Gene Name VAIK motif HRD motif DFG motif vaiK? hrD? Dfg? Predicted Active? Notes ErbB3 VCIK HRD DFG Yes Yes Yes ? "Predicted active, but human ortholog inactive and 'fixing' the missing residue does not restore biochemical activity" ANPa VAVK HGN DYG Yes No Yes No ANPb VAIK HGS DYG Yes No Yes No CASK FAVK HRD GFG Yes Yes No No CCK4 VLVK HKD ALG Yes Yes No No CYGD VWLK HGR DHG Yes No Yes No CYGF VWLK HGR DYG Yes No Yes No CYGX VWLK HGR DHG Yes No Yes No EphA10 VAVH HRG GFG No No No No EphB6 VAIQ HRA RLG No No No No Haspin VALK HRD LNG Yes Yes No No HSER VILK HGR DFG Yes No Yes No ILK IVVK RHA DVK Yes No Yes No IRAK2 FAFR RSN -HP No No No No IRAK3 YAVK CGN DFA Yes No Yes No KSGC VALC HGN GFG No No No No KSR1 VAIR HKD LFG No Yes No No KSR2 VAIR HKD LFS No Yes No No MarkmA10 HRG DFG No No Yes No "Missing start, disabled HRD" MarkmD3 VAVK HRN DFG Yes No Yes No MarkmE3 VAIK HRG DFG Yes No Yes No MLKL VTIK HRN -FE Yes No No No NRBP1 VVWN HGN VAP No No No No NRBP2 VVWN HGN ALP No No No No RSKL1 NS-- CRD YFS No Yes No No RSKL2 DAEP CRD YFG No Yes No No SCYL1 VAKA HNN DYM No No Yes No SCYL2 VAVF HGN DFC No No Yes No SCYL3 FVYK HNN GME Yes No No No SgK071 FLIK HRN DMS Yes No Yes No SgK196 VALS HHS QYL No No No No SgK223 VPSS HRD NFL No Yes No No SgK269 VPSR HCD NFS No Yes No No SgK307 HRS DSG No No Yes No SgK396 VLLK HGS DYD Yes No Yes No SgK424 No No No No SgK495 HRD NFC No Yes No No Slob LVLS YGH DLE No No Yes No STLK5 VTVR HRS GLR No No No No STLK6 VTVK HRS GLS Yes No No No SuRTK106 VVLK HGD HLG Yes Yes No No TBCK SIK HRA KFG Yes No No No Trb1 HYQD LGD SLE No Yes No No Trb2 CYQE LRD SLE No Yes No No Trb3 EAQA LRD NLE No Yes No No TRRAP YLVM LNRLN YFR No Yes Yes No HRD motif modified in PIKKs TTN FMAK HFD EFG Yes Yes No No ULK4 VAIL FCD NFC No Yes No No VACAMKL HTCK HRN DFH Yes No Yes No VRK3 HGN GYG No No No No zGCN2 WVLQ HKV DYS No No Yes No zJAK1 VILK HGN DPG Yes No Yes No zJAK2 GGIQ CKE DFA No No Yes No zJAK3 VLLK HGN DPG Yes No Yes No zTYK2 VVLK HGN DPG Yes No Yes No AAK1 CALK HRD DFG Yes Yes Yes Yes ABL VAVK HRD DFG Yes Yes Yes Yes ACK VAVK HRD DFG Yes Yes Yes Yes ACTR2 VAVK HRD DFG Yes Yes Yes Yes ACTR2B VAVK HRD DFG Yes Yes Yes Yes AKT1 YAMK YRD DFG Yes Yes Yes Yes AKT2 YAMK YRD DFG Yes Yes Yes Yes AKT3 YAMK YRD DFG Yes Yes Yes Yes ALK VAVK HRD DFG Yes Yes Yes Yes