Gene IRAKd_a (S.moellendorffii)

IRAKd_a

Species: S.moellendorffii
Alias: IRAKd_a
External Links:
Annotation:

Classification

Group: TKL
Family: IRAK
Subfamily: IRAKd

Sequence

Name Sequence Type Origin Length Description Download
IRAKd_a.AA Protein None 1917 None Fasta, JSON
IRAKd_a.NA RNA None 5754 None Fasta, JSON
IRAKd_a.kin_dom Protein Kinase Domain None 229 None Fasta, JSON

Protein domain

Protein domains of IRAKd_a.AA. The domains are annotated by HMM profiles from Pfam and SMART, as well as in-house data which includes HMMs of each individual kinase group, family and subfamily. Here is domain list in details, including sequence identity, significance and alignment. In particular, you can find can find the best hit kinase group/family/subfamily, which is helpful to understand the relationship between kinases.Kinase domain and best hit kinase group/family/subfamily are highlighted in red and blue. Visualized by pviz.

Usage: Zoom in selected region by dragging mouse and zoom out by double-clicking.

Show/hide domain list
Domain Protein name Domain Name Range Identity (%) Significance Score Profile Source Profile Range (length) Alignment
LRR_1 IRAKd_a.AA LRR_1 138-160 33 0.000151 20.29 Pfam 1-26 (26) Show / Hide 
Range on Protein: 138-160
Range on HMM: 1-26/26
Sequence Identity: 33% (9 aa)

SLRVLDLSE-N--SISGALPDR-LRAL
.|..||||  |  ...| .|.. . .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP IRAKd_a.AA LRR_TYP 136-160 40 0.032655 12.03 SMART 1-24 (24) Show / Hide 
Range on Protein: 136-160
Range on HMM: 1-24/24
Sequence Identity: 40% (10 aa)

LQSLRVLDLSENSISGALPDRLRAL
| .||.|||| | .  .||... . 
LPNLRELDLSNNQL-THLPPGAFQG
LRR_1 IRAKd_a.AA LRR_1 186-209 40 0.00013 20.52 Pfam 1-26 (26) Show / Hide 
Range on Protein: 186-209
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLRELDLSN-N--AITGKLPKSLFSSR
.|..||||. |   .||..|.| | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP IRAKd_a.AA LRR_TYP 184-208 56 0.000298 21.37 SMART 1-24 (24) Show / Hide 
Range on Protein: 184-208
Range on HMM: 1-24/24
Sequence Identity: 56% (14 aa)

LRSLRELDLSNNAITGKLPKSLFSS
|..|||||||||..|  ||  .|..
LPNLRELDLSNNQLT-HLPPGAFQG
LRR_1 IRAKd_a.AA LRR_1 162-184 29 0.019489 12.81 Pfam 1-26 (26) Show / Hide 
Range on Protein: 162-184
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

RLEILQLKD-N--RLNGTLPGW-IGEL
.|..| | . |  .| |..| . .  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKd_a.AA LRR_1 212-235 25 0.009176 13.97 Pfam 1-26 (26) Show / Hide 
Range on Protein: 212-235
Range on HMM: 1-26/26
Sequence Identity: 25% (7 aa)

RLERLVVSH-N--DFSGNLPDWSSDSL
.|..| .|. |   ..|..|...  .|
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_TYP IRAKd_a.AA LRR_TYP 281-304 41 0.058753 9.94 SMART 1-24 (24) Show / Hide 
Range on Protein: 281-304
Range on HMM: 1-24/24
Sequence Identity: 41% (10 aa)

LGGVRTMDLSYNELHGMPPAALFR
|.  |. |||.| |   || |.  
LPNLRELDLSNNQLTHLPPGAFQG
LRR_1 IRAKd_a.AA LRR_1 258-281 37 0.875876 6.95 Pfam 1-26 (26) Show / Hide 
Range on Protein: 258-281
Range on HMM: 1-26/26
Sequence Identity: 37% (10 aa)

