Gene IRAK-Un_bp-2 (S.moellendorffii)

IRAK-Un_bp-2

Species: S.moellendorffii
Alias: IRAK-Un_bp-2
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAK-Unclassified

Sequence

Name Sequence Type Origin Length Description Download
IRAK-Un_bp-2.AA Protein None 992 None Fasta, JSON
IRAK-Un_bp-2.NA RNA None 2979 None Fasta, JSON
IRAK-Un_bp-2.kin_dom Protein Kinase Domain None 200 None Fasta, JSON

Protein domain

Protein domains of IRAK-Un_bp-2.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 IRAK-Un_bp-2.AA LRR_1 179-201 33 0.127303 9.92 Pfam 1-26 (26) Show / Hide 
Range on Protein: 179-201
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

QLRSMGIGT-N--YLTGSLPPE-IGNL
.|..  ..  |   |||..||. . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_bp-2.AA LRR_1 203-225 29 0.109641 10.15 Pfam 1-26 (26) Show / Hide 
Range on Protein: 203-225
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

FLEQLYMDS-S--GLSGEIPPQ-LESL
 |. |....     |.|.|||  . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_bp-2.AA LRR_1 227-248 37 0.003419 15.49 Pfam 1-26 (26) Show / Hide 
Range on Protein: 227-248
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

RLQILSISD-N--NFNGSIDV--LGNL
.||.|..|. |  |. |.|    . ||
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_bp-2.AA LRR_1 250-272 33 0.011517 13.62 Pfam 1-26 (26) Show / Hide 
Range on Protein: 250-272
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLQELTMEG-N--RFRGQLPSS-LGAL
.||.| . | |  .. |..|.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_bp-2.AA LRR_1 298-319 37 0.002724 15.84 Pfam 1-26 (26) Show / Hide 
Range on Protein: 298-319
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

LLSRLSLRNC---ELSGSIPD--FSNM
 | .|.|..|    |.|.||.  | |.
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAK-Un_bp-2.AA LRR_1 321-343 44 0.000227 19.67 Pfam 1-26 (26) Show / Hide 
Range on Protein: 321-343
Range on HMM: 1-26/26
Sequence Identity: 44% (12 aa)

RLVFIDLSF-N--QLTGVIPSS-LASL
.|  .|||  |  .||| ||.| . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Malectin IRAK-Un_bp-2.AA Malectin 387-573 40 1.9e-66 231.89 Pfam 1-202 (202) Show / Hide 
Range on Protein: 387-573
Range on HMM: 1-202/202
Sequence Identity: 40% (84 aa)

FELSINCGGPAV---SADGMTFTEDSSSLSEAV---YYSNSSQSWAVSSTGYVDFNGNT------FNSVPTAATRVTGTRD--SSLYQTARASPTSLKYF
  . ||||||..   ..|| |.  |  .   ..   || .... |..| ||  ||....      . .. | ..... | |  . ||||.| || |..|.
YSWHINCGGPEHYTTDSDGITYEADNHFTGGSAASDYYVSRNNWWGYS-TG--DFMDDDNNQYYYG-YITTNSSIFYTTDDVDPELYQTERWSPSSFRYY

GLGMVNGPYQVDLHFAEIVIQDDSSGWTGLGRRFFDVYIQGSRVLQDFDIRAEANGSYIAIVRPF-PAQVSNNVLE--IHLLWRGKGTCCSPAP-LSFG-
.... || | | |||||| .||.. .|...||| ||||||| .||.||||..||.|.  |... | .. |.|..||  ||. | |||||| |      | 
IPCLENGNYTVILHFAEIYFQDTDQTWNSPGRRVFDVYIQGKLVLKDFDIWKEAGGKGKAAHKEFINVTVTNGTLEYVIHFYWAGKGTCCIPFRKGYYGN

PLISAI
|.||||
PKISAI
Kinase IRAK-Un_bp-2.AA TKL 665-929 19 4.8e-64 219.09 In-house 1-364 (364) Show / Hide 
Range on Protein: 665-929
Range on HMM: 1-364/364
Sequence Identity: 19% (73 aa)

LGQGGFGSVYKGVLPN---------GTIVAMKELSSKSNQG--------------------------TREFLNEVT-VISAVQHRNLVKLHGCCIEGSH-
.|.|||| ||||.. .         |. ||.| ..|....                            |.|..|.. ..|  .| |.|.. |.|..... 
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