ALK1 VAVK HRD DLG Yes Yes Yes Yes ALK2 VAVK HRD DLG Yes Yes Yes Yes ALK4 VAVK HRD DLG Yes Yes Yes Yes ALK7 VAVK HRD DLG Yes Yes Yes Yes AMPKa1 VAVK HRD DFG Yes Yes Yes Yes AMPKa2 VAVK HRD DFG Yes Yes Yes Yes ANKRD3 LAIK HLD DFG Yes Yes Yes Yes ARAF VAVK HRD DFG Yes Yes Yes Yes ARG VAVK HRD DFG Yes Yes Yes Yes ATM QLVK LGDRH DLG Yes Yes Yes Yes HRD motif modified in PIKKs ATR MMCK LGDRH DFN Yes Yes Yes Yes HRD motif modified in PIKKs AurA LALK HRD DFG Yes Yes Yes Yes AurB VALK HRD DFG Yes Yes Yes Yes AurC VALK HRD DFG Yes Yes Yes Yes AXL VAVK HRD DFG Yes Yes Yes Yes BARK1 YAMK YRD DLG Yes Yes Yes Yes BARK2 YAMK YRD DLG Yes Yes Yes Yes BIKE CALK HRD DFG Yes Yes Yes Yes BLK VAIK HRD DFG Yes Yes Yes Yes BMPR1A VAVK HRD DLG Yes Yes Yes Yes BMPR1B VAVK HRD DLG Yes Yes Yes Yes BMPR2 VAVK HRD DFG Yes Yes Yes Yes BMX VAVK HRD DFG Yes Yes Yes Yes BRAF VAVK HRD DFG Yes Yes Yes Yes BRK VAVK HRD DFG Yes Yes Yes Yes BRSK1 VAVK HRD DFG Yes Yes Yes Yes BRSK2 VAIK HRD DFG Yes Yes Yes Yes BTK VAIK HRD DFG Yes Yes Yes Yes BUB1 CILK HGD DLG Yes Yes Yes Yes BUBR1 TMIK HGD DFS Yes Yes Yes Yes CaMK1a VAIK HRD DFG Yes Yes Yes Yes CaMK1b VALK HRD DFG Yes Yes Yes Yes CAMK1d FAVK HRD DFG Yes Yes Yes Yes CAMK1g FALK HRD DFG Yes Yes Yes Yes CaMK2a YAAK HRD DFG Yes Yes Yes Yes CaMK2b YAAK HRD DFG Yes Yes Yes Yes CaMK2d YAAK HRD DFG Yes Yes Yes Yes CaMK2g YAAK HRD DFG Yes Yes Yes Yes CaMK4 YALK HRD DFG Yes Yes Yes Yes CAMKK1 YAMK HRD DFG Yes Yes Yes Yes CAMKK2 YAMK HRD DFG Yes Yes Yes Yes caMLCK LAAK HLD DFG Yes Yes Yes Yes CCRK VALK HRD DFG Yes Yes Yes Yes CDC2 VAMK HRD DFG Yes Yes Yes Yes CDC7 IALK HRD DFG Yes Yes Yes Yes CDK10 VALK HRD DFG Yes Yes Yes Yes CDK11 YALK HRD DMG Yes Yes Yes Yes CDK2 VALK HRD DFG Yes Yes Yes Yes CDK4 VALK HRD DFG Yes Yes Yes Yes CDK5 VALK HRD DFG Yes Yes Yes Yes CDK6 VALK HRD DFG Yes Yes Yes Yes CDK7 VAIK HRD DFG Yes Yes Yes Yes CDK8 YALK HRD DMG Yes Yes Yes Yes CDK9 VALK HRD DFG Yes Yes Yes Yes CDKL1 VAIK HRD DFG Yes Yes Yes Yes CDKL2 VAIK HRD DFG Yes Yes Yes Yes CDKL3 VAIK HRD DFG Yes Yes Yes Yes CDKL4 VAIK HRD DFG Yes Yes Yes Yes CDKL5 VAIK HRD DFG Yes Yes Yes Yes CHED VALK HRD DFG Yes Yes Yes Yes CHK1 VAVK HRD DFG Yes Yes Yes Yes CHK2 VAIK HRD DFG Yes Yes Yes Yes CK1a VAVK HRD DFG Yes Yes Yes Yes CK1d VAIK HRD DFG Yes Yes Yes Yes CK1e VAIK HRD DFG Yes Yes