------------------------- TESK1_Hsap MAGER-PPLR-----GP------------------------------------------- cdi_Dmel MSLNQHS--------GP------------------------------------------- TESK1_Mmus MAGER-PPLR-----GP------------------------------------------- TESK2_Mmus MDRSKRNSIA-----GF------------------------------------------- Tesk_Spur MNIDEK------------------------------------------------------ AqueK482_Aque MVDSKFS--------A-------------------------------------------- AqueK483_Aque MNFLRRVGRS---SRSPSPLTRGSGNNSPTDDWSNTRSNTGNRSSSSSSGTANRKKEGKE AqueK484_Aque MTDGVDDTLQLTEAGGLVP----------------------------------------- * TESK2_Hsap ----------------------------------------PPR-VERL------------ TESK1_Hsap ---------------------------------------GPGP-GEVP------------ cdi_Dmel ---------------------------------------GPPSEICGLSVDQVDSSAASP TESK1_Mmus ---------------------------------------GP---GEAP------------ TESK2_Mmus ----------------------------------------PPR-VERL------------ Tesk_Spur ------------------------------------------------------------ AqueK482_Aque ---------------------------------------LPA-QLSSDSD---------- AqueK483_Aque ERKEHSTSGSNMIDGVDDNLQLTEAGCLVPDTPLSPSSPVPPLSIKPHPL---SSS-VSP AqueK484_Aque ------------------------------DMSLS-PSPVPPISIEPHSL---SSS-VSP TESK2_Hsap ------------------------------------------EEFEGG-----------G TESK1_Hsap ------------------------------------------GEGPPG-----------P cdi_Dmel F-------------------IWPSTAGMCTTATTVTTSTNGDATAEAPVKHQ-------P TESK1_Mmus ------------------------------------------GEG--------------P TESK2_Mmus ------------------------------------------EEFEGG-----------G Tesk_Spur ------------------------------------------------------------ AqueK482_Aque ------------------------------------------DSDYSP-----------P AqueK483_Aque PNSPGSPTVTISASEKLCKKPHPRSLDM--RKLSIPTSVS-----------LDCIKHN-G AqueK484_Aque PDSPGPPTVTISASEKLCKKPHPQSLGM--KKLSIPTSASLDCINEYEREKEEEYDSFRV TESK2_Hsap GGEGNVSQVG---------------R-VWPSSYRALISAFSRLTRLDDFTC-EKIGSGFF TESK1_Hsap GGTG--GGPG---------------R-GRPSSYRALRSAVSSLARVDDFHCAEKIGAGFF cdi_Dmel LHNG--GWIGNGLPPAPVTRTISSDRLVTGSSCRALRTAVSALYSVDDFVK-EKIGSGFF TESK1_Mmus GGAG--GGPG---------------R-GRPSSYRALRSAVSSLARVDDFDCAEKIGAGFF TESK2_Mmus GGDGNTVQVG---------------R-VSSSSYRAIISAFSRLTSLDDFTR-EKIGSGFF Tesk_Spur ------------------------------------------------------LTAKQR AqueK482_Aque NSRK--GGTP---------------R-PKSSSFIALKDAVYQLTCLNDFTR-EKIGQGFF AqueK483_Aque DYDSPAHHVP---------------R-PSSPLLSALREAVESVSNMEDFERIEKIGSGFF AqueK484_Aque DSDSPSHHVP---------------R-PS-SALRALREAVGSVSNMEDFERIEKIGSGFF : TESK2_Hsap S-EVFKVRHRASGQVMALKMNTLS---SNRANMLKEVQLMNRLSHPNILRFMGVCVHQGQ TESK1_Hsap S-EVYKVRHRQSGQVMVLKMNKLP---SNRGNTLREVQLMNRLRHPNILRFMGVCVHQGQ cdi_Dmel S-EVYKVTHRTTGQVMVLKMNQLR---ANRPNMLREVQLLNKLSHANILSFMGVCVQEGQ TESK1_Mmus S-EVYKVRHRQSGQVMVLKMNKLP---SNRSNTLREVQLMNRLRHPNILRFMGVCVHQGQ TESK2_Mmus S-EVFKVRHRASGQVMALKMNTLS---SNRANLLKEMQLMNRLSHPNILRFMGVCVHQGQ Tesk_Spur EESKTKIRHKADGRVMVAKIGKQKIWRANQHKMIQELELLNKLQHPNVVRYMGACVKDGH AqueK482_Aque A-EVFKVTHKNTGEVMVLKLNKSR---NNSKQMLAEIQLLNRLSHSNILGFKGSCVHEGS AqueK483_Aque A-EVYKVRHKLTDEIMVLKVNKGL---TG-TKTRQEVELLKRLHHPNILHYIGSCIHNGQ AqueK484_Aque A-DVYKVRRKLTNQIMVLKVNKGL---TA-TKTRQEVELLKRLNHPNILHYIGSCIHNEQ . *: :: ..:*. *:. : *::*:::* *.