Gene IRAK-Un_dh (S.moellendorffii)

IRAK-Un_dh

Species: S.moellendorffii
Alias: IRAK-Un_dh
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_dh.AA Protein None 873 None Fasta, JSON
IRAK-Un_dh.NA RNA None 2622 None Fasta, JSON
IRAK-Un_dh.kin_dom Protein Kinase Domain None 290 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_dh.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
B_lectin IRAK-Un_dh.AA B_lectin 106-206 27 9e-22 76.4 Pfam 1-137 (137) Show / Hide 
Range on Protein: 106-206
Range on HMM: 1-137/137
Sequence Identity: 27% (38 aa)

RPVVLWTANRD---RYF-----GEGATLDFGA-DGELIVRENG---LT--VWST--GTAGKG---VTEMCITNLGNLLLR-NST--DHIIWQS--FDSPS
 . | |.||||   .       ....|| . . || |.. ..|    .  ||||  .|.|.|    . . ... ||| |. ..   ....|||  || |.
NQTVVWVANRDLTGNPVTDSSNNGNYTLTMQNRDGNLVLYDGGNGGSVRPVWSTNNNTSGSGSANNCRAQMQDSGNLVLYDDNNDSNNVLWQSNTFDHPT

DT-IPMQV----AFKP-GNR----LVSWASLK--DSS
||  | .      ..  . .    |.||.|    | |
DTWLPGMKLGWDNNVTIYMNWIGYLTSWKSNTNYDPS
B_lectin IRAK-Un_dh.AA B_lectin 52-180 23 2e-06 23.68 SMART 1-126 (126) Show / Hide 
Range on Protein: 52-180
Range on HMM: 1-126/126
Sequence Identity: 23% (33 aa)

TDGLSGRYTGYWSNTTY-IELGDITFQLWFLTYDARNFTLSLVAMREPTQEWELYRPVVLWTA--NRDRYFGEG---ATLDFGADGELIVRENGLTVWST
.  ||.  | . .|... ..||. ||.          .... .    . .        |.| |  |||.   .|   ..| .. ||.|..   . .|||.
DNTLSSGQTLVSGNSLFEFYLGFFTFIMQ--------WCNGIWYKNISNK-----QRTVVWVAQPNRDNPVHDGNNSCYLTMQSDGNLVIYD-NRPVWSS

GTA-GKGVTEMCITNLGNLLLRNST----DHIIWQSFDSP
.|. ..|.. .  .  ||. ....     . .||||||.|
NTTRNNGNYVAVLQDDGNFVIYDPDDNDSGNFIWQSFDHP
PAN_AP IRAK-Un_dh.AA PAN_AP 379-453 20 0.000799 16.0 SMART 1-85 (85) Show / Hide 
Range on Protein: 379-453
Range on HMM: 1-85/85
Sequence Identity: 20% (18 aa)

CEPHEIVRMEGVDYFSTNFSRE------VPVVDESECRRRCEENCSCMAAFFKE-KSCFQTH--EPIQSMI------TGEYTGLLKVAKT
|...  |||... .    ||.       . |... ||...| .||||... . . |.|   .   . ...       ...  |     |.
CCDDCFVRMPNMKL----FSPIVNWVDVI-VMSLEECMQKCLNNCSCRSFMYYNTKGCHLWSWDSHLGDPRQFKRFMKFPNQGVDYYEKN
Kinase IRAK-Un_dh.AA TKL 534-820 22 2.9e-68 233.08 In-house 1-364 (364) Show / Hide 
Range on Protein: 534-820
Range on HMM: 1-364/364
Sequence Identity: 22% (89 aa)

LGQGGYGSVYRGSLED---------GNQVAVKKLQGSN----------------------------QTSRDFYAELASLARTNHLNLVKFIGFCAEGPR-
.|.||.| ||.| .           |. |||||.   |                            .    .  |. .. |..| |.|.|.|.| ..|  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------KRLLVYEFVANGSLEKWIFVDGGGDDDSSSQQQDGSGGLSWDFKFRIAVGTAQGLCYLHE----ECAEK--IIHLDLKPENVLVDIGFV
           .  .|.|.. .|||.  .                      |. ..|.| ..|.|..|||      |  |  ||| |||..|.|||  . 
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH---------------------WHQRCRWALDIARGMNYLHSMNPKWCT-KPPIIHRDLKSKNILVDENWT