Yes Yes CK1g1 VAIK YRD DFG Yes Yes Yes Yes CK1g2 VAIK YRD DFG Yes Yes Yes Yes CK1g3 VAIK YRD DFG Yes Yes Yes Yes CK2a1 VVVK HRD DWG Yes Yes Yes Yes CK2a1-rs VVVK HRD DWG Yes Yes Yes Yes CK2a2 VVVK HRD DWG Yes Yes Yes Yes CLIK1 VAVK HRD DFG Yes Yes Yes Yes CLIK1L VAVK HRD DFG Yes Yes Yes Yes CLK1 VAVK HTD DFG Yes Yes Yes Yes CLK2 VALK HTD DFG Yes Yes Yes Yes CLK3 VALK HTD DFG Yes Yes Yes Yes CLK4 VAVK HTD DFG Yes Yes Yes Yes COT MACK HHD DFG Yes Yes Yes Yes CRIK YAMK HRD DFG Yes Yes Yes Yes CRK7 VALK HRD DFG Yes Yes Yes Yes CSK VAVK HRD DFG Yes Yes Yes Yes CTK VAVK HRD DFG Yes Yes Yes Yes DAPK1 YAAK HFD DFG Yes Yes Yes Yes DAPK2 YAAK HFD DFG Yes Yes Yes Yes DAPK3 YAAK HFD DFG Yes Yes Yes Yes DCAMKL1 YALK HRD DFG Yes Yes Yes Yes DCAMKL2 FALK HRD DFG Yes Yes Yes Yes DCAMKL3 YAMK HRD DFG Yes Yes Yes Yes DDR1 VAVK HRD DFG Yes Yes Yes Yes DDR2 VAVK HRD DFG Yes Yes Yes Yes DLK VAVK HRD DFG Yes Yes Yes Yes DMPK1 YAMK HRD DFG Yes Yes Yes Yes DMPK2 FAMK HRD DFG Yes Yes Yes Yes DNAPK FLVK IGDRH DFG Yes Yes Yes Yes HRD motif modified in PIKKs DRAK2 YAAK HLD DFG Yes Yes Yes Yes DYRK1A VAIK HCD DFG Yes Yes Yes Yes DYRK1B VAIK HCD DFG Yes Yes Yes Yes DYRK2 VALK HCD DFG Yes Yes Yes Yes DYRK3 VALK HCD DFG Yes Yes Yes Yes DYRK4 VALK HCD DFG Yes Yes Yes Yes EGFR VAIK HRD DFG Yes Yes Yes Yes EphA1 VAIK HRD DFG Yes Yes Yes Yes EphA2 VAIK HRD DFG Yes Yes Yes Yes EphA3 VAIK HRD DFG Yes Yes Yes Yes EphA4 VAIK HRD DFG Yes Yes Yes Yes EphA5 VAIK HRD DFG Yes Yes Yes Yes EphA6 VAIK HRD DFG Yes Yes Yes Yes EphA7 VAIK HRD DFG Yes Yes Yes Yes EphA8 VAIK HRD DFG Yes Yes Yes Yes EphB1 VAIK HRD DFG Yes Yes Yes Yes EphB2 VAIK HRD DFG Yes Yes Yes Yes EphB3 VAIK HRD DFG Yes Yes Yes Yes EphB4 VAIK HRD DFG Yes Yes Yes Yes ErbB2 VAIK HRD DFG Yes Yes Yes Yes ErbB4 VAIK HRD DFG Yes Yes Yes Yes ERK1 VAIK HRD DFG Yes Yes Yes Yes ERK2 VAIK HRD DFG Yes Yes Yes Yes ERK3 VAIK HRD DFG Yes Yes Yes Yes ERK4 VAVK HRD DFG Yes Yes Yes Yes ERK5 VAIK HRD DFG Yes Yes Yes Yes ERK7 VAIK HRD DFG Yes Yes Yes Yes FAK VAIK HRD DFG Yes Yes Yes Yes FER VAIK HRD DFG Yes Yes Yes Yes FES VAVK HRD DFG Yes Yes Yes Yes FGFR1 VAVK HRD DFG Yes Yes Yes Yes FGFR2 VAVK HRD DFG Yes Yes Yes Yes FGFR3 VAVK HRD DFG Yes Yes Yes Yes FGFR4 VAVK HRD DFG Yes Yes Yes Yes FGR VAVK HRD DFG Yes Yes Yes Yes FLT1 VAVK HRD DFG Yes Yes Yes Yes FLT3 VAVK