CLUSTAL W (1.83) multiple sequence alignment Spk389_Spur MSDIS-PNRRLFESLLKKDNTPIFSRDIIKDANIGAQELPDFIVR--------------- Spk374_Spur MDSSNIRRLRL--RDRVD-YTPAFC-DVISQGDYIVQ----------------------- Spk377_Spur MCGFL-RFVRG--RFRNSSNRPILSRNNINESKNGTKKELDHIILTSVENDPLKFRPVPE Spk362_Spur MSGFL-RFVGG--IVRNSSNRPILSRDIINEAKIRTK----------------------- Spk363_Spur MCGFL-RFVRG--RFRNSSNRPILSRNNINESKNGTKKTLDHIILKTVVNDPLKSRPVPE Spk208_Spur MTRFM-YALRV--ASI-----YA------------------------------------- Spk381_Spur MMRFM-YALRV--ASI-----YA------------------------------------- Spk364_Spur ------------------------------------------------------------ Spk396_Spur MMRXVVYALRV--ASI-----YA------------------------------------- Spk397_Spur MMRFI-YALRV--ASI-----YA------------------------------------- Spk398_Spur MMRFM-YALRV--ASI-----YA------------------------------------- Spk399_Spur MMRFM-YALRV--ASI-----YA------------------------------------- Spk389_Spur ------------------------------------------------------------ Spk374_Spur ------Q--------------VRAFYS--------------------GLYGVQANRLR-- Spk377_Spur KVEDVDQVYSIEHRI--------------------------------------------- Spk362_Spur ------------------------------------------------------------ Spk363_Spur KVEDVDQAYSIEHRIKALVIEMGDHRALTNADVMMTRLEGAWHLQQESHHD-LANQYDTL Spk208_Spur ----------------------------------------------------LANAL--- Spk381_Spur ----------------------------------------------------LANTL--- Spk364_Spur ------------------------------------------------------------ Spk396_Spur ----------------------------------------------------LANAL--- Spk397_Spur ----------------------------------------------------LANAL--- Spk398_Spur ----------------------------------------------------LSNAL--- Spk399_Spur ----------------------------------------------------LANAL--- Spk389_Spur ------------AQSTIKSPAAPPMIIFRMN-----------GMTLWNCSKNVKISEVAA Spk374_Spur ------------------------------------------------------------ Spk377_Spur ----KTFARDIGLDTDIASSDDVLMIITNLDQRWCQIQNQLREVTGALDSKNTRVKELAA Spk362_Spur -----TYAREIRLDTDIASSDDVLMIITNLDQRWRQIQNQLREVTGALDSKNTRVMELAS Spk363_Spur VNKLRTFARDIGLDIDIASSDDILMIITNLDQRWRQRQNQLREVTGALDLKNTQVKELAA Spk208_Spur ------------------------------------------------------------ Spk381_Spur ------------------------------------------------------------ Spk364_Spur ------------------------------------------------------------ Spk396_Spur ------------------------------------------------------------ Spk397_Spur ------------------------------------------------------------ Spk398_Spur ------------------------------------------------------------ Spk399_Spur ------------------------------------------------------------ Spk389_Spur DLGLSDALSETDTYDVTTADL--------------------------------------- Spk374_Spur H------DDVIKSIQDMRGSQ---------------NHL-LL-QLQESAAILGIDLYNGT