Gene IRAK-Un_bb (S.moellendorffii)

IRAK-Un_bb

Species: S.moellendorffii
Alias: IRAK-Un_bb
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_bb.AA Protein None 153 None Fasta, JSON
IRAK-Un_bb.NA RNA None 462 None Fasta, JSON
IRAK-Un_bb.kin_dom Protein Kinase Domain None 130 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_bb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_bb.AA TKL 4-152 19 1.5e-32 114.46 In-house 11-236 (364) Show / Hide 
Range on Protein: 4-152
Range on HMM: 11-236/364
Sequence Identity: 19% (45 aa)

QGVLKD---------GSEVAVKQLDLHSKQGQ---------------------------REFVNELSIITSIQHKNLAKLRGYCLDRDD-----------
.|...          | .||||..  |. .                              ....|. .. ...| |. .. |||.. ..           
KGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCGCVCMHPVGPW

--RILVYEFLENKS-LDQLLFESATGIFLDWPTRFQIVLGVANGLAYLHE-----GSQKQIIHRDIKASNILLDHKLH--------------PKISDFEI
    .|.|. .. | |..|.          |. |....|..| |..|||      .  ..|||||.| .|||.| ...              .||.|| .
GQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGL

SKLFNQEKG------------------FTSTVIAGT
|. ..|...                   |.  . ||
SRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGT
Kinase IRAK-Un_bb.AA IRAK 9-132 34 1e-29 102.57 In-house 21-157 (317) Show / Hide 
Range on Protein: 9-132
Range on HMM: 21-157/317
Sequence Identity: 34% (47 aa)

DGSE--VAVK----QLDLHSKQGQREFVN---ELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLENKSL-DQLLFESATGIF--LDWPTRFQIVLGVAN
.. .  .|||      |.  ..  ..|     || . ....|.|.  | |||..|..  |||... | || |.|    ...    | |..|. | .| |.
KNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTAC

GLAYLHEGSQK-QIIHRDIKASNILLDHKLHPKISDF
|. .||. . .  |||.||| .|||||  . |||.||
GIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDF
Kinase IRAK-Un_bb.AA Pkinase 8-152 25 2.7e-24 86.96 Pfam 22-174 (293) Show / Hide 
Range on Protein: 8-152
Range on HMM: 22-174/293
Sequence Identity: 25% (40 aa)

KDGSEVAVKQLDLHSKQG--QREFVN--ELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLENK----SLDQLLF-ESATGIFLDWPTRFQIVLGVANGL
..| .||||.......    ... ..  |..|  ...|.|  .|.... |.|.  .| |..|.     .|  ..  .. ... ... .   ... .. ||
GTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGL

AYLHEGSQKQIIHRDIKASNILLDHKLHP----KISDFEISKLF-NQEKGFTSTVIAGT
.|.|.     |||||.| .|||.|.. |.    ||.|| ..|.| .  ..   |...||
EYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGT
Kinase IRAK-Un_bb.AA TKL-Unique 10-141 28 4.5e-24 81.89 In-house 20-170 (290) Show / Hide 
Range on Protein: 10-141
Range on HMM: 20-170/290
Sequence Identity: 28% (43 aa)

GSEVAVKQLDL---HSKQGQREFVNELSIITSIQ-HKNLAKLRGYCL----DRDDRILVYEFLENKSLDQLLF----ES---ATGIFLDWPTRFQIVLGV
|..||.||. .    |..  .|| ||....  .. |.|. .. |||     .  ....| |...  ||. .|      .   .  . |..  | .... .
GYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNNNNNNNCKLNMQQRVKMAIDI

ANGLAYLHEGSQKQIIHRDIKASNILLDHK-----LHPKISDFEISKLFNQE
| |. |||  . . |||||.| ||.|.| .     .  ||.||..||. ...
AQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKI
Kinase IRAK-Un_bb.AA Dicty4-Unclassified 10-152 34 7.2e-22 71.66 In-house 22-171 (263) Show / Hide 
Range on Protein: 10-152
Range on HMM: 22-171/263
Sequence Identity: 34% (53 aa)

GSEVAVKQLDLHSKQGQ----REFVNELSIITSIQHKNLAKLRGYCLDR----DDRILVYEFLENKSLDQLLF----ESATGIFLDWPTRFQIVLGVANG
| .|||| .   . .       .|  |  |  |||| || |..|||.         . | ||.    |  .      |    | ||      . . .| |
GKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQPIKLDDTLIIKYAFDIAQG

LAYLHEGSQKQIIHRDIKASNILLDHKLHPKISDFEISKLFNQEKGFTSTVIAGT
...||    . .||||||.||||.|     || || ||        |. | ||||
MQHLH---TRNFIHRDIKSSNILMDKHFNIKIADFGISRVIDFN--FNMTTIAGT
Pkinase_Tyr IRAK-Un_bb.AA Pkinase_Tyr 3-132 26 2e-21 73.21 Pfam 16-155 (270) Show / Hide 
Range on Protein: 3-132
Range on HMM: 16-155/270
Sequence Identity: 26% (38 aa)

MQGVLK-----DGSEVAVKQL-DLHSKQG--QREFVNELSIITSI-QHKNLAKLRGYCLDRDDR---ILVYEFLENKSLDQLLFES-ATGIFLDWPTRFQ
..|..|     .. .|||| | . ....   ...| .|..| ... .|.|. .| | |.|...    ..| |. .. .|.  | .    .  |. ..  |
YKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQ

IVLGVANGLAYLHEGSQKQIIHRDIKASNILLDHKLHPKISDF
. . .|.|..||..   |..||||. | |.|...... ||.||
MCWQIAKGMEYLES---KNCIHRDLAARNCLVTENNVVKICDF
Kinase IRAK-Un_bb.AA TK 3-132 12 3e-20 63.91 In-house 19-295 (486) Show / Hide 
Range on Protein: 3-132
Range on HMM: 19-295/486
Sequence Identity: 12% (36 aa)

MQGVLKDGS--------------------------EVAVKQLDLHSKQGQREFVN--------------ELSIITSIQ-----HKNLAKLRGYCLDRDD-
..| .....                          .||||.| ... . |.||                |....   .     |.|. .| |.|.. .  
YKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLGHHPNIVRLYGVCTQGEPK

-----------RILVYEFLENKS----LDQLLFESATGIF------------------------------------------------------------
            ..| |. .. .    |.. | ..  . .                                                            
PCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYDDDLIKDHPPPLTTKDLL

-------------LDWPTRFQIVLGVANGLAYLHEGSQK-----QIIHRDIKASNILLDHKLH-----------PKISDF
             |. ...  . . .|.|..|||  |..     ...|||. | |.|......            ||.||
QMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLH--SKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADF
Kinase IRAK-Un_bb.AA MLK 10-140 26 5.5e-20 66.11 In-house 22-185 (291) Show / Hide 
Range on Protein: 10-140
Range on HMM: 22-185/291
Sequence Identity: 26% (43 aa)

GSE-----VAVKQLD---LHSKQG----QREFVNELSIITSIQHKN----LAKLRGYCLDR-DDRILVYEFLENKSLDQLLFESATGIF-----------
. .     ||||. .     .|.     |..|  |  .   ..|.|      ...| ||.   .  .| |..|. ||  .| .  ....           
NKDIVAKIVAVKRVRARIF-DKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNVLHGARSKWMDANHNQKNDRV

LDWPTRFQIVLGVANGLAYLHEGSQKQIIHRDIKASNILLDH------KLHPKISDFEISKLFNQ
 |    ... | .|.|..|||.  .|.|||||.| .|||.|.      ... ||.|| .|. ..|
YDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQ
Kinase IRAK-Un_bb.AA STE 8-152 19 1.1e-18 62.69 In-house 37-226 (359) Show / Hide 
Range on Protein: 8-152
Range on HMM: 37-226/359
Sequence Identity: 19% (39 aa)

KDGSEVAVKQLDLHSKQG-----------------QREFVNELSIITSIQ--HKNLAKLRGYCLD-------RDDRILVYEFLENKSLDQLLFES-ATGI
. |  .|.||..| ...                  . .. .|..|    .  |.|  |  |....       .|.  .. |.... |||... .   .| 
ETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYFKEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGK

----------FLDWPTRFQIVLGVANG-LAYLHEGSQKQIIHRDIKASNILLDHKLHPKISDFEISKLFNQ---------------EKGFTSTVIAGT
          ... .    |.  .  | |.|||.     |||||||..||||      |..|| ... ...                 .  .. ..||
PLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFGVCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGT
Kinase IRAK-Un_bb.AA Jak 10-136 26 1.1e-17 58.89 In-house 37-169 (299) Show / Hide 
Range on Protein: 10-136
Range on HMM: 37-169/299
Sequence Identity: 26% (37 aa)

GSEVAVKQLDLHSKQGQREFVNELSIITSIQHKNLAKLRGYC--LDRDDRILVYEFLENKSLDQLLF----ESATGIFL--DWPTRFQIVLGVANGLAYL
. .|..| ..  ..| ...|  |.||  ...||.. |..| |    .|. ..| |... ..||  |      ..  . .  ||   .|   ....|. ||
KQVVVKKVQHPCHPQHSCDFHREISIMSQWSHKHIVKYHGVCCHWCQDEYCMVMEYWCYGPLDDYLHKVKERHKWCVNHTEDW--KMQFAKQICWGMHYL

