Gene IRAK-0_bf (S.moellendorffii)

IRAK-0_bf

Species: S.moellendorffii
Alias: IRAK-0_bf
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-0

Sequence

Name Sequence Type Origin Length Description Download
IRAK-0_bf.AA Protein None 691 None Fasta, JSON
IRAK-0_bf.NA RNA None 2087 None Fasta, JSON
IRAK-0_bf.kin_dom Protein Kinase Domain None 82 None Fasta, JSON

Protein domain

Protein domains of IRAK-0_bf.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAK-0_bf.AA B_lectin 241-292 46 4.4e-15 53.41 Pfam 45-109 (137) Show / Hide 
Range on Protein: 241-292
Range on HMM: 45-109/137
Sequence Identity: 46% (30 aa)

G-SF--VWLT--NTGGSGA-Q--VLALESSGNLVIR-SKI--GAFLWQS--FDHPCDAVLPGMKL
| |   || |  || |||.    .. .  |||||.. ..   ...||||  |||| | .||||||
GGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPTDTWLPGMKL
B_lectin IRAK-0_bf.AA B_lectin 159-282 24 1e-05 14.13 SMART 1-126 (126) Show / Hide 
Range on Protein: 159-282
Range on HMM: 1-126/126
Sequence Identity: 24% (33 aa)

RQVALNKSSFNSIHKIVRWFSLDNANRNPQPSQAQAGYLSTSLS--TRSPSLEA--GRGAEAKA--NSKYLEWIREWSLEEDGAS--SDIGSFVWLTNTG
... ..  .  | ...     . . . .....    | .  . |  .| .   |  .|.  ..   || ||      .. .||     | .. || .||.
DNTLSSGQTLVSGNSLFE---FYLGFFTFIMQ-WCNGIWYKNISNKQRTVVWVAQPNRDNPVHDGNNSCYL------TMQSDGNLVIYD-NRPVWSSNTT

-GSGAQVLALESSGNLVIRSKI----GAFLWQSFDHP
 ..|  |. |  .||.||..      | |.|||||||
RNNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
Kinase IRAK-0_bf.AA TKL 534-677 18 3.8e-30 105.74 In-house 1-290 (364) Show / Hide 
Range on Protein: 534-677
Range on HMM: 1-290/364
Sequence Identity: 18% (54 aa)

IASGGVGTVFEGILS-------------VAVKRLESFSSQGYKQ-------------------------FKAEESH------------------------
| ||| |.|. |..              ||||.. | ...                             |. ||                          
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------YFLIYEYVANGSLDKWIYKPREELNWDTRFKIVEEIARGMCYLHEECS-----TRVLHLDIKPQNLLLDENFG--------------V
            .....||. .|||   .        |. |.... .|||||.||| .         ..| |.|..|.|.|||.               .
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH-------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCC

KIAEFGLSRMM-----------------------------R---------VRDKL----------------------DIYSFGILVLEVASGLQAFH
||. |||||.|                             .         | ..                       |.|||||.  |.... . ..
KICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYY
Kinase IRAK-0_bf.AA TKL-Unique 569-649 30 8.9e-23 77.26 In-house 72-165 (290) Show / Hide 
Range on Protein: 569-649
Range on HMM: 72-165/290
Sequence Identity: 30% (29 aa)

ESHYFLIYEYVANGSLDKWIY---------KPREELNWDTRFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDEN-----FGVKIAEFGLSR
....... ||.  |||.. .          ..  .||.  | |... ||.||.||| .  . ..|.|.|..|.|.|.|     . .||. ||||.
PPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSK
Kinase IRAK-0_bf.AA RIPK 577-652 41 1.8e-19 63.0 In-house 82-160 (290) Show / Hide 
Range on Protein: 577-652
Range on HMM: 82-160/290
Sequence Identity: 41% (34 aa)

EYVANGSLDKWIYKPREE----LNWDTRFKIVEEIARGMCYLHEECSTR--VLHLDIKPQNLLLDENFGVKIAEFGLSRMMR
|| .|||| .      .     . |. |. .. ||..||||||   |    ..|.| ||.| |.| || |||| |||.  |.
EYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLH---SMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMM
Kinase IRAK-0_bf.AA Dicty4 577-652 32 1.2e-18 58.97 In-house 82-165 (277) Show / Hide 
Range on Protein: 577-652
Range on HMM: 82-165/277
Sequence Identity: 32% (28 aa)

