IRAK-Un_bp-1

Species: S.moellendorffii
Alias: IRAK-Un_bp-1
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_bp-1.AA Protein None 992 None Fasta, JSON
IRAK-Un_bp-1.NA RNA None 2979 None Fasta, JSON
IRAK-Un_bp-1.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_bp-1.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 IRAK-Un_bp-1.AA LRR_1 179-201 33 0.127303 9.92 Pfam 1-26 (26) Show / Hide
Range on Protein: 179-201
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

QLRSMGIGT-N--YLTGSLPPE-IGNL
.|..  ..  |   |||..||. . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAK-Un_bp-1.AA LRR_1 203-225 29 0.044748 11.53 Pfam 1-26 (26) Show / Hide
Range on Protein: 203-225
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

FLEQLYMDS-S--GLSGEIPPE-LGSL
 |. |....     |.|.|||. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAK-Un_bp-1.AA LRR_1 227-248 33 0.009728 13.88 Pfam 1-26 (26) Show / Hide
Range on Protein: 227-248
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

RLQILSISD-N--NFNGSVDV--LGNL
.||.|..|. |  |. |..    . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAK-Un_bp-1.AA LRR_1 250-272 33 0.011517 13.62 Pfam 1-26 (26) Show / Hide
Range on Protein: 250-272
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLQELTMEG-N--RFRGQLPSS-LGAL
.||.| . | |  .. |..|.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAK-Un_bp-1.AA LRR_1 298-319 37 0.002724 15.84 Pfam 1-26 (26) Show / Hide
Range on Protein: 298-319
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

LLSRLSLRNC---ELSGSIPD--FSNM
 | .|.|..|    |.|.||.  | |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL

LRR_1 IRAK-Un_bp-1.AA LRR_1 321-343 44 0.000227 19.67 Pfam 1-26 (26) Show / Hide
Range on Protein: 321-343
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

RLVFIDLSF-N--QLTGVIPSS-LASL
.|  .|||  |  .||| ||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL

Malectin IRAK-Un_bp-1.AA Malectin 387-573 40 1.4e-65 228.94 Pfam 1-202 (202) Show / Hide
Range on Protein: 387-573
Range on HMM: 1-202/202
Sequence Identity: 40% (83 aa)

FELSINCGGPAV---SADGMTFTEDSSSLSEAV---YYSNSSQSWAVSSTGYVDFNGNT------FNSVPTAATRVTGTRD--SSLYQTARASPTSLKYF
  . ||||||..   ..|| |.  |  .   ..   || .... |..| ||  ||....      . .. | ..... | |  . ||||.| || |..|.
YSWHINCGGPEHYTTDSDGITYEADNHFTGGSAASDYYVSRNNWWGYS-TG--DFMDDDNNQYYYG-YITTNSSIFYTTDDVDPELYQTERWSPSSFRYY

GLGMVNGPYQVDLHFAEIVIQDDSSGWTGLGRRFFDVYIQGSRVLQDFDIRAEANGSYIAIVRPF-PAQVSNNVLE--IHLLWRGRGTCCSPAP-LSFG-
.... || | | |||||| .||.. .|...||| ||||||| .||.||||..||.|.  |... | .. |.|..||  ||. | |.|||| |      | 
IPCLENGNYTVILHFAEIYFQDTDQTWNSPGRRVFDVYIQGKLVLKDFDIWKEAGGKGKAAHKEFINVTVTNGTLEYVIHFYWAGKGTCCIPFRKGYYGN

PLISAI
|.||||
PKISAI

Kinase IRAK-Un_bp-1.AA TKL 665-929 19 2e-63 217.03 In-house 1-364 (364) Show / Hide
Range on Protein: 665-929
Range on HMM: 1-364/364
Sequence Identity: 19% (74 aa)

