Gene IRAK-14_e (S.moellendorffii)

IRAK-14_e

Species: S.moellendorffii
Alias: IRAK-14_e
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-14

Sequence

Name Sequence Type Origin Length Description Download
IRAK-14_e.AA Protein None 893 None Fasta, JSON
IRAK-14_e.NA RNA None 2682 None Fasta, JSON
IRAK-14_e.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of IRAK-14_e.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Malectin IRAK-14_e.AA Malectin 53-69 30 12.257562 0.97 Pfam 1-20 (202) Show / Hide 
Range on Protein: 53-69
Range on HMM: 1-20/202
Sequence Identity: 30% (6 aa)

DVFRISCGESRS---DIDGN
 ...| || ..    |.||.
YSWHINCGGPEHYTTDSDGI
Malectin IRAK-14_e.AA Malectin 330-384 25 1e-07 31.96 Pfam 107-168 (202) Show / Hide 
Range on Protein: 330-384
Range on HMM: 107-168/202
Sequence Identity: 25% (16 aa)

VRLHFAELVYSS-------PMQRIFSVYINNRTAIRALDLIQQTGAANTPYYRDFLVLPVDG
|.|||||. ..        | .|.| |||.  . .. .|  .. |........ |   .|..
VILHFAEIYFQDTDQTWNSPGRRVFDVYIQGKLVLKDFDIWKEAGGKGKAAHKEFINVTVTN
Kinase IRAK-14_e.AA IRAK 546-740 37 2.7e-64 219.89 In-house 1-217 (317) Show / Hide 
Range on Protein: 546-740
Range on HMM: 1-217/317
Sequence Identity: 37% (81 aa)

FDETRLLGVGGFGRVYKGEIDNGTLEVAVK----RGNPRSEQGIAEFQA---EIGLLSKLRHRHLVSLIGYCDEQSEMILVYEYMARGPLRGHLYGTEDL
|.. ...| |||| ||.|...| |  .|||      ..  ..   .||.   |. .....|| ..|.| ||| | ..  |||.||. | |.  | ..   
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

QP---LPWRHRLEILVGAARGLHYLHTGA---AIIHRDVKTTNILLDEHLVAKVSDFGLSKTG----PMLDQTH---VSTAVKGSFGYLDPEYFR--RQQ
 |   |.|  |..|. |.|.|...||.     .|||.|.|. |||||.|...| .||||   |     ...||        |.|.  |. ||. |    |
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTDKSDVYSFGVVMVEV
|| |.||||||.|  ||
LTKKTDVYSFGIVLLEV
Kinase IRAK-14_e.AA TKL 552-742 22 4.7e-55 189.22 In-house 1-284 (364) Show / Hide 
Range on Protein: 552-742
Range on HMM: 1-284/364
Sequence Identity: 22% (67 aa)

LGVGGFGRVYKGEIDNGT--------LEVAVKRGNPRSEQGIAE-------------------------FQAEIGLLSKLR--HRHLVSLIGYCDEQSE-
.| |||| ||||.  . .         .||||. . ....   .                         |. |  .....|  | ..|...||| . .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------MILVYEYMARGPLRGHLYGTEDLQPLPWRHRLEILVGAARGLHYLHT-------GAAIIHRDVKTTNILLDEHLV-------------
            . .|.||. .| |. .|          | .|. .  ..|||..|||.         .||||| |. |||.||..              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADW

-AKVSDFGLSK-TGPMLDQTHVSTA----------------VKGSFGYLDPEYFRRQ----------------QLTDKSDVYSFGVVMVEVMC
 .|..|||||.   .. .... .|.                . |..... || .| |                . . |.||||||.|. |...
CCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILT
Kinase IRAK-14_e.AA TKL-Unique 549-737 30 3.8e-43 149.65 In-house 2-218 (290) Show / Hide 
Range on Protein: 549-737
Range on HMM: 2-218/290
Sequence Identity: 30% (68 aa)