--------------PKIADFGLSKLMNRE-----------------VTYLQMTSMRGTPGYLAPEYLQ----------------VGTITEKSDVFSFGVL
              .||.|||||. |...                 ..  .  . .|||...||| |.                 .. .||.||.|||..
NVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIV

LLEIITGCRNKYMSSDYLRSFSLGDFSRQKSFTKSIS----KTRKNLCDGGSSGGVADKYQ--------AAGMERLKAVAYLCVQDDPDMRPSMSTALKM
| ||.|.||                .. .....  ..       .  || |    . .  |           ....|  .  | . ||. |||... || 
LWEILTRCR---------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKR

M
.
L
Pkinase IRAK-Un_dh.AA Pkinase 528-738 26 4.2e-48 170.92 Pfam 1-208 (293) Show / Hide 
Range on Protein: 528-738
Range on HMM: 1-208/293
Sequence Identity: 26% (61 aa)

GGFSKCLGQGGYGSVYRGSLEDGNQ-VAVKKLQGSNQTSRDFYA-----ELASLARTNHLNLVKFIGFCAEGPRKRLLVYEFVANG----SLEKWIFVDG
  . ...|.|..|.||..   . .. ||||..  ... |   ..     |.. ..| || | |...... . ...  .| |.. .|    .|  .| .  
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED-KDHIYMVMEYCEGGLYVMDLFDYIST--

GGDDDSSSQQQDGSGGL--SWDFKFRIAVGTAQGLCYLHEECAEKIIHLDLKPENVLVDIGFVP----KIADFGLSKLMNREVTYLQMTSMRGTPGYLAP
           . .|..  |..   ...  ...|| |.|..   .||| ||||||.|.|   ..    ||.||||.|... .  .  ||.  |||.|.||
-----------WRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFD-Y-NNS-MTTFCGTPWYMAP

EYLQ-VGTITEKSDVFSFGVLLLEIITG
| ..    .. |.|..|.|..| | ..|
EVIRGGQYYGPKVDMWSCGCILYEMLCG
Kinase IRAK-Un_dh.AA MLK 530-738 28 2e-41 141.51 In-house 3-232 (291) Show / Hide 
Range on Protein: 530-738
Range on HMM: 3-232/291
Sequence Identity: 28% (66 aa)

FSKCLGQGGYGSVYRGSLEDGN----QVAVKKLQ-------GSNQTSRDFYAELASLARTNHLN----LVKFIGFCAEGPRKRLLVYEFVANGSLEKWIF
|.. .| |..|.|..|     .     ||||.          .   ..||  |   |.. .|.|     ..| | |.. | . ..| |....|||   . 
FHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLH

V-DGGGDDDSSSQQQDGSGGLSWDFKFRIAVGTAQGLCYLHEECAEKIIHLDLKPENVLVDI------GFVPKIADFGLSKLMNRE-VTYLQMTSMRGTP
  .....|    .|.  ..  . |.....|.  |.|. |||..   .||| |||. |.|.|       . . ||.|||.|. ...   .   |.|..||.
GARSKWMDAN-HNQK-NDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTN---MMSNAGTY

GYLAPEYL---QVGTITEKSDVFSFGVLLLEIITG
 . ||| .   . .. .||.||.|.||.| |..|.
AWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTR
Kinase IRAK-Un_dh.AA Dicty4 530-738 34 1.3e-37 123.12 In-house 3-213 (277) Show / Hide 
Range on Protein: 530-738
Range on HMM: 3-213/277
Sequence Identity: 34% (76 aa)

FSKCLGQGGYGSVYRGSLEDGNQVAVKKLQGSNQTS-----RDFYAELASLARTNHLNLVKFIGFCA---EGPRKRLLVYEFVANGSLEKWIFVDGGGDD
. . .|.|..|.||.|.   | .||||||   ||..      .| .| . ..   | |...| | |      | | . | |..  |.|.. .       |
IEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLH------D