HRD DFG Yes Yes Yes Yes FLT4 VAVK HRD DFG Yes Yes Yes Yes FMS VAVK HRD DFG Yes Yes Yes Yes FRAP FLLK LGDRH DFG Yes Yes Yes Yes HRD motif modified in PIKKs FRK VAVK HRD DFG Yes Yes Yes Yes Fused VALK HRD DFG Yes Yes Yes Yes FYN VAIK HRD DFG Yes Yes Yes Yes GAK YALK HRD DFG Yes Yes Yes Yes GCK AAVK HRD DFG Yes Yes Yes Yes GCN2 YAVK HRD DFG Yes Yes Yes Yes GPRK4 YACK YRD DLG Yes Yes Yes Yes GPRK5 YACK YRD DLG Yes Yes Yes Yes GPRK6 YACK YRD DLG Yes Yes Yes Yes GSK3A VAIK HRD DFG Yes Yes Yes Yes GSK3B VAIK HRD DFG Yes Yes Yes Yes HCK VAVK HRD DFG Yes Yes Yes Yes HH498 VAIK HRD DFG Yes Yes Yes Yes HIPK1 VAIK HAD DFG Yes Yes Yes Yes HIPK2 VAIK HAD DFG Yes Yes Yes Yes HIPK3 VAIK HAD DFG Yes Yes Yes Yes HIPK4 VAIK HAD DFG Yes Yes Yes Yes HPK1 VALK HRD DFG Yes Yes Yes Yes HRI YAIK HRD DFG Yes Yes Yes Yes HUNK VAIK HRD DFG Yes Yes Yes Yes ICK IAIK HRD DFG Yes Yes Yes Yes IGF1R VAIK HRD DFG Yes Yes Yes Yes IKKa IAIK HRD DLG Yes Yes Yes Yes IKKb IAIK HRD DLG Yes Yes Yes Yes IKKe VAVK HRD DFG Yes Yes Yes Yes INSR VAVK HRD DFG Yes Yes Yes Yes IRAK1 YAVK HGD DFG Yes Yes Yes Yes IRAK4 VAVK HRD DFG Yes Yes Yes Yes IRE1 VAVK HRD DFG Yes Yes Yes Yes IRE2 VAVK HRD DFG Yes Yes Yes Yes IRR VALK HRD DFG Yes Yes Yes Yes ITK VAIK HRD DFG Yes Yes Yes Yes JAK1 VAVK HRD DFG Yes Yes Yes Yes JAK2 VAVK HRD DFG Yes Yes Yes Yes JAK3 VAVK HRD DFG Yes Yes Yes Yes JNK1 VAIK HRD DFG Yes Yes Yes Yes JNK2 VAVK HRD DFG Yes Yes Yes Yes JNK3 VAIK HRD DFG Yes Yes Yes Yes KDR VAVK HRD DFG Yes Yes Yes Yes KHS1 AAVK HRD DFG Yes Yes Yes Yes KHS2 AAIK HRD DFG Yes Yes Yes Yes KIS GALK HAD DFG Yes Yes Yes Yes KIT VAVK HRD DFG Yes Yes Yes Yes LATS1 YATK HRD DFG Yes Yes Yes Yes LATS2 YAMK HRD DFG Yes Yes Yes Yes LCK VAVK HRD DFG Yes Yes Yes Yes LIMK1 MVMK HRD DFG Yes Yes Yes Yes LIMK2 MVMK HRD DFG Yes Yes Yes Yes LKB1 RAVK HKD DLG Yes Yes Yes Yes LMR1 VVVK HSD DYG Yes Yes Yes Yes LMR2 VIVK HSD DYG Yes Yes Yes Yes LMR3 VVVK HSD DYG Yes Yes Yes Yes LOK AAAK HRD DFG Yes Yes Yes Yes LRRK1 VAVK FCD DYG Yes Yes Yes Yes LRRK2 VAVK YRD DYG Yes Yes Yes Yes LTK VAIK HRD DFG Yes Yes Yes Yes LYN VAVK HRD DFG Yes Yes Yes Yes LZK VAIK HRD DFG Yes Yes Yes Yes MAK VAIK HRD DFG Yes Yes Yes Yes MAP2K1 MARK HRD DFG Yes Yes Yes Yes MAP2K2 MARK HRD DFG Yes Yes Yes Yes MAP2K3 MAVK HRD DFG Yes Yes Yes Yes MAP2K4 MAVK HRD DFG Yes Yes Yes