LGQGGFGSVYKGVLPN---------GTIVAMKELSSKSNQG--------------------------TREFLNEVT-VISAVQHRNLVKLHGCCIEGSH-
.|.|||| ||||.. .         |. ||.| ..|....                            |.|..|.. ..|  .| |.|.. |.|..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RILIYEFLENNSLHQALLKPKERVIHFDWPTRFNICVGIARGIAYLHEESL-----PRIVHRDIKASNVLLDKTLN------------
              ...|. .. ||.  |.          |. |.... .||||..||| .       | |.|||.| .|.|.|. ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKIADFGLAKLFKDHQTHVSTR------------------VAGTIGYLSPEYAM----------------RGQLTEKADVYSFGVLVLEIVSGRDNLD
  .||.||||.. .. ..    |                   . ||.....||  .                 .. .||.||||||..  ||....    
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

TSLPTEMVYLLEWAWH----LYENNRPLELLDPEVPE--------FDEGEVLR-VIQVALLCSQALASARPTMSHAVAML
   | .     .. .     ..   . .. | |..|.         ..  ... ... .  | .. ...||...  .  |
---PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL

Kinase IRAK-Un_bp-1.AA IRAK 659-929 29 3.4e-61 209.62 In-house 1-317 (317) Show / Hide
Range on Protein: 659-929
Range on HMM: 1-317/317
Sequence Identity: 29% (93 aa)

FAPENKLGQGGFGSVYKGVLPNGT-IVAMK----ELSSKSNQGTREFLN---EVTVISAVQHRNLVKLHGCCIEGSHRILIYEFLENNSLHQALLKPKER
|...|..|.|||| ||.|.. | | |.| |    . ... |.  ..|.    |. | .  .| |.| | | |.|..   |.|... | ||.  |   .  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

VIH--FDWPTRFNICVGIARGIAYLHEES-LPRIVHRDIKASNVLLDKTLNPKIADFGLAKL--FKDHQTHVST------RVAGTIGYLSPEYAM--RGQ
.      |..|. || |.|.|| .||. .    | |.||| .|.|||. ..|||.||||.    .. |  . .       .| ||  |. ||.     ||
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTEKADVYSFGVLVLEIVSGR-DNLDTSLPTEMVYLLEWAWHLYENNRP--------------------------LELLDPEVPEFDEGEVLRVIQVALL
|| | ||||||. .||...|.   .| .  .|  ||..    . |  .                             ..|. .|  .. ...   |.|. 
LTKKTDVYSFGIVLLEVLTGCRAVYDDR--PEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACC

CSQALASARPTMSHAVAML
|  . |  |..|  ... |
CGHHRANRRCDMAWVMQQL

Kinase IRAK-Un_bp-1.AA Pkinase 659-858 25 5.8e-47 167.14 Pfam 1-209 (293) Show / Hide
Range on Protein: 659-858
Range on HMM: 1-209/293
Sequence Identity: 25% (56 aa)

FAPENKLGQGGFGSVYKGVLPNGTI-VAMKELSSKSNQG--TREFLN--EVTVISAVQHRNLVKLHGCCIEGSHRILIYEFLENN----SLHQALLK--P
.  . |.|.|.||.|||..  .  . ||.|... ...     .. ..  |. .   ..| | |.|.... ...|  .. |..|.     .|. ....   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYISTWR

KERVIHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKTLNP----KIADFGLAKLF-KDHQTHVSTRVAGTIGYLSPEYAM-RGQLTEK
. ... |.. .  ...  |.||..|.|..   .|.|||.| .|.|.|.. ..    ||.||||||.|   ...   | ..||..|..||  . .   . |
HGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPK

ADVYSFGVLVLEIVSGR
.|..|.|... | ..||
VDMWSCGCILYEMLCGR

Kinase IRAK-Un_bp-1.AA TK 659-856 17 1.4e-44 146.87 In-house 1-389 (486) Show / Hide
Range on Protein: 659-856
Range on HMM: 1-389/486
Sequence Identity: 17% (69 aa)

