Gene IRAK-Un_cu (S.moellendorffii)

IRAK-Un_cu

Species: S.moellendorffii
Alias: IRAK-Un_cu
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_cu.AA Protein None 916 None Fasta, JSON
IRAK-Un_cu.NA RNA None 2748 None Fasta, JSON
IRAK-Un_cu.kin_dom Protein Kinase Domain None 150 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_cu.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 IRAK-Un_cu.AA LRR_1 98-120 25 3.950825 4.63 Pfam 1-26 (26) Show / Hide 
Range on Protein: 98-120
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

ALRLLNATGF--VML-GTLPDW-IGQL
 |. |.  |.  . | |..|.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_cu.AA LRR_1 122-144 33 0.043038 11.59 Pfam 1-26 (26) Show / Hide 
Range on Protein: 122-144
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

ALQVLDFSAC---SINGSVPGG-IGQL
 ||.||.| |   .. |..| . . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_cu.AA LRR_1 146-168 40 0.007169 14.35 Pfam 1-26 (26) Show / Hide 
Range on Protein: 146-168
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLRRLSLAR-N--DLMGGIPAS-IGNL
.|..|.| . |   | | || | . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_cu.AA LRR_1 170-192 40 0.000227 19.67 Pfam 1-26 (26) Show / Hide 
Range on Protein: 170-192
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

RLELLDLSG-N--MLSGVLPPE-LGRM
.|. ||||| |   |.| .||. .  .
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_cu.AA LRR_1 194-216 40 0.01455 13.26 Pfam 1-26 (26) Show / Hide 
Range on Protein: 194-216
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLRDLDLSG-N--IFSGPIPAS-LAVS
.|. ||||| |   ..| || | .   
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_cu.AA LRR_1 220-242 25 0.038791 11.75 Pfam 1-26 (26) Show / Hide 
Range on Protein: 220-242
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

SLRSVRLSD-N--RLDGSVPEN-LTGW
.|..  ||. |  .| |..|.. . . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_cu.AA LRR_1 244-266 33 0.959234 6.81 Pfam 1-26 (26) Show / Hide 
Range on Protein: 244-266
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

TLQELALGK-N--LLAGELPGA-LQDL
.||.| |.  |   | |..|   .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_cu.AA LRR_1 268-290 51 0.000284 19.32 Pfam 1-26 (26) Show / Hide 
Range on Protein: 268-290
Range on HMM: 1-26/26
Sequence Identity: 51% (14 aa)

NLTLLDLSL-N--NFTGTIPPG-LASL
||. ||||  |  |.||.|||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_cu.AA LRR_1 292-314 37 0.004762 14.98 Pfam 1-26 (26) Show / Hide 
Range on Protein: 292-314
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

SLQSLDLSN-N--TFYGPLPAA-VSSL
.||.||||. |   . | .|     .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_cu.AA LRR_1 316-349 21 4.215854 4.53 Pfam 1-26 (26) Show / Hide 
Range on Protein: 316-349
Range on HMM: 1-26/26
Sequence Identity: 21% (8 aa)

GLLVLNVSD-N--FLNDTVPAGTVAGAILSENCFVNA
 | .|..|. |   | ..          ....|| | 
NLQHLDLSGCNCCNLTGH----------IPPSCF-NL
Kinase IRAK-Un_cu.AA TKL 492-768 16 7.9e-24 82.68 In-house 1-364 (364) Show / Hide 
Range on Protein: 492-768
Range on HMM: 1-364/364
Sequence Identity: 16% (66 aa)

IKAGHSGDLYRGVLDG---------GVLVVVKRIEV----------------------------AKMKKDLLTLELEVFGKASHTRLVPLLGHCLEMDE-
|  |..|  |.|.. |         |  |.||.. .                            |.  .. .  |. .  . .|  .|...| |.. .  
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-----------LKFLVYKYMPNGDLGQALHKKVVPSPPADILQSLDWITRLKIAIGVAEGLSYLHHECV-----PPLVHRDVQASSILLDDKFE------
             ..|. |.|.|.|   ||                |  |...|...| |..||| .       ||..|||   . ||.|....      
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYM

--------VRLGSLSETREQGGEAQPGLIT---------RLLRLSQTTEQG----------------DQGSA---------VASCAYDVYCFGKVLLELV
        . .. .   |.  .. .   .          . .. ..|  |.                ..  .          .| . ||| || || |..
YNPNADWCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQ-NNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEIL

TGKLDISGTSDPNADAWLE---WALPLIDRHNKEGIMKLVDPSL--IVDE----DLLEEVWA-MAIVAKLCLHGRASKRPQIRHVLKAL
|...       | .| . .   .. | ..   .  . |   | .  |  .       . ..  |.  .. | .  ..|||    .|| |
TRCR-------PYYDYPYMPMIFQDP-FEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-Un_cu.AA IRAK 486-631 31 3.2e-21 72.05 In-house 1-151 (317) Show / Hide 
Range on Protein: 486-631
Range on HMM: 1-151/317
Sequence Identity: 31% (49 aa)

FSSSNFIKAGHSGDLYRGVLDGGV-LVVVK------RIEVAKMKKDLLT--LELEVFGKASHTRLVPLLGHCLEMDELKFLVYKYMPNGDLGQALHKKVV
|. .| |  |  |. |||....    ..||       ..  .... ...   ||.|  .  |  .|||.| |.| ...  ||| ||||| |   |.    
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCH-CLVYPYMPNGSLEDRLWCQDG

PSPPADILQSLDWITRLKIAIGVAEGLSYLHHEC-VPPLVHRDVQASSILLDDKFE
  ||    . | |..|..|..| | |. .||      |. |.|.  . ||||. |.
QCPP----KPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFT
Kinase IRAK-Un_cu.AA TK 486-635 14 1.7e-16 51.07 In-house 1-293 (486) Show / Hide 
Range on Protein: 486-635
Range on HMM: 1-293/486
Sequence Identity: 14% (42 aa)

FSSSNFIKAGHSG---DLYRGVLDGG--------------------------VLVVVKRIEV-AKMKKDLLTL-----------------ELEVFG--KA
    . . .|. |   . |.| . |.                          . | || .   . | ..   .                 |....   . 
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

SHTRLVPLLGHCLEMD-----------ELKFLVYKYMPNGD----LGQALHKKVV---------------------------------------------
 |  .| |.|.|.. .           |   .|  |||.||    | . |.|.                                               
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

----------PSPPADILQ-----------SLDWITRLKIAIGVAEGLSYLHHE----CVPPLVHRDVQASSILLDDKFE-----------VRLG
          | . .| ||            |.  ..| ..  .|.|..|||        . .||||. |  .|....             ....
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFI-QNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIA
Kinase IRAK-Un_cu.AA MLK 486-632 20 1.1e-12 40.48 In-house 1-171 (291) Show / Hide 
Range on Protein: 486-632
Range on HMM: 1-171/291
Sequence Identity: 20% (35 aa)

FSSSNFIKAGHSGDLYRGVLDGGV----LVVVKRIE-------VAKMKKDLLTLELEVFGKASHTR----LVPLLGHCLEMDELKFLVYKYMPNGDLGQA
.  . .| .|..|. ..|.  .       | |||..       ..   .. .  | . . . ||       ....| ||.     ..|  |...| |   
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

LHK-KVVPS------PPADILQSLDWITRLKIAIGVAEGLSYLHHECVPPLVHRDVQASSILLDD-----KFEV
||  .  ..      .  |. ...| .  ...|  .|.|..||| . ..|..|||   . ||.|.     . ..
LHGARSKWMDANHNQK-NDRVYDHDHA--MNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGT
Kinase IRAK-Un_cu.AA TK-Unique 486-635 19 1.7e-11 36.03 In-house 1-175 (294) Show / Hide 
Range on Protein: 486-635
Range on HMM: 1-175/294
Sequence Identity: 19% (35 aa)

FSSSNFIKAGHSGDLYRGVLDG---------GVLVVVKRIEVAKMKKDLLTLELEVFGKAS-HTRLVPLLGHCLEMDELKFLVYKYMPNGDLGQALHKKV
.   . |  |  |  .|| . |          |.|.  .... . .|. .. |.... .   |  .| .|| | . ||  .... |.|.|.|   |... 
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNLQHYLRTCR

---------------VPSPPADILQS-LDWITRLKIAIGVAEGLSYLHH--ECVPPLVHRDVQASSILLDDKFEVRLG
               ....|.. . . ..  . . .|...| |..||.   . .   ||||. |. .|| ..... ..
PAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI---VHRDLCARNVLLTEDKVCKIC
Kinase IRAK-Un_cu.AA Pkinase_Tyr 494-619 24 2.4e-11 39.08 Pfam 9-137 (270) Show / Hide 
Range on Protein: 494-619
Range on HMM: 9-137/270
Sequence Identity: 24% (34 aa)

AGHSGDLYRGVLD-----GGVLVVVKRI--EVAKM---KKDLLTLELEVFGKA-SHTRLVPLLGHCLEMDEL--KFLVYKYMPNGDLGQALHKKVVPSPP
.|. |. |.|...     ... | || .     .    ..|..  |...  .  .|  .| |.| |.. .|    ..|  |||.|||   |.|.      
EGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMR-EAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRKHR-----

