Gene IRAK-Un_cs (S.moellendorffii)

IRAK-Un_cs

Species: S.moellendorffii
Alias: IRAK-Un_cs
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_cs.AA Protein None 291 None Fasta, JSON
IRAK-Un_cs.NA RNA None 876 None Fasta, JSON
IRAK-Un_cs.kin_dom Protein Kinase Domain None 60 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_cs.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
Kinase IRAK-Un_cs.AA TKL 80-285 15 4.7e-14 47.02 In-house 84-364 (364) Show / Hide 
Range on Protein: 80-285
Range on HMM: 84-364/364
Sequence Identity: 15% (45 aa)

HPNIVRLLGFCTSPFL-------------HALVMPLEKRGC-LKGMVLDGSLGWKQRVKIIKGLALALDHLHDAR----NVLGFQ--VLHLGVRLENVWV
|||||...|.|..|               ...|| . ..|. |  .       | ||...... |.....||  .            ..|     .|. |
HPNIVQFMGYCCCPPCGCVCMHPVGPWGQLCIVMEYCPGGSLLHYLH------WHQRCRWALDIARGMNYLHSMNPKWCT----KPPIIHRDLKSKNILV

AEDYT--------------PKLAGFYSCKIRRSRKSISGTGSQED---------------L--------EIISKQ-------------DCEGVTDKMDVL
 |..|              .|.. |  ..    ... . |.. .                         |.. .|              ..  . |.|| 
DENWTNVSNYMYNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVY

GFGFLVLEITSGRELQSNPEEMIQL------AEQKLAIERWIDPRIR---------GVPEMEARRMIQMSMLCLQSNPEARPSMGKLIPAV
 || .  || ....  ... .| ..      .........   | |            ..   ..|..  . | ...||.|||. ...   
SFGIVLWEILTRCRPYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
TyrKc IRAK-Un_cs.AA TyrKc 46-285 20 8.3e-08 -96.41 SMART 1-280 (280) Show / Hide 
Range on Protein: 46-285
Range on HMM: 1-280/280
Sequence Identity: 20% (61 aa)

IEL----------VVYKGVLGRSEVLV-----ECGKGDFKDRMTALWSP---HPNIVRLLGFCTSP-------FLHALVMPLEKRGCLKGMVLDGS--LG
|.|          .||||..   .| |     .. . || . .  . .    |||||||.| ||..         . .|| . . |.||    .    | 
ITLGKKLGEGAFGEVYKGTWK-IQVAVKMLKEDA-REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPKLC

WKQRVKIIKGLALALDHLHDARNVLGFQVLHLGVRLENVWVAEDYTPKLAGF-YSCKIRRS------RKSISGTG-SQED---------LEIISKQDCEG
.|. ...    |   ..||.       .. |      |. |.|..| | . |  | .|          . .. .. ....         .| |     .|
MKDLLSFCWQIACGMEYLHSK------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECI----NYG

V-TDKMDVLGFGFLVLEITS-GRELQSN-------PEEMIQLAEQKLAIERWID--PRIRGVPEMEARRMIQMSMLCLQSNPEARPSMGKLIPAV
. | | ||  || .  || . | .  ..       ..|.|.. .|    ..  .  | .   ... .     |.. | . .|| ||..  ..   
KFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDYP-MSF-VCCPDEMYQIMKQ-CWHEDPEDRPTFSEIHECF
Kinase IRAK-Un_cs.AA IRAK 80-140 35 1.8e-07 22.74 In-house 62-129 (317) Show / Hide 
Range on Protein: 80-140
Range on HMM: 62-129/317
Sequence Identity: 35% (24 aa)

HPNIVRLLGFCTSPFLHALVMPLEKRGC----LKGMVLDGS---LGWKQRVKIIKGLALALDHLHDAR
||||| |.|.|| .  | || |. . |     | .   ...   | | ||..|  |.|... .||...
HPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQCPPKPLSWHQRCSICWGTACGIQFLHQNH
Kinase IRAK-Un_cs.AA TK 80-138 12 6.6e-07 18.38 In-house 102-252 (486) Show / Hide 
Range on Protein: 80-138
Range on HMM: 102-252/486
Sequence Identity: 12% (19 aa)

HPNIVRLLGFCTSP------------FLHALVMPLEKRGC----LKGMVLDGS-----------------------------------------------
|||||||.| || .                .|| . . |.    |.    . .                                               
HPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDYD

------------------------------LGWKQRVKIIKGLALALDHLHD
                              |  .|.. .   .| .. .||.
DDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHS
S_TKc IRAK-Un_cs.AA S_TKc 58-287 14 4e-06 -87.12 SMART 1-231 (231) Show / Hide 
Range on Protein: 58-287
Range on HMM: 1-231/231
Sequence Identity: 14% (40 aa)

SEVLVECGKGDFKDRMTALWSP------------------------HPNIVRLLGFCTSPFLHALVMPLEKR--GCLKGMVLDGS-------LGWKQRVK
 |.| . ||| |   . . .                          |||||.|.... .     .|| .     | |. .  .         .   .  .
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIKEHIRREIQILKKHHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFPFPE-HARF