DSSSQQQDGSGGLSWDFKFR---IAVGTAQGLCYLHE-ECAEKIIHLDLKPENVLVDIGFVPKIADFGLSKLMNREVTYLQ-MTSMRGTPGYLAPEYLQV
  | |||  |  |.|    |   .|  .|.|. .||.  .   |||.|||. | |||. .. |..|||||..| .. .  . .... |||.. ||| .. 
KPSEQQQ--SIKLDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMH

GTITEKSDVFSFGVLLLEIITG
   .||.||.||| .| || |.
QPYNEKADVYSFGIVLWEILTR
Kinase IRAK-Un_dh.AA TK 530-820 16 1.3e-33 109.43 In-house 3-486 (486) Show / Hide 
Range on Protein: 530-820
Range on HMM: 3-486/486
Sequence Identity: 16% (84 aa)

FSKCLGQGGYG---SVYRGSLEDGN--------------------------QVAVKKLQ-GSNQTSRDFYA--------------ELASLARTN-----H
. | ||.| .|    ||.| ....|                          .|||| |  |.......| .              |.. ..  .     |
LGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHH

LNLVKFIGFCAEGPRK-----------RLLVYEFVANGS----LEKWIFVDGGGDDDSSSQQQDGSGG--------------------------------
 |.|...| | .|  |            ..| |....|.    | ..     ..  ....  .... .                                
PNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDD

-----------------------------LSWDFKFRIAVGTAQGLCYLHEE----CAEKIIHLDLKPENVLVDIGFV-----------PKIADFG----
                             |.   .  ...  |.|. |||.        ...| ||   |.||. . |            ||||||    
DLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQ

----LSKLMNREVTYLQMTSMRGTPG------------------------YLAPEYLQ---------VGTITEKSDVFSFGVLLLEIITGC-RNKY--MS
    |.. ....  |  ..| ... .                        ..||| |.          |. |.||||.|||||. || | .    |  ||
GSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGMS

S-----DYLRSFSLGDFSRQKSFTKSISKTRKNLCDGG----SSGGVADKYQAAGMERLK-----------------------AVAYLCVQDDPDMRPSM
.     |                  .     ..|..||    | |   .  .  .|.. .                        .   | . ||. ||..
NQDVWKD----------------G-DNQEVMEYLRRGGRLCRS-G-L-N-EVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTF

STALKMM
|. ....
SQLHEQL
Kinase IRAK-Un_dh.AA Ciliate-E2 530-738 21 4.1e-33 111.02 In-house 3-292 (365) Show / Hide 
Range on Protein: 530-738
Range on HMM: 3-292/365
Sequence Identity: 21% (66 aa)

FSKCLGQGGYGSVYRGSL------------------------EDGNQVAVKKLQGSNQTSRD----FY----------AELASLARTNHLNLVKFIGFCA
| |..|||..||||...                          .....|.| .. ..  .       .           |.  | . || |..|.. .  
FIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYECFQ

E-GPRKRLLVYEFVANGSLEKWI----------FVDGGGDDDSSSQQQDGSGGLSWDFKFRIAVGTAQ---------------GLCYLHEECAEKIIHLD
|    .  || |..  |.|...|          .             . . . ...    .|    .|               .| |||..    ||| |
EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIE------------K-D-KYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN--IIHRD

LKPENVLVDIGFVPKIADFGLSK----------------------LMNREVTYL-------QMTSMRGTPGYLAPEYLQVGT---------ITEKSDVFS
.||||.|.     .||.||||||                       ..|  .|.       .  .  |||||.||| |. .           ..|.|..|
IKPENILF-----IKIIDFGLSKKYDDDNQNRTHKQQCKWYMFKNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWS

FGVLLLEIITG
.||.| | ..|
LGVILYEMLFG
S_TKc IRAK-Un_dh.AA S_TKc 528-824 21 7.6e-32 113.03 SMART 1-231 (231) Show / Hide 
Range on Protein: 528-824
Range on HMM: 1-231/231
Sequence Identity: 21% (68 aa)

