Gene IRAK-Un_de (S.moellendorffii)

IRAK-Un_de

Species: S.moellendorffii
Alias: IRAK-Un_de
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_de.AA Protein None 397 None Fasta, JSON
IRAK-Un_de.NA RNA None 1194 None Fasta, JSON
IRAK-Un_de.kin_dom Protein Kinase Domain None 265 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_de.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_de.AA TKL 124-384 22 1.5e-69 237.39 In-house 1-364 (364) Show / Hide 
Range on Protein: 124-384
Range on HMM: 1-364/364
Sequence Identity: 22% (84 aa)

VGSGAFGPVYKATPSPSS-------PTRLAVKVLSSTSKQGE---------------------------REFQTEVSLLGRLHHKNLVNLVGYCTDRRE-
.|||.|| |||..    .        .  |||...|.. . .                            ..  |. .. ||.| |.| ..|||.. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RMLVYEYMSNGSLEKLLYNDKREALSWSERVQIAKDVSRGIEYLHDGAV-----PPVIHRDIKSANILLDNSMT--------------
             ..|.||...|||. .|         |. |...|.|..||..|||         ||.||||.||.|||.|. .|              
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH--------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWC

ARVADFGLSKEVSPVVP--------------------TSGIKGTFGYTDPEYI-----FTK-----------VFNEKSDVYSFGVLLFELMSGRHPQHGL
. ..|||||...|.                       |. . ||...  || .     .|.            ..||.||||||..|.|......| ...
CKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRPYYDY

MDYVQMASLGVDEENSDWIELLDSRLNGNCN------------LQELAKLASIAHRCVRKDPETRPPMREIVQWL
. . ....   . .  ...   | .|   .              . .  ..... .|   ||| || . ||...|
PYMPMIFQD--P-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-Un_de.AA IRAK 119-384 28 8.8e-52 178.34 In-house 2-317 (317) Show / Hide 
Range on Protein: 119-384
Range on HMM: 2-317/317
Sequence Identity: 28% (93 aa)

NFTTLVGSGAFGPVYKATPSPSSPTR--LAVK----VLSSTSKQGEREFQT---EVSLLGRLHHKNLVNLVGYCTDRRERMLVYEYMSNGSLEKLLYNDK
.   . |.|.|| ||..     . |    |||    . ... .. ...||.   |. .. |..|.|.| | ||||.| .  |||.||.|||||  |   .
HKDNRIGEGGFGCVYRGQ---WKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQD

-REA---LSWSERVQIAKDVSRGIEYLHDGA-VPPVIHRDIKSANILLDNSMTARVADFGLSK--------EVSPV--VPTSGIKGTFGYTDPEYIF--T
   .   |||  |. |.   ..||..||.     |.||.||||||||||  .|.  .||||          | ...    || ..||  |  ||.|   .
GQCPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQ

KVFNEKSDVYSFGVLLFELMSGR------HPQ-HGLMDYVQMASLGVDEENS------------------------DWIELLDSRLNGNCNLQELAKLAS
.    |.||||||. | |. .|.      .|   .|.|...      .|...                        .   ..|.| .. |. .. .....
GQLTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIM---EEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPP-CPPNMEKEMCQ

IAHRCVRKDPETRPPMREIVQWL
 | .|.      |..|.. .| |
CACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-Un_de.AA TK 118-384 15 6.9e-51 168.42 In-house 1-486 (486) Show / Hide 
Range on Protein: 118-384
Range on HMM: 1-486/486
Sequence Identity: 15% (78 aa)

KNFTTLVGSGAFG---PVYKATPSPSSP------------------------TRLAVKVLSSTSKQGEREFQT-----------------EVSLLG--RL
  .    |.|.||    |||..  . .|                        |. |||.| ... . ..||.                  | ...    .
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

HHKNLVNLVGYCTDRRE------------RMLVYEYMSNGS----LEKLLYNDK----------------------------------------------
||.|.|.|.|.||. ..             |.| |||..|.    | . | . .                                              
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------------------------REALSWSERVQIAKDVSRGIEYLHDGAV---PPVIHRDIKSANILLDNSMT-----------ARVADFGLSK
                            .. |.  ... .. ....| ||||.  .   . ..|||.   |.|......           ...||||||.
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

E----VSPVVPTSGIKGTFG-------------------------------YTDPEYIFTKV---------FNEKSDVYSFGVLLFELMS-GRHPQHGLM
.     .  .. ..   . .                               .. || ....|         | .||||.|||||..|... |. | .| |
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFTYGQEPYYGGM

DYVQMASLGVDEENSDWIELLDS--------------RLNGNCNLQEL--------------AKLASIAHRCVRKDPETRPPMREIVQWL
.  . ..   . .| . .|.| .              |.   .  .                . .. .  .| ..||| || ...... |
SNQDVWKD--G-DNQEVMEYLRRGGRLCRSGLNEVGYRMRMPQPPHCPDWMRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-Un_de.AA Dicty4 119-311 33 8.8e-48 157.53 In-house 2-210 (277) Show / Hide 
Range on Protein: 119-311
Range on HMM: 2-210/277
Sequence Identity: 33% (71 aa)

NFTTLVGSGAFGPVYKATPSPSSPTRLAVKVLSSTSKQG--ER---EFQTEVSLLGRLHHKNLVNLVGYCT----DRRERMLVYEYMSNGSLEKLLYN--
|.. . |.|.|| |||.|      .  |||.| .. .|.  |    ||  ||.... . | |.. . |.||       . . | |||. |.|..|| .  
NIEQRIGKGSFGEVYKGT---WRGKEVAVKKLNNH-NQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKP

---DKREALSWSERVQ---IAKDVSRGIEYLHDGAVPPVIHRDIKSANILLDNSMTARVADFGLSK---EVSPVVP-TSGIKGTFGYTDPEYIFTKVFNE
    ..  |.|. . .   .|.|. ||. .|| .  | .||||.||.|.| | .... |.|||||.   ...     ... .|| ... ||    . .||
SEQQQSIKLDWPLIKRAMRMAFDAARGMNWLH-CCNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNE

KSDVYSFGVLLFEL
|.|||||| .|.|.
KADVYSFGIVLWEI
Kinase IRAK-Un_de.AA LRRK 118-317 26 1.7e-47 164.14 In-house 1-282 (351) Show / Hide 
Range on Protein: 118-317
Range on HMM: 1-282/351
Sequence Identity: 26% (76 aa)

KNFTTLVGSGAFG-PVYKATPSP-------------------------SSPTRLAVKVLSST---------------------SKQGE------------
  .  ..|.|.|| .||.|.                             . .  |.|..  .                     | |.|            
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

-REFQTEVSLLGRLHHKNLVNLVGYCTDRRERMLVYEYMSNGSLEKLLYNDKREA-------LSWSERVQIAKDVSRGIEYLHDGAVPPVIHRDIKSANI
 |||. ||... .|.| |.|.|.|.|   . ...| ||...|.| ..| | |. .       .||. . .|| ....|.||||. . ||.|||| || ||
FREFRHEVWIMSHLNHPNIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHS-HNPPIIHRDLKSPNI

LL---D---------NSMTARVADFGLSK--EVSPVVPTSGIKGTFGYTDPEYIF---TKVFNEKSDVYSFGVLLFELMSGR-HP
||   .         . ..| .||||.|    . .   ..|  |..|.  || .    .....||.|.||||..|.||.... ||
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQHHP
Kinase IRAK-Un_de.AA Pkinase_Tyr 119-317 31 1.7e-46 158.12 Pfam 2-214 (270) Show / Hide 
Range on Protein: 119-317
Range on HMM: 2-214/270
Sequence Identity: 31% (68 aa)

NFTTLVGSGAFGPVYKATPS---PSSPTRLAVKVLSSTSKQGE---REFQTEVSLLGRL-HHKNLVNLVGYCTDRRER---MLVYEYMSNGSLEKLLYND
 |    |.|||| |||.|      .  .  |||.|  .. . .   ..|  |....  | ||.|.|.|.| |||..|    ..| ||| .|.| . | . 
TFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKH

--KREALSWSERVQIAKDVSRGIEYLHDGAVPPVIHRDIKSANILLDNSMTARVADFGLSKEV-----SPVVPTSGIKGTFGYTDPEYIFTKVFNEKSDV
   ...|. .. .|.. ....| |||..      ||||.   |.|..........||||.. .       .. ..| |     . || |....|..||||
REDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYY-YRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGVLLFELMS-GRHP
.|||||..|... |. |
WSFGVLMWEIFTYGEQP
Kinase IRAK-Un_de.AA TKL-Unique 120-321 30 2.1e-46 160.46 In-house 1-237 (290) Show / Hide 
Range on Protein: 120-321
Range on HMM: 1-237/290
Sequence Identity: 30% (74 aa)