TRLLGVGGFGRVYKGEIDNG-TLEVAVKRGNPRSEQG---IAEFQAEIGLLSKLR-HRHLVSLIGYCD----EQSEMILVYEYMARGPLRGHLY------
  ..| ||.|.||||.   . . .||.|. .| ...    . ||  |. ...||. |  .| ..|||      ...|..| ||. .| |. .|       
WNKIGEGGYGQVYKGK---WRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNN

-GTEDLQPLPWRHRLEILVGAARGLHYLHTGAA-IIHRDVKTTNILLDEH-----LVAKVSDFGLSKTGPMLDQTHVS-------TAVKGSFGYLDPEYF
   ..  .|..  |. .   .|.|..|||.  . ||||| |..|.|.|..     . .|..||||||.    ... ..       . ..||| .. || .
NNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPPIIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

RR--QQLTDKSDVYSFGVVM
|.   | . ||||||||.|.
RMNFCQYSEKSDVYSFGIVL
Kinase IRAK-14_e.AA Pkinase_Tyr 546-741 32 3.7e-39 133.24 Pfam 1-208 (270) Show / Hide 
Range on Protein: 546-741
Range on HMM: 1-208/270
Sequence Identity: 32% (67 aa)

FDETRLLGVGGFGRVYKGEID----NGTLEVAVKRGNPRSEQG---IAEFQAEIGLLSKL-RHRHLVSLIGYCD-EQSE--MILVYEYMARGPLRGHLYG
    . || | ||.||||. .    |....||||  .. . .    ...| .|. ....| .| ..|.|.| |  ..    ...| |||. | |. .|  
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

T-EDLQPLPWRHRLEILVGAARGLHYLHTGAAIIHRDVKTTNILLDEHLVAKVSDFGLSKTGPMLDQT-HVSTAVKGSFGYLDPEYFRRQQLTDKSDVYS
  || |||.  . |.. .  |.|. ||.    .||||. . |.|..| .|.|..||||...    |.  ....  |     . || ..    | ||||.|
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN-CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDVWS

FGVVMVEVM
|||.| |..
FGVLMWEIF
Kinase IRAK-14_e.AA Pkinase 546-745 28 2.5e-38 136.58 Pfam 1-210 (293) Show / Hide 
Range on Protein: 546-745
Range on HMM: 1-210/293
Sequence Identity: 28% (61 aa)

FDETRLLGVGGFGRVYKGEIDNGTLEVAVKRGNPRSEQGIAEFQA-----EIGLLSKLRHRHLVSLIGYCDEQSEMILVYEYMARG----PLRGHLYGTE
.   | .| |.||.|||.   .   .||||. . | ..   . |.     || .. .|.| . | |.... . ... .| ||.  |     |  .. . .
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYIST-W

DLQPL--PWRHRLEILVGAARGLHYLHTGAAIIHRDVKTTNILLDEHLVA----KVSDFGLSKTGPMLDQTHVSTAVKGSFGYLDPEYFR-RQQLTDKSD
.  ..  ....   ..   .||| |.|    |||||.|  |||.|.. .     |..||||.|    .   .  | . |. .|. ||  | .|  . |.|
RHGCFYFSEWECKFYMYQILRGLEYCHS-MGIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVD

VYSFGVVMVEVMCARP
..|.|... |..| ||
MWSCGCILYEMLCGRP
Kinase IRAK-14_e.AA TK 546-741 16 3.8e-38 124.94 In-house 1-388 (486) Show / Hide 
Range on Protein: 546-741
Range on HMM: 1-388/486
Sequence Identity: 16% (65 aa)

FDETRLLGVGGFG---RVYKGEI-------------------------DNGTLEVAVKRGNPRSEQGIAEFQA-----------------EIGLLS--KL
    . || | ||   .|||||                          ..|. .||||   . ...  .||..                 |. ...  ..
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHRHLVSLIGYCDEQ------------SEMILVYEYMARGP----LRGHLYGTEDLQP------------------------------------------
.| ..|.|.|.| ..              ...| |||. |     || .|    .                                             
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------LPWRHRLEILVGAARGLHYLHTGA-----AIIHRDVKTTNILLDEHLV-----------AKVSDFGLSK
                               |. ...| . . .|.|. |||         ..|||. . |.|..|..|           .|..|||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