Spk377_Spur FLGMKTPVTESSVFDDVMVRWTDKHSKFNDLQKALQEKQEESREASQTLQNTAKLMG--- Spk362_Spur FLGVKTPVTESSVFDDVMVRWTDQQSKFNDLQKALQEKQEDSRETSQSLQNIAKLMG--- Spk363_Spur FLGVKTPVTESSEFDDIMVRWTDQQSKFNDLQKALQEKQEDSREASQALQNIAKLMG--- Spk208_Spur --------ELCRSFQDPSFSP--------------------------------------- Spk381_Spur --------ELCSSFKDPSFSL--------------------------------------- Spk364_Spur ------------------------------------------------------------ Spk396_Spur --------ELCRSFQDPSFSL--------------------------------------- Spk397_Spur --------ELCRSFQDPSFSL--------------------------------------- Spk398_Spur --------ELCRSFQDPSFYL--------------------------------------- Spk399_Spur --------ELCRSFQDPSFSL--------------------------------------- Spk389_Spur -------------------DRVISIPMQIPRVWHF------------------------- Spk374_Spur GPFSQTVTENGWKMGTHKDVA----TNTL------------------------------- Spk377_Spur ---------------VVRPEKKDALSDSIGGIWTRSQKQITDLQQELFQQKDQIQRSGEQ Spk362_Spur ---------------VVRPEKKDALPGSIGGIWTRSQKQITDLQQELFQQKEQIQRSGEQ Spk363_Spur ---------------VVRPEKTDALSDSIGGIWTRSQEKITDLQQELFQQKEQIKQSGKQ Spk208_Spur -------------------------PSTI------------------------------- Spk381_Spur -------------------------PSTI------------------------------- Spk364_Spur ------------------------------------------------------------ Spk396_Spur -------------------------PSTI------------------------------- Spk397_Spur -------------------------PSTI------------------------------- Spk398_Spur -------------------------SSAI------------------------------- Spk399_Spur -------------------------PSTI------------------------------- Spk389_Spur -------------------------------------EPGQLTTQITQHKLD-------- Spk374_Spur --------------------------------QASEGFDGNLRKGVLQSVNSKSIPFKSA Spk377_Spur LQDLAKIFGAVSTSVDGTNVLDAISEKREEMKSLISQLRSSLLVEKDQNSKAHE------ Spk362_Spur LQNVARIFGVALTHVDGTNILDAISVKWEEMKSLTSHLRSSLLVEKDQNNKAHE------ Spk363_Spur LQNVARIFG-----VDGTNIPDAISVKWEEMKALTSQLRSSLLVEKDQNNKAHE------ Spk208_Spur --------------------------------SPTQAMSGKLLLKYLQNNLEKE------ Spk381_Spur --------------------------------SPIPAMSGKLLLKYLQNNLEKE------ Spk364_Spur ------------------------------------------------------------ Spk396_Spur --------------------------------SPTPAMSGKLLLKYLQNNLEKE------ Spk397_Spur --------------------------------STTPAMSGKLLLKYLQNNLEKE------ Spk398_Spur --------------------------------SPTPAMSGKLLLKYLQNNLEKE------ Spk399_Spur --------------------------------SPTPAMSGKLLLKYLQNILEKE------ Spk389_Spur --------------------------------LVTKRIRDLNDTLGLQPYACTSSILVMM Spk374_Spur QQICGQKYSLSHRLIKPGDLKVTTSHAETSPSGLQREWCTIPSE--SHTDGQRQCLLCRP Spk377_Spur --------------------------------TLQ----GVADFMGVETSGCESTIVGGM Spk362_Spur --------------------------------TLQ----GLAHFMGVETSGCESTIVSGL Spk363_Spur --------------------------------TLQ----GVASSMGVEMSGCGSTIVGGM