FTTLVGSGAFGPVYKATPSPSSPTRLAVKVLSS---TSKQGEREFQTEVSLLGRLH-HKNLVNLVGYCT----DRRERMLVYEYMSNGSLEKLLY-----
|  ..|.|..|.|||..   ..    |.|...     |.. ..||  ||... .|| |.|.| ..|||.    .  .. .| ||.. ||| ..|      
FWNKIGEGGYGQVYKGKWRGYP---VAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNN

---NDKREALSWSERVQIAKDVSRGIEYLHDGAVPPVIHRDIKSANILLDNS-----MTARVADFGLSKEVSPVVPTSGI----------KGTFGYTDPE
   | .   |... ||..|.|...| .|||    | .||||.|| |.|.||      . ....||||||  |    .. .          .|.| .  ||
NNNNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPE

YIFT--KVFNEKSDVYSFGVLLFELMSGRH------PQHGL
 .    . ..|||||||||. | |. ..        | .|.
VLRMNFCQYSEKSDVYSFGIVLWEIATRKITKTYKKPYQGM
Kinase IRAK-Un_de.AA TyrKc 118-384 26 2.6e-45 157.75 SMART 1-280 (280) Show / Hide 
Range on Protein: 118-384
Range on HMM: 1-280/280
Sequence Identity: 26% (79 aa)

KNFTTLVGSGAFGPVYKATPSPSSPTRLAVKVLSSTSKQGEREFQTEVSLLGRL--HHKNLVNLVGYCTDR-------RERMLVYEYMSNGSLEKLLYND
  .    |.|||| |||.| .    .  |||.| . .   ...|  | ... .|  ||.|.|.|.|.||.           |.| |||..|.| . | . 
ITLGKKLGEGAFGEVYKGTWK----IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKH

KREALSWSERVQIAKDVSRGIEYLHDGAVPPVIHRDIKSANILLDNSMTARVADFGLSKEVSPV--------VPTS----GIK--GTFGYTDPEYIFTKV
... |.... .... ....| ||||.    ..||||.   |.|...  |....|||||...           . ..    | |       . || |....
RPK-LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

FNEKSDVYSFGVLLFELMS-GRHPQHGL----MDYVQMASLGVDEENSDWIELL----DSRLNGNCNLQELAKLASIAHRCVRKDPETRPPMREIVQWL
|..||||.||||...|... |  |  |     |.  ..  . |.. .   .        .           ... .|  .| . ||| || ..||.. .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEY-VKQGYRMPQPPNDYPMSF-------VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAK-Un_de.AA MLK 118-317 27 4.2e-45 154.42 In-house 1-235 (291) Show / Hide 
Range on Protein: 118-317
Range on HMM: 1-235/291
Sequence Identity: 27% (66 aa)

KNFTTLVGSGAFGPVYKATPSPSSPTR-----LAVKVLS------STSKQGEREFQTEVSLLGRLHHKN----LVNLVGYCTDR-RERMLVYEYMSNGSL
 .| . .|||.|| |.|..      ..     .|||         | .    ..|..|. .| .| |.|     . ..| |..   .  .| ||...|||
IQFHEWIGSGSFGKVWKGR---WRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSL

EKLLYN-DKREA-----------LSWSERVQIAKDVSRGIEYLHDGAVPPVIHRDIKSANILLDN------SMTARVADFGLSKEVSPVVPT--SGIKGT
  .|.. .. ..            . .  ...|....||..|||  |..|.||||.|| |||.|.       .|....|||.|....    |   . .||
YNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMC-TNMMSNAGT

FGYTDPEYI---FTKVFNEKSDVYSFGVLLFELMSGRHP
. .  || |       ..||.||.|.||.| |......|
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTREVP
Kinase IRAK-Un_de.AA Pkinase 118-317 28 4e-42 150.01 Pfam 1-211 (293) Show / Hide 
Range on Protein: 118-317
Range on HMM: 1-211/293
Sequence Identity: 28% (63 aa)

KNFTTLVGSGAFGPVYKATPSPSSPTRLAVKVLSSTSKQGEREFQT-----EVSLLGRLHHKNLVNLVGYCTDRRERMLVYEYMSNG----SLEKLLYND
  .   .|||.|| |||..   ... . |||...   .. . . ||     |.... ||.|.| | | ....|...  .| ||. .|    .|  ..  .
YHIGRKIGSGSFGCVYKCH-HKGTGKIVAVKIIKKR-HEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTW

KREAL--SWSERVQIAKDVSRGIEYLHDGAVPPVIHRDIKSANILLDNSMTA----RVADFGLSKE--VSPVVPTSGIKGTFGYTDPEYIF-TKVFNEKS
.. ..  |. |   ... . ||.||.|.     .||||.|..|||.|| ..     ...||||.|     . . .... || .|  || |   .    |.
RHGCFYFSEWECKFYMYQILRGLEYCHS-M--GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS-MTTFCGTPWYMAPEVIRGGQYYGPKV

