Gene IRAK-Un_ck (S.moellendorffii)

IRAK-Un_ck

Species: S.moellendorffii
Alias: IRAK-Un_ck
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_ck.AA Protein None 649 None Fasta, JSON
IRAK-Un_ck.NA RNA None 1950 None Fasta, JSON
IRAK-Un_ck.kin_dom Protein Kinase Domain None 213 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_ck.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LysM IRAK-Un_ck.AA LysM 114-162 24 0.009109 7.46 SMART 1-45 (45) Show / Hide 
Range on Protein: 114-162
Range on HMM: 1-45/45
Sequence Identity: 24% (12 aa)

PYEIAPDDTTLFIIAQEKFQGLTRDDWIAEATPLKDKNTIFAGLNVKVP
 | . . | ||. ||| ...  .  . |... |... ..|..|   ..|
TYTVKKGD-TLWSIAQ-RYGITV--QDIMKWNPILNCDMIYPGQKLCIP
LysM IRAK-Un_ck.AA LysM 181-226 28 6.8e-10 40.11 SMART 1-45 (45) Show / Hide 
Range on Protein: 181-226
Range on HMM: 1-45/45
Sequence Identity: 28% (13 aa)

TYVVQPGDTLSTISARFKVPDQQLLQRFNPHIDFQRLIAQSIVFVP
||.|..||||. |..|....  | ... ||...  .. .     .|
TYTVKKGDTLWSIAQRYGITV-QDIMKWNPILNCDMIYPGQKLCIP
LysM IRAK-Un_ck.AA LysM 182-226 26 8.6e-08 30.39 Pfam 1-45 (45) Show / Hide 
Range on Protein: 182-226
Range on HMM: 1-45/45
Sequence Identity: 26% (12 aa)

YVVQPGDTLSTISARFKVPDQQLLQRFNPHIDFQR-LIAQSIVFVP
|.|..||||. |..|....  | ... ||... .. . .     .|
YTVKKGDTLWKIAQRYGTT-VQQIMEWNPNLKSPNHIYPGQKLCIP
Kinase IRAK-Un_ck.AA TKL 412-638 23 7.2e-53 181.96 In-house 88-364 (364) Show / Hide 
Range on Protein: 412-638
Range on HMM: 88-364/364
Sequence Identity: 23% (73 aa)

VQLIGYCTVES--------------LFLVYEFVDNGTLAQHLHSTTRPPLSWSSRIQIAMDAARGLEYIHEHA-----KPTYIHRDIKSTNILIDKNFH-
||..|||. ..              |..|.|....|.|  .||        |. |...|.|.|||..| | .      ||  ||||.|| |||.|.|.. 
VQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTN

-------------AKVADFGLSK-LTETG-MTSISLT------------QPTRLVGTFGYMSPEYARYG----------------DVSPFLDVYSFGVVL
             .|..|||||. ....| |. .. |            .  . .||...|.||  |                  . |.  ||||||.||
VSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVL

FEIISAQEAIVRTQSGILSNKDEQKGLATLFEDVLQD------------DTNGKERLRDLMDPRLGD----NYPLEAAWSLAKLAGACTKENPELRPNMR
.||.. ..                      ..|   .              .....|| ...|.  .      .  .  |..||.  | ...|| ||.. 
WEILTRCR---------------------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQ

TVVVAL
...  |
EILKRL
Kinase IRAK-Un_ck.AA IRAK 412-638 28 2.4e-40 140.34 In-house 66-317 (317) Show / Hide 
Range on Protein: 412-638
Range on HMM: 66-317/317
Sequence Identity: 28% (73 aa)

VQLIGYCTVESLF-LVYEFVDNGTLAQHLHSTTR--PP--LSWSSRIQIAMDAARGLEYIHEHA-KPTYIHRDIKSTNILIDKNFHAKVADFGLSKLT-E
| | |||| .. . |||..  ||.|   |. ..   ||  |||  |. |.  .|.|... |.   .   ||.|||| ||| |..| .| .||||     .
VPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHP

TG---MTSISLTQPTRLVGTFGYMSPEYAR--YGDVSPFLDVYSFGVVLFEIISAQEAIVRTQSG------ILSNKDEQKG-----LATLFEDVLQDDTN
..    ....     ...||  || ||. |   |  .. .||||||.|| |... . | .  ..       ....  |. |     . ||   |  |   
ASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWA

GKERL---RDLMDPRLGDNYPLEAAWSLAKLAGACTKENPELRPNMRTVVVAL
   |.    .. |.| ..  | . . ... .|. |. .   .|. |. |.  |
APRRMQIYEKFIDHRMPP-CPPNMEKEMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-Un_ck.AA TKL-Unique 412-553 31 2e-34 118.84 In-house 59-223 (290) Show / Hide 
Range on Protein: 412-553
Range on HMM: 59-223/290
Sequence Identity: 31% (53 aa)

VQLIGYCT----VES-LFLVYEFVDNGTLAQHLHS--------TTRPPLSWSSRIQIAMDAARGLEYIHEHAKPTYIHRDIKSTNILIDKN-----FHAK
|...|||.     .. ...| |... |.|  .||             .|... |...| |.|.|..|.|   .|  ||||.||.|.|.| |     . .|
VHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIK

VADFGLSKLTETGMTSISLTQ----PTRLVGTFGYMSPEYARY--GDVSPFLDVYSFGVVLFEIIS
..||||||.  . ..... .      .  .|.| .|.||  |    . |   ||||||.|| ||..
ICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVLRMNFCQYSEKSDVYSFGIVLWEIAT
Kinase IRAK-Un_ck.AA MLK 412-556 28 7.1e-30 100.89 In-house 72-234 (291) Show / Hide 
Range on Protein: 412-556
Range on HMM: 72-234/291
Sequence Identity: 28% (49 aa)

VQLIGYCTVE-S-LFLVYEFVDNGTLAQHLHS-TTRPP-----------LSWSSRIQIAMDAARGLEYIHEHAKPTYIHRDIKSTNILID------KNFH
.|. | |. . . ...| |....| |.  ||. .. .             . .. ...|.. |||..| |..|....||||.|| |||||      .. .
IQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGT

AKVADFGLSK-LTET-G-MTSISLTQPTRLVGTFGYMSPEY---ARYGDVSPFLDVYSFGVVLFEIISAQE
.|..|||.|. ....   |.|          ||. .|.||    .| . .|   ||.|.|||| |... ..
LKICDFGTSRDWHQMCTNMMS--------NAGTYAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREV
Kinase IRAK-Un_ck.AA Dicty5 423-557 31 2.8e-28 94.45 In-house 74-202 (260) Show / Hide 
Range on Protein: 423-557
Range on HMM: 74-202/260
Sequence Identity: 31% (44 aa)

LFLVYEFVDNGTLAQHLHSTTR---PPLSWSSRIQIAMDAARGLEYIHEHAKPTYIHRDIKSTNILIDKNFHAKVADFGLSK--LTETGMTSISLTQPTR
.| | |.. ||.|   |    .    |...  .. .|.|.|......|       ||||.|| |.|| .|. .|. ||| |       .||         
PFHVTEYCHNGSLFNYLNDQRKTTGQPIAYFQQLHMAIDIAQSMRHLHSMN---IIHRDLKSMNFLITENWKIKIIDFGTSRFVDNRYHMT---------

L-VGTFGYMSPEYARYGDVSPFLDVYSFGVVLFEIISAQEA
. |||  .|..|           ||||||.||.|..   |.
MHVGTQCWMACELFNGQPYHQKCDVYSFGIVLWEMFTRKEP
Kinase IRAK-Un_ck.AA LISK 422-552 29 1e-27 86.95 In-house 71-233 (296) Show / Hide 
Range on Protein: 422-552
Range on HMM: 71-233/296
Sequence Identity: 29% (49 aa)

SLFLVYEFVDNGTLAQHLHST--TRPPLSWSSRIQIAMDAARGLEYIHEHAKPTYIHRDIKSTNILIDKN----FHAKVADFGLSKLTETGMTS------
.|..| |... |.| | |...     ||.|. |. || | |.|..| |.      |||| ||.|.|...|    . .||.|||. .. .    |      
QLHIVTEYINGGDLHQYLKDMDKHKIPLPWPQRVKIALDIACGMSYLHSMN---IIHRDLKSKNCLVRENDNNQWRIKVCDFGFARMMDCENNSPCNMPR