------------RILIYEFLENNSLHQALLKPKERVIHFDWPTRFNICVGIARGIAYLHEESL-----PRIVHRDIKASNVLLDKTLN------------
              ...|. .. ||.  |.          |. |.... .||||..||| .       | |.|||.| .|.|.|. ..            
CVCMHPVGPWGQLCIVMEYCPGGSLLHYLH----------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKSKNILVDENWTNVSNYMYNPNAD

--PKIADFGLAKLFKDHQTHVSTR------------------VAGTIGYLSPEYAM----------------RGQLTEKADVYSFGVLVLEVVSGRDNLD
  .||.||||.. .. ..    |                   . ||.....||  .                 .. .||.||||||..  |.....    
WCCKICDFGLSRFMSQSGNMNDTMTTMMESAEHQNNRKTTMTQCGTPRWMAPEVLRGQMNYTEKVGIDEFCKGFEYSEKCDVYSFGIVLWEILTRCR---

TSLPTEMIYLLEWAWH----LHENNRALELLDPEVPE--------FDEGEVLR-VIQVALLCSQALASARPTMSHAVAML
   | . .   .. .     .    .... | |..|.         ..  ... ... .  | .. ...||...  .  |
---PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHDPEKRPSFQEILKRL
Kinase IRAK-Un_bp-2.AA IRAK 659-929 29 2.2e-62 213.54 In-house 1-317 (317) Show / Hide 
Range on Protein: 659-929
Range on HMM: 1-317/317
Sequence Identity: 29% (92 aa)

FAPENKLGQGGFGSVYKGVLPNGT-IVAMK----ELSSKSNQGTREFLN---EVTVISAVQHRNLVKLHGCCIEGSHRILIYEFLENNSLHQALLKPKER
|...|..|.|||| ||.|.. | | |.| |    . ... |.  ..|.    |. | .  .| |.| | | |.|..   |.|... | ||.  |   .  
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTERQCHCLVYPYMPNGSLEDRLWCQDGQ

VIH--FDWPTRFNICVGIARGIAYLHEES-LPRIVHRDIKASNVLLDKTLNPKIADFGLAKL--FKDHQTHVST------RVAGTIGYLSPEYAM--RGQ
.      |..|. || |.|.|| .||. .    | |.||| .|.|||. ..|||.||||.    .. |  . .       .| ||  |. ||.     ||
CPPKPLSWHQRCSICWGTACGIQFLHQNHPCTPIIHGDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQ

LTEKADVYSFGVLVLEVVSGR-DNLDTSLPTEMIYLLEWAWHLHENN--------------------RAL----ELLDPEVPEFDEGEVLRVIQVALLCS
|| | ||||||. .|||..|.   .| . ... . .|       ..                     |..     ..|. .|  .. ...   |.|. | 
LTKKTDVYSFGIVLLEVLTGCRAVYDDRPEHYYLKDLCEEIMEEWGHLDSCQSTLWVGVATDAWAAPRRMQIYEKFIDHRMPPCPPNMEKEMCQCACCCG

QALASARPTMSHAVAML
 . |  |..|  ... |
HHRANRRCDMAWVMQQL
Kinase IRAK-Un_bp-2.AA Pkinase 659-858 25 3.5e-47 167.87 Pfam 1-209 (293) Show / Hide 
Range on Protein: 659-858
Range on HMM: 1-209/293
Sequence Identity: 25% (56 aa)

FAPENKLGQGGFGSVYKGVLPNGTI-VAMKELSSKSNQG--TREFLN--EVTVISAVQHRNLVKLHGCCIEGSHRILIYEFLENN----SLHQALLK--P
.  . |.|.|.||.|||..  .  . ||.|... ...     .. ..  |. .   ..| | |.|.... ...|  .. |..|.     .|. ....   
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFEDKDHIYMVMEYCEGGLYVMDLF-DYISTWR

KERVIHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKTLNP----KIADFGLAKLF-KDHQTHVSTRVAGTIGYLSPEYAM-RGQLTEK
. ... |.. .  ...  |.||..|.|..   .|.|||.| .|.|.|.. ..    ||.||||||.|   ...   | ..||..|..||  . .   . |
HGCFY-FSEWECKFYMYQILRGLEYCHSM---GIIHRDLKPENILIDNNGHIDACVKICDFGLAKQFDY-NNS--MTTFCGTPWYMAPEVIRGGQYYGPK