FAPENKLGQGGFG---SVYKGVLPNG--------------------------TIVAMKELSSKSNQGTRE--------------FLNEVTVISAVQ----
   ..|||.| ||    |||| . ..                          | || | | .....  .|              ||.|. ...  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVKLHGCCIEG------------SHRILIYEFLENNS----LHQALLKPKERVIH-----------------------------------------
 | |.|.|.|.| .|             . ... |. .. .    |.. | | ... .|                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FDWPTRFNICVGIARGIAYLHEESL---PRIVHRDIKASNVLLDKTLN-----------PKIADFGLAK
                               .. ...  .|. ||.| .|||.      ...||||. | |.|... ..            |||||||..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LFKDHQTHVSTRVAGTIG----------------------------YLSPEYAM---------RGQLTEKADVYSFGVLVLEIVS
     | .|.. .   ..... |                            ...||  .          |  |.| ||.|||||. ||..
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT

Kinase IRAK-Un_bp-1.AA TKL-Unique 661-857 30 9.4e-44 151.67 In-house 1-224 (290) Show / Hide
Range on Protein: 661-857
Range on HMM: 1-224/290
Sequence Identity: 30% (69 aa)

PENKLGQGGFGSVYKGVLPNGTIVAMKELSS---KSNQGTREFLNEVTVISAVQ-HRNLVKLHGCCI----EGSHRILIYEFLENNSLHQALL------K
. ||.|.||.|.||||.  .|..||.| ..    .||. ..|| |||....  . | |.|.. | |.      ...... |... .||.  |        
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

PKERVIHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKT-----LNPKIADFGLAKLFK-DHQTHVS-------TRVAGTIGYLSPEYA
  .. . ...  | ..   ||.|  ||| .. | | |||.| ||.|.|       .| ||.||||.|. . . .. ..       . . |.. ...||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

MR--GQLTEKADVYSFGVLVLEIVSG
..   | .||.||||||. . ||...
RMNFCQYSEKSDVYSFGIVLWEIATR

Kinase IRAK-Un_bp-1.AA Dicty4 659-848 33 9.8e-41 133.69 In-house 1-204 (277) Show / Hide
Range on Protein: 659-848
Range on HMM: 1-204/277
Sequence Identity: 33% (69 aa)

FAPENKLGQGGFGSVYKGVLPNGTIVAMKEL-SSKSN--QGT-REFLNEVTVISAVQHRNLVKLHGCCI----EGSHRILIYEFLENNSLHQALLK-PKE
 . |...|.|.||.||||    |..|| | | . . |  . .  ||..||.  .  .| |.... | |.    . .      |..   .|.  |.. | |
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--RVIHFDWPTRFN---ICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKTLNPKIADFGLAKLFKDHQTHVS--TRVAGTIGYLSPEYAMRGQLTEKA
    |  |||..     ..  .|||...||. . |.|.|||.|..| | || .. |..||||....| | .|    . ..|| .. .||  |    .|||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFG
||||||
DVYSFG

Kinase IRAK-Un_bp-1.AA MLK 659-858 25 1.4e-39 135.03 In-house 1-233 (291) Show / Hide
Range on Protein: 659-858
Range on HMM: 1-233/291
Sequence Identity: 25% (61 aa)

FAPENKLGQGGFGSVYKGVLPNGT----IVAMKELS------SKSNQGTREFLNEVTVISAVQHRN----LVKLHGCCIE-GSHRILIYEFLENNSLHQA
.  . ..| |.||.|.||.  | .    ||| |.        |..    ..|  |.   . ..|.|     ... |.|.. ..|  .. |..|. ||.  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

L--LKPKER--------VIHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLD------KTLNPKIADFGLAKLFKDH-QTHVSTRVAGTIG
|   ..|.          .  |    .|... .|||..|||..  . |.|||.| .|.|.|      . .. ||.|||... .... ... |.  |||  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSN--AGTYA

YLSPEY---AMRGQLTEKADVYSFGVLVLEIVSGR
. .||    .  .. .||.||.|.||.  |.....
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE

Kinase IRAK-Un_bp-1.AA Pkinase_Tyr 659-856 29 2.8e-38 130.26 Pfam 1-209 (270) Show / Hide
Range on Protein: 659-856
Range on HMM: 1-209/270
Sequence Identity: 29% (63 aa)

FAPENKLGQGGFGSVYKGVLP-----NGTIVAMKELSSKSNQG---TREFLNEVTVISAV-QHRNLVKLHGCCI-EGSH--RILIYEFLENNSLHQALLK
     |||.| ||.||||..      ... || | |  .. .     ..|..|. . .   .| |.|.|.|.|. .| .   ... |. .. .|.  | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

PKERVIHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKTLNPKIADFGLAKLF-KDHQT-HVSTRVAGTIGYLSPEYAMRGQLTEKADV
..|   ... ..  ..|. ||.| .||..     ..|||. | |.|.....  ||.|||||..  .| .  ....     |  ..||  . |  |.| ||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGVLVLEIVS
.|||||  ||..
WSFGVLMWEIFT

Kinase IRAK-Un_bp-1.AA LRRK 659-858 23 2e-37 129.92 In-house 1-279 (351) Show / Hide
Range on Protein: 659-858
Range on HMM: 1-279/351
Sequence Identity: 23% (67 aa)

FAPENKLGQGGFG-SVYKGVLPN---------------------------GTIVAMKELSSK---------SNQG-------------------------
.  |...|.|||| .||.. . .                           .. || | .            .. .                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

TREFLNEVTVISAVQHRNLVKLHGCCIEGSHRILIYEFLENNSLHQALLKPKERV-----IHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNV
 ||| .||...|  .| |.|.| | ||.  ..... |.. . .|.. | ..|.       .|..| ..  | . ||.|..|||  . | |.||| |  |.
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHN-PPIIHRDLKSPNI

LL---D---------KTLNPKIADFGLAKLFKDHQTHVSTRVAGTIGYLSPEYAMRG---QLTEKADVYSFGVLVLEIVSGR
||   .          . . ||||||.  .|.  .. |  .. |..|...||    .   . |||.|.||||..  |.....
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ

Kinase IRAK-Un_bp-1.AA TyrKc 659-929 24 2.2e-37 131.45 SMART 1-280 (280) Show / Hide
Range on Protein: 659-929
Range on HMM: 1-280/280
Sequence Identity: 24% (71 aa)

FAPENKLGQGGFGSVYKGVLPNGTIVAMKELSSKSNQGTREFLNEVTVISAV--QHRNLVKLHGCCIEG-------SHRILIYEFLENNSLHQALLKPKE
   . ||| | || ||||..   . || | | . .    ..|..|  . . .  .| |.|.|.|.|...           .. |. .. .|.. | |...
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RVIHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKTLNPKIADFGLAKLFKDH--------QTHV----STRVAGTIGYLSPEYAMRGQ
.   . ...  ..|. ||.| .|||.    ...|||. | |.|... .  ||.||||..  .|.          ..    ...    |  ..||  . | 
K---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

LTEKADVYSFGVLVLEIVSGRDNLDTSL---PTEMVYLLEWAWHLYENNRPLELLDPEVPEFDEGEVLRVIQVALLCSQALASARPTMSHAVAML
 |.| ||.||||.  || .  .         . .   ..|.  . |   .| . . | .  |  .    . |. . | .. .. |||.|  .  .
FTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQMMSNQEVIEYVKQGYRMPQPPNDY-P-MS-F-VCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF

Kinase IRAK-Un_bp-1.AA STE 659-858 21 1.9e-36 126.24 In-house 1-265 (359) Show / Hide
Range on Protein: 659-858
Range on HMM: 1-265/359
Sequence Identity: 21% (58 aa)