LLQSLLLGQ-N--DITGGIPHDAAARL
 ||.| |.  |   .|| ||...   |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKd_a.AA LRR_1 283-305 29 1.482084 6.14 Pfam 1-26 (26) Show / Hide 
Range on Protein: 283-305
Range on HMM: 1-26/26
Sequence Identity: 29% (8 aa)

GVRTMDLSY-N--ELH-GMPPAALFRL
  .. |||. |   |    || ..  |
NLQHLDLSGCNCCNLTGHIPPSCF-NL
LRR_1 IRAKd_a.AA LRR_1 307-326 30 2.132042 5.58 Pfam 1-26 (26) Show / Hide 
Range on Protein: 307-326
Range on HMM: 1-26/26
Sequence Identity: 30% (8 aa)

HIETLALNG-N--QFLGVLPY---NL
....| |.| |  .. | .|    ||
NLQHLDLSGCNCCNLTGHIPPSCFNL
LRR_1 IRAKd_a.AA LRR_1 331-353 40 0.051957 11.3 Pfam 1-26 (26) Show / Hide 
Range on Protein: 331-353
Range on HMM: 1-26/26
Sequence Identity: 40% (11 aa)

SLALLDLSS-N--FFTGRVPAS-FLGS
.|  ||||. |   .|| .| | | . 
NLQHLDLSGCNCCNLTGHIPPSCF-NL
Kinase IRAKd_a.AA TKL 500-667 18 4.7e-27 94.46 In-house 1-200 (364) Show / Hide 
Range on Protein: 500-667
Range on HMM: 1-200/364
Sequence Identity: 18% (44 aa)

IGEGQHGKVFKGKLHD---------GTVAAVKCLTL---------------------------DSRQDMRQLKIHVELLVKIRHRHLVGYIG--------
||.|  |.|.|||..          |.. ||| .                             .... . ...  . .. ..|| ..| ..|        
IGSGGFGEVYKGKWRGWGGKCPSDTGKDVAVKKFKSHNDDEFTKNSQENNDNNNYSDMQLNDPEASWFRFFEEEEIMMMSRLRHPNIVQFMGYCCCPPCG

-YSLDNVIDGARQCRKLYLVSEYIDNGTLRNHLSSKFVTGLLGLMFCFSDLPVEAEGREVLSWSQRLAAAIGAGRGIQYLHTGVV-----PGIFNNDVNI
 .....|     .. .|..| ||...|.|...|                             |.||.  |... ||..|||.        |.|   | . 
CVCMHPV----GPWGQLCIVMEYCPGGSLLHYLH----------------------------WHQRCRWALDIARGMNYLHSMNPKWCTKPPIIHRDLKS

TNVLMDQN--------------CVAKFTDFGI
 |.| |.|              ...| .|||.
KNILVDENWTNVSNYMYNPNADWCCKICDFGL
Kinase IRAKd_a.AA TK 494-587 16 6.2e-13 38.93 In-house 1-150 (486) Show / Hide 
Range on Protein: 494-587
Range on HMM: 1-150/486
Sequence Identity: 16% (24 aa)

FSLENLIGEGQHG---KVFKGKLHDG--------------------------TVAAVKCLTLDSRQDMRQLKI----------------HVELLVK---I
  |.. .|||| |   .|.||.....                          |  |||.|.... ..... .                 ... . .    
ITLGKKLGEGQFGSFGEVYKGEWRGRNPWNGKRFPCHMTVTLKCKNGKEGGKTPVAVKMLKEGDAMSQEEFFDEEMHDRDGGEDFLEEAEEMKMMCHSLG

RHRHLVGYIGYSLDNVIDGARQ----CRKLYLVSEYIDNGT----LRNHL
.| ..|  .|......           . ...| || ..|     ||..|
HHPNIVRLYGVCTQGEPKPCFEVVVHQEPWMIVMEYMPHGDMDGSLRDYL
Kinase IRAKd_a.AA STE 494-594 19 1e-12 41.36 In-house 1-135 (359) Show / Hide 
Range on Protein: 494-594
Range on HMM: 1-135/359
Sequence Identity: 19% (26 aa)