Spk208_Spur --------------------------------QLQQGIASLATQLGVRADGDSTALLTKI Spk381_Spur --------------------------------QLQQGIASLATQLGVKADGDSAALLTKI Spk364_Spur ------------------------------------------------------------ Spk396_Spur --------------------------------QLQQGIVSLATQLGVRADGDSTALLTKI Spk397_Spur --------------------------------QLQQGIASLATQLGVGADGDSAALLTKI Spk398_Spur --------------------------------QLQQGIVSLATQLGVRADGDSTALLTKI Spk399_Spur --------------------------------QLQQGIASLATQLGVRADGDSTALLTKI Spk389_Spur --------------------------VDKLSRAHRSAVCLYTILEAERRQA--EE--TQG Spk374_Spur CDFTSLLGPDAYILSTSTSEEDWCSASSHIMEASVPRMG------LLKP----CDFKLSK Spk377_Spur --------------------------MDRWTENRREVIE------LQR------------ Spk362_Spur --------------------------KDRWTENRREVIE------LQR------------ Spk363_Spur --------------------------MDRWTENRREVIE------LQR------------ Spk208_Spur --------------------------SSLVTESERRRVS------AERRAKAFEERYLDQ Spk381_Spur --------------------------SSLVTESERRRVS------AERRAKAFEERYLDQ Spk364_Spur ------------------------------------------------------------ Spk396_Spur --------------------------SSMVTESERRRVS------AERRAKAFEERYLDQ Spk397_Spur --------------------------SSLVTESERRRVS------AERRAKAFEERYLDQ Spk398_Spur --------------------------SSLVTESERRRVS------AERRAKAFEERYLDQ Spk399_Spur --------------------------SSLVTESERRRVS------AERRAKAFEERYLDN Spk389_Spur ALQKQIEELETGLEEERRQATSSKDAQQKHVDELESRLEDEKRASRQAQDELLSHLS-K- Spk374_Spur SIGYSSMNS--SLEE-DKF----PTASLANIQTSLHRACLLRPCDM-GLSTHQNLFSSET Spk377_Spur -----------ALKDEREK----TKQAQEALMDHLSRP---------DPVLASTVTQT-- Spk362_Spur -----------ALKEEREK----TQQAQEAFVDHILRP---------GPVLASVATQT-- Spk363_Spur -----------ALMEEREK----TKQAQEALMDHLCRP---------GPVLVSVVTQT-- Spk208_Spur AMNFQVLEL--ELAETRKQ----KDAALKNLQDLTWEPTVLSPADS-GPSTCVSWCSG-- Spk381_Spur AMKAQVLEL--ELAETRKQ----KDAALKNLQDLTWQPTVLSPADS-GPTTCVSWCSG-- Spk364_Spur ------------------------------------------------------------ Spk396_Spur AMNGQVLEL--ELAEARKQ----KDAALKNLHDLTWQPTVLSPVDS-GPSTCVSWCSR-- Spk397_Spur AMKDQVLEL--ELAETRKQ----KDIALKNLQDLTWQPTVLSPADG-SLTSRVSWCSG-- Spk398_Spur AMNGQVLEL--ELAEARKQ----KDAALKNLQDLTWQPTVLSPADS-GPSTCISWCSG-- Spk399_Spur TMNGQILEL--ELAEARKQ----KDAALKNLQDLTWQPTVLSPADS-GPSTCVSWCSG-- Spk389_Spur -----------------------------------HLQTSGTQT-DNEI----SVPSSSS Spk374_Spur SPKQDWFSVSSHTNETRLYQICLLRPVDISSSLSENPTSPSELDVE------QDWF---- Spk377_Spur ----------------------------------DDHQAQSEGQLCH------KDPLIFG Spk362_Spur ----------------------------------DDHQAQSEAQLCHKS--SDRDPLIFG Spk363_Spur ----------------------------------DDHQAQSESQLCDKSVQRDRDPLIFG Spk208_Spur ----------------------------------DNPQTPSTAPLYNGV--APTHP---- Spk381_Spur ----------------------------------DNSQTPSTAPLDNAV--APTHP---- Spk364_Spur ------------------------------------------------------------ Spk396_Spur ----------------------------------DNPQTPSTAPLDNGV--APTYP---- Spk397_Spur ----------------------------------ENSQTPSTAPLDNGV--APTHP---- Spk398_Spur ----------------------------------DNPQTPSTAPLDNGV--VPTHP---- Spk399_Spur ----------------------------------VNPQTPSTAPLDNGV--APTHP---- Spk389_Spur SQEVD----------------PSAAISEEIFYDAL------------------------- Spk374_Spur ----------------------STSSQPKFSSLPLLRPRDITTTGSQDVSSTQKNSPLPR Spk377_Spur EAEQELQQIKEHLSLSISYRSHSFTLSASRDLIHL------------------------- Spk362_Spur KAEQELQQIKEHLSLSIPYRSHSFTLSASRDLIHV------------------------- Spk363_Spur KAEQELQQIKEHLSLSISYRSHSFTLSASRDLIHL------------------------- Spk208_Spur ----------------------STPSTAPIDTIPL------------------------- Spk381_Spur ----------------------STPSTAPIDTIPL------------------------- Spk364_Spur ------------------------------------------------------------ Spk396_Spur ----------------------STPSTAPIDTIPL------------------------- Spk397_Spur ----------------------STPSTAPIDTTPL------------------------- Spk398_Spur ----------------------STPSTAPIDTIPL------------------------- Spk399_Spur ----------------------STPSTAPIDTVPL------------------------- Spk389_Spur ----------------------TTIDDDQAPDISEDIFYDALSTIGDNQSGARAKEIFYD Spk374_Spur KLHLVRPCDLTKSSSTSHEVTFSSRKPDTSPLISTY---------LSAS----------- Spk377_Spur ----------------------GPRCRSLKT----------------------------- Spk362_Spur ----------------------SLCYKSLKT----------------------------- Spk363_Spur ----------------------GPRCRSLRT----------------------------- Spk208_Spur ----------------------SLIPPSPSPWASGP---------GTHP----------- Spk381_Spur ----------------------PLIPPSPGPWVSGP---------GTPP----------- Spk364_Spur ------------------------------------------------------------ Spk396_Spur ----------------------SLIPSSPSPWASGP---------GTPP----------- Spk397_Spur ----------------------PLIPPSPGPWASGP---------G-------------- Spk398_Spur ----------------------SLIPPSPSPWASGP---------G-------------- Spk399_Spur ----------------------SLIPPSRSPLVSGP---------GTPL----------- Spk389_Spur ALTTIDDNQSGARTKEIFYDAFSTSPRKIPP---------------VFIEAVDALEFDAV Spk374_Spur ----------------------SHLPDSFHESVYSSASLGHDDWSVTKEGSPLPVRYLHR Spk377_Spur --------------------------------------------------------LRAG Spk362_Spur --------------------------------------------------------LRAG Spk363_Spur --------------------------------------------------------LRAG Spk208_Spur ----------------------TGTPLTVP----------------LPAQAPVVLQLTPH Spk381_Spur ----------------------SGTPPTVP----------------LPAQAPMVLQLTPY Spk364_Spur ------------------------------------------------------------ Spk396_Spur ----------------------AGTPLTVP----------------LPAQATVVLQLTPH Spk397_Spur ------------------------TPLTVP----------------LPAQAPVVLQLTPH