DVYSFGVLLFELMSGRHP
|..|.|..|.|...|| |
DMWSCGCILYEMLCGRPP
Kinase IRAK-Un_de.AA S_TKc 118-384 22 5.6e-41 143.37 SMART 1-231 (231) Show / Hide 
Range on Protein: 118-384
Range on HMM: 1-231/231
Sequence Identity: 22% (65 aa)

KNFTTLVGSGAFGPVYKATPSPSSPTRLAVKVLSSTSKQGEREFQTEVSLLGRLHHKNLVNLVGYCTDRRERMLVYEYMSN--GSLEKLLYNDKREA---
  .  ..|.|||| |||..    .  . |.|...       . .. |...| . ||.|.|.| ... |  .  .| ||...  |.| ... . .|.    
YEILRKIGKGAFGKVYKCRHKK-TGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRF

-LSWSERVQIAKDVSRGIEYLHDGAVPPVIHRDIKSANILLDNSMTARVADFGLSKEVSPVVPTSGIKGTFGYTDPEYIFTKVFNE-KSDVYSFGVLLFE
 ..  .   ... . ...||.|.     .||||.| .|||||.  .  ..||||....      . . ||  |  || .    ..  |.|..|.|..|.|
PFPE-HARFYMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQL------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILYE

LMSGRHPQHGLMDYVQMASLGVDEENSDWIELLDSRLNGNCNLQELAKLASIAHRCVRKDPETRPPMREIVQ---------WL
...|. | .   .. .|  . .                          . ..  .| .|||| ||   |. |         |.
MLCGYPPFP---QMQMMFKKIG-----------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-Un_de.AA RIPK 124-317 28 2e-39 132.03 In-house 1-227 (290) Show / Hide 
Range on Protein: 124-317
Range on HMM: 1-227/290
Sequence Identity: 28% (67 aa)

VGSGAFGPVYKATPSPSSPTRLAVKVLSSTS------KQGEREFQTEVSLLGRLHHKNLVNLVGYCTDR-----RE-RMLVYEYMSNGSLEKLLYNDKRE
||.|.|| |.||.   .  ...|.|.  .        .| . .   |.  . .| ... | . | | .       .   .| ||| ||||...|   ...
VGGGGFGEVFKARHR-HWGDWVAKKCKPCKHCHTHMDDQERMYQKEEAKHMHKLRCEHIVPIYGFCQCEEWDCDCKLYGIVMEYMENGSLWHFL---HTK

A------LSWSERVQIAKDVSRGIEYLHDGAVPPVIHRDIKSANILLDNSMTARVADFGLSK--EVSPVVP-----------TSGIK-GTFGYTDPEYIF
       . |. |  . . .|.|  |||.   ||.|||| | .|||.|| . . .|||||..  . | .             .|  . ||  | .|| ..
WPYQHHPDPWPLRCRMIHEISCGMCYLHSMN-PPIIHRDLKPENILVDNNFHVKIADFGLATWMMWSHSHQDRCNQREVYSMKSKNRWGTLSYMPPEHFR

------TKVFNEKSDVYSFGVLLFELMSGRHP
      .||...|.|||||.....|.....||
TDNKKPIKVVTPKYDVYSFAIVMWEVLTQKHP
Kinase IRAK-Un_de.AA Dicty4-Unclassified 146-317 31 7.6e-36 120.22 In-house 26-207 (263) Show / Hide 
Range on Protein: 146-317
Range on HMM: 26-207/263
Sequence Identity: 31% (58 aa)

AVKVLSSTSKQGE----REFQTEVSLLGRLHHKNLVNLVGYCTDR----RERMLVYEYMSNGSLEKLLY---NDKREALSWSE--RVQIAKDVSRGIEYL
||| . . . .       .|  || .|| . | ||| . |||          . | | |  | |  .      ..   ..  .   . .| |. .|. .|
AVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQGMQHL

HDGAVPPVIHRDIKSANILLDNSMTARVADFGLSKEVSPVVPTSGIKGTFGYTDPEYIFTKVFNEKSDVYSFGVLLFELMSGRHP
|      .|||||||.|||.|    ...||||.| ...       | ||   . ||      .| ||||||....|.||. |  |
HTRN---FIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNMTTIAGTPKWESPECLMHESYNQKSDVYSYAMMLYELATGDEP
Kinase IRAK-Un_de.AA UTK 119-314 27 1.3e-35 119.34 In-house 2-236 (296) Show / Hide 
Range on Protein: 119-314
Range on HMM: 2-236/296
Sequence Identity: 27% (66 aa)

