Gene IRAK-Un_cb (S.moellendorffii)

IRAK-Un_cb

Species: S.moellendorffii
Alias: IRAK-Un_cb
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_cb.AA Protein None 524 None Fasta, JSON
IRAK-Un_cb.NA RNA None 1575 None Fasta, JSON
IRAK-Un_cb.kin_dom Protein Kinase Domain None 252 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_cb.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_cb.AA Ciliate-E2 81-329 18 1.4e-36 123.1 In-house 1-360 (365) Show / Hide 
Range on Protein: 81-329
Range on HMM: 1-360/365
Sequence Identity: 18% (70 aa)

YRIVGVLGSGGVGVTYEAET-EQGDAVAIK---------------AMSLRNMKGW--KDLDLFEREARVLK----------------SLQHSGIPEYIDF
| .. ..|.|. |. |...  ...  .|||               .... .||    ...  ...| ....                .|.|  | .....
YKFIKKIGQGNFGSVYKCKVWKVQKQFAIKIIDQKQQRQQMQEKVKIKIYAMKIMKKNQIEQIKQEIHIMREINCFYKKINEKNILEQLNHPNIIKMYEC

FEIENEKDKGFYIVQKVAKGKSLAKLVEEGW-----------RVSEQEVKDIAIEILD---------------VLKYLGSLRPPVIHRDIKPDNIILDEA
|.  ...|. .|.|   ..|..| .. .. .           . .|.|.|.|  .||.                |.|| |  . .|||||||.||..   
FQ--EKDDNNIYLVMEYCQGGDLFDYIKNNKKKRNHEIEKDKYFTEKEIKYIMKQILQGFKTKAEFYIACIILALEYLHSKNN-IIHRDIKPENILF---

TGKVKVVDFGAVQDTTSS------------ATFIG-------------------STVVGTYGYMAPEQFQNRA----------TLQTDLYGLGGTLLFML
   .|..|||  .. . .             .| .                    |..||.|||||| ...            . . |.. || .| .||
---IKIIDFGLSKKYDDDNQNRTHKQQCKWYMF-KNDTSRTPGYMDQIIQQNMFNTICGTPGYMAPEILNGKKYDNQQKQKGYDYKCDIWSLGVILYEML

SGRSPATFPQKRL-RVDFQ----------------NFVSASPSMTRVVEK----LLEPAPEDRYQSADEVI
.|. |  . |.    .||.                .. . |...     |    .|.  || |........
FGKPPF-QQQIKQCKIDFPCPEWQKDTQCIQCKWKSWKKWSQECKDLIKKFGKRMLQKDPEKRITGWEQIL
S_TKc IRAK-Un_cb.AA S_TKc 81-332 24 1.6e-35 125.21 SMART 1-231 (231) Show / Hide 
Range on Protein: 81-332
Range on HMM: 1-231/231
Sequence Identity: 24% (67 aa)

YRIVGVLGSGGVGVTYEAETEQ-GDAVAIKAMSLRNMKGWKDLDLFEREARVLKSLQHSGIPEYIDFFEIENEKDKGFYIVQKVAKG--KSLAKLVEEGW
|.|. ..|.|. |. | .     |  |||| ..          . ..|| ..||. .|  |  ..|.|.      . .|.|   . |   .| .. ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK----------EHIRREIQILKK-HHPNIVKLYDVFQD-----DHLYMVMEYCDGDLGDLFDYIKKRG

R------VSEQEVKDIAIEILDVLKYLGSLRPPVIHRDIKPDNIILDEATGKVKVVDFGAVQDTTSSATFIGSTVVGTYGYMAPEQFQNRATL-QTDLYG
|       .| ... .. .|.. |.|. |.   .||||.||.|| |||    .|. |||             .|..||  ||||| .    .    | . 
RHGLRFPFPE-HARFYMYQICCALEYCHSH--GIIHRDLKPENILLDE---HIKICDFGLARQL--------TTFCGTPWYMAPEVL--GYGKCKCDWWS