---------------ISLTQP---TRL-----VGTFGYMSPEYARYGDVSPFLDVYSFGVVLFEII
                .. ..   .|      .||   |.||  .  . .   ||.|||.|| |||
EDESDPCMDNDMPMKRKIPKKCMNQRKRRMTICGTPYWMAPEMLLGQSYDESCDVFSFGIVLCEII
Kinase IRAK-Un_ck.AA LRRK 412-553 32 3.1e-26 89.78 In-house 120-277 (351) Show / Hide 
Range on Protein: 412-553
Range on HMM: 120-277/351
Sequence Identity: 32% (54 aa)

VQLIGYCTVESLFLVYEFVDNGTLAQHLHSTTRPP-------LSWSSRIQIAMDAARGLEYIHEHAKPTYIHRDIKSTNILI---D---------KNFHA
|.|.|.|  . | .| |....|.| ..||.. . .       .||. ...||.. |.|.|| | | .|  |||| || |||.   .          . .|
VSLKGFCI-HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSH-NPPIIHRDLKSPNILLWSSPQNHSPNYPNAHVCA

KVADFGLSK---LTETGMTSISLTQPTRLVGTFGYMSPEYARYG---DVSPFLDVYSFGVVLFEIIS
|.||||.|     . .| ..       ..||..|.|.||  ||.     .   |.||||..|.|...
KIADFGISRMFQCFHMGVAK-------GCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLT
TyrKc IRAK-Un_ck.AA TyrKc 340-638 21 1.6e-25 92.01 SMART 1-280 (280) Show / Hide 
Range on Protein: 340-638
Range on HMM: 1-280/280
Sequence Identity: 21% (72 aa)

FNETNKIGQGGYGSVYYGYFRDQKLAVKRMNMQATKEFLSELKILSRV--HHSNLVFSQALYFQLTPTIIFLLQVQLIGYCTV--------ESLFLVYEF
     |.| | .| || |  . .. ||| ..  | ..|..|..|....  || |.                   |.|.|.||         | |..| |.
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDAREDFMREARIMCKLGGHHPNI-------------------VRLYGVCTQQGRNFMYIEPLMIVMEY

VDNGTLAQHLHSTTRPPLSWSSRIQIAMDAARGLEYIHEHAKPTYIHRDIKSTNILIDKNFHAKVADFGLSKLTETG--------MTSISLTQPTRLVGT
...| | ..|... .  |...  .... ..|.| ||.|..    .||||.   |.|...|...|..|||||.  . .        . . . .. .. .  
MPHGDLKDYLRKHRPK-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLP

FGYMSPEYARYGDVSPFLDVYSFGVVLFEI---------------ISAQEAIVRTQSG-ILSNKDE----QKGLATLFEDVLQDDTNGKERLRDLMDPRL
   |.||  .||  ..  ||.||||...||               .|.||.| . ..|  .   ..                                  
IRWMAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMS-----------------------------

GDNYPLEAAWSLAKLAGACTKENPELRPNMRTVVVAL
   .  ..   . ..   | .|.|| ||......  .
---F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-Un_ck.AA Dicty4 412-528 32 1.8e-25 82.05 In-house 61-187 (277) Show / Hide 
Range on Protein: 412-528
Range on HMM: 61-187/277
Sequence Identity: 32% (42 aa)

VQLIGYCTV---ES--LFLVYEFVDNGTLAQHLHS-----TTRPPLSWSSRIQ---IAMDAARGLEYIHEHAKPTYIHRDIKSTNILIDKNFHAKVADFG
... |.||    ..  .  | |..  |.|.  ||.       . .|.|. ...   .| |||||. . |.   |  ||||.|| |.|.|||. .||.|||
CLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSEQQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFG

LSKLTETGMTSISLTQ-PTRLVGTFGYMSPE
||..  ..   .....  .  .|| ..|.||
LSQYMKKH---EDHKDNQMTACGTPCWMAPE
S_TKc IRAK-Un_ck.AA S_TKc 340-642 19 2.4e-25 91.45 SMART 1-231 (231) Show / Hide 
Range on Protein: 340-642
Range on HMM: 1-231/231
Sequence Identity: 19% (63 aa)

FNETNKIGQGGYGSVYYGYFRD--QKLAVKRMNMQATKEFLSELKILSRVHHSNLVFSQALYFQLTPTIIFLLQVQLIGYCTVESLFLVYEFVDN--GTL
.   .|||.|..|.|| .. ..  .. |.|...    . ...|..||.. || |.|     .                     ..|..| |..|.  |.|
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----EHIRREIQILKK-HHPNIVKLYDVFQD-------------------DHLYMVMEYCDGDLGDL