ADVYSFGVLVLEVVSGR
.|..|.|... |...||
VDMWSCGCILYEMLCGR
Kinase IRAK-Un_bp-2.AA TK 659-856 17 3.4e-44 145.58 In-house 1-389 (486) Show / Hide 
Range on Protein: 659-856
Range on HMM: 1-389/486
Sequence Identity: 17% (68 aa)

FAPENKLGQGGFG---SVYKGVLPNG--------------------------TIVAMKELSSKSNQGTRE--------------FLNEVTVISAVQ----
   ..|||.| ||    |||| . ..                          | || | | .....  .|              ||.|. ...  .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

-HRNLVKLHGCCIEG------------SHRILIYEFLENNS----LHQALLKPKERVIH-----------------------------------------
 | |.|.|.|.| .|             . ... |. .. .    |.. | | ... .|                                         
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYLRKCRPKFQHEQDCPDNQHNKYPPSKLHHCMKGDITYSHESNSPCPEEQDY

-------------------------------FDWPTRFNICVGIARGIAYLHEESL---PRIVHRDIKASNVLLDKTLN-----------PKIADFGLAK
                               .. ...  .|. ||.| .|||.      ...||||. | |.|... ..            |||||||..
DDDLIKDHPPPLTTKDLLQMAWQWCLTCKHQLTMHQLL-MCWQIACGMEYLHSKNCEFIQNFVHRDLAARNCLVGENNVCKWHFDGCGPVCKIADFGLSR

-----LFKDHQTHVSTRVAGTIG----------------------------YLSPEYAM---------RGQLTEKADVYSFGVLVLEVVS
     | .|.. .   ..... |                            ...||  .          |  |.| ||.|||||. |...
QGSGVLARDIYSDDDYYRKSSYGTGRPMWPFEDDPWQDYYRQQSGGKLPIRWMAPECLNDRVFSEAEKYGKFTTKSDVWSFGVLMWEIFT
Kinase IRAK-Un_bp-2.AA TKL-Unique 661-857 30 1.2e-42 147.95 In-house 1-224 (290) Show / Hide 
Range on Protein: 661-857
Range on HMM: 1-224/290
Sequence Identity: 30% (68 aa)

PENKLGQGGFGSVYKGVLPNGTIVAMKELSS---KSNQGTREFLNEVTVISAVQ-HRNLVKLHGCCI----EGSHRILIYEFLENNSLHQALL------K
. ||.|.||.|.||||.  .|..||.| ..    .||. ..|| |||....  . | |.|.. | |.      ...... |... .||.  |        
FWNKIGEGGYGQVYKGKW-RGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQVYPPNMCIVMEYCPGGSLYDVLHQNNNNNN

PKERVIHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKT-----LNPKIADFGLAKLFK-DHQTHVS-------TRVAGTIGYLSPEYA
  .. . ...  | ..   ||.|  ||| .. | | |||.| ||.|.|       .| ||.||||.|. . . .. ..       . . |.. ...||  
NNNNNCKLNMQQRVKMAIDIAQGMYYLHHCEPP-IIHRDLKSSNFLVDNNSNIAEWNIKICDFGLSKFNSKINKMTNNEHKGTRNQTRCGSFRWMAPEVL

MR--GQLTEKADVYSFGVLVLEVVSG
..   | .||.||||||. . | ...
RMNFCQYSEKSDVYSFGIVLWEIATR
Kinase IRAK-Un_bp-2.AA Dicty4 659-848 33 9.8e-41 133.69 In-house 1-204 (277) Show / Hide 
Range on Protein: 659-848
Range on HMM: 1-204/277
Sequence Identity: 33% (69 aa)

FAPENKLGQGGFGSVYKGVLPNGTIVAMKEL-SSKSN--QGT-REFLNEVTVISAVQHRNLVKLHGCCI----EGSHRILIYEFLENNSLHQALLK-PKE
 . |...|.|.||.||||    |..|| | | . . |  . .  ||..||.  .  .| |.... | |.    . .      |..   .|.  |.. | |
INIEQRIGKGSFGEVYKGTW-RGKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACTAPRSHPGKMCIVTEYMPKGNLYSLLHDKPSE

