IRAK-Un_br-1

Species: S.moellendorffii
Alias: IRAK-Un_br-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_br-1.AA Protein None 319 None Fasta, JSON
IRAK-Un_br-1.NA RNA None 960 None Fasta, JSON
IRAK-Un_br-1.kin_dom Protein Kinase Domain None 110 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_br-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_br-1.AA TKL 28-245 19 3.3e-24 84.09 In-house 116-364 (364) Show / Hide
Range on Protein: 28-245
Range on HMM: 116-364/364
Sequence Identity: 19% (54 aa)

VYEIQANGS-LDRLLYGRSRDRPPLDWATRVRIATDAARGLAFLHERSP-----TKLMYKDFRTFNVHVDKELR--------------ARLMGYGFTQRF
|.|   .|| |..|.           |  |.|.| |.|||...|| . |      .. . |  . |. ||. ..              . .  .|. ...
VMEYCPGGSLLHYLH-----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCKICDFGLSRFM

-----MNPSSLMVR----SKVLAERILTRCC-SLCLKVAAYAAPELLQRGAQ-------------SLPSPKSNVWSFGVVLLEILTGRQNRDEMFAVEEQ
     || .. ...    .. . .  . ..| ...     . |||.|.   .             .  |.|. |.|||.|| ||||...        ...
SQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPR-----WMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR------PYYDY

DLVGWTAPYLANDKKLFLVVDPELKGMFP------------ARSVSLFAKLAAQCLQRDPAARPSMDQVVQSL
.   . .  .  .  . .|.|  |.   |                  ..||. .| . || .|||...... |
PYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase IRAK-Un_br-1.AA IRAK 153-245 22 4.3e-11 35.7 In-house 202-317 (317) Show / Hide
Range on Protein: 153-245
Range on HMM: 202-317/317
Sequence Identity: 22% (27 aa)

SPKSNVWSFGVVLLEILTGR-QNRDE--------MFAVEEQDLVG-----------------WTAPYLANDKKLFLVVDPELKGMFPARSVSLFAKLAAQ
..|. | |||.||||.|||. . .|.            |. .  |                 | ||  . . ..|.    ..... |  ..  .. .| .
TKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFID---HRMPPCPPNMEKEMCQCACC

CLQRDPAARPSMDQVVQSL
|. .  . |..|..|.|.|
CGHHRANRRCDMAWVMQQL

Kinase IRAK-Un_br-1.AA Pkinase 138-245 18 4.6e-10 36.68 Pfam 177-293 (293) Show / Hide
Range on Protein: 138-245
Range on HMM: 177-293/293
Sequence Identity: 18% (26 aa)

YAAPELLQRGAQSLPSPKSNVWSFGVVLLEILTGRQNRDEMFAVEEQDLVGWTAPYLAN--------DKKLFLVVDPELKGMFPARSV------------
|.|||...   ..  .||. .||.|..| | |.||                   |.           ....... .|.|.  .|  .             
YMAPEVIR--GGQYYGPKVDMWSCGCILYEMLCGR------------------PPFPGHCWHDNHDQMQMICRIMGPPLHFDWPWWCSISYFFFRHWHFH

-------SLFAKLAAQCLQRDPAARPSMDQVVQS--L
       . . ..   ||..||. ||. .|..|.  .
WTFHNWSEECKDFIKWCLCKDPKKRPTAEQILQHPWF

Kinase IRAK-Un_br-1.AA LRRK 34-75 25 1e-09 30.55 In-house 139-185 (351) Show / Hide
Range on Protein: 34-75
Range on HMM: 139-185/351
Sequence Identity: 25% (12 aa)

NGSLDRLLYGRSRDR-----PPLDWATRVRIATDAARGLAFLHERSP
.|.|...|  ...|.     . ..| .. .||.. |.|...|| ..|
HGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHNP

Kinase IRAK-Un_br-1.AA IRAK 15-75 31 2e-08 26.15 In-house 68-130 (317) Show / Hide
Range on Protein: 15-75
Range on HMM: 68-130/317
Sequence Identity: 31% (20 aa)

ILGFSFTTDEKLVVYEIQANGSLDRLLYGRSRDRPP--LDWATRVRIATDAARGLAFLHERSP
..|... ...   ||.  .||||   | ..  . ||  | | .|. |.  .|.|. |||. .|
LYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNHP

Kinase IRAK-Un_br-1.AA TK-Unique 140-170 46 2e-08 25.29 In-house 204-234 (294) Show / Hide
Range on Protein: 140-170
Range on HMM: 204-234/294
Sequence Identity: 46% (15 aa)