TG-----PMLDQTHVSTAVKGSFG---------------------------YLDPEYFRRQQ---------LTDKSDVYSFGVVMVEVM
.|       ... .  .....  .                           .. || .. ..          | ||||.||||.| |..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIF
Kinase IRAK-14_e.AA Dicty4 546-736 33 4.2e-38 124.8 In-house 1-206 (277) Show / Hide 
Range on Protein: 546-736
Range on HMM: 1-206/277
Sequence Identity: 33% (69 aa)

FDETRLLGVGGFGRVYKGEIDNGTLEVAVKRG---NPR-SEQGIAEFQAEIGLLSKLRHRHLVSLIGYCD----EQSEMILVYEYMARGPLRGHLYG---
 . . ..| |.|| ||||    |. |||||     |   .|  . || .|. ...|.|| ... . |.|     . ..|  | ||| .| |   |     
INIEQRIGKGSFGEVYKGTW-RGK-EVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPS

-TEDLQPLPWRHRLE---ILVGAARGLHYLHT-GAAIIHRDVKTTNILLDEHLVAKVSDFGLSK-TGPMLDQTHVSTAVKGSFGYLDPEYFRRQQLTDKS
   .  .|.|  ..    .   ||||. .||.    ||||| |. |.| |.....||.|||||.   .  |..   ....|. ..  ||  . |  . |.
EQQQSIKLDWPLIKRAMRMAFDAARGMNWLHCCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFGVV
|||||| |
DVYSFGIV
Kinase IRAK-14_e.AA MLK 546-741 28 1.5e-37 127.87 In-house 1-230 (291) Show / Hide 
Range on Protein: 546-741
Range on HMM: 1-230/291
Sequence Identity: 28% (67 aa)

FDETRLLGVGGFGRVYKGEIDNGT---LEVAVKRGNPRSEQGIAE-------FQAEIGLLSKLRHRH----LVSLIGYCDEQ-SEMILVYEYMARGPLRG
... . .|.|.|| |.||.  | .    .||||| . | .  ...       |. |. .|..|.|.      . . | | .. ..  .| ||.. |.|  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYN

HLYGTEDLQP-----------LPWRHRLEILVGAARGLHYLHTGA--AIIHRDVKTTNILLDE------HLVAKVSDFGLSKTGPMLDQTHVS--TAVKG
 |.| ..               .  | . . .  |||.||||  |  .||||| |  |||.||      |...|..|||.|.   .. |.. .  .  .|
VLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSR---DWHQMC-TNMMSNAG

SFGYLDPEYF---RRQQLTDKSDVYSFGVVMVEVM
.. .  || .   | .. . |.||.|.|||. |..
TYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEML
Kinase IRAK-14_e.AA TyrKc 546-821 24 3.6e-34 120.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 546-821
Range on HMM: 1-280/280
Sequence Identity: 24% (74 aa)

FDETRLLGVGGFGRVYKGEIDNGTLEVAVKRGNPRSEQGIAEFQAEIGLLSKL--RHRHLVSLIGYCDEQ-------SEMILVYEYMARGPLRGHLYGTE
    . || | ||.||||. .   ..||||  .. .   ...|  |. ...||  .| ..| |.|.| .|         . .| |||. | |. .|  ..
ITLGKKLGEGAFGEVYKGTWK---IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHR

DLQPLPWRHRLEILVGAARGLHYLHTGAAIIHRDVKTTNILLDEHLVAKVSDFGLSKTGPML-------DQTHVST--AVK--GSFGYLDPEYFRRQQLT
.   |.... |.. . .|.|  |||    .||||  . |.|..| ...|.||||||. .          |  ....    |       . || ..    |
PK--LCMKDLLSFCWQIACGMEYLHSK-NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFT

DKSDVYSFGVVMVEVM--CARPAIDPAL-PREQVNIAEWAMSAQRSGRLEEILDPTLRRPGSDEDADMASVRKVGETADKCLQENGVQRPSMGDVLWNL
 ||||.||||.| |..  .. |  .... . .   . |. ..  |  . .... | .    .          .. .   .| .|.  .||.. ..   .
TKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS---F-----VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-14_e.AA RIPK 552-741 30 5.4e-34 113.22 In-house 1-222 (290) Show / Hide 
Range on Protein: 552-741
Range on HMM: 1-222/290
Sequence Identity: 30% (67 aa)

LGVGGFGRVYKGEIDNGTLEVAVKR--GNPRS----EQGIAEFQAEIGLLSKLRHRHLVSLIGYCDEQ-----SE-MILVYEYMARGPLRGHLYGTEDL-
.| |||| |.|        .||.|   . ..     .|   .   |   . |||..| |.. | | .      .. . .| |||. | | . |    .  
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQ

-QPLPWRHRLEILVGAARGLHYLHTGA-AIIHRDVKTTNILLDEHLVAKVSDFGLSKTGPMLDQTH-------VST---AVK-GSFGYLDPEYFR---RQ
 .|.||  |  ...  ..| .|||     ||||| |. |||.| .. .|..||||..   .  ..        |.    . . |   |..|| ||   . 
HHPDPWPLRCRMIHEISCGMCYLHSMNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFRTDNKK

Q---LTDKSDVYSFGVVMVEVM
     | |.|||||..|| ||.
PIKVVTPKYDVYSFAIVMWEVL
Kinase IRAK-14_e.AA UTK 550-741 26 1.5e-33 112.19 In-house 5-234 (296) Show / Hide 
Range on Protein: 550-741
Range on HMM: 5-234/296
Sequence Identity: 26% (64 aa)

RLLGVGGFGRVYKGEIDN-----GTLEVAVKRGNPRSE--QGIA---EFQAEIG---LLSKLR-HRHLVSLIGYCDEQSEMILVYEYMARGPLRGHLYGT
|.|| | || |.|.. ..     ... ||||  ....   |  .   .|  |     ...... |.... |.|.|  .. ...|.|||..| ||  |   
RQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRH

EDLQP-----LPWRHRLEILVGAARGLHYLHTGAAIIHRDVKTTNILLDEH-------LVAKVSDFG---LSKTGP------------MLDQTHVST---
 . .|     |  ..||.  .  |||..|||.   ..|||.   |.|...|       .|.|..|||   .|.  .            .  ..|.     
RPTPPACPHWLTLHQRLCMAWDIARGMQYLHSC-GFVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQDRWPI

---AVKGSFGYLDPEYFRRQ-QLTDKSDVYSFGVVMVEVM
   |         || .  . . | ||||.|||||. |..
RWMA---------PEALTHHTRFTTKSDVWSFGVVCWEIW
Kinase IRAK-14_e.AA TK-Unique 546-742 23 6.5e-32 107.39 In-house 1-234 (294) Show / Hide 
Range on Protein: 546-742
Range on HMM: 1-234/294
Sequence Identity: 23% (56 aa)

FDETRLLGVGGFGRVYKGEIDNGT------LEVAVKRGN-PRSEQGIAEFQAEIGLLSKLR-HRHLVSLIGYCDEQS-EMILVYEYMARGPLRGHLYGTE
.   ...| | || |..||. ...        ||||  . . ...  ..|  || ....|  | ..|...|.| . .  . ...||...| |...|  . 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

DL--QP---------------------LPWRHRLEILVGAARGLHYLHT-GAAIIHRDVKTTNILLDEHLVAKVSDFGLSK---TGPMLDQTHVSTA--V
.   |.                     .  .  . .... |.|. ||.     |.|||. . |.|| |..|.|..|||...   |    .. ....    
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKIVHRDLCARNVLLTEDKVCKICDFGMARDVYT----NGVYSMMCSQG