*:: : * *::: TESK2_Hsap LHALTEYINSGNLEQLLDSNL--HLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCL TESK1_Hsap LHALTEYMNGGTLEQLLSSPE--PLSWPVRLHLALDIARGLRYLHSKGVFHRDLTSKNCL cdi_Dmel LHALTEYINGGSLEQLLANKE-VVLSATQKIRLALGIARGMSYVHDAGIFHRDLTSKNVL TESK1_Mmus LHALTEYMNGGTLEQLLSSPE--PLSWPVRLHLALDIAQGLRYLHAKGVFHRDLTSKNCL TESK2_Mmus LHALTEYINSGNLEQLLDSDL--YLPWTVRVKLAYDIAVGLSYLHFKGIFHRDLTSKNCL Tesk_Spur IHPVLEYVSGGCLTDILADES-LALSWRQKGDLATDIARGMTYLHSQNVCHRDLTSANCL AqueK482_Aque LHALTEYINGGTLEELLSSDP--HLSWSKRIKIAHDIANGMAYLHNRGVFHRDLTSKNCL AqueK483_Aque LHPLTEFVNGGTLKSLIQDVEKNPFPPEQRIQLSLDMAMGMEYLHNNGMLHRDFNSHNCL AqueK484_Aque LHPLTEFVNGGTLKSLIQDVEKNPFPREQRIQLSLDMALGMEYLHENGMLHRDFNSNNCL :*.: *::..* * .:: . :. : :: .:* *: *:* .: ***:.* * * TESK2_Hsap IKRDEN-GYSAVVADFGLAEK----------------------------------IPDVS TESK1_Hsap VRREDR-GFTAVVGDFGLAEK----------------------------------IPVYR cdi_Dmel IRNLANDQYEAVVGDFGLAAK----------------------------------IPVKS TESK1_Mmus VRREDR-GFTAVVGDFGLAEK----------------------------------IPVYR TESK2_Mmus IKRDEN-GYSAVVADFGLAEK----------------------------------IPDAS Tesk_Spur VRQKPNNVLEAILTDFGLARVLGCMPDPPPNSPRTPESPEPDIIDAPNGGPMLPRIPSAC AqueK482_Aque IQKSDDGSLNCVVADFGLAAK----------------------------------IV--- AqueK483_Aque LRKEGD-RYTAVVADFGLATK----------------------------------NPNLI AqueK484_Aque LRKEGD-RYTAVVADFGLAAK----------------------------------NPNLM ::. .:: ***** TESK2_Hsap MGS--EKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENF TESK1_Hsap EGARKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDF cdi_Dmel R-K--SRLETVGSPYWVSPECLKGQWYDQTSDVFSFGIIQCEIIARIEADPDMMPRTASF TESK1_Mmus EGTRKEPLAVVGSPYWMAPEVLRGELYDEKADVFAFGIVLCELIARVPADPDYLPRTEDF TESK2_Mmus IGR--EKLAVVGSPFWMAPEVLRDEPYNEKADVFSYGIILCEIIARIQADPDYLPRTENF Tesk_Spur MDVP-RKMSVVGTAFWMAPEVLRGEEYTRQVDVFSFGIVVCEIVARITANPDDLPRTGKF AqueK482_Aque ------------------------------------------------------------ AqueK483_Aque KKLR-RNQSMVGTPYWMAPEVLHGKEYNEKADTYSYGIVLCEIVSRKDADPDEIPRK--- AqueK484_Aque KDLR-CNQSVVGTPFWMAPEVLHGKRYDKKADTYSYGIVLCEIVSRKDADPDEIPRNDNF TESK2_Hsap GLDYDAFQHM---VG-DCPPDFLQLTFNCCNMDPKLRPSFVEIGKTLEEILSRLQEEEQE TESK1_Hsap GLDVPAFRTL---VGDDCPLPFLLLAIHCCNLEPSTRAPFTEITQHLEWILEQLPEPAP- cdi_Dmel GLDYLAFVEL---CPMDTPPVFLRLAFYCCLYDAKSRPTFHDATKKLTLLLEKYEHESS- TESK1_Mmus GLDVPAFRTL---VGNDCPLPFLLLAIHCCSMEPSTRAPFTEITQHLEQILEQQPEATP- TESK2_Mmus GLDYDAFQNM---VG-DCPSDFLQLTFNCCNMDPKLRPSFEEIGKTLKEIMSRLPEEELE Tesk_Spur GLDLQLFKEK---CP-GIPEPFLQIAEDCCSMDPRDRPVFAELVRRFEIIRGTLDTETSD AqueK482_Aque --------------------------------DPDGRPTFDEIVQMLDPLVSAYQSNST- AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque SLNEAAFRELPEVIGSPCPPAFIDLACNCSKFVPDERPGFPIIPH-PPAIMTNLRENYLV TESK2_Hsap RDRK--LQPTARGLLEKAPGVK-------------------------------------- TESK1_Hsap ---------L-----TRTALTH-------------------------------------- cdi_Dmel ---------AGASPLSSLELINCSPGGSDSENVTLTPRASVPTVATICTAPAGTLTPRHL TESK1_Mmus ---------LAKPPLTKAPLTY-------------------------------------- TESK2_Mmus RDRK--LQPTAKGPLEKVPGGK-------------------------------------- Tesk_Spur TT-CY------DVNLTDIIRTN----------------------------DS-------- AqueK482_Aque --------PPPAPPIA--PLSN----------------------------------PSSP AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque LLQSLEVDPV-------LPFLY----------------------------AEGL-----L TESK2_Hsap ------------------------------------------------------------ TESK1_Hsap ------------------------------------------------------------ cdi_Dmel