APELLQRGAQSLP-SPKSNVWSFGVVLLEILT
||| |..  .    ..||.||||||.. ||.|
APESLKCY-HGMYHTTKSDVWSFGVLMWEIFT

Kinase IRAK-Un_br-1.AA TK 140-170 40 1.9e-07 20.22 In-house 353-389 (486) Show / Hide
Range on Protein: 140-170
Range on HMM: 353-389/486
Sequence Identity: 40% (15 aa)

APELLQRGA------QSLPSPKSNVWSFGVVLLEILT
||| |. .           ..|| ||||||.. ||.|
APECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT

S_TKc IRAK-Un_br-1.AA S_TKc 1-250 13 2.3e-07 -68.83 SMART 15-231 (231) Show / Hide
Range on Protein: 1-250
Range on HMM: 15-231/231
Sequence Identity: 13% (39 aa)

VKEIVCLR------------------------DAHLSRILGFSFTTDEKLVVYEIQAN--GSLDRLLYGRSRDRPP--LDWATRVRIATDAARGLAFLHE
|.  .  .                          .. .....  . |.  .| |   .  |.| ...  | | ...  ..  .  ...   ...|...|.
VYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARFYMYQICCALEYCHS

RSPTKLMYKDFRTFNVHVDKELRARLMGYGFTQRFMNPSSLMVRSKVLAERILTRCCSLCLKVAAYAAPELLQRGAQSLPSP-KSNVWSFGVVLLEILTG
.   . .. |    |. .|.  .  .   |.  ..                      . .     | |||.|        .. |. .||.|..| | |.|
H---GIIHRDLKPENILLDE--HIKICDFGLARQL----------------------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCILYEMLCG

RQ---NRDEMFAVEEQDLVGWTAPYLANDKKLFLVVDPELKGMFPARSVSLFAKLAAQCLQRDPAARPSMDQVVQ----SLEHVQA
.    . ..|| .                                  | ..   .  .|||.||. ||.  .. |       |   
YPPFPQMQMMFKKIG--------------------------------SPEAKD-FIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase IRAK-Un_br-1.AA DRK 220-247 35 3.2e-07 20.53 In-house 231-258 (258) Show / Hide
Range on Protein: 220-247
Range on HMM: 231-258/258
Sequence Identity: 35% (10 aa)

FAKLAAQCLQRDPAARPSMDQVVQSLEH
...|   |.  ||  ||||..... || 
YIQLMNDCWNEDPQHRPSMQECLERLEA

Kinase IRAK-Un_br-1.AA Dicty4 220-247 36 4.5e-07 19.83 In-house 248-277 (277) Show / Hide
Range on Protein: 220-247
Range on HMM: 248-277/277
Sequence Identity: 36% (11 aa)

FAKLAAQCLQRDPAARPSMDQVVQS--LEH
...| . |.  ||  |||. ...|   |||
WKHLIQWCWDHDPQHRPSFEEIIQRRILEH

TyrKc IRAK-Un_br-1.AA TyrKc 1-245 14 4.9e-07 -108.95 SMART 1-280 (280) Show / Hide
Range on Protein: 1-245
Range on HMM: 1-280/280
Sequence Identity: 14% (46 aa)

VK-------------------------------------EIVCLRDA-----HLSRILGFSFTT-------DEKLVVYEIQANGSLDRLLYGRSRDRPPL
..                                     |.  ..       .. |..|   .        .  ..| |  ..|.|.  |  . ..   |
ITLGKKLGEGAFGEVYKGTWKIQVAVKMLKEDAREDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK---L

DWATRVRIATDAARGLAFLHERSPTKLMYKDFRTFNVHVDKELRARLMGYGFTQRFMNPSSLMVR------SKVLAER--------ILTR----CCS--L
 ... . .....|.| ..||..   ..   |  . |. |....                    |.      |. . .           .     ..   |
CMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENH-------------------TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTML

CLKVAAYAAPELLQRGAQSLPSPKSNVWSFGVVLLEILT-GRQNRDEM----FAVEEQDLVGWTAPYLANDKKLFLVVDPELKGM-FPARSVSLFAKLAA
 ..     ||| .     .  ..|| ||||||.. ||.| | |   .|       .|         |. . . .    ...   | |  .  .   ..  
PIR---WMAPECI---NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQE------VIEYVKQGYRMPQPPNDY-P-MSF-VCCPDEMYQIMK

QCLQRDPAARPSMDQVVQSL
|| ..||. ||.. .... .
QCWHEDPEDRPTFSEIHECF

Kinase IRAK-Un_br-1.AA MLK 220-245 50 5.1e-07 20.54 In-house 266-291 (291) Show / Hide
Range on Protein: 220-245
Range on HMM: 266-291/291
Sequence Identity: 50% (13 aa)