FSLENLIGEGQHGKVFKGKLHD----------------GTVAAVKCLTLDS-----------------RQDMRQLKIHVELLVKIR--HRHLVGYIGYSL
. .   ||.|  |.|.|.. |.                |.. |.| . |..                  ..| |..  .... | .  | . | |.|. .
WEGIEKIGKGAFGTVYKAMNHKNCNIHKTGEVENNGETGEIMAIKQMNLENCNNKDENQENQELENKNHEEMQQILKEIKIMKKCNHMHPNIVKYYGCYF

DNVIDGARQCRKLYLVSEYIDNGTLRNHLSSKFVTG
..  .   .. .|... ||.|.|.|.  . .|. .|
KEGHN-HKNDDELWICMEYMDGGSLDDIIKHKYGCG
Kinase IRAKd_a.AA TyrKc 494-789 17 1.4e-12 -19.42 SMART 1-280 (280) Show / Hide 
Range on Protein: 494-789
Range on HMM: 1-280/280
Sequence Identity: 17% (58 aa)

FSLENLIGEGQHGKVFKGKLHDGTVAAVKCLTLDSRQDMRQLKIHVELLVKI--RHRHLVGYIGYSLD---NVIDGARQC---RKLYLVSEYIDNGTLRN
 .|.  .|||. |.|.||..   .  |||.|  |.   .. .    ... |.  .| ..|  .|. ..   |             |..| || ..| |..
ITLGKKLGEGAFGEVYKGTWK--IQVAVKMLKEDA---REDFMREARIMCKLGGHHPNIVRLYGVCTQQGRN-------FMYIEPLMIVMEYMPHGDLKD

HLSSKFVTGLLGLMFCFSDLPVEAEGREVLSWSQRLAAAIGAGRGIQYLHTGVVPGIFNNDVNIT-------NVLMDQNCVAKFTDFGIGKHARTS---C
.| ..  .                     |.... |  .. . .| .|||            |.        |.| . | ..| .|||  .         
YLRKHRPK---------------------LCMKDLLSFCWQIACGMEYLHSK----------NCIHRDLAARNCLVGENHTVKISDFGLSRDIYDDDQQG

DFDAKVYVQKT--PAH------------IDLDHHRRKLASDKTDVYNFGFILLEIL-LGKPPTIEDSKSSVHPKEMLQTEHVPRYEVVDPAIIGNCVAE-
    ..|..|.   ..            |     . .  . |.||. ||  . ||. .|..|  .. .    ...  .  .  .     |    ..  . 
-ESKDYYRKKEHKGGKTMLPIRWMAPECI-----NYGKFTTKSDVWSFGVCMWEIFTYGQQPYPGMIQQ---MMSNQEVIEYVKQGYRMPQPPNDY--PM

----SLTTVLEIAAKCLSEEPSSRPSMEDVLWNL
      . . .|  .|  |.|..||.....   .
SFVCCPDEMYQIMKQCWHEDPEDRPTFSEIHECF
Kinase IRAKd_a.AA IRAK 615-722 32 1.4e-12 41.07 In-house 106-223 (317) Show / Hide 
Range on Protein: 615-722
Range on HMM: 106-223/317
Sequence Identity: 32% (39 aa)

LSWSQRLAAAIGAGRGIQYLHTGV--VPGIFNNDVNITNVLMDQNCVAKFTDFGIGKHA-RTSCDFDAKV------YVQKTPAHIDLDHHR---RKLASD
||| ||.  ..|...|||.||.    .| |   |.   |.| ||. ..| .|||   .   .|  .....       |..| .    .  |   ..| . 
LSWHQRCSICWGTACGIQFLHQNHPCTPIIH-GDIKSANILLDQHFTPKICDFGLHRFGHPASHKEKQTYTCMMTSHVRGTTWYMPPEFIRDPQGQL-TK

KTDVYNFGFILLEILLGKPP
||||| ||  |||.| | ..
KTDVYSFGIVLLEVLTGCRA
Kinase IRAKd_a.AA LISK 499-635 23 1.6e-11 33.51 In-house 1-118 (296) Show / Hide 
Range on Protein: 499-635
Range on HMM: 1-118/296
Sequence Identity: 23% (34 aa)