LGGTLLFMLSGRSPATFPQKRLRVDFQNFVSASPSMTRVVEKLLEPAPEDRYQSADEVI--------RAL
.| .|  ||.|. |       . . |.. .  ||..   ..|.|.  ||.|.   .             .
CGCILYEMLCGYPPFP----QMQMMFKKIG--SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-Un_cb.AA Pkinase 81-284 29 2e-33 119.28 Pfam 1-211 (293) Show / Hide 
Range on Protein: 81-284
Range on HMM: 1-211/293
Sequence Identity: 29% (68 aa)

YRIVGVLGSGGVGVTYEAETEQGDA--VAIKAMSLRNMKGWKD-----LDLFEREARVLKSLQHSGIPEYIDFFEIENEKDKGFYIVQKVAKGK----SL
|.|....|||. |. |.. ...|.   ||.| ...|. | |||     |    .|....|.|.|  | ...|.||     ..  |.|.  . |     .|
YHIGRKIGSGSFGCVYKC-HHKGTGKIVAVKIIKKRHEKSWKDQTHRRL----SEIQIMKRLNHPNIVRLYDWFED----KDHIYMVMEYCEGGLYVMDL

AKLVE--EGWRV--SEQEVKDIAIEILDVLKYLGSLRPPVIHRDIKPDNIILDEATGKV----KVVDFGAVQD--TTSSATFIGSTVVGTYGYMAPEQ--
. ...  .. ..  ||.|.|... .||  |.|. |    .||||.||.|| .|  .| .    |. |||      . ..  .  .|..||..|||||   
FDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHSM--GIIHRDLKPENILID-NNGHIDACVKICDFGLAKQFDY-NNS-M--TTFCGTPWYMAPEVIR

FQNRATLQTDLYGLGGTLLFMLSGRSP
...  .   | ...| .|  ||.|| |
GGQYYGPKVDMWSCGCILYEMLCGRPP
Kinase IRAK-Un_cb.AA STE 81-284 23 3.2e-32 111.12 In-house 1-267 (359) Show / Hide 
Range on Protein: 81-284
Range on HMM: 1-267/359
Sequence Identity: 23% (65 aa)

YRIVGVLGSGGVGVTYEAETE----------------QGDAVAIKAMSLRNMK-----------GWK---DLDLFEREARVLKSLQ--HSGIPEYIDFFE
.......|.|. |..| |                   .|. .||| |.|.| .            .|   ... ...| ...| ..  |  | .|.. ..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

IENEK---DKGFYIVQKVAKGKSLAKLVEEG--------------WRVSEQEVKDIAIEILDV-LKYLGSLRPPVIHRDIKPDNIILDEATGKVKVVDFG
 |...   |   .|.     | || .....               .|..|.... |. .||   |.|| |..  .|||||||.|| |      || .|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH--IIHRDIKPANILL------VKLCDFG

AVQDTTS---------------SATFIGSTVVGTYGYMAPEQFQNR-------ATLQTDLYGLGGTLLFMLSGRSP
     |.               .      |.|||  .||||  |..        . . | . || |.. |. |. |
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGKPP
Kinase IRAK-Un_cb.AA CAMK 86-284 18 7.1e-31 96.16 In-house 1-333 (425) Show / Hide 
Range on Protein: 86-284
Range on HMM: 1-333/425
Sequence Identity: 18% (63 aa)

VLGSGGVGVTYEAETE-QG------------DAVAIKAMSLRNMKG----------------------W---KDLDLFEREARVLKSLQ-------HSGI
.||.|. |. ....    .              |||| .. . .|.                      |   ||.. ..|| ...|.||       |  |
TLGRGSFGKVKLCIHKNTTGKERVHHIYTNGQKVAIKIIDKKKLKDKQNQDYSNCYKIDKSKCKHRYCWRRPKDRKNVRREIEIMKKLQGIGNKLDHPNI

PEYIDFFE----------------IENEKDKGFYIV----QKVAKG----KSLAKLVEEGW--------------RVSEQEVKDIAIEILDVLKYLGSLR
   ....|                .  .||| .|.|      .  |      . ..|| |               |..|.|.. .   |.. ..|. |. 
IKLYEVYEDPHYFKNTNDYETSKQVF-TKDKHMYMVMEIMEYCSGGELFDDLFDYIVEHGCYGEEFDQFDIVERGRFTEREARRYFRQICSAVHYCHSHN