AQHLHSTTRPP----LSWSSRIQIAMDAARGLEYIHEHAKPTYIHRDIKSTNILIDKNFHAKVADFGLSKLTETGMTSISLTQPTRLVGTFGYMSPEYAR
 .....  |..    ..      ..   ...|||.|.| .   ||||.|  |||.|.  | |..||||...             | ..||  ||.||   
FDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHSH-G--IIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL-

YGDVSP-FLDVYSFGVVLFEIISAQEAIVRTQSGILSNKDEQKGLATLFEDVLQDDTNGKERLRDLMDPRLGDNYPLEAAWSLAK-LAGACTKENPELRP
    ..   |..|.|..|.| ..  .   .              ....|. ..                            . || .   | . .|| ||
--GYGKCKCDWWSCGCILYEMLC-GYPPFP-------------QMQMMFKKIG---------------------------SPEAKDFIRKCLQKDPEKRP

NMRTVVV-----ALMTLM
    .       ...  .
TA-EALQDEWDIKCHPWF
Kinase IRAK-Un_ck.AA Pkinase 412-553 29 6.6e-24 85.62 Pfam 63-207 (293) Show / Hide 
Range on Protein: 412-553
Range on HMM: 63-207/293
Sequence Identity: 29% (45 aa)

VQLIGYC-TVESLFLVYEFVDNG----TLAQHLHSTTRPPL--SWSSRIQIAMDAARGLEYIHEHAKPTYIHRDIKSTNILIDKNFHA----KVADFGLS
|.|.... .  .. .| |....|     |. ...   . ..  |.   . ..   .|||||.|..     ||||.|. |||||.| |     |..||||.
VRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLA

KLTETGMTSISLTQPTRLVGTFGYMSPEYAR-YGDVSPFLDVYSFGVVLFEIIS
|. .      . . .| ..|| .||.||  | . . .|  |..|.|..|.| ..
KQFD----Y-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKVDMWSCGCILYEMLC
Kinase IRAK-Un_ck.AA TK 412-553 15 8.6e-24 75.97 In-house 106-389 (486) Show / Hide 
Range on Protein: 412-553
Range on HMM: 106-389/486
Sequence Identity: 15% (44 aa)

VQLIGYCTVES-------------LFLVYEFVDNGT----LAQHLHSTTRP-------------------------------------------------
|.|.|.|| .              . .| |....|     | ..|..  ..                                                 
VRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLI

-------------------------PLSWSSRIQIAMDAARGLEYIHEH----AKPTYIHRDIKSTNILIDKNFH-----------AKVADFGLSKLTET
                         .|.   .. .....|.|.||.|..      . ..|||.   |.|...| .           .|.||||||. .. 
KDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGS-

GMTSISLTQ--PTRLVGTFG----------------------------YMSPEYAR---------YGDVSPFLDVYSFGVVLFEIIS
|. .  . .    . ... |                            .|.||  .         ||  ..  ||.||||...|| .
GVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-Un_ck.AA Pkinase_Tyr 412-502 30 1.1e-20 70.69 Pfam 67-160 (270) Show / Hide 
Range on Protein: 412-502
Range on HMM: 67-160/270
Sequence Identity: 30% (30 aa)

VQLIGYCT-V-ES--LFLVYEFVDNGTLAQHLHST--TRPPLSWSSRIQIAMDAARGLEYIHEHAKPTYIHRDIKSTNILIDKNFHAKVADFGLSKL
|.|.| ||   |.  ...| |.. .| |  .|..    ..||. .  .|.... |.|.|| ...    .||||.   |.|...|...|..||||...
VRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARD
Kinase IRAK-Un_ck.AA STE 412-552 23 2.3e-20 68.7 In-house 93-262 (359) Show / Hide 
Range on Protein: 412-552
Range on HMM: 93-262/359
Sequence Identity: 23% (42 aa)

VQLIGYCTVE--------SLFLVYEFVDNGTLAQHLHS--TTRPPLS----------WSSRIQIAMDAARG-LEYIHEHAKPTYIHRDIKSTNILIDKNF
|. .|.. .|        .|... |..|.|.| . ...   .  ||.           |  . |. .  .| |.|.|.|    .||||||. |||.    
VKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL----