--RVIHFDWPTRFN---ICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKTLNPKIADFGLAKLFKDHQTHVS--TRVAGTIGYLSPEYAMRGQLTEKA
    |  |||..     ..  .|||...||. . |.|.|||.|..| | || .. |..||||....| | .|    . ..|| .. .||  |    .|||
QQQSIKLDWPLIKRAMRMAFDAARGMNWLHC-CNPVIIHRDLKSHNLLVDKNWRVKVCDFGLSQYMKKHEDHKDNQMTACGTPCWMAPEVMMHQPYNEKA

DVYSFG
||||||
DVYSFG
Kinase IRAK-Un_bp-2.AA MLK 659-858 25 2.7e-39 134.02 In-house 1-233 (291) Show / Hide 
Range on Protein: 659-858
Range on HMM: 1-233/291
Sequence Identity: 25% (61 aa)

FAPENKLGQGGFGSVYKGVLPNGT----IVAMKELS------SKSNQGTREFLNEVTVISAVQHRN----LVKLHGCCIE-GSHRILIYEFLENNSLHQA
.  . ..| |.||.|.||.  | .    ||| |.        |..    ..|  |.   . ..|.|     ... |.|.. ..|  .. |..|. ||.  
IQFHEWIGSGSFGKVWKGRWRNKDIVAKIVAVKRVRARIFDKSDTYCEQWDFEMECRHLRILSHPNNHPCIIQFYGVCLQPPCHFCIVMEYCEGGSLYNV

L--LKPKER--------VIHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLD------KTLNPKIADFGLAKLFKDH-QTHVSTRVAGTIG
|   ..|.          .  |    .|... .|||..|||..  . |.|||.| .|.|.|      . .. ||.|||... .... ... |.  |||  
LHGARSKWMDANHNQKNDRVYDHDHAMNWALQCARGMHYLHSMAPKPIIHRDLKSHNILIDEICHDMHHGTLKICDFGTSRDWHQMCTNMMSN--AGTYA

YLSPEY---AMRGQLTEKADVYSFGVLVLEVVSGR
. .||    .  .. .||.||.|.||.  |.....
WMAPEVIQQFRCEKYSEKCDVWSWGVVLWEMLTRE
Kinase IRAK-Un_bp-2.AA Pkinase_Tyr 659-856 29 1e-37 128.39 Pfam 1-209 (270) Show / Hide 
Range on Protein: 659-856
Range on HMM: 1-209/270
Sequence Identity: 29% (62 aa)

FAPENKLGQGGFGSVYKGVLP-----NGTIVAMKELSSKSNQG---TREFLNEVTVISAV-QHRNLVKLHGCCI-EGSH--RILIYEFLENNSLHQALLK
     |||.| ||.||||..      ... || | |  .. .     ..|..|. . .   .| |.|.|.|.|. .| .   ... |. .. .|.  | |
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCTDQGEPNQIYIVMEYMPHGDLLDYLRK

PKERVIHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKTLNPKIADFGLAKLF-KDHQT-HVSTRVAGTIGYLSPEYAMRGQLTEKADV
..|   ... ..  ..|. ||.| .||..     ..|||. | |.|.....  ||.|||||..  .| .  ....     |  ..||  . |  |.| ||
HREDKQPLTMKDLLQMCWQIAKGMEYLESKN---CIHRDLAARNCLVTENNVVKICDFGLARDIYNDDYYYRKRGGGKLPIKWMAPECINYGKFTTKSDV

YSFGVLVLEVVS
.|||||  |...
WSFGVLMWEIFT
Kinase IRAK-Un_bp-2.AA LRRK 659-858 23 1.9e-36 126.43 In-house 1-279 (351) Show / Hide 
Range on Protein: 659-858
Range on HMM: 1-279/351
Sequence Identity: 23% (67 aa)

FAPENKLGQGGFG-SVYKGVLPN---------------------------GTIVAMKELSSK---------SNQG-------------------------
.  |...|.|||| .||.. . .                           .. || | .            .. .                         
LKIEEQIGRGGFGTFVYRAKWRGQPVHVCRMHQKMLQPYMYQGARNSYDMCQWVAIKKWNRDPMTIDNDCNNSNNNNNLNNNNSEQVEDMDQNHEDCCRA

TREFLNEVTVISAVQHRNLVKLHGCCIEGSHRILIYEFLENNSLHQALLKPKERV-----IHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNV
 ||| .||...|  .| |.|.| | ||.  ..... |.. . .|.. | ..|.       .|..| ..  | . ||.|..|||  . | |.||| |  |.
FREFRHEVWIMSHLNHPNIVSLKGFCIH--PLCMVMEYAPHGDLYHFLHNKKQDGFHFMKAHISWMLKLKIALQIAKGMEYLHSHN-PPIIHRDLKSPNI