Spk398_Spur ------------------------TPLTVP----------------LTTQAPVVLQLTPH Spk399_Spur ----------------------AGTPLTVP----------------LPAQAPVVPQLTLH Spk389_Spur KAFVPWSSLRLDRFLDKTIEISNSDLDAAK------ATPK------------------SK Spk374_Spur TTS-------------YSCRS--SGSWGQSTSMSS-SVSPGFSPVKRYPDLVEQTLASIF Spk377_Spur DAF-------------RPPSR--TSLLRGVSAIANT-------------------ISCLE Spk362_Spur DAF-------------RPPSM--TSLLRGVSAIDST-------------------ISCLE Spk363_Spur DAF-------------RPPSR--TSLLRGVSAIDST-------------------ITCLE Spk208_Spur TAS-------------RSPKV--SAPDGGTTSPSSRAAVP------------------AQ Spk381_Spur TAS-------------RSLKV--SAADSGTTLPLSRAAVP------------------AQ Spk364_Spur ------------------------------------------------------------ Spk396_Spur TAS-------------QSPKV--SAADGGTTSPSSRAAVP------------------AQ Spk397_Spur TAS-------------RSPKV--SAVDGRTTSPSSRAAAP------------------AQ Spk398_Spur TAS-------------RSPKV--SAADGGTTSPSSRAAVP------------------AQ Spk399_Spur TAS-------------RSPKV--SAADVGTTSPSSRAAVP------------------AQ Spk389_Spur GKAKAGTIVKRMRDLVPFREP-NSSIELGSGTAGTVYLYRHAKTNEPVALKVIALPPSGV Spk374_Spur LP-HTSSFVRSLDDLESWNPSGHGGSELGRGVYGAVHLYSHKQTGQAVAVKVITLPKEYT Spk377_Spur PPCNSNMMVSNMSDLIPWAES-RCSIELGRGVAGTVYLFRHAVSKIPVAAKLVEYPGE-- Spk362_Spur SPCNSNMMVSNMSDLIPWTES-RCSIELGRGVTGTVYLFRHAVLKIPVAAKLVEYAGK-- Spk363_Spur PPCNSSMMVSNMSDLIPWTET-RCSIELGRGVAGTVSLFRHAVSKIPVAAKLVEYPGE-- Spk208_Spur GP-SASSYVWGMSDLMSFHKG-GSDVFLGSGANGTVHLYRHRATDHPIALKTFELPDDIK Spk381_Spur GP-SASSYVWGMSDLTSFHQG-GGDVFLGSGANGTVHLYRHRATDHPIALKTFELPNDIK Spk364_Spur -----------MSDLIPWAET-RCSIELGRGVAGTVFLFRHAVSKIPVAAKLVEYPGE-- Spk396_Spur GP-SASSYVWGMSDLMSFHKG-GSDVFLGSGANGTVHLYRHRATDHPIALKTFELPNDIK Spk397_Spur GP-SASSYVWGMSDLMSFHKG-GGDVFLGSGANGAVHLYRHRATDHPIALKTFELPDEIK Spk398_Spur GP-SASSYVWGMSDLMSFHKG-GGDIFLGSGANGTVHLYRHRATDHPIALKTFELPDDIK Spk399_Spur GP-SASSYVWGTSDLMSFHKG-GGDVFLGSGANGTVHLYRHRATDHPIALKTFELPNDIK ** .: . ** *. *:* *: * .:* * . . . Spk389_Spur DGNKKSAIEKLQNEMKILQRLGCTEWFPEFYGCCKVCKDVVGIAMEFCGDVEKGESYSIL Spk374_Spur KRR--ATISLFKKEVQFQELVSKSPYFPKLYGCFRLDEDKVGMAMEFVGDEVTGKSTTLL Spk377_Spur ---------CFRNEVRIHQAISGLPWFPTFYGSFDIDGDQSVLAMEFVGSESEDRSYTIT Spk362_Spur ---------YFRNEVRIHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIGSESEDRSYTIT Spk363_Spur ---------CFRNEVRIHQAISGLPWFPTFYGSFDIEGDQAVLAMEFIGSESEDRSYTIT Spk208_Spur AMT--RKVKAIQSEAFILDVLGREDCFPTFLGCLEISPGKIGLAMDFVGDTMTGESWTLS Spk381_Spur AMT--RKVNAIQSEAFILDVLGREDCFPTFLGCLEISTGKIGLAMDFVGDTMTGESWTLS Spk364_Spur ---------CFRNEVRIHQAISGLPWFPTFYGSFDIADDQTVLAMEFVGNKSED------ Spk396_Spur AMT--RKVNAIQSEAFILDVLGREDCFPTFLGCLEISTGKIGLAMDFVGDTMTGESWTLS Spk397_Spur AMT--RKVTAIQSEAFILDVLGREDCFPTFLGCLEISTGKIGLAMDFIGDTMTGESWTLS Spk398_Spur AMT--RKAKAIQSEAFILDVLGREDCFPTFLGCLEISPGKIGLAMDFVGDTMTGESWTLS Spk399_Spur SMT--RKATAIQSEAFILDVLGREDCFPTFLGCLEISPGKIGLAMDFVGDTMTGESWTLS ::.