HAKVADFGLSK-LTETGMTSISLT------------QPTRLVGTFGYMSPEYARY------GDVSPFLDVYSFGVVLFEII
 .| .|||... ||...  . . .            . . .|||  .|.||  .       .. .   |..|.| .. | .
-VKLCDFGVCGQLTDSMANI-Q-SNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMA
Kinase IRAK-Un_ck.AA IRAK 340-393 33 3.8e-12 39.48 In-house 1-66 (317) Show / Hide 
Range on Protein: 340-393
Range on HMM: 1-66/317
Sequence Identity: 33% (22 aa)

FNETNKIGQGGYGSVYYGYFRDQK--LAVKRMNMQAT-------KEFLS---ELKILSRVHHSNLV
|.. |.||.||.| || | .. .    |||.    |        ..|..   |||...| .| |.|
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIV
Kinase IRAK-Un_ck.AA TKL-Unique 343-393 36 5e-11 35.31 In-house 2-59 (290) Show / Hide 
Range on Protein: 343-393
Range on HMM: 2-59/290
Sequence Identity: 36% (21 aa)

TNKIGQGGYGSVYYGYFRDQKLAVKRMNM------QATKEFLSELKILSRVH-HSNLV
 ||||.||||.|| | .|  . |.|. .       . ..|| .|...... | | |.|
WNKIGEGGYGQVYKGKWRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIV
Kinase IRAK-Un_ck.AA STE 340-393 19 9.2e-11 34.35 In-house 1-93 (359) Show / Hide 
Range on Protein: 340-393
Range on HMM: 1-93/359
Sequence Identity: 19% (18 aa)

FNETNKIGQGGYGSVYYGYFRDQK-----------------LAVKRMNMQATK--------------------EFLSELKILSRVH--HSNLV
.    |||.|..|.||... ...                   |.|.||..  .                    ..| |.||... .  | | |
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIV
Kinase IRAK-Un_ck.AA TKL 346-393 20 1.6e-10 34.08 In-house 1-88 (364) Show / Hide 
Range on Protein: 346-393
Range on HMM: 1-88/364
Sequence Identity: 20% (18 aa)

IGQGGYGSVYYGYFRD----------QKLAVKRMNMQ------------------------------ATKEFLSELKILSRVHHSNLV
||.||.| || |..|           .  |||.....                              . ...  |....|| .| |.|
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIV
Kinase IRAK-Un_ck.AA MLK 340-394 22 9.7e-10 30.09 In-house 1-74 (291) Show / Hide 
Range on Protein: 340-394
Range on HMM: 1-74/291
Sequence Identity: 22% (17 aa)

FNETNKIGQGGYGSVYYGYFRDQK-----LAVKRMNMQA---------TKEFLSELKILSRVHHSN-----LVF
...  .|| |..|.|. |..| .      .|||| .  .          ..|  | ..|... | |      .|
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQF
Kinase IRAK-Un_ck.AA Pkinase_Tyr 340-393 29 5.8e-09 30.98 Pfam 1-67 (270) Show / Hide 
Range on Protein: 340-393
Range on HMM: 1-67/270
Sequence Identity: 29% (20 aa)

FNETNKIGQGGYGSVYYGYFR------DQKLAVKRMNMQATKE------FLSELKILSRV-HHSNLV
     |.|.| .|.|| |. .      ... ||| .. .|..|      |..|.||..   || |.|
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIV
Kinase IRAK-Un_ck.AA Dicty4 340-382 32 2.6e-07 20.62 In-house 1-46 (277) Show / Hide 
Range on Protein: 340-382
Range on HMM: 1-46/277
Sequence Identity: 32% (15 aa)

FNETNKIGQGGYGSVYYGYFRDQKLAVKRM---NMQATKEFLSELK
 | ...||.|..|.|| |  | .. ||| .   |  .  ..|.|..
INIEQRIGKGSFGEVYKGTWRGKEVAVKKLNNHNQNFDENMLNEFR
Kinase IRAK-Un_ck.AA LRRK 340-393 17 5e-06 17.23 In-house 1-120 (351) Show / Hide 
Range on Protein: 340-393
Range on HMM: 1-120/351
Sequence Identity: 17% (21 aa)