LL---D---------KTLNPKIADFGLAKLFKDHQTHVSTRVAGTIGYLSPEYAMRG---QLTEKADVYSFGVLVLEVVSGR
||   .          . . ||||||.  .|.  .. |  .. |..|...||    .   . |||.|.||||..  | ....
LLWSSPQNHSPNYPNAHVCAKIADFGISRMFQCFHMGVAKGCVGNPGWMAPEIMRYNGEEEYTEKVDCYSFGMILWELLTRQ
Kinase IRAK-Un_bp-2.AA S_TKc 659-929 22 5.8e-36 126.71 SMART 1-231 (231) Show / Hide 
Range on Protein: 659-929
Range on HMM: 1-231/231
Sequence Identity: 22% (63 aa)

FAPENKLGQGGFGSVYKGVLPN-GTIVAMKELSSKSNQGTREFLNEVTVISAVQHRNLVKLHGCCIEGSHRILIYEFLEN--NSLHQALLKPKERVIH--
.   .|.|.|.||.|||..  . | |||.|...       . ...|. . .  .| |.|||.... . .|  .. |....   .|.. . | . .  .  
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD-DHLYMVMEYCDGDLGDLFDYIKKRGRHGLRFP

FDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKTLNPKIADFGLAKLFKDHQTHVSTRVAGTIGYLSPEYAMRGQLTE-KADVYSFGVLVL
|.  .   ..  |.....|.|  |. .|.|||.| .|.|||.  . ||.|||||...        | . ||  |..||     . .  |.|..|.|... 
FPE-HARFYMYQICCALEYCH--SH-GIIHRDLKPENILLDE--HIKICDFGLARQL--------TTFCGTPWYMAPEVL---GYGKCKCDWWSCGCILY

EVVSGRDNLDTSLPTEMIYLLEWAWHLHENNRALELLDPEVPEFDEGEVLRVIQVALLCSQALASARPTMSHAVA---------ML
| ..|.   .   . .|. ..                              ...    | |   . |||   | .          .
EMLCGYPPFP--QMQMMFKKIG--------------------------SPEAKDFIRKCLQKDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAK-Un_bp-2.AA STE 659-858 21 7.5e-36 124.1 In-house 1-265 (359) Show / Hide 
Range on Protein: 659-858
Range on HMM: 1-265/359
Sequence Identity: 21% (58 aa)

FAPENKLGQGGFGSVYKGVLPN----------------GTIVAMKELS----------------SKSNQGTR-EFLNEVTVISAVQ--HRNLVKLHGCCI
.    |.|.|.||.|||..  .                |.|.|.|...                ...|.  . ..|.|. . .  .  | | || .||..
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

EG-------SHRILIYEFLENNSLHQALLKPKERVI----------HFDWPTRFNICVGIARG-IAYLHEESLPRIVHRDIKASNVLLDKTLNPKIADFG
 .       ..  .. |.... || . . . ...            .|. .    ||. | .|  .|||.     |.|||||..|.||      |..|||
KEGHNHKNDDELWICMEYMDGGSLDDIIKHKYGCGKPLNHNRQHQHRFPESQIAYICRQILKGLLYYLHSHH---IIHRDIKPANILL-----VKLCDFG

LAKLFKDH-------------QTHVSTR--VAGTIGYLSPEYAMR------GQLTEKADVYSFGVLVLEVVSGR
... . |.             .| .. |  ..||  . .||  ..      .. ..|.|..|.| ...| . |.
VCGQLTDSMANIQSNNIIDCIETMQQKRNTFVGTP-WMAPEVIQQNGQGRDKGYDTKCDIWSLGCTIIEMATGK
Kinase IRAK-Un_bp-2.AA TyrKc 659-929 22 1.6e-34 121.94 SMART 1-280 (280) Show / Hide 
Range on Protein: 659-929
Range on HMM: 1-280/280
Sequence Identity: 22% (68 aa)

FAPENKLGQGGFGSVYKGVLPNGTIVAMKELSSKSNQGTREFLNEVTVISAV--QHRNLVKLHGCCIEG-------SHRILIYEFLENNSLHQALLKPKE
   . ||| | || ||||..   . || | | . .    ..|..|  . . .  .| |.|.|.|.|...           .. |. .. .|.. | |...
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRNFMYIEPLMIVMEYMPHGDLKDYLRKHRP

RVIHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKTLNPKIADFGLAKLFKDH--------QTHV----STRVAGTIGYLSPEYAMRGQ
.   . ...  ..|. ||.| .|||.    ...|||. | |.|... .  ||.||||..  .|.          ..    ...    |  ..||  . | 
K---LCMKDLLSFCWQIACGMEYLHSK---NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQGESKDYYRKKEHKGGKTMLPIRWMAPECINYGK

LTEKADVYSFGVLVLEVVSGRDNLDTSLPTEMIYLLEWAWHLHENNRALELLDPE-VPEFDEG--------EVLRVIQVALLCSQALASARPTMSHAVAM
 |.| ||.||||.  |. .           .. |  .      .| ...|...    ..  .             . |. . | .. .. |||.|  .  
FTTKSDVWSFGVCMWEIFTY---------GQQPYPGMIQQ-MMSNQEVIEYVKQGYRMPQPPNDYPMSFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHEC

L
.
F
Kinase IRAK-Un_bp-2.AA TK-Unique 659-856 24 5.3e-34 114.67 In-house 1-234 (294) Show / Hide 
Range on Protein: 659-856
Range on HMM: 1-234/294
Sequence Identity: 24% (59 aa)

FAPENKLGQGGFGSVYKGVLPNGT-------IVAMKELSSKSNQGT-REFLNEVTVISAVQ-HRNLVKLHGCCIEGS-HRILIYEFLENNSLHQALLKPK
.  ....|.| || |..| . ...       .|| | |  .... . ..||.|  . ...  | |.|.. |||.. .    .|.|.... .| | .|. .
LEVGDVIGEGAFGQVWRGEVWGIWKHWDKQKCVAVKMLKDNATDTDKQDFLKEIQMMKELGDHPNIVQCLGCCTKSDEPWMIIMEYCPCGNL-QHYLRTC

ERV-----------IHFDWPTRFN------------ICVGIARGIAYLHE--ESLPRIVHRDIKASNVLLDKTLNPKIADFGLAK-LFKDHQTHVS-TRV
 ..           . |. .....            ....||.| .||..  .     ||||. |.||||   .. ||.|||.|. . .....  . .. 
RPAMRQHQTYGNLKFDFHHMPDKPRTEPISPKDLYHFAWQIACGMEYLASQRKKI---VHRDLCARNVLLTEDKVCKICDFGMARDVYTNGVYSMMCSQG

AGTIGYLSPEYAM--RGQL-TEKADVYSFGVLVLEVVS
   | ...||.    .|.  |.| ||.|||||  |...
RIPIRWMAPESLKCYHGMYHTTKSDVWSFGVLMWEIFT
Kinase IRAK-Un_bp-2.AA Dicty4-Unclassified 662-857 32 6.5e-34 113.5 In-house 4-204 (263) Show / Hide 
Range on Protein: 662-857
Range on HMM: 4-204/263
Sequence Identity: 32% (68 aa)

ENKLGQGGFGSVYKGVLPNGTIVAMKELSSKSNQGT----REFLNEVTVISAVQHRNLVKLHGCCIEG-SHR---ILIYEFLENNSLHQALL-KP--KER
   .|.| |  |.||.   |  || | . . . .       .|. || .   .|| ||||. | ||   ||.   . . ||.    |      ||  ...
DQFIGKGHFSKVHKGNW-KGKDVAVKKFNENKFKFREEMIQDFKKEVEILGSIQHPNLVKCYGYCINPRSHKSTMCIVMEFMHKGNLFEVIHSKPSEQQQ

VIHFDWPTRFNICVGIARGIAYLHEESLPRIVHRDIKASNVLLDKTLNPKIADFGLAKLFKDHQTHVSTRVAGTIGYLSPEYAMRGQLTEKADVYSFGVL
 |  |      .   ||.|...||      ..|||||.||.|.||  | ||||||..      ..   | .|||    |||  |    . |.||||....
PIKLDDTLIIKYAFDIAQGMQHLHTRN---FIHRDIKSSNILMDKHFNIKIADFGISRVIDFNFNM--TTIAGTPKWESPECLMHESYNQKSDVYSYAMM

VLEVVSG
  | . |
LYELATG