LIGEGQHGKVFKGKLH-DGTVAAVKCLTL-----DSRQDMRQLKIHVELLVKIRHRHLVGYIGYSLDNVIDGARQCRKLYLVSEYIDNGTLRNHLS-SKF
 ||.|  |||.|| .  .|.| |.| ..      . .   . ..  |... ..||.. | ..| .           ..|..| |||. |.|.. |. ...
EIGKGFFGKVYKGTHRQTGQVMAIKMIHRQPNDPNDPEYQKFMLREVQMMKNLRHPNIVQFMGVCYH-------NDGQLHIVTEYINGGDLHQYLKDMDK

VTGLLGLMFCFSDLPVEAEGREVLSWSQRLAAAIGAGRGIQYLH
                      .|.|.||.  | .  .|  |||
-------------------HKIPLPWPQRVKIALDIACGMSYLH
Kinase IRAKd_a.AA Pkinase_Tyr 494-635 18 3.4e-11 38.53 Pfam 1-128 (270) Show / Hide 
Range on Protein: 494-635
Range on HMM: 1-128/270
Sequence Identity: 18% (28 aa)

FSLENLIGEGQHGKVFKGKLH-----DGTVAAVKCLTLDSRQD---MRQLKIHVELLVKI-RHRHLVGYIGYSLDNVIDGARQCRK--LYLVSEYIDNGT
 ..   .|||. |.|.||...     ...  |||.|  .. ..   .. .   .... .. .| ..| ..|  .       .| .   .|.| ||  .| 
ITFGKKLGEGAFGEVYKGTWKGDPDNTKIPVAVKMLKEGAMHEQNCREDFMREAKIMKQLGHHPNIVRLYGVCT-------DQGEPNQIYIVMEYMPHGD

LRNHLSSKFVTGLLGLMFCFSDLPVEAEGREVLSWSQRLAAAIGAGRGIQYLH
|...| ..                   |... |. .. |  ..   .| .||.
LLDYLRKHR------------------EDKQPLTMKDLLQMCWQIAKGMEYLE
Kinase IRAKd_a.AA TKL-Unique 496-588 31 7e-11 34.79 In-house 1-92 (290) Show / Hide 
Range on Protein: 496-588
Range on HMM: 1-92/290
Sequence Identity: 31% (31 aa)

LENLIGEGQHGKVFKGKLHDGTVAAVKCLTL--DSRQDMRQ-LKIHVELLVKIR-HRHLVGYIGYSLDNVIDGARQCRKLYLVSEYIDNGTLRNHLS
  |.||||  |.|.||| . |.  |.| . .  ||. .|.| .. .| .. |.. |  .| |.||. |       .  ....|.||.. |.|...|.
FWNKIGEGGYGQVYKGK-WRGYPVAIKQFHPNEDSSNEMMQEFENEVNWMKKLHYHPNIVHYMGYCMDHQV----YPPNMCIVMEYCPGGSLYDVLH
Kinase IRAKd_a.AA S_TKc 494-792 16 1.8e-10 -23.23 SMART 1-231 (231) Show / Hide 
Range on Protein: 494-792
Range on HMM: 1-231/231
Sequence Identity: 16% (55 aa)

FSLENLIGEGQHGKVFKGKLHD-GTVAAVKCLTLDSRQDMRQLKIHVELLVKIRHRHLVGYIGYSLDNVIDGARQCRKLYLVSEYIDN--GTLRNHLSSK
. . ..||.|  |||.|.. .. | . |.|..        ....  ...| | .| ..| ....  |          .||.| ||.|.  |.|. .. ..
YEILRKIGKGAFGKVYKCRHKKTGRIVAIKIIK-------EHIRREIQILKK-HHPNIVKLYDVFQD---------DHLYMVMEYCDGDLGDLFDYIKKR

FVTGLLGLMFCFSDLPVEAEGREVLSWSQRLAAAIGAGRGIQYLHTGVVPGIFNNDVNIT-------NVLMDQNCVAKFTDFGIGKHARTSCDFDAKVYV
   ||                | ...  .    .    ....|.|          . .|        |.|.|.  . | .|||. ..             
GRHGL----------------RFPFPE-HARFYMYQICCALEYCH----------SHGIIHRDLKPENILLDE--HIKICDFGLARQL------------