KGSFGYLDPEYFR--RQQL-TDKSDVYSFGVVMVEVMC
. .  .. ||...  ...  | ||||.||||.| |...
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK-14_e.AA DRK 553-741 35 1.5e-30 100.68 In-house 8-196 (258) Show / Hide 
Range on Protein: 553-741
Range on HMM: 8-196/258
Sequence Identity: 35% (69 aa)

GVGGFGRVYKGEIDNGTLEVAVKRGNPRSEQ---GIAEFQAEIGLLSKLRHRHLVSLIGYCDEQSEMILVYEYMARGPLRGHLYGTEDLQPLPWRHRLEI
| |..| |. |    || .||||.     .     . ||. || |...|||   .  .| | . ..   . ||| || |   |   | .. . |  .. .
GRGNYGEVFRGTW-RGT-QVAVKMLFNHNINDENFLNEFHREINLMCQLRHPNICQFMGTCNNPPDICICMEYMPRGSLYNILH-DESIE-MDWPLMKQM

LVGAARGLHYLHTGA-AIIHRDVKTTNILLDEHLVAKVSDFGLSKT--GPMLDQTHVSTAVKGSFGYLDPEYFRRQQLTDKSDVYSFGVVMVEVM
   .|.|. |||     ||||| |. | | |||   ||.||||| |    .....   |.. |  .   ||  | |  | | |||||..|  |..
MFDCAKGMIYLHCCNPIIIHRDLKSHNLLVDEHWQVKVADFGLS-TRFKKHKQHKFAMTMC-GTPCWTAPEVLRNQRYTEKADVYSFAIVLWECV
Kinase IRAK-14_e.AA S_TKc 546-825 22 1e-27 99.3 SMART 1-231 (231) Show / Hide 
Range on Protein: 546-825
Range on HMM: 1-231/231
Sequence Identity: 22% (66 aa)

FDETRLLGVGGFGRVYKGEIDNGTLEVAVKRGNPRSEQGIAEFQAEIGLLSKLRHRHLVSLIGYCDEQSEMILVYEYMAR--GPLRGHLYGTEDL---QP
..  |..| |.||.|||.   .   .||.|. .         .. || .|.| .| ..| |...... ... .| ||.    | |. ..         .|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

LPWRHRLEILVGAARGLHYLHTGAAIIHRDVKTTNILLDEHLVAKVSDFGLSKTGPMLDQTHVSTAVKGSFGYLDPEYFRRQQLTD-KSDVYSFGVVMVE
.|  |   ..   ...| |.|    |||||.|  ||||||  . |..||||..           | . |.  |. || .   . .  |.|..|.|... |
FPE-HARFYMYQICCALEYCHSH-GIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

VMCARPAIDPALPREQVNIAEWAMSAQRSGRLEEILDPTLRRPGSDEDADMASVRKVGETADKCLQENGVQRPSMGDVLW-----NLESAL
 .| .|  .     ..  . .  .                            |        .|||| .  .||.  ..|      ..   .
MLCGYPPFP-----QMQMMFKKIG----------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-14_e.AA DRK 803-823 42 8.8e-05 12.17 In-house 238-258 (258) Show / Hide 
Range on Protein: 803-823
Range on HMM: 238-258/258
Sequence Identity: 42% (9 aa)

CLQENGVQRPSMGDVLWNLES
|. |.  .|||| ..|  ||.
CWNEDPQHRPSMQECLERLEA
Kinase IRAK-14_e.AA Dicty4 802-823 25 0.024838 3.78 In-house 254-277 (277) Show / Hide 
Range on Protein: 802-823
Range on HMM: 254-277/277
Sequence Identity: 25% (6 aa)

KCLQENGVQRPSMGDVLWN--LES
.|. ..  .|||.  ..    ||.
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAK-14_e.AA MLK 802-821 25 0.284188 0.33 In-house 272-291 (291) Show / Hide 
Range on Protein: 802-821
Range on HMM: 272-291/291
Sequence Identity: 25% (5 aa)

KCLQENGVQRPSMGDVLWNL
.| ...  .|||.  ..  |
QCWNQDPHKRPSFRQIVQHL