Yes MAP2K5 LAVK HRD DFG Yes Yes Yes Yes MAP2K6 MAVK HRD DFG Yes Yes Yes Yes MAP2K7 IAVK HRD DFG Yes Yes Yes Yes MAP3K1 MAVK HRD DFG Yes Yes Yes Yes MAP3K2 LAVK HRD DFG Yes Yes Yes Yes MAP3K3 LASK HRD DFG Yes Yes Yes Yes MAP3K4 MAMK HRD DFG Yes Yes Yes Yes MAP3K5 IAIK HRD DFG Yes Yes Yes Yes MAP3K6 IAIK HRD DFG Yes Yes Yes Yes MAP3K7 IAIK HRD DFG Yes Yes Yes Yes MAP3K8 IAVK HRD DFG Yes Yes Yes Yes MAPKAPK2 FALK HRD DFG Yes Yes Yes Yes MAPKAPK3 CALK HRD DFG Yes Yes Yes Yes MAPKAPK5 FALK HRD DFG Yes Yes Yes Yes MARK1 VAVK HRD DFG Yes Yes Yes Yes MARK2 VAVK HRD DFG Yes Yes Yes Yes MARK3 VAIK HRD DFG Yes Yes Yes Yes MARK4 VAIK HRD DFG Yes Yes Yes Yes MarkmA1 VAVK HRD DFG Yes Yes Yes Yes MarkmA11 VAVK HRD DFG Yes Yes Yes Yes MarkmA12 VAIK HRD DFG Yes Yes Yes Yes MarkmA2 VAIK HRD DFG Yes Yes Yes Yes MarkmA3 VAVK HRD DFG Yes Yes Yes Yes MarkmA4 VAVK HRD DFG Yes Yes Yes Yes MarkmA5 VAVK HRD DFG Yes Yes Yes Yes MarkmA6 VAIK HRD DFG Yes Yes Yes Yes MarkmA7 VAVK HRD DFG Yes Yes Yes Yes MarkmA8 VAVK HRD DFG Yes Yes Yes Yes MarkmA9 VAVK HRD DFG Yes Yes Yes Yes MarkmB1 VAIK HQD DFG Yes Yes Yes Yes MarkmB1rs VAIK HQD DFG Yes Yes Yes Yes MarkmB2 VAVK HRD DFG Yes Yes Yes Yes MarkmB3 VAIK HGD DFG Yes Yes Yes Yes MarkmC1 VAVK HRD DFG Yes Yes Yes Yes MarkmC2 VAVK HRD DFG Yes Yes Yes Yes MarkmD1 VALK HRD DFG Yes Yes Yes Yes MarkmD2 VAVK HRD DFG Yes Yes Yes Yes MarkmD4 VAVK HRD DFG Yes Yes Yes Yes MarkmE1 VAIK HRD DFG Yes Yes Yes Yes MarkmE2 VAIK HRD DFG Yes Yes Yes Yes MAST1 FAMK HRD DFG Yes Yes Yes Yes MAST2 FAMK HRD DFG Yes Yes Yes Yes MAST3 FAIK HRD DFG Yes Yes Yes Yes MAST4 FAMK HRD DFG Yes Yes Yes Yes MASTL YAVK HRD DFG Yes Yes Yes Yes MELK VAIK HRD DFG Yes Yes Yes Yes MER VAVK HRD DFG Yes Yes Yes Yes MET CAVK HRD DFG Yes Yes Yes Yes MISR2 VAIK HRD DLG Yes Yes Yes Yes MLK1 VAVK HRD DFG Yes Yes Yes Yes MLK2 VAVK HRD DFG Yes Yes Yes Yes MLK3 VAVK HRD DFG Yes Yes Yes Yes MLK4 VAVK HRD DFG Yes Yes Yes Yes MNK1 YAVK HRD DFD Yes Yes Yes Yes MNK2 YAVK HRD DFD Yes Yes Yes Yes MOK YACK HRD DFG Yes Yes Yes Yes MOS VAIK HLD DFG Yes Yes Yes Yes MPSK1 YALK HRD DLG Yes Yes Yes Yes MRCKa FAMK HRD DFG Yes Yes Yes Yes MRCKb YAMK HRD DFG Yes Yes Yes Yes MSK1 YAMK YRD DFG Yes Yes Yes Yes MSK2 YAMK YRD DFG Yes Yes Yes Yes MSSK1 VALK HTD DLG Yes Yes Yes Yes MST1 VAIK HRD DFG Yes Yes Yes Yes MST2 VAIK