QKTPAH---------IDLDHHRRKLASD-KTDVYNFGFILLEILLGKPPTIEDSKSSVHPKEMLQTEHVPRYEVVDPAIIGNCVAESLTTVLEIAAKCLS
 .|            .          .  | |.. .| || | | |.||         ....|..                         ....  ||| 
-TTFCGTPWYMAPEVL--------GYGKCKCDWWSCGCILYEMLCGYPPFP-------QMQMMFKKIG-------------------SPEAKDFIRKCLQ

EEPSSRPSMEDVLW------NLQYA
 .|. ||.  ..|       . .. 
KDPEKRPTA-EALQDEWDIKCHPWF
Kinase IRAKd_a.AA ULK 494-554 19 6.4e-09 27.84 In-house 1-81 (324) Show / Hide 
Range on Protein: 494-554
Range on HMM: 1-81/324
Sequence Identity: 19% (16 aa)

FSLENLIGEGQHG-KVFKGK-LHD---GTVAAVKCLT---LDSRQDMR-------QLKIHVELLVKIR------HRHLVGYI
..| . .|.|. | ||.||.   .   . . |.|.     .   . ..       .||  .... |.       | | | ..
YCLNHCLGKGSFGVKVYKGRNKKTNTQNQYVACKMIDKKKMNKKKNEQEGQYMWQLLKNEIQIMKKLKELKHPNH-HIVKLY
Kinase IRAKd_a.AA IRAK 494-560 24 6.3e-08 24.35 In-house 1-75 (317) Show / Hide 
Range on Protein: 494-560
Range on HMM: 1-75/317
Sequence Identity: 24% (18 aa)

FSLENLIGEGQHGKVFKGKLHDGT-VAAVK----CLTLDSRQDMRQLKI---HVELLVKIRHRHLVGYIGYSLDN
|. .|.||||  | |..|...  | . |||       .   . ....      .... ..|| ..|   ||....
FHKDNRIGEGGFGCVYRGQWKNTTGIYAVKKLKEMADMSWNEHWQRFQQSYNELKVCCRCRHPNIVPLYGYCTER
Kinase IRAKd_a.AA Pkinase 494-590 18 7.2e-08 28.9 Pfam 1-100 (293) Show / Hide 
Range on Protein: 494-590
Range on HMM: 1-100/293
Sequence Identity: 18% (20 aa)

FSLENLIGEGQHGKVFKGKLHDGTV-AAVKCLTLDSRQD-MRQLKIH---VELLVKIRHRHLVGYIGYSLDNVIDGARQCRKLYLVSEYIDNG----TLR
. ..  ||.|  |.|.|.. ..     |||.. .... . ..| ...   .... ...| . | ....  |         ...|.| || ..|     | 
YHIGRKIGSGSFGCVYKCHHKGTGKIVAVKIIKKRHEKSWKDQTHRRLSEIQIMKRLNHPNIVRLYDWFED--------KDHIYMVMEYCEGGLYVMDLF

NHLS--SK
 ..|  ..
DYISTWRH
Kinase IRAKd_a.AA UTK 494-587 17 3e-06 17.56 In-house 1-101 (296) Show / Hide 
Range on Protein: 494-587
Range on HMM: 1-101/296
Sequence Identity: 17% (19 aa)

FSLENLIGEGQHGKVFKGKLHD----GTVAAVKCLTLDSRQDMRQLKI----------HVELLVKIR-HRHLVGYIGYSLDNVIDGARQCRKLYLVSEYI
  | ...|.|. | |.|... .    .....|.  ..... | .| .            . .. . . |..... .|. ..           ...|.|| 
VQLGRQLGQGAFGEVHKARFTQCSEHMYEMDVAVKVCQHHADAQQEPEPYPDFMEEARELQMMKQFHWHPNVLRLVGVCTQEEP--------WMIVTEYM