GGFSKCLGQGGYGSVYRGSLED-GNQVAVKKLQGSNQTSRDFYAELASLARTNHLNLVKFIGFCAEGPRKRLLVYEFVAN--GSLEKWIFVDGGGDDDSS
  . . .|.|..|.||..   . | .||.|..       .... |.. | . .| |.||..... .   .  .| |.. .  |.| . |           
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYI-----------

SQQQDGSGG----LSWDFKFRIAVGTAQGLCYLHEECAEKIIHLDLKPENVLVDIGFVPKIADFGLSKLMNREVTYLQMTSMRGTPGYLAPEYLQVGTIT
  .. |..|    ..     ...  ....| |.|.    .||| ||||||.|.|   . ||.||||....         |.. ||| |.||| |     .
--KKRGRHGLRFPFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL---------TTFCGTPWYMAPEVL---GYG

E-KSDVFSFGVLLLEIITGCR---NKYMSSDYLRSFSLGDFSRQKSFTKSISKTRKNLCDGGSSGGVADKYQAAGMERLKAVAYLCVQDDPDMRPSMSTA
  |.|. |.|..| | ..|.    . .|  . ..                                          . .|     | | ||. ||.   |
KCKCDWWSCGCILYEMLCGYPPFPQMQMMFKKIG-----------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EA

LK-----MMEGLI
|.     ..   .
LQDEWDIKCHPWF
Kinase IRAK-Un_dh.AA TyrKc 530-820 22 6.5e-31 109.95 SMART 3-280 (280) Show / Hide 
Range on Protein: 530-820
Range on HMM: 3-280/280
Sequence Identity: 22% (73 aa)

FSKCLGQGGYGSVYRGSLEDGNQVAVKKLQGSNQTSRDFYAELASLART--NHLNLVKFIGFCAEGP------RKRLLVYEFVANGSLEKWIFVDGGGDD
. | || | .| ||.| .    |||||.|. .    .||. |.  . .   .| |.|...| | ..          ..| |....|.| . .   ..   
LGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--

DSSSQQQDGSGGLSWDFKFRIAVGTAQGLCYLHEECAEKIIHLDLKPENVLVDIGFVPKIADFGLSKLMNRE-------VTYLQMT--SMR--GTPGYLA
            |... .  ...  |.|  |||.    ..|| ||   |.||. ... ||.|||||.    .        .| ...  . .       .|
------------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMA

PEYLQVGTITEKSDVFSFGVLLLEIITGCRNKY-------MSSDYLRSFSLGDFSRQKSFT--KSISKTRKNLCDGGSSGGVADKYQAAGMERLKAVAYL
|| .. |. |.||||.||||.. || | .   |       || . .. .    . . .       .|                  .     . .  .   
PECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MS------------------F-VCCPDEMYQIMKQ

CVQDDPDMRPSMSTALKMM
| . ||..||..|.  . .
CWHEDPEDRPTFSEIHECF
Kinase IRAK-Un_dh.AA Pkinase_Tyr 530-740 29 8.6e-31 104.91 Pfam 3-212 (270) Show / Hide 
Range on Protein: 530-740
Range on HMM: 3-212/270
Sequence Identity: 29% (65 aa)

FSKCLGQGGYGSVYRGSLE-----DGNQVAVKKL-QGSNQT---SRDFYAELASLART-NHLNLVKFIGFCA-EGPR-KRLLVYEFVANGSLEKWIFVDG
| | ||.| .|.||.| .      .. .||||.| .|. .    ..|| .|.. .    .| |.|...| |  .|   . ..| |....|.| .      
FGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR

GGDDDSSSQQQDGSGGLSWDFKFRIAVGTAQGLCYLHEECAEKIIHLDLKPENVLVDIGFVPKIADFGLSKLMNREVTY-LQMTSMRGTPGYLAPEYLQV
           .. . |.   .  ...  |.|. ||..     .|| ||   |.||. ..| ||.||||....  . .|  . .. .     .||| .. 
-----------EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINY

GTITEKSDVFSFGVLLLEIITGCR
|  |.|||| |||||. ||.| ..
GKFTTKSDVWSFGVLMWEIFTYGE
Kinase IRAK-Un_dh.AA STE 530-739 21 9.2e-31 105.9 In-house 1-265 (359) Show / Hide 
Range on Protein: 530-739
Range on HMM: 1-265/359
Sequence Identity: 21% (58 aa)

FSK--CLGQGGYGSVYRGSLED----------------GNQVAVKKLQ--GSN----------------QTSRDFYAELASLARTN--HLNLVKFIGFCA
. .  ..|.|..|.||..   .                |. .|.|..    .|                .   ..  |.  . . |  | | ||..| . 
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EGPR------KRLLVYEFVANGSLEKWIF-VDGGGDDDSSSQQQDGSGGLSWDFKFRIAVGTAQG-LCYLHEECAEKIIHLDLKPENVLVDIGFVPKIAD
 . .      .  .. |....|||.. |  . | |.......|.  .. .. .   .|.. . .| | |||.     ||| |.|| |.|.      |..|
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQH--QHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCD

FGLSKLMNREV-------------TYLQMT-SMRGTPGYLAPEYLQV------GTITEKSDVFSFGVLLLEIITGC
||... .. ..             |  |.. .. ||| . ||| .|       .  ..|.|. |.| ...| .||.
FGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-Un_dh.AA RIPK 534-738 27 1.6e-29 97.74 In-house 1-224 (290) Show / Hide 
Range on Protein: 534-738
Range on HMM: 1-224/290
Sequence Identity: 27% (66 aa)

LGQGGYGSVYRGSLEDGNQVAVKKL-QGSN-------QTSRDFYAELASLARTNHLNLVKFIGFCAEG----PRK-RLLVYEFVANGSLE-----KWIFV
.| || | |..    . . ...||   . .       | . .   | . ...  . . |.  ||| .     . |   .| |. .||||.     || . 
VGGGGFGEVFKARHRHWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPY-

DGGGDDDSSSQQQDGSGGLSWDFKFRIAVGTAQGLCYLHEECAEK--IIHLDLKPENVLVDIGFVPKIADFGLSKLMNRE-VTY--------LQMTSMR-
          |...    . |. ..|. . .. | ||||     .  |||.||||||.|||  |  |||||||.. |    ..         . |.|   
----------QHHP----DPWPLRCRMIHEISCGMCYLHS---MNPPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNR

-GTPGYLAPEYLQ------VGTITEKSDVFSFGVLLLEIITG
 ||  |..|| .       .  .|.|.|| ||.... |. |.
WGTLSYMPPEHFRTDNKKPIKVVTPKYDVYSFAIVMWEVLTQ
Kinase IRAK-Un_dh.AA IRAK 628-740 42 1.8e-29 101.7 In-house 97-222 (317) Show / Hide 
Range on Protein: 628-740
Range on HMM: 97-222/317
Sequence Identity: 42% (54 aa)

QDGSGG---LSWDFKFRIAVGTAQGLCYLHEEC-AEKIIHLDLKPENVLVDIGFVPKIADFGLSKLM----NREVTYL--QMTS-MRGTPGYLAPEYLQ-
|||..    |||   . |. ||| |. .||.   .  ||| | |. |.| |  |.|||.||||        ..| . .   |||  |||  |..||..  
QDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRD

-VGTITEKSDVFSFGVLLLEIITGCR
 .| .| |.||.|||. |||..||||
PQGQLTKKTDVYSFGIVLLEVLTGCR
Kinase IRAK-Un_dh.AA LRRK 528-738 23 8.5e-29 98.99 In-house 1-278 (351) Show / Hide 
Range on Protein: 528-738
Range on HMM: 1-278/351
Sequence Identity: 23% (70 aa)

GGFSKCLGQGGYG-SVYRGSLED---------------------------GNQVAVKKLQGS---------NQTS-------------------------
  . . .|.||.| .|||. ...                           .. ||.||.            | .                          
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-RDFYAELASLARTNHLNLVKFIGFCAEGPRKRLLVYEFVANGSLEKWIF---VDG----GGDDDSSSQQQDGSGGLSWDFKFRIAVGTAQGLCYLHEEC
 | |  |.. . . || |.|. .||| . ..   .| |.. .|.| . ..    ||                    .|| .| .||.  | |. |||   
FREFRHEVWIMSHLNHPNIVSLKGFCIHPLC---MVMEYAPHGDLYHFLHNKKQDGFHFMK-------------AHISWMLKLKIALQIAKGMEYLHS--