FAKLAAQCLQRDPAARPSMDQVVQSL
..||  || . ||. |||..|.|| |
WKKLMKQCWNQDPHKRPSFRQIVQHL

Kinase IRAK-Un_br-1.AA TK 217-245 22 3e-06 16.17 In-house 447-486 (486) Show / Hide
Range on Protein: 217-245
Range on HMM: 447-486/486
Sequence Identity: 22% (9 aa)

V-----------SLFAKLAAQCLQRDPAARPSMDQVVQSL
.            ... |  || ..||. ||...|... |
MRYRMHPPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL

Kinase IRAK-Un_br-1.AA MLK 136-172 45 4e-06 17.51 In-house 197-233 (291) Show / Hide
Range on Protein: 136-172
Range on HMM: 197-233/291
Sequence Identity: 45% (17 aa)

AAYAAPELLQRGAQSLPSPKSNVWSFGVVLLEILTGR
.|. ||| .|.   .  | |. |||.|||| |.||..
YAWMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE

Kinase IRAK-Un_br-1.AA TK 7-73 8 1.2e-05 14.09 In-house 100-253 (486) Show / Hide
Range on Protein: 7-73
Range on HMM: 100-253/486
Sequence Identity: 8% (13 aa)

LRDAHLSRILGFSFTTDEK------------LVVYEIQANGS----LDRLLYGRSRDRPP----------------------------------------
..  .. |..| ..  ..|            ..| |  ..|.    |.  |  ..... .                                        
GHHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQD

--------------------------------LDWATRVRIATDAARGLAFLHER
                                |. .... .. ..|.|...||..
YDDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSK

Kinase IRAK-Un_br-1.AA UTK 26-73 32 1.3e-05 15.19 In-house 86-137 (296) Show / Hide
Range on Protein: 26-73
Range on HMM: 86-137/296
Sequence Identity: 32% (17 aa)

LVVYEIQANGSLDRLLYGRSRDRP-PLDWAT---RVRIATDAARGLAFLHER
..|.| ..||.|. .|   ... | . .| |   |.  | | |||...||..
MIVTEYMENGDLRSYLRRHRPTPPACPHWLTLHQRLCMAWDIARGMQYLHSC

Kinase IRAK-Un_br-1.AA Dicty4 50-75 44 1.4e-05 14.78 In-house 105-133 (277) Show / Hide
Range on Protein: 50-75
Range on HMM: 105-133/277
Sequence Identity: 44% (13 aa)

PLDWATRVR---IATDAARGLAFLHERSP
.||| .. |   .| |||||.. ||.. |
KLDWPLIKRAMRMAFDAARGMNWLHCCNP

Kinase IRAK-Un_br-1.AA UTK 140-171 50 2.9e-05 13.98 In-house 207-236 (296) Show / Hide
Range on Protein: 140-171
Range on HMM: 207-236/296
Sequence Identity: 50% (16 aa)

APELLQRGAQSLPSPKSNVWSFGVVLLEILTG
||| |  ..   .. || |||||||. ||.|.
APEALTHHT--RFTTKSDVWSFGVVCWEIWTW

Kinase IRAK-Un_br-1.AA TKL-Unique 136-173 42 4.3e-05 14.12 In-house 190-226 (290) Show / Hide
Range on Protein: 136-173
Range on HMM: 190-226/290
Sequence Identity: 42% (16 aa)

AAYAAPELLQRGAQSLPSPKSNVWSFGVVLLEILTGRQ
. ..|||.| .   .. | || |.|||.|| ||.|. .
FRWMAPEVLRMNF-CQYSEKSDVYSFGIVLWEIATRKI

Kinase IRAK-Un_br-1.AA DRK 51-75 32 0.000112 11.81 In-house 95-119 (258) Show / Hide
Range on Protein: 51-75
Range on HMM: 95-119/258
Sequence Identity: 32% (8 aa)

LDWATRVRIATDAARGLAFLHERSP
.||  . ... |.|.|. .|| . |
MDWPLMKQMMFDCAKGMIYLHCCNP

Kinase IRAK-Un_br-1.AA TKL-Unique 226-245 45 0.000113 12.61 In-house 271-290 (290) Show / Hide
Range on Protein: 226-245
Range on HMM: 271-290/290
Sequence Identity: 45% (9 aa)

QCLQRDPAARPSMDQVVQSL
||  .||  ||| |... .|
QCWHHDPSQRPSFDEIIHRL

Kinase IRAK-Un_br-1.AA TKL-Unique 50-103 25 0.000187 11.83 In-house 106-163 (290) Show / Hide
Range on Protein: 50-103
Range on HMM: 106-163/290
Sequence Identity: 25% (15 aa)