DNGTLRNHL
 || ||. |
ENGDLRSYL
Kinase IRAKd_a.AA RAF 494-556 31 5e-06 16.68 In-house 1-64 (275) Show / Hide 
Range on Protein: 494-556
Range on HMM: 1-64/275
Sequence Identity: 31% (21 aa)

FSLENLIGEGQHGKVFKGKLHDGTVAAVKCLTLDSRQD---MRQLKIHVELLVKIRHRHLVGYIGY
. .   || |  |.|..|. | |.| ||| |. .....   .   |  |  . |.|| ..|   ||
VQIGERIGQGRFGTVYRGHWH-GDV-AVKTLNMKYPTPEHQLQAFKNEVMMYKKTRHENIVLFMGY
Kinase IRAKd_a.AA TKL 696-789 19 6e-06 17.38 In-house 262-364 (364) Show / Hide 
Range on Protein: 696-789
Range on HMM: 262-364/364
Sequence Identity: 19% (22 aa)

RRKLASDKTDVYNFGFILLEILLGKPPTIEDSKSSVHPKE-MLQTEHVPR-------YEVV----DPAIIGNCV--------AESLTTVLEIAAKCLSEE
. . .| |.||| || .| ||| ...           | . .   .....       . |.     | |   .            .. . ... .| ...
KGFEYSEKCDVYSFGIVLWEILTRCR-----------PYYDYPYMPMIFQDPFEEMFMMVCDKGLRPPIPPIWQNHHKMCPCPDCPPSMKKLMQDCWDHD

PSSRPSMEDVLWNL
|..|||....|  |
PEKRPSFQEILKRL
Kinase IRAKd_a.AA Dicty4 769-791 28 2e-05 14.22 In-house 253-277 (277) Show / Hide 
Range on Protein: 769-791
Range on HMM: 253-277/277
Sequence Identity: 28% (7 aa)

AKCLSEEPSSRPSMEDVLWN--LQY
..|....|..|||.| ..    |  
QWCWDHDPQHRPSFEEIIQRRILEH
Kinase IRAKd_a.AA TK 766-789 20 0.00043 8.77 In-house 463-486 (486) Show / Hide 
Range on Protein: 766-789
Range on HMM: 463-486/486
Sequence Identity: 20% (5 aa)

EIAAKCLSEEPSSRPSMEDVLWNL
..  .| ...|. ||......  |
DLMQQCWHYDPEDRPTFSQLHEQL
Kinase IRAKd_a.AA UTK 763-789 25 0.000752 9.06 In-house 270-296 (296) Show / Hide 
Range on Protein: 763-789
Range on HMM: 270-296/296
Sequence Identity: 25% (7 aa)

TVLEIAAKCLSEEPSSRPSMEDVLWNL
.| ..  .|   .|. ||..||..  .
PVYRLMHRCWHYDPQERPDFEDLVQQM
Kinase IRAKd_a.AA RAF 763-789 25 0.000772 9.05 In-house 249-275 (275) Show / Hide 
Range on Protein: 763-789
Range on HMM: 249-275/275
Sequence Identity: 25% (7 aa)

TVLEIAAKCLSEEPSSRPSMEDVLWNL
.. |. . |.| .| .|||  ...  .
EMKELLMECWSYQPEERPSFQQIMKMI
Kinase IRAKd_a.AA Dicty4 494-558 27 0.001358 8.05 In-house 1-68 (277) Show / Hide 
Range on Protein: 494-558
Range on HMM: 1-68/277
Sequence Identity: 27% (19 aa)

FSLENLIGEGQHGKVFKGKLHDGTVAAVKCL----TLDSRQDMRQLKIHVELLVKIRHRHLVGYIGYSL
   |..||.|  |.|.||.   |.  ||| |    . ..   .  ..  |... |||| ...   |...
INIEQRIGKGSFGEVYKGTWR-GKEVAVKKLNNHNQNFDENMLNEFRKEVHIMCKIRHPNICLFMGACT
Kinase IRAKd_a.AA Dicty4 615-667 33 0.002057 7.44 In-house 106-160 (277) Show / Hide 
Range on Protein: 615-667
Range on HMM: 106-160/277
Sequence Identity: 33% (19 aa)