FNETNKIGQGGYG-SVYYGYFRD----------------------------QKLAVKRMNM-------------------------------------QA
. . ..||.||.| .|| . .|.                            |. |.| .|.                                      |
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

TKEFLSELKILSRVHHSNLV
  ||  |. |.|. .|.|.|
FREFRHEVWIMSHLNHPNIV
Kinase IRAK-Un_ck.AA TK 340-393 17 1.5e-05 13.75 In-house 1-106 (486) Show / Hide 
Range on Protein: 340-393
Range on HMM: 1-106/486
Sequence Identity: 17% (19 aa)

FNETNKIGQGGYG---SVYYGYFRD---------------------------QKLAVKRMN----MQATKEFL----------------SELKILS--RV
    .|.|.| .|    || |  |.                           .. ||| .     |... .|.                .|.|...    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHSNLV
|| |.|
HHPNIV
Kinase IRAK-Un_ck.AA Pkinase 340-393 28 4.3e-05 19.1 Pfam 1-63 (293) Show / Hide 
Range on Protein: 340-393
Range on HMM: 1-63/293
Sequence Identity: 28% (18 aa)

FNETNKIGQGGYGSVYYGYFRDQK--LAVKRMNMQATKEFL-------SELKILSRVHHSNLV
.    |||.|..|.|| .. ..     |||... . .|.         ||..|. |..| | |
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIV
Kinase IRAK-Un_ck.AA TK 620-638 31 0.001716 6.72 In-house 468-486 (486) Show / Hide 
Range on Protein: 620-638
Range on HMM: 468-486/486
Sequence Identity: 31% (6 aa)

CTKENPELRPNMRTVVVAL
| ...|| ||...... .|
CWHYDPEDRPTFSQLHEQL
Kinase IRAK-Un_ck.AA Dicty4 540-551 83 0.002186 7.35 In-house 199-210 (277) Show / Hide 
Range on Protein: 540-551
Range on HMM: 199-210/277
Sequence Identity: 83% (10 aa)

DVYSFGVVLFEI
|||||| ||.||
DVYSFGIVLWEI
Kinase IRAK-Un_ck.AA Pkinase_Tyr 540-553 57 0.00803 10.18 Pfam 196-209 (270) Show / Hide 
Range on Protein: 540-553
Range on HMM: 196-209/270
Sequence Identity: 57% (8 aa)

DVYSFGVVLFEIIS
||.||||...||..
DVWSFGVLMWEIFT
Kinase IRAK-Un_ck.AA LISK 345-360 50 0.022869 3.27 In-house 1-16 (296) Show / Hide 
Range on Protein: 345-360
Range on HMM: 1-16/296
Sequence Identity: 50% (8 aa)

KIGQGGYGSVYYGYFR
.||.|..|.|| |. |
EIGKGFFGKVYKGTHR
Kinase IRAK-Un_ck.AA MLK 612-638 33 0.035411 3.51 In-house 265-291 (291) Show / Hide 
Range on Protein: 612-638
Range on HMM: 265-291/291
Sequence Identity: 33% (9 aa)

SLAKLAGACTKENPELRPNMRTVVVAL
...||   | ...|. ||..| .|  |
HWKKLMKQCWNQDPHKRPSFRQIVQHL
Kinase IRAK-Un_ck.AA TKL-Unique 619-638 25 0.099136 2.1 In-house 271-290 (290) Show / Hide 
Range on Protein: 619-638
Range on HMM: 271-290/290
Sequence Identity: 25% (5 aa)

ACTKENPELRPNMRTVVVAL
.| . .|. ||.  ...  |
QCWHHDPSQRPSFDEIIHRL
Kinase IRAK-Un_ck.AA LRRK 620-640 28 0.152344 1.21 In-house 331-351 (351) Show / Hide 
Range on Protein: 620-640
Range on HMM: 331-351/351
Sequence Identity: 28% (6 aa)

CTKENPELRPNMRTVVVALMT
| ...|. || . ..|  | .
CWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-Un_ck.AA Pkinase_Tyr 622-638 29 2.005707 2.06 Pfam 254-270 (270) Show / Hide 
Range on Protein: 622-638
Range on HMM: 254-270/270
Sequence Identity: 29% (5 aa)

KENPELRPNMRTVVVAL
...|| || .. ..  |
HYDPEDRPTFSEIHEQL