HEGSQKQIIHRDIKASNILLDHKLH---PKISDFEISK
..   |..||.|..|.|||.|.. |    ||..|  ..
ED---KRYIHGDVCARNILVDREGHWCCVKIPFFKLMD
Kinase IRAK-Un_bb.AA TK-Unique 13-136 21 3.2e-16 52.52 In-house 33-181 (294) Show / Hide 
Range on Protein: 13-136
Range on HMM: 33-181/294
Sequence Identity: 21% (32 aa)

VAVKQLD-LHSKQGQREFVNELSIITSIQ-HKNLAKLRGYCLDRD-DRILVYEFLENKSLDQLLFESATG-----------------------IFLDWPT
||||.|   .... ...| .|...  ..  |.|. .. |.| . | .  ...|.... .|. .| ... .                        ...  .
VAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCRPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKD

RFQIVLGVANGLAYLHEGSQ--KQIIHRDIKASNILLDHKLHPKISDFEISK
 ...  ..|.|..||.   .  |.|.|||. |.|.|| ...  ||.|| ...
LYHFAWQIACGMEYLA---SQRKKIVHRDLCARNVLLTEDKVCKICDFGMAR
Kinase IRAK-Un_bb.AA LRRK 4-140 20 6.5e-16 52.77 In-house 18-229 (351) Show / Hide 
Range on Protein: 4-140
Range on HMM: 18-229/351
Sequence Identity: 20% (45 aa)

QGVLKD---------------------------GSEVAVKQLDLH----------------------------------SKQGQREFVNELSIITSIQHK
.. ...                           ...||.|.....                                  .    ||| .|..|. . .| 
RAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRAFREFRHEVWIMSHLNHP

NLAKLRGYCLDRDDRILVYEFLENKSLDQLLFESA-TG-----IFLDWPTRFQIVLGVANGLAYLHEGSQK-QIIHRDIKASNILL-DHKLHP-------
|. .| |.|.  . ...| |.. . .|...|.... .|     . ..| .. .|.| .| |..|||  |..  ||||| |  ||||  .. ..       
NIVSLKGFCI--HPLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLH--SHNPPIIHRDLKSPNILLWSSPQNHSPNYPNA

----KISDFEISKLFNQ
    ||.|| || .| |
HVCAKIADFGISRMF-Q
Kinase IRAK-Un_bb.AA TyrKc 3-153 14 7.1e-09 -79.14 SMART 16-280 (280) Show / Hide 
Range on Protein: 3-153
Range on HMM: 16-280/280
Sequence Identity: 14% (41 aa)

MQGVLKDGSEVAVKQLDLHSKQGQREFVNELSIITSI--QHKNLAKLRGYCLDR-------DDRILVYEFLENKSLDQLLFESATGIFLDWPTRFQIVLG
..|..|   .|||| |  ..   ...| .|..| ...  .|.|. .| |.|..        .   .| |. .. .|.. | ..     | ...  .. . 
YKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK--LCMKDLLSFCWQ

VANGLAYLHEGSQKQIIHRDIKASNILLDHKLHPKISDFEISKLFN------------------QEK---------------------------------
.|.| .|||.    ..||||. | |.|...... |||||  |.                     ..|                                 
IACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGKFTTKSDVWSFGVCMWE

----------G-----------------------FTS-------------------------------TVIAGTM
          |                         .                               . |   .
IFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
S_TKc IRAK-Un_bb.AA S_TKc 1-149 16 7.4e-07 -76.39 SMART 1-231 (231) Show / Hide 
Range on Protein: 1-149
Range on HMM: 1-231/231
Sequence Identity: 16% (40 aa)

FAMQGVL--------------KDGSEVAVKQLDLHSKQGQREFVNELSIITSIQHKNLAKLRGYCLDRDDRILVYEFLEN--KSLDQLLFESAT----GI
. .  ..              |.| .||.|...       . . .|..|  . .|.|. || ... | |.  .| |....   .| ... .  .      
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FLDWPTRFQIVLGVANGLAYLHEGSQKQIIHRDIKASNILLDHKLHPKISDF------------------------E-----------------------
|    .|| ..  ....|.|.|.   ..|||||.| .|||||.  | ||.||                                                
FPE-HARF-YMYQICCALEYCHS---HGIIHRDLKPENILLDE--HIKICDFGLARQLTTFCGTPWYMAPEVLGYGKCKCDWWSCGCILYEMLCGYPPFP

-----------------ISKLFNQE-------KGFT-------STVI
                 |.|... .       . ..          .
QMQMMFKKIGSPEAKDFIRKCLQKDPEKRPTAEALQDEWDIKCHPWF