HRD DFG Yes Yes Yes Yes MST3 VAIK HRD DFG Yes Yes Yes Yes MST4 VAIK HRD DFG Yes Yes Yes Yes MUSK VAVK HRD DFG Yes Yes Yes Yes MYO3A AAVK HRD DFG Yes Yes Yes Yes MYO3B AAVK HRD DFG Yes Yes Yes Yes MYT1 YAVK HLD DFG Yes Yes Yes Yes NDR1 YAMK HRD DFG Yes Yes Yes Yes NDR2 YAMK HRD DFG Yes Yes Yes Yes NEK1 YVIK HRD DFG Yes Yes Yes Yes NEK10 LAMK HRD DFG Yes Yes Yes Yes NEK11 KVLK HRD DFG Yes Yes Yes Yes NEK2 LVWK HRD DFG Yes Yes Yes Yes NEK3 FAMK HRD DFG Yes Yes Yes Yes NEK4 YVIK HRD DLG Yes Yes Yes Yes NEK5 CVIK HRD DFG Yes Yes Yes Yes NEK6 VALK HRD DLG Yes Yes Yes Yes NEK7 VALK HRD DLG Yes Yes Yes Yes NEK8 VILK HRD DFG Yes Yes Yes Yes NEK9 VVWK HRD DYG Yes Yes Yes Yes NIK CAVK HGD DFG Yes Yes Yes Yes NIM1 VAIK HRD DFG Yes Yes Yes Yes NLK VALK HRD DFG Yes Yes Yes Yes NuaK1 VAIK HRD DFG Yes Yes Yes Yes NuaK2 VAIK HRD DFG Yes Yes Yes Yes Obscn CAAK HLD DFG Yes Yes Yes Yes OSR1 VAIK HRD DFG Yes Yes Yes Yes p38a VAVK HRD DFG Yes Yes Yes Yes p38b VAVK HRD DFG Yes Yes Yes Yes p38d VAIK HRD DFG Yes Yes Yes Yes p38g VAIK HRD DFG Yes Yes Yes Yes p70S6K FAMK YRD DFG Yes Yes Yes Yes p70S6Kb YAMK YRD DFG Yes Yes Yes Yes PAK1 VAIK HRD DFG Yes Yes Yes Yes PAK2 VAIK HRD DFG Yes Yes Yes Yes PAK3 VAIK HRD DFG Yes Yes Yes Yes PAK4 VAVK HRD DFG Yes Yes Yes Yes PAK5 VAVK HRD DFG Yes Yes Yes Yes PAK6 VAVK HRD DFG Yes Yes Yes Yes PASK VVVK HRD DFG Yes Yes Yes Yes PBK WAVK HGD DVG Yes Yes Yes Yes PCTAIRE1 VALK HRD DFG Yes Yes Yes Yes PCTAIRE2 VALK HRD DFG Yes Yes Yes Yes PCTAIRE3 VALK HRD DFG Yes Yes Yes Yes PDGFRa VAVK HRD DFG Yes Yes Yes Yes PDGFRb VAVK HRD DFG Yes Yes Yes Yes PDK1 YAIK HRD DFG Yes Yes Yes Yes PEK YAIK HRD DFG Yes Yes Yes Yes PFTAIRE1 VALK HRD DFG Yes Yes Yes Yes PFTAIRE2 VALK HRD DFG Yes Yes Yes Yes PHKg1 YAVK HRD DFG Yes Yes Yes Yes PHKg2 FAVK HRD DFG Yes Yes Yes Yes PIK3R4 VVVK HGD DFA Yes Yes Yes Yes PIM1 VAIK HRD DFG Yes Yes Yes Yes PIM2 VAIK HRD DFG Yes Yes Yes Yes PIM3 VAVK HRD DFG Yes Yes Yes Yes PINK1 FAIK HRD DFG Yes Yes Yes Yes PITSLRE VALK HRD DFG Yes Yes Yes Yes PKACa YAMK YRD DFG Yes Yes Yes Yes PKACb YAMK YRD DFG Yes Yes Yes Yes PKCa YAIK YRD DFG Yes Yes Yes Yes PKCb YAVK YRD DFG Yes Yes Yes Yes PKCd FAIK YRD DFG Yes Yes Yes Yes PKCeps YAVK YRD DFG Yes Yes Yes Yes PKCeta YAVK YRD DFG Yes Yes Yes Yes PKCg YAIK YRD DFG Yes Yes Yes Yes PKCi YAMK YRD DYG Yes