Gene IRAK-Un_cn (S.moellendorffii)

IRAK-Un_cn

Species: S.moellendorffii
Alias: IRAK-Un_cn
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_cn.AA Protein None 415 None Fasta, JSON
IRAK-Un_cn.NA RNA None 1248 None Fasta, JSON
IRAK-Un_cn.kin_dom Protein Kinase Domain None 126 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_cn.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_cn.AA TKL 175-330 16 9.1e-26 89.77 In-house 7-286 (364) Show / Hide 
Range on Protein: 175-330
Range on HMM: 7-286/364
Sequence Identity: 16% (48 aa)

GNVFRGTLQD---------GRVVVIKK------------------------------------KVSELELDILLRIRSASIVNLVGFSSDAQQ-------
| |..|...          |..|..||                                    .  | |. ...|.|   || ..|.. . ..       
GEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHP

------KCLVFDYMHLGR-LSRRLFDDTLPPISWGNRLRIALQISRAVEYLHTYA-----EPHIVHLNISAENVLLDGSWN--------------AKLSG
       |.| .|.. |  |.. .         |  |.|.||.|.|...|||.        | |.| ..  .|.|.|  |.              .|.. 
VGPWGQLCIVMEYCPGGSLLHYLH---------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICD

FGRAQSSS----------------------------V---------AIKPALKLQ------------------DVYSFGSLVLELVTGK
|| ... |                            .         ... .....                  |||||| .  |..|..
FGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRC
Kinase IRAK-Un_cn.AA IRAK 198-298 32 1.2e-17 59.26 In-house 53-158 (317) Show / Hide 
Range on Protein: 198-298
Range on HMM: 53-158/317
Sequence Identity: 32% (35 aa)

ELDILLRIRSASIVNLVGFSSDAQQKCLVFDYMHLG----RLSRRLFDDTLPPISWGNRLRIALQISRAVEYLHTYAEPH--IVHLNISAENVLLDGSWN
|| ...|.| . || | |.... |. |||..||  |    ||. .  .....| ||  |. |.. .......||. ..|   | | .|.  |.|||   .
ELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQ-NHPCTPIIHGDIKSANILLDQHFT

AKLSGFG
.|.. ||
PKICDFG
Kinase IRAK-Un_cn.AA TKL-Unique 198-298 22 2.3e-16 54.37 In-house 45-162 (290) Show / Hide 
Range on Protein: 198-298
Range on HMM: 45-162/290
Sequence Identity: 22% (27 aa)

ELDILLRIR-SASIVNLVGFSS----DAQQKCLVFDYMHLGRLSRRLFD--------DTLPPISWGNRLRIALQISRAVEYLHTYAEPHIVHLNISAENV
|. .. ... .. || ..|..     .. . |.| .|. .| |   | .            .... .|...|..|... .|||..  | | |...   |.
EVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNF

LLDGS-----WNAKLSGFG
|.|       ||.|...||
LVDNNSNIAEWNIKICDFG
Kinase IRAK-Un_cn.AA LRRK 209-303 31 1.1e-10 34.06 In-house 118-230 (351) Show / Hide 
Range on Protein: 209-303
Range on HMM: 118-230/351
Sequence Identity: 31% (36 aa)

SIVNLVGFSSDAQQKCLVFDYMHLGRLSRRLF---DDTL----PPISWGNRLRIALQISRAVEYLHTYAEPHIVHLNISAENVLLDGS------------
.||.|.||. .    |.| .|. .| |...|.    | .    . |||. .|.|||||....||||  . | |.| .   .|.|| .|            
NIVSLKGFCIHPL--CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLKSPNILLWSSPQNHSPNYPNAH

WNAKLSGFGRAQ--SS
 .||.. ||  .  ..
VCAKIADFGISRMFQC
Kinase IRAK-Un_cn.AA TK 175-300 12 2.1e-10 30.29 In-house 13-306 (486) Show / Hide 
Range on Protein: 175-300
Range on HMM: 13-306/486
Sequence Identity: 12% (37 aa)

G---NVFRGTLQDG---------------------------RVVVIKKK----VSEL------------------ELDILLRIR-----SASIVNLVG--
|    |..|.....                           .| |  .|     |.                   |. ..   .        ||.|.|  
GSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVC

-----------FSSDAQQKCLVFDYMHLGR--------LSRR--------------------------------------------------LFDDTLPP
           . .. .  ..|  ||..|         | ..                                                  |..| .||
TQGEPKPCFEVV-VHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPP

ISWGNRLR-------------------IALQISRAVEYLHTY----AEPHIVHLNISAENVLLDGSWN-----------AKLSGFG--------RA
..    |.                   ...||... ||||        ...|| .. | |.|.. . .           .|.. ||        .|
LTTKDLLQMAWQWCLTCKHQLTMHQLLMCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSRQGSGVLA
Kinase IRAK-Un_cn.AA MLK 175-298 19 5.4e-10 31.0 In-house 13-178 (291) Show / Hide 
Range on Protein: 175-298
Range on HMM: 13-178/291
Sequence Identity: 19% (32 aa)

GNVFRGTLQDGR----VVVIKK---------------KVSELELDILLRIRSAS----IVNLVGFSSDAQQ-KCLVFDYMHLGRLSRRLFD-DTLPP---
| |..|. .  .    .| .|.               .  | |  .| ...       |. ..| ... ..  |.|  |.  | |.. | . .. .    
GKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDAN

--------ISWGNRLRIALQISRAVEYLHTYAEPHIVHLNISAENVLLD------GSWNAKLSGFG
        .. .  ...|||..|...|||  | . |.|  .   |.|.|      .  ..| . ||
HNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFG
TyrKc IRAK-Un_cn.AA TyrKc 169-391 17 6e-10 -61.76 SMART 1-280 (280) Show / Hide 
Range on Protein: 169-391
Range on HMM: 1-280/280
Sequence Identity: 17% (51 aa)

VVSDSD------GNVFRGTLQDGRVVVIKKKVSEL------ELDILLRI--RSASIVNLVGFSSDA-------QQKCLVFDYMHLGRLSRRLFDDTLPPI
.. .        | |..||.   . | .|.  ..       |. |. ..  .   ||.|.|  ..        .. ..|. || .| |  .| .     .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK-L

SWGNRLRIALQISRAVEYLHTYAEPHIVHLNISAENVLLDGSWNAKLSGFG--RAQSSS-------VAIKP----ALK--------------LQ------
..   | ...||..  ||||     ...|  . | |.|..    .| | ||  |.  .          ...      |                      
CMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKS

DVYSFGSLVLELVT-GKASSDR-----KHKREALAAIEAGMGHTIMDKRLENENQI------AKMGEIAAWC-MSDSTRQPSMVEVSSTL
||.||| .  |. | |.          .  .|... ...|.   ...  .     .      ..| .|  .| . |    |.. |. . .
DVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY---P-MSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-Un_cn.AA UTK 209-298 25 8.5e-10 29.7 In-house 71-170 (296) Show / Hide 
Range on Protein: 209-298
Range on HMM: 71-170/296
Sequence Identity: 25% (26 aa)

SIVNLVGFSSDAQQKCLVFDYMHLGRLSR---RLFDDTLPPISWGN---RLRIALQISRAVEYLHTYAEPHIVHLNISAENVLLDGS-------WNAKLS
....|||  .. .. ..|  ||  | |.    |  ... ..  | .   ||  |..|.|...|||   . ..|| .. | |.|.. .       . .|..
NVLRLVGVCTQEEPWMIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLH---SCGFVHRDLAARNCLVHMHRMMWHCMMVCKIA

GFG
.||
DFG
Kinase IRAK-Un_cn.AA DRK 224-298 28 1.1e-08 25.59 In-house 73-145 (258) Show / Hide 
Range on Protein: 224-298
Range on HMM: 73-145/258
Sequence Identity: 28% (21 aa)

CLVFDYMHLGRLSRRLFDDTLPPISWGNRLRIALQISRAVEYLHTYAEPHIVHLNISAENVLLDGSWNAKLSGFG
| .  || .| | . | |. .  ..|. ...... . . . |||   .| |.|      | | | .|  | . ||
CICMEYMPRGSLYNILHDESI-EMDWPLMKQMMFDCAKGMIYLHC-CNPIIIHRDLKSHNLLVDEHWQVKVADFG
Kinase IRAK-Un_cn.AA S_TKc 175-415 16 1.2e-08 -49.97 SMART 13-220 (231) Show / Hide 
Range on Protein: 175-415
Range on HMM: 13-220/231
Sequence Identity: 16% (45 aa)

GNVFRGTLQD-GRVVVIKK--KVSELELDILLRIRSASIVNLVGFSSDAQQKCLVFDYMHL--GRLSRRLFDDTLPP----ISWGNRLRIALQISRAVEY
| |....  . ||.| ||.  .  . |..|| . .   ||.| ..  | .  ..|..|.    | | ... .   ..    ..     ... || .|.||
GKVYKCRHKKTGRIVAIKIIKEHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEY

LHTYAEPHIVHLNISAENVLLDGSWNAKLSGFG--RAQSSSVA----------IKPALK-LQDVYSFGSLVLELVTGKASSDRKHKREALAAIEAGMGHT
.|   . .|.|  .  ||.|||   . |.. ||  |   ...           . .  |   |..|.| .. |...|.   .     .  . ..  .   
CH---SHGIIHRDLKPENILLDE--HIKICDFGLARQL-TTFCGTPWYMAPEVL-GYGKCKCDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG---