IIKGLALALDHLHDARNVLGFQVLHLGVRLENVWVAEDYTPKLAGFYSCKIRRSRKSISGTGSQEDL---------EIISKQDCEGVTD-KMDVLGFGFL
... ...||...|. .      ..|  .  ||. . |  . |.. | ....               .         |..      | .  | |.  .| .
YMYQICCALEYCHSHG------IIHRDLKPENILLDE--HIKICDFGLARQL------------TTFCGTPWYMAPEVL------GYGKCKCDWWSCGCI

VLEITSGRE-LQSNPEEMIQLAEQKLAIERWIDPRIRGVPEMEARRMIQMSMLCLQSNPEARPSMGKLIP-------AVQM
. |  .|.   . ....|...                       . .... . ||| .|| ||.  ..            .
LYEMLCGYPPFP-QMQMMFKKIG--------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-Un_cs.AA Pkinase 80-143 18 1e-05 21.33 Pfam 59-130 (293) Show / Hide 
Range on Protein: 80-143
Range on HMM: 59-130/293
Sequence Identity: 18% (14 aa)

HPNIVRLLGFC-TSPFLHALVMPLEKRG----CLKGMVL---DGSL--GWKQRVKIIKGLALALDHLHDARNVL
|||||||.... ... .. .||..   |     |. ..    .|..   ...  .... .. .|...|. ....
HPNIVRLYDWFEDKDHIY-MVMEYCEGGLYVMDLFDYISTWRHGCFYFSEWECKFYMYQILRGLEYCHS-MGII
Kinase IRAK-Un_cs.AA TK-Unique 79-110 36 7.4e-05 12.82 In-house 62-94 (294) Show / Hide 
Range on Protein: 79-110
Range on HMM: 62-94/294
Sequence Identity: 36% (12 aa)

PHPNIVRLLGFCTSPF-LHALVMPLEKRGCLKG
.|||||..|| ||...  . ..|.   .|.| .
DHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQH
Kinase IRAK-Un_cs.AA LRRK 80-140 30 8.7e-05 12.84 In-house 116-184 (351) Show / Hide 
Range on Protein: 80-140
Range on HMM: 116-184/351
Sequence Identity: 30% (22 aa)

HPNIVRLLGFCTSPFLHALVMPLEKRGCLKGMVL----DG------SLGWKQRVKIIKGLALALDHLHDAR
||||| |.||| .|.  ..|| .   | |         ||      ...|  . ||    | ....||...
HPNIVSLKGFCIHPL--CMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHN
Kinase IRAK-Un_cs.AA Pkinase_Tyr 80-138 26 0.000291 15.06 Pfam 63-129 (270) Show / Hide 
Range on Protein: 80-138
Range on HMM: 63-129/270
Sequence Identity: 26% (18 aa)

HPNIVRLLGFCT-----SPFLHALVMPLEKRGCLKGMVLDG-----SLGWKQRVKIIKGLALALDHLHD
|||||||.| ||     .   . .||.. . |.|.    .      .|  |. ...    | ....|..
HPNIVRLYGVCTDQGEPN--QIYIVMEYMPHGDLLDYLRKHREDKQPLTMKDLLQMCWQIAKGMEYLES
Kinase IRAK-Un_cs.AA TKL-ciliate2 80-137 33 0.000372 9.12 In-house 55-114 (273) Show / Hide 
Range on Protein: 80-137
Range on HMM: 55-114/273
Sequence Identity: 33% (20 aa)

HPNIVRLLGFCTSPFLHALVMPLEKRGCLKGMVLD--GSLGWKQRVKIIKGLALALDHLH
|||||  || ||     ...|   .|| | ... .    | |  | .|    |    .||
HPNIVMFLGACTKIPNFCIIMEYCQRGSLWSLLQNQDVRLTWEDRRRIALDIARGVHYLH
Kinase IRAK-Un_cs.AA TK 253-285 20 0.025873 2.7 In-house 453-486 (486) Show / Hide 
Range on Protein: 253-285
Range on HMM: 453-486/486
Sequence Identity: 20% (7 aa)

PEMEARRMIQM-SMLCLQSNPEARPSMGKLIPAV
|. ..  ...   . | . .|| ||..  |  . 
PPHCPPEEYYDLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAK-Un_cs.AA TK-Unique 267-285 36 0.331115 0.06 In-house 276-294 (294) Show / Hide 
Range on Protein: 267-285
Range on HMM: 276-294/294
Sequence Identity: 36% (7 aa)

CLQSNPEARPSMGKLIPAV
|.|..|| |||  ...   
CWQWEPEERPSFRQIKHRL
Kinase IRAK-Un_cs.AA Pkinase_Tyr 265-285 23 1.352148 2.64 Pfam 250-270 (270) Show / Hide 
Range on Protein: 265-285
Range on HMM: 250-270/270
Sequence Identity: 23% (5 aa)

MLCLQSNPEARPSMGKLIPAV
..| . .|| ||..  ..   
KQCWHYDPEDRPTFSEIHEQL