AEK--IIHLDLKPENVLV-DI-----------GFVPKIADFGLSKLMNREVTYLQ-MTSMRGTPGYLAPEYLQVG---TITEKSDVFSFGVLLLEIITG
  .  ||| |||..|.|.  .             . ||||||.|  |   ...      . |.||..||| .. .   . |||.|..|||..| |..|.
-HNPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCAKIADFGISR-MF-QCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTR
Kinase IRAK-Un_dh.AA TKL-Unique 634-740 35 7.5e-24 81.11 In-house 107-226 (290) Show / Hide 
Range on Protein: 634-740
Range on HMM: 107-226/290
Sequence Identity: 35% (43 aa)

LSWDFKFRIAVGTAQGLCYLHEECAEKIIHLDLKPENVLVDIG-----FVPKIADFGLSKLMNRE-VTYLQMT------SMRGTPGYLAPEYLQV--GTI
|..  . ..|   |||..||| . .  |||.|||. |.||| .     .  ||.||||||. ...  . . .       .  |.. ..||| |     ..
LNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQY

TEKSDVFSFGVLLLEIITGCR
.|||||.|||. | ||.|...
SEKSDVYSFGIVLWEIATRKI
Kinase IRAK-Un_dh.AA IRAK 530-610 36 1.7e-15 51.54 In-house 1-91 (317) Show / Hide 
Range on Protein: 530-610
Range on HMM: 1-91/317
Sequence Identity: 36% (34 aa)

FSK--CLGQGGYGSVYRGSLEDGNQ--VAVKKLQGSNQTS-----RDFYA---ELASLARTNHLNLVKFIGFCAEGPRKRLLVYEFVANGSLE
|.|   .|.||.| |||| . ...   .|||||   . .|     . | .   || ...|  | |.| . |.|.|.. .  |||.. .|||||
FHKDNRIGEGGFGCVYRGQW-KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQ-CHCLVYPYMPNGSLE
Kinase IRAK-Un_dh.AA TKL-Unique 530-611 31 1.4e-14 48.01 In-house 1-89 (290) Show / Hide 
Range on Protein: 530-611
Range on HMM: 1-89/290
Sequence Identity: 31% (28 aa)

FSKCLGQGGYGSVYRGSLEDGNQVAVKKLQ----GSNQTSRDFYAELASLARTN-HLNLVKFIGFCAE---GPRKRLLVYEFVANGSLEK
|.. .|.||||.||.|    | .||.|..      ||. ...|. |.  . . . | |.|...|.|.     | .. .| |..  ||| .
FWNKIGEGGYGQVYKGKWR-GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYD
Kinase IRAK-Un_dh.AA LRRK 801-822 36 0.005211 6.47 In-house 330-351 (351) Show / Hide 
Range on Protein: 801-822
Range on HMM: 330-351/351
Sequence Identity: 36% (8 aa)

LCVQDDPDMRPSMSTALKMMEG
.| | ||. ||..|. .| .. 
HCWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-Un_dh.AA MLK 802-820 31 0.130369 1.52 In-house 273-291 (291) Show / Hide 
Range on Protein: 802-820
Range on HMM: 273-291/291
Sequence Identity: 31% (6 aa)

CVQDDPDMRPSMSTALKMM
| ..||  |||..  ..  
CWNQDPHKRPSFRQIVQHL
Kinase IRAK-Un_dh.AA TKL-Unique 802-820 31 0.229181 0.8 In-house 272-290 (290) Show / Hide 
Range on Protein: 802-820
Range on HMM: 272-290/290
Sequence Identity: 31% (6 aa)

CVQDDPDMRPSMSTALKMM
|  .||. ||| .. ..  
CWHHDPSQRPSFDEIIHRL