ADILQSLDWITRLKIAIGVAEGLSYLHHECVPPLVHRDV
 .  |.|.  . |.... .|.|..||.      ..|||.
-EDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDL
Kinase IRAK-Un_cu.AA MLK 486-631 27 1.1e-10 31.26 In-house 1-141 (280) Show / Hide 
Range on Protein: 486-631
Range on HMM: 1-141/280
Sequence Identity: 27% (42 aa)

FSSSNFIKAGHSGDLYRGVLDGGVLVVVKRIE------VAKM--KKDLLTLELEVFGKASHTRLVPLLGHCLEMDELKFLVYKYMPNGDLGQALHKKVVP
      | .|  |  ||.. . | .| ||.        ....  . . .  |   |.  .|   . |.| |||  .|  ||  |   | | ...  | . 
LKIKEIIGNGGFGKVYRAQWK-GEEVAVKAHRQDPEQDMQQTDEQAEQVRQEARLFWMLKHPNIIALRGVCLEDPHL-CLVMEYCRGGSLNRVCAGKRI-

SPPADILQSLDWITRLKIAIGVAEGLSYLHHECVPPLVHRDVQASSILLDDKFE
  | ..|   .|      |. .|.|. |||.| . |..|||  .| ||. .| .
--PPHVL--VNW------AVQIARGMNYLHNEAPVPIIHRDLKSSNILILEKIC
Kinase IRAK-Un_cu.AA TyrKc 486-768 18 1.2e-10 -50.49 SMART 1-280 (280) Show / Hide 
Range on Protein: 486-768
Range on HMM: 1-280/280
Sequence Identity: 18% (57 aa)

FSSSNFIKAGHSGDLYRGVLDGGVLVVVKRIEVAKMKKDLLTLELEVFGKA--SHTRLVPLLGHCLEM------DELKFLVYKYMPNGDLGQALHKKVVP
 .    .  |. |  |.|...  . | || .   .  .  .  |...  |   .|  .| |.| |..       .|  ..|  |||.||| . |.|.   
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA--REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRPK

SPPADILQSLDWITRLKIAIGVAEGLSYLHHECVPPLVHRDVQASSILLDDKFEVRLGSLSETREQGGEAQPGLITRLLRLSQTTEQG-DQGS-------
         | . . |.... .|.| .|||.    ...|||  |  .|..... |. .    .|. . . | |      . .  . .. ..|        
---------LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG-----ESKDYYRKKEHKGGKTMLPIRW

----AVASCAY----DVYCFGKVLLELVT-GKLDISG-----TSDPNADAWLEWA--LPLIDRHNKEGIMKLVDPSLIVDEDLLEEVWAMAIVAKLCLHG
    .   . .    ||. || .. |. | |.   .|      |.  . ....    .|  . .  . .               .   .|  . | | | 
MAPECINYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS------------FVCCPDEMYQIMKQCWHE

RASKRPQIRHVLKAL
 ...||  . . . .
DPEDRPTFSEIHECF
Kinase IRAK-Un_cu.AA LRRK 561-618 35 9.3e-10 30.68 In-house 136-191 (351) Show / Hide 
Range on Protein: 561-618
Range on HMM: 136-191/351
Sequence Identity: 35% (23 aa)

YMPNGDLGQALHKKV------VPSPPADILQSLDWITRLKIAIGVAEGLSYLHHECVPPLVHRD
|.|.||| . ||.|       ..        ...| ..||||. .|.|. || | . ||..|||
YAPHGDLYHFLHNKKQDGFHFMK-------AHISWMLKLKIALQIAKGMEYL-HSHNPPIIHRD
Kinase IRAK-Un_cu.AA S_TKc 486-742 15 2.2e-08 -54.1 SMART 1-231 (231) Show / Hide 
Range on Protein: 486-742
Range on HMM: 1-231/231
Sequence Identity: 15% (42 aa)

FSSSNFIKAGHSGDLYRGVLDG-GVLVVVKRIEVAKMKKDLLTLELEVFGKASHTRLVPLLGHCLEMDELKFLVYKYMPN--GDLGQALHKKVVPSPPAD
.   . |  |  |  |...  . | .| .|.|       . .  |...  |  |  .| |.... .  .  ..|  |...  ||| . ..|.  . ..  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK------EHIRREIQILKK-HHPNIVKLYDVFQD--DHLYMVMEYCDGDLGDLFDYIKKRGRHGLR--