* : : :. ** : *. : . :**:* *. . Spk389_Spur NC-IDG----KGPKLDKDAWMNVMLDIADGLTVMHKKGFLCNDLKEDNVLLVK-SGGEWR Spk374_Spur KA-LEV----RQPALTRYQMLLIAVDVAEGLRVLHDQGILINDLKNDNILIRK-EFGRWR Spk377_Spur DC-LEKSMLKTGPDLTRDEWFYVLNGVAEGLKALHSKGFLCNDLKEDNVLVVE-ESGLWR Spk362_Spur DC-LEKSMLKTGPDLTRDEWFDVLNDVAEGLKALHTMGFLCNDLKEDNVLVVE-ESGRWR Spk363_Spur DC-LEKSMLKTGPDLTRDEWFGVLNDVAEGLKALHSNGFLCNDLKEDNVLVVE-ESGRWR Spk208_Spur RG-M------RKLALSQQDWLALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQ Spk381_Spur RG-M------RKLALSQHDWFALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQ Spk364_Spur ----------------------------QGLKALHSNGFLCNDLKEDNVLVVE-ESGLWQ Spk396_Spur HG-M------RKLALSQHDWFALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQ Spk397_Spur RG-M------RELALSQHDWLALALDIAKSLGCIHEKGFLMNDLKEDNCLLRKTPTGRWQ Spk398_Spur RXGM------RKLALSQQDGLALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQ Spk399_Spur RG-M------RNLALSQQGWLALALDIAKSLGRIHEKGFLMNDLKEDNCLLRKTPTGRWQ ..* :* *:* ****:** *: : * *: Spk389_Spur AKIIDFGWSSDMNMLFPACRMPFTARQKRDYKYRHAYNYIAPECALKGKSFSQSSDVYSL Spk374_Spur GVLIDLGYACILQDPV---RFHFSQREKQEYLTIGRYGHIAPELAISEQPATIASDVFQV Spk377_Spur AKIIDLGWASAIATPF---VMPLDEEQIDFYRSGRGCCHIAPECVLDARPCSTSSDVYSL Spk362_Spur AKIIDLGWASEIATPF---VMPLDEEQIDFYRSGRGCCHIAPECVLEARPCSTSSDVYSL Spk363_Spur AKIIDLGWASEIATPF---VMPLDEEQIDFYRSGQGCGHIAPECVLDASPCSTSSDVYSL Spk208_Spur AVIVDFGLACPCDAPY---FYRFSDENKEKYRRREVYVHIAPECALDDVLTSVSSDVFQL Spk381_Spur AVIVDFGLACPCDRPY---FYRFSAEVKEKYRRKEVYVHIAPECALDDVLTSVSSDVFQL Spk364_Spur TKIINLGWASEIATPF---VMPLDEEQIDFYRSCRGCCHIAPECVLDARPCSTSSDVYSL Spk396_Spur AVIVDFGLACPCDRPY---FYRFSDEVKEKYRRREVYVHIAPECVLDDVLTSVSSDVFQL Spk397_Spur AVIVDFGLACPCDRPY---FYRFSDEDKEKYRRKEVYVHIDPECALDDVVTSVSSDVFQL Spk398_Spur AVIVDFGLACPCDAPY---FYRFSDENKEKYRRREVYVHIAPECALDDVLTSVSSDVFQL Spk399_Spur AVIVDFGLACPCDAPY---FYRFSNENKEKYRRREVHVHIAPECALDDRLTSVASDVFQL ::::* :. : . * :* ** .:. : :***:.: Spk389_Spur GRLAAFVGQEVPGLKELGDYGFNIYSSPRGKRPSLQKFSQEINYLR-SRTNESDSDEDLV Spk374_Spur GAVYIGLGQCFQ-MNELHQLGCICCSIAPSQRPTLDAILQCLGEIMKKY------YQHQE Spk377_Spur GRLLAMVGRAMR-YDDFECFGTQIYLADEDQRPTVQEIIDQLYEMQLVQGGEDDPESSSC Spk362_Spur GRLLAIIGRAMR-DDDFECFGTQIYLADEEHRPTVQEILDEIQPVY-IEEGDDGPGSSSC Spk363_Spur GRFLAIVGHAMR-YDDFECFGTQIYLTDEGQRPTVQEIIDQLYNMQLVEGGEDDPESSSC Spk208_Spur GRLLTLMGGATT-NADLTAIGNICRQSSKLCRPSIDEVVAELERM--------------M Spk381_Spur GRLLALMGRATT-NADLTAIGNICRQSSQLCRPSIDEVVAELARM--------------M Spk364_Spur GRLLASIGRAMR-YDDFEFSSTQIYLADEEQRPTVQEIIDQLYKMRLAAEGEDGPGSSSC Spk396_Spur GRLLTLMGGATT-NADLTAIGNICRQSSQLCRPSIDEVVAELERM--------------M Spk397_Spur GRLLTLMGGATT-NADLTAIGNICRQSSQLCRPSIDEVVAELERM--------------M Spk398_Spur GRLLTLMGGATT-NADLTAIGNICRQSSQLCRPSIDEVVAELRRM--------------M Spk399_Spur GRLLTLMGGATT-NADLTAIGNICRQSSQLCRPSIEEVVAELERM--------------M * . :* :: . **::: . : :