EYVANGSLDKWIYK------PREELNWDTRFK---IVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDENFGVKIAEFGLSRMMR
||.  |.| . . .      .. .| | .. .   .   .|||| .||. | ....|.|.|. ||| |.|. ||.. ||||..|.
EYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMK
Kinase IRAK-0_bf.AA Pkinase 568-651 25 1.5e-17 63.12 Pfam 71-162 (293) Show / Hide 
Range on Protein: 568-651
Range on HMM: 71-162/293
Sequence Identity: 25% (24 aa)

EESHYFLIYEYVANG----SLDKWIY-KPREEL--NWDTRFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDENFGV----KIAEFGLSRMM
...|. .. ||. .|    .|  .|  . .  .   ...  ... .|.||. |.|..   ...| |.||.|.|.|.|  .    ||. |||.. .
DKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQF
Kinase IRAK-0_bf.AA DRK 577-648 40 4.3e-15 47.6 In-house 77-147 (258) Show / Hide 
Range on Protein: 577-648
Range on HMM: 77-147/258
Sequence Identity: 40% (29 aa)

EYVANGSLDKWIYKPREELNWDTRFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDENFGVKIAEFGLS
||   ||| .    .  |. |  . ..   .|.|| |||  |   ..| | |  ||| ||.. ||.| ||||
EYMPRGSLYNILHDESIEMDWPLMKQMMFDCAKGMIYLH-CCNPIIIHRDLKSHNLLVDEHWQVKVADFGLS
Kinase IRAK-0_bf.AA Ciliate-E2 562-649 24 2.2e-14 45.8 In-house 98-204 (365) Show / Hide 
Range on Protein: 562-649
Range on HMM: 98-204/365
Sequence Identity: 24% (28 aa)

YKQFKA-EESHYFLIYEYVANGSLDKWIY----KPREELN------WDTRFKIVEEIAR---------------GMCYLHEECSTRVLHLDIKPQNLLLD
|  |.   .....|. ||.  |.| ..|.    |  .|..      .  . .| ..|..               .. |||.. .  ..| ||||.|.|. 
YECFQEKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRDIKPENILF-

ENFGVKIAEFGLSR
    .||. ||||.
----IKIIDFGLSK
Kinase IRAK-0_bf.AA MLK 568-651 27 7.7e-14 44.5 In-house 81-183 (291) Show / Hide 
Range on Protein: 568-651
Range on HMM: 81-183/291
Sequence Identity: 27% (28 aa)

EESHYFLIYEYVANGSLDKWIYKPREELN-------------WDTRFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDE------NFGVKIAEFGLS
...|.... ||...|||   ..  | . .              |  ...   .|||| |||..    . | |.|..|.|.||      .  .||. ||.|
PPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTS

RMM
|..
RDW
Kinase IRAK-0_bf.AA LISK 568-651 31 5e-13 38.47 In-house 68-155 (296) Show / Hide 
Range on Protein: 568-651
Range on HMM: 68-155/296
Sequence Identity: 31% (29 aa)

EESHYFLIYEYVANGSLDKWIYKPRE---ELNWDTRFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDEN----FGVKIAEFGLSRMM
........ ||.  | |   . .. .    | |. | ||   ||.|| |||. .   ..| | | .|.|..||    . .|.. ||. |||
NDGQLHIVTEYINGGDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMM
Kinase IRAK-0_bf.AA IRAK 567-649 37 6.5e-13 42.26 In-house 73-161 (317) Show / Hide 
Range on Protein: 567-649
Range on HMM: 73-161/317
Sequence Identity: 37% (33 aa)

AEESHYFLIYEYVANGSLDK--WIYKPREE---LNWDTRFKIVEEIARGMCYLHEEC-STRVLHLDIKPQNLLLDENFGVKIAEFGLSR
.|.. . |.|.| .||||    |  ..      | | .|..| . .|.|  .||.    | . | |||. | |||..|  ||. ||| |
TERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHR
Kinase IRAK-0_bf.AA Dicty5 572-649 33 2.3e-12 38.87 In-house 73-152 (260) Show / Hide 
Range on Protein: 572-649
Range on HMM: 73-152/260
Sequence Identity: 33% (28 aa)

Y-FLIYEYVANGSLDKWIYKPRE----ELNWDTRFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDENFGVKIAEFGLSR
| | . ||. ||||       |      . . ..  .   ||..| .||   |  . | |.|  | |. ||. .||  || ||
YPFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLH---SMNIIHRDLKSMNFLITENWKIKIIDFGTSR
S_TKc IRAK-0_bf.AA S_TKc 528-688 17 9.6e-09 -48.67 SMART 1-231 (231) Show / Hide 
Range on Protein: 528-688
Range on HMM: 1-231/231
Sequence Identity: 17% (43 aa)