NFTTLVGSGAFGPVYKATPSPSS---PT-RLAVKVLSSTSK--QGER---EFQTEVS---LLGRLH-HKNLVNLVGYCTDRRERMLVYEYMSNGSLEKLL
 .  . |.|||| |.||.  . |   .. . ||||......  | ..   .|  |     .....| | |...|||.||.    |.|.|||.||.| ..|
QLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEPWMIVTEYMENGDLRSYL

YNDKR------EALSWSERVQIAKDVSRGIEYLHDGAVPPVIHRDIKSANILLDNS-------MTARVADFG---LSKEVS------------PVVPTSG
 . ..      ..|.  .|.. | |..|| .|||      ..|||.   |.|.. .       |....||||   .|..|.             . ... 
RRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSCG---FVHRDLAARNCLVHMHRMMWHCMMVCKIADFGRGGMSRRVNTFHFSNRYWESYYYMAQHQ

IKGTFGYTDPEYIFTK-VFNEKSDVYSFGVLLFELMSG
 . ..  . || .     | .||||.||||...|....
DRWPIRWMAPEALTHHTRFTTKSDVWSFGVVCWEIWTW
Kinase IRAK-Un_de.AA Dicty4-Unclassified 366-384 47 0.000518 9.59 In-house 245-263 (263) Show / Hide 
Range on Protein: 366-384
Range on HMM: 245-263/263
Sequence Identity: 47% (9 aa)

CVRKDPETRPPMREIVQWL
|   ||  || | .|.| |
CWHNDPNKRPTMNQIIQYL
Kinase IRAK-Un_de.AA MLK 364-384 47 0.000869 9.17 In-house 271-291 (291) Show / Hide 
Range on Protein: 364-384
Range on HMM: 271-291/291
Sequence Identity: 47% (10 aa)

HRCVRKDPETRPPMREIVQWL
..|   ||. || .|.||| |
KQCWNQDPHKRPSFRQIVQHL
Kinase IRAK-Un_de.AA UTK 362-384 39 0.010747 5.05 In-house 274-296 (296) Show / Hide 
Range on Protein: 362-384
Range on HMM: 274-296/296
Sequence Identity: 39% (9 aa)

IAHRCVRKDPETRPPMREIVQWL
. ||| ..||. || ....|| .
LMHRCWHYDPQERPDFEDLVQQM
Kinase IRAK-Un_de.AA Dicty4 365-386 37 0.03217 3.4 In-house 254-277 (277) Show / Hide 
Range on Protein: 365-386
Range on HMM: 254-277/277
Sequence Identity: 37% (9 aa)

RCVRKDPETRPPMREIVQW--LSR
.|  .||. || . ||.|   |  
WCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAK-Un_de.AA RIPK 355-384 26 0.062823 2.32 In-house 261-290 (290) Show / Hide 
Range on Protein: 355-384
Range on HMM: 261-290/290
Sequence Identity: 26% (8 aa)

ELAKLASIAHRCVRKDPETRPPMREIVQWL
..... .   || . ||. ||  .|.  | 
HCEQMIELMQRCWQQDPNDRPCFQECEEWT
Kinase IRAK-Un_de.AA LRRK 366-386 42 0.115611 1.64 In-house 331-351 (351) Show / Hide 
Range on Protein: 366-386
Range on HMM: 331-351/351
Sequence Identity: 42% (9 aa)

CVRKDPETRPPMREIVQWLSR
|   ||. || . .||. || 
CWQHDPKKRPHFSQIVKRLSQ
Kinase IRAK-Un_de.AA TKL-Unique 365-384 40 0.139514 1.57 In-house 271-290 (290) Show / Hide 
Range on Protein: 365-384
Range on HMM: 271-290/290
Sequence Identity: 40% (8 aa)

RCVRKDPETRPPMREIVQWL
.| . ||. ||   ||.  |
QCWHHDPSQRPSFDEIIHRL
Kinase IRAK-Un_de.AA Pkinase_Tyr 365-384 45 0.326539 4.73 Pfam 251-270 (270) Show / Hide 
Range on Protein: 365-384
Range on HMM: 251-270/270
Sequence Identity: 45% (9 aa)

RCVRKDPETRPPMREIVQWL
.| ..||| || ..||.. |
QCWHYDPEDRPTFSEIHEQL