Yes Yes Yes PKCt FAIK YRD DFG Yes Yes Yes Yes PKCz YAMK YRD DYG Yes Yes Yes Yes PKD1 VAIK HCD DFG Yes Yes Yes Yes PKD2 VAVK HCD DFG Yes Yes Yes Yes PKD3 VAIK HCD DFG Yes Yes Yes Yes PKG1 FAMK YRD DFG Yes Yes Yes Yes PKG2 FAMK YRD DFG Yes Yes Yes Yes PKN1 FAIK YRD DFG Yes Yes Yes Yes PKN2 FAIK YRD DFG Yes Yes Yes Yes PKN3 YAIK YRD DFG Yes Yes Yes Yes PKR YAIK HRD DFG Yes Yes Yes Yes PLK1 FAGK HRD DFG Yes Yes Yes Yes PLK2 YAAK HRD DFG Yes Yes Yes Yes PLK3 YAVK HRD DFG Yes Yes Yes Yes PLK4 VAIK HRD DFG Yes Yes Yes Yes PLK5 FALK HRD DLG Yes Yes Yes Yes PRKX CALK YRD DFG Yes Yes Yes Yes PRP4 VAVK HAD DFG Yes Yes Yes Yes PRPK VVKH HGD DFG No Yes Yes Yes Alternative K nearby is conserved in several orthologs (from human analysis) PSKH1 YAIK HRD DFG Yes Yes Yes Yes PYK2 VAVK HRD DFG Yes Yes Yes Yes QIK VAIK HRD DFG Yes Yes Yes Yes QSK VAIK HRD DFG Yes Yes Yes Yes RAF1 VAVK HRD DFG Yes Yes Yes Yes RET VAVK HRD DFG Yes Yes Yes Yes RHOK YACK YRD DLG Yes Yes Yes Yes RIPK1 ILKK HKD DLG Yes Yes Yes Yes RIPK2 VAVK HHD DFG Yes Yes Yes Yes RIPK3 VAVK HRD DFG Yes Yes Yes Yes RNAseL VAVK HQD DFD Yes Yes Yes Yes ROCK1 YAMK HRD DFG Yes Yes Yes Yes ROCK2 YAMK HRD DFG Yes Yes Yes Yes RON CAIK HRD DFG Yes Yes Yes Yes ROR1 VAIK HKD DLG Yes Yes Yes Yes ROR2 VAIK HKD DLG Yes Yes Yes Yes ROS VAVK HRD DFG Yes Yes Yes Yes RSK1 YAMK YRD DFG Yes Yes Yes Yes RSK2 YAMK YRD DFG Yes Yes Yes Yes RSK3 YAMK YRD DFG Yes Yes Yes Yes RSK4 YAMK YRD DFG Yes Yes Yes Yes RYK TFVK HRD DNA Yes Yes Yes Yes SBK MALK HRD DFG Yes Yes Yes Yes SGK YAVK YRD DFG Yes Yes Yes Yes SgK069 LALK YRD DFG Yes Yes Yes Yes SgK085 LAAK HLD DFG Yes Yes Yes Yes SgK110 VALK HAD DLG Yes Yes Yes Yes SGK2 YAVK YRD DFG Yes Yes Yes Yes SgK288 YAIK HLD DFG Yes Yes Yes Yes SGK3 YAVK YRD DFG Yes Yes Yes Yes SgK493 VALK LLD DLD Yes Yes Yes Yes SgK494 FAVK HRD DFG Yes Yes Yes Yes SgK496 CALK HRD DLG Yes Yes Yes Yes SIK VAIK HRD DFG Yes Yes Yes Yes skMLCK LAAK HLD DFG Yes Yes Yes Yes SLK AAAK HRD DFG Yes Yes Yes Yes SMG1 YLFK LGDRH DYN Yes Yes Yes Yes HRD motif modified in PIKKs smMLCK WAGK HLD DFG Yes Yes Yes Yes SNRK VAVK HRD DFG Yes Yes Yes Yes SPEG FAAK HLD DFG Yes Yes Yes Yes SRC VAIK HRD DFG Yes Yes Yes Yes SRM VAVK HRD DFG Yes Yes Yes Yes SRPK1 VAMK HTD DLG Yes Yes Yes Yes SRPK2 VAMK HTD DLG Yes Yes Yes Yes SSTK VAIK HRD DFG Yes Yes Yes