LSWSQRLA---AAIGAGRGIQYLHT-GVVPGIFNNDVNITNVLMDQNCVAKFTDFGI
|.|. ...    |. | ||...||.  .|  |  .|    | |.|.| ..| .|||.
LDWPLIKRAMRMAFDAARGMNWLHCCNPV--IIHRDLKSHNLLVDKNWRVKVCDFGL
Kinase IRAKd_a.AA RAF 701-723 39 0.019527 4.18 In-house 195-217 (275) Show / Hide 
Range on Protein: 701-723
Range on HMM: 195-217/275
Sequence Identity: 39% (9 aa)

SDKTDVYNFGFILLEILLGKPPT
| ..||| || .. |...|  |.
SFQSDVYAFGTVWYELMAGEWPY
Kinase IRAKd_a.AA TKL-Unique 770-789 35 0.024314 4.28 In-house 271-290 (290) Show / Hide 
Range on Protein: 770-789
Range on HMM: 271-290/290
Sequence Identity: 35% (7 aa)

KCLSEEPSSRPSMEDVLWNL
.|   .|| ||| ....  |
QCWHHDPSQRPSFDEIIHRL
Kinase IRAKd_a.AA Pkinase_Tyr 770-789 25 0.043057 7.71 Pfam 251-270 (270) Show / Hide 
Range on Protein: 770-789
Range on HMM: 251-270/270
Sequence Identity: 25% (5 aa)

KCLSEEPSSRPSMEDVLWNL
.|  ..|. ||....... |
QCWHYDPEDRPTFSEIHEQL
Kinase IRAKd_a.AA TKL-Unique 701-717 58 0.069094 2.66 In-house 206-222 (290) Show / Hide 
Range on Protein: 701-717
Range on HMM: 206-222/290
Sequence Identity: 58% (10 aa)

SDKTDVYNFGFILLEIL
| | ||| ||..| ||.
SEKSDVYSFGIVLWEIA
Kinase IRAKd_a.AA LISK 765-789 28 0.11059 1.01 In-house 272-296 (296) Show / Hide 
Range on Protein: 765-789
Range on HMM: 272-296/296
Sequence Identity: 28% (7 aa)

LEIAAKCLSEEPSSRPSMEDVLWNL
|... .| . .|..||| ....  |
LDLCFDCCKYDPKNRPSFKEIVQWL
DEAD IRAKd_a.AA DEAD 954-1112 26 4.9e-33 115.4 Pfam 1-172 (172) Show / Hide 
Range on Protein: 954-1112
Range on HMM: 1-172/172
Sequence Identity: 26% (47 aa)

DKFQRLAIEGFLKGSSVVVSAPTSSGKTLIAEAAAAATLAKCK----RLFYTTPLKALSNQKFRDFRKIFGDS--SVGLLTGDVSINRD----------A
 . |. ||. .|.| .|.|.||| |||||... .. ..|.| .    .  | .|...| .| ...|.|.|  .   |..|.|..|....          .
TPIQQQAIPAILEGRDVIVCAPTGSGKTLAFLIPILQHLLK-PWDGPQALYIAPTRELAQQIYEEFKKWFKYTGIRVCCLYGGDSMKEQRRKLRKGIGQC

PIVIMTTEIMRNKFYLSAGNEDVLQDLDVVVLDEIHYISDL-TRGTVWEETARVIYCP-KRIKLVCLSATIA-NPDEL
 ||..| .     .    |.   |... .||.||.| ..|   .| ...  | .  .| ...  ...|||.  |...|
HIVVGTPGRLLDHI--NRGH-LWLKNVKYVVIDEAHRMLDMKGFGHQMR-IA-IRHLPRPHRQTMMFSATMPRNVEDL
DEXDc IRAKd_a.AA DEXDc 949-1138 18 1.8e-30 108.45 SMART 1-219 (219) Show / Hide 
Range on Protein: 949-1138
Range on HMM: 1-219/219
Sequence Identity: 18% (42 aa)