ILQSLDWITRLKIAIGVAEGLSYLHHECVPPLVHRDVQASSILLDDKFEVRLGSLSETREQGGEAQPGLITR------LLRLSQTTEQGDQGSAVASC-A
  . ..  .  ...  ....| |.|   .   .|||.  . ||||.  .. ..     |.          |.      .|                .. .
--FPFPE-HARFYMYQICCALEYCHSHGI---IHRDLKPENILLDE--HIKICDFGLARQL----TTFCGTPWYMAPEVL--------------GYGKCK

YDVYCFGKVLLELVTGKLDISGTSDPNADAWLEWALPLIDRHNKEGIMKLVDPSLIVDED------LLE-------EVWA
 |.. .| .| |...|.   .     . .. ..  .       .|..  ...  | .| .      .|.         | 
CDWWSCGCILYEMLCGYPPFP-----QMQMMFKKIG------SPEAKD-FIRKCLQKDPEKRPTAEALQDEWDIKCHPWF
Kinase IRAK-Un_cu.AA CZAK 592-628 42 2.4e-08 26.58 In-house 107-144 (279) Show / Hide 
Range on Protein: 592-628
Range on HMM: 107-144/279
Sequence Identity: 42% (16 aa)

RLKIAIGVAEGLSYLHHECVP-PLVHRDVQASSILLDD
....|| .|.|  |||    | | .|||   . ||||.
QWNMAIDIARGMNYLHDNWKPNPILHRDLSSRNILLDH
Kinase IRAK-Un_cu.AA HH498 592-627 36 2.5e-07 18.89 In-house 123-158 (284) Show / Hide 
Range on Protein: 592-627
Range on HMM: 123-158/284
Sequence Identity: 36% (13 aa)

RLKIAIGVAEGLSYLHHECVPPLVHRDVQASSILLD
.. |.. || |  |||    .| .|||     ||..
KMTISVDVAHGMNYLHNSLKHPIIHRDLNSHNILIH
Kinase IRAK-Un_cu.AA Dicty4-Unclassified 529-637 26 6.4e-07 19.7 In-house 48-153 (263) Show / Hide 
Range on Protein: 529-637
Range on HMM: 48-153/263
Sequence Identity: 26% (30 aa)

ELEVFGKASHTRLVPLLGHCLEM---DELKFLVYKYMPNGDLGQALHKKVVPSPPADILQSLDWIT--RLKIAIGVAEGLSYLHHECVPPLVHRDVQASS
| |. |  .|  || . | |.           |   |. | |    | |     |..  |..       .|.|. .| |. .||      ..|||. .| 
EVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSK-----PSEQQQPIKLDDTLIIKYAFDIAQGMQHLHTR---NFIHRDIKSSN

ILLDDKFEVRLGSL
||.|  | .. . .
ILMDKHFNIKIADF
Kinase IRAK-Un_cu.AA IRAK 742-768 33 0.000496 10.37 In-house 291-317 (317) Show / Hide 
Range on Protein: 742-768
Range on HMM: 291-317/317
Sequence Identity: 33% (9 aa)

AMAIVAKLCLHGRASKRPQIRHVLKAL
.|. .|  |.|.|| .|. .. |.. |
EMCQCACCCGHHRANRRCDMAWVMQQL
Kinase IRAK-Un_cu.AA IRAK 677-691 73 0.00808 6.02 In-house 206-220 (317) Show / Hide 
Range on Protein: 677-691
Range on HMM: 206-220/317
Sequence Identity: 73% (11 aa)

DVYCFGKVLLELVTG
||| || ||||..||
DVYSFGIVLLEVLTG
Kinase IRAK-Un_cu.AA CZAK 677-691 46 0.141678 1.68 In-house 204-218 (279) Show / Hide 
Range on Protein: 677-691
Range on HMM: 204-218/279
Sequence Identity: 46% (7 aa)

DVYCFGKVLLELVTG
||| || .| ...|.
DVYSFGMILWCIITC
Kinase IRAK-Un_cu.AA Dicty4-Unclassified 677-691 53 0.14362 1.1 In-house 190-204 (263) Show / Hide 
Range on Protein: 677-691
Range on HMM: 190-204/263
Sequence Identity: 53% (8 aa)

DVYCFGKVLLELVTG
||| .. .| ||.||
DVYSYAMMLYELATG
Kinase IRAK-Un_cu.AA TK-Unique 750-768 26 0.28085 0.31 In-house 276-294 (294) Show / Hide 
Range on Protein: 750-768
Range on HMM: 276-294/294
Sequence Identity: 26% (5 aa)

CLHGRASKRPQIRHVLKAL
|..  ...|| .| ... |
CWQWEPEERPSFRQIKHRL