FAPENKLGQGGFGSVYKGVLPN----------------GTIVAMKELS----------------SKSNQGTR-EFLNEVTVISAVQ--HRNLVKLHGCCI
.    |.|.|.||.|||..  .                |.|.|.|...                ...|.  . ..|.|. . .  .  | | || .||..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------SHRILIYEFLENNSLHQALLKPKERVI----------HFDWPTRFNICVGIARG-IAYLHEESLPRIVHRDIKASNVLLDKTLNPKIADFG
 .       ..  .. |.... || . . . ...            .|. .    ||. | .|  .|||.     |.|||||..|.||      |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLFKDH-------------QTHVSTR--VAGTIGYLSPEYAMR------GQLTEKADVYSFGVLVLEIVSGR
... . |.             .| .. |  ..||  . .||  ..      .. ..|.|..|.| ...| . |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK

Kinase IRAK-Un_bp-1.AA S_TKc 659-929 22 2.8e-36 127.76 SMART 1-231 (231) Show / Hide
Range on Protein: 659-929
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

FAPENKLGQGGFGSVYKGVLPN-GTIVAMKELSSKSNQGTREFLNEVTVISAVQHRNLVKLHGCCIEGSHRILIYEFLEN--NSLHQALLKPKERVIH--
.   .|.|.|.||.|||..  . | |||.|...       . ...|. . .  .| |.|||.... . .|  .. |....   .|.. . | . .  .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKTLNPKIADFGLAKLFKDHQTHVSTRVAGTIGYLSPEYAMRGQLTE-KADVYSFGVLVL
|.  .   ..  |.....|.|  |. .|.|||.| .|.|||.  . ||.|||||...        | . ||  |..||     . .  |.|..|.|... 
FPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EIVSGRDNLDTSLPTEMVYLLEWAWHLYENNRPLELLDPEVPEFDEGEVLRVIQVALLCSQALASARPTMSHAVA---------ML
| ..|.   .   . .|  ..                              ...    | |   . |||   | .          .
EMLCGYPPFP--QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF

Kinase IRAK-Un_bp-1.AA TK-Unique 659-856 25 1.1e-34 117.04 In-house 1-234 (294) Show / Hide
Range on Protein: 659-856
Range on HMM: 1-234/294
Sequence Identity: 25% (60 aa)

FAPENKLGQGGFGSVYKGVLPNGT-------IVAMKELSSKSNQGT-REFLNEVTVISAVQ-HRNLVKLHGCCIEGS-HRILIYEFLENNSLHQALLKPK
.  ....|.| || |..| . ...       .|| | |  .... . ..||.|  . ...  | |.|.. |||.. .    .|.|.... .| | .|. .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNL-QHYLRTC

ERV-----------IHFDWPTRFN------------ICVGIARGIAYLHE--ESLPRIVHRDIKASNVLLDKTLNPKIADFGLAK-LFKDHQTHVS-TRV
 ..           . |. .....            ....||.| .||..  .     ||||. |.||||   .. ||.|||.|. . .....  . .. 
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI---VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

AGTIGYLSPEYAM--RGQL-TEKADVYSFGVLVLEIVS
   | ...||.    .|.  |.| ||.|||||  ||..
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT

Kinase IRAK-Un_bp-1.AA Dicty4-Unclassified 662-857 32 4.8e-34 113.98 In-house 4-204 (263) Show / Hide
Range on Protein: 662-857
Range on HMM: 4-204/263
Sequence Identity: 32% (68 aa)

ENKLGQGGFGSVYKGVLPNGTIVAMKELSSKSNQGT----REFLNEVTVISAVQHRNLVKLHGCCIEG-SHR---ILIYEFLENNSLHQALL-KP--KER
   .|.| |  |.||.   |  || | . . . .       .|. || .   .|| ||||. | ||   ||.   . . ||.    |      ||  ...
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

VIHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKTLNPKIADFGLAKLFKDHQTHVSTRVAGTIGYLSPEYAMRGQLTEKADVYSFGVL
 |  |      .   ||.|...||      ..|||||.||.|.||  | ||||||..      ..   | .|||    |||  |    . |.||||....
PIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNM--TTIAGTPKWESPECLMHESYNQKSDVYSYAMM

VLEIVSG
  | . |
LYELATG