KAFSEKIASGGVGTVFEGILSV-----AVKRLESFSSQGYKQFKAE------------------E-SHYFLIYEYVAN--GSLDKWIYKPREE-----LN
  . .|| .|. |.|. ..        |.|..        .... |                  . .|.... ||. .  |.| . | | . .     ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKKHHPNIVKLYDVFQDDHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFP

WDTRFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDENFGVKIAEFGLSRMM---------------RVRD-KLDIYSFGILVLEVASGLQAFH---
  .  ... .|.... |.|.     ..| |.||.|.||||   .||. |||.| .                    | |..|.|... | ..|   |.   
E-HARFYMYQICCALEYCHSHG---IIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFPQMQ

---------------------------TCVSCGR-------SPKF
                           |.  . .        | |
MMFKKIGSPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-0_bf.AA Pkinase_Tyr 568-659 25 1.4e-08 29.72 Pfam 76-176 (270) Show / Hide 
Range on Protein: 568-659
Range on HMM: 76-176/270
Sequence Identity: 25% (27 aa)

EESH--YFLIYEYVANGSLDKWIYKP---REELNWDTRFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDENFGVKIAEFGLSRMM-------RVRD
.. .  .... ||...|.|..   |.   .. |.  .  ..  .||.|| ||..       | |.   | |..||. |||. |||.| .       |.|.
QGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRG

KLDI
. ..
GGKL
TyrKc IRAK-0_bf.AA TyrKc 528-691 17 2e-08 -86.3 SMART 1-280 (280) Show / Hide 
Range on Protein: 528-691
Range on HMM: 1-280/280
Sequence Identity: 17% (49 aa)

KAFSEKIASGGVGTVFEGILS--VAVKRLESFSSQGYKQFKAE-----------------------E-------SHYFLIYEYVANGSLDKWIYKPREEL
  . .|. .|  |.|..|...  |||| | . .    . |  |                       .         .... ||...|.|.. . |.|..|
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKL

NWDTRFKIVEEIARGMCYLHEECSTRVLHLDIKPQNLLLDENFGVKIAEFGLSRMMRVR-----------------DK------------L---------
....  ..   ||.|| |||.    .. | |.   | |..||. |||. |||||                       |            .         
CMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DIYSFGILVLEV---------------ASGLQAFHTCVSCGRSPKFLA-------------------------------------V
|..|||..  |.                |  ....   . .| |.                                         
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-0_bf.AA IRAK 656-675 52 1.6e-05 15.74 In-house 204-224 (317) Show / Hide 
Range on Protein: 656-675
Range on HMM: 204-224/317
Sequence Identity: 52% (11 aa)

KLDIYSFGILVLEVASGL-QA
|.|.||||| .|||..|. ..
KTDVYSFGIVLLEVLTGCRAV
Kinase IRAK-0_bf.AA TKL-Unique 530-555 37 0.002311 7.93 In-house 1-29 (290) Show / Hide 
Range on Protein: 530-555
Range on HMM: 1-29/290
Sequence Identity: 37% (11 aa)

FSEKIASGGVGTVFEGIL---SVAVKRLE
|..|| .||.|.|. |.    .||.|...
FWNKIGEGGYGQVYKGKWRGYPVAIKQFH
Kinase IRAK-0_bf.AA Dicty5 529-546 50 0.009274 5.32 In-house 2-19 (260) Show / Hide 
Range on Protein: 529-546
Range on HMM: 2-19/260
Sequence Identity: 50% (9 aa)

AFSEKIASGGVGTVFEGI
.| . ||||  |.|. ||
SFHDWIASGASGRVYNGI
Kinase IRAK-0_bf.AA LISK 655-668 42 0.019754 3.48 In-house 218-231 (296) Show / Hide 
Range on Protein: 655-668
Range on HMM: 218-231/296
Sequence Identity: 42% (6 aa)

DKLDIYSFGILVLE
.. |..||||...|
ESCDVFSFGIVLCE
Kinase IRAK-0_bf.AA RIPK 653-676 37 0.139656 1.12 In-house 205-228 (290) Show / Hide 
Range on Protein: 653-676
Range on HMM: 205-228/290
Sequence Identity: 37% (9 aa)

VRDKLDIYSFGILVLEVASGLQAF
|  | |.|||.|.. || .. ...
VTPKYDVYSFAIVMWEVLTQKHPY