IMDKRLENENQIAKMGEIAAWCMSDSTRQPSMVEVSSTLSQVTAMVLRSASK---KQRPPPGKSRD
                                       |.     .|   .   ..||   .   
---------------------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQ
Kinase IRAK-Un_cn.AA TK-Unique 253-300 36 2.4e-08 25.0 In-house 134-180 (294) Show / Hide 
Range on Protein: 253-300
Range on HMM: 134-180/294
Sequence Identity: 36% (18 aa)

LRIALQISRAVEYLHT--YAEPHIVHLNISAENVLLDGSWNAKLSGFGRA
...| || .. |||.   .   .||| ...| |||| .  ..|...||.|
YHFAWQIACGMEYLASQRK---KIVHRDLCARNVLLTEDKVCKICDFGMA
Kinase IRAK-Un_cn.AA RIPK 198-298 28 6.3e-08 23.07 In-house 46-154 (290) Show / Hide 
Range on Protein: 198-298
Range on HMM: 46-154/290
Sequence Identity: 28% (31 aa)

ELDILLRIRSASIVNLVGFSSDAQQ------KCLVFDYMHLGRLSRRLFDDTL---PPISWGNRLRIALQISRAVEYLHTYAEPHIVHLNISAENVLLDG
|  .. ..|   || . ||  . ..        .|  ||  | |.  |   .    .|. |  | |.  .||... |||    | | |.    ||.|.|.
EAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFLHTKWPYQHHPDPWPLRCRMIHEISCGMCYLHSMN-PPIIHRDLKPENILVDN

SWNAKLSGFG
  ..|.. ||
NFHVKIADFG
Kinase IRAK-Un_cn.AA Pkinase 197-267 22 2e-06 23.81 Pfam 47-125 (293) Show / Hide 
Range on Protein: 197-267
Range on HMM: 47-125/293
Sequence Identity: 22% (18 aa)

L--ELDILLRIRSASIVNLVGFSSDAQQKCLVFDYMHLG----RLSRRLFDDTLPPI--SWGNRLRIALQISRAVEYLH
.  |. |..|...  || | ..  | .  ..|..|.  |     |....  .   ..  |.    ....|| |..||.|
RLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCH
Kinase IRAK-Un_cn.AA Pkinase_Tyr 210-267 28 0.000956 13.31 Pfam 66-128 (270) Show / Hide 
Range on Protein: 210-267
Range on HMM: 66-128/270
Sequence Identity: 28% (18 aa)

IVNLVGFSSDAQQK---CLVFDYMHLGRLSRRLFDD--TLPPISWGNRLRIALQISRAVEYLH
||.|.|  .| ..    ..|. || .| |   | .     .|..    | ...||... |||.
IVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase IRAK-Un_cn.AA IRAK 315-391 21 0.009985 5.69 In-house 206-317 (317) Show / Hide 
Range on Protein: 315-391
Range on HMM: 206-317/317
Sequence Identity: 21% (24 aa)

DVYSFGSLVLELVTGK--ASSDRKH---KREALAAIEAGMGH---------------------TI------MDKRLENEN--QIAKMGEIAAWCMSDST-
||||||  .||..||   . .|| .   ... .  |.   ||                      .       |.| .  .    ..|   |  |.   . 
DVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCGHHRAN

RQPSMVEVSSTL
| ..| .| ..|
RRCDMAWVMQQL
Kinase IRAK-Un_cn.AA RIPK 315-330 50 0.16061 0.91 In-house 210-225 (290) Show / Hide 
Range on Protein: 315-330
Range on HMM: 210-225/290
Sequence Identity: 50% (8 aa)

DVYSFGSLVLELVTGK
|||||. .. |. |.|
DVYSFAIVMWEVLTQK
Kinase IRAK-Un_cn.AA TKL-Unique 315-330 56 0.290904 0.43 In-house 210-225 (290) Show / Hide 
Range on Protein: 315-330
Range on HMM: 210-225/290
Sequence Identity: 56% (9 aa)

DVYSFGSLVLELVTGK
||||||  . |..|.|
DVYSFGIVLWEIATRK
Kinase IRAK-Un_cn.AA Pkinase 315-350 20 6.112361 0.87 Pfam 194-232 (293) Show / Hide 
Range on Protein: 315-350
Range on HMM: 194-232/293
Sequence Identity: 20% (8 aa)

DVYSFGSLVLELVTGKASSDRK----HKREALAAIEAGMG
|..|.| .. |...|.   . .    . .. .. |.  ||
DMWSCGCILYEMLCGRPPFPGHCWHDN-HDQMQMICRIMG