PLDWATRVRIATDAARGLAFLHERSPTKLMYKDFRTFNVHVDKE-----LRARLMGYGF
.|... ||..| |.|.|. .|| ..|.  .  | .. |. || .     ..... . |.
KLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGL

Kinase IRAK-Un_br-1.AA TK-Unique 226-245 40 0.000305 10.67 In-house 275-294 (294) Show / Hide
Range on Protein: 226-245
Range on HMM: 275-294/294
Sequence Identity: 40% (8 aa)

QCLQRDPAARPSMDQVVQSL
.|.|..|  ||| .|... |
SCWQWEPEERPSFRQIKHRL

Kinase IRAK-Un_br-1.AA MLK 33-75 28 0.000446 10.19 In-house 93-145 (291) Show / Hide
Range on Protein: 33-75
Range on HMM: 93-145/291
Sequence Identity: 28% (15 aa)

ANGSLDRLLYG-RSRDRP---------PLDWATRVRIATDAARGLAFLHERSP
..||| ..|.| ||   .           | .  ...|.. |||...||.  |
EGGSLYNVLHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAP

Kinase IRAK-Un_br-1.AA LRRK 226-247 40 0.001001 9.04 In-house 330-351 (351) Show / Hide
Range on Protein: 226-247
Range on HMM: 330-351/351
Sequence Identity: 40% (9 aa)

QCLQRDPAARPSMDQVVQSLEH
.| | ||  ||.. |.|. |. 
HCWQHDPKKRPHFSQIVKRLSQ

Kinase IRAK-Un_br-1.AA UTK 222-245 33 0.001054 8.55 In-house 273-296 (296) Show / Hide
Range on Protein: 222-245
Range on HMM: 273-296/296
Sequence Identity: 33% (8 aa)

KLAAQCLQRDPAARPSMDQVVQSL
.|  .| . ||. ||.....|| .
RLMHRCWHYDPQERPDFEDLVQQM

Kinase IRAK-Un_br-1.AA Pkinase_Tyr 226-245 35 0.001592 12.56 Pfam 251-270 (270) Show / Hide
Range on Protein: 226-245
Range on HMM: 251-270/270
Sequence Identity: 35% (7 aa)

QCLQRDPAARPSMDQVVQSL
|| . ||. ||.. .... |
QCWHYDPEDRPTFSEIHEQL

Kinase IRAK-Un_br-1.AA Pkinase_Tyr 33-73 21 0.021376 8.74 Pfam 90-130 (270) Show / Hide
Range on Protein: 33-73
Range on HMM: 90-130/270
Sequence Identity: 21% (9 aa)

ANGSLDRLLYGRSRDRPPLDWATRVRIATDAARGLAFLHER
..|.|.  |  .. |..||.  . . .... |.|...|...
PHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLESK

Kinase IRAK-Un_br-1.AA Pkinase_Tyr 158-173 64 0.026571 8.42 Pfam 197-213 (270) Show / Hide
Range on Protein: 158-173
Range on HMM: 197-213/270
Sequence Identity: 64% (11 aa)

VWSFGVVLLEILT-GRQ
||||||.. ||.| |.|
VWSFGVLMWEIFTYGEQ

Kinase IRAK-Un_br-1.AA Dicty4 155-171 64 0.068482 2.29 In-house 197-213 (277) Show / Hide
Range on Protein: 155-171
Range on HMM: 197-213/277
Sequence Identity: 64% (11 aa)

KSNVWSFGVVLLEILTG
|. | ||| || ||||.
KADVYSFGIVLWEILTR

Kinase IRAK-Un_br-1.AA DRK 155-170 50 0.188594 0.72 In-house 182-197 (258) Show / Hide
Range on Protein: 155-170
Range on HMM: 182-197/258
Sequence Identity: 50% (8 aa)

KSNVWSFGVVLLEILT
|  |.||..|| |..|
KADVYSFAIVLWECVT

Kinase IRAK-Un_br-1.AA Pkinase 34-74 12 3.292922 1.82 Pfam 84-128 (293) Show / Hide
Range on Protein: 34-74
Range on HMM: 84-128/293
Sequence Identity: 12% (6 aa)

NG----SLDRLLYGRSRDRPPL--DWATRVRIATDAARGLAFLHERS
.|    .| ... .  ... ..  .. .  ....  .|||...|...
GGLYVMDLFDYIST--WRHGCFYFSEWECKFYMYQILRGLEYCHSMG