PPVIHRDIKPDNIILDEAT----------------GKVKVVDFGAVQDTTSSA----------------------TFIGSTVVGTYGYMA-PEQFQNR--
  ..|||.||.|| ||.                  ...|..|||  .  ...                       .   .|..|| .||| || ..    
--IVHRDLKPENILLDDNNDDSDPVEHDEIFDWNNNNIKIIDFGFANKFDPGENNFMCSDYKGGEMHNQWTTPTEGQKMKTFCGTPEYMAAPEVLNGKGH

-------------ATLQTDLYGLGGTLLFMLSGRSP
              . ..|   .|  | .||.|..|
CNMQNATDEEKPYYGPKCDMWSCGVILYIMLCGYPP
Kinase IRAK-Un_cb.AA Ciliate-E2-Unclassified 81-284 22 7e-29 97.32 In-house 1-269 (352) Show / Hide 
Range on Protein: 81-284
Range on HMM: 1-269/352
Sequence Identity: 22% (62 aa)

YRIVGVLGSGGVGVTYEAET-EQGDAVAIKAMSLRNMKGWKDL-----------DLFERE-------ARVLK-SLQHSGIPEYIDFFEIENEKDKGFYIV
|.|. ..|.|| |. |...  .|. . |.| |.  ...  |              .....        . .. .|...  |  . .|.... |.. .|||
YKIIKQIGQGGFGKVYKCQHKKQKQYYAMKYMKKIQIYKQKQIMNKDEIMNEMKEMNNKKKYHQRKYNKIMQQILLNHPHPFIVKMFYCFQDKQN-IYIV

QKVAKGKSLAKLVEEGWR-----------------VSEQEVK-----DIAIEILDVLKYLGSLRPPVIHRDIKPDNIILDEATG--KVKVVDFGAV----
   ..|..| .  .. .                  ..||..|     ... .||. |.|| .    .|||||||.||..|.  .  ..|. |||      
MEYCEGGDLWQYIKKRKKQKQKGNDLFHNMKQRKIFTEQQAKYKKAKFYFAQILQGLEYLHHKN-NIIHRDIKPENILFDNNGKNYYIKIIDFGISKKYQ

QDTTSSATF-----------IGSTVVGTYGYM----APEQFQN-RATLQ----TDLYGLGGTLLFMLSGRSP
|.  .  |.           . .|..||..||    ||| .|.     .     | ..||  | .|| |. |
QNNNCD-TNQQQKMQIWKQQMMWTFCGTPNYMPQYTAPEVLQGQNYDHSKAYKCDIWSLGVILYEMLFGYYP
Kinase IRAK-Un_cb.AA TKL 87-284 19 1.8e-21 74.06 In-house 1-288 (364) Show / Hide 
Range on Protein: 87-284
Range on HMM: 1-288/364
Sequence Identity: 19% (56 aa)

LGSGGVGVTYEAETEQ---------GDAVAIKAMSLRNMKG------------------------WKDLDLFEREARVLKSLQHSGIPEYIDFFEIENE-
.|||| |. | ..  .         |  ||.| .. .|..                         ..  . .|.|......|.|  |  .. .   ..  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

--------KDKGFYIVQKVAKGKSLAKLVEEGWRVSEQEVKDIAIEILDVLKYLGSLR------PPVIHRDIKPDNIILDE-------------ATGKVK
         .. ..||   ..| ||  ..        .   ..|..|   . || | .      ||.||||.|..|| .||             |....|
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNADWCCK

VVDFGAVQDTT----SSATF--------------IGSTVVGTYGYMAPEQFQ-----------------NRATLQTDLYGLGGTLLFMLSGRSP
. |||  .. .    ...|                 .|..||...|||| ..                   .. ..| |  |  |  .|... |
ICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCRP
Kinase IRAK-Un_cb.AA Ciliate-E2b 127-284 26 9.7e-20 56.8 In-house 49-209 (272) Show / Hide 
Range on Protein: 127-284
Range on HMM: 49-209/272
Sequence Identity: 26% (45 aa)