Yes STK33 WAIK HRD DFG Yes Yes Yes Yes STLK3 VAIK HRD DFG Yes Yes Yes Yes SYK VAVK HRD DFG Yes Yes Yes Yes TAK1 VAIK HRD DFG Yes Yes Yes Yes TAO1 VAIK HRD DFG Yes Yes Yes Yes TAO2 VAIK HRD DFG Yes Yes Yes Yes TAO3 VAVK HRD DFG Yes Yes Yes Yes TBK1 YAVK HRD DFG Yes Yes Yes Yes TEC VAIK HRD DFG Yes Yes Yes Yes TESK1 MALK HRD DFG Yes Yes Yes Yes TESK2 MALK HRD DFG Yes Yes Yes Yes TGFBR1 VAVK HRD DLG Yes Yes Yes Yes TGFBR2 VAVK HRD DFG Yes Yes Yes Yes TIE1 AAIK HRD DFG Yes Yes Yes Yes TIE2 AAIK HRD DFG Yes Yes Yes Yes TLK1 AAVK HYD DFG Yes Yes Yes Yes TLK2 VAVK HYD DFG Yes Yes Yes Yes TNK1 VAVK HRD DFG Yes Yes Yes Yes Trad VAVK HLD DLE Yes Yes Yes Yes Trio VATK HLD DFG Yes Yes Yes Yes TRKA VAVK HRD DFG Yes Yes Yes Yes TRKB VAVK HRD DFG Yes Yes Yes Yes TRKC VAVK HRD DFA Yes Yes Yes Yes TSSK1 VAVK HRD DFG Yes Yes Yes Yes TSSK2 VAVK HRD DFG Yes Yes Yes Yes TSSK3 VAIK HRD DFG Yes Yes Yes Yes TSSK4 VAVK HRD DFG Yes Yes Yes Yes TSSK5 VAIK HRD DFG Yes Yes Yes Yes TTBK1 VALK HRD DFG Yes Yes Yes Yes TTBK2 VALK HRD DFG Yes Yes Yes Yes TTK NAIK HSD DFG Yes Yes Yes Yes TXK VAIK HRD DFG Yes Yes Yes Yes TYK2 VAVK HRD DFG Yes Yes Yes Yes TYRO3 VAVK HRD DFG Yes Yes Yes Yes ULK1 VAVK HRD DFG Yes Yes Yes Yes ULK2 VAIK HRD DFG Yes Yes Yes Yes ULK3 VAIK HLD DFG Yes Yes Yes Yes VRK1 CVVK HGD DYG Yes Yes Yes Yes VRK2 HVIK HGD DYG Yes Yes Yes Yes Wee1 YAIK HMD DLG Yes Yes Yes Yes Wee1B YAIK HLD DLG Yes Yes Yes Yes Wnk1 VAWC HRD DLG No Yes Yes Yes Alternative K used by Wnks Wnk2 VAWC HRD DLG No Yes Yes Yes Alternative K used by Wnks Wnk3 VAWC HRD DLG No Yes Yes Yes Alternative K used by Wnks Wnk4 VAWC HRD DLG No Yes Yes Yes Alternative K used by Wnks YANK1 YAMK HRD DFN Yes Yes Yes Yes YANK2 YAMK HRD DFN Yes Yes Yes Yes YANK3 YAMK HRD DFN Yes Yes Yes Yes YES VAIK HRD DFG Yes Yes Yes Yes YSK1 VAIK HRD DFG Yes Yes Yes Yes ZAK VAVK HRD DFG Yes Yes Yes Yes ZAP70 VAIK HRD DFG Yes Yes Yes Yes ZC1 AAIK HRD DFG Yes Yes Yes Yes ZC2 AAIK HRD DFG Yes Yes Yes Yes ZC3 AAIK HRD DFG Yes Yes Yes Yes ZC4 VAVK HRD DFG Yes Yes Yes Yes zMSK1 FAVK HRD DFG Yes Yes Yes Yes zMSK2 FAVK HRD DFG Yes Yes Yes Yes zObscn LAAK HLD DLG Yes Yes Yes Yes zRSK1 YAVK HRD DFG Yes Yes Yes Yes zRSK2 FAVK HRD DFG Yes Yes Yes Yes zRSK3 YAVK HRD DFG Yes Yes Yes Yes zRSK4 FAVK HRD DFG Yes Yes Yes Yes zSPEG FVAK HLD DFG Yes Yes Yes Yes