YSFRLDKFQRLAIEGFLKGSSVVVSAPTSSGKTLIAEAAAAATLAK----------CKRLFYTTPLKALSNQKFRDFRKIFGD---------SSVGLLTG
   .. . |. ||.  |.| .|.. ||| |||||..  ...  | |           .|  ...|...| .| .. |.|.|..          .|....|
GF-KPRPYQQEAIPWILEGRDVIICAPTGSGKTLCFLIPILQHLKKGPPDDSKKGKGPRVLIICPTRELAEQWYEEFKKWFPHMGVYFVEWIKCVCYYGG

DVS---------INRDA-PIVIMTTEIMRNKFYLSAGNEDVLQDLDVVVLDEIHYISDL------TRGTVWEETARVIYCPKRIKLVCLSATIANPDELA
            . ... .||..|... .. .    .    | ..|.|..||.| ..|        .. ..|   . .  |. ......|||.  . . .
-SRTKEREQWRKLKSGCPHIVVTTPGRLLDHL-NDKF--LSL-NWDYVIIDEAHRMKDMQRGGDHGFRDQLE-ILKRL--PPNRQRILMSATPP-NIQNF

GWIAKV-----HGPTELITSYRRPVPLTWH
 |         ..| ... .  .. ... .
AWEFMNDPEYFPNPIFIMPGF-TNHWIEQF
HELICc IRAKd_a.AA HELICc 1282-1365 23 2.5e-12 48.22 SMART 1-86 (86) Show / Hide 
Range on Protein: 1282-1365
Range on HMM: 1-86/86
Sequence Identity: 23% (22 aa)

EAAVRPLYQG-------VAAHHAGCLPLWKSFIEELFQKGLVKVVFATETLAAGINMP-ARTTVLSSFSGKYQRRISANVVLQMAGRAGRRG
.   . | .        ||..|.|  .  .  |.| |..| .||...| ... ||..| ... .  ..      ...    .|..||||| |
DELAEYLKERFKWPGYKVARIHGGMPQEEREEIMERFRNGKIKVLVCTDVAERGIDIPNVDHVINYDM------PWNPAQYIQRIGRAGRAG
Helicase_C IRAKd_a.AA Helicase_C 1307-1365 28 6.1e-07 27.8 Pfam 23-76 (76) Show / Hide 
Range on Protein: 1307-1365
Range on HMM: 23-76/76
Sequence Identity: 28% (17 aa)

IEELFQKGLVKVVFATETLAAGINMPARTTVLSSFSGKYQRRISANVVLQMAGRAGRRG
|.| |..| .||...|  .. ||. |. ..|    .       .  . .|..||.|| |
IMERFRNGKCKVLVCTDVAGRGIDIPDVNHVINYDM-----PWNPEQYIQRIGRTGRAG
DSHCT IRAKd_a.AA DSHCT 1740-1915 22 4.3e-36 127.14 Pfam 1-189 (189) Show / Hide 
Range on Protein: 1740-1915
Range on HMM: 1-189/189
Sequence Identity: 22% (43 aa)

DRNTHKLLP--LGEIARAIRGSNELWLAIALRDEALLSLKPSELAAVAAALVTESPKSIPDNEYRTIYEPSA--VVKEWVEKMQSERLWLYGLQENHNVE
  . . ...   |..|..|.. .||||. .... ..  | | |.||.....|.|.... ..      |.||    ..| ...||  .  .. .|. ....
CDDDGVVTLTDKGRVACEIYSEDELWLTECIFNGFWNDLDPEECAALLSCFVFEERRDDEWQ-----YPPSLTPELAEAYNRMQDIWRRIAKVQRECQIN

FACDL-------DPQLAGFVEAWAAGVNWKELEIED-IMDEGDFARLLRRTIDLLSQIPHL---PHIDSELSKIAKEAARNMDRPPISEP---V
.  |        ...|.. |..|| |. ..|.  .   |.|||. |..||...|. ||..    .....|| . ..||   ..| .....   .
VDEDEDYVERFPNFGLMWVVYQWARGMSFQEICKMTPDMFEGDIVRWIRRLDELCRQIRNAARPIIGNPELEQKMEEAMELIRRDIVFAASLYL