REARVLKSLQHSGIPEYIDFFEIENEKDKGFYIVQKVAKGKSLAKLVEEGW--RVSEQEVKDIAIEILDVLKYLGSLRPPVIHRDIKPDNIILDEATGKV
.|  ||. ..|  |  .|. |      |.  | . .  .| .|  .. |     .|.......  .|.  |.|| ..   .|.||||| ||..|.. | .
QEKNVLEKCNHPFIMKFIRSF----KDDQHMYFMMEFCNGMELFDVIREIGRLLLSTYDSQFYIASICLCLEYLHNQN--IIYRDIKPENIMVDHK-GYM

KVVDFGAVQDTTSSATFI--GSTVVGTYGYMAPEQFQ-----NRA-TLQTDLYGLGGTLLFMLSGRSP
| .|.|.     ...  .    |..||  |||||  |     ..  | . |.. .| .| ....|. |
KLIDMGTAKHMYKKNEQMTRTFTIIGTPHYMAPEIIQSLQPGGKGYTYKVDIWSVGICLYEFMCGYVP
Kinase IRAK-Un_cb.AA ULK 81-321 22 2.2e-19 65.46 In-house 1-312 (324) Show / Hide 
Range on Protein: 81-321
Range on HMM: 1-312/324
Sequence Identity: 22% (73 aa)

YRIVGVLGSGGVG-VTYEA---ETE-QGDAVAIKAMSLRNMKGWKDL-------DLFEREARVLKSLQ------HSGIPEYIDFFEIENEKDKGFYIVQK
| .  .||.|  | . |..   .|. |. .||.| ... .|.  | .       .|...| ...| |       |  | ...|.||  |.  . .||.. 
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLYDWFETSNH--NNIYIIME

VAKGKSLAKLVE---------EGWRVSEQEVKDIAIEILDVLKYLGSLRPPVIHRDIKPDNIILDEATGK-----------VKVVDFGAVQDTTS--SAT
   |  | .. .         |. | ||||.. . . |.  .|.| .    .|||||||.|| . . ..|           .|. |||  .   .   . 
YCNGGDLEQYIKKNKKLPETEEKKRLSEQEAIQFFKQICNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNNNMEQ

FIGSTVV------GTYGYMAPEQFQNR-----AT-LQTDLYGLGGTLLFMLSGRSP---ATFPQKR-------------------LRVDFQ---NFVSAS
..  | |      ||  ||||. .|..      .   .|.. ||  .  || |. |     | .                       ..|.   . .  |
QMCQTCVNEKRIKGTPLYMAPQILQGQGEQKPYYDYKCDIWSLGCIFYEMLYGKYPFFSW-FNDQYLYIQKLINNGKEQQIYIKNQPIQFPKPPKDPKIS

PSMTRVVEKLLEPAPEDR
| .     ..|.  ..||
PECKDLIRRMLQYDEKDR
Kinase IRAK-Un_cb.AA ULK 81-272 24 7.1e-17 55.51 In-house 1-243 (329) Show / Hide 
Range on Protein: 81-272
Range on HMM: 1-243/329
Sequence Identity: 24% (61 aa)

YRIVGVLGSGGVGVTYEAE---TE--QGDAVAIKAMSLRNMKGWKDLD-------LFEREARVLKSL----QHSG----IPEYIDFFEIENEKDKGFYIV
| .  .||.|  |. |...   |.  .. .||.| ...  |.  ....       |...| ...| |    .|      | ...|.||  |.  . .||.
YCLNHCLGKGSFGKVYKGRNKKTKDYVNEKVACKMIDKQKMNQKNNEQEGQYMWQLLKNEIKIMKKLKSPNRHKNHHPNIVKLYDWFETSNH--NNIYII

QKVAKGKSLAKLVE----------EGWRVSEQEVKDIAIEILDVLKYLGSLRPPVIHRDIKPDNIILDEATGK-----------VKVVDFGAVQDTTSS-
.    |  | .. .          |. | ||||.. . . ||  .|.| . .  .|||||||.|| ... ..|           .|. |||  .  ... 
MEYCNGGDLEQYIKKNKKLPEDTEEKKRLSEQEAIQFFKQILNGFKELHKHN--IIHRDIKPQNILIHNGQPKTDSKKVHPNGVLKIADFGFAKHVDNDN