QEVDEDGFRFPSKKS------ASAALPGTPN----------------------------- TESK1_Mmus ------------------------------------------------------------ TESK2_Mmus ------------------------------------------------------------ Tesk_Spur --DDDD-------------------DDCS------------------------------- AqueK482_Aque SKVELPAELCPSPQS--------------------------------------------- AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque TRAEYDRLQSPEMMAQDRKTRADHLLRLLPNKGKNYFQKFCICIGKSGQIELLEKIGFDL TESK2_Hsap --------RLSSLDDK-IP---------------------------------HKSPCPR- TESK1_Hsap --------NQGSVARG-GP---------------------------------S-ATLPR- cdi_Dmel -----GSAGSSGFDDH-ILKSRVRRATQKLEAEILLHRRSLSENIIHFPM--HTSPSDK- TESK1_Mmus --------NQGSVPRG-GP---------------------------------S-ATLPR- TESK2_Mmus --------RLSSLDDK-IP---------------------------------HKSPRPR- Tesk_Spur ---FGFQ-FQTDLDDK-RR---------------------------------SGRTRLRE AqueK482_Aque ------------------------------------------------------------ AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque TLLPAEK-PLRTFENQSGPARESDRLKPVQIHLQGAHFNPVPLIYQETTPTSQGEPTPKT TESK2_Hsap -----RTIWLSRSQSDIFSRKPPRTVS---------------------------VLDPYY TESK1_Hsap -----PDPRLSRSRSDLFLPPSPES----------------------------------- cdi_Dmel ----ARCHQMQRQRSSTHSPTPPRQLSSVQLPATSIPDPPPLPKPVPAVLTLRKVGDPQY TESK1_Mmus -----PDPRLSRSRSDLFLPPSPES----------------------------------- TESK2_Mmus -----RTIWLSRSQSDIFSHKPPRTVS---------------------------VLDPYY Tesk_Spur VLCGCSKGWMTNAEVDEQDCE-KSFVD---------------------------VLKEY- AqueK482_Aque ------------------------------------------------------------ AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque ----QRILIL-YSNDPQVSSLPPDVRH---------------------------TQDEYL TESK2_Hsap RPRDGAA-RTPKVNPFSARQDLMGGKIKFFDLPSKSVIS--LVFDLD---------A--- TESK1_Hsap -PPNWGD-NLTRVNPFSLREDLRGGKIKLLDTPSKPVLP--LVP--P---------S--- cdi_Dmel KPTSEKDHNGSKPNPFEALAQLRGVK-KILDANPKTYAA--GVGDLFSSC--FEMLAPFF TESK1_Mmus -PPSWGD-NLTRVNPFSLREDLRGGKIKLLDTPCKPATPLPLVP--P---------S--- TESK2_Mmus QPRDGAT-HTPKVNPFSARQDLKGGKVKFFDLPSKSVIS--LVFDLD---------A--- Tesk_Spur --------------AYAARQYFRV--------VTGFIVC--LLPML-------------- AqueK482_Aque -P------------SSSLLSSLLGGSVERDGIIRERKIS--TVSLDSGCGPERVDPSSYW AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque KRVSDFV-QTLQM--FS--------TVSGTDGRSYSA--YKCIYDVDES---------QR TESK2_Hsap ------------PGPGT--MPLADWQEPL----APPIRRWRSLPGSPEFLHQEACPFVGR TESK1_Hsap ------------PFPSTQ-LPLVTTPETLVQP-GTPARRCRSLPSSPELPRRMETALP-- cdi_Dmel KELAAMQSKAGAQGGGTSTEETSTGN--KAS-AAT-PSEPKSLPVSPHMTRKYSAIELRL TESK1_Mmus ------------PLTSTQ-LPLVTTPDILVQP-ETPVRRCRSLPSSPELPRRMETALP-- TESK2_Mmus ------------PGPGS--TTLADCQEPL----AMSSRRWRSLPGSPEFLHQ-ACPFMGC Tesk_Spur ----------------------S------------------------------------- AqueK482_Aque KNI-----------GFYKTPSLTDGK---TTPLTPSSTHFRQISDSSEVSFQLPS----- AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque EHI--------------------------------------------------------- TESK2_Hsap E--------ESLSDGPPPR-LS--SL-------KYRVKEIP------------------- TESK1_Hsap --------------GPGPPAVG-PSAEEKMECEGSSPEPEP------------------- cdi_Dmel PQRISNAAPPAVTSAPPPS-IALPT-DE-DDCDDCNSEGEDPDGGGNCADAESSSDDSAV TESK1_Mmus --------------GPGPSPMG-PT-EERMDCEGSSPEPEP------------------- TESK2_Mmus E--------ESLSDGPPPR-LS--SL-------KYGVREIP------------------- Tesk_Spur ------------------------------------------------------------ AqueK482_Aque ---------PSFAWAPPPS-PST------------------------------------- AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque ------------------------------------------------------------ TESK2_Hsap --------------------PFR----------------ASALP------------AAQA TESK1_Hsap --------------------PGP----------------APQLP------------LAVA cdi_Dmel RPSTVPTARKYRANSLYAHPLFRGSNGTSMKSTSTGEFESPTLLKASASTITLTASVGAT TESK1_Mmus --------------------PGL----------------APQLP------------LAVA TESK2_Mmus --------------------PFR----------------TSALS------------AASG Tesk_Spur ----------------------------------------------------------LW AqueK482_Aque --------SLYRLSLT---SPID----------------TPSHQ------------VGAS AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque ------------------------------------------QN------------FNVW TESK2_Hsap HE-A--MDCSILQEE----------------------NG--------------------- TESK1_Hsap TD-NFISTCSSASQPWSPRSGPVLNNNPPAVV-VNSPQG--------------------- cdi_Dmel NSCEDLTESARKSKE-QASSGATAAVQALPTP-MSGC-S--------------------- TESK1_Mmus TD-NFISTCSSASQPWSPRSGPPLNNNPPAVV-VNSPQG--------------------- TESK2_Mmus HE-A--MDCSNPQEE----------------------NG--------------------- Tesk_Spur MY-CDLNNVLLWTSLIYASIGLVLENSTRCVEVLHSSQSIFRTLFNLISRLFSRLWNVVS AqueK482_Aque RE------GSLSSPEHSPITGEDSDHTPSPDP-ISGN-Q--------------------- AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque SF-ENLETCDAIILLMSPSIGEVLRGRSPVLE-MEKGVADSHTLINVLPR-----KRVIP TESK2_Hsap -----FGSRPQG-------------------------------TS--------------- TESK1_Hsap -----WAGEPWNRA-----------------------------QH--------------- cdi_Dmel -----TRLVETPVS-----------------------------VS--------------- TESK1_Mmus -----WAREPWNRA-----------------------------QH--------------- TESK2_Mmus -----FGPRLKG-------------------------------TS--------------- Tesk_Spur LLL----------QRVHCTRSAGSDLN-----------------ENVTYPNQNGGPTKSL AqueK482_Aque -----FDLEDWNII-----------------------------RA--------------- AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque VYLNMPKVADWLPVFLKSTPSYFIDLLGFQSGMSTVTSEEEFGR---------------- TESK2_Hsap ------------PCP-AG------------------------------------------ TESK1_Hsap ------------SLPRAA------------------------------------------ cdi_Dmel ------------SCTDLELDELKNTCDLNELKNSCEQLPLKTNLTRRDSIESGFFSCFNE TESK1_Mmus ------------SLPRAA------------------------------------------ TESK2_Mmus ------------LCT-GA------------------------------------------ Tesk_Spur QHGDTPSEVLRNTSTR-------------------------------------------- AqueK482_Aque ------------TCTNMS------------------------------------------ AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque ------------------------------------------------------------ TESK2_Hsap ------------------------------------------------------------ TESK1_Hsap ------------------------------------------------------------ cdi_Dmel ESDAAITNNSFGRQLNGIGSLGFGCGGGGNSSNCCYEKLKTQLMLDACVSADSEINDKLA TESK1_Mmus ------------------------------------------------------------ TESK2_Mmus ------------------------------------------------------------ Tesk_Spur ------------------------------------------------------------ AqueK482_Aque ------------------------------------------------------------ AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque ------------------------------------------------------------ TESK2_Hsap ------------------------------------------------------------ TESK1_Hsap ------------------------------------------------------------ cdi_Dmel SLCRCCYYATSTSNAAVTAAAAAAQQQQQSHLLNDTSSTSSSVLLIDNDPAVIGGNTSSS TESK1_Mmus ------------------------------------------------------------ TESK2_Mmus ------------------------------------------------------------ Tesk_Spur ------------------------------------------------------------ AqueK482_Aque ------------------------------------------------------------ AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque ----------------------------------------RSYLLLDEDPNL-------- TESK2_Hsap ------------------------------------------------------------ TESK1_Hsap ------------------------------------------------------------ cdi_Dmel TALDSMDDLDADIVASRRTHQRRYTCHHALLSGNGSESQMAATASLINRLALDSEIHTLL TESK1_Mmus ------------------------------------------------------------ TESK2_Mmus ------------------------------------------------------------ Tesk_Spur ------------------------------------------------------------ AqueK482_Aque ------------------------------------------------------------ AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque ------------------------------------------------------------ TESK2_Hsap ------------------------------------------------------------ TESK1_Hsap ------------------------------------------------------------ cdi_Dmel QRSPFATNQLLYCKNRTSSIYTDSSDDISSLAGSDSLLWDDRSFTALPSTRSAQIAKIVE TESK1_Mmus ------------------------------------------------------------ TESK2_Mmus ------------------------------------------------------------ Tesk_Spur ------------------------------------------------------VADLVP AqueK482_Aque ------------------------------------------------------------ AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque ----------------------------------------------------KEMRDLL- TESK2_Hsap ASEEMEVEE--------RPAGSTPA----------------------------------- TESK1_Hsap ALERTE--P--------SPPPSAPREPDEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYR cdi_Dmel YFERKRQD---------SSPPSVHHRNGNGTVAAAVAASALGSNYLSYESRRYSDFKRHL TESK1_Mmus ALERTE--P--------SPPPSAPREPEEGLPCPGCCLGPFSFGFLSMCPRPTPAVARYR TESK2_Mmus ASEEMEVEE--------ERPRRASV----------------------------------- Tesk_Spur ILKNRQ--K--------GPGPGAEDPESQGARKKTLL----------ANELEETELDKLH AqueK482_Aque LVEE-EEE---------EGGGGGILTDRDG------------------------------ AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque AVLRREPPPENPTTVFAVPPPKSSDLKSQGIPT----------KYLDLVTRMIPHIWDRV TESK2_Hsap ----------------------------------------------------------TF TESK1_Hsap NLNC--------------------------------------------EAGSLLCHRGHH cdi_Dmel NADGL----------------------------------CFDLDKKPAQQRMMVCEGAVK TESK1_Mmus NLNC--------------------------------------------EAGSLLCHRGHH TESK2_Mmus ----------------------------------------------------------YF Tesk_Spur NPNIN----------------------------------------RVLLNGRMSQKRVSF AqueK482_Aque ---------------------------------------------RER-----IERRPLF AqueK483_Aque ------------------------------------------------------------ AqueK484_Aque GLKLGFTLMEIESIRSRNKDDPEQSIHSMFSKWQERDGAEATIDILIKVLQELRLNGVVY TESK2_Hsap -STSGIGLQTQGKQDG TESK1_Hsap AKPPTPSLQL-PGARS cdi_Dmel SKLP-IFDKKKQQQGG TESK1_Mmus AKPPTPSLQL-PGARS TESK2_Mmus -SISGISLQTQAKQDG Tesk_Spur -SLQNSIDRDEGDPNP AqueK482_Aque NR---TSCSTPNLQTC AqueK483_Aque ---------------L AqueK484_Aque -KVKAEVEKDKQKEKK