-ATFIGSTVV------GTYGYMAPEQFQNR-----AT-LQTDLYGLG
   ..  | |      ||  ||||. .|..      .   .|.. ||
MEQQMMMTCVNEKRLCGTPLYMAPQILQGQGEQKPYYDYKCDIWSLG
Kinase IRAK-Un_cb.AA MSK 180-284 29 1.8e-16 52.18 In-house 99-209 (277) Show / Hide 
Range on Protein: 180-284
Range on HMM: 99-209/277
Sequence Identity: 29% (33 aa)

SEQEVKDIAIEILDVLKYLGSLRPPVIHRDIKPDNIILDEA--TGKVKVVDFGAVQDTTSSATFIGSTVVGTYGYMAPEQFQ----NRA--TLQTDLYGL
.|.|. .|  |.   .... ...  .||||.|| || .|.    |.||..|||    .... .    .  .|  |||||  .    .      . |...|
DESECRMIMRELVMAVDHMHQKG--IIHRDLKPENILFDDEEDNGHVKLIDFGFARLFPQDEEWRMKSPCFTLHYMAPEMLRRGYAQDGGYDEACDWWSL

GGTLLFMLSGRSP
| .|  ||.|..|
GVILYTMLTGQVP
Kinase IRAK-Un_cb.AA STE20 205-256 46 2.2e-10 34.49 In-house 138-192 (288) Show / Hide 
Range on Protein: 205-256
Range on HMM: 138-192/288
Sequence Identity: 46% (27 aa)

VIHRDIKPDNIILDEATGKVKVVDFG-AVQDTT--SSATFIG---STVVGTYGYMAPE
.|||||| ||| |.|  |.|| .||| . | |.       ..    |.|||  .||||
IIHRDIKADNILLTE-DGEVKLADFGVCAQLTKHGR-D-TMQFKRNTFVGTPYWMAPE
Kinase IRAK-Un_cb.AA TyrKc 81-332 17 1.3e-09 -67.03 SMART 1-280 (280) Show / Hide 
Range on Protein: 81-332
Range on HMM: 1-280/280
Sequence Identity: 17% (50 aa)

YRIVGVLGSGGVGVTYEAETEQGDAVAIKAMSLRNMKGWKDLDLFEREARVLKSL--QHSGIPEYIDFFEIENE---KDKGFYIVQKVAKGKSLAKLVEE
 .   .||.|  |. |...      ||.| .          .  | ||||....|  .|  |   .     . .    ..  .||   ... .| .   .
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA------REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRK

GWR-VSEQEVKDIAIEILDVLKYLGSLRPPVIHRDIKPDNIILDEATGKVKVVDFGAVQDTTSS-------ATFI-----GSTVVGTYGYMAPEQFQNR-
  . .. ..  .... | .   || |   ..||||.   |. ..|    ||. |||   | ..         .       |.  .  .  |||| .. . 
HRPKLCMKDLLSFCWQIACGMEYLHSK--NCIHRDLAARNCLVGENH-TVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

ATLQTDLYGLGGTL--LFMLSGRSPAT-----FPQKRLRVDFQNF------VS--------ASPSMTRVVEKLLEPAPEDRYQSADEVIRAL
 | ..| .  | ..  .| . .  .        . .... . ..        .        ... | .. ..  .  ||||  .  |... .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDR-PTFSEIHECF
Kinase IRAK-Un_cb.AA STE20 81-155 22 3e-08 26.56 In-house 1-82 (288) Show / Hide 
Range on Protein: 81-155
Range on HMM: 1-82/288
Sequence Identity: 22% (19 aa)

YRIVGVLGSGGVGVTYEAET-EQGDA----VAIKAMSLRNM---KGWKDLDLFEREARVLKSLQHSGIPEYIDFFEIENEK-DK
| .. ..|.|. |. | |   . |.     |||| |.|..    .  ..... . | ...| ..|  | .|.. .  .... |.
YELLEKIGQGSYGKVYKAYHKPTGEYCNQRVAIKKMNLEKCDNEQ--DEWEDIQKEISIMKQCKHPNIVKYYGSYLKDDTCDDE